calcimycin has been researched along with hydroquinone* in 3 studies
1 review(s) available for calcimycin and hydroquinone
| Article | Year |
|---|---|
The role of endothelium in the responses of vascular smooth muscle to drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Catechols; Endothelium; Histamine; Hydroquinones; Hypoxia; Masoprocol; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandins; Quinacrine; Serotonin; Substance P; Thrombin | 1984 |
2 other study(ies) available for calcimycin and hydroquinone
| Article | Year |
|---|---|
Phenols inhibit prostaglandin E2 synthesis in A23187-stimulated human whole blood and modify the ratio of arachidonic acid metabolites.
We have previously demonstrated that the phenolic compounds catechol, hydroquinone, and phenol increase the prostaglandin (PG) E2/leukotriene (LT) B4 ratio in human polymorphonuclear leukocytes (PMNs), while resorcinol has the opposite effect. However, in human whole blood phenols have a different effect on the thromboxane (TX) B2/LT ratio than in PMNs on the PGE2/LTB4 ratio. To establish whether the discrepancy between the results of our previous studies is due to different indicators of prostaglandin H synthase activity in PMNs (PGE2) and in whole blood (TXB2), we measured the effect of phenols on PGE2 synthesis in whole blood. The phenols only inhibited PGE2 synthesis (IC50 values for resorcinol, catechol, hydroquinone, and phenol of 10 microM, 10 microM, 60 microM and 700 microM, respectively). No significant stimulatory activity was seen as earlier in PMNs. Thus, the effect of phenols on PGE2 synthesis in whole blood is different from that in PMNs, although their order of potency to inhibit PGE2 synthesis is the same. Topics: Arachidonic Acid; Calcimycin; Catechols; Dinoprostone; Humans; Hydroquinones; Neutrophils; Phenol; Phenols; Prostaglandin-Endoperoxide Synthases; Resorcinols; Thromboxane B2 | 1995 |
Uncertain role of endothelium-derived relaxing factor in mesenteric arterioles of cats and rabbits.
Experiments were undertaken in the mesentery of anesthetized cats and rabbits to investigate whether the endothelium of resistance vessels mediates relaxation of arteriolar smooth muscle through the endothelium-derived relaxing factor(s) (EDRF). The microcirculation was visualized by transillumination using intravital microscopy and a Millikan camera. Pictures were obtained at a rate of 400 frames/second. Arteriolar mean diameter and surface area were computer calculated. The animals were divided in two groups. In one group of experiments, EDRF was inactivated by direct injection of hydroquinone (HQ) into the superior mesenteric artery and the second group served as control. Norepinephrine or vasopressin constricted while acetylcholine or Ca-ionophore A23187 dilated arterioles. Hydroquinone failed to inhibit arteriolar dilation in situ. The effect of HQ on the endothelium in situ was ascertained by bioassay of superior mesenteric artery strips. Our results cast doubt on the role of EDRF in the dilation of mesenteric arterioles in felines and rabbits. Topics: Acetylcholine; Animals; Biological Products; Calcimycin; Cats; Hydroquinones; Image Processing, Computer-Assisted; In Vitro Techniques; Mesenteric Arteries; Nitric Oxide; Norepinephrine; Rabbits; Vasodilation | 1988 |