calpeptin and calpain
calpeptin has been researched along with calpain in 200 studies
Research
Studies (200)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.50) | 18.7374 |
| 1990's | 42 (21.00) | 18.2507 |
| 2000's | 80 (40.00) | 29.6817 |
| 2010's | 70 (35.00) | 24.3611 |
| 2020's | 7 (3.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fukami, M; Maeda, Y; Minami, N; Tani, E; Yamaura, I | 1 |
| Ariyoshi, H; Kambayashi, J; Kang, J; Kawasaki, T; Kawashima, S; Mori, T; Sakon, M; Shiba, E | 1 |
| Bossuet, C; Ducastaing, A; Letard, P; Pallet, V; Savart, M | 1 |
| Ariyoshi, H; Kambayashi, J; Mori, T; Sakon, M; Shiba, E; Tsujinaka, T; Uemura, Y | 1 |
| Higuchi, N; Kajiwara, Y; Kambayashi, J; Mori, T; Sakon, M; Tanaka, T; Tsujinaka, T | 1 |
| Ariyoshi, H; Druker, BJ; Oda, A; Salzman, EW; Smith, M | 1 |
| Ariyoshi, H; Oda, A; Salzman, EW | 1 |
| Aszódi, A; Friedrich, P; Ginzburg, I; Pintér, M | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Tsuji, Y | 1 |
| Bassé, F; Bienvenüe, A; Gaffet, P | 1 |
| Banik, N; Figueiredo-Pereira, ME; Wilk, S | 1 |
| Gotoh, M; Kanai, T; Monden, M; Mori, T; Murata, M; Nakano, H; Umeshita, K | 1 |
| Mann, KG; Swords, NA; Tracy, PB | 1 |
| Fujitani, K; Kambayashi, J; Kang, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Yano, Y | 1 |
| Haug, LS; Magnusson, A; Ostvold, AC; Walaas, SI | 1 |
| Ariyoshi, H; Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Yoshida, K | 1 |
| Hathaway, DR; March, KL; Roeske, RW; Wilensky, RL | 1 |
| Chung, CH; Ha, DB; Kambayashi, J; Kang, MS; Kwak, KB | 1 |
| Duncan, G; Marcantonio, JM; Sanderson, J | 1 |
| Barnoy, S; Glasner, T; Kosower, NS | 1 |
| Cooray, P; Jackson, SP; Mitchell, CA; Salem, HH; Schoenwaelder, SM; Yuan, Y | 1 |
| Balcerzak, D; Brustis, JJ; Cottin, P; Dourdin, N; Ducastaing, A; Elamrani, N; Poussard, S | 1 |
| Fujitani, K; Gotoh, M; Imajoh-Ohmi, S; Kambayashi, J; Miyoshi, H; Monden, M; Oiki, E; Sakon, M; Umeshita, K | 1 |
| Breton-Douillon, M; Chap, H; Mauco, G; Montsarrat, N; Payrastre, B; Plantavid, M; Racaud-Sultan, C | 1 |
| Atkins, RC; Majerus, PW; Norris, FA | 1 |
| Di Lisa, F; Gorza, L; Menabó, R; Vitadello, M | 1 |
| Haass, C; Ihara, Y; Omura, S; Saido, TC; Yamazaki, T | 1 |
| Fujitani, K; Ikeda, M; Kambayashi, J; Kawashima, S; Miyoshi, H; Monden, M; Ohmi, SI; Sakon, M; Shinoki, N; Yano, Y; Yukawa, M | 1 |
| Ariyoshi, H; Fujitani, K; Imajoh-Ohmi, S; Kambayashi, J; Monden, M; Nakamura, T; Sakon, M | 1 |
| Imajoh-Ohmi, S; Jackson, SP; Kulkarni, S; Saido, TC; Salem, HH; Schoenwaelder, SM; Yamao-Harigaya, W | 1 |
| Ariyoshi, H; Kambayashi, J; Kawasaki, T; Kawashima, S; Monden, M; Okahara, K; Sakon, M | 1 |
| Baudry, M; Bi, X; Chen, J; Dang, S; Rong, Y; Wang, Z | 1 |
| Gitler, D; Spira, ME | 2 |
| Beavis, RC; Berman, Y; Devi, LA; Newcomb, EW; Reed, JC; Thomas, A; Wood, DE | 1 |
| Brown, SB; Knepper-Nicolai, B; Savill, J | 1 |
| Balcerzak, D; Brustis, JJ; Cottin, P; Dourdin, N; Ducastaing, A; Poussard, S | 1 |
| Newcomb, EW; Wood, DE | 1 |
| Burridge, K; Schoenwaelder, SM | 1 |
| Banik, NL; Crosby, CV; Hogan, EL; Ray, SK; Wilford, GG | 1 |
| Bachelot-Loza, C; Brohard-Bohn, B; Cano, E; Falet, H; Fraiz, N; Monstero-Lastres, A; Pain, S; Rendu, F | 1 |
| Gurd, JW; Lombroso, PJ; Nguyen, TH; Paul, S; Xu, Y | 1 |
| Hayashi, S; Itoh, M; Kuro, T; Matsumura, Y; Takaoka, M | 1 |
| Kim, S; Nelson, PG | 1 |
| Banik, NL; Hogan, EL; Matzelle, DC; Ray, SK; Wilford, GG | 1 |
| Medina, MA; Olmo, MT; Rodríguez-Agudo, D; Sánchez-Jiménez, F | 1 |
| Block, ER; Su, Y | 1 |
| Dou, QP; Gao, G | 1 |
| Airas, L; Jalkanen, S; Niemelä, J | 1 |
| Brooks, WH; Dix, AR; Rock, MT; Roszman, TL | 1 |
| Canty, JM; Fallavollita, JA; Feng, J; Lee, TC; Schaus, BJ | 1 |
| Gibson, RM; Hickman, JA; Lesay, A | 1 |
| Radhika, G; Sarin, A; Varghese, J | 1 |
| Burgess, HA; Reiner, O | 1 |
| Banno, Y; Nakashima, S; Nishimura, Y; Nozawa, Y; Sakai, N; Sawada, M; Yamakawa, H; Yoshimura, S | 1 |
| Froehner, SC; Guo, J; Ort, T; Solimena, M; Voronov, S; Zawalich, K; Zawalich, W | 1 |
| Dash, D; Mukhopadhyay, S; Ochs, HD; Ramars, AS | 1 |
| Becker, CM; Herkert, M; Schweins, E; Shakhman, O | 1 |
| Kim, HT; Qiang, W; Stoica, G; Wong, PK | 1 |
| Bogyo, A; Chap, H; Paulhe, F; Perret, B; Racaud-Sultan, C | 1 |
| Kenney, DM; Miki, H; Remold-O'Donnell, E; Rosen, FS; Shcherbina, A; Takenawa, T | 1 |
| Botion, LM; Brasier, AR; Green, A; Tian, B; Udupi, V | 1 |
| Ha, KS; Kim, S; Kim, SJ; Kweon, SM; Lee, ZW | 1 |
| Jung, YK; Kim, BJ | 1 |
| Gilligan, DM; Sarid, R; Weese, J | 1 |
| Hansson, J; Heiden, T; Linder, S; Mandic, A; Shoshan, MC; Strandberg, L; Viktorsson, K | 1 |
| Chou, TY; Dang, CV; Orlowski, RZ; Small, GW | 1 |
| Grbovic, OM; Jiang, Y; Mathews, PM; Mercken, M; Nixon, RA; Schmidt, SD | 1 |
| Caro, AA; Cederbaum, AI | 1 |
| Joussen, AM; Kirchhof, B; Lappas, A; Mitsiades, CS; Mitsiades, N; Poulaki, V | 1 |
| Befus, AD; Forsythe, P | 1 |
| Agerholm-Larsen, B; Chen, W; Linsel-Nitschke, P; Martinez, LO; Silver, DL; Tall, AR; Wang, N | 1 |
| Banfić, H; Batinić, D; Crljen, V; Curić, J; Visnjić, D; Volinia, S | 1 |
| Fujioka, H; Kamohara, Y; Kanematsu, T; Ohtsuru, A; Tamura, H; Yamashita, S; Yanaga, K | 1 |
| Bittner, GD; Fishman, HM; Fukuda, M; Nguyen, MP; Yoo, S | 1 |
| Potrovita, I; Prinz, S; Schölzke, MN; Schwaninger, M; Subramaniam, S | 1 |
| Burlingame, AL; Fainzilber, M; Hanz, S; Medzihradszky, KF; Perlson, E | 1 |
| Brustis, JJ; Cottin, P; Dargelos, E; Dedieu, S; Grise, F; Mazères, G; Poussard, S | 1 |
| Dash, D; Dikshit, M; Gupta, R; Karim, ZA; Mukhopadhyay, S; Wadhawan, V | 1 |
| Banik, NL; Goust, JM; Schaecher, K | 1 |
| Amin, N; Arancio, O; Basavarajappa, BS; Boland, B; Cataldo, A; Hungund, BL; Kaji, T; Li, BS; Mohan, P; Nixon, RA; Odrljin, T; Pant, HC; Peterhoff, C; Rudnicki, A | 1 |
| Eggo, MC; Langman, MJ; Lewis, AE; Susarla, R; Wong, BC | 1 |
| Evenson, A; Fareed, MU; Hasselgren, PO; Menconi, MJ; Petkova, V; Wei, W; Yang, H | 1 |
| Lindsay, AJ; Marie, N; McCaffrey, MW | 1 |
| Bosco, D; Hammar, E; Parnaud, G; Rouiller, DG | 1 |
| Ben-Aharon, I; Brown, PR; Eddy, EM; Etkovitz, N; Shalgi, R | 1 |
| Hayashi, M; Inomata, M; Ishibashi, H; Kawashima, S; Koshihara, Y; Saido, TC; Tsubuki, S; Yamamoto, S | 1 |
| Appel, SH; Banik, NL; Das, A; Del Re, AM; Ray, SK; Sribnick, EA; Wingrave, JM; Woodward, JJ | 1 |
| Jacobs, JM; Nichols, RC; Noreault, TL; Sinclair, JF; Sinclair, PR; Trask, HW; Wrighton, SA | 1 |
| Ando, K; Kudo, Y; Takahashi, M | 1 |
| Ben-Aharon, I; Ben-Yosef, D; Haim, K; Shalgi, R | 1 |
| Baba, HA; Heusch, G; Keul, P; Levkau, B; Lucke, S; von Wnuck Lipinski, K; Wohlschlaeger, J | 1 |
| Evenson, AR; Fareed, MU; Hasselgren, PO; Menconi, M; Petkova, V; Pignol, B; Poylin, V; Wei, W | 1 |
| Cao, P; Chamberlain, C; Hasselgren, PO; Menconi, M; Petkova, V; Wei, W; Yang, H | 1 |
| Henderson, B; Moshal, KS; Rosenberger, DS; Sen, U; Singh, M; Tyagi, N; Tyagi, SC; Zhang, H | 1 |
| Bay, BH; Cheung, NS; Li, Y; Qi, RZ; Sheu, FS; Tan, CH; Whiteman, M; Yap, YW | 1 |
| Brustis, JJ; Cottin, P; Daury, L; Leloup, L; Mazères, G | 1 |
| Ali, SF; Banik, NL; Ray, SK; Samantaray, S | 1 |
| Dreolini, L; Takei, F | 1 |
| Brown, CS; Dean, WL | 1 |
| Kim, KA; Lee, YA; Shin, MH | 2 |
| Arboleda, G; Gibson, R; Waters, C | 1 |
| Honda, K; Miyazaki, T; Ohata, H | 1 |
| Aroca-Aguilar, JD; Coca-Prados, M; Escribano, J; Martínez-Redondo, F; Sánchez-Sánchez, F | 1 |
| Banik, NL; Guyton, MK; Haque, A; Imam, SA; Ray, SK; Tyor, WR; Vandenbark, A | 1 |
| Asmuth, DM; Kung, HJ; Libertini, SJ; Mudryj, M; Rodriguez, V; Tepper, CG | 1 |
| Cotter, TG; Guerin, MB; McKernan, DP; O'Brien, CJ | 1 |
| Choi, KC; Chung, WT; Hwang, IH; Kook, SH; Lee, CB; Lee, HJ; Lee, JC; Lee, KY; Park, JS; Son, YO | 1 |
| Li, XJ; Li, YH; Lin, YH; Shen, ZF; Tie, L; Wu, HL; Xu, Y; Yao, XH; Yu, HM | 1 |
| de Wolff, FA; Romijn, F; Vahidnia, A; van der Straaten, RJ; van der Voet, GB; van Pelt, J | 1 |
| Evans, MK; Hill, JW; Hu, JJ | 1 |
| Balasubramanian, S; Banik, N; Chellaiah, M; Cooper, G; Kuppuswamy, D; Mani, SK; Shiraishi, H; Yamane, K; Zile, MR | 1 |
| Lee, S; Price, P; Roberts, S; Temple, S | 1 |
| Balakrishnan, K; Gandhi, V; Keating, MJ; Wierda, WG | 1 |
| Antonucci, F; Berghuis, P; Bonanno, G; Caleo, M; Carmignoto, G; Dobszay, MB; Grumelli, C; Harkany, T; Matteoli, M; Pozzi, D; Verderio, C | 1 |
| Banik, NL; Beeson, CC; Butler, JT; Ray, SK; Samantaray, S | 1 |
| Banik, NL; Butler, JT; Ray, SK; Samantaray, S | 1 |
| Cai, H; Wang, T; Youn, JY | 1 |
| Chakraborti, S; Chakraborti, T; Kar, P; Samanta, K | 2 |
| Fernández-Muñoz, B; Martín-Villar, E; Quintanilla, M; Renart, J; Yurrita, MM | 1 |
| Biagioli, M; Cosci, E; Del Bello, B; Maellaro, E; Miracco, C; Moretti, D | 1 |
| Anantharaman, A; Bungert, J; Crusselle-Davis, VJ; Gandhi, K; Huang, S; Jayandharan, G; Lin, IJ; Moghimi, B; Pantic, D; Srivastava, A; Zhong, L; Zhou, Z | 1 |
| Brulé, C; Cottin, P; Dargelos, E; Mouly, V; Poussard, S; Stuelsatz, P; Veschambre, P | 1 |
| Balasubramanian, S; Jeffords, LB; Kuppuswamy, D; Mani, SK; Mukherjee, R; Rivers, WT; Spinale, FG; Zavadzkas, JA; Zile, MR | 1 |
| Butler, AE; Butler, PC; Costes, S; Daval, M; Gurlo, T; Haataja, L; Huang, CJ; Ryazantsev, S; Wu, X | 1 |
| Chen, CJ; Nguyen, T; Shively, JE | 1 |
| Bolshakov, A; Brustovetsky, N; Brustovetsky, T | 1 |
| Balasubramanian, S; Kasiganesan, H; Kuppuswamy, D; Suryakumar, G | 1 |
| Bang, KW; Freedman, J; Gwozdz, AM; Leung, R; Packham, MA; Rand, ML; Wang, H | 1 |
| Banik, NL; Butler, JT; Das, A; Guyton, MK; Ray, SK; Samantaray, S; Wallace, GC | 1 |
| Bae, CD; Han, BG; Kim, DS; Kim, SY; Lee, BI; Park, KS | 1 |
| Banik, NL; Das, A; Nozaki, K; Ray, SK | 2 |
| Bastián, Y; Hernández-González, EO; Mújica, A; Roa-Espitia, AL | 1 |
| Nakano, T; Tabata, C; Tabata, R | 1 |
| Hayashi, H; Hori, N; Sugiyama, Y | 1 |
| Auladell, C; Beas-Zarate, C; Camins, A; Folch, J; Junyent, F; Pallàs, M; Pizarro, JG; Verdaguer, E | 1 |
| Al-Bahlani, S; Bergeron, R; Fraser, M; Melino, G; Sayan, BS; Tsang, BK; Wong, AY | 1 |
| Banik, NL; Das, A; Guyton, MK; Ray, SK; Rohrer, B; Smith, AW | 1 |
| Jantas, D; Kubera, M; Lason, W; Lorenc-Koci, E | 1 |
| Banik, NL; Knaryan, VH; Le Gal, C; Ray, SK; Samantaray, S | 1 |
| Jang, YS; Kim, JY; Kim, KA; Lee, SK; Lee, YA; Shin, MH; Song, KJ | 1 |
| Hwang, IH; Shiwani, S; Singh, NK | 1 |
| Bonner, H; Courtney, MJ; D'Orsi, B; Düssmann, H; Prehn, JH; Tuffy, LP; Ward, MW; Woods, I | 1 |
| Morgado, AL; Rodrigues, CM; Santos, DM; Solá, S; Xavier, JM | 1 |
| Chun, J; Parker, D; Prince, A; Soong, G | 1 |
| Castiglioni, S; Maier, JA | 1 |
| Gao, L; Yang, HT; Zhang, CM; Zheng, YJ | 1 |
| Banik, NL; Guyton, MK; Nozaki, K; Park, S; Ray, SK; Smith, JA | 1 |
| Chen, L; Feng, XC; Xu, XL; Zhang, WG; Zhou, GH | 1 |
| Hwang, SH; Kim, HS; Kim, MJ; Kim, SS; Lim, JA | 1 |
| Banik, NL; Das, A; Guyton, MK; Matzelle, DD; McDowell, ML; Ray, SK; Smith, A; Wallace, G | 1 |
| Chishti, AH; Collins, P; Cosemans, JM; Gilio, K; Heemskerk, JW; Jobe, SM; Mattheij, NJ; van Kruchten, R; Wieschhaus, AJ | 1 |
| Geha, RS; Kumaki, S; Kure, S; Massaad, MJ; Ramesh, N; Sasahara, Y; Tsuchiya, S; Watanabe, Y; Yeng Looi, C | 1 |
| Autheman, D; Christen, S; D'Herde, K; Popoff, M; Posthaus, H; Wyder, M | 1 |
| Bahr, BA; Bojcevski, J; Diem, R; Fairless, R; Hoffmann, DB; Müller, A; Naidoo, V; Stadelmann, C; Williams, SK | 1 |
| Baek, JY; Jeong, JY; Jin, BK; Ju, C; Kim, C; Kim, WK; Lee, YM; Oh, YJ; Song, HY; Youdim, MB; Yun, N | 1 |
| Endo-Umeda, K; Imai, T; Ishige, K; Ito, Y; Kosuge, Y; Makishima, M; Miyagishi, H | 1 |
| Berkman, CE; Liu, T; Mendes, DE | 1 |
| Chang, NC; Chen, YH; Huang, CY; Lee, CY; Li, CY; Lin, CY; Lin, FY; Lin, YW; Shih, CM; Tsai, CS; Tsai, JC; Tsai, YT | 1 |
| Chen, M; Nguyen, HT | 1 |
| Cheng, X; Lin, Y; Mao, X; Zhang, J; Zhou, T | 1 |
| Chen, X; Guo, H; Huang, J; Ma, S; Shi, L; Zhu, X | 1 |
| Billiar, TR; Boone, DL; Cham, CM; Chang, EB; Chang, J; Lin, F; Lotze, MT; Messer, JS; Wang, Y; Zhu, X | 1 |
| Dash, D; Kumari, S; Mallick, RL; Singh, N; Sonkar, VK | 1 |
| Bollag, WB; Schnellmann, RG; Seremwe, M | 1 |
| Banik, NL; Becker, HC; Knaryan, VH; Mulholland, PJ; Patel, KS; Samantaray, S | 1 |
| Banik, NL; Cox, AA; Haque, A; Knaryan, VH; Samantaray, S; Shields, DC | 1 |
| Derksen, M; Siemen, D; Vorwerk, C | 1 |
| Shintani-Ishida, K; Yoshida, K | 1 |
| Ansa-Addo, EA; Inal, J; Jorfi, S; Kholia, S; Lange, S; Stratton, D; Valley, S | 1 |
| E, M; Li, G; Wang, S; Wei, X; Yan, F; Yang, X; Yu, S; Zhang, C; Zhang, F | 1 |
| Cappadone, C; Castiglioni, S; Cazzaniga, A; Farruggia, G; Iotti, S; Maier, JAM; Merolle, L; Trapani, V; Wolf, FI | 1 |
| Akhlaq, M; Al Ghamdi, S; Ilyas, M; Jackson, D; Martin, S; Storr, S; Thorpe, H | 1 |
| Fujita, H; Manabe, T; Miyasaka, Y; Mizumoto, K; Nabae, T; Nakamura, M; Ohtsuka, T; Ohuchida, K; Okumura, T; Shimamoto, M; Torata, N; Yoshida, M; Zheng, B | 1 |
| Azuma, M; Banik, NL; Chauhan, A; Das, A; Hogan, EL; Inoue, J; Nozaki, K; Podbielska, M; Ray, SK; Smith, AW | 1 |
| Cai, PC; Fang, J; Greer, PA; Li, FZ; Lin, YX; Liu, F; Ma, WL; Mu, Q; Rao, SS; Shi, HZ; Song, LJ; Su, Y; Xia, Y; Yang, J; Ye, H; Zeng, Y; Zhang, Q; Zhou, LL | 1 |
| Gandour, CE; Gardner, JS; Krishnan, HC; Lentsch, CT; Lyons, LC; Noakes, EJ | 1 |
| Beke Debreceni, I; Czimmerer, Z; Fejes, Z; Gál Szabó, G; Káplár, M; Kappelmayer, J; Kunapuli, SP; Nagy, B; Penyige, A; Póliska, S | 1 |
| Dao, CV; Miyamoto, A; Shiraishi, M | 1 |
| Greer, PA; Huang, H; Ma, WL; Shi, HZ; Song, LJ; Su, Y; Xiang, F; Xin, JB; Xiong, L; Xu, JJ; Yang, J; Ye, H; Yu, F | 1 |
| Guan, Q; Jiang, W; Liu, N; Su, B; Wang, M; Wang, S; Wei, X; Xu, M; Yang, X; Yu, S | 1 |
| Akyürek, LM; Ala, C; Alvandian, A; Bandaru, S; Devarakonda, S; Gökalp, S; Salimi, R; Yener, N | 1 |
| Cheng, ZS; Liu, B; Liu, Y; Zhang, GQ; Zou, JF; Zou, ML | 1 |
| Bakker-van Bebber, M; Nijenhuis, T; Sonneveld, R; van der Vlag, J; Verheijden, KAT; Wetzels, JFM | 1 |
| Chen, C; Chen, S; Hu, Z; Li, F; Liu, T; Tao, Z; Zuo, J | 1 |
| Bizzozero, OA; Hu, CL; Smerjac, SM; Zheng, J | 1 |
| de la Fuente, S; Garcera, A; Periyakaruppiah, A; Sansa, A; Soler, RM | 1 |
| Abdel-Aziz, S; Fitze, D; Flück, M; Gerber, C; Jungck, L; Kindt, P; Klein, K; Oberholzer, L; Rohner, M; Rosskopf, AB; Ruoss, S; von Rechenberg, B; Wieser, K | 1 |
| Chen, G; Dong, J; Gong, Z; Guo, L; Jiang, M; Li, G; Lin, L; Liu, S; Pan, R; Tang, H; Wang, J; Xing, Y; Yan, L | 1 |
| Enomoto, A; Fukasawa, T; Karube, M; Miura, Y; Miyagawa, K; Nakagawa, K; Sato, S; Tsumoto, H; Yoshizaki, A | 1 |
| Cai, L; Li, Q; Li, W; Lu, X; Su, Z; Tu, M; Wang, C; Zhu, Z | 1 |
| Shen, F; Song, Z; Wu, S; Zhang, Z; Zhu, G | 1 |
| de la Fuente, S; Garcera, A; Hidalgo, I; Romero-Guevara, R; Sansa, A; Soler, RM; Vivancos, N | 1 |
| Baburuna, Y; Krestinina, O; Sotnikova, L | 1 |
| Li, M; Li, T; Liu, X; Pan, X; Qiao, L; Tang, Z; Wang, G; Yi, S; Zhou, S | 1 |
| Inal, J; Paizuldaeva, A; Terziu, E | 1 |
| Abdallah, DM; El-Abhar, HS; Fayez, AM; Mohamed, OE; Mohamed, RA | 1 |
Other Studies
200 other study(ies) available for calpeptin and calpain
| Article | Year |
|---|---|
Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calpain; Dipeptides; Dogs; Ischemic Attack, Transient; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Vasoconstriction | 1992 |
Membrane binding and autolytic activation of calpain-I in human platelets.
Topics: Biological Transport; Blood Platelets; Calcium; Calpain; Cell Membrane; Cytosol; Dipeptides; Enzyme Activation; Humans; Immunoblotting; Protein Binding | 1992 |
Calpain 1-protein kinase C complex: effect of calpain inhibitors after dissociation.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Calpain; Dipeptides; Enzyme Activation; Enzyme Stability; Leupeptins; Male; Molecular Sequence Data; Muscles; Protein Kinase C; Rabbits | 1991 |
Characteristics of various synthetic peptide calpain inhibitors and their application for the analysis of platelet reaction.
Topics: Arachidonic Acids; Calcium; Calpain; Collagen; Cyclooxygenase Inhibitors; Dipeptides; Humans; Inositol 1,4,5-Trisphosphate; Molecular Structure; Platelet Activation; Structure-Activity Relationship; Thrombin; Thromboxane B2; Thromboxane-A Synthase | 1991 |
Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
Topics: Animals; Blood Platelets; Calcimycin; Calpain; Cell Membrane Permeability; Dipeptides; Leupeptins; Microfilament Proteins; Papain; Peptides; Swine | 1988 |
pp60src is an endogenous substrate for calpain in human blood platelets.
Topics: Antibodies, Monoclonal; Blood Platelets; Blotting, Western; Calcimycin; Calcium; Calpain; Dimethyl Sulfoxide; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Microfilament Proteins; Molecular Weight; Platelet Aggregation; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Talin | 1993 |
Participation of calpain in protein-tyrosine phosphorylation and dephosphorylation in human blood platelets.
Topics: Blood Platelets; Calpain; Dipeptides; Humans; Phosphorylation; Protein Tyrosine Phosphatases; Vanadates | 1995 |
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.
Topics: Animals; Calpain; Cell Differentiation; Dipeptides; Nerve Growth Factors; Neurites; PC12 Cells; Rats | 1994 |
Involvement of calpain in myonephropathic metabolic syndrome (MNMS).
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Calpain; Dipeptides; Hindlimb; Male; Muscles; Rabbits; Reperfusion Injury; Rhabdomyolysis; Syndrome | 1994 |
Correlation between inhibition of cytoskeleton proteolysis and anti-vesiculation effect of calpeptin during A23187-induced activation of human platelets: are vesicles shed by filopod fragmentation?
Topics: Blood Platelets; Calcimycin; Calpain; Contractile Proteins; Cytoskeleton; Dipeptides; Filamins; Humans; Microfilament Proteins; Platelet Activation | 1994 |
Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.
Topics: Amino Acid Sequence; Animals; Calpain; Cattle; Cysteine Endopeptidases; Dipeptides; Kinetics; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Substrate Specificity | 1994 |
Role of intracellular calcium in superoxide-induced hepatocyte injury.
Topics: Animals; Calcium; Calpain; Catalase; Cell Death; Cell Survival; Cells, Cultured; Cytosol; Dipeptides; L-Lactate Dehydrogenase; Liver; Male; Microscopy, Electron, Scanning; Microscopy, Phase-Contrast; Nifedipine; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides | 1994 |
Intact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets.
Topics: Blood Coagulation; Blood Platelets; Calcimycin; Calpain; Cell Membrane; Collagen; Dipeptides; Flow Cytometry; Humans; Microscopy, Electron, Scanning; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Thrombin; Thromboplastin; von Willebrand Factor | 1993 |
The effects of calpeptin (a calpain specific inhibitor) on agonist induced microparticle formation from the platelet plasma membrane.
Topics: Antigens, Human Platelet; Blood Platelets; Calcimycin; Calcium; Calpain; Cell Membrane; Collagen; Dipeptides; Enzyme Activation; Flow Cytometry; Humans; Hydrolysis; Microfilament Proteins; Platelet Activation; Talin; Thrombin | 1993 |
Calcium-induced degradation of the inositol (1,4,5)-trisphosphate receptor/Ca(2+)-channel.
Topics: Animals; Astrocytes; Calcium; Calcium Channels; Calpain; Cell Membrane; Cerebellum; Chromatography, Affinity; Dipeptides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leupeptins; Male; Molecular Weight; Neurons; Phosphorylation; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Testis; Tumor Cells, Cultured; Vas Deferens | 1993 |
Stimulation of human platelet Ca(2+)-ATPase and Ca2+ restoration by calpain.
Topics: Aspirin; Blood Platelets; Calcimycin; Calcium; Calcium-Transporting ATPases; Calpain; Cell Compartmentation; Dipeptides; Enzyme Activation; Homeostasis; Humans; Intracellular Membranes; Leucine; Multienzyme Complexes; Platelet Activation; Stimulation, Chemical; Thrombin | 1993 |
Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture.
Topics: Animals; Blotting, Northern; Calpain; Cattle; Cell Cycle; Cell Division; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; DNA; Muscle, Smooth, Vascular | 1993 |
Cell-penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts.
Topics: Animals; Calpain; Cell Membrane Permeability; Cells, Cultured; Chick Embryo; Contractile Proteins; Dipeptides; Filamins; Membrane Fusion; Microfilament Proteins; Muscles | 1993 |
Calcium ionophore induced proteolysis and cataract: inhibition by cell permeable calpain antagonists.
Topics: Animals; Calcium; Calpain; Cataract; Cattle; Cell-Free System; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dipeptides; Eye Proteins; Intermediate Filament Proteins; Ionophores; Lens, Crystalline; Light; Rats; Rats, Wistar; Scattering, Radiation; Spectrin; Vimentin | 1996 |
The role of calpastatin (the specific calpain inhibitor) in myoblast differentiation and fusion.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cell Fusion; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Kinetics; Molecular Weight; Muscle Fibers, Skeletal; Rats | 1996 |
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain.
Topics: Blood Platelets; Calcimycin; Calpain; Cell Adhesion Molecules; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycoproteins; Humans; Immunoblotting; Ionophores; Molecular Weight; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Thrombin | 1996 |
Desmin degradation and Ca(2+)-dependent proteolysis during myoblast fusion.
Topics: Animals; Calcium; Calpain; Cell Fusion; Cells, Cultured; Desmin; Dipeptides; Intermediate Filaments; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Wistar | 1995 |
Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury.
Topics: Animals; Calcium; Calpain; Cell Membrane; Cytoskeletal Proteins; Dipeptides; Liver; Male; Microscopy, Electron; Peroxides; Rats; Rats, Wistar; Reactive Oxygen Species; tert-Butylhydroperoxide | 1996 |
Calpains are involved in phosphatidylinositol 3',4'-bisphosphate synthesis dependent on the alpha IIb beta 3 integrin engagement in thrombin-stimulated platelets.
Topics: Biological Transport; Blood Platelets; Calpain; Cytoskeleton; Dipeptides; Humans; Integrins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombin | 1997 |
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets.
Topics: Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Phosphatidylinositol Phosphates; Phosphoric Monoester Hydrolases; Platelet Activation; Substrate Specificity; Thrombin | 1997 |
Troponin T cross-linking in human apoptotic cardiomyocytes.
Topics: Acrylamide; Acrylamides; Adolescent; Adult; Apoptosis; Blotting, Western; Calcium; Calpain; Child; Dipeptides; Female; Heart; Humans; Immunohistochemistry; Male; Middle Aged; Myocardium; Troponin; Troponin T | 1997 |
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Calcimycin; Calcium-Binding Proteins; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Embryo, Mammalian; Humans; Kidney; Peptide Fragments; Transfection | 1997 |
Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells.
Topics: Antibody Specificity; Blotting, Western; Calcimycin; Calcium; Calcium-Binding Proteins; Calpain; Cells, Cultured; Chromatography, DEAE-Cellulose; Cytoskeletal Proteins; Dipeptides; Endothelium, Vascular; Enzyme Activation; Enzyme Precursors; Extracellular Space; Humans; Hydrolysis; RNA, Messenger; Umbilical Veins | 1997 |
Calpain activation in shear-induced platelet aggregation.
Topics: Calpain; Dipeptides; Enzyme Inhibitors; Humans; Platelet Activation; Platelet Aggregation; Rheology; Stress, Mechanical; Talin; Time Factors | 1997 |
Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets.
Topics: Antibodies; Blood Platelets; Calcimycin; Calpain; Cysteine Proteinase Inhibitors; Dimerization; Dipeptides; Egtazic Acid; Enzyme Activation; Enzyme Precursors; Humans; Kinetics; Macromolecular Substances; Molecular Weight; Organelles; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Substrate Specificity | 1997 |
Possible involvement of m-calpain in vascular smooth muscle cell proliferation.
Topics: Calcium-Binding Proteins; Calpain; Cell Adhesion Molecules; Cell Division; Dipeptides; DNA; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Isomerism; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Protease Inhibitors; Protein-Tyrosine Kinases | 1998 |
Calpain-mediated regulation of NMDA receptor structure and function.
Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Excitatory Amino Acid Agonists; Freezing; Glutamic Acid; Hippocampus; Ion Channel Gating; Kainic Acid; Neuronal Plasticity; Organ Culture Techniques; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1998 |
Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation.
Topics: Animals; Aplysia; Axotomy; Calcium; Calpain; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Membrane Proteins; Microscopy, Video; Nerve Regeneration; Neurites; Neurons; Spectrin; Time Factors | 1998 |
Bax cleavage is mediated by calpain during drug-induced apoptosis.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Aspartic Acid; bcl-2-Associated X Protein; Binding Sites; Calpain; Camptothecin; Cell Death; Cell Extracts; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; HL-60 Cells; Humans; Hydrolysis; Leucine; Molecular Sequence Data; Mutation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Substrate Specificity | 1998 |
Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases.
Topics: Actinin; Actins; Apoptosis; Calpain; Caspases; Cell Communication; Cells, Cultured; Cellular Senescence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dipeptides; Drug Synergism; Humans; Leupeptins; Multienzyme Complexes; Neutrophils; Phosphoproteins; Proteasome Endopeptidase Complex | 1998 |
Potential m-calpain substrates during myoblast fusion.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Extracts; Cell Fusion; Cells, Cultured; Cysteine Proteinase Inhibitors; Desmin; Dipeptides; Octoxynol; Oligonucleotides, Antisense; Rats; Rats, Wistar; Substrate Specificity; Vimentin | 1999 |
Caspase-dependent activation of calpain during drug-induced apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calpain; Caspase 3; Caspases; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; DNA Fragmentation; Enzyme Activation; HL-60 Cells; Humans; Oligopeptides | 1999 |
Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatases.
Topics: 3T3 Cells; Animals; Binding Sites; Calpain; Cell Membrane; Cross Reactions; Cysteine; Cytoskeletal Proteins; Dipeptides; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Isoenzymes; Mice; Microscopy, Fluorescence; Paxillin; Phosphoproteins; Protein Tyrosine Phosphatases; rho GTP-Binding Proteins; Structure-Activity Relationship | 1999 |
Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Calcimycin; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Hydroxyl Radical; Interferon-gamma; Ionophores; Rats; Tumor Cells, Cultured | 1999 |
Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation.
Topics: Blood Proteins; Calcium; Calpain; Dipeptides; Enzyme Activation; Humans; Ionophores; Phosphorylation; Platelet Activation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases | 1999 |
Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP).
Topics: Animals; Calcimycin; Calcium; Calpain; Dipeptides; Egtazic Acid; Female; Glutamic Acid; Ionophores; Isoenzymes; Kinetics; Molecular Weight; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Long-Evans; Thapsigargin; Transfection | 1999 |
Proteasome participates in the pathogenesis of ischemic acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Calpain; Cysteine Endopeptidases; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ischemia; Kidney; Male; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1999 |
Involvement of calpains in the destabilization of the acetylcholine receptor clusters in rat myotubes.
Topics: Animals; Animals, Newborn; Bungarotoxins; Calpain; Cells, Cultured; Dipeptides; Myofibrils; Rats; Receptors, Cholinergic | 2000 |
Calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury.
Topics: Animals; Apoptosis; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Methylprednisolone; Neurofilament Proteins; Neuroprotective Agents; Rats; Spinal Cord Injuries; Thoracic Vertebrae | 1999 |
Rat histidine decarboxylase is a substrate for m-calpain in vitro.
Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Histidine Decarboxylase; Kinetics; Peptide Fragments; Rats; Recombinant Proteins; Reticulocytes; Substrate Specificity | 2000 |
Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells.
Topics: Animals; Calpain; Caveolin 1; Caveolins; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Endothelium, Vascular; HSP90 Heat-Shock Proteins; Hypoxia; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Serine; Swine; Tyrosine | 2000 |
N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.
Topics: Apoptosis; Base Sequence; bcl-2-Associated X Protein; Calpain; Cytochrome c Group; Dipeptides; DNA Primers; Enzyme Activation; Etoposide; Humans; Hydrolysis; Jurkat Cells; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 2000 |
CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism.
Topics: 5'-Nucleotidase; Antibodies, Monoclonal; Calpain; Cell Adhesion; Cell Communication; Cell Line; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Endothelium, Vascular; Humans; Lymphocyte Function-Associated Antigen-1; Lymphocytes; Receptor Aggregation; Umbilical Veins; Up-Regulation | 2000 |
Beta1 integrin-mediated T cell adhesion and cell spreading are regulated by calpain.
Topics: Adult; Antibodies, Monoclonal; Calpain; CD3 Complex; Cell Adhesion; Cell Movement; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Fibronectins; Humans; Integrin beta1; Lymphocyte Activation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2000 |
Preload induces troponin I degradation independently of myocardial ischemia.
Topics: Animals; Blood Pressure; Calpain; Cardiac Pacing, Artificial; Cysteine Proteinase Inhibitors; Dipeptides; Heart; Hemodynamics; In Vitro Techniques; Myocardial Ischemia; Myocardium; Rats; Rats, Sprague-Dawley; Troponin I; Ventricular Function, Left | 2001 |
Disruption of focal adhesions mediates detachment during neuronal apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calpain; Caspase Inhibitors; Caspases; Cell Line; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dipeptides; Extracellular Matrix; Focal Adhesions; Neurons; Paxillin; Phosphoproteins; Proteins; Retinoblastoma-Like Protein p130; Talin | 2001 |
The role of calpain in caspase activation during etoposide induced apoptosis in T cells.
Topics: Animals; Apoptosis; Calpain; Caspases; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Etoposide; Fas Ligand Protein; Hybridomas; Leucine; Membrane Glycoproteins; Mice; T-Lymphocytes | 2001 |
Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain.
Topics: Animals; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cell Line; Cells, Cultured; Cytoplasm; Cytosol; Dipeptides; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Doublecortin-Like Kinases; Glutathione Transferase; Humans; Intracellular Signaling Peptides and Proteins; Mice; Microtubule-Associated Proteins; Microtubules; Models, Genetic; Nerve Tissue Proteins; Neurons; Neuropeptides; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Subcellular Fractions; Time Factors; Transfection | 2001 |
Crucial role of calpain in hypoxic PC12 cell death: calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-alpha and -delta.
Topics: Animals; Calcimycin; Calcium; Calpain; Caspases; Cell Death; Chelating Agents; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Egtazic Acid; Hypoxia-Ischemia, Brain; Ionophores; Isoenzymes; Nerve Degeneration; PC12 Cells; Peptide Hydrolases; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Rats | 2001 |
Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
Topics: Amino Acid Sequence; Animals; Autoantigens; Calpain; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dipeptides; Dystrophin-Associated Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Proteins; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Binding; Protein Precursors; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Secretory Vesicles; Tumor Cells, Cultured; Utrophin | 2001 |
Bruton's tyrosine kinase is a substrate of calpain in human platelets.
Topics: Agammaglobulinaemia Tyrosine Kinase; Blood Platelets; Calcimycin; Calcium; Calpain; Cells, Cultured; Dipeptides; Humans; Ionophores; Octoxynol; Protein-Tyrosine Kinases; Proteins; Thrombin; Wiskott-Aldrich Syndrome Protein | 2001 |
Beta-bungarotoxin is a potent inducer of apoptosis in cultured rat neurons by receptor-mediated internalization.
Topics: Animals; Annexin A5; Apoptosis; Bungarotoxins; Calpain; Caspase Inhibitors; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Elapid Venoms; Female; Hippocampus; In Situ Nick-End Labeling; Neurons; Neurotoxins; Phospholipases A; Pregnancy; Rats; Rats, Wistar; Receptors, Cell Surface; Signal Transduction | 2001 |
Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation.
Topics: Active Transport, Cell Nucleus; Animals; Astrocytes; Calpain; Cells, Cultured; Cysteine Endopeptidases; Dipeptides; DNA-Binding Proteins; Enzyme Induction; Gene Expression Regulation, Viral; I-kappa B Proteins; Leupeptins; Ligases; Mice; Moloney murine leukemia virus; Multienzyme Complexes; Nerve Tissue Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitin | 2001 |
Vascular smooth muscle cell spreading onto fibrinogen is regulated by calpains and phospholipase C.
Topics: Actins; Androstadienes; Animals; Calpain; Cell Adhesion; Cell Size; Chromones; Dipeptides; Enzyme Activation; Estrenes; Extracellular Matrix; Fibrinogen; Isoenzymes; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Subunits; Pyrrolidinones; Swine; Type C Phospholipases; Wortmannin | 2001 |
WASP and N-WASP in human platelets differ in sensitivity to protease calpain.
Topics: Blood Platelets; Calcium; Calpain; Cell-Free System; Dipeptides; Female; HeLa Cells; Humans; Male; Nerve Tissue Proteins; Platelet Activation; Proteins; Pseudopodia; Sensitivity and Specificity; Substrate Specificity; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein; Wiskott-Aldrich Syndrome Protein, Neuronal | 2001 |
Inhibition of proteasome activity blocks the ability of TNF alpha to down-regulate G(i) proteins and stimulate lipolysis.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Down-Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Lipolysis; Male; Multienzyme Complexes; Phenylisopropyladenosine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2001 |
Regulation of reactive oxygen species and stress fiber formation by calpeptin in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Intracellular Fluid; Mice; Phospholipases A; Phospholipases A2; Reactive Oxygen Species; rho GTP-Binding Proteins | 2002 |
Calpeptin suppresses tumor necrosis factor-alpha-induced death and accumulation of p53 in L929 mouse sarcoma cells.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Northern; Blotting, Western; Calpain; Cell Death; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Dipeptides; Genes, Dominant; Luciferases; Mice; Mutation; Nuclear Proteins; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2002 |
Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain.
Topics: Adult; Blood Platelets; Calmodulin-Binding Proteins; Calpain; Cytoskeletal Proteins; Dipeptides; Humans; In Vitro Techniques; Kinetics; Phosphorylation; Platelet Activation; Platelet Aggregation; Protein Kinase C; Recombinant Proteins; Regression Analysis; Staurosporine; Thrombin | 2002 |
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis.
Topics: Amino Acid Sequence; Apoptosis; Arginine; bcl-2 Homologous Antagonist-Killer Protein; BH3 Interacting Domain Death Agonist Protein; Calcium; Calpain; Carrier Proteins; Cathepsin L; Cathepsins; Cisplatin; Cysteine Endopeptidases; Cytochrome c Group; Dipeptides; Enzyme Activation; Glycine; Humans; Intracellular Membranes; Membrane Potentials; Membrane Proteins; Mitochondria; Molecular Sequence Data; Protein Processing, Post-Translational; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2002 |
Evidence for involvement of calpain in c-Myc proteolysis in vivo.
Topics: Animals; Blotting, Western; Calcimycin; Calcium; Calpain; Cell Line; Cell Transformation, Neoplastic; Chelating Agents; Cysteine Endopeptidases; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Ionophores; Lymphoma; Mammary Neoplasms, Experimental; Mice; Multienzyme Complexes; Mutation; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Rats | 2002 |
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments.
Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Blotting, Western; Calpain; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Endosomes; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen-Ion Concentration; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Genetic; Mutation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Time Factors; Tumor Cells, Cultured | 2002 |
Short window of opportunity for calpain induced growth cone formation after axotomy of Aplysia neurons.
Topics: Animals; Aplysia; Axotomy; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Growth Cones; Immunohistochemistry; Ionomycin; Ionophores; Nerve Regeneration; Neurons; Signal Transduction; Spectrin; Time Factors | 2002 |
Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1.
Topics: alpha-Tocopherol; Arachidonic Acid; Calcium; Calpain; Carcinoma, Hepatocellular; Culture Media; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP2E1; Cytosol; Dipeptides; Humans; Intracellular Membranes; Iron; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Permeability; Tumor Cells, Cultured | 2002 |
Constitutive nuclear factor-kappaB activity is crucial for human retinoblastoma cell viability.
Topics: Antineoplastic Agents; Apoptosis; Calpain; Caspase 3; Caspases; Cell Survival; Dipeptides; DNA; Doxorubicin; Enzyme Inhibitors; Humans; Imidazoles; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Peptides; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma; Tumor Cells, Cultured | 2002 |
Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.
Topics: Calpain; Cell Adhesion; Cyclic GMP; Dipeptides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Humans; Leupeptins; Mast Cells; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Binding; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Tumor Cells, Cultured | 2003 |
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
Topics: Amino Acid Sequence; Animals; Apolipoprotein A-I; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Calpain; Cell Line; Cell Membrane; Cells, Cultured; Chickens; Cholesterol; Cross-Linking Reagents; Dipeptides; DNA; Dose-Response Relationship, Drug; Endopeptidases; Glutamic Acid; Hepatocytes; Humans; Ligands; Lipid Metabolism; Macrophages; Mice; Molecular Sequence Data; Phospholipids; Plasmids; Proline; Serine; Threonine; Time Factors; Transfection; Up-Regulation | 2003 |
Nuclear phosphoinositide 3-kinase C2beta activation during G2/M phase of the cell cycle in HL-60 cells.
Topics: Aphidicolin; Calpain; Cell Cycle; Cell Nucleus; Chromones; Complement Activation; Complement C2; Complement C2b; Dipeptides; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Morpholines; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphatidylinositols | 2003 |
Bax cleavage implicates caspase-dependent H2O2-induced apoptosis of hepatocytes.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Precursors; Hepatocytes; Humans; Hydrogen Peroxide; Oxidants; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 2003 |
Plasmalemmal sealing of transected mammalian neurites is a gradual process mediated by Ca(2+)-regulated proteins.
Topics: Animals; Axotomy; Calcium; Calcium-Binding Proteins; Calpain; Cell Membrane; Coloring Agents; Cysteine Proteinase Inhibitors; Dipeptides; Extracellular Fluid; Membrane Fusion; Membrane Glycoproteins; Membrane Proteins; Nerve Regeneration; Nerve Tissue Proteins; Neurites; Neuroblastoma; PC12 Cells; Qa-SNARE Proteins; R-SNARE Proteins; Rats; Synaptotagmins; Tumor Cells, Cultured | 2003 |
Glutamate activates NF-kappaB through calpain in neurons.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Calpain; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dipeptides; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; I-kappa B Proteins; Immunohistochemistry; Memory; Mice; Nervous System; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2003 |
From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons.
Topics: Animals; Axons; Calpain; Dipeptides; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Genes, Tumor Suppressor; Ligation; Neurons; Phosphoproteins; Sciatic Nerve; Signal Transduction; Snails; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins | 2004 |
Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Fusion; Cell Line; Cell Movement; Clone Cells; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Dose-Response Relationship, Drug; Glucosidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mice; Muscle Fibers, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides; Phosphoproteins; Stress Fibers | 2004 |
Platelet storage under in vitro condition is associated with calcium-dependent apoptosis-like lesions and novel reorganization in platelet cytoskeleton.
Topics: Apoptosis; Blood Platelets; Blood Preservation; Calcium; Calpain; Caspases; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Cytochromes c; Cytoskeleton; Cytosol; Dipeptides; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gelsolin; Humans; Mitochondria; Phosphatidylserines; Platelet Aggregation; Protein-Tyrosine Kinases; src-Family Kinases; Thrombin | 2004 |
The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites.
Topics: Amino Acid Sequence; Base Sequence; Calpain; CD28 Antigens; CD3 Complex; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Humans; I-kappa B Proteins; Kinetics; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Oligonucleotide Probes | 2004 |
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cadaver; Calcium; Calpain; Cells, Cultured; Cytoskeleton; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurofibrils; Neurons; Phosphorylation; Signal Transduction; Spectrin; tau Proteins | 2004 |
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
Topics: Acetamides; Acetophenones; Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Benzopyrans; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Dipeptides; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Histones; Humans; Indomethacin; Kinetics; Phenanthridines; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2005 |
Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3.
Topics: Animals; Bacterial Infections; Calcium-Binding Proteins; Calpain; Caspase 3; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Oligopeptides; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2005 |
Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Amino Acid Sequence; Animals; Calcium; Calpain; Carrier Proteins; Cell Line, Tumor; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Membrane Proteins; Mice; Secretory Vesicles; Sequence Alignment; Sequence Homology, Amino Acid | 2005 |
Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion.
Topics: Animals; Calcium; Calpain; Cell Movement; Cell Proliferation; Cell Size; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Male; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction | 2005 |
The expression of calpain 1 and calpain 2 in spermatogenic cells and spermatozoa of the mouse.
Topics: Acrosome Reaction; Animals; Blotting, Western; Calpain; Dipeptides; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spermatocytes; Spermatogenesis; Spermatozoa | 2005 |
Involvement of calpain in osteoclastic bone resorption.
Topics: Actins; Aged; Bone and Bones; Bone Resorption; Calpain; Cells, Cultured; Dipeptides; Humans; Leucine; Osteoclasts; Recombinant Fusion Proteins; Talin | 2005 |
Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calpain; Caspase 3; Caspases; Cell Fusion; Cysteine Proteinase Inhibitors; Cytochromes c; Dipeptides; Glutamic Acid; Humans; Ionomycin; Ionophores; Mice; Mitochondria; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Patch-Clamp Techniques; Proto-Oncogene Proteins c-bcl-2; Rats; Spectrin; Spinal Cord | 2005 |
Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.
Topics: Animals; Arsenites; Aryl Hydrocarbon Hydroxylases; Calpain; Cells, Cultured; Cytochrome P-450 CYP3A; Dipeptides; Dose-Response Relationship, Drug; Glutathione; Heme; Hepatocytes; Male; Rats; Rats, Inbred F344; Signal Transduction | 2005 |
Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Ionomycin; Ionophores; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Wistar; Synaptosomal-Associated Protein 25; Time Factors | 2005 |
Expression and possible involvement of calpain isoforms in mammalian egg activation.
Topics: Animals; Calcium Signaling; Calpain; Dipeptides; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Ionomycin; Ionophores; Male; Meiosis; Microscopy, Confocal; Oligopeptides; Ovum; Parthenogenesis; Puromycin; Rats; Rats, Wistar; Sperm-Ovum Interactions | 2005 |
Degraded collagen induces calpain-mediated apoptosis and destruction of the X-chromosome-linked inhibitor of apoptosis (xIAP) in human vascular smooth muscle cells.
Topics: Apoptosis; Atherosclerosis; Calpain; Caspases; Cells, Cultured; Collagen; Collagenases; Dipeptides; Egtazic Acid; Enzyme Inhibitors; Extracellular Matrix; Gels; Humans; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Polymers; Recombinant Proteins; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; Dipeptides; Gene Expression; Glycoproteins; Hydrogen Peroxide; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myoblasts, Skeletal; Pepstatins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Sepsis; SKP Cullin F-Box Protein Ligases; Transfection; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2006 |
Degradation of C/EBPbeta in cultured myotubes is calpain-dependent.
Topics: Animals; Calpain; CCAAT-Enhancer-Binding Protein-beta; Cell Culture Techniques; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Glycoproteins; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein Isoforms; Rats | 2006 |
Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC.
Topics: Animals; Calcium-Binding Proteins; Calpain; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Coronary Vessels; Cytosol; Dipeptides; Endothelium, Vascular; Flavonoids; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Matrix Metalloproteinase 9; Mitochondria; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Rats; Rats, Wistar; Uncoupling Agents | 2006 |
Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Calcium; Calcium Channels; Calpain; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hypochlorous Acid; Lysosomes; Mice; Microscopy, Electron, Transmission; Neocortex; Neurons; Nifedipine; Oxidants; Tetrazolium Salts; Thiazoles; Time Factors | 2006 |
Involvement of calpains in growth factor-mediated migration.
Topics: Animals; Calcium-Binding Proteins; Calpain; Caseins; Cell Movement; Dipeptides; Gene Expression; Growth Substances; Insulin; Mice; Myoblasts; Stress Fibers | 2006 |
Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism.
Topics: Animals; Apoptosis; Calpain; Cell Culture Techniques; Dipeptides; Disease Models, Animal; DNA Fragmentation; Humans; In Situ Nick-End Labeling; Motor Neurons; Parkinsonian Disorders; Rats | 2006 |
Activation of LFA-1 by ionomycin is independent of calpain-mediated talin cleavage.
Topics: Acrylates; Androstadienes; Animals; Apoptosis; Calpain; Cell Adhesion; Cell Line, Tumor; Chromones; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hybridomas; Ionomycin; Ionophores; Lymphocyte Function-Associated Antigen-1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Receptors, Antigen, T-Cell; T-Lymphocytes; Talin; Wortmannin | 2007 |
Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain.
Topics: Blood Platelets; Calcium; Calcium-Transporting ATPases; Calpain; Cell Membrane; Collagen; Dipeptides; Enzyme Activation; Humans; Leupeptins; Platelet Activation; Thrombin | 2007 |
Calpain-dependent calpastatin cleavage regulates caspase-3 activation during apoptosis of Jurkat T cells induced by Entamoeba histolytica.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Calcium-Binding Proteins; Calpain; Caspase 3; Caspase Inhibitors; Dipeptides; DNA Cleavage; Entamoeba histolytica; Entamoebiasis; Enzyme Activation; Host-Parasite Interactions; Humans; Jurkat Cells; Parasitology; T-Lymphocytes | 2007 |
Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells.
Topics: Analysis of Variance; Animals; Calpain; Caspases; Cell Death; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Mice; Neurons; Neuroprotective Agents; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity.
Topics: Actins; Calcium; Calpain; Cell Polarity; Cells, Cultured; Chromones; Cytoskeleton; Dipeptides; Endothelial Cells; Flavonoids; Focal Adhesions; Gadolinium; Humans; Microscopy, Confocal; Morpholines; Neomycin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pseudopodia; RNA, Small Interfering; Stress, Mechanical; Talin; Vinculin | 2007 |
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.
Topics: Calcium-Binding Proteins; Calpain; Cell Line; Cytoskeletal Proteins; Dipeptides; Egtazic Acid; Endopeptidase K; Eye Proteins; Glaucoma; Glycoproteins; Humans; Ionomycin; Mutation, Missense; Protein Conformation; Protein Structure, Tertiary; Transfection | 2007 |
Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients.
Topics: Biomarkers; Calcium; Calcium Signaling; Calpain; Cytokines; Dipeptides; Enzyme Inhibitors; Female; Humans; Male; Multiple Sclerosis; Myelin Basic Protein; Neutrophils; Recurrence; Th1 Cells; Th2 Cells; Up-Regulation | 2007 |
Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence.
Topics: Androgens; Animals; Apoptosis; Calpain; Carbamates; Cell Line, Tumor; Dipeptides; Enzyme Activation; Furans; Humans; Ionomycin; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Sulfonamides; Transcriptional Activation; Transfection; Transplantation, Heterologous | 2007 |
A key role for calpains in retinal ganglion cell death.
Topics: Animals; Annexin A5; Apoptosis; Axotomy; Blotting, Western; Calcimycin; Calcium; Calpain; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Flow Cytometry; Glaucoma; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Optic Nerve; Organ Culture Techniques; Propidium; Retina; Retinal Ganglion Cells | 2007 |
Involvement of p38 MAPK-mediated signaling in the calpeptin-mediated suppression of myogenic differentiation and fusion in C2C12 cells.
Topics: Animals; Calpain; Cell Differentiation; Cell Fusion; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dipeptides; MAP Kinase Signaling System; Mice; Muscle Development; Muscle Fibers, Skeletal; Myoblasts; MyoD Protein; Myogenic Regulatory Factors; Myosin Heavy Chains; p38 Mitogen-Activated Protein Kinases; Troponin T | 2008 |
Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dipeptides; Down-Regulation; Glucose; Half-Life; Hippocampus; Insulin; Leupeptins; Male; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Mechanism of arsenic-induced neurotoxicity may be explained through cleavage of p35 to p25 by calpain.
Topics: Arsenic; Blotting, Western; Calcium; Calpain; Cyclin-Dependent Kinase 5; Cysteine Proteinase Inhibitors; Dipeptides; DNA Primers; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; HeLa Cells; Humans; Nerve Tissue Proteins; Neurotoxicity Syndromes; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2008 |
OGG1 is degraded by calpain following oxidative stress and cisplatin exposure.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Calpain; Cisplatin; Dipeptides; DNA Glycosylases; Enzyme Inhibitors; Guanine; HeLa Cells; Humans; Hydrogen Peroxide; Molecular Sequence Data; Oxidative Stress; Proteolysis | 2008 |
In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calpain; Cardiomegaly; Caspase 3; Caspase Inhibitors; Cats; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Enzyme Activation; Gelsolin; Heart Failure; Histones; In Situ Nick-End Labeling; Injections, Intravenous; Ligation; Male; Myocytes, Cardiac; Phosphorylation; Pulmonary Artery; Time Factors | 2008 |
Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein.
Topics: Acrylates; Calpain; Cells, Cultured; Dipeptides; Glycoproteins; Humans; Interleukin-1alpha; Leupeptins; Polymorphism, Genetic; RNA, Messenger | 2008 |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Biological Transport, Active; Calpain; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dipeptides; Gossypol; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Mitochondrial Membranes; Molecular Mimicry; Reactive Oxygen Species; Superoxides | 2008 |
Calpain activity contributes to the control of SNAP-25 levels in neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Coumarins; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Protein Isoforms; Rats; Seizures; Synaptosomal-Associated Protein 25; Synaptosomes | 2008 |
Involvement of calpain in the process of Jurkat T cell chemotaxis.
Topics: Calcium; Calpain; Chemokine CCL2; Chemotaxis, Leukocyte; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Fura-2; Glycoproteins; Humans; Jurkat Cells; Signal Transduction; T-Lymphocytes | 2009 |
Extranigral neurodegeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Calpain; Cell Line; Dipeptides; Humans; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Parkinsonian Disorders; Rotenone; Spinal Cord; Substantia Nigra; Uncoupling Agents | 2008 |
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Calpain; Cattle; Cells, Cultured; Cytoskeletal Proteins; Dipeptides; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Hydrogen Peroxide; Leupeptins; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Interaction Mapping; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A | 2009 |
mu-Calpain mediated cleavage of the Na+/Ca2+ exchanger in isolated mitochondria under A23187 induced Ca2+ stimulation.
Topics: Animals; Calcimycin; Calcium; Calcium-Binding Proteins; Calpain; Cattle; Dipeptides; Intracellular Membranes; Mitochondria, Muscle; Mitochondrial Membranes; Muscle, Smooth, Vascular; Phosphatidylcholines; Phospholipid Ethers; Pulmonary Artery; Sodium-Calcium Exchanger | 2009 |
Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Calpain; Cell Line, Tumor; Dipeptides; Gene Expression; Glycoproteins; Humans; Membrane Glycoproteins; Molecular Sequence Data; Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Transcriptional Activation | 2009 |
Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions.
Topics: Alternative Splicing; Antineoplastic Agents; Apoptosis; Biopsy; Calpain; Cell Line, Tumor; Cell Nucleolus; Cisplatin; Cytoplasm; Dipeptides; Dysplastic Nevus Syndrome; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Muscle Proteins; Neoplasm Metastasis; Nevus; RNA, Messenger; Skin Neoplasms | 2009 |
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
Topics: Animals; Calpain; Cell Differentiation; Dipeptides; Enzyme Inhibitors; Erythroid Cells; Female; Gene Expression Regulation; Globins; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred C57BL; Murinae; Promoter Regions, Genetic; RNA Polymerase II; Upstream Stimulatory Factors | 2009 |
Up-regulation of calcium-dependent proteolysis in human myoblasts under acute oxidative stress.
Topics: Antioxidants; Apoptosis; Calcium Signaling; Calpain; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytoplasm; Cytoplasmic Structures; Dipeptides; Flavonoids; Gene Expression; Humans; Hydrogen Peroxide; Mitochondrial Proton-Translocating ATPases; Myoblasts; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenols; Pinus; Plant Extracts; Polyphenols; Protein Carbonylation; Satellite Cells, Skeletal Muscle; Up-Regulation | 2010 |
Calpain inhibition preserves myocardial structure and function following myocardial infarction.
Topics: Animals; Apoptosis; Calpain; Cardiotonic Agents; Caspase 3; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Enzyme Activation; Injections, Intravenous; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Infarction; Myocardium; Stroke Volume; Time Factors; Ultrasonography; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Amyloid; Animals; Apoptosis; Calcium; Calpain; Cell Line, Tumor; Cell Survival; Cytosol; Diabetes Mellitus, Type 2; Dipeptides; Enzyme Activation; Female; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Male; Middle Aged; Protein Transport; Rats; Recombinant Fusion Proteins; Spectrin | 2010 |
Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum.
Topics: Animals; Blotting, Western; Calcium; Calcium-Binding Proteins; Calpain; Cattle; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Immunoprecipitation; In Vitro Techniques; Muscle, Smooth; Protein Binding; Pulmonary Artery; Sodium-Calcium Exchanger | 2010 |
Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells.
Topics: Acrylates; Antigens, CD; Apoptosis; Blotting, Western; Breast Neoplasms; Calpain; Cell Adhesion Molecules; Cell Line, Transformed; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Dipeptides; Epithelial Cells; Female; Gene Deletion; Gene Expression Regulation; Humans; Models, Biological; Mutation; Oligonucleotide Array Sequence Analysis; Protein Kinase C-delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2010 |
Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate.
Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neurotoxins; Rats; Sodium-Calcium Exchanger; Time Factors | 2010 |
Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium.
Topics: Animals; Apoptosis; Calpain; Cardiomegaly; Dipeptides; Heart Failure; Hypertrophy; Integrin beta3; Integrins; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Pressure; Signal Transduction | 2010 |
Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects.
Topics: Apoptosis; Blood Platelets; Calcimycin; Calcium Signaling; Calpain; Cell Separation; Cells, Cultured; Dipeptides; Enzyme Activation; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Phosphatidylserines; Phospholipid Transfer Proteins; Platelet Activation; Thrombin | 2010 |
Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica.
Topics: Arsenicals; Calpain; Cell Death; Dipeptides; Entamoeba histolytica; Enzyme Inhibitors; Humans; Jurkat Cells; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; T-Lymphocytes | 2010 |
Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis.
Topics: Animals; Axons; Blotting, Western; Calpain; Cell Death; Cysteine Proteinase Inhibitors; Dipeptides; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Fluorescent Antibody Technique; Gliosis; In Situ Nick-End Labeling; Inflammation; Male; Multiple Sclerosis; Nerve Tissue Proteins; Oligodendroglia; Rats; Rats, Inbred Lew; Spinal Cord; Tissue Embedding | 2010 |
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.
Topics: Calpain; Cell Line, Tumor; Cystamine; Dipeptides; GTP-Binding Proteins; Humans; I-kappa B Proteins; Neoplasms; NF-KappaB Inhibitor alpha; Proteasome Endopeptidase Complex; Protein Glutamine gamma Glutamyltransferase 2; RNA, Small Interfering; Transglutaminases; Ubiquitin | 2010 |
Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation.
Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Calpain; Cell Line; Cells, Cultured; Dipeptides; Inflammation; Interferon-gamma; Myoblasts; Rats | 2010 |
Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton.
Topics: Acrosome Reaction; Animals; Blotting, Western; Calcium-Binding Proteins; Calpain; Cytoskeleton; Dipeptides; Guinea Pigs; Leupeptins; Male; Microscopy, Electron; Spectrin; Sperm Capacitation; Spermatozoa | 2010 |
The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice.
Topics: Angiopoietin-1; Animals; Bleomycin; Calpain; Cell Line, Transformed; Cell Movement; Cell Proliferation; Collagen Type I; Dipeptides; Female; Fibroblasts; Humans; Interleukin-6; Lung; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Transforming Growth Factor beta1 | 2010 |
Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cells.
Topics: Animals; Apoptosis; Blotting, Western; Calpain; Cell Line; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Dipeptides; Histocompatibility Antigens Class I; Inflammation; Interferon-gamma; Myoblasts; Myositis; NF-kappa B; Rats; Signal Transduction; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2011 |
Calpain-mediated cleavage negatively regulates the expression level of ABCG1.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Calpain; Dipeptides; HEK293 Cells; Humans; Lipoproteins; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL | 2011 |
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Calpain; Camptothecin; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Dipeptides; DNA Damage; DNA-Binding Proteins; Humans; Morpholines; Neuroblastoma; Protein Serine-Threonine Kinases; Purines; Pyrones; Roscovitine; Tumor Suppressor Proteins | 2011 |
P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Calcium; Calpain; Cell Line, Tumor; Cisplatin; Cysteine Proteinase Inhibitors; Dipeptides; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Humans; Immunoprecipitation; Intracellular Space; Nuclear Proteins; Ovarian Neoplasms; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Tumor Protein p73; Tumor Suppressor Proteins | 2011 |
Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.
Topics: Acute Disease; Animals; Apoptosis; Blotting, Western; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Gene Expression Regulation; In Situ Nick-End Labeling; Injections, Intraperitoneal; Male; Optic Neuritis; Rats; Rats, Inbred Lew; Retinal Ganglion Cells; RNA; Treatment Outcome | 2011 |
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Butadienes; Calpain; Caspase 3; Caspase Inhibitors; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Cytoprotection; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Gestational Age; In Situ Nick-End Labeling; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Neuroprotective Agents; Nitriles; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Signal Transduction; Spectrin; Time Factors | 2011 |
Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Blotting, Western; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Hybrid Cells; In Situ Nick-End Labeling; Mice; Motor Neurons; Rotenone; Spinal Cord; Uncoupling Agents | 2011 |
Calpains are involved in Entamoeba histolytica-induced death of HT-29 colonic epithelial cells.
Topics: Calpain; Cell Death; Cell Line; Cell Survival; Dipeptides; Entamoeba histolytica; Epithelial Cells; Gene Knockdown Techniques; Humans | 2011 |
Proteomic study of calpeptin-induced differentiation on calpain-interacting proteins of C2C12 myoblast.
Topics: Animals; Calpain; Cell Differentiation; Dipeptides; Gene Expression Regulation, Developmental; Mice; Muscle Development; Myoblasts; Protein Interaction Maps; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Cell Line, Tumor; Cells, Cultured; Dipeptides; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Pregnancy | 2012 |
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
Topics: Animals; Astrocytes; Biomarkers; Calcium; Calcium-Binding Proteins; Calpain; Cell Count; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Proliferation; Dipeptides; Gene Silencing; Intermediate Filament Proteins; Mice; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Phenotype; Tubulin | 2012 |
Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes.
Topics: Apoptosis; Calcium-Binding Proteins; Calpain; Caspase 1; Caspase Inhibitors; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Humans; Keratinocytes; Methicillin-Resistant Staphylococcus aureus; Mutation; Signal Transduction; Soft Tissue Infections; Staphylococcal Infections; Staphylococcal Skin Infections; Virulence Factors | 2012 |
The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner.
Topics: Calcium; Calpain; Cell Line, Tumor; Cell Movement; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Neoplasm Invasiveness; Protein Tyrosine Phosphatases, Non-Receptor; Proteolysis | 2012 |
Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca(2+) homeostasis and preventing calpain activation.
Topics: Androstadienes; Animals; Anti-Arrhythmia Agents; Benzylisoquinolines; Calcium; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Male; Muscle Proteins; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Wortmannin | 2012 |
Calpain inhibition attenuated morphological and molecular changes in skeletal muscle of experimental allergic encephalomyelitis rats.
Topics: Animals; Apoptosis; Blotting, Western; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Encephalomyelitis, Autoimmune, Experimental; In Situ Nick-End Labeling; Male; Muscle, Skeletal; Rats; Rats, Inbred Lew | 2012 |
Effects of inhibitors on the synergistic interaction between calpain and caspase-3 during post-mortem aging of chicken meat.
Topics: Animals; Calcium-Binding Proteins; Calpain; Caspase 3; Caspase Inhibitors; Chickens; Dipeptides; Muscle, Skeletal; Oligopeptides; Poultry; Protease Inhibitors | 2012 |
N-terminal cleavage fragment of focal adhesion kinase is required to activate the survival signalling pathway in cultured myoblasts under oxidative stress.
Topics: Animals; Apoptosis; Blotting, Western; Calpain; Cell Adhesion; Cell Survival; Cells, Cultured; Dipeptides; Focal Adhesion Protein-Tyrosine Kinases; Mice; Myoblasts; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2012 |
Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats.
Topics: Animals; Apoptosis; Aquaporin 4; Calcium; Calpain; Cyclooxygenase 2; Cytokines; Dipeptides; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glycoproteins; Male; Molecular Weight; Myelin Basic Protein; NF-kappa B; Nitric Oxide Synthase Type II; Optic Nerve; Optic Neuritis; Rats; Rats, Inbred Lew; Signal Transduction | 2013 |
Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets.
Topics: Animals; Anoctamins; Blood Platelets; Calcium Signaling; Calpain; CD36 Antigens; Cell Membrane; Crotalid Venoms; Dipeptides; Humans; Lectins, C-Type; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Phosphatidylserines; Phospholipid Transfer Proteins; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Structure, Quaternary; Proteolysis; src-Family Kinases; Talin; Thrombin | 2013 |
T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Calpain; Cell Line; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Down-Regulation; Leupeptins; Mice; Mice, Knockout; Proto-Oncogene Proteins c-cbl; Receptors, Antigen, T-Cell; T-Lymphocytes; Ubiquitination; Wiskott-Aldrich Syndrome Protein | 2013 |
Clostridium perfringens beta-toxin induces necrostatin-inhibitable, calpain-dependent necrosis in primary porcine endothelial cells.
Topics: Acrylates; Animals; Bacterial Toxins; Blotting, Western; Calcium; Calpain; Cell Membrane; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; DNA Fragmentation; Endothelial Cells; Flow Cytometry; HMGB1 Protein; Imidazoles; Indoles; Intracellular Space; Ion Transport; L-Lactate Dehydrogenase; Microscopy, Electron, Transmission; Necrosis; Potassium; Swine | 2013 |
Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis.
Topics: Amyloid beta-Protein Precursor; Animals; Calcium; Calpain; Chlorides; Dipeptides; Disease Models, Animal; Ectodysplasins; Encephalomyelitis, Autoimmune, Experimental; Female; Magnetic Resonance Imaging; Manganese Compounds; Myelin-Oligodendrocyte Glycoprotein; Nerve Degeneration; Neuroprostanes; Optic Nerve; Optic Neuritis; Rats; Retina; Retinal Ganglion Cells; Time Factors | 2013 |
Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Arsenite Transporting ATPases; Calpain; Cell Death; Cell Line; Dipeptides; Dopaminergic Neurons; Electrophoresis, Gel, Two-Dimensional; Glycine; Infarction, Middle Cerebral Artery; Ionomycin; Peripherins; Proteome; Proteomics; Rats; Rats, Sprague-Dawley | 2013 |
Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Calpain; Cell Survival; Cells, Cultured; Cysteine; Dipeptides; Endoplasmic Reticulum Stress; Hippocampus; Leupeptins; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Spectrin | 2014 |
Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression.
Topics: Androgens; Blotting, Western; Calpain; Dipeptides; Filamins; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Male; Microscopy, Confocal; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2014 |
The role of calpain-myosin 9-Rab7b pathway in mediating the expression of Toll-like receptor 4 in platelets: a novel mechanism involved in α-granules trafficking.
Topics: Blood Platelets; Blotting, Western; Calpain; Cells, Cultured; Dipeptides; Estrenes; Flow Cytometry; Gallic Acid; Humans; Immunoprecipitation; Male; Myosins; Protein Transport; Pyrrolidinones; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Signal Transduction; Thrombin; Toll-Like Receptor 4 | 2014 |
High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Alzheimer Disease; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Extracellular Space; Glutamic Acid; Humans; Intracellular Space; Nicotine; Nicotinic Agonists; Phosphocreatine; Phosphoenolpyruvate; Rotenone; Uncoupling Agents | 2014 |
IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice.
Topics: Animals; Brain; Brain Ischemia; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Infarction, Middle Cerebral Artery; Interleukin-17; Male; Mice, Inbred C57BL; Mice, Knockout; Proteolysis; Recombinant Proteins; Reperfusion Injury; Time Factors; TRPC Cation Channels; TRPC6 Cation Channel | 2014 |
[The effect of calpeptin on injury and atrophy of diaphragm under mechanical ventilation in rats].
Topics: Animals; Atrophy; Calpain; Diaphragm; Dipeptides; Disease Models, Animal; Male; Myosin Heavy Chains; Rats; Rats, Sprague-Dawley; Respiration, Artificial | 2014 |
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Topics: Adaptive Immunity; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Calpain; Cell Cycle Checkpoints; Cells, Cultured; Colitis; Cytosol; Dextran Sulfate; Dipeptides; Epithelial Cells; Female; HMGB1 Protein; Humans; Intestinal Mucosa; Male; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Proteolysis | 2015 |
Prion protein fragment (106-126) induces prothrombotic state by raising platelet intracellular calcium and microparticle release.
Topics: Blood Coagulation; Blood Platelets; Calcium; Calcium Signaling; Calpain; Cell-Derived Microparticles; Cells, Cultured; Cytoskeleton; Dipeptides; Humans; Intracellular Space; Peptide Fragments; Platelet Activation; Prion Diseases; Prions; Proteolysis; Talin; Thrombosis | 2015 |
Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
Topics: Aldosterone; Angiotensin II; Animals; Calpain; Cattle; Cell Line, Tumor; Cells, Cultured; Dipeptides; Humans; Hydrocortisone; Zona Glomerulosa | 2015 |
Chronic intermittent ethanol induced axon and myelin degeneration is attenuated by calpain inhibition.
Topics: Administration, Inhalation; Alcoholism; Animals; Axons; Brain; Calpain; Central Nervous System Depressants; Dipeptides; Disease Models, Animal; Ethanol; Glycoproteins; Male; Mice, Inbred C57BL; Myelin Sheath; Nerve Degeneration; Neuroprotective Agents; Spinal Cord; Substance Withdrawal Syndrome | 2015 |
Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice.
Topics: Animals; Astrocytes; Calpain; Dipeptides; Dopaminergic Neurons; Gait Disorders, Neurologic; Inflammation; Lymphocyte Subsets; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Nerve Tissue Proteins; Parkinsonian Disorders; Spinal Cord; Substantia Nigra | 2015 |
Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane.
Topics: Animals; Astrocytes; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Large-Conductance Calcium-Activated Potassium Channels; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Patch-Clamp Techniques; Rats, Wistar | 2016 |
Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia-reperfusion.
Topics: Animals; Blotting, Western; Calcium; Calpain; Dipeptides; Female; Humans; Male; Middle Aged; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Young Adult | 2015 |
Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Calpain; Cell Line, Tumor; Cell Proliferation; Cell-Derived Microparticles; Dipeptides; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Taxoids; Treatment Outcome | 2015 |
Neuroprotective Effect of Calpeptin on Acrylamide-Induced Neuropathy in Rats.
Topics: Acrylamide; Animals; Behavior, Animal; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Female; Gait Disorders, Neurologic; Injections, Intraperitoneal; Neurofilament Proteins; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Spinal Cord | 2015 |
Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.
Topics: Antibiotics, Antineoplastic; Blotting, Western; Calpain; Cell Line, Tumor; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Ion Transport; Magnesium; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; TRPM Cation Channels | 2015 |
Multiple pathways regulate Cten in colorectal cancer without a Tensin switch.
Topics: Calpain; Colorectal Neoplasms; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; Humans; Microfilament Proteins; Protein Stability; Proto-Oncogene Proteins p21(ras); Signal Transduction; STAT3 Transcription Factor; Tensins; Transfection | 2015 |
Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.
Topics: Animals; Calpain; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dipeptides; Disease Models, Animal; Gene Expression; Humans; Mice; Pancreatic Neoplasms; Pancreatic Stellate Cells; RNA, Messenger; Stromal Cells; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Neuron-microglia interaction induced bi-directional cytotoxicity associated with calpain activation.
Topics: Animals; Calpain; Carbamates; Cell Survival; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Gene Knockdown Techniques; Humans; Inflammation; Microglia; Motor Neurons; Multiple Sclerosis; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Th1 Cells; Th17 Cells | 2016 |
Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma.
Topics: Airway Remodeling; Animals; Asthma; Calpain; Cell Proliferation; Collagen Type I; Cytokines; Dipeptides; Disease Models, Animal; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Knockout; Muscle, Smooth; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Signal Transduction | 2017 |
Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia.
Topics: Animals; Aplysia; Association Learning; Calpain; Conditioning, Operant; Cysteine Proteinase Inhibitors; Dipeptides; Memory | 2017 |
Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus.
Topics: Adult; Biomarkers; Blood Glucose; Blood Platelets; Calpain; Case-Control Studies; Circulating MicroRNA; Cross-Sectional Studies; Cysteine Proteinase Inhibitors; DEAD-box RNA Helicases; Diabetes Mellitus, Type 2; Dipeptides; Down-Regulation; Female; Humans; K562 Cells; Male; Megakaryocytes; Middle Aged; P-Selectin; Platelet Activation; Receptors, Purinergic P2Y12; Ribonuclease III; Time Factors; Transfection; Up-Regulation | 2017 |
The MARCKS protein amount is differently regulated by calpain during toxic effects of methylmercury between SH-SY5Y and EA.hy926 cells.
Topics: Calcium; Calpain; Cell Line; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Dipeptides; Gene Knockdown Techniques; Humans; Intracellular Signaling Peptides and Proteins; Methylmercury Compounds; Myristoylated Alanine-Rich C Kinase Substrate; Proteolysis; Signal Transduction | 2017 |
Inhibition of angiotensin II and calpain attenuates pleural fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bleomycin; Calpain; Carbon; Cell Line; Collagen Type I; Dipeptides; Disease Models, Animal; Fibrosis; Humans; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pleural Diseases | 2018 |
Calpeptin is neuroprotective against acrylamide-induced neuropathy in rats.
Topics: Acrylamide; Animals; Calpain; Dipeptides; Female; Motor Neuron Disease; Neuroprotective Agents; Rats; Rats, Wistar | 2018 |
Blocking the Cleavage of Filamin A by Calpain Inhibitor Decreases Tumor Cell Growth.
Topics: Animals; Calpain; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dipeptides; Filamins; Glycoproteins; Humans; Male; Mice; Neoplasms; Proteolysis | 2018 |
Calpain inhibition attenuates bleomycin-induced pulmonary fibrosis via switching the development of epithelial-mesenchymal transition.
Topics: Actins; Animals; Basic Helix-Loop-Helix Transcription Factors; Bleomycin; Cadherins; Calpain; Collagen Type I; Dipeptides; Epithelial-Mesenchymal Transition; Homeodomain Proteins; Humans; Male; Mice, Inbred C57BL; Pulmonary Fibrosis | 2018 |
The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcineurin; Calcium; Calpain; Case-Control Studies; Cells, Cultured; Dipeptides; Disease Models, Animal; Gene Expression Regulation; Glomerulosclerosis, Focal Segmental; Humans; Male; Podocytes; Proteinuria; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reference Values; Signal Transduction; TRPC Cation Channels; TRPC6 Cation Channel; Up-Regulation | 2018 |
Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain/IκBα signaling in mice and BEAS-2B cells.
Topics: Animals; Calpain; Cell Line; Dipeptides; Humans; Male; Mice; Mice, Inbred BALB C; NF-KappaB Inhibitor alpha; Pneumonia; Signal Transduction; Tobacco Smoke Pollution | 2018 |
The Role of Calpain and Proteasomes in the Degradation of Carbonylated Neuronal Cytoskeletal Proteins in Acute Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Calpain; Cytoskeleton; Dipeptides; Encephalomyelitis, Autoimmune, Experimental; Injections, Spinal; Male; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Carbonylation; Proteolysis; Rats; Rats, Inbred Lew | 2018 |
Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice.
Topics: Animals; Calpain; Cells, Cultured; Dipeptides; Gene Knockdown Techniques; Glycoproteins; Membrane Potentials; Mice, Transgenic; Motor Activity; Motor Neurons; Muscular Atrophy, Spinal; Mutation; Nerve Degeneration; Neurites; Phenotype; Potassium; Spinal Cord; Survival of Motor Neuron 1 Protein | 2019 |
Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Female; Muscular Atrophy; Rotator Cuff Injuries; Sarcolemma; Sheep | 2018 |
The Dual Role of HIV-1 gp120 V3 Loop-Induced Autophagy in the Survival and Apoptosis of the Primary Rat Hippocampal Neurons.
Topics: Adenine; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; HIV Envelope Protein gp120; HIV-1; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Kinase Inhibitors; Rats, Sprague-Dawley | 2019 |
Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation.
Topics: Algorithms; Calcimycin; Calpain; Cell Line, Tumor; Dipeptides; Humans; MAP Kinase Kinase Kinase 2; Mutagenesis, Site-Directed; Phosphorylation; Protein Serine-Threonine Kinases; Protein Stability; Proteolysis; RNA Interference; RNA, Small Interfering; Temperature | 2019 |
Calpain suppresses cell growth and invasion of glioblastoma multiforme by producing the cleavage of filamin A.
Topics: Biomarkers, Tumor; Brain Neoplasms; Calpain; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dipeptides; Filamins; Glioblastoma; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Prognosis; Temozolomide; Tissue Inhibitor of Metalloproteinase-2 | 2020 |
Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Calpain; Cytoskeletal Proteins; Depression; Dipeptides; Disks Large Homolog 4 Protein; Gene Expression; Glycoproteins; Hippocampus; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Presynaptic Terminals | 2020 |
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.
Topics: Animals; Calcium-Binding Proteins; Calpain; Carrier Proteins; Cell Differentiation; Cell Line; Cell Survival; Cells, Cultured; Dipeptides; Disease Models, Animal; Fibroblasts; Humans; Induced Pluripotent Stem Cells; Mice; Mice, Mutant Strains; Microfilament Proteins; Microtubule-Associated Proteins; Motor Neurons; Muscular Atrophy, Spinal; Proteolysis; Spinal Cord; Survival of Motor Neuron 1 Protein | 2020 |
Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening.
Topics: Animals; Apoptosis; Brain; Calcium; Calcium Signaling; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Isoenzymes; Leupeptins; Male; Mitochondria; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Molecular Weight; Muscle Proteins; Phosphorylation; Protein Transport; Rats | 2021 |
Calpain Inhibitor Calpeptin Improves Alzheimer's Disease-Like Cognitive Impairments and Pathologies in a Diabetes Mellitus Rat Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calpain; Cognitive Dysfunction; Diabetes Mellitus; Dipeptides; Glucose; Glycoproteins; Rats | 2022 |
Therapeutic use of calpeptin in COVID-19 infection.
Topics: Calpain; COVID-19 Drug Treatment; Humans; Post-Acute COVID-19 Syndrome; SARS-CoV-2 | 2022 |
Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Calpain; Cyclic AMP Response Element-Binding Protein; Flavonoids; Glutamic Acid; Membrane Proteins; Neuroprotective Agents; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats | 2023 |