calcimycin has been researched along with 5-(biotinamido)pentylamine* in 1 studies
1 other study(ies) available for calcimycin and 5-(biotinamido)pentylamine
| Article | Year |
|---|---|
Transglutaminase 1 stabilizes beta-actin in endothelial cells correlating with a stabilization of intercellular junctions.
Microvascular endothelial monolayers from mouse myocardium become resistant to various barrier-compromising stimuli correlating with the expression of transglutaminase 1 (TGase1) and its translocation towards cellular junctions. In contrast, endothelial monolayers from mouse lung microvessels do not express TGase1 and remain sensitive to barrier-compromising stimuli corresponding to the known in vivo sensitivity of the lung microvasculature. Using the TGase-substrate 5-(biotinamido)-pentylamine, specific TGase inhibitors and RNAi, one target protein of TGase1 in endothelial cells was found to be beta-actin, suggesting that tissue-specific stabilization of the cortical actin filament network by intracellular TGase1 activity may play a role in controlling barrier properties of endothelial monolayers. Topics: Actins; Amines; Animals; Biotin; Cadaverine; Calcimycin; Calcium; Capillary Permeability; Cell Line; Coronary Vessels; Endothelial Cells; Enzyme Inhibitors; Intercellular Junctions; Ionophores; Lung; Mice; Microcirculation; Protein Transport; RNA Interference; RNA, Small Interfering; Transglutaminases | 2007 |