calpain has been researched along with 3-7-dioxolanosta-8-24-dien-26-oic-acid* in 1 studies
1 other study(ies) available for calpain and 3-7-dioxolanosta-8-24-dien-26-oic-acid
| Article | Year |
|---|---|
Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells.
Though the current therapies are effective at clearing an early stage prostate cancer, they often fail to treat late-stage metastatic disease. We aimed to investigate the molecular mechanisms underlying the anticancer effects of a natural triterpenoid, ganoderic acid DM (GA-DM), on two human prostate cancer cell lines: the androgen-independent prostate carcinoma (PC-3), and androgen-sensitive prostate adenocarcinoma (LNCaP). Cell viability assay showed that GA-DM was relatively more toxic to LNCaP cells than to PC-3 cells (IC Topics: Antineoplastic Agents; Apoptosis; Autophagy; Calpain; Caspase 3; Cell Cycle Checkpoints; Cell Survival; DNA Fragmentation; Endoplasmic Reticulum Stress; Humans; Male; PC-3 Cells; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Triterpenes; Tumor Suppressor Protein p53 | 2019 |