calcimycin has been researched along with dicarbine* in 1 studies
1 other study(ies) available for calcimycin and dicarbine
Article | Year |
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Effect of stobadine on human stimulated polymorphonuclear leukocytes.
The effect of stobadine (0.1-100 microM) on human polymorphonuclear (PMN) leukocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine, a specific receptor activator, or with the calcium ionophore, A-23187 (receptor bypassing stimulus) was investigated with respect to: i) superoxide generation, ii) beta-glucuronidase release and iii) 3[H]-arachidonic acid liberation. Stobadine was found to exert an inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine but not on A-23187-stimulated PMN leukocytes. The effect was more intensive on superoxide generation and beta-glucuronidase release than on 3[H]-arachidonic acid liberation. These results indicate that the inhibitory effect of stobadine is most probably via a mechanism dependent on signal transduction across the plasma membrane. This effect may occur through inhibition of arachidonate signal transduction through a regulatory G-protein. Topics: Antioxidants; Arachidonic Acid; Calcimycin; Carbolines; Glucuronidase; Humans; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Stimulation, Chemical; Superoxides | 1999 |