camptothecin has been researched along with cyclosporine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 14 (50.00) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR | 1 |
| Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR | 1 |
| Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Arefolov, A; Clardy, J; Clarke, AS; Ishihara, K; Marks, KM; Park, ES; Pelish, HE; Ring, JE; Russo, K | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Gupta, E; Ratain, MJ; Safa, AR; Wang, X | 1 |
| Fang, M; Huang, QQ; Xue, SB; Zhang, HQ | 1 |
| de Bruijn, P; de Jonge, MJ; Kurihara, M; Nishiyama, M; Sparreboom, A; Takano, H; Verweij, J; Yamamoto, W | 1 |
| Braun, MS; Button, CJ; Cheeseman, SL; Chester, JD; Davis, T; Hall, GD; Joel, SP; Perry, J; Seymour, MT | 1 |
| Arimori, K; Hidaka, M; Iwakiri, T; Kikuchi, M; Kuroki, N; Nakano, M; Okumura, M; Ono, H; Takamura, N; Yamsaki, K | 1 |
| Fang, X; Sha, X | 1 |
| Innocenti, F; Mani, S; Prado, M; Ramírez, J; Ratain, MJ; Schilsky, RL; Undevia, SD; Vogelzang, NJ | 1 |
| Fang, XL; Sha, XY; Wu, YJ | 1 |
| Beauchemin, M; Bertrand, R; Paquet, C; Sané, AT | 1 |
| Agamah, E; Desai, AA; Kindler, HL; Mani, S; Ratain, MJ; Taber, D; Vokes, EE; Wade-Oliver, K | 1 |
| Anthoney, DA; Jagdev, S; Seymour, MT; Vasudev, NS | 1 |
| Sinko, PJ; Su, Y | 1 |
| Cai, M; Mo, C; Qian, Y; Shi, B; Wang, Y; Zhou, W | 1 |
| Barker, JN; Gupta, NK; Noy, A; Young, JW | 1 |
| He, ZG; Pu, XH; Qin, YM; Sun, J; Zhang, P; Zhang, X | 1 |
| Hu, M; Huang, J; Lv, C; Zhong, G | 1 |
| Blake, D; Bridgewater, J; Brown, S; Chau, I; Gollins, S; Gwyther, S; Hill, M; Lowe, C; Maisey, N; Marshall, H; Maughan, T; Middleton, G; Myint, S; Napp, V; Oliver, A; Richman, S; Seymour, M; Slater, S; Wadsley, J; Wagstaff, J | 1 |
1 review(s) available for camptothecin and cyclosporine
| Article | Year |
|---|---|
Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it?
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Camptothecin; Cyclosporine; Drug Delivery Systems; Humans; Membrane Transport Proteins | 2006 |
4 trial(s) available for camptothecin and cyclosporine
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of intravenous irinotecan plus oral ciclosporin in patients with fuorouracil-refractory metastatic colon cancer.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Cyclosporine; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoplasm Staging; Treatment Outcome | 2003 |
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Endpoint Determination; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Half-Life; Humans; Hypnotics and Sedatives; Immunosuppressive Agents; Irinotecan; Lymphoma; Male; Middle Aged; Neoplasms; Phenobarbital | 2004 |
Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Cyclosporine; Drug Interactions; Female; Humans; Immunosuppressive Agents; Irinotecan; Male; Middle Aged | 2005 |
A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO).
Topics: Administration, Oral; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Camptothecin; Colorectal Neoplasms; Cyclosporine; Diarrhea; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Odds Ratio; Time Factors; Treatment Outcome; United Kingdom | 2013 |
23 other study(ies) available for camptothecin and cyclosporine
| Article | Year |
|---|---|
Highly predictive and interpretable models for PAMPA permeability.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine | 2017 |
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States | 2020 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.
Topics: Aflatoxin B1; Aflatoxins; Antineoplastic Agents; Aspergillus; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; DNA Damage; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Molecular Structure | 2011 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Camptothecin; Cyclosporine; Female; Irinotecan; Rats; Rats, Wistar | 1996 |
Cyclosporine inhibited calcium-mediated apoptosis of HL-60 cells.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Calcimycin; Calcium; Camptothecin; Cyclosporine; Harringtonines; HL-60 Cells; Humans; Immunosuppressive Agents; Thapsigargin | 1997 |
Active transepithelial transport of irinotecan (CPT-11) and its metabolites by human intestinal Caco-2 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Biological Transport; Biotransformation; Caco-2 Cells; Camptothecin; Cell Survival; Chromatography, High Pressure Liquid; Cyclosporine; Humans; Intestinal Mucosa; Irinotecan; Quinolines; RNA, Messenger; Verapamil | 2001 |
Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bile; Camptothecin; Chromatography, High Pressure Liquid; Cyclosporine; Digestive System; Epithelium; Immunosuppressive Agents; In Vitro Techniques; Irinotecan; Liver; LLC-PK1 Cells; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Rats; Rats, Wistar; Swine; Tissue Distribution | 2003 |
Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs.
Topics: Animals; Antineoplastic Agents; Biological Transport; Caco-2 Cells; Camptothecin; Cyclosporine; Duodenum; Humans; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Verapamil | 2004 |
[The in vitro kinetics of uptake, transport and efflux of 9-nitrocamptothecin in Caco-2 cell model].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Camptothecin; Cyclosporine; Humans; Hydrogen-Ion Concentration; Temperature; Verapamil | 2004 |
Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.
Topics: Apoptosis; bcl-X Protein; Bongkrekic Acid; Camptothecin; Caspases; Cathepsin B; Cell Line, Tumor; Cyclosporine; DNA Damage; Humans; Lysosomes; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Time Factors; U937 Cells | 2005 |
Intravenous irinotecan plus oral ciclosporin.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cyclosporine; Female; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged | 2005 |
Additive immunosuppressive effect of hydroxycamptothecin and cyclosporine on rejection of heart transplantation in rats.
Topics: Animals; Camptothecin; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Rats, Wistar; Survival Analysis; Time Factors; Transplantation, Homologous | 2007 |
Fourth complete remission with immunosuppression withdrawal and irinotecan after both autologous and allogeneic transplants for diffuse large B cell lymphoma.
Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Combined Modality Therapy; Cyclosporine; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Irinotecan; Lymphoma, Large B-Cell, Diffuse; Remission Induction; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome | 2009 |
[Pharmaceutical evaluation of hydroxycamptothecin nanosuspensions with the action of inhibiting P-gp].
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calorimetry, Differential Scanning; Camptothecin; Cyclosporine; Drug Carriers; Drug Compounding; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Solubility; Suspensions; X-Ray Diffraction | 2011 |
The mitochondria-mediate apoptosis of Lepidopteran cells induced by azadirachtin.
Topics: Animals; Apoptosis; Camptothecin; Caspases; Cell Respiration; Cell Survival; Cyclosporine; Cytochromes c; DNA Fragmentation; Enzyme Activation; Insecticides; Lepidoptera; Limonins; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Reactive Oxygen Species; Sf9 Cells | 2013 |