camptothecin has been researched along with chimmitecan in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Y; Chen, Y; Ding, J; Gao, H; Huang, M; Jiang, H; Lin, L; Lu, W; Miao, Z; Shen, H; Zhang, J; Zhang, X; Zhu, H | 1 |
| Cai, YJ; Ding, J; Huang, M; Lu, W; Miao, ZH; Zhu, H | 1 |
| Du, F; Hu, Z; Huang, Y; Li, C; Niu, W; Sun, Y; Xu, F | 1 |
| Du, FF; Hu, ZY; Li, C; Li, XX; Niu, W; Sun, Y; Wang, FQ; Xu, F; Yang, JL | 1 |
| Bo, Y; Chen, X; Gong, J; Li, J; Shen, L; Yang, F; Zhan, Y; Zhang, Q; Zhang, Y; Zhong, D; Zhou, J | 1 |
1 trial(s) available for camptothecin and chimmitecan
| Article | Year |
|---|---|
A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Linear Models; Neoplasms; Reproducibility of Results; Tandem Mass Spectrometry | 2021 |
4 other study(ies) available for camptothecin and chimmitecan
| Article | Year |
|---|---|
Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.
Topics: Animals; Apoptosis; Camptothecin; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Female; HL-60 Cells; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Models, Molecular; Topotecan | 2007 |
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
Topics: Apoptosis; Camptothecin; Cell Cycle; Cell Survival; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Breaks, Double-Stranded; DNA Repair; Enzyme Activation; G2 Phase; HCT116 Cells; HT29 Cells; Humans; Kinetics; Mitosis; Protein Kinases; Protein Serine-Threonine Kinases; Rad51 Recombinase; Recombination, Genetic | 2008 |
Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Dogs; Enzyme Inhibitors; Male; Mice; Mice, Nude; Prodrugs; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carboxylesterase; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Injections, Intravenous; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Microsomes, Liver; Prodrugs; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution; Xenograft Model Antitumor Assays | 2013 |