calcimycin and pidotimod

calcimycin has been researched along with pidotimod* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and pidotimod

Article	Year
Immunomodulating activity of pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Experiments were performed to analyze the effect of the immunomodulating agent pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) on the mouse splenic proliferative response to Con-A and IL-2, natural killer (NK) cell activity and thymocyte apoptosis. The results indicate that in vivo treatment with pidotimod (200 mg/kg i.p. for 5 days) causes a significant increase in the proliferative response to mitogens (including Con-A and IL-2) and the cytotoxic activity mediated by NK cells. Pidotimod inhibits in vitro thymocyte apoptosis caused by other inducing agents such as protein kinase C activator 12-O-tetradecanoyl-phorbol-13-acetate, Ca(++)-ionophore A23187, genistein and interleukin-2 (IL-2). Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcimycin; Cell Division; DNA; Female; Flow Cytometry; Killer Cells, Natural; Male; Mice; Mice, Inbred C3H; Mitogens; Protein-Tyrosine Kinases; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Tissue Plasminogen Activator; Tumor Cells, Cultured	1994

Article

Year

Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A

Experiments were performed to analyze the effect of the immunomodulating agent pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) on the mouse splenic proliferative response to Con-A and IL-2, natural killer (NK) cell activity and thymocyte apoptosis. The results indicate that in vivo treatment with pidotimod (200 mg/kg i.p. for 5 days) causes a significant increase in the proliferative response to mitogens (including Con-A and IL-2) and the cytotoxic activity mediated by NK cells. Pidotimod inhibits in vitro thymocyte apoptosis caused by other inducing agents such as protein kinase C activator 12-O-tetradecanoyl-phorbol-13-acetate, Ca(++)-ionophore A23187, genistein and interleukin-2 (IL-2).

Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcimycin; Cell Division; DNA; Female; Flow Cytometry; Killer Cells, Natural; Male; Mice; Mice, Inbred C3H; Mitogens; Protein-Tyrosine Kinases; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Tissue Plasminogen Activator; Tumor Cells, Cultured

1994