calcimycin and benzothiazole

calcimycin has been researched along with benzothiazole* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and benzothiazole

Article	Year
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid. Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17 A novel series of N-[(2-benzothiazolylthio)alkyl]-N'-hydroxyurea derivatives (9-25) was synthesized and evaluated for biological activity as inhibitors of 5-lipoxygenase both in vivo (mouse zymosan peritonitis assay) and in vitro (Ca2+ ionophore-stimulated human peripheral blood leukocyte model). The compounds of this series were based on the corresponding hydroxamic acid derivatives (1, 3, 4, and 5) which were moderately active in vitro but inactive in vivo. A number of compounds in the hydroxyurea series exhibited oral activity for 5-lipoxygenase inhibition. Results of studies relating structure to in vivo and in vitro 5-lipoxygenase activity are reported. Topics: Animals; Benzothiazoles; Calcimycin; Dogs; Humans; Hydroxamic Acids; Hydroxyurea; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Methemoglobin; Mice; Molecular Structure; Peritonitis; SRS-A; Structure-Activity Relationship; Thiazoles	1992

Article

Year

Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.

Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17

A novel series of N-[(2-benzothiazolylthio)alkyl]-N'-hydroxyurea derivatives (9-25) was synthesized and evaluated for biological activity as inhibitors of 5-lipoxygenase both in vivo (mouse zymosan peritonitis assay) and in vitro (Ca2+ ionophore-stimulated human peripheral blood leukocyte model). The compounds of this series were based on the corresponding hydroxamic acid derivatives (1, 3, 4, and 5) which were moderately active in vitro but inactive in vivo. A number of compounds in the hydroxyurea series exhibited oral activity for 5-lipoxygenase inhibition. Results of studies relating structure to in vivo and in vitro 5-lipoxygenase activity are reported.

Topics: Animals; Benzothiazoles; Calcimycin; Dogs; Humans; Hydroxamic Acids; Hydroxyurea; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Methemoglobin; Mice; Molecular Structure; Peritonitis; SRS-A; Structure-Activity Relationship; Thiazoles

1992