calcimycin has been researched along with geranylgeraniol* in 1 studies
1 other study(ies) available for calcimycin and geranylgeraniol
| Article | Year |
|---|---|
Effects of Simvastatin on RBL-2H3 Cell Degranulation.
Hypercholesterolemia is a major complication of arteriosclerosis. Mast cells in arteriosclerosis plaques induce inflammatory reactions and promote arterial sclerosis. In this study, we evaluated the pharmacological effects of simvastatin (SV)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors on the degranulation of rat basophilic leukemia (RBL)-2H3 cells, which are commonly used as mast cell models. SV significantly decreased the degranulation induced by three types of stimulation: antigen antibody reaction (Ag-Ab), thapsigargin (Tg) serosal endoplasmic reticulum calcium ATPase (SERCA) inhibitor, and A23187 calcium ionophore. SV had a stronger inhibitory effect on degranulation induced by Ag-Ab stimulation than the other two stimulations. However, SV did not inhibit increase of intracellular Ca Topics: Animals; Calcimycin; Calcium; Cell Degranulation; Mast Cells; Rats; Signal Transduction; Simvastatin | 2023 |