Page last updated: 2024-08-22

camptothecin and cysteine

camptothecin has been researched along with cysteine in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (68.75)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chung, IK; Kang, MR; Muller, MT1
Cao, S; Durrani, FA; Rustum, YM1
Azrak, RG; Cao, S; Durrani, FA; Frank, C; Li, ZR; Rustum, YM; Yin, MB1
Azrak, RG; Cao, S; Durrani, FA; Li, X; McLeod, HL; Pendyala, L; Rustum, YM; Shannon, WD; Smith, PF; Yu, J1
Cao, S; Durrani, FA; Fakih, M; Rustum, YM1
Azrak, RG; Bhattacharya, A; Cao, S; Durrani, FA; Frank, C; Hapke, G; Li, ZR; Rustum, YM; Tóth, K; Yin, MB1
Ewis, HE; Liu, P; Lu, CD; Tai, PC; Weber, IT1
Azrak, RG; Cao, S; Combs, GF; Durrani, FA; Fakih, M; Pendyala, L; Prey, J; Rustum, YM; Smith, PF1
Bjornsti, MA; Douat-Casassus, C; Montaudon, D; Palle, K; Pourquier, P; Quideau, S; Rivory, LP; Robert, J1
Doneanu, CE; Niture, SK; Pattabiraman, N; Srivenugopal, KS; Velu, CS1
Bhattacharya, A; Cao, S; Chintala, S; Durrani, FA; Rustum, YM; Slocum, HK; Tóth, K1
Cao, S; Chintala, S; Durrani, FA; Jensen, RL; Rustum, YM; Tóth, K; Vaughan, MM1
Chen, B; Zhang, X1
Azrak, RG; Bhattacharya, A; Cao, S; Durrani, FA; Rustum, YM; Toth, K1
Francesconi, S; Girard, PM; Graindorge, D; Rigolet, P; Sage, E; Scanlon, S; Smirnova, V1
Agatsuma, T1

Reviews

2 review(s) available for camptothecin and cysteine

ArticleYear
Selenium protects against toxicity induced by anticancer drugs and augments antitumor activity: a highly selective, new, and novel approach for the treatment of solid tumors.
    Clinical colorectal cancer, 2005, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cysteine; Drug Synergism; Humans; Irinotecan; Mice; Neoplasms; Organoselenium Compounds; Rats; Selenocysteine; Selenomethionine

2005
Development of New ADC Technology with Topoisomerase I Inhibitor.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2017, Volume: 137, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Camptothecin; Cysteine; Drug Delivery Systems; Drug Discovery; Humans; Immunoconjugates; Molecular Targeted Therapy; Rats; Receptor, ErbB-2; Topoisomerase I Inhibitors; Trastuzumab

2017

Other Studies

14 other study(ies) available for camptothecin and cysteine

ArticleYear
Telomeric DNA damage by topoisomerase I. A possible mechanism for cell killing by camptothecin.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Apoptosis; Binding Sites; Biological Assay; Camptothecin; Cysteine; DNA; DNA Damage; DNA Topoisomerases, Type I; Enzyme Inhibitors; Genome; HeLa Cells; Humans; Models, Biological; Plasmids; Potassium; Scleroderma, Localized; Sodium Dodecyl Sulfate; Telomere

2004
Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Apr-01, Volume: 10, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Colonic Neoplasms; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Organoselenium Compounds; Radiation-Sensitizing Agents; Selenium; Selenocysteine; Selenomethionine; Time Factors

2004
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
    Molecular pharmacology, 2004, Volume: 66, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carbon-Sulfur Lyases; Caspase 3; Caspases; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Survival; Checkpoint Kinase 1; Checkpoint Kinase 2; Cysteine; DNA Fragmentation; Drug Interactions; Enzyme Activation; Gene Expression; Humans; Irinotecan; Minichromosome Maintenance Complex Component 2; Nuclear Proteins; Organoselenium Compounds; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae Proteins; Selenocysteine

2004
Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoma, Squamous Cell; Cysteine; Female; Head and Neck Neoplasms; Humans; Irinotecan; Mice; Mice, Nude; Organoselenium Compounds; Pharmacogenetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Selenocysteine; Transplantation, Heterologous; Tumor Cells, Cultured

2005
Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1alpha expression, resulting in reduced angiog
    Oncogene, 2006, Apr-20, Volume: 25, Issue:17

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Cyclooxygenase 2; Cysteine; Down-Regulation; Female; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Irinotecan; Mice; Mice, Nude; Neovascularization, Pathologic; Nitric Oxide Synthase Type II; Organoselenium Compounds; Selenocysteine; Transplantation, Heterologous

2006
Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11.
    Journal of molecular biology, 2007, Mar-16, Volume: 367, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Bacillaceae; Binding Sites; Camptothecin; Carboxylesterase; Crystallization; Crystallography; Cysteine; Iodine; Irinotecan; Models, Molecular; Prodrugs; Protein Conformation

2007
Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent.
    Biochemical pharmacology, 2007, May-01, Volume: 73, Issue:9

    Topics: Administration, Oral; Animals; Bone Marrow; Camptothecin; Cysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Irinotecan; Kidney; Kinetics; Liver; Mice; Mice, Nude; Neoplasms; Organoselenium Compounds; Plasma; Selenium; Selenocysteine

2007
Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505.
    The Journal of biological chemistry, 2007, May-11, Volume: 282, Issue:19

    Topics: Arsenicals; Camptothecin; Cysteine; DNA Cleavage; DNA Topoisomerases, Type I; Enzyme Inhibitors; Ethylmaleimide; Humans; Mutagenesis, Site-Directed; Protein Conformation; Sulfhydryl Compounds; Topoisomerase I Inhibitors

2007
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.
    Biochemistry, 2007, Jul-03, Volume: 46, Issue:26

    Topics: Acetylcysteine; Amino Acid Sequence; Binding Sites; Buthionine Sulfoximine; Camptothecin; Cell Line, Tumor; Cross-Linking Reagents; Cysteine; Diamide; DNA Damage; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutaral; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Models, Molecular; Oxidative Stress; Phosphorylation; Recombinant Proteins; Tandem Mass Spectrometry; tert-Butylhydroperoxide; Tumor Suppressor Protein p53

2007
Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Squamous Cell; Cell Differentiation; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cysteine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forkhead Transcription Factors; Head and Neck Neoplasms; Humans; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Organoselenium Compounds; Selenocysteine; Tirapazamine; Triazines; Xenograft Model Antitumor Assays

2008
Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:5

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Cysteine; Drug Delivery Systems; Female; Gene Knockdown Techniques; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Irinotecan; Mice; Mice, Nude; Organoselenium Compounds; Reactive Oxygen Species; RNA, Small Interfering; Selenocysteine; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2010
Recombinant high density lipoprotein reconstituted with apolipoprotein AI cysteine mutants as delivery vehicles for 10-hydroxycamptothecin.
    Cancer letters, 2010, Dec-01, Volume: 298, Issue:1

    Topics: Animals; Apolipoprotein A-I; Camptothecin; Cysteine; Drug Carriers; Female; HCT116 Cells; Humans; Lipoproteins, HDL; Mice; Mice, Inbred BALB C; Nanoparticles; Pharmaceutical Vehicles; Recombinant Fusion Proteins; Tissue Distribution

2010
Augmented therapeutic efficacy of irinotecan is associated with enhanced drug accumulation.
    Cancer letters, 2011, Dec-08, Volume: 311, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Chromatography, High Pressure Liquid; Cysteine; Drug Synergism; Female; Humans; Immunohistochemistry; Irinotecan; Mice; Mice, Nude; Neoplasms, Experimental; Organoselenium Compounds; Selenocysteine; Xenograft Model Antitumor Assays

2011
Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Camptothecin; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cysteine; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Homologous Recombination; Humans; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species

2013