calcimycin and 1--methylascorbigen

Ascorbigens are indole-containing derivatives of L-ascorbic acid, some of them (e.g., 1'-methylascorbigen) have been shown to inhibit growth of experimental murine tumors. Immunomodulating properties of 1'-methylascorbigen correlated with its antitumor effect. The immunomodulating action of 1'-methylascorbigen is to a marked degree based on its influence on arachidonic acid metabolism in murine spleen cells. A single injection of 50 mg/kg 1'-methylascorbigen leads to pronounced and immediate increase of the cells' ability to produce PGE2 and LTB4 (up to 550% and 460%, correspondingly). Till the tenth day after injection the levels of these metabolites of arachidonic acid were double that of the control.

Topics: Animals; Arachidonic Acid; Ascorbic Acid; Calcimycin; Calcium; Cells, Cultured; Dinoprostone; In Vitro Techniques; Indoles; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Spleen