calcimycin and 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one

calcimycin has been researched along with 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one

ArticleYear
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
    The American journal of Chinese medicine, 1998, Volume: 26, Issue:3-4

    Inhibitory mechanism of the water extract of Scutellariae Radix on prostaglandin E2 (PGE2) release was examined in C6 rat glioma cells. Scutellariae Radix reduced a Ca2+ ionophore A23187-induced PGE2 release by inhibition of arachidonic acid (AA) liberation. Sho-saiko-to and San'o-shashin-to, which contain Scutellariae Radix, also inhibited PGE2 release. A23187 caused phosphorylation of mitrogen-activated protein kinase (MAPK), resulting in activation of cytosolic phospholipase A2 (cPLA2). Scutellariae Radix and baicalein inhibited the phosphorylation of MAPK. Baicalein, but not baicalin, inhibited A23187-induced PGE2 release. These results suggest that baicalein in Scutellariae Radix reduces AA liberation through the inhibition of the MAPK-cPLA2 pathway.

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavanones; Flavonoids; Glioma; Ionophores; Molecular Sequence Data; Phosphorylation; Prostaglandin Antagonists; Rats; Tumor Cells, Cultured

1998