camptothecin has been researched along with aphidicolin in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.14) | 18.7374 |
| 1990's | 35 (62.50) | 18.2507 |
| 2000's | 13 (23.21) | 29.6817 |
| 2010's | 3 (5.36) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Cotter, TG | 1 |
| D'Arpa, P; Liu, LF; Tsao, YP | 1 |
| Cotter, TG; Glynn, JM; Green, DR | 1 |
| Bertrand, R; Goldman, J; Kerrigan, D; Kohn, KW; Nieves-Neira, W; O'Connor, PM; Pommier, Y | 1 |
| Beardmore, C; D'Arpa, P; Liu, LF | 1 |
| Kaufmann, SH | 1 |
| Cotter, TG; Glynn, JM; Green, DR; Lennon, SV | 1 |
| Johnson, RT; Ryan, AJ; Squires, S; Strutt, HL | 2 |
| Dainiak, N; Hanspal, M; Kreczko, S; Strauss, PR | 1 |
| Hsiang, YH; Lihou, MG; Liu, LF | 1 |
| Covey, JM; Holm, C; Kerrigan, D; Pommier, Y | 1 |
| Dean, F; Hurwitz, J; Weissbach, L; Wobbe, CR | 1 |
| Beidler, DR; Cheng, YC | 1 |
| Bjornsti, MA; Evans, DL; Hall, DJ; Logan, TJ; Mercer, WE | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Cortés, F; Ortiz, T; Piñero, J | 1 |
| Kohn, KW; O'Connor, PM; Pommier, Y; Shimizu, T | 1 |
| Berger, NA; Chatterjee, S; Cheng, MF | 1 |
| Azuma, Y; Kizaki, H; Mizuno, Y; Onishi, Y; Sato, Y; Tadakuma, T | 1 |
| Duguet, M; Jaxel, C; Portemer, C; Taudou, G | 1 |
| Permana, PA; Snapka, RM | 1 |
| Báez, A; Casiano, CA; Pommier, Y; Tan, EM; Torres, K | 1 |
| Geller, HM; Morris, EJ | 1 |
| Cortés, F; López Baena, M; Ortiz, T; Piñero, J | 1 |
| Goldwasser, F; Hoki, Y; Jackman, J; Kohn, KW; O'Connor, PM; Pommier, Y; Shimizu, T | 1 |
| Falcieri, E; Falconi, M; Gobbi, P; Marhefka, G; Santi, S; Vitale, M; Zamai, L | 1 |
| Johnson, N; Ng, TC; Parkin, JM | 1 |
| Dorbic, T; Rich, A; Wittig, B; Wölfl, S | 1 |
| Kohlhagen, G; Kohn, KW; Nieves-Neira, W; Pommier, Y; Valenti, M; Wall, ME; Wani, MC | 1 |
| Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R | 1 |
| Brooker, DL; Ikegami, R; Rivera-Bennetts, AK; Yager, TD | 1 |
| Johnson, N; Ng, TT; Parkin, JM | 1 |
| Barale, R; Musio, A; Sbrana, I; Zavattari, P | 1 |
| Durka, S; Hueber, A; Weller, M | 1 |
| Anderson, M; Barrows, LR; D'Arpa, P; Holden, JA | 1 |
| Goldwasser, F; Kohn, KW; Pommier, Y; Torres, R; Valenti, M | 1 |
| Hunter, P; Ikegami, R; Yager, TD | 1 |
| Furuichi, Y; Goto, M; Heo, SJ; Nishikawa, K; Sakamoto, S; Shimamoto, A | 1 |
| Dahse, HM; Gräfe, U; Schlegel, B | 1 |
| Hapke, G; Rustum, YM; Tóth, K; Wu, J; Yin, MB | 1 |
| Gwadry, FG; Kohn, KW; Liu, ET; Miller, LD; Pommier, Y; Reinhold, WC; Scherf, U; Smith, LH; Weinstein, JN; Zhou, Y | 1 |
| Hara, O; Ikegami, S; Iwamatsu, T; Shibata, Y; Yamashita, M | 1 |
| Beerman, TA; Kuo, SR; Liu, JS; Melendy, T | 1 |
| Dong, YB; McMasters, KM; Yang, HL | 1 |
| Bushman, F; Groschel, B | 1 |
| Choi, VW; McCarty, DM; Samulski, RJ | 1 |
| Chen, AY; Erbele, T; Shih, SJ | 1 |
| Agama, K; Kohn, KW; Miao, ZH; Pommier, Y; Povirk, L; Sordet, O | 1 |
| Almasan, A; Fraizer, GC; Ray, S; Shyam, S | 1 |
| Gautier, J; Hoatlin, ME; Stone, S; Wang, LC | 1 |
| Arlt, MF; Glover, TW | 1 |
| Iwamatsu, T | 1 |
| Adachi, S; Anai, H; Hanada, K; Ishizaki, T; Kawano, M; Matsuoka, S; Nishida, M; Nishida, Y; Okuma, T; Tanaka, K; Terabayashi, T; Tomo, T; Tsumura, H | 1 |
2 review(s) available for camptothecin and aphidicolin
| Article | Year |
|---|---|
Induction of apoptosis in cells of the immune system by cytotoxic stimuli.
Topics: Animals; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Dactinomycin; Humans; Immune System; Necrosis | 1992 |
SV40 DNA replication intermediates: analysis of drugs which target mammalian DNA replication.
Topics: Animals; Aphidicolin; Camptothecin; DNA Replication; DNA Topoisomerases, Type II; DNA, Viral; Electrophoresis, Agar Gel; Mammals; Models, Genetic; Nucleic Acid Synthesis Inhibitors; Replicon; Simian virus 40; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Virus Replication | 1993 |
54 other study(ies) available for camptothecin and aphidicolin
| Article | Year |
|---|---|
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.
Topics: Aphidicolin; Camptothecin; CDC2 Protein Kinase; Cyclins; Dimethyl Sulfoxide; DNA Damage; DNA Replication; DNA Topoisomerases, Type I; G2 Phase; HeLa Cells; Humans; Kinetics; Methionine; Models, Biological; Neoplasm Proteins; Protamine Kinase; S Phase | 1992 |
Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle.
Topics: Animals; Aphidicolin; Camptothecin; Cell Cycle; Cell Death; Dactinomycin; Drug Resistance; Hybridomas; T-Lymphocytes | 1992 |
S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells.
Topics: Animals; Aphidicolin; Camptothecin; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA Polymerase II; DNA Replication; DNA, Neoplasm; Humans; Molecular Structure; S Phase; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1991 |
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.
Topics: Amsacrine; Animals; Antibiotics, Antineoplastic; Aphidicolin; Camptothecin; Cell Survival; Cricetinae; Cricetulus; Cycloheximide; Deoxyadenosines; Dichlororibofuranosylbenzimidazole; Diterpenes; DNA; Etoposide; Mutagens; Nucleic Acids; RNA; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1990 |
Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.
Topics: Amsacrine; Aphidicolin; Blotting, Western; Camptothecin; Colony-Forming Units Assay; Cycloheximide; Daunorubicin; Deoxyadenosines; Dichlororibofuranosylbenzimidazole; Diterpenes; DNA Polymerase II; DNA Replication; Drug Synergism; Etoposide; Female; Humans; Leukemia, Promyelocytic, Acute; Mutagens; RNA; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1991 |
Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.
Topics: Actin Cytoskeleton; Aphidicolin; Camptothecin; Cell Death; Cell Line; Cell Survival; Cytochalasin B; Humans; Ionomycin; Kinetics; Leukemia; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
[Isolation of drug-resistant mutant cells].
Topics: Alkylating Agents; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Aphidicolin; Camptothecin; Cell Separation; Drug Resistance; Etoposide; Humans; Hydroxamic Acids; Lovastatin; Monensin; Nucleic Acids; Teniposide; Toxins, Biological; Tunicamycin | 1991 |
Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.
Topics: Antiviral Agents; Aphidicolin; Camptothecin; Cell Division; Cell Line; Diterpenes; DNA; DNA Damage; DNA Replication; Electrophoresis, Agar Gel; Humans | 1991 |
DNA topoisomerase inhibitors block erythropoiesis and delay hemoglobinization in vitro.
Topics: Aphidicolin; Camptothecin; Cell Differentiation; Cell Division; Diterpenes; Erythrocytes; Erythropoiesis; Hemoglobins; Humans; In Vitro Techniques; Teniposide; Topoisomerase I Inhibitors | 1989 |
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.
Topics: Animals; Aphidicolin; Camptothecin; Cattle; Cell Survival; Diterpenes; DNA Damage; DNA Replication; DNA, Viral; Kinetics; Leukemia L1210; Mice; Simian virus 40; Thymus Gland; Topoisomerase I Inhibitors; Tumor Stem Cell Assay | 1989 |
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diterpenes; DNA Replication; Etoposide; Hydroxyurea; Kinetics; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1989 |
In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site.
Topics: Antigens, Viral, Tumor; Aphidicolin; Camptothecin; Diterpenes; DNA Replication; DNA, Circular; DNA, Viral; Female; HeLa Cells; Humans; In Vitro Techniques; Molecular Weight; Plasmids; Simian virus 40 | 1985 |
Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity.
Topics: Aphidicolin; Camptothecin; Cell Line; Colony-Forming Units Assay; Cycloheximide; DNA Adducts; DNA Damage; DNA Topoisomerases, Type I; Down-Regulation; Drug Resistance; Humans; Neoplasms; RNA; Topoisomerase I Inhibitors | 1995 |
Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins.
Topics: 3T3 Cells; Animals; Aphidicolin; Apoptosis; Bleomycin; Camptothecin; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; DNA Topoisomerases, Type I; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Etoposide; Mice; Retinoblastoma-Binding Protein 1; S Phase; Sequence Deletion; Transcription Factor DP1; Transcription Factors; Tumor Suppressor Protein p53 | 1995 |
Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA.
Topics: Aphidicolin; Camptothecin; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; Humans; In Vitro Techniques; RNA; Time Factors; Topoisomerase I Inhibitors; Ultraviolet Rays | 1993 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases.
Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; CHO Cells; Cricetinae; DNA Damage; DNA Replication; Electrophoresis, Gel, Pulsed-Field; Karyotyping; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1993 |
Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.
Topics: Aphidicolin; Apoptosis; Camptothecin; CDC2 Protein Kinase; Cyclins; DNA Damage; Enzyme Activation; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Mechlorethamine; Phosphorylation; S Phase; Tumor Cells, Cultured | 1995 |
Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Aphidicolin; Camptothecin; Carmustine; Cell Cycle; Cell Death; Cell Line; Cisplatin; Cricetinae; Cricetulus; DNA Damage; DNA Repair; DNA, Neoplasm; Doxorubicin; Drug Synergism; Etoposide; Fibroblasts; Hydroxyurea; Lung; Melphalan; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan | 1994 |
Topoisomerase inhibitors induce apoptosis in thymocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aphidicolin; Apoptosis; Azides; Camptothecin; Cell Survival; DNA; Etoposide; Isoquinolines; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred BALB C; Phorbol 12,13-Dibutyrate; Piperazines; Quinazolines; Quinazolinones; Sodium Azide; Thymus Gland; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Zinc | 1993 |
Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons.
Topics: Animals; Aphidicolin; Camptothecin; DNA; DNA Replication; Etoposide; Mice; Mice, Inbred C57BL; Spleen; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1993 |
Expression of proliferation-associated nuclear autoantigens, p330d/CENP-F and PCNA, in differentiation and in drug-induced growth inhibition using two-parameter flow cytometry.
Topics: Aphidicolin; Autoantigens; Camptothecin; Cell Cycle; Cell Differentiation; Centromere; Chromosomal Proteins, Non-Histone; DNA Replication; Etoposide; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Growth Inhibitors; HL-60 Cells; Humans; Microfilament Proteins; Proliferating Cell Nuclear Antigen; Tumor Cells, Cultured | 1996 |
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aphidicolin; Apoptosis; Astrocytes; Aurintricarboxylic Acid; Camptothecin; Cell Cycle; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA; DNA Topoisomerases, Type I; Enzyme Inhibitors; Models, Neurological; Neurons; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA; Stereoisomerism; Topoisomerase I Inhibitors | 1996 |
Sister chromatid exchange induced by DNA topoisomerases poisons in late replicating heterochromatin: influence of inhibition of replication and transcription.
Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; CHO Cells; Chromatin; Cricetinae; Dactinomycin; DNA Replication; Enzyme Inhibitors; Euchromatin; Heterochromatin; Isomerases; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic | 1996 |
Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Camptothecin; Carcinoma; CDC2 Protein Kinase; Colonic Neoplasms; Cyclins; DNA Damage; DNA Repair; DNA Replication; Enzyme Inhibitors; G2 Phase; Humans; S Phase; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1996 |
Anti-BrdUrd labeling of newly synthesized DNA in HL-60 cells triggered to apoptosis.
Topics: Antibodies, Monoclonal; Aphidicolin; Apoptosis; Bromodeoxyuridine; Camptothecin; DNA, Neoplasm; HL-60 Cells; Humans; Time Factors; Topoisomerase I Inhibitors | 1996 |
Induction of apoptosis within T lymphoblastoid cells by a topoisomerase I inhibitor.
Topics: Aphidicolin; Apoptosis; Camptothecin; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Jurkat Cells; Kinetics; RNA, Neoplasm; T-Lymphocytes; Time Factors; Topoisomerase I Inhibitors | 1997 |
Identification of processes that influence negative supercoiling in the human c-myc gene.
Topics: Amanitins; Aphidicolin; Camptothecin; Cell Line; DNA Polymerase I; DNA, Superhelical; Genes, myc; Humans; Molecular Conformation; Polymerase Chain Reaction; Restriction Mapping | 1997 |
Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Base Sequence; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Topoisomerases, Type I; Humans; Molecular Sequence Data; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors | 1997 |
Effect of inhibitors of DNA replication on early zebrafish embryos: evidence for coordinate activation of multiple intrinsic cell-cycle checkpoints at the mid-blastula transition.
Topics: Animals; Aphidicolin; Blastocyst; Camptothecin; Cell Cycle; DNA Replication; Embryo, Nonmammalian; Etoposide; Gene Deletion; Mutagenesis; Time Factors; Zebrafish | 1997 |
Camptothecin causes cell cycle perturbations within T-lymphoblastoid cells followed by dose dependent induction of apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Cell Survival; DNA Fragmentation; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Jurkat Cells; Kinetics; RNA; T-Lymphocytes | 1997 |
Common fragile sites on human chromosomes represent transcriptionally active regions: evidence from camptothecin.
Topics: Adult; Aphidicolin; Camptothecin; Cells, Cultured; Chromatin; Chromosome Breakage; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Humans; Male; Topoisomerase I Inhibitors; Transcription, Genetic | 1998 |
CD95-mediated apoptosis: no variation in cellular sensitivity during cell cycle progression.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Cell Death; Cisplatin; Culture Media, Serum-Free; Doxorubicin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Gene Expression; HeLa Cells; Humans; Hydroxyurea; Jurkat Cells; Membrane Glycoproteins; Nimustine; Nocodazole; Paclitaxel; Sensitivity and Specificity; Teniposide; Tumor Cells, Cultured; Vincristine | 1998 |
The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.
Topics: Animals; Aphidicolin; Blotting, Western; Camptothecin; Cell Survival; CHO Cells; Cricetinae; DNA Ligase ATP; DNA Ligases; DNA Replication; DNA Topoisomerases, Type I; DNA-Binding Proteins; Gene Deletion; Mutation; Poly-ADP-Ribose Binding Proteins; S Phase; Topoisomerase I Inhibitors; X-ray Repair Cross Complementing Protein 1; Xenopus Proteins | 1998 |
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
Topics: Antineoplastic Agents; Aphidicolin; Camptothecin; Cisplatin; DNA; DNA Damage; DNA, Single-Stranded; Drug Synergism; Female; Humans; S Phase; Tumor Cells, Cultured | 1996 |
Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo.
Topics: Animals; Aphidicolin; Apoptosis; Blastocyst; Camptothecin; Caspases; Cell Cycle; Cell Division; Cell Lineage; Cell Membrane; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA Fragmentation; DNA Replication; Embryo, Nonmammalian; Enzyme Inhibitors; Gastrula; Hydroxyurea; In Situ Nick-End Labeling; Isoenzymes; Mammals; Microscopy, Confocal; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Species Specificity; Stress, Physiological; Topoisomerase I Inhibitors; Xenopus laevis; Zebrafish | 1999 |
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.
Topics: 4-Nitroquinoline-1-oxide; Aphidicolin; Bleomycin; Camptothecin; Cell Line; Cell Nucleus; DNA Damage; DNA Helicases; DNA Replication; DNA-Binding Proteins; Dose-Response Relationship, Drug; Etoposide; Humans; Immunoblotting; Immunohistochemistry; In Situ Hybridization, Fluorescence; Mutagens; Proteins; Rad51 Recombinase; Trans-Activators; Werner Syndrome | 2001 |
Differentiation between inducers of apoptosis and nonspecific cytotoxic drugs by means of cell analyzer and immunoassay.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Aphidicolin; Apoptosis; Camptothecin; Cell Count; Cell Division; Cell Size; Cytological Techniques; Enzyme-Linked Immunosorbent Assay; Humans; Immunoassay; Tumor Cells, Cultured | 2001 |
Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin.
Topics: Aphidicolin; Apoptosis; Camptothecin; Cell Division; DNA Damage; DNA Fragmentation; DNA Ligases; DNA Repair; DNA Topoisomerases, Type I; Drug Interactions; Electrophoresis, Gel, Pulsed-Field; Enzyme Activation; Enzyme Inhibitors; Humans; Irinotecan; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 2002 |
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects.
Topics: Aphidicolin; Camptothecin; Cell Cycle; Colonic Neoplasms; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, cdc; Humans; Mitosis; Oligonucleotide Array Sequence Analysis; Topoisomerase I Inhibitors; Transcription, Genetic | 2002 |
Studies on fertilization in the teleost IV. Effects of aphidicolin and camptothecin on chromosome formation in fertilized medaka eggs.
Topics: Animals; Aphidicolin; Camptothecin; Chromosomes; DNA Polymerase I; DNA Topoisomerases; Etoposide; Fertilization; Meiosis; Mitogen-Activated Protein Kinases; Mitosis; Naphthoquinones; Oryzias; Protein Kinases; Topoisomerase Inhibitors; Zygote | 2002 |
Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks.
Topics: Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Aphidicolin; Benzofurans; Camptothecin; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; DNA Replication; Duocarmycins; Enediynes; HeLa Cells; Humans; Indoles; S Phase | 2003 |
E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Phytogenic; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Colorectal Neoplasms; Combined Modality Therapy; DNA Topoisomerases, Type I; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Genes, p53; Genetic Therapy; Genetic Vectors; Humans; Male; Mice; Mice, Inbred BALB C; Topoisomerase I Inhibitors; Transcription Factors | 2003 |
Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virus.
Topics: Aphidicolin; Camptothecin; Cell Cycle; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; G2 Phase; HIV; HIV Infections; Humans; Nucleic Acid Synthesis Inhibitors; Paclitaxel; Time Factors; Transduction, Genetic; Virus Replication | 2005 |
Effects of adeno-associated virus DNA hairpin structure on recombination.
Topics: Aphidicolin; Base Sequence; Camptothecin; Dependovirus; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Circular; DNA, Viral; Etoposide; Genes, Reporter; Genetic Vectors; Genome, Viral; HeLa Cells; Humans; Hydroxyurea; Nucleic Acid Conformation; Recombination, Genetic; Terminal Repeat Sequences | 2005 |
Ku86 modulates DNA topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian cells.
Topics: Animals; Antigens, Nuclear; Antineoplastic Agents; Aphidicolin; Camptothecin; CHO Cells; Cricetinae; DNA; DNA Replication; DNA Topoisomerases, Type I; DNA-Binding Proteins; Fibroblasts; Humans; Ku Autoantigen; Radiation Tolerance; Transfection | 2005 |
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.
Topics: Aphidicolin; Camptothecin; Cell Line; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; Humans; Phosphoric Diester Hydrolases; Spinocerebellar Ataxias; Transcription, Genetic | 2006 |
S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aphidicolin; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA-Binding Proteins; Down-Regulation; Drug Synergism; Enzyme Activation; Humans; Irinotecan; Ligands; Male; Mice; Prostatic Neoplasms; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, TNF-Related Apoptosis-Inducing Ligand; S Phase; TNF-Related Apoptosis-Inducing Ligand; Transplantation, Heterologous; Tumor Suppressor Proteins | 2007 |
Fanconi anemia proteins stabilize replication forks.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Nucleus; Cell-Free System; Chromatin; DNA Damage; DNA Repair; DNA Replication; Enzyme Inhibitors; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group L Protein; Mitomycin; Phosphorylation; Protein Serine-Threonine Kinases; Xenopus laevis; Xenopus Proteins | 2008 |
Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.
Topics: Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Betulinic Acid; Camptothecin; Cell Cycle Proteins; Cell Nucleus; Checkpoint Kinase 1; Chromosome Breakage; Chromosome Fragile Sites; DNA Replication; DNA, Single-Stranded; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Pentacyclic Triterpenes; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; Topoisomerase I Inhibitors; Triterpenes; Ubiquitination | 2010 |
Chromosome Formation During Fertilization in Eggs of the Teleost Oryzias latipes.
Topics: Animals; Aphidicolin; Camptothecin; Cell Proliferation; DNA Replication; DNA Topoisomerases, Type I; DNA-Directed DNA Polymerase; Eggs; Female; Fertilization; Immunoblotting; Meiosis; Oocytes; Oryzias | 2017 |
Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.
Topics: Aphidicolin; Arginine; Asparagine; Camptothecin; DNA; DNA Topoisomerases, Type I; Naphthyridines; Tyrosine | 2022 |