calpain has been researched along with 1-2-naphthoquinone* in 1 studies
1 other study(ies) available for calpain and 1-2-naphthoquinone
| Article | Year |
|---|---|
Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation.
N-acetyl-p-benzoquinone imine (NAPQI), a semiquinone metabolite of acetaminophen, produces cataract in mice. Naphthalene is biotransformed to the cataractogenic metabolite 1,2-naphthoquinone (NQ). Intracameral injection of NAPQI elicits a rapid increase in free intracellular Ca2+ in the lens epithelium and calpain activation before lens opacification begins. In order to test whether the cellular response is a common feature of quinone-induced cataracts, we injected in this work 1,2-naphthoquinone (NA) in the anterior chamber of mouse eye and followed cellular responses in the lens prior to opacity development. A marked rise in free intracellular Ca2+ in the lens epithelium and concurrent activation of calpain were observed within 1 hr after NQ injection preceding lens opacity development. These results support the suggestion that Ca2+ release and calpain activation are involved in the mechanism of quinone-induced cataractogenesis. Topics: Animals; Anterior Chamber; Calcium; Calpain; Cataract; Epithelial Cells; Glycoproteins; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Naphthoquinones; Oligopeptides | 2001 |