callipeltin-b and quinone-methide

callipeltin-b has been researched along with quinone-methide* in 1 studies

Other Studies

1 other study(ies) available for callipeltin-b and quinone-methide

Article	Year
Synthesis and cytotoxicity of desmethoxycallipeltin B: lack of a quinone methide for the cytotoxicity of callipeltin B. Bioorganic & medicinal chemistry letters, 2007, Sep-15, Volume: 17, Issue:18 The desmethoxy analogue of the cytotoxic, cyclic depsipeptide callipeltin B was synthesized to evaluate the role of its beta-MeOTyr residue. The IC(50) of desmethoxycallipeltin B, in which the beta-MeOTyr residue was replaced by d-Tyr, against HeLa cells was found to be 128+/-10 microM in an MTT assay, compared to 98+/-5 microM for the natural product itself. The roughly comparable cytotoxicities suggest that the cytotoxicity of callipeltin B does not arise through the formation of a quinone methide intermediate. Topics: Antineoplastic Agents; Indolequinones; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2007

Article

Year

Synthesis and cytotoxicity of desmethoxycallipeltin B: lack of a quinone methide for the cytotoxicity of callipeltin B.

Bioorganic & medicinal chemistry letters, 2007, Sep-15, Volume: 17, Issue:18

The desmethoxy analogue of the cytotoxic, cyclic depsipeptide callipeltin B was synthesized to evaluate the role of its beta-MeOTyr residue. The IC(50) of desmethoxycallipeltin B, in which the beta-MeOTyr residue was replaced by d-Tyr, against HeLa cells was found to be 128+/-10 microM in an MTT assay, compared to 98+/-5 microM for the natural product itself. The roughly comparable cytotoxicities suggest that the cytotoxicity of callipeltin B does not arise through the formation of a quinone methide intermediate.

Topics: Antineoplastic Agents; Indolequinones; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2007