camptothecin has been researched along with 10-hydroxycamptothecin in 275 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (6.18) | 18.7374 |
| 1990's | 21 (7.64) | 18.2507 |
| 2000's | 79 (28.73) | 29.6817 |
| 2010's | 137 (49.82) | 24.3611 |
| 2020's | 21 (7.64) | 2.80 |
| Authors | Studies |
|---|---|
| Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL | 1 |
| Nicholas, AW; Wall, ME; Wani, MC | 1 |
| Lindley, JT; Ronman, PE; Wall, ME; Wani, MC | 1 |
| Burke, TG; Mi, Z | 2 |
| Besterman, JM; Leitner, P; Manikumar, G; Moore, L; Nicholas, AW; Tele, C; Truesdale, A; Wall, ME; Wani, MC | 1 |
| Bingcang, AL; Bom, D; Burke, TG; Chavan, AJ; Curran, DP; Du, W; Fraley, KA; Kohlhagen, G; Kruszewski, S; Latus, LJ; Pommier, Y; Thompson Strode, J; Zimmer, SG | 1 |
| Choe, YH; Greenwald, RB; Wu, D | 1 |
| Jiang, C; Jin, W; Li, M; Lou, L; Tang, W; You, T; Zheng, C | 1 |
| Chen, XG; Chern, JW; Guo, QL; He, XG; Huang, CH; Li, TK; Li, ZY; Wang, XJ; Yang, Q; You, QD | 1 |
| Chen, SB; Gu, LQ; Huang, SL; Huang, ZH; Huang, ZS; Li, D; Ou, JB; Ou, TM; Shen, LL; Tan, JH; Wu, WB | 1 |
| Chen, Y; Huang, Q; Lu, W; Luo, Y; Tong, L; Yu, S | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Abasolo, I; Bermejo, M; Cabañas, MJ; Corma, A; Gonzalez-Alvarez, I; Gonzalez-Alvarez, M; Mangas-Sanjuán, V; Rodriguez-Berna, G; Schwartz, S | 1 |
| Ge, R; Guo, Q; Li, Z; Lu, L; Xie, Z; Zhao, L; Zhao, Q | 1 |
| Deng, T; Jiang, ZX; Mao, X; Xiao, Y; Yang, Z; Zheng, X | 1 |
| Chen, W; Fu, K; Hu, J; Huang, W; Jiang, Z; Li, M; Shi, Y; Ye, W; Zhou, C; Zhou, W | 1 |
| Shu, RS; Wang, ZW; Xu, B | 1 |
| Ling, YH; Nelson, JA; Tseng, MT | 1 |
| Qi, XD; Tang, WD; Tu, ZH; Wang, MY; Xiao, WQ | 1 |
| Andersson, BS; Ling, YH; Nelson, JA | 1 |
| Liu, J; Xu, B; Yang, SL | 1 |
| Cheng, YC; Hwang, BD; Liu, SY; Liu, ZC | 1 |
| Ling, YH; Xu, B; Zhao, CS | 1 |
| Shen, ZM; Wang, XW; Xu, B; Yang, JL; Yu, WJ | 1 |
| Chen, RL; Gu, HM; Xi, GL; Zhu, MY | 1 |
| Ling, YH; Shen, CY; Shi, QL; Xu, B | 1 |
| Shen, ZM; Wang, XW; Xu, B; Yang, JL | 1 |
| Ling, YH; Xu, B | 2 |
| Ling, YH; Xu, B; Yu, WJ | 2 |
| Han, JX; Shen, ZM; Xu, B; Yang, JL | 1 |
| Han, JX; Xu, B; Yang, JL | 1 |
| Creasey, WA; Gil, D; Richards, M; Tsou, KC | 1 |
| Xu, B | 1 |
| Lo, KW; Miller, EE; Tsou, KC; Xu, B | 1 |
| Yu, ZJ | 1 |
| Li, YF; Zhang, R | 1 |
| Burke, TG; Schwendeman, SP; Shenderova, A | 2 |
| Cai, Q; Chambless, B; Li, Y; Liu, T; Sun, H; Zhang, R | 1 |
| Liu, W; Zhang, R | 1 |
| Aimi, N; Chiba, K; Hosokawa, M; Satoh, T; Takayama, H; Watanabe, A | 1 |
| Li, N; Ou, Q; Shen, B; Wang, H; Yu, B; Zhang, H; Zheng, M | 1 |
| Qing, C; Xu, B; Zhang, XW | 1 |
| Fan, J; Tang, X; Zhang, X | 1 |
| Xu, B; Zhang, XW | 1 |
| Jiang, JF; Xu, B; Zhang, XW | 1 |
| Shen, K; Sun, Z; Xu, X | 1 |
| Ding, J; Li, M; Tan, W; Xiao, D | 1 |
| Agrawal, S; Nan, L; Wang, H; Yu, D; Zhang, R | 1 |
| Hamilton, G; Jäger, W; Platzer, P; Reznicek, G; Thalhammer, T; Zhang, R | 1 |
| Liu, J; Xu, B; Zhou, JJ | 1 |
| Xu, B; Zhang, X; Zhou, Y | 1 |
| Wang, L; Yang, W | 1 |
| Fan, J; Ling, G; Tang, X; Wang, X; Wang, Y; Xu, D; Zhang, X | 1 |
| Jia, ZP; Liu, CL; Ma, J; Wang, R; Xu, LT; Zhu, PL | 1 |
| Agrawal, S; Lindsey, JR; Nan, L; Wang, H; Yu, D; Zhang, R | 1 |
| Huang, HX; Li, GS; Yang, CX | 1 |
| Chen, LM; Ding, Y; Fu, LW; Liang, YJ; Pan, QC; Xiong, HY; Yang, XP | 1 |
| Chai, LP; Su, ZZ; Xian, ZX | 1 |
| Chen, ZH; Feng, B | 1 |
| Lorence, A; Medina-Bolivar, F; Nessler, CL | 1 |
| Fan, JJ; Jia, ZP; Jiang, NX; Ma, J; Wang, J; Wang, R; Xie, H; Zhang, Q | 1 |
| Chen, Q; Guan, ZZ; He, YJ; Hu, XH; Huang, HQ; Jiang, WQ; Li, YH; Lin, XB; Lin, Z; Liu, KF; Shen, WX | 1 |
| Azrak, RG; Cao, S; Durrani, FA; Frank, C; Li, ZR; Rustum, YM; Yin, MB | 1 |
| Li, YL; Qin, QL; Qu, X; Song, WG; Wu, C; Xu, YP | 1 |
| Cai, J; Ding, J; He, X; Jiang, X; Lu, W; Zhang, X | 1 |
| Danks, MK; Hyatt, JL; Lee, RE; Morton, CL; Potter, PM; Yoon, KJ | 1 |
| Ashkenazi, S; Huppert, D; Leiderman, P; Solntsev, KM; Sullivan, EN; Tolbert, LM | 1 |
| Fu, YJ; Li, QY; Liu, Q; Zhang, Y; Zu, YG | 1 |
| Chen, J; Fang, Y; Huang, LL; Liu, BR; Qian, XP; Zhang, HX | 1 |
| Cai, X; Guo, YW; Lin, F; Sun, YJ; Tang, XC; Yao, Y; Zhao, H | 2 |
| Ji, J; Ji, YB; Lin, YZ; Liu, BY; Yuan, F; Zhang, J; Zhu, ZG | 1 |
| Fan, Y; Feng, YQ; Wen, Y; Zhang, M | 1 |
| Fu, ZD; Li, DZ; Liu, HY; Pan, XD; Wang, CY; Wu, S | 1 |
| Jiang, W; Larrick, JW; Li, L; Wang, Y | 1 |
| Cai, W; Chen, JP; Li, XY; Wu, XY; Yao, DF; Yu, JW; Yu, ZJ; Yuan, HX; Yuan, Y | 1 |
| Jin, W; Li, N; Lin, XX; Lou, F; Pan, HM; Wu, JM; Ye, M; Zheng, Y | 1 |
| Huang, MZ; Xu, CY; Xue, CX | 1 |
| Fang, C; Hong, MH; Pei, YY; Shi, B; You, MX | 1 |
| Chi, CW; Ho, LK; Lee, HC; Lee, JY; Lu, MF; Ping, YH; Wang, JJ; Wu, PH | 1 |
| Feng, LF; Lei, XY; Liao, DF; Tang, SS; Zhong, M; Zhu, BY | 1 |
| Fu, YR; Qiu, ZY; Yan, YR | 1 |
| Hou, LB; Jiang, QF; Wang, CX; Xi, N; Yan, XQ | 1 |
| Gao, K; Li, X; Pan, J | 1 |
| Guo, W; Qiu, WL; Yu, Y; Zhou, XJ | 1 |
| Fang, C; Pei, Y; Shi, B | 1 |
| Chan, SA; Hsieh, TF; Lin, SY; Wang, SL | 1 |
| Leu, YL; Prijovich, ZM; Roffler, SR | 1 |
| Cai, X; Guo, YW; Lin, F; Sun, YJ; Tang, LN; Tang, XC; Yao, Y; Zhang, W; Zhao, H | 1 |
| Geng, M; Ji, YB; Jiang, JS; Li, H; Lou, GY; Ma, T; Xi, WQ; Xia, HQ; YeE, ZB | 1 |
| Ding, Y; Ping, Q; Yu, LL; Zhang, C | 1 |
| Ewis, HE; Liu, P; Lu, CD; Tai, PC; Weber, IT | 1 |
| Bordovská, S; Meloun, M; Vrána, A | 1 |
| Guo, R; Jiang, X; Li, Y; Liu, B; Wang, Q; Yang, C; Yang, M; Zhang, L | 1 |
| Cui, F; Cun, D; Lin, W; Shi, K; Tao, A; Yang, L | 1 |
| Chen, H; Gao, J; Liang, W; Sun, X; Wu, L; Zhao, Y | 1 |
| Chen, D; Chen, Y; Ding, XQ; Li, S; Wang, AX; Wang, J | 1 |
| Fu, YR; Qiu, ZY; Yan, YR; Yi, ZJ | 1 |
| Cyrankiewicz, M; Kruszewski, S; Ziomkowska, B | 2 |
| Chen, CS; Chern, JW; Leu, YL; Wu, YJ | 1 |
| Gan, L; Gan, Y; Nie, SF; Pan, WS; Yang, XG; Zhang, XX; Zhu, CL | 1 |
| Cai, XM; Gu, JR; Jiang, H; Li, ZH; Shi, BZ; Zhang, J | 1 |
| Li, S; Wang, A | 1 |
| Gao, K; He, Y; He, Z; Liu, K; Sun, J; Wang, Y | 1 |
| Li, Y; Liu, Y; Lu, A; Wang, S; You, Q | 1 |
| Gan, L; Gan, Y; Nie, S; Pan, W; Zhang, X | 1 |
| Chen, P; Lin, F; Sun, Y; Tang, L; Yao, Y; Zhao, H | 1 |
| Cao, X; Liu, B; Sun, S; Sun, Y; Wang, L; Wu, N | 1 |
| Cai, XM; Liu, MZ; Xie, HL; Zha, XL | 1 |
| Dong, QL; Liu, GS; Yao, YS; Yao, ZJ | 1 |
| Gan, L; Gan, Y; Nie, S; Pan, W; Zhang, X; Zhu, C | 1 |
| Li, L; Tan, Y; Wang, Y; Yang, X | 1 |
| Kusari, S; Spiteller, M; Zühlke, S | 1 |
| Li, JH; Shi, WG; Yang, L; Zhao, CJ; Zu, YG | 1 |
| Chen, H; Ding, F; Jiang, G | 1 |
| Pan, BH; Shi, SW; Song, H; Tang, YM; Yang, SL; Yuan, ZF; Zhao, FY | 1 |
| Han, J; He, Z; Liu, X; Pan, W; Pu, X; Sun, J; Tang, X; Wang, Y; Zhang, P | 1 |
| Li, LB; Wang, J; Wang, R | 1 |
| Bian, X; Ding, D; Hu, Y; Jia, Z; Jiang, X; Li, R; Li, X; Wu, W; Zhu, Z | 1 |
| Mohana Kumar, P; Priti, V; Ramesha, BT; Ravikanth, G; Shweta, S; Spiteller, M; Uma Shaanker, R; Vasudeva, R; Zuehlke, S | 1 |
| Cui, F; Jiang, Y; Shi, K; Tian, Y; Wang, L | 1 |
| Chen, W; Deng, B; Ding, X; Liu, K | 1 |
| Gong, T; Liu, J; Ren, K; Shi, SJ; Sun, X; Wei, W; Zhang, XN; Zhang, ZR; Zhao, D | 1 |
| Cui, W; Li, X; Luo, X; Xie, C; Yang, Y; Zhou, S; Zou, J | 1 |
| Chirieac, LR; Colson, YL; Grinstaff, MW; Liu, R; Walpole, J; Wolinsky, JB | 1 |
| Du, YZ; Hu, FQ; Wang, L; Yuan, H; Zhou, JP; Zhou, YY | 1 |
| Li, M; Suo, X; Wang, Y; Zhu, S | 1 |
| Chen, B; Zhang, X | 1 |
| Feng, G; Li, X; Liang, B; Liang, H; Qian, J; Wang, Y; Wu, H; Zhao, H; Zheng, C | 1 |
| Fang, Y; Hu, W; Lou, C; Zhang, C | 1 |
| Li, L; Li, N; Wang, J; Yang, X | 1 |
| Lin, J; Liu, SX; Meng, XX; Shao, XQ; Wu, XM; Xiao, HS; Zhang, XN; Zhu, L | 1 |
| Guo, B; Guo, XM; Sun, X; Zhang, Q | 1 |
| Liu, J; Ni, B; Yang, J; Zhou, W; Zhu, L | 1 |
| Chen, YH; Ding, L; Huo, S; Lu, Q; Renegar, R; Wang, X; Zhang, G | 1 |
| Gong, Y; Hou, R; Jiang, K; Lin, J; Pi, Y; Sun, X; Tang, K | 1 |
| Gao, Y; Li, Q; Liu, C; Su, L; Sun, B; Wang, Y; Zhang, B; Zhao, D; Zhao, Q; Zhao, X; Zu, Y | 1 |
| Dai, Z; Dong, J; Guo, N; Guo, S; Jing, L; Wang, Y; Yan, X; Yue, X; Zheng, J | 1 |
| Jiang, X; Wu, W | 1 |
| Jiang, R; Li, Q; Li, Y; Sun, Z; Wang, Y; Zhang, B; Zhang, X; Zhao, D; Zhao, X; Zu, B; Zu, Y | 1 |
| Gan, L; Gan, Y; Gao, Y; Zhang, XX; Zhu, CL | 1 |
| Huang, A; Niu, J; Ping, Q; Sang, X; Su, Z; Sun, M; Xiao, Y; You, W; Yuan, D | 1 |
| Hua, HY; Liu, WJ; Wang, L; Zhang, ZZ; Zhao, YX | 1 |
| Feng, G; Liang, B; Liang, H; Qian, J; Wang, Y; Zhao, H; Zheng, C | 1 |
| He, Z; Pu, X; Sun, J; Sun, Y; Wang, Y; Zhang, P | 1 |
| Liu, Y; Sun, HH; Yang, LY; Yuan, LL; Zhang, J; Zhang, YZ | 1 |
| Colson, YL; Grinstaff, MW; Wolinsky, JB; Yohe, ST | 1 |
| Chen, SZ; Shang, BY; Shang, Y; Zhen, YS | 1 |
| Li, X; Liu, C; Luo, X; Wang, H; Xie, C; Yan, S | 1 |
| Dai, Z; Guo, H; Guo, N; Jing, L; Ma, W; Wang, Y; Wang, Z; Yan, X; Zhang, R; Zheng, J | 1 |
| Chang, D; Hou, Z; Jiang, Q; Li, L; Li, Y; Xie, L; Yang, X; Ye, S; Zhan, C; Zhang, Q; Zhu, P | 1 |
| Du, J; Qian, C; Tang, W; Yuan, Z; Zhang, Y | 1 |
| An, F; Diao, X; Hao, X; Li, W; Liu, Z; Wang, C; Yang, Y; Zhang, X | 1 |
| Li, P; Lin, Y; Ran, H; Ren, J; Tan, J; Wang, Z; Zhang, Q; Zheng, Y | 1 |
| Hu, Z; Shao, C; Wang, D; Wang, Y; Yan, X; Yu, T; Zhang, R; Zheng, J | 1 |
| Lang, M; Wang, Y; Xia, L; Yu, P; Zhang, G; Zhang, Z; Zhao, J | 1 |
| Jia, G; Li, X; Luo, X; Song, H; Xu, G; Yan, S; Yang, S | 1 |
| Ding, GB; Guo, Y; Liu, HY; Liu, XF; Lv, YY; Sun, CK; Xu, L | 1 |
| Huang, F; Jing, GL; Qu, JB; Shao, HH | 1 |
| Wang, LP; Wei, YJ | 1 |
| Chen, ZH; Guo, CP; Li, RH; Zhang, GJ; Zhao, RJ | 1 |
| Cao, J; Cui, S; Gu, Y; Qian, Z; Zhu, H | 1 |
| Chen, J; Chen, X; Ding, J; He, C; Li, M; Xiao, C; Zhang, Y; Zhuang, X | 1 |
| Hu, J; Li, X; Liu, Z; Lu, Z; Sun, Y; Wang, J; Wang, Q; Yan, L | 1 |
| Jiang, Q; Liu, J; Luo, X; Yang, Z; Zhang, X | 1 |
| Deng, Y; Ge, Y; Meng, L; Yu, X; Zhang, Y; Zhao, X; Zu, Y | 1 |
| Gan, L; Gan, Y; Gao, YP; Zhang, XX; Zhu, CL | 1 |
| Chi, AL; Fei, B; Weng, Y | 1 |
| Chen, Q; He, H; Pan, G; Xiong, L; Yang, H | 1 |
| Jie, J; Liu, Z; Tian, B; Yang, Y; Zhang, X; Zhou, M | 1 |
| Cai, C; Li, G; Ren, T; Tang, X | 1 |
| Hao, X; Jie, J; Yang, Y; Yu, C; Zhang, X; Zhou, M | 1 |
| Hu, HH; Song, HX | 1 |
| Ge, L; Wang, J; Wang, Y; Xu, H; Zhu, J | 1 |
| Chen, Z; Feng, Y; Guo, R; He, M; Hong, Z; Kong, X; Li, M; Li, Y; Tian, R; Wang, J; Wu, W; Yu, K; Yu, M | 1 |
| Chu, L; Ding, D; Kong, D; Liu, J; Xu, H; Yang, C; Yang, Z; Zhang, Y | 1 |
| Hao, X; Jie, J; Li, W; Tian, B; Yu, C; Zhang, X; Zhou, M | 1 |
| Hu, YF; Lu, C; Pan, C; Pan, MH; Song, J; Wang, L; Yi, HS | 1 |
| Cai, J; Chen, H; Feng, X; He, J; Hu, J; Li, X; Liang, Y; Sun, Y; Sun, Z; Wang, J; Xiao, H; Xiong, C; Yan, L; Yu, H | 1 |
| Fan, B; Li, S; Liu, Y; Shao, C; Wang, Y; Zheng, J | 1 |
| Xu, FJ; Yang, X; Zhao, N | 1 |
| Cai, C; Li, G; Li, Y; Tang, X; Tang, Y; Xu, H; Yin, T; Zhang, Y | 1 |
| Ding, GB; Guo, Y; Wang, Y; Xu, L | 1 |
| Li, G; Pan, X; Qin, LZ; Wu, CB; Wu, LN; Zhang, J; Zhang, X | 1 |
| Dong, N; Lü, Y; Yang, LF | 1 |
| Dong, M; Ju, D; Li, J; Li, Y; Liu, Z; Meng, G; Tan, H; Wang, G; Zhang, Q | 1 |
| Bai, J; Bian, Z; Chen, F; Fu, S; Guan, R; Jin, Y; Quan, C; Sun, W; Wu, J; Xu, L; Yu, Y | 1 |
| Tian, B; Yu, C; Zhang, X; Zhou, M | 1 |
| Li, X; Liang, Y; Sun, Y; Wang, J; Xiao, T; Yan, L; Zhu, G | 1 |
| Chen, Q; Li, P; Wang, S; Xie, X; Yu, F | 1 |
| Cao, Y; Chen, D; Chen, X; He, H; Liu, M; Wang, C; Wen, Z | 1 |
| Guo, N; Jiang, D; Teng, YO; Wang, L; You, X; Yu, P | 1 |
| Chen, M; Li, X; Lu, J; Luo, X; Wei, J | 1 |
| Gong, W; Li, B; Li, M; Li, Y; Li, Z; Mei, X; Wang, Z; Xie, X; Yang, Y; Yang, Z; Yu, F; Zhang, H | 1 |
| Gu, Y; Huang, Y; Li, G; Mei, L; Pan, X; Qin, L; Shan, Z; Wu, C | 1 |
| Chen, F; Li, C; Li, Z; Liang, XJ; Ma, X; Okeke, CI; Pan, Y; Peng, L; Wang, PC; Wang, Y; Xue, X; Zhao, Y | 1 |
| Di, J; Hong, J; Jiang, J; Kuang, H; Liao, Y; Wang, X; Yang, L | 1 |
| Mao, S; Shi, C; Sun, Y; Tian, Y; Wang, J; Wang, L; Yang, J; Zhang, X; Zhang, Y | 1 |
| Cao, Y; Chen, D; Chen, S; He, H; Huang, X; Lei, S; Liu, M; Luo, S; Mukerabigwi, JF; Wen, Z; Zhang, Y | 1 |
| Chen, X; Nan, X; Yu, C; Zhang, X; Zhou, M | 1 |
| Chen, C; Chen, Y; Xiao, Y; Zhang, X | 1 |
| Dai, L; Hou, Z; Huang, Y; Li, Y; Lin, J; Wu, H; Wu, S; Xie, L; Yang, X | 1 |
| Guo, Q; Yuan, Q | 1 |
| Li, SS; Tang, YM; Xu, XJ; Yuan, ZF; Zhang, JY | 1 |
| Dai, Z; Jing, L; Shao, S; Wang, Y; Yang, Y; Yue, X | 1 |
| Chen, B; Feng, J; Jiang, Y; Liu, G; Wang, H; Xie, Q | 1 |
| Ren, L; Sun, X; Wang, S; Wang, Y; Yang, H; Zhang, L; Zhang, M | 1 |
| Hu, YF; Lu, C; Pan, C; Pan, MH; Song, J; Wang, L; Wang, YP; Yang, YY; Yi, HS; Zhang, M | 1 |
| Bao, H; Xu, H; Yan, Z; Zhang, Q | 1 |
| Guo, Y; Han, M; Kuang, H; Liu, Y; Wang, X; Yang, X; Zhao, Y | 1 |
| Ci, T; Cui, S; Ding, J; Liu, R; Shen, Y; Yu, L | 1 |
| Dong, Z; Guo, Y; Han, M; Li, R; Wang, T; Wang, X; Zhao, Y; Zhu, C | 1 |
| Chen, J; Chen, X; Ding, J; Guo, H; Hou, Y; Xu, W; Yan, L | 1 |
| Fan, Z; Hou, Z; Jiang, Y; Li, Y; Lu, Y; Wu, S; Yang, X | 1 |
| Li, J; Oupický, D; Ping, Q; Qiao, H; Su, Z; Sun, M; Xie, Y; Zhang, C | 1 |
| Cai, Y; Dai, L; Gao, J; Lin, M; Liu, J; Ren, C; Shen, H; Shi, Y; Yang, Z; Zhan, J | 1 |
| Chen, D; Deng, H; Huang, P; Jin, X; Sun, P; Wang, N; Zhu, X | 1 |
| Du, Y; Fu, Z; He, R; Ismail, M; Li, X; Ling, L; Yao, C; Zhang, W | 1 |
| Asghar, S; Chen, Z; Jin, X; Li, H; Li, Y; Liu, J; Ping, Q; Xiao, Y; Zhu, X | 1 |
| Gong, N; Guo, HB; Guo, W; Liang, XJ; Wang, PC; Wang, YF; Wen, Y; Zhang, W | 1 |
| Gu, CX; Mo, DL; Pan, CX; Peng, Y; Qian, G; Qin, JK; Su, GF; Wei, K; Yuan, JM; Zhang, GH; Zhou, ZP | 1 |
| Jiang, H; Mao, L; Ren, X; Zhang, L; Zhang, Y | 1 |
| Bao, Y; Guo, L; Ji, F; Li, Y; Tang, Q; Wang, J | 1 |
| Hao, HJ; Liu, YX; Song, XY; Wu, XC; Zhang, HQ; Zhang, YZ | 1 |
| Ding, X; Liu, F; Liu, K; Zhang, Y | 1 |
| Bo, M; Chen, B; Chen, M; Gao, S; Li, L; Ma, Q; Yuan, K; Zhang, W; Zhu, L | 1 |
| Asghar, S; Chen, Z; Jin, X; Ping, Q; Tian, C; Xiao, Y; Yin, L; Zhu, X | 1 |
| Ji, Y; Jing, L; Shao, C; Wang, Y; Zheng, J | 1 |
| Cheng, A; Hou, Z; Jin, X; Wu, S; Xie, W; Yang, L; Yang, X | 1 |
| Guo, X; Jing, Y; Ming, Y; Xiong, X; Yang, G; Zhao, J; Zhou, S | 1 |
| Chen, Z; Jia, HR; Pan, GY; Ulrich, NW; Wu, FG; Zhu, YX | 1 |
| Li, P; Ran, H; Ren, J; Wang, Z; Xia, Y; Zhao, H; Zhou, Z; Zhu, L | 1 |
| DellaPenna, D; Jones, AD; Salim, V | 1 |
| Dong, Z; Guo, Y; Han, M; Wang, T; Wang, X; Wang, Y; Zhao, S | 1 |
| Chen, Y; Fan, Z; Hou, Z; Li, Y; Lin, J; Ma, J; Su, G; Xie, L; Zhang, H; Zhang, Y; Zhu, X | 1 |
| Hua, Q; Ma, L; Peng, H; Wang, B; Wang, M; Wei, H; Zhang, M; Zhang, X | 1 |
| Ahmad, I; Eltahan, AS; Kaleem, QM; Li, C; Liang, XJ; Mozhi, A; Tuguntaev, RG; Wang, C; Yang, R | 1 |
| Chen, X; Ding, J; Li, D; Li, J; Liu, T; Xu, W; Zhang, YS | 1 |
| Mao, S; Tian, Y; Wang, Y; Wu, H; Yu, T; Zhao, R | 1 |
| Hong, T; Li, J; Liu, W; Luo, J; Tong, L; Wang, F; Yan, L; Yang, X; Zhou, Y | 1 |
| Ao, M; Cao, Y; Hao, L; Hu, Z; Huang, J; Li, A; Li, P; Liu, J; Liu, Y; Ran, H; Wang, Z; Xu, F; Xu, J; Yao, Y | 1 |
| Dong, Z; Guo, Y; Han, M; Qiu, H; Wang, T; Wang, X; Wang, Y | 1 |
| Li, X; Sun, Y; Wang, J; Yan, L; Zeng, L | 1 |
| Fan, Z; Hou, Z; Jiang, B; Li, Y; Su, G; Tian, H; Wang, F; Ye, S; Zhang, Y; Zhu, Q | 1 |
| Ding, Y; Gao, W; Li, D; Sun, Y; Wang, T; Wang, Z; Wei, J; Yang, Y | 1 |
| Chen, H; Du, W; Li, G; Li, M; Liang, X; Yang, W; Zhang, C; Zhang, W | 1 |
| Cong, H; Liu, D; Lv, F; Shen, Y; Yu, B | 1 |
| Feng, J; Tang, X; Wu, W; Zhang, W; Zhou, T | 1 |
| Bai, X; Liu, J; Sun, Y; Wang, C; Wei, Y; Zhang, N | 1 |
| Fan, G; Jia, S; Lin, K; Shi, J; Yu, S; Yuan, J; Zhang, Y; Zhou, Q | 1 |
| Chu, X; Ding, Z; Han, J; Liu, M; Ma, Q; Sun, B; Wang, Q; Wang, Z; Zhang, H; Zhao, Y | 1 |
| Chen, J; Du, D; Liu, C; Wu, Y | 1 |
| Chen, J; He, GM; Su, XQ; Xian, GY; Yao, F; Yu, LL | 1 |
| Ding, D; Gao, F; Han, D; Jin, C; Li, J; Li, Y; Lv, C; Sun, Y; Tan, W; Wang, R; Xie, S; Yang, C | 1 |
| Li, G; Zhao, L; Zhao, M | 1 |
| Huang, S; Li, M; Nie, X; Ren, D; Wang, Y; Wu, X; Yu, X | 1 |
| Chen, P; Jian, S; Li, F; Li, H; Li, J; Liang, S; Liu, Z; Sun, X; Zeng, Y; Zhang, P; Zhang, Q | 1 |
| Chang, D; Dai, J; Gao, H; Meng, L; Pan, H; Rong, S; Zhang, Y; Zhang, Z | 1 |
| Feng, X; Jia, Z; Wang, L; Zhang, J; Zhao, C | 1 |
| Feng, M; Lai, B; Li, R; Wang, Y; Yang, Q; Zhou, X | 1 |
| Guo, Q; Liu, J; Liu, Y; Mu, G; Wang, W; Wang, Z; Zhang, J | 1 |
| Bing, T; Liu, J; Liu, X; Shangguan, D; Yi, M; Zhang, L; Zhang, N; Zhong, S | 1 |
| Fan, Z; Fu, X; Hai, J; He, S; Hou, Z; Shi, D; Yang, Y; Yin, W; Zhang, D | 1 |
| Fang, F; Gao, T; Guo, Y; Li, Y; Lv, S; Sun, S; Yang, D | 1 |
| Cong, H; Hu, H; Jing, X; Meng, Q; Shen, Y; Sun, Y; Yu, B; Zhou, L; Zhu, Y | 1 |
| Bai, J; Gao, Y; Jiang, C; Jiang, P; Liu, X; Lv, L; Ma, Z | 1 |
| Dushkin, AV; Feng, Z; Lu, Z; Su, C; Su, W; Wang, H; Zhang, Q | 1 |
| Chen, Y; Jia, L; Su, M; Wang, X; Wang, Z; Xu, F; Yang, L; Zhang, Z | 1 |
| Cui, X; Gao, Y; Meng, Q; Wang, J; Zhong, S | 1 |
| Cao, B; Deng, H; Gu, S; Li, Y; Lin, C; Shen, Z; Wei, Z | 1 |
1 review(s) available for camptothecin and 10-hydroxycamptothecin
| Article | Year |
|---|---|
Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; DNA Topoisomerases, Type I; Lactones; Nanoparticle Drug Delivery System; Water | 2022 |
3 trial(s) available for camptothecin and 10-hydroxycamptothecin
| Article | Year |
|---|---|
[Clinical study on patients with advanced gastric cancer treated with oxaliplatin combining with hydroxycamptothecine].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Stomach Neoplasms; Treatment Outcome | 2002 |
[Preliminary study of lyophilized 10-hydroxycamptothecin in advanced or recurrent malignancies].
Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Female; Humans; Male; Middle Aged; Neoplasms; Recurrence; Treatment Outcome | 2003 |
Evaluation of HCPTd1,d14-double passaged intervening chemotherapy protocol for hepatocellular carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Male; Middle Aged; Portal Vein; Treatment Outcome | 2005 |
271 other study(ies) available for camptothecin and 10-hydroxycamptothecin
| Article | Year |
|---|---|
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous | 1991 |
Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Leukemia L1210; Solubility; Structure-Activity Relationship | 1986 |
Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues.
Topics: Animals; Camptothecin; Cells, Cultured; Chemical Phenomena; Chemistry; Leukemia P388; Mice | 1980 |
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability.
Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan | 1994 |
Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin.
Topics: Antineoplastic Agents, Phytogenic; Binding Sites; Camptothecin; Half-Life; Humans; Irinotecan; Lactones; Serum Albumin; Structure-Activity Relationship | 1993 |
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Humans; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1993 |
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; Drug Screening Assays, Antitumor; Drug Stability; Electrophoresis, Agar Gel; Humans; Hydrolysis; Kinetics; Mice; Mice, Nude; Organosilicon Compounds; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Selective phenolic acylation of 10-hydroxycamptothecin using poly (ethylene glycol) carboxylic acid.
Topics: Acylation; Animals; Antineoplastic Agents; Camptothecin; Carboxylic Acids; Hydrogen Bonding; Hydroxyquinolines; Indicators and Reagents; Leukemia P388; Magnetic Resonance Spectroscopy; Neoplasms; Polyethylene Glycols; Rats; Tumor Cells, Cultured | 2003 |
7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hydrolysis; Inhibitory Concentration 50; Irinotecan; Models, Chemical; Rhodamines; Structure-Activity Relationship; Topotecan | 2009 |
Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Drug Discovery; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Conformation; Naphthyridines; Neoplasms; Quinolones; Topoisomerase I Inhibitors; Transplantation, Heterologous | 2009 |
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cell Survival; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Etoposide; Humans; Inhibitory Concentration 50; Lung Neoplasms; Naphthoquinones; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Plasmids; Pyrans; Quinones; Sesquiterpenes; Structure-Activity Relationship; Telomerase; Topoisomerase Inhibitors | 2011 |
Synthesis and biological evaluation of new homocamptothecin analogs.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA Topoisomerases, Type I; Drug Stability; Humans; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.
Topics: | 2013 |
Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors.
Topics: Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA; DNA Topoisomerases, Type I; Humans; Molecular Docking Simulation; Piperazines; Protein Conformation; Quinolones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays | 2016 |
Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Liberation; Ethylene Glycols; Humans; Irinotecan; Prodrugs | 2019 |
Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Inbred ICR; Molecular Structure; Oligosaccharides; Solubility; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2020 |
[The influence of 10-hydroxycamptothecin on the ultrastructure of ascitic hepatoma cells in mice (author's transl)].
Topics: Animals; Camptothecin; Carcinoma, Ehrlich Tumor; Liver Neoplasms, Experimental; Mice | 1979 |
Differentiation induction of human promyelocytic leukemia cells by 10-hydroxycamptothecin, a DNA topoisomerase I inhibitor.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Differentiation; DNA Topoisomerases, Type I; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; RNA, Neoplasm; Time Factors; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1991 |
[Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver].
Topics: Animals; Bone Marrow; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Liver; Mice; Micronucleus Tests; Mutagenicity Tests; Ovary | 1990 |
DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.
Topics: Amsacrine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Enzyme Inhibitors; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Mutation; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1990 |
Effects of lycobetaine on chromatin structure and activity of murine hepatoma cells.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatin; Dactinomycin; DNA Damage; DNA, Neoplasm; Harringtonines; Homoharringtonine; Indolizines; Liver Neoplasms, Experimental; Mice; Oncogenes; Time Factors; Tumor Cells, Cultured | 1990 |
Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases.
Topics: Adenosine Triphosphate; Camptothecin; Cytidine Triphosphate; DNA Damage; Guanosine Triphosphate; Humans; Molecular Weight; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1989 |
[Effects of 10-hydroxycamptothecin on chromatin protein synthesis in murine hepatoma cells].
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatin; Chromosomal Proteins, Non-Histone; Histones; Liver Neoplasms, Experimental; Mice | 1986 |
[Cytotoxicity of hydroxycamptothecin and four other antineoplastic agents on KB cells].
Topics: Alkaloids; Amaryllidaceae Alkaloids; Antineoplastic Agents, Phytogenic; Camptothecin; Colony-Forming Units Assay; Fluorouracil; Harringtonines; Homoharringtonine; Humans; Indolizines; KB Cells; Vincristine | 1987 |
[Effects of 13 compounds on the activity of globinase and amounts of free amino-acids in Plasmodium berghei].
Topics: Amino Acids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Camptothecin; Erythrocytes; Globins; Malaria; Mice; Peptide Hydrolases; Plasmodium berghei | 1987 |
[Effects of four antitumor agents on DNA circular dichroism].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cattle; Circular Dichroism; Dactinomycin; DNA; Harringtonines; Homoharringtonine; Nucleic Acid Conformation | 1987 |
[Inhibitory effect of hydroxycamptothecin on colony formation of KB cells and DNA damage].
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Chromatids; Clone Cells; Cytotoxicity, Immunologic; DNA Damage; DNA, Neoplasm; Humans; KB Cells; Sister Chromatid Exchange | 1986 |
The effect of hydroxycamptothecin in the activity of RNA and DNA polymerases prepared from murine hepatoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Nucleus; DNA Polymerase I; DNA Polymerase II; DNA Replication; DNA-Directed RNA Polymerases; In Vitro Techniques; Liver Neoplasms, Experimental; Mice; Nucleic Acid Synthesis Inhibitors | 1985 |
[Effect of 10-hydroxycamptothecin on nuclear RNA polymerase activity in hepatoma cells in mice].
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Nucleus; DNA-Directed RNA Polymerases; Liver Neoplasms, Experimental; Mice | 1984 |
[Effects of 10-hydroxycamptothecin on cAMP and cGMP levels in hepatoma and liver tissue of mice (author's transl)].
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Liver; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR | 1981 |
[Effect of 10-hydroxycamptothecin on adenylate cyclase activity in murine hepatoma cells].
Topics: Adenylyl Cyclases; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cyclic AMP; Dopamine; Liver Neoplasms, Experimental; Mice | 1982 |
[Distribution and excretion of 10-hydroxycamptothecin and its influence on immune response (author's transl)].
Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Immunity, Cellular; Immunosuppressive Agents; Mice; Tissue Distribution | 1980 |
Action of (S)-10-hydroxycamptothecin on P388 leukemia and distribution of the drug in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; DNA, Neoplasm; Flow Cytometry; Leukemia P388; Leukemia, Experimental; Mice; Tissue Distribution | 1983 |
The influence of several anticancer agents on cell proliferation, differentiation and the cell cycle of murine erythroleukemia cells.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Differentiation; Cell Division; Cell Separation; Cells, Cultured; Flow Cytometry; Harringtonines; Homoharringtonine; Indolizines; Leukemia, Erythroblastic, Acute; Mice | 1981 |
Anti-tumor effect of (S)-10-hydroxycamptothecin on mouse hepatoma BW7756 and its possible mode of action.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Flow Cytometry; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasm Transplantation | 1981 |
Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin, DNA topoisomerase I inhibitor, in murine ascites hepatoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; DNA, Neoplasm; Histones; Liver Neoplasms, Experimental; Mice; Phosphorylation; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1993 |
[Chinese material medica combined with cisplatin and lipiodol through transcatheter arterial embolization in the treatment of primary hepatoma].
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Cantharidin; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Female; Hepatic Artery; Humans; Immunotherapy, Adoptive; Iodized Oil; Liver Neoplasms; Male; Middle Aged | 1993 |
Reversed-phase high-performance liquid chromatography method for the simultaneous quantitation of the lactone and carboxylate forms of the novel natural product anticancer agent 10-hydroxycamptothecin in biological fluids and tissues.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Lactones; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 1996 |
Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Delayed-Action Preparations; Drug Stability; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Scanning; Microspheres; Molecular Weight; Pharmaceutical Vehicles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 1997 |
Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1998 |
Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Female; Humans; Proto-Oncogene Proteins c-bcl-2; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases.
Topics: Animals; Camptothecin; Carboxylic Ester Hydrolases; Esters; Fatty Acids; Humans; In Vitro Techniques; Irinotecan; Prodrugs; Rats; Swine | 1998 |
The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins.
Topics: Antineoplastic Agents; Camptothecin; Drug Carriers; Drug Interactions; Drug Stability; Electrodes; Fluorescent Dyes; Hydrogen-Ion Concentration; Lactones; Magnesium Hydroxide; Microclimate; Microspheres; Polyglactin 910; Water | 1999 |
The influence of the p53 gene on the in vitro chemosensitivity of colorectal cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Camptothecin; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Genes, p53; Humans; Male; Middle Aged; Mutation; Retrospective Studies | 1999 |
Apoptosis induction and cell cycle perturbation in human hepatoma hep G2 cells by 10-hydroxycamptothecin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cell Division; Cell Nucleus; Cell Survival; DNA Fragmentation; DNA, Neoplasm; Electrophoresis, Agar Gel; Humans; Kinetics; Liver Neoplasms, Experimental; Microscopy, Fluorescence; Tumor Cells, Cultured | 1999 |
[10-Hydroxycamptothecin induces apoptosis in human T24 urinary bladder cancer cells].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Humans; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1998 |
Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells.
Topics: alpha-Fetoproteins; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Caspase 3; Caspases; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Differentiation; Humans; Liver Neoplasms; Proliferating Cell Nuclear Antigen; Telomerase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
[The effect of hydroxycamptothecin and topotecan to SKOV3 and CAOV3 in vitro].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Division; Cystadenocarcinoma, Papillary; Cystadenocarcinoma, Serous; Female; Humans; Ovarian Neoplasms; Topotecan; Tumor Cells, Cultured | 1999 |
Antiangiogenic potential of 10-hydroxycamptothecin.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Camptothecin; Cell Division; Cell Movement; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Endothelium, Vascular; HeLa Cells; Humans; In Vitro Techniques | 2001 |
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Camptothecin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Antisense; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2001 |
Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bile; Biological Availability; Camptothecin; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Glucuronidase; Liver; Male; Mass Spectrometry; Perfusion; Rats; Rats, Wistar | 2001 |
Relationship between lactone ring forms of HCPT and their antitumor activities.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Female; Humans; Lactones; Liver Neoplasms; Mice; Sarcoma 180; Tumor Cells, Cultured | 2001 |
Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Differentiation; Humans | 2000 |
[In vitro study of radiation sensitizing effect of hydroxycamptothecin].
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; Humans; Radiation Tolerance; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2000 |
[Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Comet Assay; Flow Cytometry; Fluorescent Dyes; Hematoxylin; Humans; Staining and Labeling; Urinary Bladder Neoplasms | 1999 |
Simultaneous determination of the carboxylate and lactone forms of 10-hydroxycamptothecin in human serum by restricted-access media high-performance liquid chromatography.
Topics: Antineoplastic Agents; Calibration; Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Humans; Lactones; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |
Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Nuclear Proteins; Oligonucleotides, Antisense; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Survival Rate; Treatment Outcome; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
[Experimental studies on treatment of nasopharyngeal carcinoma with combination regimen of hydroxycamptothecin and etoposide].
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Etoposide; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
[Inhibition of hydroxycamptothecin on laryngeal squamous carcinoma cell line].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Disease Models, Animal; Flow Cytometry; Laryngeal Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; S Phase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
[Effect of the change of caspase-3 activity on the neoadjuvant chemotherapy-induced apoptosis of large-intestinal carcinoma cells].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Caspase 3; Caspases; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots.
Topics: Alkaloids; Camptotheca; Camptothecin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Genome, Plant; Phenotype; Plant Roots; Plants, Genetically Modified; Rhizobium | 2004 |
Liquid chromatography determination of 10-hydroxycamptothecin in human serum by a column-switching system containing a pre-column with restricted access media and its application to a clinical pharmacokinetic study.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reference Values; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carbon-Sulfur Lyases; Caspase 3; Caspases; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Survival; Checkpoint Kinase 1; Checkpoint Kinase 2; Cysteine; DNA Fragmentation; Drug Interactions; Enzyme Activation; Gene Expression; Humans; Irinotecan; Minichromosome Maintenance Complex Component 2; Nuclear Proteins; Organoselenium Compounds; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae Proteins; Selenocysteine | 2004 |
[Anti-tumor effects of 10-hydroxycamptothecinc-treated DC-Hepa1-6 fusion vaccines].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cancer Vaccines; Cell Fusion; Cytotoxicity, Immunologic; Dendritic Cells; Female; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Rats; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2004 |
Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins.
Topics: Animals; Antineoplastic Agents; Biological Availability; Camptothecin; Carbonates; Cell Division; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Drug Stability; Humans; Lactones; Mice; Prodrugs; Time Factors | 2004 |
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
Topics: Animals; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Intestinal Mucosa; Irinotecan; Kinetics; Liver; Models, Chemical; Nitrophenols; Protein Biosynthesis; Rabbits; Recombinant Proteins; Transfection | 2004 |
Excited-state proton transfer reactions of 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Hydrogen-Ion Concentration; Irinotecan; Kinetics; Protons; Spectrometry, Fluorescence; Structure-Activity Relationship; Titrimetry | 2004 |
[Synthesis and antitumor activities of 10-hydroxy camptothecin derivatives].
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Humans; Molecular Structure | 2004 |
[Distribution of hydroxycamptothecin after aerosol inhalation in rabbits].
Topics: Administration, Inhalation; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Camptothecin; Female; Injections, Intravenous; Lung; Male; Rabbits; Tissue Distribution | 2004 |
[Short-term effects of chemotherapy with combination of hydroxycamptothecine and oxaliplatin in the treatment of advanced digestive tract cancers].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Female; Humans; Leukopenia; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Remission Induction; Stomach Neoplasms; Treatment Outcome | 2004 |
[Antitumor effects of chemotherapeutic drugs on fresh human gastric cancer cells and their relationships to expressions of P-glycoprotein and glutathione S transferase-pi].
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Camptothecin; Cell Nucleus; Cisplatin; Cytoplasm; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Glutathione S-Transferase pi; Humans; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Tumor Cells, Cultured | 2005 |
Determination of camptothecin and 10-hydroxycamptothecin in human plasma using polymer monolithic in-tube solid phase microextraction combined with high-performance liquid chromatography.
Topics: Camptothecin; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2005 |
Synthesis and antitumor activity of A-ring modified hexacyclic analogues of camptothecin.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Humans; Irinotecan; Liver Neoplasms; Mice; Neoplasm Transplantation; Polycyclic Compounds | 2005 |
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Mice; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship | 2005 |
[Pharmacokinetic study of intraperitoneal chemotherapy with HCPT].
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Ascitic Fluid; Camptothecin; Dogs; Infusions, Parenteral; Male | 2005 |
[Synthesis and spectral characterization of 10-hydroxycamptothecin].
Topics: Camptothecin; Mass Spectrometry; Models, Molecular; Molecular Structure; Spectrum Analysis | 2005 |
Stealth PEG-PHDCA niosomes: effects of chain length of PEG on niosomes in vitro complement consumption and phagocytic uptake.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Complement System Proteins; Cyanoacrylates; Drug Carriers; Macrophages; Male; Mice; Particle Size; Phagocytosis; Polyethylene Glycols; Surface Properties | 2005 |
Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Bcl-2 siRNA induced apoptosis and increased sensitivity to 5-fluorouracil and HCPT in HepG2 cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Drug Delivery Systems; Drug Synergism; Flow Cytometry; Fluorouracil; Genes, bcl-2; Humans; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrazolium Salts; Thiazoles | 2006 |
[Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Translocation, Genetic | 2006 |
[Preparation of 10-hydroxycamptothecin semisolid lipid nanoparticles and investigation of its stability].
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Drug Carriers; Drug Stability; Freeze Drying; Lipids; Nanostructures; Particle Size; Polymers; Powders; Technology, Pharmaceutical | 2006 |
Gamma-pyranone derivatives and other constituents from Erigeron annuus.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Erigeron; Flavanones; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Pyrones; Tumor Cells, Cultured | 2006 |
[Experimental study of hydroxycamptothecine and theprubicine in the treatment of adenoid cystic carcinoma lung metastases].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Adenoid Cystic; Epirubicin; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Salivary Gland Neoplasms; Tumor Cells, Cultured | 2006 |
Stealth PEG-PHDCA niosomes: effects of chain length of PEG and particle size on niosomes surface properties, in vitro drug release, phagocytic uptake, in vivo pharmacokinetics and antitumor activity.
Topics: Algorithms; Animals; Antineoplastic Agents; Camptothecin; Cell Line; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cyanoacrylates; Drug Carriers; Drug Compounding; Drug Delivery Systems; Lactones; Macrophages; Male; Mice; Nanostructures; Particle Size; Phagocytosis; Polyethylene Glycols; Rats; Rats, Wistar; Surface Properties; Ultrasonics | 2006 |
Thermal behavior and thermal decarboxylation of 10-hydroxycamptothecin in the solid state.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Decarboxylation; Desiccation; Drug Stability; Hydrogen Bonding; Microspectrophotometry; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Thermogravimetry; Water | 2007 |
[Short-term effects of chemotherapy combined with hydroxycamptothecine and oxaliplatin in treatment of recurrent and metastatic colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Disease-Free Survival; Female; Follow-Up Studies; Humans; Leukopenia; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Remission Induction; Survival Rate | 2006 |
Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; DNA Fragmentation; Dose-Response Relationship, Drug; Glucuronidase; Glucuronides; Humans; Hybridomas; Hydrogen-Ion Concentration; Hydrolysis; Immunoconjugates; Inhibitory Concentration 50; Irinotecan; Lactones; Molecular Structure; Prodrugs; Serum Albumin; Thymidine; Time Factors; Topotecan; Tritium | 2007 |
Oxaliplatin plus hydroxycamptothecine versus oxaliplatin plus 5-fluorouracil and leucovorin in treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Treatment Outcome | 2006 |
[In vitro chemo-sensitivity MTT assay guided intraperitoneal chemotherapy for malignant ascites].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Ascites; Camptothecin; Cell Survival; Colorectal Neoplasms; Docetaxel; Female; Humans; Injections, Intraperitoneal; Kaplan-Meier Estimate; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Taxoids; Tumor Cells, Cultured | 2006 |
Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives.
Topics: Camptothecin; Chitosan; Chromatography, High Pressure Liquid; Drug Delivery Systems; Drug Stability; Hydrophobic and Hydrophilic Interactions; Micelles; Microscopy, Electron, Transmission; Molecular Structure; Particle Size; Pharmaceutical Preparations; Solubility | 2007 |
Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11.
Topics: Antineoplastic Agents, Phytogenic; Bacillaceae; Binding Sites; Camptothecin; Carboxylesterase; Crystallization; Crystallography; Cysteine; Iodine; Irinotecan; Models, Molecular; Prodrugs; Protein Conformation | 2007 |
The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Hydrogen-Ion Concentration; Irinotecan; Least-Squares Analysis; Spectrophotometry, Ultraviolet; Thermodynamics; Titrimetry | 2007 |
10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Humans; Mice; Mice, Inbred ICR; Nanoparticles; Neoplasms; Xenograft Model Antitumor Assays | 2007 |
Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Acids; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Carriers; Drug Compounding; Drug Stability; Hydrogen-Ion Concentration; Injections, Intravenous; Lactones; Light; Liver; Nanoparticles; Particle Size; Rats; Scattering, Radiation; Serum Albumin, Bovine; Sodium Hydroxide; Solubility; Surface Properties; Technology, Pharmaceutical; Tissue Distribution | 2007 |
Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Nucleus; Emulsions; Female; HeLa Cells; Humans | 2007 |
Antitumor effects of hydroxycamptothecin-loaded poly[ethylene glycol]-poly [gamma-benzyl-L-glutamate] micelles against oral squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cheek; Cricetinae; Female; Humans; Inhibitory Concentration 50; Male; Micelles; Mouth Mucosa; Mouth Neoplasms; Particle Size; Polyethylene Glycols; Polyglutamic Acid; Tongue Neoplasms | 2007 |
Changes in the protein spectrum of mitochondria isolated from hydroxycamptothecin-treated hepatoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins | 2007 |
Hydroxycamptothecin deactivation rates and binding to model membranes and HSA determined by fluorescence spectra analysis.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Irinotecan; Kinetics; Lipid Bilayers; Membranes, Artificial; Models, Biological; Protein Binding; Serum Albumin; Spectrometry, Fluorescence | 2007 |
Determination of hydroxycamptothecin affinities to albumin and membranes by steady-state fluorescence anisotropy measurements.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Fluorescence Polarization; Humans; Membranes; Molecular Structure; Serum Albumin | 2007 |
Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.
Topics: Antibodies, Neoplasm; Antineoplastic Agents; Binding, Competitive; Camptothecin; Catalysis; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Escherichia coli; Glucuronidase; Glucuronides; Humans; Kinetics; Models, Molecular; Molecular Structure; Neoplasms; Phenyl Ethers; Prodrugs; Structure-Activity Relationship | 2008 |
[Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice].
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Camptothecin; Delayed-Action Preparations; Drug Delivery Systems; Drug Stability; Female; Lipids; Lung; Mice; Mononuclear Phagocyte System; Nanoparticles; Particle Size; Phagocytosis; Polyethylene Glycols; Tissue Distribution | 2008 |
Development of efficient RNA interference system using EGF-displaying phagemid particles.
Topics: Antineoplastic Agents, Phytogenic; Bacteriophages; Camptothecin; Cell Line, Tumor; Epidermal Growth Factor; Escherichia coli; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Ligands; Plasmids; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Transduction, Genetic | 2008 |
Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Diffusion; Drug Carriers; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Rabbits; Treatment Outcome | 2008 |
Preparation and characterization of 10-hydroxycamptothecin loaded nanostructured lipid carriers.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Freeze Drying; Injections, Intravenous; Lactones; Microscopy, Electron, Transmission; Nanostructures; Particle Size; Poloxamer; Polyethylene Glycols; Solubility; Surface-Active Agents; Ultrasonics; X-Ray Diffraction | 2008 |
Novel hexacyclic camptothecin derivatives. Part 1: synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Chemical; Oxazines; Topotecan | 2008 |
PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Drug Stability; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Weight; Nanostructures; Particle Size; Polyethylene Glycols; Solubility; Stearates; Tissue Distribution | 2008 |
Combined chemotherapy of hydroxycampothecin with oxaliplatin as an adjuvant treatment for human colorectal cancer.
Topics: Adjuvants, Pharmaceutic; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Mice; Middle Aged; Neoplasm Transplantation; Organoplatinum Compounds; Oxaliplatin | 2008 |
The effect of 10-hydroxycamptothecine in preventing fibroblast proliferation and epidural scar adhesion after laminectomy in rats.
Topics: Administration, Topical; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Cicatrix; Epidural Space; Fibroblasts; Image Processing, Computer-Assisted; Immunohistochemistry; Indicators and Reagents; Laminectomy; Male; Rats; Rats, Sprague-Dawley; Tissue Adhesions | 2008 |
Inhibition of cell growth and invasion by epidermal growth factor-targeted phagemid particles carrying siRNA against focal adhesion kinase in the presence of hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Bacteriophages; Base Sequence; Camptothecin; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Combined Modality Therapy; Epidermal Growth Factor; Focal Adhesion Protein-Tyrosine Kinases; Genetic Vectors; Humans; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasms; RNA Interference; RNA, Small Interfering | 2008 |
Expeditious total syntheses of camptothecin and 10-hydroxycamptothecin.
Topics: Amines; Camptothecin; Catalysis; Kinetics | 2008 |
Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spray-drying.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Cell Line; Chromatography, High Pressure Liquid; Crystallization; Desiccation; Dogs; Drug Carriers; Drug Compounding; Lipids; Macrophages; Nanoparticles; Particle Size; Phagocytosis; Polyethylene Glycols; Powders; X-Ray Diffraction | 2008 |
Preparation, pharmacokinetics and tissue distribution of micelles made of reverse thermo-responsive polymers.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Drug Carriers; Drug Compounding; Female; Half-Life; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Micelles; Polyethylene Glycols; Propylene Glycols; Rabbits; Solubility; Spectroscopy, Fourier Transform Infrared; Temperature; Tissue Distribution | 2009 |
An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues.
Topics: Antineoplastic Agents, Phytogenic; Camptotheca; Camptothecin; Fusarium; Molecular Structure; Structure-Activity Relationship | 2009 |
[Isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide].
Topics: Camptotheca; Camptothecin; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Nylons; Seeds | 2008 |
Monolithic osmotic tablet containing solid dispersion of 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cellulose; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Delivery Systems; Excipients; Osmosis; Polyethylene Glycols; Sodium Chloride; Solubility; Tablets; Technology, Pharmaceutical; X-Ray Diffraction | 2009 |
[Efficacy of chemotherapy using 10-hydroxycamptothecin on recurrent or refractory neuroblastoma in children].
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Child; Child, Preschool; Female; Humans; Male; Neuroblastoma; Recurrence | 2009 |
Development of a chemically stable 10-hydroxycamptothecin nanosuspensions.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Chemical Precipitation; Drug Stability; Freeze Drying; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Solubility; Suspensions; X-Ray Diffraction | 2009 |
Preparation and properties of hydroxycamptothecin-loaded nanoparticles made of amphiphilic copolymer and normal polymer.
Topics: Camptothecin; Cell Line, Tumor; Drug Carriers; Humans; Micelles; Nanoparticles; Polyethylene Glycols; Polymers; Vitamin E | 2009 |
Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity.
Topics: Animals; Antineoplastic Agents; Biological Transport; Camptothecin; Cattle; Cell Line, Tumor; Drug Carriers; Esters; Ethylene Glycol; Humans; Hydrophobic and Hydrophilic Interactions; Liver Neoplasms; Mice; Nanotubes, Carbon; Solubility; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Topoisomerase I Inhibitors; Water | 2009 |
Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Base Sequence; Camptothecin; DNA, Ribosomal; Fusarium; Magnoliopsida; Mycorrhizae; Trees | 2010 |
Modified hydrolysis kinetics of the active lactone moiety of 10-hydroxycamptothecin by liposomal encapsulation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Drug Stability; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Liposomes; Rabbits; Time Factors | 2010 |
10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata.
Topics: Camptotheca; Camptothecin; Cluster Analysis; Culture Media; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal Spacer; Genes, rRNA; Molecular Sequence Data; Phylogeny; RNA, Fungal; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Xylariales | 2010 |
Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for the treatment of hepatoma in clinical application.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Phospholipids; Tissue Distribution | 2010 |
Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-beta-cyclodextrin inoculations.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; Apoptosis; beta-Cyclodextrins; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Stability; Female; Humans; Lactates; Nanofibers; Nanotechnology; Polyethylene Glycols; Surface Properties | 2010 |
Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Mice; Microscopy, Electron, Scanning; Neoplasm Recurrence, Local; Polyesters; Surface Properties; Tissue Scaffolds | 2010 |
Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Camptothecin; Carbodiimides; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Micelles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Stearic Acids; Technology, Pharmaceutical | 2010 |
[Prediction of absorption of 10-hydroxycamptothecin in small intestines of rats with its partition coefficients in phases of liposomes and water].
Topics: Animals; Camptothecin; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Liposomes; Rats; Water | 2010 |
Recombinant high density lipoprotein reconstituted with apolipoprotein AI cysteine mutants as delivery vehicles for 10-hydroxycamptothecin.
Topics: Animals; Apolipoprotein A-I; Camptothecin; Cysteine; Drug Carriers; Female; HCT116 Cells; Humans; Lipoproteins, HDL; Mice; Mice, Inbred BALB C; Nanoparticles; Pharmaceutical Vehicles; Recombinant Fusion Proteins; Tissue Distribution | 2010 |
Experimental evaluation of inhibitory effect of 10-hydroxycamptothecin on hypoxia-inducible factor-1α expression and angiogenesis in liver tumors after transcatheter arterial embolization.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Catheterization; Embolization, Therapeutic; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Neovascularization, Pathologic; Rabbits; Treatment Outcome; Vascular Endothelial Growth Factor A | 2010 |
Anticancer properties of 10-hydroxycamptothecin in a murine melanoma pulmonary metastasis model in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL | 2011 |
Novel nanogels as drug delivery systems for poorly soluble anticancer drugs.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Drug Screening Assays, Antitumor; Gels; Humans; Micelles; Molecular Structure; Nanostructures; Paclitaxel; Solubility | 2011 |
Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; MicroRNAs; RNA, Messenger; Stomach Neoplasms | 2011 |
Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response.
Topics: Absorption; Antineoplastic Agents, Phytogenic; Camptothecin; Drug Carriers; Ferrosoferric Oxide; Hydrogen-Ion Concentration; Metal Nanoparticles; Particle Size; Polystyrenes; Spectroscopy, Fourier Transform Infrared | 2011 |
Application of liposome-encapsulated hydroxycamptothecin in the prevention of epidural scar formation in New Zealand white rabbits.
Topics: Animals; Camptothecin; Cicatrix; Disease Models, Animal; Drug Carriers; Epidural Space; Intervertebral Disc; Intervertebral Disc Displacement; Laminectomy; Liposomes; Lumbar Vertebrae; Rabbits; Tissue Adhesions; Wound Healing | 2011 |
Hydroxycamptothecin-loaded Fe3O4 nanoparticles induce human lung cancer cell apoptosis through caspase-8 pathway activation and disrupt tight junctions.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cadherins; Camptothecin; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Survival; Claudins; Drug Delivery Systems; Ferrous Compounds; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Potentials; Membrane Proteins; Nanoparticles; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Tight Junctions; X-Ray Diffraction; Zonula Occludens-1 Protein | 2011 |
Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Camptotheca; Camptothecin; Cell Culture Techniques; Culture Media; Drugs, Chinese Herbal | 2010 |
Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Folic Acid; Humans; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanomedicine; Nanoparticles; Particle Size; Serum Albumin; X-Ray Diffraction | 2011 |
Iron/dextran sulfate multilayered microcapsules for controlled release of 10-hydroxycamptothecin.
Topics: Animals; Antineoplastic Agents; Camptothecin; Capsules; Delayed-Action Preparations; Dextran Sulfate; Iron; Male; Mice; Surface Properties | 2011 |
A practical strategy for constructing nanodrugs using carbon nanotubes as carriers.
Topics: Amides; Amines; Animals; Camptothecin; Cell Line, Tumor; Drug Carriers; Ethylene Glycol; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Liver Neoplasms; Mice; Nanotubes, Carbon; Oxidation-Reduction; Rats; Succinic Acid; Technetium Tc 99m Pentetate; Tomography, Emission-Computed, Single-Photon | 2011 |
Preparation and physicochemical properties of 10-hydroxycamptothecin (HCPT) nanoparticles by supercritical antisolvent (SAS) process.
Topics: Calorimetry, Differential Scanning; Camptothecin; Carbon Dioxide; Chromatography, Supercritical Fluid; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Solvents; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2011 |
Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Drug Delivery Systems; Excipients; Fatty Acids; Freeze Drying; Humans; Microspheres; Neoplasms; Particle Size; Polymethacrylic Acids; Solubility; Ultrasonics | 2011 |
Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine.
Topics: Animals; Antineoplastic Agents; Biological Transport; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemical Phenomena; Delayed-Action Preparations; Drug Carriers; Half-Life; Humans; Ligands; Lipids; Liver Neoplasms; Male; Nanostructures; Neoplasm Proteins; Octreotide; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin | 2011 |
Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Chemistry, Pharmaceutical; Half-Life; Injections, Intravenous; Nanoparticles; Rats; Rats, Wistar; Suspensions | 2011 |
Hepatocellular necrosis, apoptosis, and proliferation after transcatheter arterial embolization or chemoembolization in a standardized rabbit model.
Topics: Alanine Transaminase; Angiography, Digital Subtraction; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Aspartate Aminotransferases; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Chemoembolization, Therapeutic; Embolization, Therapeutic; Hepatic Artery; In Situ Nick-End Labeling; Iodized Oil; Ki-67 Antigen; Liver Function Tests; Liver Neoplasms, Experimental; Liver Regeneration; Magnetic Resonance Imaging; Necrosis; Polyvinyl Alcohol; Rabbits; Time Factors; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha | 2011 |
[Study on pharmacokinetics of HCPT nanosuspensions with ability of inhibiting P-gp in rats after oral administration].
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calibration; Camptothecin; Linear Models; Male; Nanostructures; Rats; Rats, Wistar; Suspensions | 2011 |
Interaction of human serum albumin with 10-hydroxycamptothecin: spectroscopic and molecular modeling studies.
Topics: Camptothecin; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Protein Binding; Protein Structure, Secondary; Serum Albumin; Spectrometry, Fluorescence; Temperature | 2012 |
Functionalized hydrophobic poly(glycerol-co-ε-caprolactone) depots for controlled drug release.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Lung Neoplasms; Magnetic Resonance Spectroscopy; Particle Size; Polyesters; Surface Properties | 2012 |
[Lidamycin inhibits the proliferation of HERG K+ channel highly expressing cancer cells and shows synergy with anticancer drugs].
Topics: Aminoglycosides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; Enediynes; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluorouracil; HT29 Cells; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays | 2011 |
Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Carriers; Emulsions; Humans; Lactates; Mice; Neoplasm Transplantation; Neoplasms; Polyethylene Glycols; Tumor Burden | 2012 |
A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Half-Life; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Lactones; Limit of Detection; Liquid-Liquid Extraction; Liver; Male; Mice; Reproducibility of Results; Solubility; Spectrometry, Fluorescence; Tissue Distribution | 2012 |
Preparation and in vitro evaluation of an ultrasound-triggered drug delivery system: 10-hydroxycamptothecin loaded PLA microbubbles.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Chromatography, High Pressure Liquid; Cytotoxicity Tests, Immunologic; Drug Delivery Systems; Flow Cytometry; In Vitro Techniques; Microbubbles; Microscopy, Confocal; Microscopy, Electron; Transducers; Ultrasonics; X-Ray Diffraction | 2012 |
Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspase 8; Caspase 9; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Microscopy, Electron, Transmission; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tenon Capsule | 2012 |
Carrier-free, functionalized drug nanoparticles for targeted drug delivery.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Maleic Anhydrides; Nanoparticles; Neoplasms; Polyethylene Glycols | 2012 |
Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Male; Mice; Microbubbles; Neoplasms; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Sonication; Tumor Burden | 2012 |
Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Humans; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2012 |
Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptotheca; Camptothecin; Cell Line, Tumor; Leukemia L1210; Phytotherapy; Plant Extracts; Treatment Outcome | 2012 |
Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzaldehydes; Camptothecin; Carcinoma, Hepatocellular; Electrochemistry; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Lactates; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Molecular Weight; Polyethylene Glycols; Survival Rate; Tumor Microenvironment | 2012 |
Enhanced in vitro antitumor efficacy and strong anti-cell-migration activity of a hydroxycamptothecin-encapsulated magnetic nanovehicle.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Movement; Drug Carriers; Ferrosoferric Oxide; HeLa Cells; Hep G2 Cells; Humans; Magnetic Fields; Magnetite Nanoparticles; Micelles | 2012 |
PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studies.
Topics: Camptothecin; Cell Survival; Chitosan; Drug Carriers; Ferric Compounds; Hep G2 Cells; Humans; Nanoparticles; Polyethylene Glycols | 2013 |
[Fluorimetric analysis of camptothecin in Chinese herbal medicine common Camptotheca fruit].
Topics: Antineoplastic Agents, Phytogenic; Camptotheca; Camptothecin; Chromatography, Thin Layer; Fruit; Plants, Medicinal; Quality Control; Reproducibility of Results; Spectrometry, Fluorescence | 2012 |
Bioluminescence imaging of DNA synthetic phase of cell cycle in living animals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Cyclin A2; DNA; Genes, Reporter; HeLa Cells; Humans; Luminescent Measurements; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy; Recombinant Fusion Proteins; RNA, Small Interfering; S Phase; Whole Body Imaging | 2013 |
Enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified N-succinyl-N'-octyl chitosan micelles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Mice; Mice, Nude; Micelles; Neoplasms; Rats | 2013 |
Co-delivery of 10-hydroxycamptothecin with doxorubicin conjugated prodrugs for enhanced anticancer efficacy.
Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Survival; Dendrimers; Doxorubicin; Drug Delivery Systems; Endocytosis; Flow Cytometry; Hep G2 Cells; Humans; Intracellular Space; Magnetic Resonance Spectroscopy; MCF-7 Cells; Microscopy, Confocal; Nanoparticles; Polyethylene Glycols; Prodrugs | 2013 |
Comparison of the effects of mitomycin C and 10-hydroxycamptothecin on an experimental intraarticular adhesion model in rabbits.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cartilage, Articular; Cell Adhesion; Cell Count; Fibroblasts; Hydroxyproline; Knee Joint; Male; Mitomycin; Protective Agents; Rabbits | 2013 |
Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticles.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Survival; Humans; Lipids; Materials Testing; MCF-7 Cells; Molecular Targeted Therapy; Nanocapsules; Oligopeptides; Polymers | 2013 |
Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cattle; Cell Line, Tumor; Drug Carriers; Glycyrrhizic Acid; Hemolysis; Humans; Liver Neoplasms; Nanoparticles; Particle Size; Rabbits; Serum Albumin, Bovine | 2013 |
Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption.
Topics: Acrylic Resins; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colon; Delayed-Action Preparations; Drug Delivery Systems; Fatty Acids; Hydrogen-Ion Concentration; Microspheres; Rats | 2013 |
Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Proliferation; Colonic Neoplasms; Female; Humans; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survivin; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2013 |
Characterization and quantification of 10-hydroxycamptothecine in Camptotheca acuminate and its medicinal preparation by liquid chromatography-ion trap mass spectrometry.
Topics: Camptotheca; Camptothecin; Chromatography, Liquid; Fruit; Ions; Mass Spectrometry; Plant Extracts | 2013 |
Carrier-free functionalized multidrug nanorods for synergistic cancer therapy.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Carriers; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; KB Cells; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Nanotubes; Neoplasms; Paclitaxel | 2013 |
Development and application of a UPLC-MS/MS method for the pharmacokinetic study of 10-hydroxy camptothecin and hydroxyethyl starch conjugate in rats.
Topics: Animals; Area Under Curve; Biological Availability; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Hydroxyethyl Starch Derivatives; Magnetic Resonance Spectroscopy; Male; Quality Control; Rats; Rats, Wistar; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Smart nanorods for highly effective cancer theranostic applications.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds, Heterocyclic; Camptothecin; Cell Line, Tumor; Disulfides; Drug Carriers; Half-Life; HeLa Cells; Humans; Magnetic Resonance Imaging; Mice, Inbred BALB C; Nanotubes; Neoplasms; Phototherapy; Polyethylene Glycols; Polymers; Radiography; Tissue Distribution | 2014 |
[Efficacy of treatment with siRNA targeting Bcl-2 in combination with HCPT against transplanted H₂₂ hepatoma in mice].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Cycle; Drug Synergism; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-bcl-2; Random Allocation; RNA, Messenger; RNA, Small Interfering; Transfection; Tumor Burden | 2013 |
Investigation of dual-sensitive nanogels based on chitosan and N-isopropylacrylamide and its intelligent drug delivery of 10-hydroxycamptothecine.
Topics: Acrylamides; Acrylic Resins; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Chitosan; Drug Delivery Systems; Drug Liberation; Dynamic Light Scattering; Gels; Humans; Hydrogen-Ion Concentration; Molecular Weight; Technology, Pharmaceutical; Temperature | 2015 |
A novel multifunctional poly(amidoamine) dendrimeric delivery system with superior encapsulation capacity for targeted delivery of the chemotherapy drug 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Survival; Chemistry, Pharmaceutical; Dendrimers; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Endocytosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Integrin alphaVbeta3; Kinetics; Male; MCF-7 Cells; Peptides, Cyclic; Polyamines; Prostatic Neoplasms; Solubility; Surface Properties; Technology, Pharmaceutical | 2014 |
Self-assembling peptide of D-amino acids boosts selectivity and antitumor efficacy of 10-hydroxycamptothecin.
Topics: Amino Acids; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Drug Delivery Systems; Humans; Mice; Mice, Inbred BALB C; Neoplasms; Peptides | 2014 |
Functional core/shell drug nanoparticles for highly effective synergistic cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Gold; Laser Therapy; Materials Testing; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Tissue Distribution; Xenograft Model Antitumor Assays | 2014 |
Role of Bmbuffy in hydroxycamptothecine-induced apoptosis in BmN-SWU1 cells of the silkworm, Bombyx mori.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bombyx; Camptothecin; Caspase 3; Cell Line; Cytochromes c; Endoplasmic Reticulum; Insect Proteins; Mitochondrial Membranes; Permeability; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2014 |
The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Femur; Hydroxyproline; Male; Patellofemoral Joint; Rabbits; Random Allocation; Tissue Adhesions | 2014 |
A simple HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat liver tissue.
Topics: Animals; Calibration; Camptothecin; Chromatography, High Pressure Liquid; Fluorescence; Limit of Detection; Liver; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Tissue Distribution | 2015 |
Biocleavable graphene oxide based-nanohybrids synthesized via ATRP for gene/drug delivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; Chlorocebus aethiops; COS Cells; Drug Carriers; Free Radicals; Genetic Vectors; Graphite; Hep G2 Cells; Humans; Methacrylates; Microscopy, Atomic Force; Nanostructures; Oxides; Polymerization; Transfection | 2014 |
Hydroxyethyl starch conjugates for improving the stability, pharmacokinetic behavior and antitumor activity of 10-hydroxy camptothecin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Drug Stability; Humans; Hydroxyethyl Starch Derivatives; Male; Mice, Nude; Molecular Structure; Rats, Wistar; Xenograft Model Antitumor Assays | 2014 |
Integrin α(V)β(3)-targeted magnetic nanohybrids with enhanced antitumor efficacy, cell cycle arrest ability, and encouraging anti-cell-migration activity.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Liberation; HEK293 Cells; Humans; Integrin alphaVbeta3; Lactic Acid; Magnetite Nanoparticles; Maleimides; Micelles; Microscopy, Electron, Transmission; Peptides; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proton Magnetic Resonance Spectroscopy; Wound Healing | 2014 |
[Preparation and in vitro embolic efficiency evaluation of hydroxycamptothecine-loaded liquid embolic agent].
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Camptothecin; Delayed-Action Preparations; Fatty Alcohols; Liquid Crystals; Scattering, Small Angle; Water; X-Ray Diffraction | 2014 |
[Studies on the effects of cucurbit (n = 7) uril on the physicohemical properties and anticancer activity of 10-hydroxycamptothecin].
Topics: Antineoplastic Agents; Bridged-Ring Compounds; Camptothecin; Humans; Imidazoles; K562 Cells; Solubility; Spectrometry, Fluorescence | 2014 |
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor.
Topics: Antineoplastic Agents; Camptothecin; Cycloaddition Reaction; Hep G2 Cells; Humans; KB Cells; Molecular Docking Simulation; Quinones; Topotecan | 2015 |
RPL13A as a reference gene for normalizing mRNA transcription of ovarian cancer cells with paclitaxel and 10-hydroxycamptothecin treatments.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Computational Biology; Female; Gene Expression Profiling; Humans; Ovarian Neoplasms; Paclitaxel; Ribosomal Proteins; RNA Stability; RNA, Messenger; Transcription, Genetic | 2015 |
The aspect ratio effect of drug nanocrystals on cellular internalization efficiency, uptake mechanisms, and in vitro and in vivo anticancer efficiencies.
Topics: Animals; Antineoplastic Agents; Camptothecin; Drug Carriers; Drug Screening Assays, Antitumor; Female; Humans; Liver; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Nanomedicine; Nanoparticles; Neoplasm Transplantation; Neoplasms; Polyethylene Glycols | 2015 |
The Effect of Hydroxycamptothecin on Wound Healing Following Reduction of the Knee Intra-Articular Adhesion in Rabbits.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arthroplasty, Replacement, Knee; Camptothecin; Fibroblasts; Knee Joint; Male; Postoperative Complications; Rabbits; Tissue Adhesions; Vascular Endothelial Growth Factor A; Wound Healing | 2015 |
Simultaneous determination of camptothecin and 10-hydroxycamptothecine in the Camptotheca acuminate, its medicinal preparation and in rat plasma by liquid chromatography with fluorescence detection.
Topics: Administration, Oral; Animals; Camptotheca; Camptothecin; Chromatography, Liquid; Drugs, Chinese Herbal; Fluorescence; Limit of Detection; Plants, Medicinal; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2015 |
Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Liberation; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Male; Mice; Mice, Nude; Nanoparticles; Particle Size | 2015 |
Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Hep G2 Cells; HT29 Cells; Humans; Neoplasms; Polyethylene Glycols; Solubility | 2015 |
Spatial distribution and antitumor activities after intratumoral injection of fragmented fibers with loaded hydroxycamptothecin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Delayed-Action Preparations; Diffusion; Female; Hep G2 Cells; Humans; Injections, Intralesional; Mice; Nanocapsules; Nanofibers; Neoplasms, Experimental; Particle Size; Survival Rate; Tissue Distribution; Treatment Outcome | 2015 |
A novel drug-polyethylene glycol liquid compound method to prepare 10-hydroxycamptothecin loaded human serum albumin nanoparticle.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Carriers; Drug Compounding; Hep G2 Cells; Humans; MCF-7 Cells; Nanoparticles; Polyethylene Glycols; Polymers; Serum Albumin | 2015 |
Phytantriol based liquid crystal provide sustained release of anticancer drug as a novel embolic agent.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Embolization, Therapeutic; Fatty Alcohols; Hep G2 Cells; Humans; Liquid Crystals; Mice; NIH 3T3 Cells; Solvents; Time Factors | 2016 |
Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance.
Topics: Antineoplastic Agents; Camptothecin; Cell Count; Cell Death; Cell Line, Tumor; Colony-Forming Units Assay; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Molecular Dynamics Simulation; Nanoparticles; Nanospheres; Nanotubes; Spectrometry, Fluorescence | 2015 |
High Drug Payload 10-Hydroxycamptothecin Nanosuspensions Stabilized by Cholesterol-PEG: In Vitro and In Vivo Investigation.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Camptothecin; Cholesterol; Crystallization; Drug Delivery Systems; Hep G2 Cells; Humans; Male; Mice; Mice, Inbred ICR; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanomedicine; Nanoparticles; Neoplasm Transplantation; Polyethylene Glycols; Pressure; Rats; Rats, Sprague-Dawley; X-Ray Diffraction | 2015 |
Nanomicelle Based Peroral Delivery System for Enhanced Absorption and Sustained Release of 10-Hydrocamptothecin.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Gastrointestinal Absorption; Humans; Male; Mice; Mice, Nude; Mice, SCID; Micelles; Rats; Rats, Wistar; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Resistance, Multiple; Glucans; Hep G2 Cells; Humans; Lipids; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanostructures; Particle Size; Soybean Oil; Xylans | 2016 |
Shape regulated anticancer activities and systematic toxicities of drug nanocrystals in vivo.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; Crystallization; Drug Compounding; Female; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms, Experimental; Particle Size; Treatment Outcome | 2016 |
Liposomes Encapsulating 10-Hydroxycamptothecin-Cyclodextrin Complexes and Their In Vitro Anti-Tumor Activities.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Camptothecin; Cell Line, Tumor; Hep G2 Cells; Humans; Liposomes | 2015 |
Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Nucleus; Cell Survival; Delayed-Action Preparations; Drug Synergism; Endocytosis; Fluorescence; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanospheres; Nanotubes; Particle Size; Rats, Sprague-Dawley | 2015 |
A novel 10-hydroxycamptothecin-glucoside from the fruit of Camptotheca acuminata.
Topics: Camptotheca; Camptothecin; Carbohydrates; Carbolines; Fruit; Furans; Glucosides; Glycosides; Hydrolysis; Lignans; Magnetic Resonance Spectroscopy; Quercetin; Spectrometry, Mass, Electrospray Ionization | 2016 |
10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53, cytochrome c and caspase 3 pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Cell Proliferation; Cytochromes c; Humans; Neuroblastoma; Tumor Suppressor Protein p53 | 2016 |
Hyaluronic Acid Modified Hollow Prussian Blue Nanoparticles Loading 10-hydroxycamptothecin for Targeting Thermochemotherapy of Cancer.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Drug Carriers; Drug Therapy; Ferrocyanides; HeLa Cells; Humans; Hyperthermia, Induced; Nanoparticles; Neoplasms | 2016 |
In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells.
Topics: Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Humans; Nanoparticles; Neoplasms; Particle Size; Solubility; Tissue Distribution | 2016 |
[Effect of 10-hydroxycamptotbecine on the expression of VEGF in rheumatoid arthritis synovial fibroblasts].
Topics: Arthritis, Rheumatoid; Camptothecin; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Methotrexate; Synovial Membrane; Vascular Endothelial Growth Factor A | 2015 |
Effects of 10-hydroxycamptothecin on intrinsic mitochondrial pathway in silkworm BmN-SWU1 cells.
Topics: Animals; Apoptosis; Bombyx; Camptothecin; Cell Line; Female; Mitochondria; Ovary | 2016 |
Effects of nanoparticle size on antitumor activity of 10-hydroxycamptothecin-conjugated gold nanoparticles: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Carriers; Female; Gold; Humans; Metal Nanoparticles; Mice; Particle Size | 2016 |
A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Liberation; Endocytosis; Female; Freeze Drying; Humans; Mice, Inbred BALB C; Nanoparticles; Nanotechnology; Organic Chemicals; Particle Size; Rats, Sprague-Dawley; Solubility; Solvents; Tissue Distribution; X-Ray Diffraction | 2016 |
Achieving High Drug Loading and Sustained Release of Hydrophobic Drugs in Hydrogels through In Situ Crystallization.
Topics: Camptothecin; Crystallization; Delayed-Action Preparations; Drug Delivery Systems; Humans; Hydrogels; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Neoplasms; Polyethylene Glycols | 2017 |
Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo.
Topics: Animals; Antineoplastic Agents; Biological Transport; Camptothecin; Dendrimers; Drug Carriers; Drug Liberation; Drug Stability; Fluorescent Dyes; Hep G2 Cells; Humans; Male; Mice; Nanotubes; Polyethylene Glycols; Solvents; Tissue Distribution | 2017 |
Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma.
Topics: Adhesiveness; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Carriers; Drug Liberation; Gels; Humans; Male; Mice, Inbred BALB C; Mucous Membrane; Nanostructures; Peptides; Tissue Distribution; Urinary Bladder Neoplasms | 2017 |
A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Camptothecin; Cell Survival; Chitosan; Delayed-Action Preparations; Drug Carriers; Drug Combinations; Drug Compounding; Drug Stability; Drug Synergism; Female; Green Chemistry Technology; HeLa Cells; Humans; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Nanoparticles; Solubility; Technology, Pharmaceutical; Tissue Distribution; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery.
Topics: Animals; Antineoplastic Agents; Arginine; Camptothecin; Chitosan; Drug Carriers; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Male; Mice; Nanostructures; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays | 2017 |
Supramolecular "Trojan Horse" for Nuclear Delivery of Dual Anticancer Drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Macromolecular Substances; Mice; Molecular Structure; Nanomedicine; Neoplasms | 2017 |
"Bottom-up" Construction of Multi-Polyprodrug-Arm Hyperbranched Amphiphiles for Cancer Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Proliferation; Drug Carriers; Drug Delivery Systems; Female; Humans; Mice; Micelles; Polymers; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Dual 7-ethyl-10-hydroxycamptothecin conjugated phospholipid prodrug assembled liposomes with in vitro anticancer effects.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Humans; Liposomes; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Phospholipids; Prodrugs; Solubility; Succinic Acid | 2017 |
Enhanced oral bioavailability of 10-hydroxycamptothecin through the use of poly (n-butyl cyanoacrylate) nanospheres.
Topics: Animals; Biological Availability; Camptothecin; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Emulsions; Enbucrilate; Nanoparticles; Nanospheres; Particle Size; Poloxamer; Rats | 2017 |
Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.
Topics: A549 Cells; Animals; Camptothecin; Cell Line, Tumor; Chlorophyllides; Female; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanotubes; Neoplasms, Experimental; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays | 2017 |
Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Phthalazines; Quinazolinones; S Phase Cell Cycle Checkpoints; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2017 |
Mitochondria response to camptothecin and hydroxycamptothecine-induced apoptosis in Spodoptera exigua cells.
Topics: Animals; Apoptosis; Biological Control Agents; Calcium; Camptothecin; Cell Line; Fat Body; Membrane Potential, Mitochondrial; Mitochondria; Spodoptera | 2017 |
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Synergism; Female; Humans; Membrane Potential, Mitochondrial; Mice, Nude; Neoplasms; Quercetin; Topoisomerase I Inhibitors; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
[Comparison of bioavailability of two kinds of solid dispersion from 10-hydroxycamptothecin in SD rats in vivo].
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Camptothecin; Drug Carriers; Drugs, Chinese Herbal; Male; Phospholipids; Rats; Rats, Sprague-Dawley | 2016 |
De novo transcriptome assembly and characterization of the 10-hydroxycamptothecin-producing Xylaria sp. M71 following salicylic acid treatment.
Topics: Biosynthetic Pathways; Camptothecin; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Molecular Sequence Annotation; Salicylic Acid; Sequence Analysis, DNA; Transcriptome; Xylariales | 2017 |
Preclinical Evaluation and Monitoring of the Therapeutic Response of a Dual Targeted Hyaluronic Acid Nanodrug.
Topics: Animals; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Drug Carriers; Heterografts; Humans; Hyaluronic Acid; Mice; Nanoparticles | 2017 |
In vitro and in vivo evaluation of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate) nanoparticles prepared by miniemulsion polymerization.
Topics: Animals; Caco-2 Cells; Camptothecin; Drug Carriers; Drug Compounding; Drug Liberation; Emulsions; Enbucrilate; Endocytosis; Humans; Male; Nanoparticles; Particle Size; Phospholipids; Polyethylene Glycols; Polymerization; Polysorbates; Rats; Rats, Sprague-Dawley | 2018 |
Pharmacokinetics and tissue distribution study of 10-methoxycamptothecin in rats following intragastric administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Camptothecin; Chromatography, High Pressure Liquid; Liquid-Liquid Extraction; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Time Factors; Tissue Distribution | 2018 |
Dual-drug loaded nanoneedles with targeting property for efficient cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Survival; Drug Carriers; Drug Liberation; Drug Synergism; HeLa Cells; Humans; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles; Neoplasms; Polyethylene Glycols; Polyglactin 910; Tissue Distribution; Transplantation, Heterologous | 2017 |
A Multifunctional Micellar Nanoplatform with pH-Triggered Cell Penetration and Nuclear Targeting for Effective Cancer Therapy and Inhibition to Lung Metastasis.
Topics: A549 Cells; Animals; Camptothecin; Delayed-Action Preparations; Drug Carriers; Female; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Neoplasm Metastasis | 2018 |
Development of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials.
Topics: Camptothecin; Cell Line, Tumor; Cell Nucleus; Cell Survival; Docetaxel; Drug Delivery Systems; Fluorescent Dyes; Humans; Light; Nanoparticles; Organosilicon Compounds; Particle Size; Polyamines; Polyethylene Glycols; Rose Bengal; Taxoids | 2018 |
Peptide-Functionalized Phase-Transformation Nanoparticles for Low Intensity Focused Ultrasound-Assisted Tumor Imaging and Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Mice, Nude; Molecular Imaging; Nanoparticles; Optical Imaging; Peptides; Phase Transition; Ultrasonography | 2018 |
Camptotheca acuminata 10-hydroxycamptothecin O-methyltransferase: an alkaloid biosynthetic enzyme co-opted from flavonoid metabolism.
Topics: Alkaloids; Camptotheca; Camptothecin; Chromatography, High Pressure Liquid; Flavonoids; Metabolic Networks and Pathways; Methyltransferases; Phylogeny; Plant Proteins; Transcriptome | 2018 |
Amphiphilic Hybrid Dendritic-Linear Molecules as Nanocarriers for Shape-Dependent Antitumor Drug Delivery.
Topics: Amines; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Nanospheres; Nanotubes; Neoplasms; Particle Size; Polyethylene Glycols; Rats; Surface-Active Agents; Treatment Outcome | 2018 |
Integration of phospholipid-hyaluronic acid-methotrexate nanocarrier assembly and amphiphilic drug-drug conjugate for synergistic targeted delivery and combinational tumor therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Drug Carriers; Drug Compounding; Drug Synergism; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hyaluronic Acid; MCF-7 Cells; Methotrexate; Mice; Mice, Nude; Nanoparticles; Phosphatidylethanolamines; Survival Analysis; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Facile Fabrication of 10-Hydroxycamptothecin-Backboned Amphiphilic Polyprodrug with Precisely Tailored Drug Loading Content for Controlled Release.
Topics: Antineoplastic Agents; Camptothecin; Cycloaddition Reaction; Delayed-Action Preparations; Drug Liberation; Humans; Hydrophobic and Hydrophilic Interactions; Micelles; Molecular Weight; Polyethylene Glycols; Polymers; Prodrugs; Surface-Active Agents | 2018 |
Nrp-1 receptor targeting peptide-functionalized TPGS micellar nanosystems to deliver 10-hydroxycampothecin for enhanced cancer chemotherapy.
Topics: A549 Cells; Apoptosis; Camptothecin; Cell Nucleus; DNA Topoisomerases, Type I; Drug Carriers; Drug Synergism; Hep G2 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Micelles; Mitochondria; Nanoparticles; Neoplasms; Neuropilin-1; Peptides; Polymers; Reactive Oxygen Species; Topoisomerase I Inhibitors; Vitamin E | 2018 |
Locally Deployable Nanofiber Patch for Sequential Drug Delivery in Treatment of Primary and Advanced Orthotopic Hepatomas.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Drug Implants; Female; Liver Neoplasms; Mice, Inbred BALB C; Nanofibers; Polyphenols | 2018 |
Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri.
Topics: Acetic Acid; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Delivery Systems; Drugs, Chinese Herbal; Glutathione Transferase; Liver; Medicine, Chinese Traditional; Micelles; Rats, Sprague-Dawley | 2018 |
Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Astragalus Plant; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression; Humans; Lung Neoplasms; Mitochondria; Polysaccharides; Protein Serine-Threonine Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Delivery Systems; Fluorocarbons; Folic Acid; Humans; Magnetite Nanoparticles; Mice; Mice, Nude; Molecular Imaging; Nanostructures; Theranostic Nanomedicine; Tissue Distribution; Ultrasonic Waves | 2018 |
Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Stability; Drug Storage; Ethylene Glycol; Humans; Injections, Intravenous; Mice; Mice, Inbred BALB C; Molecular Conformation; Nanoparticles; Neoplasms; Particle Size; Rats; Tissue Distribution | 2019 |
10‑Hydroxycamptothecin induces apoptosis in human fibroblasts by regulating miRNA‑23b‑3p expression.
Topics: Adult; Aged; Apoptosis; Camptothecin; Cicatrix, Hypertrophic; Female; Fibroblasts; Gene Expression Regulation; Humans; Male; MicroRNAs; Middle Aged | 2019 |
Light/pH-Triggered Biomimetic Red Blood Cell Membranes Camouflaged Small Molecular Drug Assemblies for Imaging-Guided Combinational Chemo-Photothermal Therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomimetics; Camptothecin; Cell Membrane; Erythrocytes; HeLa Cells; Humans; Hydrogen-Ion Concentration; Indocyanine Green; Infrared Rays; Male; Mice; Mice, Nude; Nanoparticles; Neoplasms; Phototherapy; Rats; Rats, Sprague-Dawley | 2019 |
Synergistic antitumour effects of triptolide plus 10-hydroxycamptothecin onbladder cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diterpenes; Drug Synergism; Epoxy Compounds; Mice, Inbred BALB C; Mice, Nude; Phenanthrenes; Reactive Oxygen Species; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Lewis Lung; Chromatography, Liquid; Cytokines; Disease Models, Animal; Drug Monitoring; Drugs, Chinese Herbal; Glycyrrhiza; Lung Neoplasms; Male; Mice; Plant Roots; Rhizome; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution; Xenograft Model Antitumor Assays | 2019 |
Synthesis, self-assembly and drug release behaviors of a bottlebrush polymer-HCPT prodrug for tumor chemotherapy.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Drug Liberation; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Micelles; Molecular Structure; Particle Size; Polymers; Prodrugs; Surface Properties | 2019 |
Preparation and
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Camptothecin; Drug Carriers; Female; Glycyrrhetinic Acid; Liposomes; Mice; Particle Size; Rats; Tissue Distribution | 2019 |
The biosynthesis of camptothecin derivatives by
Topics: Camptotheca; Camptothecin; Hydrogen-Ion Concentration; Plant Roots; Seedlings | 2021 |
Specific Modification with TPGS and Drug Loading of Cyclodextrin Polyrotaxanes and the Enhanced Antitumor Activity Study in Vitro and in Vivo.
Topics: Animals; Anticarcinogenic Agents; Camptothecin; Cell Line, Tumor; Cellulose; Cyclodextrins; Drug Delivery Systems; Humans; Mice; Nanoparticles; Neoplasms; Rotaxanes; Vitamin E; Xenograft Model Antitumor Assays | 2019 |
Carrier-Free, Dual-Functional Nanorods Via Self-Assembly Of Pure Drug Molecules For Synergistic Chemo-Photodynamic Therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chlorophyllides; Drug Delivery Systems; Drug Liberation; Drug Stability; Drug Synergism; Female; Mice, Inbred BALB C; Molecular Dynamics Simulation; Nanotubes; Photochemotherapy; Photosensitizing Agents; Porphyrins; Reactive Oxygen Species | 2019 |
Preparation of PLGA microspheres loaded with 10-hydroxycamptothecin and arsenic trioxide and their treatment for rabbit hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Camptothecin; Carcinoma, Hepatocellular; Disease Models, Animal; Liver Neoplasms; Microspheres; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits | 2021 |
Mechanistic biosynthesis of SN-38 coated reduced graphene oxide sheets for photothermal treatment and care of patients with gastric cancer.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Graphite; Humans; Infrared Rays; Microscopy, Fluorescence; Stomach Neoplasms | 2020 |
Construction of Bispecific Aptamer-Drug Conjugate by a Hybrid Chemical and Biological Approach.
Topics: Aminobenzoates; Aptamers, Nucleotide; Camptothecin; Cell Line, Tumor; Fluorouracil; Humans; Oligopeptides; Pharmaceutical Preparations | 2020 |
Lysine-mediated hydroxyethyl starch-10-hydroxy camptothecin micelles for the treatment of liver cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; Drug Carriers; Drug Delivery Systems; Drug Liberation; Hep G2 Cells; Humans; Hydroxyethyl Starch Derivatives; Liver Neoplasms; Lysine; Male; Mice; Mice, Nude; Micelles; Rats, Wistar; Tissue Distribution | 2020 |
Glycyrrhetinic Acid and TAT Peptide Modified Dual-functional Liposomes for Treatment of Hepatocellular Cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Glycyrrhetinic Acid; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Peptide Fragments; Surface Properties; tat Gene Products, Human Immunodeficiency Virus; Tumor Cells, Cultured | 2020 |
Drug-Bearing Peptide-Based Nanospheres for the Inhibition of Metastasis and Growth of Cancer.
Topics: A549 Cells; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; HeLa Cells; Hep G2 Cells; Humans; Melanoma, Experimental; Nanospheres; Nanostructures; Neoplasms; Peptides; Small Molecule Libraries | 2020 |
One-step electrodeposition preparation of polyaniline/f-MWCNTs as electrochemical sensors for detection of 10-hydroxycamptothecine.
Topics: Aniline Compounds; Biosensing Techniques; Camptothecin; Electrochemical Techniques; Electrodes; Nanotubes, Carbon | 2021 |
Melatonin Reverses 10-Hydroxycamptothecin-Induced Apoptosis and Autophagy in Mouse Oocyte.
Topics: Animals; Apoptosis; Autophagy; Camptothecin; Female; Melatonin; Mice; Mitochondria; Oocytes; Oogenesis; Oxidative Stress; Reactive Oxygen Species | 2021 |
Enhanced Stability of the Pharmacologically Active Lactone Form of 10-Hydroxycamptothecin by Self-Microemulsifying Drug Delivery Systems.
Topics: Administration, Oral; Animals; Biological Availability; Camptothecin; Drug Delivery Systems; Drug Stability; Emulsions; Male; Particle Size; Solubility | 2020 |
Supramolecular nanofibers increase the efficacy of 10-hydroxycamptothecin by enhancing nuclear accumulation and depleting cellular ATP.
Topics: Adenosine Triphosphate; Animals; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Hydrogels; Mice; Nanofibers | 2021 |
A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Humans; Light; Phthalimides; Prodrugs | 2021 |
Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O
Topics: Animals; Antineoplastic Agents; Camptothecin; Catalysis; Cell Line, Tumor; Drug Carriers; Drug Liberation; Female; Humans; Hydrogen Peroxide; Light; Methylene Blue; Mice, Inbred BALB C; Nanostructures; Neoplasms; Oxygen; Photosensitizing Agents; Photothermal Therapy; Platinum; Polymers; Porosity; Singlet Oxygen; Theranostic Nanomedicine; Tumor Hypoxia | 2021 |
A novel polymer micelle as a targeted drug delivery system for 10-hydroxycamptothecin with high drug-loading properties and anti-tumor efficacy.
Topics: Camptothecin; Drug Carriers; Drug Delivery Systems; Micelles; Particle Size; Polyethylene Glycols; Polymers | 2021 |
A modular ROS-responsive platform co-delivered by 10-hydroxycamptothecin and dexamethasone for cancer treatment.
Topics: Camptothecin; Cell Line, Tumor; Dexamethasone; Drug Delivery Systems; Drug Liberation; Micelles; Nanoparticles; Neoplasms; Reactive Oxygen Species | 2021 |
A natural product, (S)-10-Hydroxycamptothecin inhibits pseudorabies virus proliferation through DNA damage dependent antiviral innate immunity.
Topics: Animals; Antiviral Agents; Biological Products; Camptothecin; Cell Line; Cell Proliferation; DNA Damage; Herpesvirus 1, Suid; Immunity, Innate; Mice; Pseudorabies; Pseudorabies Vaccines; Rodent Diseases; Swine; Swine Diseases | 2022 |
Preparation, physicochemical and pharmacological study of 10-hydroxycamptothecin solid dispersion with complexation agent - xylan-nonanoic acid amphiphilic conjugates.
Topics: Camptothecin; Cell Line, Tumor; Drug Carriers; Fatty Acids; Micelles; Xylans | 2022 |
10-hydroxycamptothecin-loaded starch-based microcapsules with the stepwise responsive release strategy for targeted controlled release.
Topics: Camptothecin; Capsules; Cell Line, Tumor; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Glutathione; Nanoparticles; Reactive Oxygen Species; Starch | 2023 |
Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin.
Topics: Camptothecin; Head and Neck Neoplasms; Humans; Squamous Cell Carcinoma of Head and Neck | 2023 |