calcimycin and beta-casomorphin-7

We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.

Topics: Animals; Calcimycin; Carnosine; Endorphins; Histamine Release; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Peritoneal Cavity; Rats; Rats, Wistar; Taurine