calpain inhibitor 2 has been researched along with calpain in 36 studies
| Studies (calpain inhibitor 2) | Trials (calpain inhibitor 2) | Recent Studies (post-2010) (calpain inhibitor 2) | Studies (calpain) | Trials (calpain) | Recent Studies (post-2010) (calpain) |
|---|---|---|---|---|---|
| 68 | 0 | 13 | 7,019 | 25 | 2,422 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 20 (55.56) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L; Wang, M; Zimmerman, UJ | 1 |
| Banik, N; Figueiredo-Pereira, ME; Wilk, S | 1 |
| Ekwunife, FS; Liu, L; Nelson, JB; Wang, M; Zimmerman, UJ | 1 |
| Clifton, GL; Hayes, RL; Kampfl, A; Liu, J; Posmantur, R; Siman, R; Zhao, X | 1 |
| Bloemendal, H; Broers, JL; Gerards, WL; Henfling, ME; Machiels, BM; Ramaekers, FC; Schutte, B | 1 |
| Henderson, CE; Henzel, WJ; Pettmann, B; Sensenbrenner, M; Villa, PG | 1 |
| Anyane-Yeboa, K; Chan, SO; Chiu, FC; Ko, L; Runko, E | 1 |
| Elce, J; Forsberg, NE; Huang, J; Ichihara, A; Ou, BR; Tanaka, K; Ueda, Y; Wang, MC | 1 |
| Droin, N; Eymin, B; Haugg, M; Munsch, B; Solary, E; Sordet, O; Van de Craen, M; Vandenabeele, P | 1 |
| An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB | 1 |
| Bell, GI; Burant, CF; Cox, NJ; Currie, KP; Fox, AP; Hanis, CL; Hansen, PA; Horikawa, Y; Lee, JP; Ostrega, DM; Otani, K; Pan, CY; Polonsky, KS; Pugh, W; Sreenan, SK; Zhou, YP | 1 |
| Qian, W; Shichi, H | 1 |
| Kang, WK; Lee, I; Park, C | 1 |
| Anderson, DK; Angileri, FF; Arcadi, F; Bausano, B; Bramanti, P; Costa, C; Day, AL; DeFord, SM; Germanò, A; Hayes, RL; Pike, BR; Zhao, X | 1 |
| Brustis, JJ; Cottin, P; Dargelos, E; Dedieu, S; Grise, F; Mazères, G; Poussard, S | 1 |
| Araújo Couto, L; Blanco Martinez, AM; Hokoç, JN; Sampaio Narciso, M | 1 |
| Hara, S; Okazaki, M; Sakaue, M | 1 |
| Ben-Aharon, I; Ben-Yosef, D; Haim, K; Shalgi, R | 1 |
| Calle, Y; Carragher, NO; Jones, GE; Thrasher, AJ | 1 |
| Cribb, AE; Muruganandan, S | 1 |
| Chau, GY; Chau, YP; Chien, CL; Don, MJ; Kung, HN; Lu, KS | 1 |
| Chu, S; Gong, YT; Li, WM; Li, Y; Sheng, L; Xue, HJ; Zhang, L | 1 |
| Choe, H; Choi, J; Haam, J; Kim, D; Yoon, S | 1 |
| Aggeli, IK; Beis, I; Gaitanaki, C | 1 |
| Garcia, JA; Khan, SA; Kumar, GK; Nanduri, J; Peng, YJ; Prabhakar, NR; Souvannakitti, D; Wang, N; Yuan, G | 1 |
| Luong, MW; Rabkin, SW | 1 |
| Goette, A; Lendeckel, U | 1 |
| Campbell, M; Farrar, GJ; Gobbo, OL; Humphries, MM; Humphries, P; Kenna, PF; Kerskens, C; Kiang, AS; Nguyen, AT; Ni Dhubhghaill, S; Tam, LC | 1 |
| Dong, DL; Fu, SB; Gong, YT; Gong, ZH; Li, WM; Li, Y; Sheng, L; Tan, XY; Xue, HJ; Yang, BF | 1 |
| Abrenica, B; Cook, T; Gilchrist, JS; Pierce, GN; Rashidkhani, B | 1 |
| Ali, MA; Fan, X; Holt, A; Schulz, R; Stepanko, A | 1 |
| Buettner, FF; Konze, SA; Kuss, AW; Möller, H; Olmer, R; Pich, A; Schröder, A; van Diepen, L; Weißmann, R; Zweigerdt, R | 1 |
| Deng, Y; Feng, S; Liu, W; Xu, B; Xu, ZF; Yang, TY | 1 |
| Balcerska, A; Bryl, E; Frąckowiak, JE; Henc, I; Mikosik, A; Płoszyńska, A; Ruckemann-Dziurdzińska, K; Witkowski, JM | 1 |
| Baudry, M; Bi, X; Dayal, S; Hurtado, A; Lee, M; Liu, Y; Lopez, D; Wang, Y | 1 |
| Bryl, E; Daca, A; Frąckowiak, J; Fulop, T; Hellmann, A; Mikosik, A; Mital, A; Puchalska, Z; Witkowski, JM; Łopatniuk, P | 1 |
36 other study(ies) available for calpain inhibitor 2 and calpain
| Article | Year |
|---|---|
Inhibition of secretion from isolated rat alveolar epithelial type II cells by the cell permeant calpain inhibitor II (N-acetyl-leucyl-leucyl-methioninal).
Topics: Amino Acid Sequence; Animals; Calcium; Calpain; Cell Membrane Permeability; Epithelial Cells; Epithelium; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Oligopeptides; Phosphatidylcholines; Protease Inhibitors; Pulmonary Alveoli; Rats | 1995 |
Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.
Topics: Amino Acid Sequence; Animals; Calpain; Cattle; Cysteine Endopeptidases; Dipeptides; Kinetics; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Substrate Specificity | 1994 |
Secretagogue-induced proteolysis of cAMP-dependent protein kinase in intact rat alveolar epithelial type II cells.
Topics: Adrenergic beta-Agonists; Animals; Calpain; Cell Separation; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cysteine Proteinase Inhibitors; Epithelial Cells; Epithelium; Oligopeptides; Phosphorylation; Pulmonary Alveoli; Rats; Terbutaline | 1996 |
A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Calpain; Cerebral Cortex; Cysteine Proteinase Inhibitors; Functional Laterality; Male; Neurofilament Proteins; Oligopeptides; Rats; Rats, Sprague-Dawley; Spectrin | 1997 |
Detailed analysis of cell cycle kinetics upon proteasome inhibition.
Topics: Animals; Bromodeoxyuridine; Calpain; Cell Cycle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycoproteins; Humans; Kinetics; Leupeptins; Microscopy, Phase-Contrast; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1997 |
Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis.
Topics: Actins; Amino Acid Sequence; Animals; Apoptosis; Calpain; Chick Embryo; Ciliary Body; Ciliary Neurotrophic Factor; Cysteine Proteinase Inhibitors; DNA Fragmentation; Ganglia, Parasympathetic; Glycoproteins; Hydrolysis; Molecular Sequence Data; Nerve Tissue Proteins; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Sequence Analysis | 1998 |
Calcium ionophore-induced degradation of neurofilament and cell death in MSN neuroblastoma cells.
Topics: Calcimycin; Calpain; Carrier Proteins; Cell Death; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Intermediate Filament Proteins; Leupeptins; Nerve Tissue Proteins; Neuroblastoma; Neurofibrils; Oligopeptides; Tumor Cells, Cultured | 1998 |
Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Calpain; Carrier Proteins; Cell Differentiation; Cell Line; Creatine Kinase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Iron-Binding Proteins; Multienzyme Complexes; Muscles; Myogenin; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Transferrin-Binding Proteins | 1998 |
Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Base Sequence; Calpain; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leukemia; Leupeptins; Microtubule-Associated Proteins; Molecular Sequence Data; Mutation; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Protein Serine-Threonine Kinases; Thimerosal; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 1999 |
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Calpains play a role in insulin secretion and action.
Topics: Adipocytes; Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Deoxyglucose; Electric Conductivity; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Membranes; Islets of Langerhans; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NADP; Oligopeptides; Osmolar Concentration; Time Factors | 2001 |
Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation.
Topics: Animals; Anterior Chamber; Calcium; Calpain; Cataract; Epithelial Cells; Glycoproteins; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Naphthoquinones; Oligopeptides | 2001 |
Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.
Topics: Apoptosis; Calpain; Cell Cycle Proteins; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Oligopeptides; Prostatic Neoplasms; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Systemic administration of a calpain inhibitor reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat.
Topics: Animals; Behavioral Symptoms; Blood-Brain Barrier; Body Weight; Calpain; Male; Motor Skills; Oligopeptides; Permeability; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage | 2002 |
Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Fusion; Cell Line; Cell Movement; Clone Cells; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Dose-Response Relationship, Drug; Glucosidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mice; Muscle Fibers, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides; Phosphoproteins; Stress Fibers | 2004 |
Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers.
Topics: Animals; Axons; Calpain; Cysteine Proteinase Inhibitors; Nerve Crush; Nerve Degeneration; Nerve Fibers, Myelinated; Oligopeptides; Opossums; Optic Nerve | 2004 |
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Topics: Animals; Apoptosis; Calcium; Calpain; Carrier Proteins; Cell Survival; Cerebellar Cortex; Cysteine Proteinase Inhibitors; Enzyme Activation; Immunoblotting; Methylmercury Compounds; Microfilament Proteins; Nerve Tissue Proteins; Neurons; Oligopeptides; Rats; Rats, Wistar; Spectrometry, Fluorescence; tau Proteins | 2005 |
Expression and possible involvement of calpain isoforms in mammalian egg activation.
Topics: Animals; Calcium Signaling; Calpain; Dipeptides; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Ionomycin; Ionophores; Male; Meiosis; Microscopy, Confocal; Oligopeptides; Ovum; Parthenogenesis; Puromycin; Rats; Rats, Wistar; Sperm-Ovum Interactions | 2005 |
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.
Topics: Actin Cytoskeleton; Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Line; Cell Membrane Structures; Cell Movement; Cells, Cultured; Dendritic Cells; Enzyme Activation; Focal Adhesion Kinase 2; Glycoproteins; Mice; Mice, Inbred Strains; Oligopeptides; Peptide Fragments; Structure-Activity Relationship; Talin; Wiskott-Aldrich Syndrome Protein | 2006 |
Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells.
Topics: Acrylates; Animals; Calpain; Cell Death; Cell Nucleus; Cell Shape; Cell Survival; Chromatin; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycoproteins; Heat-Shock Proteins; Immunoblotting; Iodoacetamide; L-Lactate Dehydrogenase; LLC-PK1 Cells; Membrane Proteins; Oligopeptides; Swine; tert-Butylhydroperoxide; Thapsigargin; Time Factors; Tunicamycin; Vitamin K 3 | 2006 |
Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.
Topics: Angiogenesis Inhibitors; Apoptosis; Arginine; Calcium; Calpain; Caspases; Cell Line; Cell Survival; Chelating Agents; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Leupeptins; Membrane Potential, Mitochondrial; Naphthoquinones; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oligopeptides; Signal Transduction; Time Factors | 2007 |
[Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs].
Topics: Animals; Atrial Fibrillation; Blotting, Western; Calpain; Disease Models, Animal; Dogs; Heart; Injections, Intravenous; Myocardial Contraction; Myocardium; Myosins; Oligopeptides; Random Allocation | 2007 |
Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cadherins; Calpain; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Down-Regulation; Enzyme Inhibitors; Glycoproteins; Membrane Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Okadaic Acid; Oligopeptides; Rats | 2007 |
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.
Topics: alpha-Crystallin B Chain; Animals; Apoptosis; Calcium Signaling; Calpain; Caspase 3; Cell Line; Cell Nucleus; Cytochromes c; Egtazic Acid; Hydrogen Peroxide; Leupeptins; Myocytes, Cardiac; Oligopeptides; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Poly(ADP-ribose) Polymerases; Protein Transport; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Time Factors; Tubulin | 2008 |
Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.
Topics: Animals; Apnea; Autonomic Nervous System; Basic Helix-Loop-Helix Transcription Factors; Calcium Signaling; Calcium-Binding Proteins; Calpain; Cell Hypoxia; Down-Regulation; Enzyme Activation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Oligopeptides; Oxidative Stress; PC12 Cells; Protein Binding; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2009 |
Verapamil but not calpain or creatine alters arsenate-induced cardiac cell death.
Topics: Animals; Arsenates; Calpain; Cell Death; Chick Embryo; Creatine; Dose-Response Relationship, Drug; Myocytes, Cardiac; Oligopeptides; Verapamil | 2009 |
Calpain in atrial fibrillation: friend or foe?: editorial to: "anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model" by Yue Li et al.
Topics: Animals; Apoptosis; Atrial Fibrillation; Calpain; Caspase 7; Dogs; Myocytes, Cardiac; Oligopeptides | 2009 |
An experimental platform for systemic drug delivery to the retina.
Topics: Animals; Blood-Retinal Barrier; Calpain; Claudin-5; Cysteine Proteinase Inhibitors; Disease Models, Animal; Drug Delivery Systems; Electroretinography; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Retina; Retinitis Pigmentosa; RNA Interference; RNA, Small Interfering | 2009 |
Anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Atrial Fibrillation; Blotting, Western; Body Weight; Calpain; Caspase 3; Dogs; Immunohistochemistry; In Situ Nick-End Labeling; Myocardial Contraction; Myocytes, Cardiac; Oligopeptides; Organ Size; Protease Inhibitors; RNA, Messenger | 2009 |
Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion.
Topics: Animals; Autolysis; Blotting, Western; Calpain; Cell Fractionation; Cytosol; Disease Models, Animal; Dogs; Electrophoresis, Polyacrylamide Gel; Intracellular Membranes; Leupeptins; Male; Muscle, Skeletal; Myocardial Reperfusion Injury; Myocardium; Oligopeptides; Rabbits; Rats; Rats, Sprague-Dawley | 2010 |
Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity.
Topics: Acrylates; Calpain; Catalysis; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Gelatin; Humans; Inhibitory Concentration 50; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Oligopeptides; Phenyl Ethers; Troponin I | 2012 |
Cleavage of E-cadherin and β-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells.
Topics: beta Catenin; Cadherins; Calpain; Cell Adhesion; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Glycoproteins; High-Throughput Nucleotide Sequencing; Humans; Isotope Labeling; Oligopeptides; Pluripotent Stem Cells; Proteomics; Sequence Analysis, RNA; Wnt Signaling Pathway | 2014 |
Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures.
Topics: alpha-Synuclein; Animals; Calpain; Gene Expression; Manganese; Oligopeptides; Protein Multimerization; Proteolysis; Rats, Wistar; Tissue Culture Techniques | 2015 |
Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.
Topics: Adolescent; Age Factors; Apoptosis; B-Lymphocytes; Blast Crisis; Calpain; Cell Proliferation; Child; Child, Preschool; Female; Humans; Infant; Male; Neoplasm Proteins; Oligopeptides; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Calpain; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuroprotective Agents; Oligopeptides; Recovery of Function | 2018 |
Excessive amount and activity of μ-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease.
Topics: Aged; Aged, 80 and over; Apoptosis; B-Lymphocytes; Calpain; Case-Control Studies; Caspase 3; Caspase 9; Cells, Cultured; Disease Progression; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; ZAP-70 Protein-Tyrosine Kinase | 2020 |