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camptothecin and 7-ethyl-7-hydroxy-10h-1,3-dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7h,12h)-dione

camptothecin has been researched along with 7-ethyl-7-hydroxy-10h-1,3-dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7h,12h)-dione in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's4 (44.44)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Nicholas, AW; Wall, ME; Wani, MC1
Burke, TG; Mi, Z1
Besterman, JM; Leitner, P; Manikumar, G; Moore, L; Nicholas, AW; Tele, C; Truesdale, A; Wall, ME; Wani, MC1
Del Rio, M; Gongora, C; Jin, C; Lam, H; Li, F; Ling, X; Wani, M; Welch, J; Westover, D1
Ji, L; Jiang, G; Liu, R; Liu, Z; Ma, Q; Yang, Y; Yang, Z; Zhao, H1
Li, F; Li, Q; Weng, Q; Xia, L; Zhang, X; Zheng, Y; Zhou, L1
Gao, H; Gao, M; Jiang, G; Lin, X; Su, Q; Tong, J; Yang, Z; Zhang, A; Zhang, X1
Guan, H; Jiang, T; Liu, J; Liu, X; Wang, X; Wu, G; Yin, R; Yu, M; Yu, R; Zhang, Y1
Feng, K; Jiang, T; Lv, Z; Yu, M; Zhang, J; Zhang, Y1

Other Studies

9 other study(ies) available for camptothecin and 7-ethyl-7-hydroxy-10h-1,3-dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7h,12h)-dione

ArticleYear
Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:11

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Leukemia L1210; Solubility; Structure-Activity Relationship

1986
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan

1994
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
    Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18

    Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Humans; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1993
FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance.
    Molecular cancer, 2015, Apr-28, Volume: 14

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzodioxoles; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colorectal Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Female; Gene Silencing; Humans; Indolizines; Irinotecan; Lung Neoplasms; Mice, SCID; Neoplasm Proteins; Topoisomerase Inhibitors; Treatment Outcome; Xenograft Model Antitumor Assays

2015
FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
    Bioscience trends, 2018, Volume: 12, Issue:1

    Topics: Benzodioxoles; beta Catenin; Breast Neoplasms; Cadherins; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D; Epithelial-Mesenchymal Transition; Female; Humans; Indolizines; Inhibitor of Apoptosis Proteins; Neoplasm Invasiveness; Survivin; Vimentin; Wnt Signaling Pathway

2018
In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models.
    Cancer chemotherapy and pharmacology, 2019, Volume: 84, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzodioxoles; Biological Transport; Camptothecin; Cell Proliferation; HCT116 Cells; Hep G2 Cells; Humans; In Vitro Techniques; Indolizines; Neoplasms

2019
FL118 inhibits viability and induces apoptosis of colorectal cancer cells via inactivating the CIP2A/PP2A axis.
    Life sciences, 2019, Dec-15, Volume: 239

    Topics: Animals; Apoptosis; Autoantigens; Benzodioxoles; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; China; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Indolizines; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays

2019
Self-assembling nanoparticles of dually hydrophobic prodrugs constructed from camptothecin analogue for cancer therapy.
    European journal of medicinal chemistry, 2020, Aug-15, Volume: 200

    Topics: Animals; Benzodioxoles; Camptothecin; Chromones; Disulfides; Drug Stability; Humans; Hydrophobic and Hydrophilic Interactions; Indolizines; Lipids; Nanomedicine; Nanoparticles; Neoplasms; Prodrugs

2020
Simultaneous determination of FL118 and W34 in rat Blood by LC-MS/MS: Application to pharmacokinetic studies.
    Biomedical chromatography : BMC, 2020, Volume: 34, Issue:11

    Topics: Animals; Benzodioxoles; Camptothecin; Chromatography, Liquid; Indolizines; Limit of Detection; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry

2020