camostat has been researched along with gabexate in 275 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (27.27) | 18.7374 |
| 1990's | 108 (39.27) | 18.2507 |
| 2000's | 46 (16.73) | 29.6817 |
| 2010's | 29 (10.55) | 24.3611 |
| 2020's | 17 (6.18) | 2.80 |
| Authors | Studies |
|---|---|
| Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
| Birchall, K; Chapman, TM; Desai, B; Klefström, J; Mukonoweshuro, A; Pant, SM; Ramjee, MK; Selway, CN; Tarver, GJ; Tervonen, TA; Wright, AG | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Hirano, T; Manabe, T; Printz, H; Tobe, T | 1 |
| Asami, T; Hashimoto, K; Ohsawa, S; Sakai, K; Tomisawa, S; Toyabe, S | 1 |
| Harada, E; Hashimoto, Y; Syuto, B | 1 |
| Bilski, J; Konturek, PK; Konturek, SJ; Krzyzek, E | 1 |
| Matsubara, M; Saito, T; Taguma, Y; Yoshinaga, K | 2 |
| Ishikawa, T; Kanno, T | 1 |
| Harada, E; Syuto, B | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Ren, LM; Yonekura, H | 1 |
| Fuji, M; Fujisawa, T; Itoh, H; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Takeuchi, T; Toki, F; Yoshida, K | 1 |
| Fujii, S; Ino, Y; Iwaki, M; Kuramoto, S; Nakamura, K; Oda, M; Shimamura, K | 1 |
| Göke, B; Herzig, KH; Louie, DS; May, D; Owyang, C; Takahashi, T | 1 |
| Ishizuka, J; Parekh, D; Rajaraman, S; Thompson, JC; Townsend, CM | 2 |
| Ikeda, S; Morioka, S; Ogawa, H | 1 |
| Takeda, K | 1 |
| Iwakura, Y; Iwamoto, T; Miyazaki, M; Morimoto, K; Nakai, Y; Nakatani, E; Ohashi, Y; Yamaguchi, H | 1 |
| Chey, WY; Takeuchi, T; Watanabe, S | 1 |
| Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA | 1 |
| Fukushima, M; Haramoto, T; Kumagai, I; Makino, H; Murakami, K; Ogura, T; Onbe, T; Ota, Z; Wada, J | 1 |
| Bilski, J; Konturek, SJ; Krzyzek, E | 1 |
| Asano, N; Imanishi, K; Manabe, T; Tobe, T; Yoshimura, T | 1 |
| Aoki, T; Inagaki, Y; Kashiwagi, H; Moriya, S; Omura, N | 1 |
| Awata, H; Doi, A; Inoshiri, S; Kamiyasu, K; Kawasaki, A; Okegawa, T; Omawari, N; Shinomiya, K; Suzuki, Y; Tanaka, M | 1 |
| Inoshiri, S; Kamiyasu, K; Kawasaki, A; Okegawa, T; Omawari, N | 1 |
| Mann, GE; Sweiry, JH | 1 |
| Ikeda, S; Ogawa, H | 1 |
| Adler, G; Arnold, R; Koop, I; Lindenthal, M; Schade, M; Trautmann, M | 1 |
| Kumagai, I; Makino, H; Murakami, K; Onbe, T; Ota, Z | 1 |
| Koide, H; Nakayama, S | 1 |
| Kanno, T; Terasawa, K | 1 |
| Göke, B | 1 |
| Asai, K; Funaki, C; Hayashi, T; Kuzuya, F; Kuzuya, M; Naito, M; Yasue, M | 1 |
| Adler, G; Elsässer, HP; Kern, HF; Puplat, D | 1 |
| Ferrell, LD; Grendell, JH; Lüthen, R; Niederau, C; Niederau, M; Strohmeyer, G | 1 |
| Alves, F; Creutzfeldt, W; Fölsch, UR; Löser, C; Stöckmann, F | 1 |
| Kuhlmann, ET; Longnecker, DS; Silverman, JA; Yager, JD; Zurlo, J | 1 |
| Higashi, T; Machida, K; Matsumoto, O; Matsushima, M; Taga, T | 1 |
| Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 1 |
| Cherian, L; Goebell, H; Jansen, JB; Lamers, CB; Layer, P | 1 |
| Bremner, A; Dockray, GJ; Elliot, M; Forster, ER; Green, T | 1 |
| Creutzfeldt, W; Fussek, M; Leonhardt, U; Seidensticker, F; Stöckmann, F | 1 |
| Hotta, O; Ishizaki, M; Kurosawa, K; Matsubara, M; Suzuki, K; Taguma, Y | 1 |
| Freise, J; Magerstedt, P; Schmid, K; Schmidt, FW | 1 |
| Adler, G; Kern, HF; Koop, I; Rausch, U; Rudolff, D; Weidenbach, F; Weidenbach, H | 1 |
| Adler, G; Kern, HF; Rausch, U; Weidenbach, H | 1 |
| Lankisch, PG; Otto, J; Pohl, U; Wereszczyńska-Siemiatkowska, U | 1 |
| Grendell, JH; Liddle, RA; Niederau, C; Williams, JA | 1 |
| Alfen, R; Ehlers, J; Goebell, H; Jäger, M; Müller, MK; Plümpe, H | 1 |
| Baba, H; Inuzuka, T; Miyatake, T; Sato, S | 2 |
| Adler, G; Göke, B; Keim, V | 1 |
| Leli, U; Ohshio, G; Saluja, AK; Sengupta, A; Steer, ML | 1 |
| Freise, J; Magerstedt, P; Wittenberg, H | 1 |
| Adler, G; Göke, B; Göke, R; Leferink, J | 1 |
| Adler, G; Göke, B; Koop, I; Printz, H; Schafmayer, A; Weidenbach, H | 1 |
| Aki, T; Baba, N; Nishimura, I; Suzuki, T; Tobe, T; Tsai, G | 1 |
| Bamba, T; Hosoda, S; Nakagawa, M; Oishi, T | 1 |
| Aikawa, I; Arakawa, K; Nakajima, H; Ohmori, Y; Oka, T; Yasumura, T; Yoshida, T | 1 |
| Ando, M; Kaneko, F; Nagai, M; Oguchi, H; Ohkawara, A; Oikawa, K; Tsukinaga, I | 1 |
| Cleffmann, U; Creutzfeldt, W; Fölsch, UR; Löser, C; Nustede, R | 1 |
| Inoki, R; Kudo, T; Wei, EQ | 2 |
| Keane, FB; Leahy, AL; Redmond, HP; Tanner, WA | 1 |
| Hirano, H; Ishizuka, H; Koizumi, M; Murakami, M; Ohira, C; Sato, K; Shimoda, I; Tanno, N; Toyota, T | 1 |
| Choudhury, AR; Creutzfeldt, W; Fölsch, UR; Nustede, R; Schmidt, WE; Siegel, EG; Stöckmann, F; Wilms, HM | 1 |
| Dembinski, A; Jaworek, J; Konturek, PK; Konturek, SJ; Warzecha, Z | 1 |
| Adler, G; Arnold, R; Göke, B; Koop, I; Reinshagen, M; Rovati, LC; Schafmayer, A | 1 |
| de Jong, AJ; Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 1 |
| Kitani, K; Miyasaka, K; Nakamura, R | 1 |
| Hirano, H; Ishizuka, J; Koizumi, M; Sato, K; Shimoda, I; Tanno, N; Toyota, T | 1 |
| Futaki, G; Hotta, O; Kurosawa, K; Matsubara, M; Suzuki, K; Taguma, Y | 1 |
| Mann, GE; Muñoz, M | 1 |
| Kobayashi, M; Watanabe, A; Yamauchi, Y | 1 |
| Göke, B; Gröne, HJ; Lankisch, PG; Otto, J; Pohl, U; Rahlf, G; Wereszczynska-Siemiatkowska, U | 1 |
| Bönner, G; Büchsler, U; Frericks, A; Kaufmann, W | 1 |
| Babst, H; Bönner, G; Kaufmann, W | 1 |
| Dimaline, R; Dockray, GJ; Green, T; Peikin, S | 1 |
| Adler, G; Arnold, R; Beglinger, C; Bozkurt, T; Göke, B; Koop, I; Müllenhoff, A | 1 |
| Lankisch, PG; Otto, J; Pohl, U | 1 |
| Adler, G; Arnold, R; Fenchel, K; Göke, B; Knobloch, S | 1 |
| Ammon, HP; Verspohl, EJ; Wunderle, G | 1 |
| Hayakawa, T; Kitagawa, M; Kondo, T; Shibata, T; Sugimoto, Y | 1 |
| Nishihata, T; Saitoh, Y; Sakai, K | 1 |
| Ikawa, C; Nishihata, T; Sakai, K; Yoshitomi, H | 1 |
| Chen, DL; Morioka, S; Nakajima, S; Ogawa, H | 1 |
| Higuchi, E; Kamiyama, S; Kato, K; Kumaki, S; Kume, K; Nozawa, R; Ohara, N; Suzuki, J; Suzuki, S; Yugeta, E | 1 |
| Alves, F; Cleffmann, U; Creutzfeldt, W; Fölsch, UR; Löser, C | 1 |
| Lhoste, EF; Longnecker, DS; Roebuck, BD | 1 |
| McLaughlin, RE; Ozawa, S; Renner, IG; Rich, KA; Wisner, JR | 1 |
| Adler, G; Arnold, R; Bozkurt, T; Göke, B; Koop, I; Müllenhoff, A | 1 |
| Ikeda, S; Manabe, M; Muramatsu, T; Ogawa, H; Takamori, K | 1 |
| Arnold, R; Beckh, K; Göke, B; Müller, R | 1 |
| Fuchinoue, S; Honda, H; Kawai, T; Sanaka, T; Takahashi, K; Tanabe, K; Teraoka, S; Toma, H; Yagisawa, T; Yamaguchi, Y | 1 |
| Adler, G; Arnold, R; Göke, B; Koop, I; Printz, H; Rausch, U; Richter, G | 1 |
| Himeno, S; Kanayama, S; Kitani, T; Shinomura, Y; Tarui, S; Yamasaki, Y | 1 |
| Baba, S; Ohki, A; Okabayashi, Y; Otsuki, M; Suehiro, I | 1 |
| Higashimoto, Y; Kawamoto, H; Kuroshima, T; Tsuji, K; Yamasaki, Y | 1 |
| Creutzfeldt, W; Göke, B; Lankisch, PG; Siegel, EG; Stöckmann, F | 1 |
| Göke, B; Göke, R; Lankisch, PG | 1 |
| Baba, S; Maeda, M; Morita, S; Ohki, A; Otsuki, M; Sakamoto, C; Terashi, K; Yamasaki, T | 1 |
| Harada, E; Kato, S; Nakagawa, K | 1 |
| Freise, J; Magerstedt, P; Schmid, K | 1 |
| Adler, G; Arnold, R; Kern, HF; Rausch, U; Weidenbach, F | 1 |
| Creutzfeldt, W; Göke, B; Lankisch, PG; Otto, J; Stöckmann, F | 1 |
| Baile, CA; McLaughlin, CL; Peikin, SR | 1 |
| Creutzfeldt, W; Göke, B; Lankisch, PG; Müller, R; Stöckmann, F | 1 |
| Chang, HL; Inoki, R; Kudo, T; Maeda, S; Nakamae, J; Uchida, Y | 1 |
| Fujii, S; Ohkoshi, M | 3 |
| Eto, M; Futaki, G; Ishii, K; Kagaya, T; Oyama, K; Saito, T; Sakai, Y; Takebe, T; Watanabe, K; Yoshida, S | 1 |
| Baba, N; Suzuki, T; Tobe, T | 1 |
| Bohn, E; Kunze, H | 1 |
| Yonezawa, H | 2 |
| Ohkoshi, M; Oka, T | 1 |
| Ohkoshi, M | 2 |
| Goebell, H; Müller, MK; Rünzi, M; von Schönfeld, J | 1 |
| Creutzfeldt, W; Leonhardt, U; Seidensticker, F; Stöckmann, F | 1 |
| Denno, R; Hirata, K; Mikami, T; Oikawa, I | 1 |
| Fujii, M; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Akizawa, Y; Ino, Y; Johmura, A; Kurumi, M; Miyazaki, H; Nakamura, K; Oda, M; Ohtani, H; Oka, T; Uchiyama, H | 1 |
| Büchler, M; Friess, H; Gorácz, UG; Kisfalvi, K; Papp, M | 1 |
| Assmann, V; Hensel, G; Kern, HF | 1 |
| Fölsch, UR; Jäger, M; Köhler, H; Nustede, R; Peiper, HJ; Schmidt, WE; Stöckmann, F | 1 |
| Hopman, WP; Jansen, JB; Lamers, CB; Rosenbusch, G; Sloots, CE; Tangerman, A; Thimister, PW; Willems, HL | 1 |
| Büchler, M; Friess, H; Hajnal, F; Kisfalvi, K; Papp, M; Varga, G | 1 |
| Hollinshead, M; Kern, HF; Kömhoff, M; Tooze, J | 1 |
| Goebell, H; Müller, MK; Rünzi, M | 1 |
| Aze, Y; Furukawa, F; Imazawa, T; Nishikawa, A; Sato, M; Takahashi, M; Yoshimura, H | 1 |
| Bonn, R; Brindley, CJ; Chasseaud, LF; Cheng, KN; Hood, AJ; Irons, SR; Midgley, I; Proctor, P | 1 |
| Chang, CH; Chang, TM; Chey, WY; Leiter, A; Sun, Q | 1 |
| Köhler, H; Lüdtke, FE; Nustede, R; Streich, R | 1 |
| Asano, N; Imamura, T; Manabe, T; Ohshio, G; Suwa, H; Yoshimura, T | 1 |
| Fölsch, UR; Löser, C | 1 |
| Fukumoto, M; Hayashi, H; Imamura, M; Kawabata, K; Manabe, T; Masai, Y; Morimoto, H; Nio, Y; Tsubono, M | 1 |
| Köhler, H; Nustede, R; Schafmayer, A | 1 |
| Yamamoto, Y | 1 |
| De Clercq, E; Hosoya, M; Ishii, T; Shigeta, S; Suzuki, H | 1 |
| Bamba, T; Fujiyama, Y; Hosoda, S; Senda, S | 1 |
| Ge, YC; Morgan, RG | 1 |
| Gu, Y; Imamura, M; Inoue, K; Kogire, M; Uchida, K | 1 |
| Ishizuka, J; Koizumi, M; Ono, T; Sato, K; Shimoda, I; Shimosegawa, T; Shishido, T; Toyota, T | 1 |
| Watanapa, P; Williamson, RC | 1 |
| Fujii, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Hopman, WP; Jansen, JB; Rosenbusch, G; Sloots, CE; Thimister, PW; Trijbels, FJ; Willems, HL | 1 |
| Furugo, I; Horiuchi, T; Nagasawa, K; Niho, Y; Tsukamoto, H; Tsuru, T; Ueda, Y; Yoshizawa, S | 1 |
| Agricola, B; Kern, HF; Kruse, ML; Schmidt, WE; Waschulewski, IH | 1 |
| Atomi, Y; Kobori, O; Kuroda, A; Muto, T; Sugiyama, M; Wada, N | 1 |
| Scarpignato, C; Varga, G | 1 |
| Iguchi, Y; Katori, M; Majima, M; Nishiyama, K; Yao, K | 1 |
| Arakawa, H; Futagami, F; Kayahara, M; Kitagawa, H; Miyazaki, I; Nagakawa, T; Ohta, T; Tsukioka, Y | 1 |
| Büchler, MW; Friess, H; Kisfalvi, K; Papp, M; Tulassay, Z; Varga, G | 1 |
| Kim, JS; Kim, KH; Lee, MG; Park, KY | 1 |
| Hoshino, T; Ikeda, T | 1 |
| Meisse, F; Müller, MK; von Schönfeld, J | 1 |
| Higashi, T; Kinugasa, N; Nakatsukasa, H; Nishimura, Y; Nouso, K; Satoh, Y; Shiota, T; Tsuji, T; Uematsu, S; Yoshida, K | 1 |
| Kim, DG; Kim, KH; Lee, MG | 1 |
| Green, GM; Guan, D; Phillips, WT; Schwartz, JG | 1 |
| Emi, Y; Fujita, T; Horisaka, E; Muranishi, S; Tozaki, H; Yamamoto, A | 1 |
| Fölsch, UR; Löser, C; Torff, L | 1 |
| Endo, T; Kume, E; Nagasaki, M; Shikano, T; Taniguchi, H; Yomota, E | 1 |
| Atomi, Y; Kuroda, A; Muto, T; Sugiyama, M; Wada, N | 1 |
| Fitting, T; Fölsch, UR; Löser, C | 1 |
| Arai, I; Hirai, Y; Ida, Y; Komatsu, Y; Kuroiwa, Y; Sasaki, K; Shingu, K; Taguchi, S; Yamamoto, T; Yamaura, H | 1 |
| Otsuki, M; Shirohara, H; Yamamoto, M | 1 |
| Kashima, K; Kataoka, K; Sakagami, J; Sasaki, T; Yorizumi, H | 1 |
| Abe, S; Kamei, C; Tagami, H; Tanaka, I; Yoshida, Y | 2 |
| Hiwasa, T; Kondo, K; Nakagawara, A; Ohkoshi, M | 1 |
| D'Amato, M; Kisfalvi, K; Pelosini, I; Scarpignato, C; Varga, G | 1 |
| Büchler, MW; Friess, H; Isenmann, R; Kleeff, J; Malfertheiner, P | 1 |
| Ishii, H; Ishikawa, H; Kitajima, M; Kubota, T; Kumal, K; Kurose, I; Miura, S; Otani, Y; Shimazu, M; Wakabayashi, G; Yoshida, M | 1 |
| Fujita, T; Iseki, T; Murakami, M; Muranishi, S; Odoriba, T; Taniguchi, T; Tozaki, H; Yamamoto, A | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R | 1 |
| Fukui, K; Irimura, K; Oda, M; Oka, T; Yuasa, C | 1 |
| Aoyama, Y; Hara, H; Hira, T | 1 |
| Chen, C; Hatori, S; Imada, T; Rino, Y; Shiozawa, M | 1 |
| Funakoshi, A; Kanai, S; Kawanami, T; Miyasaka, K; Shimazoe, T; Suzuki, S; Takata, Y; Watanabe, S; Yoshida, Y | 1 |
| Bragado, MJ; Tashiro, M; Williams, JA | 1 |
| Fink, H; Voigt, JP; Voits, M; Wenz, D | 1 |
| Amano, I; Morii, T; Narita, N; Tanaka, H; Tsukaguchi, N; Yagi, H; Yoneda, K | 1 |
| Matsuyama, K; Uchida, T; Yasuda, N | 1 |
| Bamba, T; Fujiyama, Y; Nakamura, F; Saotome, T; Shintani, Y | 1 |
| Akita, K; Ikeda, K; Kaneda, K; Kawada, N; Kojima, S; Moriwaki, H; Okuno, M; Suzuki, Y | 1 |
| Iovanna, JL; Motoo, Y; Sawabu, N; Su, SB; Xie, MJ | 1 |
| Ito, S; Matsubara, M; Nogae, S | 1 |
| Kistler, EB; Mitsuoka, H; Schmid-Schönbein, GW | 1 |
| Fukuda, N; Nakamori, Y; Oeda, E; Sato, Y; Shimohakamada, Y; Shinohara, K; Takahashi, T; Tominaga, T | 1 |
| Funakoshi, A; Jimi, A; Kanai, S; Miyasaka, K; Noda, T; Ohta, M; Sato, N; Suzuki, S; Takiguchi, S | 1 |
| Chew, P; Eysselein, VE; Green, GM; Keire, DA; Reeve, JR | 1 |
| Amasaki, H; An, T; Mutoh, K; Nagasao, J; Sugiyama, D; Yoshioka, K; Yue, Z | 1 |
| Ban, S; Kakefuda, R; Kikukawa, Y; Nagahiro, K; Sawada, H; Shiomi, T; Yokosawa, H | 1 |
| Aizawa, Y; Enomoto, Y; Matsuoka, M; Miyagawa, Y; Okuaki, Y; Saito, A; Suto, S; Toda, G; Tsuruta, Y | 1 |
| Green, GM; Jin, W | 1 |
| Liddle, RA; Samuelson, LC; Tashiro, M; Williams, JA | 1 |
| Ishikawa, H; Kameyama, K; Kawachi, S; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Saikawa, Y; Sano, K; Shimazu, M; Tanabe, M; Wakabayashi, G; Yoshida, M | 1 |
| Asami, T; Tomisawa, S; Uchiyama, M | 1 |
| Kamisawa, T | 1 |
| Iovanna, JL; Jiang, PH; Motoo, Y; Okada, G; Pébusque, MJ; Sawabu, N; Xie, MJ | 1 |
| Akashi, T; Arita, Y; Funakoshi, A; Gibo, J; Inoue, N; Ito, T; Kawabe, K; Nawata, H; Oono, T | 1 |
| Arita, Y; Fujimori, N; Gibo, J; Hisano, T; Inoue, M; Ito, T; Kawabe, K; Nawata, H; Oono, T | 1 |
| Green, GM; Keire, DA; Reeve, JR; Yamamoto, M | 1 |
| Jia, D; Otsuki, M; Taguchi, M | 2 |
| Emori, Y; Ichimura, M; Koide, N; Matsumura, N; Mizushima, T; Ochi, K; Shinji, T; Shirahige, A; Tanimoto, M; Tanioka, H | 1 |
| Hazemoto, N; Noda, Y; Yin, J; Yotsuyanagi, T | 1 |
| Fujii, H; Kamiyasu, K; Kono, K; Sugai, H; Takahashi, A; Teramatsu, M; Umekawa, T; Yano, T | 1 |
| Basu, SK; Kim, KJ; Lee, VH; Sun, L | 1 |
| Noda, Y; Yin, J; Yotsuyanagi, T | 1 |
| Crozier, SJ; D'Alecy, LG; Guo, L; Sans, MD; Williams, JA | 1 |
| Dabrowski, A; Guo, L; Sans, MD; Tashiro, M; Williams, JA | 1 |
| Ashizawa, N; Hashimoto, T; Imaoka, T; Kinoshita, Y; Miyake, T; Shizuku, T | 1 |
| Li, YQ; Motoo, Y; Shen, HY; Su, SB; Yoshiharu, M | 1 |
| Ernst, SA; Guo, L; Gurda, GT; Lee, SH; Sans, MD; Williams, JA | 1 |
| Ishiki, T; Ishikura, H; Kamanaka, Y; Kawabata, A; Matsunami, M; Nakatani, T; Naruse, M; Nishimura, S; Sekiguchi, F; Tsujiuchi, T | 1 |
| Funakoshi, A; Ito, T; Itoi, T; Kuroda, Y; Naruse, S; Otsuki, M; Shimosegawa, T; Shiratori, K | 1 |
| Nagashio, Y; Otsuki, M | 1 |
| Motoo, Y | 1 |
| Guo, L; Gurda, GT; Lee, SH; Molkentin, JD; Williams, JA | 1 |
| Cheung, DY; Cho, SH; Han, JY; Kim, JI; Kim, JK; Park, SH; Park, YB; Sung, HY | 1 |
| Crozier, SJ; D'Alecy, LG; Ernst, SA; Lang, CH; Sans, MD; Williams, JA | 1 |
| Cooper, MS; Green, GM; Raboin, SJ; Reeve, JR; Sayegh, AI | 1 |
| Adachi, M; Kakizoe, Y; Kitamura, K; Ko, T; Maekawa, A; Miyoshi, T; Shiraishi, N; Tomita, K; Wakida, N | 1 |
| Abraham, WM; Atherton-Watson, HC; Bhalay, G; Bloomfield, G; Bridges, RJ; Coote, K; Danahay, H; Dunstan, A; Gosling, M; Harris, J; MacKenzie-Beevor, A; Pacoma, R; Sabater, JR; Schumacher, A; Sugar, R; Tully, D; Young, A | 1 |
| Bursulaya, B; Danahay, H; Harris, JL; Hornsby, M; Lesley, SA; Shipway, A; Spraggon, G; Tully, DC | 1 |
| Inami, K; Kubokawa, Y; Matsumura, Y; Sai, JK; Suyama, M; Watanabe, S | 1 |
| Dagvadorj, J; Hiwasa, T; Iftakhar-E-Khuda, I; Koide, N; Komatsu, T; Naiki, Y; Ookoshi, M; Tumurkhuu, G; Yokochi, T; Yoshida, T | 1 |
| Crozier, SJ; Ernst, SA; Gurda, GT; Ji, B; Logsdon, CD; Rothermel, BA; Williams, JA | 1 |
| Hide, M; Kameyoshi, Y; Shindo, H; Takahagi, S; Watanabe, M | 1 |
| Lateef, DM; Sayegh, AI; Washington, MC | 1 |
| Del Curto, MD; Gazzaniga, A; Maroni, A; Palugan, L; Sangalli, ME; Zema, L | 1 |
| Kitamura, K; Tomita, K | 1 |
| Lateef, DM; Mansour, MM; Raboin, SJ; Roberson, AE; Sayegh, AI; Washington, MC; Williams, CS | 1 |
| Chu, J; Cruz-Monserrate, Z; Daniluk, J; Deng, D; Gaiser, S; Huang, H; Ji, B; Liu, Y; Logsdon, CD; Wang, H | 1 |
| Adachi, M; Hayata, M; Kakizoe, Y; Kitamura, K; Miyoshi, T; Mizumoto, T; Morinaga, J; Onoue, T; Sakai, Y; Shiraishi, N; Tomita, K; Uchimura, K; Ueda, M; Yamazoe, R | 3 |
| Abbi, S; Clancy, JP; Danahay, H; Hathorne, H; Lock, R; Reeves, G; Renard, D; Rowe, SM; Solomon, GM; Waltz, DA; Zhou, P | 1 |
| Kawase, M; Matsuyama, S; Shirato, K | 1 |
| Cheung, DY; Cho, HJ; Cho, SH; Kim, JI; Kim, JK; Kim, SS; Lee, HJ; Sung, HY | 1 |
| Dong, L; Song, Y; Wang, Z; Zhao, J; Zou, B | 1 |
| Agudelo, J; Barnard, D; Carrion, R; Lu, K; McKerrow, JH; Nunneley, JW; Pöhlmann, S; Renslo, AR; Simmons, G; Vedantham, P; Zhou, Y | 1 |
| Adachi, M; Hayata, M; Kadowaki, D; Kakizoe, Y; Kitamura, K; Miyasato, Y; Miyoshi, T; Mizumoto, T; Morinaga, J; Mukoyama, M; Narita, Y; Sakai, Y; Shiraishi, N; Uchimura, K; Ueda, M | 1 |
| Hatachi, Y; Homma, M; Hongo, S; Kitajima, Y; Kubo, H; Lusamba Kalonji, N; Matsuo, K; Nagatomi, R; Nishimura, H; Shimotai, Y; Tando, Y; Yamaya, M | 1 |
| Jia, D; Otsuki, M; Yamamoto, M | 1 |
| Chen, J; Guo, H; Huang, Y; Liu, C; Shan, W; Xiao, Z | 1 |
| Caughey, GH; Gruenert, DC; Nimishakavi, S; Raymond, WW | 1 |
| Sayegh, AI; Washington, MC; Williams, K | 1 |
| Adachi, M; Hayata, M; Hirata, S; Kadowaki, D; Kakizoe, Y; Kitamura, K; Miyasato, Y; Miyoshi, T; Mizumoto, T; Morinaga, J; Mukoyama, M; Nakagawa, T; Narita, Y; Sakai, Y; Uchimura, K; Ueda, M | 1 |
| Arai, M; Haga, Y; Iino, Y; Kanda, T; Kumagai, J; Nakamoto, S; Nakamura, M; Sasaki, R; Wu, S; Yasui, S; Yokosuka, O | 1 |
| Agawa, S; Futagami, S; Gudis, K; Higuchi, K; Iwakiri, K; Kaneko, K; Kawamoto, C; Kodaka, Y; Murakami, M; Sakasegawa, N; Ueki, N; Wakabayashi, M; Yamawaki, H | 1 |
| Hart, PA; Nuttall, J; Ramsey, ML | 1 |
| Drosten, C; Erichsen, S; Herrler, G; Herrler, T; Hoffmann, M; Kleine-Weber, H; Krüger, N; Müller, MA; Nitsche, A; Pöhlmann, S; Schiergens, TS; Schroeder, S; Wu, NH | 1 |
| Henrickson, SE | 1 |
| Antonarakis, ES; Kantoff, PW; Mucci, LA; Nelson, PS; Stopsack, KH | 1 |
| Uno, Y | 1 |
| Fang, Y; Meng, XM; Ni, WJ; Shen, AZ; Xu, T; Zhou, H | 1 |
| Basharat, Z; Castaldo, G; Khan, H; Rahman, N; Rastrelli, L; Yousuf, M | 1 |
| Deng, X; Kikuchi, A; Nagatomi, R; Nishimura, H; Yamaya, M | 1 |
| Drakoulis, N; Ion, GND; Moschos, SA; Nikolouzakis, TK; Nitulescu, G; Nitulescu, GM; Paunescu, H; Petrakis, D; Spandidos, DA; Tsatsakis, A | 1 |
| Gohda, J; Imai, M; Inoue, JI; Iwatsuki-Horimoto, K; Kawaguchi, Y; Kawaoka, Y; Kinoshita, N; Kiso, M; Matsuda, Z; Ohmagari, N; Sakai-Tagawa, Y; Semba, K; Takeda, M; Yamamoto, M | 1 |
| Cleland, E; Giovane, RA; Henderson, CE; Rezai, S | 1 |
| Massari, F; Mollica, V; Rizzo, A | 1 |
| Al-Rejaie, S; ElMasry, G; Kishk, RM; Kishk, SM; Nafie, MS; Nemr, NA; Simons, C; Yassen, ASA | 1 |
| Banerjee, DI; Darji, SA; Lipsa Rath, S; Toor, HG | 1 |
| Barygin, OI; Zhigulin, AS | 1 |
| Barygin, OI; Tikhonov, DB; Zhigulin, AS | 1 |
| C, AM; Ponnuraj, K; Wessler, S | 1 |
14 review(s) available for camostat and gabexate
| Article | Year |
|---|---|
A critical appraisal of studies of the pancreas. Animal models used in pancreas research: studies on feedback regulations of the pancreas.
Topics: Animals; Esters; Feedback; Gabexate; Guanidines; Humans; Pancreas; Peptide Hydrolases; Species Specificity | 1990 |
[Protease inhibitors as anticancer chemotherapy--experimental and clinical studies].
Topics: Adenocarcinoma; Animals; Carcinoma, Lewis Lung; Carcinoma, Squamous Cell; Cell Division; Colonic Neoplasms; Esters; Gabexate; Guanidines; Humans; Mice; Mouth Neoplasms; Neoplastic Cells, Circulating; Protease Inhibitors; Skin Neoplasms | 1995 |
[Clinical study of chronic pancreatitis].
Topics: Alcohol Drinking; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Esters; Fasting; Female; Gabexate; Guanidines; Humans; Male; Pancreatic Function Tests; Pancreatitis; Prognosis; Tomography, X-Ray Computed | 1993 |
Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation.
Topics: Animals; Cricetinae; Diet; Disease Models, Animal; Energy Intake; Esters; Flour; Gabexate; Glycine max; Guanidines; Humans; Hyperplasia; Mice; Nitrosamines; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms; Rats | 1993 |
[Inhibitory effect of FOY-305 on liver metastasis of the pancreatic cancer].
Topics: Animals; Esters; Gabexate; Guanidines; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Protease Inhibitors; Tumor Cells, Cultured | 1996 |
[A case of groove pancreatitis pure type treated with conservative therapy].
Topics: Chronic Disease; Drug Therapy, Combination; Esters; Gabexate; Guanidines; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pancreatitis; Parenteral Nutrition, Total | 2003 |
[Autoimmune pancreatitis].
Topics: Autoimmune Diseases; Diagnostic Imaging; Diet, Fat-Restricted; Drainage; Esters; Fasting; Gabexate; Guanidines; Hematologic Tests; Humans; Pancreatic Function Tests; Pancreatitis; Prednisolone; Protease Inhibitors | 2004 |
Action of antiproteases on fibrosis in experimental chronic pancreatitis.
Topics: Animals; Disease Models, Animal; Esters; Fibrosis; Gabexate; Guanidines; Pancreatitis, Chronic; Protease Inhibitors; Pyridines | 2007 |
Antiproteases in the treatment of chronic pancreatitis.
Topics: Animals; Esters; Gabexate; Guanidines; Humans; Pancreatitis, Chronic; Trypsin Inhibitors | 2007 |
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Topics: Animals; Epithelial Sodium Channels; Esters; Furin; Gabexate; Guanidines; Humans; Hypertension; Rats; Rats, Inbred Dahl; Serine Endopeptidases; Serine Proteinase Inhibitors | 2012 |
Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Esters; Female; Gabexate; Gene Expression Regulation; Genetic Predisposition to Disease; Guanidines; Humans; Influenza, Human; Male; Pandemics; Pneumonia, Viral; Prostatic Neoplasms; SARS-CoV-2; Serine Endopeptidases; Serine Proteinase Inhibitors | 2020 |
Potential therapeutic targets and promising drugs for combating SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Basigin; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Cytokine Release Syndrome; Esters; Gabexate; Genome, Viral; Guanidines; Humans; Immunization, Passive; Immunosuppressive Agents; Medicine, Chinese Traditional; Nucleic Acid Synthesis Inhibitors; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Viral Vaccines; Virus Internalization; Virus Replication | 2020 |
Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review).
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Betacoronavirus; Bromhexine; Chlorpromazine; Clinical Trials as Topic; Coronavirus Infections; COVID-19; Diminazene; Drug Repositioning; Esters; Gabexate; Guanidines; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Receptor, Angiotensin, Type 1; Recombinant Proteins; SARS-CoV-2; Signal Transduction; Virus Internalization | 2020 |
Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID-19) and the rationale for their utilization: A review.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antibodies, Monoclonal, Humanized; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Progression; Drug Combinations; Drug Repositioning; Esters; Gabexate; Gene Expression Regulation; Guanidines; Host-Pathogen Interactions; Humans; Hydroxychloroquine; Indoles; Lopinavir; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2020 |
10 trial(s) available for camostat and gabexate
| Article | Year |
|---|---|
Anti-proteinuric and anti-coagulatory effects of camostat mesilate in azotemic diabetics.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Blood Coagulation; Captopril; Diabetic Nephropathies; Drug Therapy, Combination; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Proteinuria; Uremia | 1992 |
Comparison of the effect of single and repeated administrations of a protease inhibitor (Camostate) on pancreatic secretion in man.
Topics: Cholecystokinin; Esters; Food; Gabexate; Guanidines; Humans; Pancreas; Protease Inhibitors; Time Factors | 1988 |
Role of intraduodenal proteases in plasma cholecystokinin and pancreaticobiliary responses to protein and amino acids.
Topics: Adult; Albumins; Amino Acids; Amylases; Bilirubin; Cholecystokinin; Chymotrypsin; Duodenum; Endopeptidases; Esters; Female; Gabexate; Gallbladder; Gallbladder Emptying; Guanidines; Humans; Male; Pancreas; Pancreatic Polypeptide; Protease Inhibitors; Trypsin | 1996 |
Urinary C4 excretion in systemic lupus erythematosus.
Topics: Adolescent; Adult; Blotting, Western; Complement Activation; Complement C4; DNA; Esters; Female; Gabexate; Guanidines; Hemolysis; Humans; Indicators and Reagents; Kidney Glomerulus; Lupus Erythematosus, Systemic; Male; Middle Aged; Protease Inhibitors; Proteinuria | 1995 |
Effect of oral camostat mesilate on hematuria and/or proteinuria in children.
Topics: Administration, Oral; Adolescent; Biopsy; Child; Child, Preschool; Esters; Female; Follow-Up Studies; Gabexate; Glomerulonephritis; Guanidines; Hematuria; Humans; Male; Protease Inhibitors; Proteinuria | 2004 |
Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity.
Topics: Administration, Oral; Aged; Esophagitis, Peptic; Esters; Female; Gabexate; Gastrectomy; Gastroenterostomy; Guanidines; Humans; Male; Middle Aged; Postoperative Complications; Statistics, Nonparametric; Trypsin; Trypsin Inhibitors | 2005 |
Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective?
Topics: Anti-Ulcer Agents; Dyspepsia; Esters; Famotidine; Female; Gabexate; Guanidines; Humans; Japan; Male; Middle Aged; Treatment Outcome; Trypsin Inhibitors | 2006 |
Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease.
Topics: Abdominal Pain; Adult; Aged; Dyspepsia; Endosonography; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Pain Measurement; Pancreatic Diseases; Prospective Studies; Protease Inhibitors; Severity of Illness Index; Treatment Outcome | 2010 |
Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis.
Topics: Administration, Intranasal; Adult; Biological Transport; Chlorides; Cross-Over Studies; Cystic Fibrosis; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Respiratory System; Serine Endopeptidases; Sodium; Treatment Outcome | 2013 |
A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pancreatitis, Chronic; Protease Inhibitors; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome; United States; Young Adult | 2019 |
251 other study(ies) available for camostat and gabexate
| Article | Year |
|---|---|
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
Topics: Breast Neoplasms; Cell Proliferation; Drug Design; Enzyme Inhibitors; Female; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Structure; Protein Conformation; Serine Endopeptidases; Tumor Cells, Cultured | 2018 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Cytotoxic effects of cyclosporin A on the exocrine pancreas in rats.
Topics: Amylases; Animals; Cathepsin B; Cyclosporine; Drug Evaluation, Preclinical; Edema; Esters; Gabexate; Guanidines; Injections, Subcutaneous; Lysosomes; Male; Pancreas; Pancreatic Juice; Rats; Rats, Wistar; Transplantation Immunology; Trypsin Inhibitors | 1992 |
Glomerular deposition of alpha 2-macroglobulin in a child with steroid refractory nephrotic syndrome.
Topics: alpha-Macroglobulins; Child, Preschool; Esters; Gabexate; Guanidines; Humans; Kidney Glomerulus; Male; Nephrotic Syndrome; Protease Inhibitors; Steroids | 1992 |
Precocious cessation of intestinal macromolecular transport by synthetic trypsin inhibitor in suckling rats.
Topics: Administration, Oral; Adrenalectomy; Animals; Animals, Suckling; Biological Transport; Cattle; Esters; Gabexate; Guanidines; Immunoglobulin G; Injections, Subcutaneous; Intestine, Small; Macromolecular Substances; Rats; Rats, Inbred Strains; Sincalide; Time Factors; Trypsin Inhibitors; Weight Gain | 1992 |
Feedback control of pancreatic secretion in rats. Role of gastric acid secretion.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Esters; Feedback; Gabexate; Gastric Acid; Gastric Fistula; Guanidines; Male; Omeprazole; Pancreas; Pancreatic Fistula; Protease Inhibitors; Rats; Rats, Wistar | 1992 |
Effect of camostat mesilate on persistent proteinuria of IgA nephropathy.
Topics: Administration, Oral; Adult; Esters; Female; Gabexate; Glomerulonephritis, IGA; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Proteinuria | 1992 |
Dissociation of CCK-8-induced fluid secretion from protein secretion by ion-transport blockers in rat pancreas.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Amiloride; Animals; Esters; Furosemide; Gabexate; Guanidines; Hypertrophy; Ouabain; Pancreas; Pancreatic Juice; Perfusion; Rats; Rats, Inbred Strains; Sincalide | 1992 |
Precocious alteration of digestive enzyme activities in small intestine and pancreas by chronic oral administration of protease inhibitor in suckling rats.
Topics: Administration, Oral; Adrenalectomy; Animals; Animals, Newborn; Benzodiazepinones; Cholecystokinin; Devazepide; Digestion; Esters; Gabexate; Guanidines; Injections, Subcutaneous; Intestine, Small; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aprotinin; Benzamidines; Bicarbonates; Body Water; Cyclic AMP; Dogs; Esters; Female; Gabexate; Glycoproteins; Guanidines; In Vitro Techniques; Male; Pancreas; Perfusion; Protease Inhibitors; Secretin | 1990 |
Beneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Esters; Gabexate; Guanidines; Male; Organ Size; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Secretin; Trypsin Inhibitors | 1990 |
[Antienzyme preparations in the treatment of acute pancreatitis].
Topics: Acute Disease; Adult; Aprotinin; Benzamidines; Cytidine Diphosphate Choline; Disseminated Intravascular Coagulation; Esters; Gabexate; Glycoproteins; Guanidines; Humans; Male; Multiple Organ Failure; Pancreatitis; Serine Proteinase Inhibitors; Trypsin Inhibitors | 1990 |
Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo.
Topics: Amylases; Animals; Chymotrypsin; Complement Inactivator Proteins; Complement Pathway, Classical; Esters; Fibrinolysin; Forssman Antigen; Gabexate; Guanidines; Guinea Pigs; Hyaluronoglucosaminidase; Imidazoles; Lipase; Male; Phospholipases A; Protease Inhibitors; Serine Endopeptidases; Trypsin Inhibitors | 1990 |
Intracellular mechanism responsible for reduced enzyme secretion from camostate-induced hypertrophied pancreas.
Topics: Amylases; Animals; Carbachol; Esters; Gabexate; Guanidines; Hypertrophy; Male; Pancreas; Phosphatidylinositols; Protease Inhibitors; Rats; Signal Transduction; Sincalide | 1990 |
Pancreatic regeneration after partial pancreatectomy.
Topics: Animals; DNA; Esters; Gabexate; Guanidines; Male; Organ Size; Pancreas; Pancreatectomy; Proteins; Rats; Rats, Inbred F344; Regeneration; RNA; Trypsin Inhibitors | 1991 |
Influence of culturing temperature and proteinase inhibitors on the spontaneously occurring changes in the organ culture of psoriatic skin.
Topics: Aprotinin; Culture Media; Esters; Gabexate; Guanidines; Humans; Organ Culture Techniques; Protease Inhibitors; Psoriasis; Serum Albumin, Bovine; Skin; Temperature; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors | 1990 |
[Protease inhibitors in the treatment of pancreatitis].
Topics: Acute Disease; Animals; Aprotinin; Chronic Disease; Esters; Gabexate; Glycoproteins; Guanidines; Humans; Pancreatitis; Protease Inhibitors; Trypsin Inhibitors | 1991 |
Effects of proteolytic enzyme inhibitors on the nasal absorption of vasopressin and an analogue.
Topics: Administration, Intranasal; Animals; Aprotinin; Biological Availability; Deamino Arginine Vasopressin; Dogs; Esters; Gabexate; Guanidines; Male; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin Inhibitor, Kunitz Soybean; Vasopressins | 1991 |
Mediation of trypsin inhibitor-induced pancreatic hypersecretion by secretin and cholecystokinin in rats.
Topics: Analysis of Variance; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Immune Sera; Least-Squares Analysis; Male; Pancreas; Rabbits; Rats; Rats, Inbred Strains; Secretin; Trypsin Inhibitors | 1992 |
Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Carcinogens; Carcinoma; Carcinoma in Situ; Cholecystokinin; Cricetinae; Esters; Gabexate; Guanidines; Male; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Proglumide; Reference Values; Trypsin Inhibitors | 1991 |
[Effect of protease inhibitor on primary glomerulonephritis and the mechanism of the effect].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Urea Nitrogen; Complement System Proteins; Creatinine; Drug Evaluation; Esters; Female; Fibrinogen; Gabexate; Glomerulonephritis; Granulocytes; Guanidines; Hematuria; Humans; Male; Middle Aged; Pancreatic Elastase; Protease Inhibitors; Proteinuria | 1991 |
The importance of gastric secretion in the feedback control of interdigestive and postprandial pancreatic secretion in rats.
Topics: Animals; Benzodiazepinones; Devazepide; Duodenum; Eating; Esters; Fistula; Gabexate; Gastric Juice; Guanidines; Hydrochloric Acid; Male; Omeprazole; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
[Effect of synthetic protease inhibitor on the oncogenesis of pancreatic cancer in hamsters: study on pancreatic endocrine cells and free radicals].
Topics: Animals; Cricetinae; Esters; Free Radical Scavengers; Free Radicals; Gabexate; Glutathione; Guanidines; Islets of Langerhans; Male; Malondialdehyde; Mesocricetus; Pancreatic Neoplasms; Peroxides; Superoxide Dismutase; Trypsin Inhibitors | 1991 |
[Treatment of peptic ulcer and reflux esophagitis with enzyme inhibitors].
Topics: Adult; Aged; Esophagitis, Peptic; Esters; Female; Gabexate; Gastric Acid; Guanidines; Humans; Omeprazole; Peptic Ulcer; Proton-Translocating ATPases | 1991 |
[Effects of FOY-305 on post-operative reflux esophagitis in rats (I). Effects of FOY-305 on reflux esophagitis after total gastrectomy in rats].
Topics: Alginates; Animals; Body Weight; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Esters; Gabexate; Gastrectomy; Glucuronic Acid; Guanidines; Hexuronic Acids; Male; Postoperative Complications; Rats; Rats, Inbred Strains | 1991 |
[Effect of FOY-305 on post-operative reflux esophagitis in rats (II). Analysis of mechanism in the pathogenesis of reflux esophagitis after total gastrectomy in rats].
Topics: Animals; Bile Acids and Salts; Depression, Chemical; Esophagitis, Peptic; Esophagus; Esters; Gabexate; Gastrectomy; Guanidines; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Trypsin; Trypsin Inhibitors; Tyrosine | 1991 |
Pancreatic microvascular permeability in caerulein-induced acute pancreatitis.
Topics: Acute Disease; Animals; Capillary Permeability; Ceruletide; Edetic Acid; Endothelium, Vascular; Esters; Gabexate; Guanidines; Indicator Dilution Techniques; Insulin; Male; Microcirculation; Pancreas; Pancreatitis; Rats; Rats, Inbred Strains; Serum Albumin | 1991 |
Effects of steroid, retinoid, and protease inhibitors on the formation of acantholysis induced in organ culture of skins from patients with benign familial chronic pemphigus.
Topics: Acantholysis; Adult; Betamethasone; Diterpenes; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Organ Culture Techniques; Pemphigus, Benign Familial; Protease Inhibitors; Retinyl Esters; Skin; Trypsin Inhibitors; Vitamin A | 1991 |
Role of cholecystokinin in cholestyramine-induced changes of the exocrine pancreas.
Topics: Administration, Oral; Animals; Benzodiazepinones; Cholecystokinin; Cholestyramine Resin; Chymotrypsin; Devazepide; Dimethyl Sulfoxide; DNA; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Hypertrophy; Male; Organ Size; Pancreas; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Time Factors; Trypsin; Trypsin Inhibitors | 1991 |
A proteinase inhibitor reduces proteinuria in nephrotic syndrome.
Topics: Esters; Gabexate; Guanidines; Humans; Nephrotic Syndrome; Protease Inhibitors; Proteinuria | 1991 |
[Clinical application of proteinase inhibitors to renal diseases].
Topics: Antithrombins; Esters; Free Radical Scavengers; Gabexate; Guanidines; Humans; Kidney Diseases; Protease Inhibitors; Proteinuria | 1991 |
Elevation of resting fluid secretion precedes trophic responses in the rat pancreas following a single oral administration of Camostat.
Topics: Administration, Oral; Animals; Biological Transport; Cholecystokinin; Electrolytes; Esters; Gabexate; Guanidines; Hypertrophy; Male; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Inbred Strains | 1991 |
Clinical and experimental approaches to the prevention of atherosclerosis by immunological regulations.
Topics: Aged; Animals; Arteriosclerosis; Complement Activation; Complement System Proteins; Dextran Sulfate; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Rabbits | 1990 |
Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. III. Changes in DNA synthesis and mitotic activity.
Topics: Animals; Cholecystokinin; DNA Replication; Esters; Gabexate; Guanidines; Male; Mitosis; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains | 1990 |
Effects of long-term CCK stimulation and CCK blockade on pancreatic and intestinal growth, morphology, and function.
Topics: Animals; Cholecystokinin; Diet; Duodenum; Esters; Gabexate; Guanidines; Intestinal Mucosa; Mice; Mice, Inbred Strains; Pancreas; Proglumide; Protease Inhibitors; Time Factors | 1990 |
Acute and chronic effects of cyclosporine A on pancreatic polyamine metabolism and pancreatic adaptation.
Topics: Acetyltransferases; Adaptation, Physiological; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cholecystokinin; Cyclosporins; Esters; Gabexate; Guanidines; Male; Ornithine Decarboxylase; Pancreas; Rats; Rats, Inbred Strains; Trypsin Inhibitors | 1990 |
Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats.
Topics: Adenoma; Animals; Azaserine; Blotting, Northern; Carcinoma; Cell Cycle; Esters; Gabexate; Gene Expression; Guanidines; Mitotic Index; Pancreas; Pancreatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Rats, Inbred Lew; Regeneration; RNA, Neoplasm | 1990 |
Multiple binding of inhibitors in the complex formed by bovine trypsin and fragments of a synthetic inhibitor, 4-[4-(N,N- dimethylcarbamoxylmethoxycarbonylmethyl)phenoxycarbonylphenyl+ ++] guanidinium methanesulfonate (FOY-305).
Topics: Animals; Cattle; Esters; Gabexate; Guanidines; Protein Conformation; Trypsin; Trypsin Inhibitors; X-Ray Diffraction | 1990 |
Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster.
Topics: Animals; Cholecystokinin; Cricetinae; DNA; Esters; Gabexate; Gelatin; Glutamine; Guanidines; Male; Mesocricetus; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trypsin Inhibitors | 1990 |
Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes.
Topics: Adult; Ceruletide; Cholecystokinin; Dose-Response Relationship, Drug; Duodenum; Esters; Feedback; Gabexate; Gastrointestinal Transit; Guanidines; Humans; In Vitro Techniques; Intestinal Secretions; Intestine, Small; Intubation, Gastrointestinal; Pancreas; Protease Inhibitors; Reference Values; Secretin; Time Factors | 1990 |
Gastric emptying in rats: role of afferent neurons and cholecystokinin.
Topics: Afferent Pathways; Animals; Capsaicin; Eating; Esters; Gabexate; Gastric Emptying; Guanidines; Kinetics; Male; Muscle, Smooth; Neurons; Protease Inhibitors; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sincalide; Stomach; Time Factors | 1990 |
Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis.
Topics: Acute Disease; Animals; Esters; Gabexate; Guanidines; Male; Pancreatitis; Peritoneal Lavage; Protease Inhibitors; Rats; Rats, Inbred Strains; Taurocholic Acid | 1990 |
Effect of camostat mesilate for the treatment of advanced diabetic nephropathy.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Diabetic Nephropathies; Drug Therapy, Combination; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Prognosis; Protease Inhibitors | 1990 |
Gabexate mesilate and camostate: new inhibitors of phospholipase A2 and their influence on the alpha-amylase activity in serum of patients with acute pancreatitis.
Topics: Acute Disease; alpha-Amylases; Aprotinin; Esters; Gabexate; Guanidines; Humans; Infusions, Parenteral; Kinetics; Pancreatitis; Phospholipases; Phospholipases A; Phospholipases A2 | 1985 |
Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. I. Dose-response study on enzyme content and secretion, cholecystokinin release and pancreatic fine structure.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsin; Esters; Gabexate; Golgi Apparatus; Guanidines; Kinetics; Lipase; Male; Microscopy, Electron; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin | 1987 |
Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. II. Regulation of total protein and individual enzyme biosynthesis.
Topics: Amylases; Animals; Chymotrypsinogen; Esters; Gabexate; Guanidines; Kinetics; Lipase; Male; Pancreas; Protease Inhibitors; Protein Biosynthesis; Rats; Rats, Inbred Strains; Trypsinogen | 1987 |
Subcutaneous administration of the synthetic trypsin inhibitor Foy-305 induces hypertrophy of the exocrine pancreas.
Topics: Administration, Oral; Amylases; Animals; Esters; Female; Gabexate; Guanidines; Hypertrophy; Injections, Subcutaneous; Mice; Organ Size; Pancreas; Protease Inhibitors; Stimulation, Chemical; Trypsin | 1987 |
Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsinogen; Esters; Gabexate; Glutamine; Guanidines; Male; Mice; Organ Size; Pancreas; Proglumide; Protease Inhibitors; Sincalide | 1987 |
Effects of camostat, a synthetic protease inhibitor, on endocrine and exocrine pancreas of the rat.
Topics: Amylases; Animals; Body Weight; Chromatography, High Pressure Liquid; Chymotrypsin; Esters; Gabexate; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Lipase; Male; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin | 1988 |
Suppressive effect of camostat mesilate (FOY 305) on acute experimental allergic encephalomyelitis (EAE).
Topics: Animals; Brain; Encephalomyelitis, Autoimmune, Experimental; Esters; Gabexate; Guanidines; Male; Myelin Basic Protein; Protease Inhibitors; Rats; Rats, Inbred Lew | 1988 |
Changes in pattern of enzyme secretion by rat pancreas during repeated trypsin inhibitor treatment.
Topics: Amylases; Animals; Bicarbonates; Esters; Female; Gabexate; Guanidines; Isoenzymes; Kinetics; Lipase; Pancreas; Peptide Hydrolases; Rats; Rats, Inbred Strains; Reference Values; Trypsin Inhibitors | 1988 |
Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis.
Topics: Amylases; Animals; Cathepsin B; Esters; Gabexate; Guanidines; Male; Pancreas; Pancreatitis; Protease Inhibitors; Rats; Rats, Inbred Strains; Vacuoles | 1989 |
In vitro inhibition of phospholipase A2 by gabexate mesilate, camostate, and aprotinine.
Topics: Animals; Aprotinin; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Swine | 1989 |
Effect of a low-molecular weight serine proteinase inhibitor (camostate) on amylase release from isolated pancreatic acini.
Topics: Amylases; Animals; Ceruletide; Cholecystokinin; Esters; Gabexate; Guanidines; In Vitro Techniques; Male; Pancreas; Rats | 1989 |
Effect of atropine on feedback regulation of pancreatic secretion in rats.
Topics: Amylases; Animals; Atropine; Cholecystokinin; Chymotrypsin; Esters; Feedback; Gabexate; Guanidines; Lipase; Male; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors; Trypsin | 1989 |
[The influence of truncal vagotomy or surgical sympathectomy on the pancreatic trophic effect of trypsin inhibitor upon normal rats and major pancreatectomized rats].
Topics: Animals; DNA; Esters; Gabexate; Guanidines; Organ Size; Pancreas; Pancreatectomy; Proteins; Rats; Rats, Inbred Strains; RNA; Sympathectomy; Trypsin Inhibitors; Vagotomy, Truncal | 1989 |
[Study on the trophic effect of camostate mesilate on ethionine-induced pancreatic injury rat].
Topics: Administration, Oral; Amylases; Animals; Cholecystokinin; Esters; Ethionine; Gabexate; Guanidines; In Vitro Techniques; Male; Pancreas; Pancreatic Diseases; Rats; Secretin; Trypsin Inhibitors | 1989 |
Inhibitory effect of reversible serine protease inhibitors on the activity of cytotoxic T lymphocytes.
Topics: Cells, Cultured; Cytotoxicity, Immunologic; Esters; Gabexate; Guanidines; Humans; Kinetics; Protease Inhibitors; Serine Proteinase Inhibitors; T-Lymphocytes, Cytotoxic | 1989 |
Studies on two siblings with recessive dystrophic epidermolysis bullosa (Hallopeau-Siemens) and the plasminogen activator and its inhibitor in the lesion.
Topics: Adolescent; Child; Epidermolysis Bullosa; Esters; Female; Gabexate; Genes, Recessive; Guanidines; HLA Antigens; Humans; Male; Pedigree; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors | 1989 |
Role of ornithine decarboxylase and polyamines in camostate (Foy-305)-induced pancreatic growth in rats.
Topics: Animals; Cholecystokinin; Eflornithine; Esters; Gabexate; Guanidines; Kinetics; Male; Ornithine Decarboxylase; Pancreas; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1989 |
Activation of calcium ion-dependent proteinases by bradykinin in dental pulp of the rat.
Topics: Animals; Bradykinin; Calcium; Calpain; Dental Pulp; Egtazic Acid; Enzyme Activation; Esters; Gabexate; Guanidines; Kinetics; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Effect of FOY-305 (Camostate) on severe acute pancreatitis in two experimental animal models.
Topics: Acute Disease; Animals; Disease Models, Animal; Esters; Gabexate; Guanidines; Pancreatitis; Rats; Rats, Inbred Strains | 1989 |
[A new experimental trial for dissolution of gallbladder stones].
Topics: Animals; Cholelithiasis; Cholesterol; Cricetinae; Deoxycholic Acid; Drug Therapy, Combination; Esters; Gabexate; Guanidines; Mesocricetus; Solubility; Triglycerides; Trypsin Inhibitors; Ursodeoxycholic Acid | 1989 |
Influence of CCK antagonist L-364,718, pancreastatin (33-49) and a somatostatin analogue on camostate-induced rat pancreatic hypertrophy.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Chromogranin A; Devazepide; Esters; Gabexate; Guanidines; Hypertrophy; Male; Octreotide; Pancreas; Pancreatic Hormones; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Cholecystokinin receptor antagonism by peptidergic and non-peptidergic agents in rat pancreas.
Topics: Animals; Benzodiazepinones; Bombesin; Ceruletide; Cholecystokinin; Devazepide; DNA; Esters; Gabexate; Glutamine; Guanidines; Pancreas; Pentagastrin; Proglumide; Protease Inhibitors; Proteins; Rats; Receptors, Cholecystokinin | 1989 |
Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion.
Topics: Adult; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Feedback; Gabexate; Glutamine; Guanidines; Humans; Male; Pancreas; Peptide Hydrolases; Proglumide; Protease Inhibitors; Pulse; Reference Values | 1989 |
Enhancement of proteinase activities by bradykinin in adrenal medulla of the rat.
Topics: Adrenal Medulla; Animals; Bradykinin; Enkephalin, Methionine; Esters; Gabexate; Guanidines; Hydrogen-Ion Concentration; Kinetics; Male; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neoplasms; Precancerous Conditions; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide; Trypsin Inhibitors | 1989 |
Effects of trypsin inhibitor (camostate) on pancreas and CCK release in young and old female rats.
Topics: Aging; Animals; Body Weight; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Female; Gabexate; Guanidines; Intubation, Gastrointestinal; Lipase; Organ Size; Pancreas; Protease Inhibitors; Rats; Rats, Inbred F344; Secretory Rate; Trypsin | 1989 |
Combination therapy of trypsin inhibitor with ursodeoxycholic acid on cholesterol gallbladder stone.
Topics: Cholelithiasis; Cholesterol; Deoxycholic Acid; Drug Therapy, Combination; Esters; Gabexate; Guanidines; Humans; Trypsin Inhibitors; Ursodeoxycholic Acid | 1989 |
Effect of camostat mesilate on heavy proteinuria in various nephropathies.
Topics: Administration, Oral; Adolescent; Adult; Aged; Esters; Female; Gabexate; Glomerulonephritis; Glycosuria, Renal; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Proteinuria | 1989 |
Adaptation of pancreatic amino acid transport in rats after treatment with the synthetic protease inhibitor camostat mesilate.
Topics: Administration, Oral; Amino Acids; Animals; Esters; Gabexate; Guanidines; Male; Pancreas; Phenylalanine; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Anti-carcinogenic effects of a serine protease inhibitor (FOY-305) through the suppression of neutral serine protease activity during chemical hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride; Endopeptidases; Esters; Gabexate; gamma-Glutamyltransferase; Guanidines; Liver; Liver Neoplasms, Experimental; Male; Protease Inhibitors; Rats; Rats, Inbred Strains; Serine Endopeptidases | 1987 |
Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models.
Topics: Acute Disease; Animals; Choline Deficiency; Esters; Female; Gabexate; Guanidines; Male; Mice; Pancreatitis; Protease Inhibitors; Rats; Rats, Inbred Strains; Taurocholic Acid | 1989 |
Inhibition by FOY of kininase II in human plasma.
Topics: Angiotensin-Converting Enzyme Inhibitors; Chlorides; Enzyme Stability; Esters; Gabexate; Guanidines; Humans; Kinetics; Peptidyl-Dipeptidase A; Zinc; Zinc Compounds | 1986 |
In vivo effects of camostat mesilate on plasma kallikrein, plasma kininase II and renal kallikrein of man.
Topics: Adult; Esters; Factor XII; Female; Gabexate; Guanidines; Humans; Kallikreins; Kidney; Male; Peptidyl-Dipeptidase A | 1987 |
Action of the cholecystokinin antagonist L364,718 on gastric emptying in the rat.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Esters; Gabexate; Gastric Emptying; Guanidines; Male; Peptide Hydrolases; Peptones; Rats; Rats, Inbred Strains; Sincalide | 1988 |
Stimulation of pancreatic secretion in man by a protease inhibitor (camostate).
Topics: Cholecystokinin; Dietary Carbohydrates; Dietary Proteins; Esters; Feedback; Gabexate; Guanidines; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Pancreas; Protease Inhibitors; Radioimmunoassay; Secretin; Trypsin | 1988 |
Synthetic versus natural protease inhibitors in acute experimental pancreatitis.
Topics: Animals; Esters; Gabexate; Guanidines; Male; Pancreatitis; Plasma; Protease Inhibitors; Rats | 1988 |
Increased CCK-response to proteinase inhibitor feeding after induction of pancreatic hypertrophy in rats.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Female; Gabexate; Guanidines; Hypertrophy; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
Proglumide antagonizes cholecystokinin effects on plasma glucose and insulin in rats in vivo.
Topics: Animals; Blood Glucose; Cholecystokinin; Esters; Female; Gabexate; Glucose Tolerance Test; Glutamine; Guanidines; Insulin Antagonists; Male; Proglumide; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
Pancreatic and biliary excretion of camostat in dogs.
Topics: Animals; Bile; Ceruletide; Dogs; Esters; Gabexate; Guanidines; Metabolic Clearance Rate; Pancreatic Juice; Secretin; Secretory Rate | 1988 |
Intestinal absorption of N,N'-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy) phenylacetate methanesulfonate in rats.
Topics: Animals; Esters; Gabexate; Guanidines; Intestinal Absorption; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
Enhancement of small intestinal absorption of N,N'-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy) phenylacetate methanesulfonate (FOY305) in rats.
Topics: Animals; Esters; Gabexate; Guanidines; Intestinal Absorption; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
[Inhibitors of serine proteinase inhibit epidermal cell migration (epiboly)].
Topics: Animals; Cell Movement; Depression, Chemical; Epidermal Cells; Esters; Gabexate; Guanidines; Mice; Organ Culture Techniques; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors | 1988 |
Effect of camostat mesilate on puromycin aminonucleoside nephrotic rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Esters; Gabexate; Guanidines; Male; Nephrosis; Protease Inhibitors; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thromboxane B2 | 1988 |
Ornithine decarboxylase and polyamine biosynthesis in pancreatic adaptation.
Topics: Animals; Chromatography, High Pressure Liquid; Esters; Gabexate; Guanidines; In Vitro Techniques; Male; Organ Size; Ornithine Decarboxylase; Pancreas; Polyamines; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Stimulation of the growth of azaserine-induced nodules in the rat pancreas by dietary camostate (FOY-305).
Topics: Animals; Azaserine; Carcinogens; Cell Division; Diet; Esters; Gabexate; Guanidines; Pancreas; Pancreatic Neoplasms; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Lew | 1988 |
Neutral protease in cerebrospinal fluid from patients with multiple sclerosis and other neurological diseases.
Topics: Amyotrophic Lateral Sclerosis; Endopeptidases; Esters; Follow-Up Studies; Gabexate; Guanidines; Humans; Meningoencephalitis; Multiple Sclerosis; Neprilysin; Nervous System Diseases; Protease Inhibitors; Psychophysiologic Disorders | 1987 |
Effects of L-364,718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Esters; Gabexate; Guanidines; Hypertrophy; Male; Organ Size; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
Protease inhibitor therapy for recessive dystrophic epidermolysis bullosa. In vitro effect and clinical trial with camostat mesylate.
Topics: Administration, Topical; Adolescent; Adult; Blister; Child; Epidermolysis Bullosa; Esters; Female; Gabexate; Genes, Recessive; Guanidines; Humans; Male; Organ Culture Techniques; Protease Inhibitors; Skin | 1988 |
Elimination of the low-molecular weight proteinase inhibitor camostate (FOY 305) and its degradation products by the rat liver.
Topics: Administration, Oral; Animals; Benzoates; Biotransformation; Esters; Female; Gabexate; Guanidines; In Vitro Techniques; Liver; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains | 1987 |
New approach to management of chronic vascular rejection with prostacyclin analogue after kidney transplantation.
Topics: alpha-Cyclodextrins; Benzamidines; Blood Platelets; Cyclodextrins; Epoprostenol; Esters; Gabexate; Graft Rejection; Guanidines; Humans; Kidney; Kidney Transplantation; Vascular Diseases | 1987 |
Endogenous CCK release and pancreatic growth in rats after feeding a proteinase inhibitor (camostate).
Topics: Animals; Cholecystokinin; Esters; Female; Gabexate; Guanidines; Pancreas; Pancreatic Juice; Proglumide; Protease Inhibitors; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors | 1986 |
Effect of synthetic trypsin inhibitor on plasma immunoreactive cholecystokinin in rats.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Duodenum; Esters; Gabexate; Guanidines; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Secretin; Trypsin Inhibitors | 1987 |
Effect of synthetic protease inhibitor camostate on pancreatic exocrine function in rats.
Topics: Animals; Esters; Gabexate; Guanidines; Male; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Inbred Strains | 1987 |
[Protective effect of camostat mesilate and allopurinol in acute edematous pancreatitis in the rat induced by excessive doses of caerulein].
Topics: Acute Disease; Allopurinol; Animals; Ceruletide; Edema; Esters; Gabexate; Guanidines; Male; Pancreatitis; Rats; Rats, Inbred Strains; Trypsin Inhibitors | 1987 |
[Effect of a specific serine protease inhibitor on the rat pancreas. II. Influence of camostate on the endocrine pancreas].
Topics: Administration, Oral; Animals; Body Weight; Esters; Gabexate; Guanidines; Hypertrophy; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains | 1985 |
Influence of a low molecular weight serine proteinase inhibitor (camostate) on lipolysis of isolated adipocytes.
Topics: Adipose Tissue; Animals; Esters; Gabexate; Guanidines; Lipolysis; Male; Rats; Rats, Inbred Strains; Shock | 1985 |
Effect of short-term peroral administration of synthetic trypsin inhibitor on endocrine secretion in the isolated perfused rat pancreas.
Topics: Amylases; Animals; Arginine; Ceruletide; Esters; Gabexate; Glucagon; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Male; Organ Size; Protease Inhibitors; Proteins; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Characteristic secretory response of the exocrine pancreas in various mammalian and avian species.
Topics: Amylases; Animals; Chickens; Cholecystokinin; Chymotrypsin; Ducks; Electric Stimulation; Esters; Gabexate; Guanidines; Male; Mink; Pancreas; Pancreatic Juice; Rabbits; Rats; Rats, Inbred Strains; Sheep; Swine; Trypsin; Trypsin Inhibitors; Vagus Nerve | 1982 |
Inhibition of phospholipase A2 by gabexate mesilate, camostate and aprotinine.
Topics: Animals; Aprotinin; Esters; Gabexate; Guanidines; Kinetics; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Protease Inhibitors; Swine | 1983 |
General and selective inhibition of pancreatic enzyme discharge using a proteinase inhibitor (FOY-305).
Topics: Amylases; Animals; Carboxypeptidases; Carboxypeptidases A; Chymotrypsinogen; Enzyme Precursors; Esters; Gabexate; Guanidines; Lipase; Male; Pancreas; Pancreatic Elastase; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsinogen | 1984 |
[Effect of FOY-305 on the activity and secretion of pancreatic enzymes in vitro].
Topics: Amylases; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Humans; Male; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin | 1984 |
Decreased pancreatic CCK receptor binding and CCK-stimulated amylase release in Zucker obese rats.
Topics: Amylases; Animals; Body Weight; Carbachol; Culture Techniques; DNA; Dose-Response Relationship, Drug; Esters; Female; Gabexate; Guanidines; Pancreas; Peptide Fragments; Rats; Rats, Zucker; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide | 1984 |
Effect of a specific serine protease inhibitor on the rat pancreas: systemic administration of camostate and exocrine pancreatic secretion.
Topics: Amylases; Animals; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Male; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin | 1984 |
Changes of the Met-enkephalin-like peptide content induced by noxious stimuli in the rat incisor pulp.
Topics: Animals; Captopril; Cycloheximide; Dental Caries; Dental Pulp; Dogs; Enkephalin, Methionine; Esters; Gabexate; Guanidines; Guinea Pigs; Incisor; Protease Inhibitors; Rats | 1983 |
Effect of a protease inhibitor [N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate on the growth of mouse skin carcinoma in the rapid growing stage.
Topics: Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Division; Esters; Female; Gabexate; Guanidines; Methylcholanthrene; Mice; Protease Inhibitors; Skin Neoplasms | 1984 |
[The effect of oral synthetic protease inhibitor (FOY 305) on endocrine pancreas and carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats].
Topics: Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Esters; Gabexate; Glucagon; Guanidines; Insulin; Islets of Langerhans; Lipid Metabolism; Liver; Organ Size; Protease Inhibitors; Rats; Rats, Inbred Strains | 1984 |
Effects of trypsin inhibitor on the remnant pancreas after 85 percent pancreatectomy in rats.
Topics: 4-Aminobenzoic Acid; Animals; Blood Glucose; Body Weight; Esters; Gabexate; Guanidines; Insulin; Islets of Langerhans; Male; Organ Size; Pancreas; Pancreatectomy; Protease Inhibitors; Rats; Rats, Inbred Strains; Trypsin Inhibitors | 1984 |
Effects of the serine protease inhibitors FOY and FOY 305 on phospholipase A1 (EC 3.1.1.32) activity in rat - liver lysosomes.
Topics: Animals; Esters; Gabexate; Guanidines; In Vitro Techniques; Liver; Lysosomes; Phosphatidylethanolamines; Phospholipases; Phospholipases A; Phospholipases A1; Protease Inhibitors; Rats | 1983 |
Discrepancy between the potency of various trypsin inhibitors to inhibit trypsin activity and the potency to release biologically active cholecystokinin-pancreozymin.
Topics: Animals; Benzamidines; Cholecystokinin; Duodenum; Esters; Gabexate; Guanidines; Male; Pancreas; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trypsin Inhibitors | 1984 |
Effect of the synthetic protease inhibitor [N,N-dimethylcarbamoyl-methyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate on carcinogenesis by 3-methylcholanthrene in mouse skin.
Topics: Animals; Carcinoma, Squamous Cell; Diet; Esters; Female; Gabexate; Guanidines; Methylcholanthrene; Mice; Mice, Inbred Strains; Probability; Protease Inhibitors; Skin Neoplasms; Time Factors | 1983 |
Clinical experience with a protease inhibitor [N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate for prevention of recurrence of carcinoma of the mouth and in treatment of terminal carcinoma.
Topics: Adult; Carcinoma, Squamous Cell; Esters; Evaluation Studies as Topic; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Mouth Neoplasms; Neoplasm Recurrence, Local; Protease Inhibitors | 1984 |
Secretory responses of hypertrophied rat pancreas induced by repeated oral administrations of a synthetic protease inhibitor.
Topics: Acetylcholine; Administration, Oral; Animals; Cholecystokinin; Esters; Gabexate; Guanidines; Hypertrophy; In Vitro Techniques; Male; Pancreas; Protease Inhibitors; Rats; Rats, Inbred Strains | 1983 |
Effect of oral administration of protease inhibitor [N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate on the growth of 3-methylcholanthrene-induced carcinoma in mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Esters; Female; Gabexate; Guanidines; Methylcholanthrene; Mice; Neoplasms, Experimental; Protease Inhibitors; Skin Neoplasms | 1982 |
Inhibition of growth of 3-methylcholanthrene-induced mouse skin tumor by protease inhibitor [N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetate] methanesulfate.
Topics: Animals; Body Weight; Carcinoma, Squamous Cell; Cell Division; Drug Evaluation, Preclinical; Esters; Female; Gabexate; Guanidines; Methylcholanthrene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Protease Inhibitors; Skin Neoplasms | 1981 |
Endocrine and exocrine pancreatic function after camostate-induced growth of the organ.
Topics: Animals; Blood Glucose; Cholecystokinin; Esters; Gabexate; Glucagon; Guanidines; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Protease Inhibitors; Protein Biosynthesis; Rats; Rats, Wistar | 1995 |
Effect of camostate administration for two weeks on experimental pancreatitis in mice and rats.
Topics: Administration, Oral; Amylases; Animals; Cholecystokinin; Esters; Female; Gabexate; Guanidines; Male; Mice; Pancreas; Pancreatitis; Protease Inhibitors; Rats; Rats, Wistar | 1993 |
An experimental study on the effects of selected drugs on pancreatic regeneration after partial pancreatectomy.
Topics: Amylases; Animals; Body Weight; Ceruletide; DNA; Esters; Gabexate; Guanidines; Hydrocortisone; Male; Pancreas; Pancreatectomy; Proteins; Rats; Rats, Wistar; Regeneration; Thymidine; Trypsin Inhibitors | 1993 |
Differential effects of proteinase inhibitor camostat on exocrine pancreas in fed and fasted rats.
Topics: Administration, Oral; Amylases; Animals; Cholecystokinin; Duodenum; Eating; Esters; Fasting; Gabexate; Guanidines; Injections; Male; Organ Size; Pancreas; Protease Inhibitors; Proteins; Rats; Rats, Wistar; Secretin; Time Factors | 1993 |
[Inhibitory effects of sepimostat mesilate (FUT-187) on the activities of trypsin-like serine proteases in vitro].
Topics: Animals; Blood Coagulation; Esters; Gabexate; Guanidines; Guinea Pigs; Hemolysis; Humans; Imidazoles; In Vitro Techniques; Male; Rabbits; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Trypsin Inhibitors | 1995 |
Beneficial effects of preventive oral administration of camostate on cerulein-induced pancreatitis in rats.
Topics: Administration, Oral; Animals; Ceruletide; Esters; Gabexate; Guanidines; Pancreatitis; Rats; Rats, Wistar; Trypsin; Trypsin Inhibitors | 1995 |
Hormonal regulation of protein disulfide isomerase and chaperone synthesis in the rat exocrine pancreas.
Topics: Amino Acid Sequence; Animals; Calcium-Binding Proteins; Calreticulin; Carrier Proteins; Cell Line, Transformed; Ceruletide; Chaperonins; Dexamethasone; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Esters; Gabexate; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hot Temperature; Isomerases; Male; Molecular Chaperones; Molecular Sequence Data; Pancreas; Protease Inhibitors; Protein Biosynthesis; Protein Disulfide-Isomerases; Protein Folding; Proteins; Rats; Rats, Wistar; Ribonucleoproteins; RNA, Messenger | 1994 |
Gastrin-releasing peptide and CCK after intraduodenal inhibition of proteases in dogs.
Topics: Animals; Cholecystokinin; Dogs; Esters; Feedback; Gabexate; Gastrin-Releasing Peptide; Guanidines; Pancreas; Peptides; Protease Inhibitors | 1994 |
Effect of bile salt binding or protease inactivation on plasma cholecystokinin and gallbladder responses to bombesin.
Topics: Adult; Bile Acids and Salts; Bombesin; Cholecystokinin; Cholestyramine Resin; Colestipol; Endopeptidases; Enzyme Activation; Esters; Feedback; Female; Gabexate; Gallbladder; Gastrins; Guanidines; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Protein Binding | 1994 |
Alcohol does not affect the trophic pancreatic effect of CCK and its plasma level in young rats.
Topics: Animals; Cholecystokinin; Esters; Ethanol; Gabexate; Guanidines; Hypertrophy; Male; Pancreas; Rats; Rats, Wistar | 1994 |
Brefeldin A induced dose-dependent changes to Golgi structure and function in the rat exocrine pancreas.
Topics: Animals; Brefeldin A; Clathrin; Coatomer Protein; Cyclopentanes; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Esters; Exocytosis; Gabexate; Golgi Apparatus; Guanidines; Male; Membrane Fusion; Microtubule-Associated Proteins; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Wistar | 1994 |
Endogenous somatostatin possibly controls pancreatic growth: further evidence for feedback regulation.
Topics: Animals; Esters; Feedback; Gabexate; Guanidines; Male; Organ Size; Pancreas; Protease Inhibitors; Rats; Rats, Wistar; Somatostatin | 1993 |
Blocking effects of synthetic trypsin inhibitor (camostat) on pancreatic carcinogenesis in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Topics: Adenocarcinoma; Animals; Carcinogens; Cricetinae; Esters; Female; Gabexate; Guanidines; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms | 1994 |
Metabolic fate of 14C-camostat mesylate in man, rat and dog after intravenous administration.
Topics: Adult; Animals; Benzoates; Biotransformation; Blood Proteins; Carbon Radioisotopes; Dogs; Esters; Gabexate; Guanidines; Humans; Infusions, Intravenous; Male; Protease Inhibitors; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution; Trypsin Inhibitors | 1994 |
Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1.
Topics: Animals; Bombesin; Bucladesine; Calcimycin; Cholecystokinin; Colforsin; Cyclic AMP; Diterpenes; Dose-Response Relationship, Drug; Esters; Fatty Alcohols; Gabexate; Gene Expression; Guanidines; Mice; Tumor Cells, Cultured | 1994 |
Gastrin-releasing peptide and CCK after intraduodenal inhibition of proteases.
Topics: Animals; Cholecystokinin; Dogs; Duodenum; Esters; Fistula; Gabexate; Gastrin-Releasing Peptide; Gastrins; Guanidines; Immunoglobulins; Infusions, Intravenous; Pancreas; Peptides; Protease Inhibitors; Proteins | 1994 |
Effect of synthetic protease inhibitor on histologic changes and free radical activity in hamsters with pancreatic cancer.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Carcinogens; Cricetinae; Esters; Free Radical Scavengers; Gabexate; Glutathione Peroxidase; Guanidines; Male; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Superoxide Dismutase; Trypsin Inhibitors | 1993 |
Importance of various intracellular regulatory mechanisms of polyamine metabolism in camostate-induced pancreatic growth in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Biogenic Polyamines; Eflornithine; Esters; Gabexate; Guanidines; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Putrescine; Rats; Rats, Wistar; Time Factors; Trypsin Inhibitors | 1993 |
Loxiglumide (CR1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice.
Topics: Animals; Cell Division; Chloroquine; Cholecystokinin; DNA; Esters; Gabexate; Guanidines; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organ Culture Techniques; Pancreatic Neoplasms; Proglumide; Sincalide; Transplantation, Heterologous | 1993 |
The effect of endogenous cholecystokinin released by bombesin and trypsin inhibitor on the regeneration of the pancreas.
Topics: Animals; Benzodiazepinones; Bombesin; Cholecystokinin; Devazepide; Esters; Gabexate; Guanidines; Male; Pancreas; Rats; Rats, Inbred F344; Regeneration; Time Factors; Trypsin Inhibitors | 1993 |
Feedback regulation of exocrine pancreatic secretion in dogs.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Duodenum; Esters; Feedback; Food; Gabexate; Guanidines; Homeostasis; Kinetics; Lipase; Pancreas; Protease Inhibitors | 1993 |
Comparative inhibitory effects of various nucleoside and nonnucleoside analogues on replication of influenza virus types A and B in vitro and in ovo.
Topics: Adenosine; Animals; Antiviral Agents; Benzamidines; Cells, Cultured; Chick Embryo; Dextran Sulfate; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Guanosine; Influenza A virus; Influenza B virus; Nucleosides; Protease Inhibitors; Ribavirin; Virus Replication | 1993 |
Treatment of ulcerative colitis with camostat mesilate, a serine protease inhibitor.
Topics: Adult; Colitis, Ulcerative; Esters; Gabexate; Guanidines; Humans; Male; Serine Proteinase Inhibitors | 1993 |
The effect of trypsin inhibitor on the pancreas and small intestine of mice.
Topics: Animals; Body Weight; Duodenum; Esters; Gabexate; Glycine max; Guanidines; Intestine, Small; Male; Mice; Organ Size; Pancreas; Proteins; Rats; Rats, Wistar; Trypsin Inhibitors | 1993 |
Chronic effects of camostate on growth and endocrine function of the pancreas in streptozotocin-induced diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Esters; Gabexate; Guanidines; Hyperplasia; Hypertrophy; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Wistar; Time Factors | 1993 |
Physiological characteristics of spontaneously developed diabetes in male WBN/Kob rat and prevention of development of diabetes by chronic oral administration of synthetic trypsin inhibitor (FOY-305).
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Esters; Gabexate; Glucose Tolerance Test; Guanidines; Insulin; Male; Organ Size; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Time Factors; Trypsin Inhibitors | 1993 |
Chronic oral administration of synthetic trypsin inhibitor camostate reduces amylase release from isolated rat pancreatic acini.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Administration, Oral; Amylases; Animals; Calcimycin; Carbachol; Cholecystokinin; Esters; Gabexate; Guanidines; In Vitro Techniques; Male; Pancreas; Rats; Rats, Wistar; Secretin; Sincalide; Tetradecanoylphorbol Acetate; Trypsin Inhibitors | 1995 |
Okadaic acid disrupts Golgi structure and impairs enzyme synthesis and secretion in the rat pancreas.
Topics: Animals; Cholecystokinin; Enzymes; Esters; Ethers, Cyclic; Gabexate; Golgi Apparatus; Guanidines; Male; Microscopy, Electron; Okadaic Acid; Pancreas; Protease Inhibitors; Protein Biosynthesis; Rats; Rats, Wistar | 1996 |
Effect of oral administration of protease inhibitor on pancreatic exocrine function in WBN/Kob rats with chronic pancreatitis.
Topics: Administration, Oral; Animals; Cholecystokinin; Chronic Disease; Disease Models, Animal; Esters; Gabexate; Guanidines; Humans; Male; Pancreas; Pancreatitis; Protease Inhibitors; Rats; Rats, Inbred Strains; Rats, Wistar | 1996 |
Camostate- and caerulein-induced delay of gastric emptying in the rat: effect of CCK receptor antagonists.
Topics: Analysis of Variance; Animals; Benzodiazepinones; Ceruletide; Devazepide; Dose-Response Relationship, Drug; Esters; Gabexate; Gastric Emptying; Gastrointestinal Agents; Guanidines; Hormone Antagonists; Male; Phenylurea Compounds; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 1996 |
Reduction by a kallikrein inhibitor of the increased nasal airway resistance of allergic patients after antigen challenge.
Topics: Airway Resistance; Allergens; Animals; Antigens; Esters; Gabexate; Guanidines; Humans; Kallikreins; Mites; Nasal Mucosa; Rhinitis, Allergic, Perennial; Serine Proteinase Inhibitors | 1996 |
Age-dependent influence of octreotide on stimulated pancreatic growth in the postnatal period of rats.
Topics: Analysis of Variance; Animals; Ceruletide; Esters; Female; Gabexate; Gastrointestinal Agents; Growth Hormone; Guanidines; Male; Octreotide; Pancreas; Protease Inhibitors; Rats; Rats, Wistar; Sincalide | 1996 |
Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses.
Topics: Adaptation, Physiological; Amantadine; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Dogs; Drug Evaluation; Esters; Female; Gabexate; Guanidines; Influenza A virus; Influenza B virus; Lung; Mice; Mice, Inbred ICR; Nasal Lavage Fluid; Oropharynx; Orthomyxoviridae Infections | 1996 |
An inhibition of urinary albumin excretion by protease inhibitor in streptozotocin-diabetic rats.
Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eating; Esters; Gabexate; Guanidines; Kidney; Male; Organ Size; Rats; Rats, Wistar; Streptozocin; Trypsin Inhibitors | 1996 |
Rat pancreas after long-term treatment with the somatostatin analogue octreotide.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Male; Octreotide; Organ Size; Pancreas; Rats; Rats, Wistar; Time Factors | 1995 |
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cathepsin B; Colonic Neoplasms; Dimethylhydrazines; Esters; Gabexate; Guanidines; Leupeptins; Male; Protease Inhibitors; Rats | 1996 |
The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats.
Topics: Amylases; Animals; Benzodiazepinones; Cholagogues and Choleretics; Devazepide; Esters; Gabexate; Guanidines; Histocytochemistry; Hormone Antagonists; Male; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Taurocholic Acid; Trypsin Inhibitors | 1996 |
Accelerated gastric emptying of glucose in Zucker type 2 diabetic rats: role in postprandial hyperglycaemia.
Topics: Animals; Cholecystokinin; Diabetes Mellitus, Type 2; Esters; Gabexate; Gastric Emptying; Glucose; Guanidines; Hyperglycemia; Male; Postprandial Period; Rats; Rats, Zucker; Secretin; Trypsin Inhibitors | 1997 |
Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon.
Topics: Animals; Aprotinin; Calcitonin; Cecum; Endopeptidases; Esters; Gabexate; Guanidines; Hydrogen-Ion Concentration; Insulin; Male; Protease Inhibitors; Rats; Rats, Wistar | 1997 |
Uptake of extracellular, dietary putrescine is an important regulatory mechanism of intracellular polyamine metabolism during camostate-induced pancreatic growth in rats.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Esters; Gabexate; Guanidines; Intestine, Small; Liver; Male; Ornithine Decarboxylase Inhibitors; Pancreas; Polyamines; Putrescine; Random Allocation; Rats; Time Factors; Tritium; Trypsin Inhibitors | 1997 |
Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Disease Models, Animal; Dogs; Esters; Female; Gabexate; Guanidines; Hormone Antagonists; Indoles; Ligation; Male; Pancreatic Ducts; Pancreatitis; Proglumide; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 1997 |
Effect of oral protease inhibitor administration on gallbladder motility in patients with mild chronic pancreatitis.
Topics: Administration, Oral; Adult; Aged; Cholecystokinin; Chronic Disease; Esters; Female; Gabexate; Gallbladder; Guanidines; Humans; Male; Middle Aged; Pancreatitis; Protease Inhibitors | 1997 |
Importance of intracellular S-adenosylmethionine decarboxylase activity for the regulation of camostate-induced pancreatic polyamine metabolism and growth: in vivo effect of two novel S-adenosylmethionine decarboxylase inhibitors.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Deoxyadenosines; Enzyme Inhibitors; Esters; Gabexate; Guanidines; Indans; Intracellular Fluid; Liver; Male; Pancreas; Polyamines; Random Allocation; Rats; Rats, Wistar | 1997 |
Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.
Topics: Animals; Atropine; Cholecystokinin; Duodenum; Esters; Gabexate; Glycyrrhizic Acid; Guanidines; Japan; Male; Pancreas; Pancreatic Juice; Plant Extracts; Plant Roots; Plants, Medicinal; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Saponins; Triterpenes; Trypsin; Trypsin Inhibitors | 1997 |
CCK-, secretin-, and cholinergic-independent pancreatic fluid hypersecretion in protease inhibitor-treated rats.
Topics: Acetylcholine; Allylglycine; Animals; Benzamidines; Bicarbonates; Cell Division; Chlorides; Cholecystokinin; Esters; Gabexate; Guanidines; Male; Pancreas; Protease Inhibitors; Rats; Rats, Wistar; Secretin; Serine Proteinase Inhibitors | 1998 |
Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct.
Topics: Amylases; Animals; Blood Glucose; Body Weight; Chronic Disease; Disease Models, Animal; Esters; Gabexate; Guanidines; Linoleic Acid; Male; Oleic Acid; Organ Size; Pancreas; Pancreatic Ducts; Pancreatitis; Protease Inhibitors; Rats; Rats, Wistar; Solutions; Survival Rate; Zein | 1998 |
Effect of methylcarbonylmethyl 2(S)-[4-(4-guanidino-benzoyloxy)phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats.
Topics: Amylases; Animals; Ceruletide; Disease Models, Animal; Esters; Gabexate; Guanidines; Male; Pancreatitis; Propionates; Rats; Rats, Wistar; Taurocholic Acid; Trypsin; Trypsin Inhibitors | 1998 |
Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.
Topics: Allylglycine; Benzamidines; Cell Survival; Drug Screening Assays, Antitumor; Esters; Gabexate; Guanidines; Humans; Neuroblastoma; Protease Inhibitors; Serine Proteinase Inhibitors; Tumor Cells, Cultured | 1998 |
Different actions of CCK on pancreatic and gastric growth in the rat: effect of CCK(A) receptor blockade.
Topics: Animals; Ceruletide; Cholecystokinin; DNA; Esters; Gabexate; Gastric Mucosa; Guanidines; Male; Organ Size; Pancreas; Pentanoic Acids; Protease Inhibitors; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Stomach | 1998 |
Adaptation of the human pancreas to inhibition of luminal proteolytic activity.
Topics: Adaptation, Physiological; Adult; Amylases; Bicarbonates; Ceruletide; Cholecystokinin; Duodenum; Esters; Female; Food; Gabexate; Guanidines; Humans; Islets of Langerhans; Lipase; Male; Pancreas; Protease Inhibitors; Secretin; Trypsin; Ultrasonography | 1998 |
A protease inhibitor attenuates gastric erosions and microcirculatory disturbance in the early period after thermal injury in rats.
Topics: Animals; Burns; Esters; Free Radicals; Gabexate; Gastric Mucosa; Guanidines; Leukocytes; Male; Microcirculation; Protease Inhibitors; Rats; Rats, Wistar; Stomach | 1998 |
Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats.
Topics: Animals; Aprotinin; Bacitracin; Calcitonin; Calcium; Colon; Esters; Gabexate; Guanidines; Humans; Hydrolysis; Ileum; Intestinal Absorption; Jejunum; Male; Protease Inhibitors; Rats; Rats, Wistar; Trypsin Inhibitor, Kunitz Soybean | 1998 |
Effect of methylcarbonylmethyl 2(S)-[4-(4-guanidinobenzoyloxy) phenyl] propionate methanesulfonate (TT-S24) on pancreatic secretion in rats.
Topics: Acetylcholine; Amylases; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Esters; Gabexate; Guanidines; Injections, Intravenous; Male; Pancreas; Pancreatic Juice; Propionates; Rats; Rats, Wistar; Trypsin Inhibitors; Vasodilator Agents | 1998 |
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Topics: Animals; Cholecystokinin; DNA Replication; Dopamine Agents; Esters; Gabexate; Gastric Mucosa; Gastrins; Guanidines; Hormone Antagonists; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pancreatin; Proglumide; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regional Blood Flow; RNA, Messenger; Sensory Receptor Cells; Sincalide; Somatostatin; Stomach; Stomach Ulcer | 1999 |
Oral administration of sepimostat mesilate prevents acute alcohol pancreatic injury in rats.
Topics: Acute Disease; Administration, Oral; Amylases; Animals; Ceruletide; Esters; Ethanol; Gabexate; Guanidines; Imidazoles; Lipase; Male; Pancreas; Pancreatitis; Protease Inhibitors; Rats; Rats, Wistar | 1999 |
Stimulative effect of a casein hydrolysate on exocrine pancreatic secretion that is independent of luminal trypsin inhibitory activity in rats.
Topics: Adolescent; Animals; Bile; Caseins; Dose-Response Relationship, Drug; Duodenum; Esters; Gabexate; Guanidines; Humans; Male; Pancreas; Pancreatic Juice; Protease Inhibitors; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Trypsin Inhibitors | 1999 |
Effect of trypsin inhibitor on reflux oesophagitis after total gastrectomy in rats.
Topics: Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Division; Esophagitis, Peptic; Esters; Gabexate; Gastrectomy; Guanidines; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Trypsin Inhibitors | 1999 |
Different effects of trypsin inhibitors on intestinal gene expression of secretin and on pancreatic bicarbonate secretion in CCK-A-receptor-deficient rats.
Topics: Allylglycine; Animals; Benzamidines; Bicarbonates; Blotting, Northern; Body Weight; Cholecystokinin; Eating; Esters; Gabexate; Gene Expression Regulation; Guanidines; Intestinal Mucosa; Intestines; Pancreas; Pancreatic Juice; Rats; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; RNA, Messenger; Secretin; Trypsin Inhibitor, Kunitz Soybean; Trypsin Inhibitors | 1999 |
Regulation of the initiation of pancreatic digestive enzyme protein synthesis by cholecystokinin in rat pancreas in vivo.
Topics: Animals; Carrier Proteins; Cholecystokinin; Digestion; Enzymes; Esters; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Gabexate; Guanidines; Intracellular Signaling Peptides and Proteins; Male; Pancreas; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Trypsin Inhibitors | 2000 |
Does increased endogenous CCK interact with serotonin to reduce food intake in rats?
Topics: Animals; Anorexia; Body Weight; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Eating; Esters; Fenfluramine; Gabexate; Guanidines; Male; Protease Inhibitors; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors; Trypsin Inhibitors | 2000 |
[Effective use of camostat mesilate for chronic disseminated intravascular coagulation complicated by thoracoabdominal aortic aneurysm].
Topics: Administration, Oral; Aged; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Chronic Disease; Disseminated Intravascular Coagulation; Esters; Gabexate; Guanidines; Humans; Male; Protease Inhibitors | 2001 |
Preparation and characterization of biodegradable or enteric-coated microspheres containing the protease inhibitor camostat.
Topics: Buffers; Chromatography, High Pressure Liquid; Drug Compounding; Esters; Excipients; Gabexate; Guanidines; Hydrogen-Ion Concentration; Lactic Acid; Microspheres; Polyesters; Polymers; Protease Inhibitors; Tablets, Enteric-Coated | 2001 |
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells.
Topics: Cell Division; Cells, Cultured; Collagen; Esters; Fibroblasts; Gabexate; Guanidines; Humans; Pancreas; Platelet-Derived Growth Factor; Proline; Serine Proteinase Inhibitors; Thymidine; Transforming Growth Factor beta; Tritium | 2001 |
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta.
Topics: Animals; Cells, Cultured; Esters; Fibrinolysin; Gabexate; Guanidines; Liver Cirrhosis, Experimental; Male; Protease Inhibitors; Rats; Rats, Wistar; Transcriptional Activation; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator | 2001 |
Effect of camostat mesilate on the expression of pancreatitis-associated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis.
Topics: Acute-Phase Proteins; Animals; Antigens, Neoplasm; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Esters; Gabexate; Gene Expression; Growth Substances; Guanidines; Interleukin-6; Lectins, C-Type; Male; Neoplasm Proteins; Pancreatitis; Pancreatitis-Associated Proteins; Rats; Transforming Growth Factor beta | 2001 |
Novel trial for the treatment of steroid dependency in minimal change disease: combined therapy of camostat mesilate and glycyrrhizin.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therapy, Combination; Esters; Female; Gabexate; Glycyrrhizic Acid; Guanidines; Humans; Male; Nephrosis, Lipoid; Prednisolone; Protease Inhibitors | 2002 |
Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.
Topics: Animals; Blood Pressure; Endopeptidases; Esters; Gabexate; Guanidines; Humans; In Vitro Techniques; Inflammation; Intestinal Mucosa; Intestines; Leukocytes; Male; Multiple Organ Failure; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Phospholipases A; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion; Serine Endopeptidases; Serine Proteinase Inhibitors; Shock; Splanchnic Circulation; Survival Rate | 2002 |
[Thoracic aortic aneurysm with chronic disseminated intravascular coagulation treated successfully with orally administered camostat mesilate, warfarin and aspirin].
Topics: Administration, Oral; Aged; Anticoagulants; Aortic Aneurysm, Thoracic; Aspirin; Chronic Disease; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Esters; Gabexate; Guanidines; Humans; Male; Warfarin | 2002 |
Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice.
Topics: Administration, Oral; alpha-Amylases; Animals; Esters; Female; Gabexate; Guanidines; Male; Mice; Mice, Knockout; Pancreas; Plant Proteins; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Trypsin; Trypsin Inhibitors | 2002 |
CCK-58 is the only detectable endocrine form of cholecystokinin in rat.
Topics: alpha-Amylases; Amino Acid Sequence; Animals; Buffers; Cholecystokinin; Chromatography, High Pressure Liquid; Esters; Gabexate; Guanidines; Hydrogen-Ion Concentration; Iodine Radioisotopes; Isotope Labeling; Molecular Sequence Data; Peptide Fragments; Plant Proteins; Rats; Sincalide; Trypsin Inhibitors; Tyrosine | 2003 |
Morphological relationship between intercalated duct and pancreatic islet in streptozotocin and/or camostat mesilate administrations in the chicken.
Topics: Animals; Chickens; Esters; Gabexate; Guanidines; Immunohistochemistry; Islets of Langerhans; Microscopy, Electron; Pancreatic Ducts; Random Allocation; Streptozocin; Trypsin Inhibitors | 2003 |
Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice.
Topics: Animals; Esters; Gabexate; Guanidines; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne | 2003 |
Circulating ethanol does not stimulate pancreatic secretion in conscious rats.
Topics: Animals; Consciousness; Dose-Response Relationship, Drug; Duodenum; Esters; Ethanol; Gabexate; Guanidines; Infusions, Intravenous; Infusions, Parenteral; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Time Factors | 2003 |
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
Topics: Animals; Calcineurin; Cholecystokinin; Cyclosporine; Enzyme Inhibitors; Esters; Gabexate; Guanidines; Male; Mice; Mice, Inbred ICR; Pancreas; Protease Inhibitors; Tacrolimus | 2004 |
A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions.
Topics: Animals; Burns; Enzyme Inhibitors; Esters; Exudates and Transudates; Gabexate; Gastric Mucosa; Guanidines; Male; Microcirculation; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Skin; Stomach Ulcer; Stress, Physiological; Vascular Endothelial Growth Factor A; Venules | 2003 |
Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Arginine; Carrier Proteins; Cell Line; Chronic Disease; Drugs, Chinese Herbal; Esters; Gabexate; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Immunohistochemistry; In Situ Hybridization; Male; Nuclear Proteins; Pancreas; Pancreatitis; Rats; Rats, Inbred BN; Rats, Inbred Strains; Rats, Wistar; RNA, Messenger; Sequence Homology, Nucleic Acid; Tumor Suppressor Protein p53 | 2004 |
Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation.
Topics: Abdominal Pain; Acute Disease; Adult; Amino Acid Substitution; Amylases; Carrier Proteins; Diet, Fat-Restricted; Esters; Exons; Fasting; Female; Gabexate; Guanidines; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Introns; Mutation, Missense; Pancreatitis; Pedigree; Point Mutation; Pregnancy; Pregnancy Complications; Trypsin Inhibitor, Kazal Pancreatic; Ultrasonography | 2004 |
Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity.
Topics: Animals; Cell Proliferation; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Esters; Fibrosis; Gabexate; Guanidines; Male; Monocytes; Organotin Compounds; Pancreas; Pancreatitis; Procollagen; Protease Inhibitors; Rats; Rats, Inbred Lew; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Water and enzyme secretion are tightly coupled in pancreatic secretion stimulated by food or CCK-58 but not by CCK-8.
Topics: Animals; Bicarbonates; Body Water; Chlorides; Cholecystokinin; Esters; Food; Gabexate; Guanidines; Linear Models; Male; Pancreas; Rats; Rats, Wistar; Secretin; Sincalide; Time Factors | 2005 |
Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.
Topics: Actins; Amylases; Animals; Atrophy; Eating; Esters; Fibrosis; Gabexate; Guanidines; Interleukin-6; Lipase; Male; Obesity; Organ Size; Pancreas; Pancreatitis, Chronic; Protease Inhibitors; Rats; Rats, Inbred OLETF; Receptor, Cholecystokinin A; Transforming Growth Factor beta; Trypsin; Tumor Necrosis Factor-alpha | 2005 |
Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Eating; Esters; Fasting; Gabexate; Glucose Tolerance Test; Guanidines; Hyperlipidemias; Insulin; Insulin Resistance; Insulin Secretion; Lipids; Male; Obesity; Pancreas; Protease Inhibitors; Rats; Rats, Inbred OLETF | 2005 |
Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Ditiocarb; Drug Administration Schedule; Esters; Fibrosis; Gabexate; Guanidines; Male; Pancreas; Pancreatic Diseases; Procollagen-Proline Dioxygenase; Rats; Rats, Wistar; Severity of Illness Index; Treatment Outcome; Trypsin Inhibitors | 2005 |
Distribution of protease inhibitors in lipid emulsions: gabexate mesilate and camostat mesilate.
Topics: Emulsions; Esters; Gabexate; Guanidines; Lipids; Protease Inhibitors; Spectrometry, Fluorescence; Thermodynamics | 2005 |
Arginine vasopressin transport and metabolism in the pigmented rabbit conjunctiva.
Topics: Animals; Arginine Vasopressin; Biological Transport; Chromatography, High Pressure Liquid; Conjunctiva; Esters; Gabexate; Guanidines; In Vitro Techniques; Leupeptins; Male; Protease Inhibitors; Rabbits; Tritium | 1998 |
Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate.
Topics: Benzamidines; Chemistry, Pharmaceutical; Esters; Gabexate; Guanidines; Lactic Acid; Molecular Weight; Nanotubes; Particle Size; Peptides; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Protease Inhibitors; Solubility | 2006 |
Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Diet; DNA; Esters; Eukaryotic Initiation Factors; Gabexate; Guanidines; Male; Mice; Mice, Inbred ICR; Organ Size; Pancreas; Phosphoproteins; Phosphorylation; Protease Inhibitors; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Ribosomal Protein S6; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth.
Topics: Animals; Calcineurin; Esters; Eukaryotic Initiation Factor-4E; Gabexate; Guanidines; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Pancreas; Phosphorylation; Protein Kinases; Signal Transduction; Tacrolimus; TOR Serine-Threonine Kinases | 2006 |
[Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes].
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Drugs, Chinese Herbal; Esters; Gabexate; Guanidines; Lectins, C-Type; Pancreatitis-Associated Proteins; Pancreatitis, Chronic; Rats; Syndrome | 2006 |
Induction of early response genes in trypsin inhibitor-induced pancreatic growth.
Topics: Activating Transcription Factor 2; Activating Transcription Factor 3; Animals; Carbamates; Cholecystokinin; Early Growth Response Transcription Factors; Esters; Extracellular Signal-Regulated MAP Kinases; Gabexate; Gene Expression; Guanidines; Immediate-Early Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pancreas; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrimidinones; Receptors, Cholecystokinin; Transcription Factor AP-1; Trypsin Inhibitors | 2007 |
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.
Topics: Abdominal Pain; Animals; Ceruletide; Dose-Response Relationship, Drug; Esters; Gabexate; Guanidines; Male; Pain, Referred; Pancreatitis; Physical Stimulation; Posterior Horn Cells; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Trypsin | 2007 |
Pancreatic diabetes in a follow-up survey of chronic pancreatitis in Japan.
Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus; Esters; Female; Follow-Up Studies; Gabexate; Guanidines; Humans; Incidence; Japan; Male; Middle Aged; Pancreatitis, Alcoholic; Pancreatitis, Chronic; Risk Factors; Trypsin Inhibitors | 2007 |
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Topics: Animals; Calcineurin; Cell Line; Cell Nucleus; Cell Separation; Cholecystokinin; Esters; Gabexate; Green Fluorescent Proteins; Guanidines; Humans; Male; Mice; Mice, Inbred ICR; NFATC Transcription Factors; Pancreas, Exocrine; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Transcriptional Activation | 2008 |
The papilla of Vater just below the pylorus presenting as recurrent duodenal ulcer bleeding.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Bile; Bile Ducts; Duodenal Ulcer; Duodenum; Esters; Gabexate; Gastrointestinal Hemorrhage; Guanidines; Humans; Male; Pancreatic Ducts; Pancreatic Juice; Protease Inhibitors; Rabeprazole | 2007 |
CCK-induced pancreatic growth is not limited by mitogenic capacity in mice.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Autophagy; Carrier Proteins; Cell Cycle Proteins; Cholecystokinin; Cyclin-Dependent Kinase Inhibitor p21; DNA; Esters; Eukaryotic Initiation Factors; Gabexate; Gene Expression; Guanidines; Immunoblotting; Male; Mice; Mice, Inbred ICR; Microtubule-Associated Proteins; Mitosis; Organ Size; Pancreas; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; TOR Serine-Threonine Kinases; Ubiquitin-Protein Ligases | 2008 |
Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat.
Topics: Animals; Cholecystokinin; Devazepide; Eating; Esters; Gabexate; Gastrointestinal Tract; Guanidines; Hormone Antagonists; Models, Biological; Myenteric Plexus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Solitary Nucleus; Submucous Plexus; Vagus Nerve | 2008 |
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Esters; Gabexate; Guanidines; Hypertension; Kidney; Mice; Rats; Rats, Inbred Dahl; RNA, Small Interfering; Serine Endopeptidases; Serine Proteinase Inhibitors | 2009 |
Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.
Topics: Animals; Bronchi; Cells, Cultured; Epithelial Cells; Epithelial Sodium Channels; Esters; Gabexate; Guanidines; Guinea Pigs; Humans; Male; Membrane Potentials; Mucociliary Clearance; Peptide Hydrolases; Protease Inhibitors; Respiratory Mucosa; Sheep; Trachea | 2009 |
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Topics: Aprotinin; Calcium; Catalytic Domain; Cations, Divalent; Chymotrypsin; Crystallography, X-Ray; Esters; Gabexate; Guanidines; Humans; Protease Inhibitors; Protein Conformation; Sequence Alignment; Serine Endopeptidases; Substrate Specificity | 2009 |
ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock.
Topics: Allylglycine; Animals; Benzamidines; Cell Line, Tumor; Culture Media, Conditioned; Esters; Female; Gabexate; Gene Expression; Guanidines; I-kappa B Proteins; Interferon Regulatory Factor-3; Interferon-gamma; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Serine Proteases; Serine Proteinase Inhibitors; Shock, Septic; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2011 |
Regulator of calcineurin 1 controls growth plasticity of adult pancreas.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium-Binding Proteins; Cell Proliferation; Cholecystokinin; Diet; Enzyme Inhibitors; Esters; Feedback, Physiological; Gabexate; Gene Expression Profiling; Gene Expression Regulation; Guanidines; Integrases; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred ICR; Mice, Transgenic; Muscle Proteins; NFATC Transcription Factors; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Organ Size; Pancreas; Pancreatic Elastase; Protease Inhibitors; Receptor, Cholecystokinin A; Receptors, Estrogen; Signal Transduction; Tacrolimus; Time Factors; Transfection | 2010 |
Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate.
Topics: Adult; Benzamidines; Chronic Disease; Drug Therapy, Combination; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Protease Inhibitors; Treatment Outcome; Urticaria | 2010 |
The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Eating; Esters; Feeding Behavior; Gabexate; Guanidines; Male; Motor Activity; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Satiety Response; Sincalide; Time Factors | 2011 |
Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds.
Topics: Administration, Oral; Animals; Cattle; Colon; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Stability; Esters; Gabexate; Glycocholic Acid; Guanidines; Hypoglycemic Agents; Hypromellose Derivatives; Insulin; Intestinal Absorption; Methylcellulose; Protease Inhibitors; Solubility; Surface Properties; Tablets, Enteric-Coated; Viscosity | 2011 |
Duodenal myotomy blocks reduction of meal size and prolongation of intermeal interval by cholecystokinin.
Topics: Analysis of Variance; Animals; Autonomic Denervation; Cholecystokinin; Duodenum; Eating; Esters; Feeding Behavior; Gabexate; Gene Expression Regulation; Guanidines; Male; Muscle Denervation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; RNA, Messenger; Sincalide; Time Factors | 2012 |
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Transformation, Neoplastic; Ceruletide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Induction; Esters; Feedback, Physiological; Gabexate; Gene Expression Regulation, Neoplastic; Gene Knock-In Techniques; Genes, ras; Guanidines; Humans; I-kappa B Kinase; Inflammation; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Transgenic; Neoplasm Proteins; NF-kappa B; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Precancerous Conditions; Proto-Oncogene Proteins p21(ras); Sincalide | 2012 |
In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats.
Topics: Aldosterone; Animals; Blood Pressure; Chlorides; Epithelial Sodium Channels; Esters; Gabexate; Guanidines; Male; Potassium; Rats; Rats, Sprague-Dawley; Serine Proteases; Serine Proteinase Inhibitors; Sodium | 2012 |
Effect of a serine protease inhibitor on the progression of chronic renal failure.
Topics: Animals; Creatinine; Disease Progression; Esters; Gabexate; Guanidines; Kidney; Kidney Failure, Chronic; Male; Membrane Proteins; Microfilament Proteins; Nephrectomy; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Treatment Outcome | 2012 |
The antifibrotic effect of a serine protease inhibitor in the kidney.
Topics: Animals; Cell Line; Chemokine CCL2; Esters; Fibroblasts; Gabexate; Guanidines; Macrophages; Nephrosclerosis; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 2013 |
Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.
Topics: Antiviral Agents; Cell Line; Cell Membrane; Coronavirus; Coronavirus Infections; Esters; Gabexate; Giant Cells; Guanidines; Humans; Serine Endopeptidases; Serine Proteinase Inhibitors; Virus Internalization | 2013 |
Acute pancreatitis secondary to ciprofloxacin therapy in patients with infectious colitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Colitis; Enzyme Inhibitors; Esters; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Pancreatitis; Young Adult | 2014 |
[Camostat mesilate, a protease inhibitor, inhibits visceral sensitivity and spinal c-fos expression in rats with acute restraint stress].
Topics: Animals; Esters; Gabexate; Guanidines; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Restraint, Physical; Spinal Cord; Stress, Physiological | 2014 |
Protease inhibitors targeting coronavirus and filovirus entry.
Topics: Animals; Antiviral Agents; Cathepsins; Cell Line, Tumor; Coronavirus; Coronavirus Infections; Dipeptides; Ebolavirus; Esters; Filoviridae; Gabexate; Guanidines; Humans; Mice; Mice, Inbred BALB C; Phenylalanine; Piperazines; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Severe acute respiratory syndrome-related coronavirus; Tosyl Compounds; Vinyl Compounds; Virus Internalization | 2015 |
The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Creatinine; Disease Progression; Esters; Fibrosis; Free Radical Scavengers; Gabexate; Guanidines; Hydralazine; Kidney; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Serine Proteinase Inhibitors | 2015 |
The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.
Topics: Aged; Animals; Aprotinin; Cells, Cultured; Dogs; Epithelial Cells; Esters; Female; Gabexate; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza, Human; Madin Darby Canine Kidney Cells; Male; Middle Aged; RNA, Viral; Serine Proteinase Inhibitors; Trachea; Virus Replication | 2015 |
Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
Topics: Administration, Oral; Animals; Biomarkers; Bombesin; Cell Proliferation; Cholecystokinin; Disease Models, Animal; DNA Replication; Esters; Gabexate; Guanidines; Hormone Antagonists; Insulin Resistance; Male; Pancreas; Pancreatic Function Tests; Pancreatitis; Proglumide; Rats, Wistar; Receptor, Cholecystokinin A; Recovery of Function; Taurocholic Acid; Time Factors | 2015 |
Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin.
Topics: Administration, Oral; Chitosan; Drug Carriers; Drug Delivery Systems; Endocytosis; Esters; Gabexate; Guanidines; Insulin; Intestinal Mucosa; Ligands; Nanoparticles; Polyglutamic Acid; Trypsin; Trypsin Inhibitors | 2015 |
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
Topics: Aprotinin; Bronchi; Catalytic Domain; Cells, Cultured; Epithelial Cells; Esters; Gabexate; Guanidines; Humans; Serine Endopeptidases; Serine Proteinase Inhibitors; Tryptases | 2015 |
The feeding responses evoked by endogenous cholecystokinin are regulated by different gastrointestinal sites.
Topics: Animals; Celiac Artery; Cholecystokinin; Eating; Esters; Feeding Behavior; Femoral Artery; Gabexate; Guanidines; Male; Mesenteric Artery, Superior; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Time Factors | 2016 |
Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Creatinine; Disease Models, Animal; Drug Therapy, Combination; Esters; Fibrosis; Gabexate; Guanidines; Kidney; Male; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Renin; Renin-Angiotensin System; Serine Proteinase Inhibitors; Telmisartan | 2016 |
Autoimmune hepatitis following drug-induced liver injury in an elderly patient.
Topics: Aged; Benzbromarone; Biopsy; Chemical and Drug Induced Liver Injury; Esters; Gabexate; Guanidines; Hepatitis, Autoimmune; Hepatitis, Chronic; Humans; Liver; Male; Uricosuric Agents | 2016 |
Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities.
Topics: Abdominal Pain; Aged; Benzamides; Drug Therapy, Combination; Dyspepsia; Esters; Female; Gabexate; Gastrointestinal Agents; Guanidines; Humans; Male; Middle Aged; Pancreatitis, Chronic; Pancrelipase; Rabeprazole; Thiazoles; Treatment Outcome | 2019 |
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Topics: Ammonium Chloride; Angiotensin-Converting Enzyme 2; Animals; Antibodies, Neutralizing; Antibodies, Viral; Betacoronavirus; Cell Line; Coronavirus; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Drug Development; Esters; Gabexate; Guanidines; Humans; Immunization, Passive; Leucine; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Protease Inhibitors; Receptors, Virus; SARS-CoV-2; Serine Endopeptidases; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus; Vesiculovirus; Virus Internalization | 2020 |
Learning from our immunological history: What can SARS-CoV teach us about SARS-CoV-2?
Topics: Angiotensin-Converting Enzyme 2; Animals; Antibodies, Neutralizing; Antibodies, Viral; Betacoronavirus; Cell Line; Coronavirus Infections; COVID-19; Esters; Gabexate; Guanidines; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Rabbits; SARS-CoV-2; Serine Endopeptidases; Serine Proteinase Inhibitors; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus | 2020 |
Camostat mesilate therapy for COVID-19.
Topics: Animals; Coronavirus Infections; COVID-19; Disease Models, Animal; Esters; Gabexate; Guanidines; Japan; Mesylates; Mice; Pandemics; Pneumonia, Viral; Serine Endopeptidases | 2020 |
Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2).
Topics: Amino Acid Sequence; Betacoronavirus; Catalytic Domain; Computer Simulation; Coronavirus Infections; COVID-19; Drug Design; Drug Evaluation, Preclinical; Esters; Gabexate; Guanidines; Humans; Models, Molecular; Molecular Docking Simulation; Pandemics; Pneumonia, Viral; SARS-CoV-2; Serine Endopeptidases; Serine Proteinase Inhibitors; Small Molecule Libraries | 2020 |
Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.
Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Cells, Cultured; Coronavirus 229E, Human; Coronavirus Infections; COVID-19; Culture Media, Conditioned; Epithelial Cells; Esters; Gabexate; Guanidines; Humans; Nasal Mucosa; Pandemics; Pneumonia, Viral; Primary Cell Culture; Protease Inhibitors; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Viral Load; Virus Replication | 2020 |
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticoagulants; Benzamidines; Betacoronavirus; Cell Line; Chlorocebus aethiops; Coronavirus Infections; COVID-19; Esters; Gabexate; Guanidines; HEK293 Cells; Humans; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Vero Cells; Virus Internalization | 2020 |
The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer.
Topics: Androgens; Angiotensin-Converting Enzyme 2; Betacoronavirus; Carcinogenesis; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Disease Progression; Esters; Estrogens; Gabexate; Gene Expression Regulation, Neoplastic; Guanidines; Humans; Lung; Male; Oncogene Proteins, Fusion; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Polymorphism, Single Nucleotide; Prostate; Prostatic Neoplasms; Protease Inhibitors; RNA-Seq; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Virus Internalization | 2020 |
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; Esters; Gabexate; Glycine; Guanidines; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; SARS-CoV-2; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19.
Topics: Amides; Anti-Bacterial Agents; Antiviral Agents; Binding Sites; COVID-19 Drug Treatment; Drug Repositioning; Esters; Gabexate; Guanidines; Molecular Docking Simulation; Phytochemicals; Protein Binding; Pyrazines; Raltegravir Potassium; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Stavudine; Tenofovir | 2021 |
Mechanisms of NMDA receptor inhibition by nafamostat, gabexate and furamidine.
Topics: Animals; Benzamidines; Drug Repositioning; Esters; Gabexate; Guanidines; Hippocampus; Inhibitory Concentration 50; Male; Models, Animal; Neurodegenerative Diseases; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine Proteinase Inhibitors | 2022 |
Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene.
Topics: Acid Sensing Ion Channels; Animals; Diminazene; Gabexate; Guanidines; Hydrogen-Ion Concentration; Rats | 2023 |
Inhibition of Listeria Monocytogenes HtrA Protease with Camostat, Gabexate and Nafamostat Mesylates and the Binding Mode of the Inhibitors.
Topics: COVID-19; Gabexate; Humans; Listeria monocytogenes; Mesylates; Peptide Hydrolases; Protease Inhibitors; RNA, Viral; SARS-CoV-2 | 2023 |