Compounds > camptothecin
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camptothecin and homocamptothecin

camptothecin has been researched along with homocamptothecin in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (7.55)18.2507
2000's26 (49.06)29.6817
2010's20 (37.74)24.3611
2020's3 (5.66)2.80

Authors

AuthorsStudies
Bigg, DC; Camara, J; Demarquay, D; Harnett, J; Kasprzyk, PG; Lavergne, O; Lesueur-Ginot, L; Pla Rodas, F; Pommier, J; Pons, D; Prévost, G; Rolland, A; Schiano-Liberatore, AM; Ulibarri, G1
Bailly, C; Baroggi, N; Bigg, DC; Camara, J; Cazaux, JB; Coulomb, H; Demarquay, D; Huchet, M; Lanco, C; Lavergne, O; Le Breton, C; Manginot, E; Muller, N; Rolland, A1
Battistuzzi, G; Beretta, GL; Cabri, W; De Cesare, M; Giannini, G; Marastoni, E; Marzi, M; Pisano, C; Vesci, L; Zunino, F1
Huang, Q; Lu, W; Wang, L1
Bailly, C; Bigg, DC; Camara, J; Dassonneville, L; Demarquay, D; Kasprzyk, PG; Kiss, R; Lavergne, O; Lesueur-Ginot, L1
Agrawal, S; Chen, J; Chen, L; Le, LP; Oliver, P; Wang, H; Zeng, X; Zhang, R; Zhou, W1
Bailly, C; Bigg, DC; Coulomb, H; Dassonneville, L; Demarquay, D; Huchet, M; Lansiaux, A; Lavergne, O1
Bigg, DC; Bronckart, Y; Chaboteaux, C; da Costa, PM; Decaestecker, C; Gordover, L; Harper, L; Kiss, R; Lavergne, O; Lesueur-Ginot, L; Malonne, H; Philippart, P1
Pommier, Y; Takebayashi, Y; Urasaki, Y1
Bigg, DC; Demarquay, D; Kasprzyk, PG; Lavergne, O1
Bigg, DC; Chauvier, D; Chourpa, I; Manfait, M1
Bailly, C; Baldeyrou, B; Bigg, DC; Coulomb, H; Demarquay, D; Huchet, M; Laine, W; Lanco, C; Lavergne, O1
Wen, Z; Xiong, X; Zhu, Z1
Chauvier, D; Manfait, M; Morjani, H2
Li, P; Luo, L; Luo, Y; Peng, H; Tang, W1
Chen, HZ; Chen, Y; Ding, XQ; Kong, QY; Wang, AX1
Bailly, C1
Antony, S; Bates, SE; Kohlhagen, G; Medina-Pérez, WY; Nadjem, T; Pommier, Y; Robey, RW1
Yang, S; Zhang, WN1
Burke, TG; Curran, DP; Du, W; Jerina, DM; Kohlhagen, G; Laco, GS; Pommier, Y; Sayer, JM1
Chen, YT; Hong, GB; Jiang, RJ; Luo, JH; Xu, LF; Xu, LY; Zhou, JX1
Driver, RW; Yang, LX1
Chen, D; Chen, Y; Ding, XQ; Li, S; Wang, AX1
Agama, K; Anderson, BD; Antony, S; Bevins, R; Curran, DP; Pommier, Y; Tangirala, RS1
Althaus, M; Diolez, C; Manginot, E; Peters, R; Rolland, A; Veyrat, M1
Bailly, C; Bonte, JP; Dias, N; Foulon, C; Goossens, JF; Lansiaux, A; Mahieu, C; Principe, P; Vaccher, C1
Bates, SE; Guirouilh-Barbat, J; Liao, Z; Polgar, O; Pommier, Y; Robey, RW; To, KK1
Teicher, BA1
Che, X; Ji, H; Miao, Z; Shao, L; Sheng, C; Yao, J; You, L; Zhang, J; Zhang, M; Zhang, W1
Devaraj, S; Vadwai, V1
Che, X; Cheng, P; Feng, H; Guo, W; Liu, W; Luo, C; Miao, Z; Sheng, C; Wang, W; Xu, Y; Yao, J; Zhang, J; Zhang, W; Zhu, L1
Che, X; Cheng, P; Guo, W; Liu, W; Miao, Z; Sheng, C; Wang, W; Yao, J; Zhang, W; Zhu, L1
Che, X; Cheng, P; Dong, G; Feng, H; Guo, W; Liu, W; Luo, C; Miao, Z; Sheng, C; Wang, J; Wang, W; Xu, Y; Yao, J; You, L; Zhang, J; Zhang, W; Zhou, L; Zhu, L1
Deng, Q; Hu, GX; Huang, YQ; Yuan, F; Yuan, K; Zhang, Y1
Cheng, P; Dong, G; Guo, W; Liu, W; Miao, Z; Sheng, C; Wang, S; Wang, W; Yao, J; Zhang, W; Zhang, Y; Zhu, L; Zhuang, C1
Cheng, P; Dong, G; Guo, W; Liu, W; Miao, Z; Sheng, C; Yao, J; Zhang, W; Zhang, Y; Zhu, L; Zhuang, C1
Cheng, P; Dong, G; Guo, W; Lei, N; Liu, W; Miao, Z; Sheng, C; Wang, S; Yao, J; Zhang, W; Zhang, Y; Zhu, L; Zhuang, C1
He, ZG; Pu, XH; Qin, YM; Sun, J; Zhang, P; Zhang, X1
Nie, F; Ran, ZH; Tong, JL; Xiao, SD; Xu, XT; Zhang, CP; Zhu, MM1
Chen, Y; Huang, Q; Lu, W; Luo, Y; Tong, L; Yu, S1
Cheng, P; Dong, G; Guo, W; Lei, N; Liu, W; Miao, Z; Sheng, C; Yao, J; Zhang, W; Zhang, X; Zhu, L; Zhuang, C1
Deng, LH; Tang, CY; Tu, LX; Wu, CB; Xu, YH1
Dong, G; Guo, W; Guo, Z; Liu, W; Miao, Z; Sheng, C; Yao, J; Zhang, H; Zhang, W; Zhu, L; Zhuang, C1
Ji, TF; Li, DZ; Li, YR; Liu, RH; Pan, XD; Wang, CY; Wang, YM1
Cao, R; Chen, X; Geng, M; Li, P; Wang, L1
Duan, Y; Gong, T; Liu, P; Sun, X; Wang, Q; Zhang, Z1
Chen, Y; Lu, W; Ma, L; Wang, L; Xie, S1
Fan, R; Guo, X; Li, D; Li, Z; Liu, Y; Song, C; Tang, X; Xu, H; Zhang, Y; Zhang, Z1
Gao, S; Li, L; Liu, T; Ma, Q; Miller-Kleinhenz, J; Qin, Z; Tian, R; Wang, G; Zhang, F; Zhu, L1
Chen, Q; Hu, J; Liu, J; Luo, X; Meng, Z; Ni, Z; Sun, Y; Tang, L; Wang, X; Xiang, F; Zhang, M; Zhang, Z; Zhu, L1
He, H; Li, X; Liu, D; Liu, J; Ma, Z; Tang, X; Wang, Y; Xu, Y1
Cao, P; Cheng, Y; Cui, J; Fan, S; Li, Y; Shang, Y; Yin, X; Zhang, H1

Reviews

6 review(s) available for camptothecin and homocamptothecin

ArticleYear
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors

2013
Homocamptothecins: E-ring modified CPT analogues.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Animals; Antineoplastic Agents; Camptothecin; Enzyme Inhibitors; Humans; Xenograft Model Antitumor Assays

2000
Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs.
    Critical reviews in oncology/hematology, 2003, Volume: 45, Issue:1

    Topics: Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; Drug Design; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Leukemia; Topoisomerase I Inhibitors

2003
[Homocamptothecins--novel promising anticancer drugs as inhibitors of topoisomerase I].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; DNA Damage; Humans; Irinotecan; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

2004
Synthesis and pharmacology of new camptothecin drugs.
    Mini reviews in medicinal chemistry, 2005, Volume: 5, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Organosilicon Compounds

2005
Next generation topoisomerase I inhibitors: Rationale and biomarker strategies.
    Biochemical pharmacology, 2008, Mar-15, Volume: 75, Issue:6

    Topics: Animals; Antineoplastic Agents; Biomarkers; Camptothecin; Carbazoles; Humans; Indenes; Indoles; Isoquinolines; Naphthyridines; Topoisomerase I Inhibitors

2008

Trials

1 trial(s) available for camptothecin and homocamptothecin

ArticleYear
[Preliminary clinical comparison of HLF and ELF regimen in the treatment of advanced gastric carcinoma in middle-aged and elderly patients].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2000, Volume: 22, Issue:5

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Etoposide; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms

2000

Other Studies

46 other study(ies) available for camptothecin and homocamptothecin

ArticleYear
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
    Journal of medicinal chemistry, 1998, Dec-31, Volume: 41, Issue:27

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoxepins; Camptothecin; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Neoplasm Transplantation; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured

1998
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; HT29 Cells; Humans; Inhibitory Concentration 50; Stereoisomerism; Tumor Cells, Cultured

2000
E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation.
    Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2008
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
    Cancer research, 1999, Jun-15, Volume: 59, Issue:12

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Disease Models, Animal; DNA; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; HT29 Cells; Humans; K562 Cells; Lactones; Leukemia L1210; Leukemia, Experimental; Neoplasm Transplantation; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured

1999
MDM2 oncogene as a target for cancer therapy: An antisense approach.
    International journal of oncology, 1999, Volume: 15, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Choriocarcinoma; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Nuclear Proteins; Oligonucleotides, Antisense; Osteosarcoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Survival Rate; Tumor Cells, Cultured

1999
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.
    Biochemistry, 1999, Nov-23, Volume: 38, Issue:47

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Survival; DNA Topoisomerases, Type I; DNA, Superhelical; Drug Resistance, Neoplasm; Enzyme Inhibitors; Leukemia P388; Mice; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1999
Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4

    Topics: Antineoplastic Agents; Biopsy; Camptothecin; Cell Division; Colon; Colonic Neoplasms; Culture Techniques; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Etoposide; Humans; Irinotecan; Thymidine; Topoisomerase I Inhibitors; Topotecan; Tritium; Tumor Cells, Cultured

2000
Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations.
    Cancer research, 2000, Dec-01, Volume: 60, Issue:23

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cricetinae; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Enzyme Stability; Humans; Inhibitory Concentration 50; Leukemia P388; Male; Mice; Point Mutation; Prostatic Neoplasms; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2000
Kinetics of in vitro hydrolysis of homocamptothecins as measured by fluorescence.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Antineoplastic Agents; Camptothecin; DNA; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactones; Spectrometry, Fluorescence

2000
A novel B-ring modified homocamptothecin, 12-Cl-hCPT, showing antiproliferative and topoisomerase I inhibitory activities superior to SN-38.
    Anti-cancer drug design, 2001, Volume: 16, Issue:1

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Cell Survival; DNA, Neoplasm; DNA, Superhelical; Doxorubicin; Enzyme Inhibitors; HT29 Cells; Humans; Irinotecan; Plasmids; Topoisomerase I Inhibitors

2001
Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells.
    International journal of oncology, 2002, Volume: 20, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Survival; Ceramides; Colonic Neoplasms; Enzyme Inhibitors; Genes, p53; HT29 Cells; Humans; Lipids; Mutation; Sphingomyelin Phosphodiesterase; Sphingomyelins; trans-Golgi Network

2002
[Cell cycle block and apoptosis in rabbit lens epithelial cells induced by hydroxycamptothecine].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2002, Volume: 38, Issue:3

    Topics: Animals; Apoptosis; Camptothecin; Cell Cycle; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Fas Ligand Protein; fas Receptor; Female; Lens, Crystalline; Male; Membrane Glycoproteins; Rabbits; S Phase

2002
Homocamptothecin-daunorubicin association overcomes multidrug-resistance in breast cancer MCF7 cells.
    Breast cancer research and treatment, 2002, Volume: 73, Issue:2

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carcinoma; Colonic Neoplasms; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Leukemia, Myeloid; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Polymerase Chain Reaction; RNA, Neoplasm; Treatment Outcome; Tumor Cells, Cultured

2002
[Anticancer effect of hydroxycampothecin on oral squamous carcinoma cell line].
    Ai zheng = Aizheng = Chinese journal of cancer, 2002, Volume: 21, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Cell Cycle; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mouth Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Irinotecan; Neoplasm Proteins; Topoisomerase I Inhibitors

2004
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies.
    Bioorganic & medicinal chemistry, 2004, Oct-01, Volume: 12, Issue:19

    Topics: Binding Sites; Camptothecin; Deoxyguanosine; DNA; DNA Topoisomerases, Type I; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Nucleic Acid Conformation; Protein Binding; Static Electricity; Thermodynamics; Topoisomerase I Inhibitors

2004
[Efficacy of selective continuous transarterial infusion chemotherapy on advanced pancreatic cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Gemcitabine; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms; Remission Induction; Survival Rate

2004
[Antitumor effects of ring-closed and ring-opened hydroxycamptothecin on oral squamous carcinoma cell line Tca8113].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Humans; Lactones; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasm Transplantation

2005
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.
    Bioorganic & medicinal chemistry, 2006, Sep-15, Volume: 14, Issue:18

    Topics: Antineoplastic Agents; Biological Assay; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Topoisomerase Inhibitors

2006
Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates.
    The Journal of organic chemistry, 2006, Sep-29, Volume: 71, Issue:20

    Topics: Aldehydes; Antineoplastic Agents; Camptothecin; Heterocyclic Compounds, 4 or More Rings; Ketones; Pyridines

2006
Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.
    Electrophoresis, 2006, Volume: 27, Issue:23

    Topics: Antineoplastic Agents; beta-Cyclodextrins; Buffers; Camptothecin; Electrophoresis, Capillary; Enzyme Inhibitors; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfates; Temperature; Topoisomerase I Inhibitors

2006
Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.
    Molecular pharmacology, 2008, Volume: 73, Issue:2

    Topics: Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Glioblastoma; Humans; Topoisomerase I Inhibitors

2008
New homocamptothecins: synthesis, antitumor activity, and molecular modeling.
    Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3

    Topics: Antineoplastic Agents; Binding Sites; Camptothecin; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type I; Humans; Imaging, Three-Dimensional; Imines; Methylation; Models, Molecular; Molecular Structure; Protein Binding; Pyridines; Quantitative Structure-Activity Relationship; Solubility; Water

2008
Insilico analysis of homocamptothecin (hCPT) analogues for anti-tumour activity.
    International journal of bioinformatics research and applications, 2009, Volume: 5, Issue:6

    Topics: Antineoplastic Agents; Camptothecin; Molecular Structure; Monte Carlo Method

2009
Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:6

    Topics: Antineoplastic Agents; Benzylidene Compounds; Camptothecin; Cell Line, Tumor; DNA; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Topoisomerase I Inhibitors

2010
Trifluoromethyl-promoted homocamptothecins: synthesis and biological activity.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:7

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA; DNA Topoisomerases, Type I; Halogenation; Humans; Male; Mice; Topoisomerase I Inhibitors

2010
Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities.
    Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Drug Stability; Esters; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Molecular Structure; Pharmaceutical Solutions; Phosphates; Structure-Activity Relationship

2010
[Effect of hydroxycamptothecin (HCPT) on proliferation and apoptosis of rat hepatic stellate cells].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:3

    Topics: Animals; Apoptosis; Camptothecin; Cell Line; Cell Proliferation; Hepatic Stellate Cells; Rats

2010
Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Camptothecin; Cell Proliferation; Crystallography, X-Ray; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2011
Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities.
    Chemistry & biodiversity, 2011, Volume: 8, Issue:7

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Neoplasms; Topoisomerase I Inhibitors

2011
Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors.
    Archiv der Pharmazie, 2011, Volume: 344, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; HCT116 Cells; Humans; Neoplasms; Pyrimidines; Topoisomerase I Inhibitors

2011
[Pharmaceutical evaluation of hydroxycamptothecin nanosuspensions with the action of inhibiting P-gp].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calorimetry, Differential Scanning; Camptothecin; Cyclosporine; Drug Carriers; Drug Compounding; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Solubility; Suspensions; X-Ray Diffraction

2011
MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells.
    FEBS letters, 2011, Nov-16, Volume: 585, Issue:22

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; PPAR alpha; Reverse Transcriptase Polymerase Chain Reaction

2011
Synthesis and biological evaluation of new homocamptothecin analogs.
    European journal of medicinal chemistry, 2012, Volume: 54

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA Topoisomerases, Type I; Drug Stability; Humans; Structure-Activity Relationship; Topoisomerase I Inhibitors

2012
Synthesis and biological evaluation of 7-alkenyl homocamptothecins as potent topoisomerase I inhibitors.
    Chemistry & biodiversity, 2012, Volume: 9, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; DNA; DNA Cleavage; DNA Topoisomerases, Type I; Humans; Topoisomerase I Inhibitors; Topotecan

2012
[In vivo imaging in tumor-bearing animals and pharmacokinetics of PEGylated liposomes modified with RGD cyclopeptide].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:5

    Topics: Animals; Area Under Curve; Camptothecin; Diagnostic Imaging; Drug Delivery Systems; Female; Fluorescent Dyes; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Oligopeptides; Polyethylene Glycols; Random Allocation; Rats; Rats, Sprague-Dawley; Spectroscopy, Near-Infrared; Tissue Distribution

2012
Synthesis and biological assays of 9-(acylamino) homocamptothecins as DNA topoisomerase I inhibitors.
    Chemistry & biodiversity, 2013, Volume: 10, Issue:10

    Topics: Animals; Apoptosis; Binding Sites; Camptothecin; Catalytic Domain; Cell Line, Tumor; DNA Cleavage; DNA Topoisomerases, Type I; Enzyme Activation; HCT116 Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Docking Simulation; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous

2013
Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors.
    Journal of Asian natural products research, 2013, Volume: 15, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; Drug Screening Assays, Antitumor; Esters; Humans; Inhibitory Concentration 50; KB Cells; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors

2013
The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer.
    Diagnostic pathology, 2013, Dec-10, Volume: 8

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Cells, Cultured; Cisplatin; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Gastric Mucosa; Glutathione S-Transferase pi; Humans; In Vitro Techniques; Mitomycin; Stomach; Stomach Neoplasms

2013
Uptake mechanism and endosomal fate of drug-phospholipid lipid nanoparticles in subcutaneous and in situ hepatoma.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:6

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Diffusion; Endosomes; Liposomes; Male; Mice; Mice, Inbred C57BL; Nanocapsules; Organ Specificity; Phospholipids; Tissue Distribution

2014
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents.
    Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; HT29 Cells; Humans; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2015
A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Humans; Hydrogen-Ion Concentration; Mice, Inbred BALB C; Micelles; Neoplasms; Prodrugs; Proton Magnetic Resonance Spectroscopy; Rats; Solubility; Spectrometry, Fluorescence; Tissue Distribution

2017
Theranostic Hyaluronic Acid-Iron Micellar Nanoparticles for Magnetic-Field-Enhanced in vivo Cancer Chemotherapy.
    ChemMedChem, 2018, 01-08, Volume: 13, Issue:1

    Topics: Administration, Intravenous; Animals; Apoptosis; Camptothecin; Cell Line, Tumor; Drug Carriers; Female; Ferric Compounds; Humans; Hyaluronan Receptors; Hyaluronic Acid; Magnetic Fields; Magnetic Resonance Imaging; Mice; Mice, Nude; Micelles; Nanoparticles; Neoplasms; Positron-Emission Tomography; Theranostic Nanomedicine

2018
Decreasing Arl4c expression by inhibition of AKT signal in human lung adenocarcinoma cells.
    Life sciences, 2020, Apr-01, Volume: 246

    Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; ADP-Ribosylation Factors; Blotting, Western; Camptothecin; Cell Line, Tumor; Chromones; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Leupeptins; Lung Neoplasms; Morpholines; Proto-Oncogene Proteins c-akt; Signal Transduction; Smoking

2020
Hydroxycamptothecin (HCPT)-loaded PEGlated lipid-polymer hybrid nanoparticles for effective delivery of HCPT: QbD-based development and evaluation.
    Drug delivery and translational research, 2022, Volume: 12, Issue:1

    Topics: Animals; Camptothecin; Cell Line, Tumor; Drug Carriers; Mice; Nanoparticles; Particle Size; Polymers; Rats; Rats, Sprague-Dawley

2022
Fluorescent Imaging-Guided Chemo- and Photodynamic Therapy of Hepatocellular Carcinoma with HCPT@NMOFs-RGD Nanocomposites.
    International journal of nanomedicine, 2022, Volume: 17

    Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Mice; Nanocomposites; Oligopeptides; Photochemotherapy; Zebrafish

2022