Compounds > camptothecin

Page last updated: 2024-08-22

camptothecin and luotonin a

camptothecin has been researched along with luotonin a in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (35.71)	29.6817
2010's	7 (50.00)	24.3611
2020's	2 (14.29)	2.80

Authors

Authors	Studies
Cagir, A; Eisenhauer, BM; Gao, R; Hecht, SM; Jones, SH	2
Friedrich, TD; Guzzo, PR; Jason Herr, R; Nacro, K; Peace, D; Zha, CC	1
Almansour, AI; Altaf, M; Arumugam, N; Bianchini, G; Ghabbour, HA; Mahalingam, SM; Menéndez, JC; Sau, S; Suresh Kumar, R	1
He, C; He, M; Li, L; Liang, X; Luan, S; Lv, C; Song, X; Wu, Q; Yin, L; Yin, Z; Yuan, Z; Zhang, W; Zou, Y	1
Battisti, V; Deckardt, S; Haider, N; Haller, AV; Heffeter, P; Ibric, A; Langer, T; Lee, C; Marian, B; Prötsch, C; Schueffl, HH	1
Goon, S; Kundu, B; Mondal, MA; Sarkar, D; Talukdar, A	1
Cheng, K; Eisenhauer, BM; Gao, R; Hecht, SM; Rahier, NJ; Thomas, SJ	1
Liu, GS; Yao, ZJ; Zhou, HB	1
Corda, E; Girotti, S; González-Ruiz, V; Martín, MA; Mussardo, P; Olives, AI	1
Jahng, Y; Jeong, TC; Kim, DH; Lee, J; Lee, S	1
Bianchini, G; Fernández-Marcelo, T; González-Ruiz, V; Iniesta, P; Martín, MA; Menéndez, JC; Olives, AI; Pascua, I; Ramos, MT; Ribelles, P; Sridharan, V	1
Ayyanaar, S; Kesavan, MP; Kotla, NG; Kumar, GGV; Rajagopal, G; Rajesh, J; Sivaraman, G; Webster, TJ	1
Almansour, AI; Altaf, M; Arumugam, N; Bianchini, G; Dupadahalli, K; Kumar, RS; Menéndez, JC; Mohammad, F	1

Reviews

2 review(s) available for camptothecin and luotonin a

Article	Year
A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade. European journal of medicinal chemistry, 2019, Jun-01, Volume: 171 Topics: Coumarins; Diterpenes; DNA Topoisomerases; Fatty Acids; Flavonoids; Heterocyclic Compounds; Humans; Lignans; Organometallic Compounds; Polyphenols; Quinones; Topoisomerase Inhibitors	2019
Topoisomerase I inhibitors: Challenges, progress and the road ahead. European journal of medicinal chemistry, 2022, Jun-05, Volume: 236 Topics: Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; Irinotecan; Poisons; Topoisomerase I Inhibitors	2022

Other Studies

12 other study(ies) available for camptothecin and luotonin a

Article	Year
Synthesis and biochemical properties of E-ring modified luotonin A derivatives. Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9 Topics: Enzyme Inhibitors; Humans; Pyrroles; Quinones; Topoisomerase I Inhibitors	2004
Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives. Bioorganic & medicinal chemistry, 2007, Jun-15, Volume: 15, Issue:12 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Pyrroles; Quinones; Spectrometry, Mass, Electrospray Ionization; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2007
Design, synthesis and antiproliferative activity of decarbonyl luotonin analogues. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrroles; Quinones; Structure-Activity Relationship; Tumor Cells, Cultured	2017
A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies. Bioorganic & medicinal chemistry, 2020, 05-01, Volume: 28, Issue:9 Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Pyrroles; Quinones; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2020
Luotonin A. A naturally occurring human DNA topoisomerase I poison. Journal of the American Chemical Society, 2003, Nov-12, Volume: 125, Issue:45 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Camptothecin; DNA; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Pyrroles; Quinones; Topoisomerase I Inhibitors	2003
14-azacamptothecin: a potent water-soluble topoisomerase I poison. Journal of the American Chemical Society, 2005, Jan-26, Volume: 127, Issue:3 Topics: Camptothecin; Enzyme Inhibitors; Humans; Kinetics; Pyrroles; Quinones; Solubility; Topoisomerase I Inhibitors; Water	2005
Short and efficient total synthesis of luotonin A and 22-hydroxyacuminatine using a common cascade strategy. The Journal of organic chemistry, 2007, Aug-03, Volume: 72, Issue:16 Topics: Camptothecin; Chemistry, Organic; Fluorenes; Indolizines; Models, Chemical; Molecular Conformation; Pyrroles; Quinolines; Quinones	2007
Liquid chromatographic analysis of the anticancer alkaloid luotonin A and some new derivatives in human serum samples. Journal of separation science, 2010, Volume: 33, Issue:14 Topics: Alkaloids; Animals; Antineoplastic Agents; Camptothecin; Chromatography, Liquid; Humans; Molecular Structure; Pyrroles; Quinones; Reproducibility of Results	2010
Characterization of in vitro metabolites of luotonin A in human liver microsomes using electrospray/tandem mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:6 Topics: Biotransformation; Camptothecin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Metabolic Networks and Pathways; Microsomes, Liver; Molecular Weight; Protons; Pyrroles; Quinones; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2013
B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity. PloS one, 2014, Volume: 9, Issue:5 Topics: Amino Acids; Antineoplastic Agents; Camptothecin; Cerium; Chemistry, Pharmaceutical; Crystallization; DNA; DNA Topoisomerases, Type I; HeLa Cells; Humans; Hydrogen Bonding; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Nitrates; Protein Binding; Pyrroles; Quinones; Topoisomerase I Inhibitors	2014
A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy. Nanomedicine : nanotechnology, biology, and medicine, 2018, Volume: 14, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Drug Delivery Systems; Ferric Compounds; HeLa Cells; Humans; Magnetic Fields; MCF-7 Cells; Nanocomposites; Neoplasms; Pyrroles; Quinones; Theranostic Nanomedicine	2018
D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity. BioMed research international, 2019, Volume: 2019 Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Poly-ADP-Ribose Binding Proteins; Pyrroles; Quinones; Solubility; Structure-Activity Relationship; Topoisomerase Inhibitors	2019