Page last updated: 2024-09-03

calpain inhibitor 2 and lactacystin

calpain inhibitor 2 has been researched along with lactacystin in 11 studies

Compound Research Comparison

Studies
(calpain inhibitor 2)
Trials
(calpain inhibitor 2)
Recent Studies (post-2010)
(calpain inhibitor 2)
Studies
(lactacystin)
Trials
(lactacystin)
Recent Studies (post-2010) (lactacystin)
680139201155

Protein Interaction Comparison

ProteinTaxonomycalpain inhibitor 2 (IC50)lactacystin (IC50)
Proteasome subunit beta type-11Homo sapiens (human)0.259
Proteasome subunit alpha type-7Homo sapiens (human)0.259
Proteasome subunit beta type-1Homo sapiens (human)0.259
Proteasome subunit alpha type-1Homo sapiens (human)0.259
Proteasome subunit alpha type-2Homo sapiens (human)0.259
Proteasome subunit alpha type-3Homo sapiens (human)0.259
Proteasome subunit alpha type-4Homo sapiens (human)0.259
Proteasome subunit beta type-8Homo sapiens (human)0.259
Proteasome subunit beta type-9Homo sapiens (human)0.259
Proteasome subunit alpha type-5Homo sapiens (human)0.259
Proteasome subunit beta type-4Homo sapiens (human)0.259
Proteasome subunit beta type-6Homo sapiens (human)0.259
Proteasome subunit beta type-5Homo sapiens (human)1.2498
Proteasome subunit beta type-10Homo sapiens (human)0.259
Proteasome subunit beta type-3Homo sapiens (human)0.259
Proteasome subunit beta type-2Homo sapiens (human)1.7545
Proteasome subunit alpha type-6Homo sapiens (human)0.259
Splicing factor 3B subunit 3Homo sapiens (human)3.481
Proteasome subunit alpha-type 8Homo sapiens (human)0.259
Proteasome subunit beta type-7Homo sapiens (human)0.259

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (36.36)18.2507
2000's5 (45.45)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, CH; Ho, P; Huang, L; Lee, KH; Qian, K; Yu, D1
Chen, CH; Dang, Z; Ho, P; Huang, L; Lee, KH; Lin, A; Soroka, D1
Chen, CH; Huang, L; Hung, HY; Kim, SY; Lee, KH; Qian, K1
Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB1
Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T1
Elce, J; Forsberg, NE; Huang, J; Ichihara, A; Ou, BR; Tanaka, K; Ueda, Y; Wang, MC1
Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN1
Bohrn, E; Herceg, Z; Wang, ZQ; Wesierska-Gadek, J; Wurzer, G1
An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB1
Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T1
Emi, Y; Ikushiro, S; Iyanagi, T; Omura, S1

Other Studies

11 other study(ies) available for calpain inhibitor 2 and lactacystin

ArticleYear
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Esterification; Glycyrrhetinic Acid; Humans; Protease Inhibitors; Proteasome Inhibitors; Structure-Activity Relationship

2008
Synthesis and proteasome inhibition of lithocholic acid derivatives.
    Bioorganic & medicinal chemistry letters, 2011, Apr-01, Volume: 21, Issue:7

    Topics: HeLa Cells; Humans; Kinetics; Lithocholic Acid; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors

2011
New betulinic acid derivatives as potent proteasome inhibitors.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Antineoplastic Agents; Betulinic Acid; Chymotrypsin; Cysteine Proteinase Inhibitors; Drug Design; Inflammation; Molecular Structure; Molecular Targeted Therapy; Neoplasms; Pentacyclic Triterpenes; Proteasome Inhibitors; Signal Transduction; Structure-Activity Relationship; Triterpenes

2011
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
    Cell, 1995, Oct-06, Volume: 83, Issue:1

    Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins

1995
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
    Oncogene, 1997, Aug-14, Volume: 15, Issue:7

    Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins

1997
Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation.
    The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Calpain; Carrier Proteins; Cell Differentiation; Cell Line; Creatine Kinase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Iron-Binding Proteins; Multienzyme Complexes; Muscles; Myogenin; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Transferrin-Binding Proteins

1998
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
    Cardiovascular research, 1998, Volume: 38, Issue:3

    Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats

1998
Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors.
    Journal of cellular biochemistry, 2000, Jun-12, Volume: 78, Issue:4

    Topics: Acetylcysteine; Animals; Cell Line; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Fibroblasts; Fluorescent Dyes; Humans; Immunoblotting; Indoles; Leupeptins; Mice; Mice, Knockout; Microscopy, Fluorescence; Multienzyme Complexes; Oligopeptides; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteins; Time Factors; Tumor Suppressor Protein p53

2000
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
    Leukemia, 2000, Volume: 14, Issue:7

    Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells

2000
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
    Journal of neurobiology, 2001, Volume: 48, Issue:2

    Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta

2001
Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.
    Archives of biochemistry and biophysics, 2002, Sep-15, Volume: 405, Issue:2

    Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glucuronosyltransferase; Glycoproteins; Half-Life; Hepatocytes; Leupeptins; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Mutation; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Gunn; Rats, Wistar; RNA, Messenger; Subcellular Fractions

2002