camptothecin has been researched along with benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 15 (51.72) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Alcolea, V; Encío, I; Palop, JA; Plano, D; Sanmartín, C; Sharma, AK | 1 |
| Pommier, Y; Shimizu, T | 1 |
| Cao, CX; Pommier, Y; Shao, RG | 1 |
| Bertrand, R; Sané, AT | 2 |
| Fladmark, KE; Gjertsen, BT; Jensen, PH; Vintermyr, OK | 1 |
| Abdel-Meguid, SS; Adams, JL; Badger, AM; Chan, G; Chan, W; Concha, NO; Debouck, C; DeWolf, WE; Francis, TA; Gowen, M; Haltiwanger, RC; Head, MS; Janson, CA; Johanson, K; Keller, PM; Kikly, K; Lark, MW; Lee, D; Levy, MA; Liang, PH; Long, SA; McDevitt, PJ; Nadeau, DP; Nuttall, ME; Richardson, S; Ryan, MD; Sung, CM; Suva, LJ; Tomaszek, T; Vaidya, KS; Winkler, JD | 1 |
| Amstad, P; Bedner, E; Darzynkiewicz, Z; Smolewski, P | 1 |
| Ault, JG; Khodjakov, A; Sánchez-Alcázar, JA; Schneider, E | 1 |
| Cao, CX; Dimanche-Boitrel, MT; Nieves-Neira, W; Pommier, Y; Shao, RG; Solary, E | 1 |
| Mashima, T; Tsuruo, T; Udagawa, S | 1 |
| Darzynkiewicz, Z; Grabarek, J; Phelps, DJ; Smolewski, P | 1 |
| Darzynkiewicz, Z; Dragan, M; Grabarek, J; Johnson, GL; Lee, BW | 1 |
| King, MA; Radicchi-Mastroianni, MA | 2 |
| Gasparri, F; Muzio, M | 1 |
| Baek, M; Bang, YJ; Cho, HN; Ha, JH; Jeoung, DI; Kim, HY; Lee, DY; Lee, HS; Lee, S; Lee, YS | 1 |
| Cotter, TG; Curtin, J; Hynes, J; O'Riordan, TC; Papkovsky, DB | 1 |
| Brea-Calvo, G; Cordero, M; Fernández-Ayala, DJ; Navas, P; Rodríguez-Hernández, A; Sánchez-Alcázar, JA | 1 |
| Avalos-Díaz, E; Bollain-y-Goytia, JJ; Herrera-Esparza, R; López-Robles, E; Meza-Lamas, E; Ramírez-Sandoval, R; Sánchez-Rodríguez, SH | 1 |
| Bell, CW; Jiang, W; Pisetsky, DS; Reich, CF | 1 |
| Brandi, A; Cardona, F; Cordero, FM; Grelli, S; Macchi, B; Mastino, A; Minutolo, A | 1 |
| Auladell, C; Beas-Zarate, C; Camins, A; Folch, J; Junyent, F; Pallàs, M; Pizarro, JG; Verdaguer, E | 1 |
| Avalos-Diaz, E; Bollain-y-Goytia, JJ; Daneri-Navarro, A; Herrera-Esparza, R; Ramírez-Sandoval, R; Vazquez-del-Mercado, M | 1 |
| Du, J; Qian, C; Tang, W; Yuan, Z; Zhang, Y | 1 |
| Becker, S; Groseth, A; Jackson, D; Kaufmann, A; Meyer, B; Strecker, T; Wolff, S | 1 |
| Grasso, F; Han, SH; Han, YS; Kim, IS; Kim, J; Tran, AHV | 1 |
| Chen, BH; Chen, JY; Chiu, CC; Chiu, YH; Hsu, HW; Hsu, SH; Huang, KC; Huang, WP; Liu, W; Wu, CY | 1 |
| Shu, B; Veeran, S; Zhang, J; Zhong, G | 1 |
29 other study(ies) available for camptothecin and benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
| Article | Year |
|---|---|
Chalcogen containing heterocyclic scaffolds: New hybrids with antitumoral activity.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Chalcogens; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Structure-Activity Relationship | 2016 |
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Nucleus; Cell-Free System; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Gene Deletion; Genes, p53; HL-60 Cells; Humans; Isocoumarins; Lamin Type B; Lamins; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Prodrugs; Serine Endopeptidases; Serine Proteinase Inhibitors; Tumor Suppressor Protein p53 | 1997 |
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Up-Regulation | 1997 |
Distinct steps in DNA fragmentation pathway during camptothecin-induced apoptosis involved caspase-, benzyloxycarbonyl- and N-tosyl-L-phenylalanylchloromethyl ketone-sensitive activities.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Division; Cell Survival; Cell-Free System; Cysteine Endopeptidases; DNA Fragmentation; Humans; Protein Synthesis Inhibitors; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 1998 |
Caspase I-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 1; Cell Death; HL-60 Cells; Humans; Okadaic Acid; Phenotype; Plasminogen Activator Inhibitor 2; Protease Inhibitors | 1999 |
Caspase inhibition in camptothecin-treated U-937 cells is coupled with a shift from apoptosis to transient G1 arrest followed by necrotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase Inhibitors; Cell Cycle Proteins; DNA Damage; DNA Fragmentation; DNA Repair; DNA Replication; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Necrosis; Neoplasm Proteins; Topoisomerase I Inhibitors; U937 Cells | 1999 |
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Binding Sites; Camptothecin; Caspase 3; Caspase 7; Caspase Inhibitors; Chondrocytes; Collagen; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Isatin; Mice; Models, Molecular; Molecular Structure; Neutrophils; Osteoarthritis; Promoter Regions, Genetic; Recombinant Proteins; Sulfonamides | 2000 |
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase Inhibitors; Caspases; Cycloheximide; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Inhibitors; Fluorescent Dyes; HL-60 Cells; Humans; In Situ Nick-End Labeling; Protein Synthesis Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Camptothecin; Caspases; Cytochrome c Group; Electron Transport Complex IV; Enzyme Inhibitors; Humans; Jurkat Cells; Membrane Potentials; Mitochondria; Proteins; Time Factors | 2000 |
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carrier Proteins; Colonic Neoplasms; Cycloheximide; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Genes, p53; HT29 Cells; Humans; Membrane Glycoproteins; Mutation | 2001 |
Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis.
Topics: Activating Transcription Factor 3; Active Transport, Cell Nucleus; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Camptothecin; Caspase Inhibitors; Caspases; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibrosarcoma; Gene Expression Regulation; HeLa Cells; Humans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Topoisomerase I Inhibitors; Transcription Factors; Transfection; Tumor Cells, Cultured | 2001 |
Stathmo-apoptosis: arresting apoptosis by fluorochrome-labeled inhibitor of caspases.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase Inhibitors; Caspases; Cell Cycle; Cysteine Proteinase Inhibitors; Flow Cytometry; Fluorescent Dyes; Humans; Propidium; Tumor Cells, Cultured | 2001 |
Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor.
Topics: Affinity Labels; Amino Acid Chloromethyl Ketones; Apoptosis; Binding Sites; Camptothecin; Enzyme Activation; Flow Cytometry; Fluorescein; HL-60 Cells; Humans; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Effects of caspase inhibition on camptothecin-induced apoptosis of HL-60 cells.
Topics: Amino Acid Chloromethyl Ketones; Annexin A5; Camptothecin; Caspase Inhibitors; Cell Membrane; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Phosphatidylserines | 2002 |
Monitoring of apoptosis of HL60 cells by Fourier-transform infrared spectroscopy.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase Inhibitors; Caspases; Cell Division; Cell Size; Cysteine Proteinase Inhibitors; DNA; HL-60 Cells; Humans; Spectroscopy, Fourier Transform Infrared | 2003 |
Antimycin A-induced apoptosis of HL-60 cells.
Topics: Amino Acid Chloromethyl Ketones; Annexin A5; Anti-Bacterial Agents; Antimycin A; Apoptosis; Camptothecin; Caspase Inhibitors; Cell Division; Cell Membrane; Cysteine Proteinase Inhibitors; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; HL-60 Cells; Humans; Phosphatidylserines; Time Factors | 2002 |
MAPK signaling is involved in camptothecin-induced cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2002 |
Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction.
Topics: Amino Acid Chloromethyl Ketones; Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspase Inhibitors; Caspases; Cell Respiration; Cysteine Proteinase Inhibitors; Electron Transport; Fluorescent Dyes; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Mitochondrial Membranes; Oxygen; Ultraviolet Rays | 2005 |
Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; Enzyme Activation; Humans; Oligopeptides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases | 2006 |
Camptothecin induces the transit of FasL trimers to the cell surface in apoptotic HEp-2 cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Deoxyribonucleases; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Humans; In Situ Nick-End Labeling; Poly-ADP-Ribose Binding Proteins; Protein Structure, Quaternary; Protein Transport; Subcellular Fractions; Transcription, Genetic | 2006 |
The extracellular release of HMGB1 during apoptotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; HMGB1 Protein; Humans; Hydroxamic Acids; Protein Synthesis Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha | 2006 |
The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glucan 1,4-alpha-Glucosidase; Humans; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship | 2010 |
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Calpain; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Dipeptides; DNA Damage; DNA-Binding Proteins; Humans; Morpholines; Neuroblastoma; Protein Serine-Threonine Kinases; Purines; Pyrones; Roscovitine; Tumor Suppressor Proteins | 2011 |
Caspase 3 blocking avoids the expression of autoantigens triggered by apoptosis in neonatal Balb/c mice skin.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Autoantigens; Autoimmune Diseases; Biopsy; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; Drug Evaluation, Preclinical; Hydrogen Peroxide; In Situ Nick-End Labeling; Mercuric Chloride; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Skin | 2011 |
Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspase 8; Caspase 9; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Microscopy, Electron, Transmission; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tenon Capsule | 2012 |
The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Arenaviruses, New World; Camptothecin; Caspases; Cell Line, Tumor; Chlorocebus aethiops; Gene Expression Regulation; Hepatocytes; Host-Pathogen Interactions; Humans; Junin virus; Macrophages; Poly(ADP-ribose) Polymerases; Primary Cell Culture; Signal Transduction; Tubulin; Ultraviolet Rays; Vero Cells; Virus Replication | 2016 |
MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Camptothecin; Caspase 8; Cell Line; Cells, Cultured; DNA Glycosylases; Fluorescent Antibody Technique; Immunoprecipitation; Mice; Necrosis; Protein Binding; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; TNF Receptor-Associated Death Domain Protein; Tumor Necrosis Factor-alpha | 2017 |
Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Cell Line, Tumor; Cell Movement; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms | 2018 |
Pro-Apoptotic Function Analysis of the Reaper Homologue IBM1 in
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Camptothecin; Caspase Inhibitors; Gene Expression Regulation, Developmental; Insect Proteins; Jumonji Domain-Containing Histone Demethylases; Limonins; Mitochondria; Phylogeny; Real-Time Polymerase Chain Reaction; Sf9 Cells; Spodoptera; Ultraviolet Rays; Up-Regulation | 2020 |