Page last updated: 2024-08-22

camptothecin and genistein

camptothecin has been researched along with genistein in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (23.08)18.2507
2000's12 (46.15)29.6817
2010's7 (26.92)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Asao, Y; Matsuda, H; Miyagawa, K; Nakashima, S; Takayama, S; Xu, F; Yoshida, K; Yoshikawa, M1
Austin, CA; López-Lazaro, M; Willmore, E1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Hwang, TL; Khalil, AT; Kuo, YH; Liaw, CC; Lin, YS; Shen, YC1
Abd El-Razek, MH; Chiang, MY; Dai, CF; Hwang, TL; Kuo, YH; Lin, YC; Shen, YC1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1
Kondo, K; Oishi, M; Tsuneizumi, K; Watanabe, T1
Iwai, H; Kariya, K; Lee, E; Miura, M; Yoshinari, M1
Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R1
Crissman, HA; Sailer, BL; Steinkamp, JA; Valdez, JG1
Phan, TN; Tuteja, N1
Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS1
Davey, M; Davey, R; Locke, V1
Chan, PJ; Jacobson, JD; King, A; Patton, WC; Rowland, SC1
Li, GZ; Li, KS; Li, ZH; Yang, WM; Yu, WH; Zhou, XM1
Boutis, LL; Geromichalos, GD; Kalemi, TG; Kortsaris, AH; Kotsis, A; Lambropoulos, AF; Papazisis, KT; Zambouli, D1
Favoreel, HW; Geenen, K; Nauwynck, HJ1
Daidoji, T; Hu, M; Kulkarni, KH; Tang, L; Wang, JR; Wang, SW; Yin, T; Yokota, H1
Kawabe, Y; Mori, N; Murakami, T; Yokooji, T1
Fu, Q; Gao, JY; Gao, XP; Lei, YH; Li, JQ; Li, YM; Shao, C; Shi, CH; Shi, JG; Wang, H; Wang, JY; Wang, Y; Xu, P; Xue, W; Yuan, JL; Zhang, W; Zhang, YT1
Yokooji, T1
Li, FY; Liu, L; Liu, ZQ; Lu, L; Peng, XJ; Qi, XX; Shi, J; Wang, Y; Zhou, FY; Zhou, J1

Reviews

1 review(s) available for camptothecin and genistein

ArticleYear
[Role of ABC efflux transporters in the oral bioavailability and drug-induced intestinal toxicity].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2013, Volume: 133, Issue:7

    Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Camptothecin; Genistein; Intestines; Irinotecan; Methotrexate; Multidrug Resistance-Associated Proteins; Rats

2013

Other Studies

25 other study(ies) available for camptothecin and genistein

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
    Bioorganic & medicinal chemistry, 2007, Feb-01, Volume: 15, Issue:3

    Topics: Cell Differentiation; Cell Proliferation; Convolvulaceae; Enzyme Precursors; Fibrosarcoma; Flavonoids; Gelatinases; HL-60 Cells; Humans; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Plant Extracts; Rotenone; Tumor Cells, Cultured; U937 Cells

2007
Cells lacking DNA topoisomerase II beta are resistant to genistein.
    Journal of natural products, 2007, Volume: 70, Issue:5

    Topics: Animals; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Neoplasm; Genistein; Luteolin; Mice; Molecular Structure

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Frajunolides E-K, briarane diterpenes from Junceella fragilis.
    Journal of natural products, 2008, Volume: 71, Issue:9

    Topics: Animals; Anthozoa; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Diterpenes; Drug Screening Assays, Antitumor; Genistein; Humans; Molecular Structure; Neutrophils; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Elastase; Taiwan

2008
Asterolaurins A-F, xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae.
    Journal of natural products, 2009, Volume: 72, Issue:11

    Topics: Animals; Anthozoa; Antineoplastic Agents; Crystallography, X-Ray; Diterpenes; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Elastase; Taiwan

2009
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020
Induction of in vitro differentiation of mouse embryonal carcinoma (F9) cells by inhibitors of topoisomerases.
    Cancer research, 1991, Oct-01, Volume: 51, Issue:19

    Topics: Animals; Blotting, Western; Camptothecin; Cell Differentiation; Cell Line; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Genistein; In Vitro Techniques; Isoflavones; Laminin; Lewis X Antigen; Mice; Protein-Tyrosine Kinases; Teniposide; Teratoma; Tissue Plasminogen Activator; Topoisomerase I Inhibitors; Tretinoin

1991
Selective inhibition of dexamethasone-induced apoptosis in rat thymocytes by herbimycin A.
    Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1

    Topics: Animals; Apoptosis; Benzoquinones; Camptothecin; Catechols; Cells, Cultured; Dexamethasone; DNA; DNA Damage; Dose-Response Relationship, Drug; Etoposide; Genistein; Isoflavones; Kinetics; L-Lactate Dehydrogenase; Lactams, Macrocyclic; Nitriles; Nucleosomes; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Thymus Gland; Topoisomerase I Inhibitors; Tyrphostins

1994
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors

1997
Apoptosis induced with different cycle-perturbing agents produces differential changes in the fluorescence lifetime of DNA-bound ethidium bromide.
    Cytometry, 1998, Mar-01, Volume: 31, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Camptothecin; Cell Cycle; Chromatin; Cycloheximide; DNA, Neoplasm; Enzyme Inhibitors; Ethidium; Flow Cytometry; Fluorescence; Fluorescent Dyes; Gamma Rays; Genistein; HL-60 Cells; Humans; Protein Synthesis Inhibitors

1998
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
    Biochemical and biophysical research communications, 1998, Mar-27, Volume: 244, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum

1998
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
    Experimental neurology, 1999, Volume: 159, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates

1999
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
    Cytometry, 2001, Mar-01, Volume: 43, Issue:3

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carcinoma, Small Cell; Cell Cycle; Cell Survival; Chlorambucil; Cisplatin; Daunorubicin; Drug Resistance, Multiple; Epirubicin; Genistein; Humans; Lung Neoplasms; Paclitaxel; Tumor Cells, Cultured; Vinblastine; Vinorelbine

2001
Dual fluorescence analysis of DNA apoptosis in sperm.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:5

    Topics: Apoptosis; Benzimidazoles; Camptothecin; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Genistein; Humans; Male; Microscopy, Fluorescence; Necrosis; Propidium; Spermatozoa; Staining and Labeling

2003
[Comparison between two methods for staining DNA of apoptotic spermatozoa].
    Zhonghua nan ke xue = National journal of andrology, 2005, Volume: 11, Issue:2

    Topics: Apoptosis; Benzimidazoles; Camptothecin; Cell Survival; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Genistein; Humans; Male; Propidium; Sensitivity and Specificity; Spermatozoa; Staining and Labeling

2005
Synergistic effects of protein tyrosine kinase inhibitor genistein with camptothecins against three cell lines in vitro.
    Cancer letters, 2006, Feb-28, Volume: 233, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; CDC2 Protein Kinase; Cell Division; Cell Proliferation; Cells, Cultured; Drug Synergism; Female; Fibroblasts; G2 Phase; Genistein; HeLa Cells; Humans; In Vitro Techniques; Ovarian Neoplasms; Phosphorylation; Protein-Tyrosine Kinases

2006
Cell type-specific resistance of trigeminal ganglion neurons towards apoptotic stimuli.
    Veterinary microbiology, 2006, Mar-31, Volume: 113, Issue:3-4

    Topics: Animals; Apoptosis; Camptothecin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Herpesvirus 1, Suid; Neurons; Protein Kinases; Pseudorabies; Staurosporine; Swine; Trigeminal Ganglion; Virus Latency

2006
Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3

    Topics: Animals; Anticholesteremic Agents; Apigenin; Azetidines; Bile; Camptothecin; Enzyme Inhibitors; Ezetimibe; Flavonoids; Genistein; Glucuronic Acid; Glucuronosyltransferase; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Isoflavones; Liver; Male; Microsomes; Microsomes, Liver; Protein Isoforms; Rats; Rats, Gunn; Rats, Wistar; Recombinant Proteins; Testosterone; Up-Regulation

2009
Effect of genistein, a natural soy isoflavone, on the pharmacokinetics and intestinal toxicity of irinotecan hydrochloride in rats.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:2

    Topics: Alkaline Phosphatase; Animals; Biliary Tract; Body Weight; Camptothecin; Diarrhea; Drug Interactions; Genistein; Glucuronates; Glucuronides; Intestinal Mucosa; Intestines; Irinotecan; Kidney; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley

2013
Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; DNA Fragmentation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Genistein; Humans; I-kappa B Kinase; Mice; Mice, Nude; NF-kappa B; Protein Serine-Threonine Kinases; Signal Transduction; Topoisomerase I Inhibitors; Tumor Suppressor Proteins; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2013
Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Adult; Camptothecin; Carcinoma, Hepatocellular; Genistein; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Irinotecan; Liver Neoplasms; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Propofol; Tamoxifen; Zidovudine

2015