calcimycin and 7-hydroxystaurosporine

calcimycin has been researched along with 7-hydroxystaurosporine* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and 7-hydroxystaurosporine

Article	Year
Effect of a potent selective protein kinase C inhibitor on histamine release from rat mast cells. Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:2 3,10-Dihydroxy-10-[(dimethylamino)methyl]-2,3,9,10,11,12-hexahydro-9- methyl-9,12-epoxy-1H-diindolo[1,2,3-fg-3',2',1'-k1]pyrrolo[3,4- l][1,6]benzodiazocin-1-one (UCN-01) strongly and dose-dependently inhibited histamine release from rat peritoneal mast cells that was induced by anti-immunoglobulin E (anti-IgE), calcimycin (A 23187), and 1,2-o-tetradecanoyl-13-acetate (TPA). The concentrations of UCN-01 required for 50% inhibition of histamine release induced by anti-IgE, A23187, and TPA were 1.5, 2.7, and 1.4 nM, respectively; these values are similar to those for 50% inhibition of protein kinase C. These results suggest possible participation cells induced by various secretagogues. Topics: Alkaloids; Animals; Calcimycin; Histamine Release; Immunoglobulin E; In Vitro Techniques; Mast Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate	1993

Article

Year

Effect of a potent selective protein kinase C inhibitor on histamine release from rat mast cells.

Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:2

3,10-Dihydroxy-10-[(dimethylamino)methyl]-2,3,9,10,11,12-hexahydro-9- methyl-9,12-epoxy-1H-diindolo[1,2,3-fg-3',2',1'-k1]pyrrolo[3,4- l][1,6]benzodiazocin-1-one (UCN-01) strongly and dose-dependently inhibited histamine release from rat peritoneal mast cells that was induced by anti-immunoglobulin E (anti-IgE), calcimycin (A 23187), and 1,2-o-tetradecanoyl-13-acetate (TPA). The concentrations of UCN-01 required for 50% inhibition of histamine release induced by anti-IgE, A23187, and TPA were 1.5, 2.7, and 1.4 nM, respectively; these values are similar to those for 50% inhibition of protein kinase C. These results suggest possible participation cells induced by various secretagogues.

Topics: Alkaloids; Animals; Calcimycin; Histamine Release; Immunoglobulin E; In Vitro Techniques; Mast Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate

1993