calcimycin and phenothiazine

calcimycin has been researched along with phenothiazine* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and phenothiazine

ArticleYear
The role of calmodulin on Ca2+ -dependent K+ transport regulation in the human red cell.
    Biochimica et biophysica acta, 1986, Aug-07, Volume: 860, Issue:1

    Several lipophilic calmodulin antagonists (phenotiazines, butyrophenones and diphenylbutylpiperidines) inhibited Ca2+-induced loss of KC1 from human red cells. However, the Ki values for this effect did not bear good correlation with the Ki values reported for well-known calmodulin-dependent systems. In addition, the inhibition was strongly dependent on the haematocrit and valinomycin-induced KC1 fluxes were also affected. Added calmodulin did not have any effect on Ca2+-dependent 86Rb uptake by inside-out vesicles derived from red cell membranes whereas stimulation of Ca2+-dependent ATPase was apparent. Lipophilic anticalmodulins at high doses had all kinds of effects on 86Rb uptake by inside-out vesicles: increase, decrease or no change of the fraction of activated vesicles reached at submaximal Ca2+ concentrations, with or without modification of the relative rate of 86Rb uptake. The hydrophylic compound 48/80 decreased the fraction of activated vesicles reached at submaximal Ca2+ concentrations without affecting the relative rate of 86Rb uptake, but this effect took place only at concentrations 10-fold higher than the reported Ki for calmodulin-dependent systems. These results suggest that Ca2+-dependent K+ channels of red cells are not regulated by calmodulin.

    Topics: Biological Transport; Butyrophenones; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Erythrocyte Membrane; Humans; In Vitro Techniques; p-Methoxy-N-methylphenethylamine; Phenothiazines; Piperidines; Potassium; Rubidium; Valinomycin

1986