calcitonin and pyridine

calcitonin has been researched along with pyridine* in 1 studies

Other Studies

1 other study(ies) available for calcitonin and pyridine

Article	Year
[Synthesis of a partially purified fragment of salmon calcitonin 1-16 using a phenylhydrazide protective group]. Bioorganicheskaia khimiia, 1993, Volume: 19, Issue:2 The partially protected fragment Boc-Cys(Acm)-Ser(Bu(t))-Asn-Leu-Ser(Bu(t))-Thr (Bu(t))-Cys(Acm)-Val-Leu-Gly-Lys(Boc)-Leu-Ser(Bu(t))-Gln-Glu(OBu(t ))- Leu-OH of salmon calcitonin was synthesized by the segment condensation in solution. Segments were synthesized by the DCC/HOBt method in solution with phenylhydrazide as a semipermanent protecting group for the carboxyl function of the C-terminal residue. The phenylhydrazide group was removed by oxidation with air oxygen catalyzed by copper pyridine complexes under mild conditions. The segments were then condensed by the DCC/HOBt method according to the scheme (6 + 3) + (3 + 4). The proposed scheme makes it possible to product the partially protected fragment 1-16 of salmon calcitonin on the gram scale. Topics: Amino Acid Sequence; Animals; Calcitonin; Catalysis; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Peptide Fragments; Phenylhydrazines; Pyridines	1993

Article

Year

[Synthesis of a partially purified fragment of salmon calcitonin 1-16 using a phenylhydrazide protective group].

Bioorganicheskaia khimiia, 1993, Volume: 19, Issue:2

The partially protected fragment Boc-Cys(Acm)-Ser(Bu(t))-Asn-Leu-Ser(Bu(t))-Thr (Bu(t))-Cys(Acm)-Val-Leu-Gly-Lys(Boc)-Leu-Ser(Bu(t))-Gln-Glu(OBu(t ))- Leu-OH of salmon calcitonin was synthesized by the segment condensation in solution. Segments were synthesized by the DCC/HOBt method in solution with phenylhydrazide as a semipermanent protecting group for the carboxyl function of the C-terminal residue. The phenylhydrazide group was removed by oxidation with air oxygen catalyzed by copper pyridine complexes under mild conditions. The segments were then condensed by the DCC/HOBt method according to the scheme (6 + 3) + (3 + 4). The proposed scheme makes it possible to product the partially protected fragment 1-16 of salmon calcitonin on the gram scale.

Topics: Amino Acid Sequence; Animals; Calcitonin; Catalysis; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Peptide Fragments; Phenylhydrazines; Pyridines

1993