caffeine has been researched along with valproic acid in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (15.79) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 19 (50.00) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Drabczyńska, A; Handzlik, J; Karcz, T; Karolak-Wojciechowska, J; Kieć-Kononowicz, K; Köse, M; Kuder, K; Müller, CE; Paskaleva, M; Schiedel, AC; Yuzlenko, O | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Markovich, VV; Molodavkin, GM; Ostrovskaia, RU | 1 |
| Baty, C; Jambou, J; Leducq, B; Richard, L | 1 |
| Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T | 1 |
| Randall, JL; Ritter, EJ; Ritter, JM; Scott, WJ | 1 |
| Cordero, JF; Oakley, GP | 1 |
| Kharlamov, AN; Raevskiĭ, KS | 1 |
| Borowicz, K; Buszewicz, G; Czuczwar, SJ; Gasior, M; Kleinrok, Z | 1 |
| David, J; Joseph, T; Kulkarni, C; Vaz, J | 1 |
| Wammanda, RD | 1 |
| Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K | 1 |
| Espinoza, JL; Kondo, Y; Lu, X; Nakao, S; Ohata, K; Qi, Z | 1 |
| Bekersky, I; Blum, RA; Tolbert, D; Walzer, M | 1 |
| Jeanray, N; Martial, JA; Muller, M; Piot, A; Pruvot, B; Quiroz, Y; Voncken, A | 1 |
| Jacob, KS; Jacob, M; Kuruvilla, A; Poonkuzhali, B; Rajkumar, AP | 1 |
| Hayashi, K; Hoffman, RM; Igarashi, K; Kimura, H; Miwa, S; Takeuchi, A; Tsuchiya, H; Yamamoto, N | 1 |
| Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Miwa, S; Murakami, T; Tsuchiya, H; Yamamoto, N | 1 |
| Dry, SM; Eilber, FC; Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Li, Y; Miwa, S; Murakami, T; Nelson, SD; Singh, AS; Tsuchiya, H; Yamamoto, N | 1 |
| Matuura, T; Mizoguchi, N; Nawaji, T; Ono, M; Seki, M; Teraoka, H | 1 |
| Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB | 1 |
4 review(s) available for caffeine and valproic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; Epidemiologic Methods; Female; Humans; Hydantoins; Immunosuppressive Agents; Lithium; Lithium Carbonate; Phenothiazines; Pregnancy; Pyridoxine; Registries; Risk; Rubella Vaccine; Solvents; Spermatocidal Agents; Trimethadione; Valproic Acid | 1983 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Humans; Lamotrigine; Mice; Nipecotic Acids; Phenobarbital; Phenytoin; Seizures; Tiagabine; Triazines; Valproic Acid | 2007 |
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Phenothiazines; Sumatriptan; Valproic Acid | 2022 |
2 trial(s) available for caffeine and valproic acid
| Article | Year |
|---|---|
Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers.
Topics: Anticonvulsants; Caffeine; Carbamazepine; Cross-Over Studies; Drug Interactions; Epilepsy; Humans; Male; Valproic Acid | 1998 |
Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Clinical Trials, Phase I as Topic; Clobazam; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Isoenzymes; Lamotrigine; Male; Midazolam; Middle Aged; Models, Statistical; Pharmacokinetics; Prospective Studies; Tolbutamide; Triazines; Valproic Acid; Young Adult | 2012 |
32 other study(ies) available for caffeine and valproic acid
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Cyclization; Humans; Hydrogen Bonding; Models, Molecular; Purines; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
[The effect of substnaces altering gamma-aminobutyric acid metabolism on the recovery cycle of the interzonal response of the cat motor cortex].
Topics: Aminobutyrates; Animals; Arecoline; Bemegride; Benactyzine; Bicuculline; Caffeine; Cats; Drug Interactions; Electrophysiology; gamma-Aminobutyric Acid; Motor Cortex; Receptors, Drug; Semicarbazides; Somatosensory Cortex; Sulfhydryl Compounds; Valproic Acid | 1975 |
[Plasma determination of 7 common drugs by high performance liquid chromatography].
Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid | 1989 |
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Hydrocortisone; Male; Middle Aged; Phenytoin; Valproic Acid | 1989 |
Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Caproates; Diethylhexyl Phthalate; Drug Synergism; Female; Hexanols; Maternal-Fetal Exchange; Phthalic Acids; Pregnancy; Rats; Rats, Inbred Strains; Valproic Acid | 1987 |
[Tranquilizing effect of n-dipropylacetate and other GABA-ergic substances in conflict situations].
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Caffeine; Conflict, Psychological; Male; Models, Psychological; Pantothenic Acid; Pentylenetetrazole; Piracetam; Pyrrolidinones; Rats; Tranquilizing Agents; Valproic Acid | 1980 |
Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
Topics: Animals; Anticonvulsants; Caffeine; Electroshock; Male; Mice; Phenobarbital; Seizures; Valproic Acid | 1996 |
Hyperactivity and inattention--a successful response to table coffee.
Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; Child, Preschool; Coffee; Humans; Male; Seizures; Treatment Outcome; Valproic Acid | 2007 |
Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis.
Topics: Caffeine; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Synergism; Gene Expression Regulation, Leukemic; GPI-Linked Proteins; Humans; Hydroxyurea; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural; Leukemia, Myeloid; Up-Regulation; Valproic Acid | 2010 |
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish | 2012 |
Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia.
Topics: Administration, Oral; Adult; Anticonvulsants; Antipsychotic Agents; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chi-Square Distribution; Chromatography, High Pressure Liquid; Clozapine; Cross-Sectional Studies; Drug Interactions; Drug Monitoring; Drug Resistance; Female; Food-Drug Interactions; Humans; Least-Squares Analysis; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Psychiatric Status Rating Scales; Risk Factors; Schizophrenia; Schizophrenic Psychology; Spectrophotometry, Ultraviolet; Treatment Failure; Valproic Acid | 2013 |
Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Caspase 3; Caspase 7; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Histone Deacetylase Inhibitors; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Osteosarcoma; Tibia; Valproic Acid | 2016 |
Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Osteosarcoma; Valproic Acid | 2017 |
Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines.
Topics: Apoptosis; Caffeine; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Osteosarcoma; Primary Cell Culture; Rhabdomyosarcoma; Valproic Acid | 2017 |
Comparing time-series of chemical concentrations in zebrafish (Danio rerio) embryos/larvae exposed to teratogens with different hydrophobicity; caffeine, sodium valproate, and diethylstilbestrol.
Topics: Animals; Caffeine; Diethylstilbestrol; Fertilization; Hydrophobic and Hydrophilic Interactions; Teratogens; Time Factors; Valproic Acid; Zebrafish | 2018 |