calcimycin and azodicarbonamide

calcimycin has been researched along with azodicarbonamide* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and azodicarbonamide

Article	Year
Azodicarbonamide as a new T cell immunosuppressant: synergy with cyclosporin A. Clinical immunology (Orlando, Fla.), 2001, Volume: 100, Issue:1 We recently demonstrated that azodicarbonamide is an immunosuppressive compound that inhibits calcium mobilization in T lymphocytes. In this study, we show that azodicarbonamide prevents the progression of human CD4+ T lymphocytes into the G1 phase of the cell cycle, inhibits their blastogenesis, down-regulates their membrane expression of CD25 and CD69, and decreases their transcription of cytokine genes. Addition of the calcium ionophore A23187 completely restores T cell proliferation in the presence of azodicarbonamide. Furthermore, azodicarbonamide synergizes with cyclosporin A to inhibit CD4+ T cell proliferation. In conclusion, the immunosuppressive action of azodicarbonamide is mainly related to its effect on the calcium mobilization machinery and is synergistic with that of calcineurin inhibitors. Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Azo Compounds; Calcimycin; Calcineurin Inhibitors; Calcium Signaling; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Down-Regulation; Drug Synergism; G1 Phase; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-2; Ionophores; Lectins, C-Type; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Receptors, Interleukin-2; Transcription Factors	2001

Article

Year

Azodicarbonamide as a new T cell immunosuppressant: synergy with cyclosporin A.

Clinical immunology (Orlando, Fla.), 2001, Volume: 100, Issue:1

We recently demonstrated that azodicarbonamide is an immunosuppressive compound that inhibits calcium mobilization in T lymphocytes. In this study, we show that azodicarbonamide prevents the progression of human CD4+ T lymphocytes into the G1 phase of the cell cycle, inhibits their blastogenesis, down-regulates their membrane expression of CD25 and CD69, and decreases their transcription of cytokine genes. Addition of the calcium ionophore A23187 completely restores T cell proliferation in the presence of azodicarbonamide. Furthermore, azodicarbonamide synergizes with cyclosporin A to inhibit CD4+ T cell proliferation. In conclusion, the immunosuppressive action of azodicarbonamide is mainly related to its effect on the calcium mobilization machinery and is synergistic with that of calcineurin inhibitors.

Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Azo Compounds; Calcimycin; Calcineurin Inhibitors; Calcium Signaling; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Down-Regulation; Drug Synergism; G1 Phase; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-2; Ionophores; Lectins, C-Type; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Receptors, Interleukin-2; Transcription Factors

2001