calcimycin and 13-azaprostanoic-acid

calcimycin has been researched along with 13-azaprostanoic-acid* in 1 studies

Other Studies

1 other study(ies) available for calcimycin and 13-azaprostanoic-acid

Article	Year
Enhancement of collagen-induced phosphoinositide turnover by thromboxane A2 analogue through Ca2+ mobilization in human platelets. FEBS letters, 1985, Nov-11, Volume: 192, Issue:1 In human washed platelets, collagen-induced phosphoinositide turnover was inhibited by indomethacin, an inhibitor of thromboxane A2 (TXA2) formation, particularly at lower doses of collagen. This inhibition was counteracted by the addition of 9,11-epithio-11,12-methano-TXA2 (STA2), a stable analogue of TXA2 as well as by the Ca2+ ionophore A23187. STA2 and A23187 did not stimulate phosphoinositide turnover markedly, but significantly increased cytoplasmic free Ca2+ concentrations. The actions of STA2 were blocked by 13-azaprostanoic acid, a TXA2 receptor antagonist. The results suggest that TXA2 is generated during the action of collagen and increases cytoplasmic free Ca2+ which then stimulates phosphoinositide turnover in cooperation with collagen. Topics: Blood Platelets; Calcimycin; Calcium; Collagen; Cytoplasm; Humans; Indomethacin; Myosins; Phosphatidic Acids; Phosphatidylinositols; Phosphorylation; Prostanoic Acids; Thromboxane A2	1985

Article

Year

Enhancement of collagen-induced phosphoinositide turnover by thromboxane A2 analogue through Ca2+ mobilization in human platelets.

FEBS letters, 1985, Nov-11, Volume: 192, Issue:1

In human washed platelets, collagen-induced phosphoinositide turnover was inhibited by indomethacin, an inhibitor of thromboxane A2 (TXA2) formation, particularly at lower doses of collagen. This inhibition was counteracted by the addition of 9,11-epithio-11,12-methano-TXA2 (STA2), a stable analogue of TXA2 as well as by the Ca2+ ionophore A23187. STA2 and A23187 did not stimulate phosphoinositide turnover markedly, but significantly increased cytoplasmic free Ca2+ concentrations. The actions of STA2 were blocked by 13-azaprostanoic acid, a TXA2 receptor antagonist. The results suggest that TXA2 is generated during the action of collagen and increases cytoplasmic free Ca2+ which then stimulates phosphoinositide turnover in cooperation with collagen.

Topics: Blood Platelets; Calcimycin; Calcium; Collagen; Cytoplasm; Humans; Indomethacin; Myosins; Phosphatidic Acids; Phosphatidylinositols; Phosphorylation; Prostanoic Acids; Thromboxane A2

1985