calcimycin and dicarbine

calcimycin has been researched along with dicarbine* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and dicarbine

Article	Year
Effect of stobadine on human stimulated polymorphonuclear leukocytes. Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:2 The effect of stobadine (0.1-100 microM) on human polymorphonuclear (PMN) leukocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine, a specific receptor activator, or with the calcium ionophore, A-23187 (receptor bypassing stimulus) was investigated with respect to: i) superoxide generation, ii) beta-glucuronidase release and iii) 3[H]-arachidonic acid liberation. Stobadine was found to exert an inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine but not on A-23187-stimulated PMN leukocytes. The effect was more intensive on superoxide generation and beta-glucuronidase release than on 3[H]-arachidonic acid liberation. These results indicate that the inhibitory effect of stobadine is most probably via a mechanism dependent on signal transduction across the plasma membrane. This effect may occur through inhibition of arachidonate signal transduction through a regulatory G-protein. Topics: Antioxidants; Arachidonic Acid; Calcimycin; Carbolines; Glucuronidase; Humans; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Stimulation, Chemical; Superoxides	1999

Article

Year

Effect of stobadine on human stimulated polymorphonuclear leukocytes.

Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:2

The effect of stobadine (0.1-100 microM) on human polymorphonuclear (PMN) leukocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine, a specific receptor activator, or with the calcium ionophore, A-23187 (receptor bypassing stimulus) was investigated with respect to: i) superoxide generation, ii) beta-glucuronidase release and iii) 3[H]-arachidonic acid liberation. Stobadine was found to exert an inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine but not on A-23187-stimulated PMN leukocytes. The effect was more intensive on superoxide generation and beta-glucuronidase release than on 3[H]-arachidonic acid liberation. These results indicate that the inhibitory effect of stobadine is most probably via a mechanism dependent on signal transduction across the plasma membrane. This effect may occur through inhibition of arachidonate signal transduction through a regulatory G-protein.

Topics: Antioxidants; Arachidonic Acid; Calcimycin; Carbolines; Glucuronidase; Humans; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Stimulation, Chemical; Superoxides

1999