caffeine and uric acid

caffeine has been researched along with uric acid in 153 studies

Research

Studies (153)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (31.37)	18.7374
1990's	26 (16.99)	18.2507
2000's	34 (22.22)	29.6817
2010's	30 (19.61)	24.3611
2020's	15 (9.80)	2.80

Authors

Authors	Studies
Carty, MD; Culp, J; Danley, DE; Day, YS; Ekstrom, JL; Fletterick, RJ; Gibbs, EM; Hoover, DJ; Myszka, DG; Pauly, TA; Rath, VL; Soeller, WC; Treadway, JL	1
Bearne, SL; Lunn, FA; Roy, AC	1
Fernández, JR; Firestein, BL; Sweet, ES; Welsh, WJ	1
Bearne, SL; Steeves, CH	1
Lowitt, S; Polson, JB; Szentivanyi, A; Williams, JF	1
Kihlman, BA	1
Aldridge, A; Aranda, JV; Neims, AH	1
Shoyab, M	1
Kihlman, BA; Sturelid, S	1
Turner, T; Vasiliades, J	1
Woolfolk, CA	1
Lohmann, W; Sapper, H; Schimmack, W	1
Lohmann, W; Schimmack, W	1
Andersson, HC; Kihlman, BA	1
Dean, PM; Edwardson, JM	1
Fuhr, U; Roots, I; Rost, KL; Staib, AH	1
Kalow, W; Tang, BK	1
Iriah, J; Kadar, D; Kalow, W; Qian, L; Tang, BK; Yip, J	1
Benchekroun, Y; Brazier, JL; Desage, M; Ribon, B	1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW	1
Barrera, CM; Dohanich, GP; Dunlap, WP; Hunter, RE	1
Hafkenscheid, JC; Hekster, YA; Nouws, JF; Vree, JB; Vree, TB	1
Boda, D; Németh, I	1
Alary, J; Grosset, C; Vergnes, MF	1
Chakraborty, J; Marks, V; Morgan, MY; Scott, NR; Stambuk, D	1
Campbell, ME; Kalow, W; Spielberg, SP	1
Campbell, ME; Grant, DM; Kalow, W; Tang, BK	1
Chakraborty, J; Marks, V; Scott, NR	1
Geoffroy, S; Gilbert, SG; Klassen, RD; Rice, DC; So, Y; Stavric, B	1
Matsuzaki, F; Raben, MS	1
Phelps, P; Tse, RL; Urban, D	1
Glazigna, L; Maina, G; Rumney, G	1
Jenne, JW; Nagasawa, HT; Thompson, RD	1
Heyden, S	2
Brunk, SF; Ferguson, RK; Leaverton, PE; Nordschow, CD; Toubes, DB; Wilson, WR	1
Escher, M; Heyden, S	1
Cornish, HH; Khanna, KL; Rao, GS	3
Lumb, JR; Shankel, DM; Sideropoulos, AS	1
Essman, WB	1
Burg, AW; Stein, ME	1
Burg, AW; Werner, E	1
Lillie, RD; Pizzolato, P	1
Allam, AM; Elzainy, TA	1
Shefter, E	1
Berlin, RD; Hawkins, RA	1
Beaulieu, C; Enesco, HE; Solyom, L	1
Kihlman, BA; Odmark, G	1
Gehl, A; Rink, M	1
Berdel, D; Heimann, G	1
Ferrero, JL; Neims, AH	1
Kela, U; Trivedi, CP; Vijayvargiya, R	1
Riegelman, S; Tang-Liu, DD	1
Bonati, M; Garattini, S; Latini, R; Marzi, E	1
Hoyo-Vadillo, C; López-Munoz, FJ; Pérez-Urizar, J	1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M	1
Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE	1
Roots, I; Rost, KL	1
Andersson, T; Birkett, DJ; McManus, ME; Miners, JO; Tassaneeyakul, W; Tukey, RH; Veronese, ME	1
Bartsch, H; Bernucci, I; Caporaso, NE; Kadlubar, FF; Landi, MT; Malaveille, C; Shields, P; Skipper, P; Tannenbaum, S; Vineis, P; Zocchetti, C	1
Benchekroun, Y; Brazier, JL; Dautraix, S; Désage, M	1
Lunte, CE; Zhao, Y	1
Birkett, DJ; Day, RO; Lillywhite, KJ; Miners, JO; Valente, L	1
Castillo, EF; Chaves, F; Herrera, JE; Medina, R; Reyes, G; Tinajero, J; Valdes, B	1
Fuchs, P; Haefeli, WE; Ledermann, HR; Wenk, M	1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B	1
Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K	1
Madhavi, YS; Madyastha, KM; Sridhar, GR; Vadiraja, BB	1
Boda, D; Boda, M; Németh, I	1
Hamada, H; Honjo, S; Kiyohara, C; Koga, H; Kono, S; Nakagawa, K; Nishikawa, H; Nishiwaki, M; Ogawa, S; Sakurai, Y; Todoroki, I	1
Decker, H; Grieshaber, MK; Hellmann, N; Menze, MA	2
Ercan-Fang, NG; Gannon, MC; Nuttall, FQ	1
Decker, H; Grieshaber, M; Hellmann, N; Menze, M	1
Georgia, KA; Papadoyannis, IN; Samanidou, VF	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT	1
Crews, HM; Olivier, L; Wilson, LA	1
Cameron, IL; Lyles, MB	1
Hammons, G; Kadlubar, FF; Lang, NP; Nowell, S; Sweeney, C	1
Ashihara, H; Crozier, A; Kato, M; Ye, CX; Zheng, XQ	1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y	1
Fujieda, M; Ishizaki, T; Kamataki, T; Nakagawa, K; Saruwatari, J; Shindo, J; Tajiri, T; Yamazaki, H	1
Bjelakovic, G; Nikolic, J; Stojanovic, I	1
Azam, S; Hadi, N; Hadi, SM; Khan, NU	1
CHRISTMAN, AA; WEINFELD, H	1
JEFFREY, JJ; SCHANKER, LS; TOCCO, DJ	1
SIMON, MI; VANVUNAKIS, H	1
CAILLET, J; CLAVERIE, P; PULLMAN, B	1
Borlak, J; Cascorbi, I; Erb, K; Fuhr, U; Hermann, R; Illauer, M; Jetter, A; Kinzig-Schippers, M; Smith, G; Sörgel, F; Wolf, H	1
Mazzafera, P	1
Baranowska, I; Baranowski, J; Zydroń, M	1
Jonderko, G; Marcisz, C; Olak, Z; Olak-Białoń, B; Orzeł, A; Szymszal, J	1
Miyazaki, K; Mochizuki, T; Sugawara, M; Takekuma, Y	1
Bending, MR; Davies, PM; Fairbanks, LD; Safranow, K; Simmonds, HA	1
Li, J; Peng, XQ; Xu, JP; Zhang, J	1
Brüning, T; John, A; Rihs, HP; Scherenberg, M; Seidel, A	1
Brøsen, K; Damkier, P; Grandjean, P; Halling, J; Nielsen, F; Petersen, MS; Weihe, P	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Bonita, JS; Mandarano, M; Shuta, D; Vinson, J	1
Choi, HK; Curhan, G	1
Fanlo, A; Ferrandez-Longás, A; Labarta, JI; Mayayo, E; Mayayo-Sinués, E; Sinués, B; Vicente, J	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Yu, CL	1
Arenaz, I; Carcas, C; Cebollada, A; Fanlo, A; Mayayo, E; Sinues, B; Vicente, J	1
Brown, CM; Dulloo, AG; Montani, JP	1
Fuhr, U; Jetter, A; Kinzig, M; Rodamer, M; Sörgel, F; Tomalik-Scharte, D	1
Grieshaber, MK; Menze, MA; Pott, A	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Ashida, H; Hashimoto, T; Kanazawa, K; Nakabayashi, H; Nishiumi, S	1
Chohnabayashi, N; Kizu, J; Nasu, H; Nishimura, N; Uchiyama, N; Watanabe, Y	1
Carta, AR; Kachroo, A; Morelli, M; Schwarzschild, MA	1
Aklillu, E; Carrillo, JA; Djordjevic, N; Fukasawa, T; Gervasini, G; Jankovic, S; Suda, A; Ueda, N	1
Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Wang, F; Watabe, M	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Karlsson, S; Roh, HK; Ueda, N	1
Das, S; Gakhar, L; Louie, TM; Mohanty, SK; Subramanian, M; Yu, CL	1
Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Shimizu, M; Yamazaki, H	1
John, SA; Raj, MA	1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB	1
Bae, J; Choi, BY; Chun, BY; Kim, MK; Kim, SK; Lee, YH; Park, PS; Shin, DH; Shin, MH	1
Gong, P; He, RR; Hu, HH; Kurihara, H; Li, SB; Li, YF; Mao, ZF; Ouyang, SH; Tsoi, B; Wu, YP	1
Costa-Bauza, A; Grases, F; Rodriguez, A	1
Curhan, GC; Ferraro, PM; Gambaro, G; Taylor, EN	1
Ergul, B; Zhao, EH; Zhao, W	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP	1
Adehin, A; Bolaji, OO	1
Bloomer, RJ; Joyner, KJ; Kuhman, DJ	1
Cao, H; Chang, YQ; He, RR; Kurihara, H; Li, WX; Li, YF; Ouyang, SH; Tian, HY; Wang, TM	1
Kishimoto, I; Kobayashi, K; Murayama, N; Shimizu, M; Yamazaki, H	1
Delamarre, A; Meissner, WG	1
Bai, X; He, J; Li, T; Qiao, H; Xu, J; Ye, X; Zhang, J; Zhang, W	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Makonnen, E	1
Dong, ZB; Liang, YR; Lu, J; Ma, YX; Wu, HS; Wu, XH; Ye, JH; Zheng, XQ	1
Calvó, P; Costa-Bauza, A; Grases, F; Prieto, RM; Rodriguez, A	1
Hopkins, A; Marshall, JC; Miners, JO; Rowland, A; Sorich, MJ; van Dyk, M; Wood, LS	1
Cesareo, KR; Mason, JR; Morrissey, MC; Ormsbee, MJ; Saracino, PG	1
Abe, I; Cao, ZQ; Ding, K; Duan, WJ; Gong, HB; He, RR; Hu, D; Kurihara, H; Li, YF; Lu, X; Ouyang, SH; Sun, WY; Tan, L; Wang, Y; Xie, C; Xie, G; Zhang, YH; Zhang, ZM	1
Ascherio, A; Bakshi, R; Gomperts, SN; Growdon, JH; Hayes, MT; Hung, AY; Hyman, BT; Macklin, EA; Scherzer, CR; Schwarzschild, MA; Wills, AM	1
Chen, L; Jiang, CK; Jin, JQ; Yao, MZ	1
Bloomer, RJ; Butawan, M; Mondal, G; Wang, YH; Yates, CR	1
Gowthaman, NSK; John, SA; Sinduja, B	1
Kertys, M; Kmeťová, K; Maráková, K; Mokrý, J; Pršo, K; Žideková, N	1
Chen, X; Gu, M; Shao, S; Wang, P; Yang, R; Ye, N; Zhao, F	1
Geng, Q; Jiang, C; Liu, A; Liu, Q; Ma, H; Yin, H; Zhou, H	1
Arent, SM; Bello, ML; Cardaci, TD; Chandler, AJ; Cintineo, HP; McFadden, BA	1
Anitta, S; Meenakshi, S; Sekar, C; Sudhan, N	1
Cerqueira, HSC; Corrêa Junior, M; Filho, HT; Martinelli Junior, CE	1
Aoyama, K; Bhadhprasit, W; Kinoshita, C; Matsumura, N; Nakaki, T	1
Dai, Q; Fang, J; Li, B; Liu, H; Xie, R; Xu, Y	1
Fatibello-Filho, O; Feitosa, MHA; Moraes, FC; Santos, AM; Sotomayor, MDPT; Wong, A	1
Aoyama, K; Matsumura, N	1

Reviews

10 review(s) available for caffeine and uric acid

Article	Year
[Coffee-drinking from the medical point of view]. Schweizerische medizinische Wochenschrift, 1973, Volume: 103, Issue:43 Topics: Adult; Blood Pressure; Caffeine; Coffee; Diabetes Mellitus; Feeding Behavior; Female; Gout; Health Surveys; Humans; Hypertension; Male; Myocardial Infarction; Uric Acid	1973
Drug effects and learning and memory processes. Advances in pharmacology and chemotherapy, 1971, Volume: 9 Topics: Amines; Amphetamine; Animals; Caffeine; Catecholamines; Hypnotics and Sedatives; Indoles; Learning; Macromolecular Substances; Magnesium; Malonates; Memory; Nicotine; Nitriles; Parasympathetic Nervous System; Pemoline; Pentylenetetrazole; Picrotoxin; RNA; Strychnine; Tranquilizing Agents; Uric Acid	1971
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry. The Journal of experimental biology, 2001, Volume: 204, Issue:Pt 5 Topics: Allosteric Regulation; Animals; Caffeine; Calorimetry; Crustacea; Hemocyanins; Nephropidae; Uric Acid	2001
Catabolism of caffeine in plants and microorganisms. Frontiers in bioscience : a journal and virtual library, 2004, May-01, Volume: 9 Topics: Bacteria; Caffeine; Fungi; Molecular Sequence Data; Plants; Uric Acid; Yeasts	2004
Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies. Pharmacological research, 2007, Volume: 55, Issue:3 Topics: Animals; Antioxidants; Blood Pressure; Caffeine; Cardiovascular Diseases; Clinical Trials as Topic; Coffee; Diterpenes; Flavonoids; Humans; Lipids; Lipoproteins, LDL; Phenols; Polyphenols; Risk Factors; Uric Acid	2007
Sugary drinks in the pathogenesis of obesity and cardiovascular diseases. International journal of obesity (2005), 2008, Volume: 32 Suppl 6 Topics: Adiposity; Animals; Beverages; Caffeine; Cardiovascular Diseases; Dietary Sucrose; Dogs; Fructose; Humans; Insulin Resistance; Obesity; Rats; Sweetening Agents; Uric Acid	2008
Pathophysiological roles for purines: adenosine, caffeine and urate. Progress in brain research, 2010, Volume: 183 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Caffeine; Dopamine; Humans; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Uric Acid	2010
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21 Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobromine; Theophylline; Uric Acid	2015
Epidemiology, environmental risk factors and genetics of Parkinson's disease. Presse medicale (Paris, France : 1983), 2017, Volume: 46, Issue:2 Pt 1 Topics: Age Distribution; Age of Onset; alpha-Synuclein; Caffeine; Causality; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Mutation; Oxidative Stress; Parkinson Disease; Pesticides; Polymorphism, Single Nucleotide; Prevalence; Risk Factors; Sex Distribution; Smoking; Uric Acid	2017
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives. International journal of molecular sciences, 2023, Aug-22, Volume: 24, Issue:17 Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid	2023

Trials

9 trial(s) available for caffeine and uric acid

Article	Year
A teaching format in clinical pharmacology. Comparison of two xanthines and a placebo. The Journal of clinical pharmacology and new drugs, 1973, Volume: 13, Issue:4 Topics: Adult; Blood Glucose; Blood Pressure; Caffeine; Education, Medical, Undergraduate; Humans; Pharmacology; Placebos; Pulse; Respiration; Stimulation, Chemical; Teaching; Theobromine; Uric Acid; Xanthines	1973
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children]. Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16 Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines	1984
Urinary biomarkers for assessing dietary exposure to caffeine. Food additives and contaminants, 2001, Volume: 18, Issue:12 Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines	2001
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers. Drug metabolism letters, 2012, Jun-01, Volume: 6, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult	2012
Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients, 2015, Nov-19, Volume: 7, Issue:11 Topics: Affect; Appetite; Blood Pressure; Caffeine; Camellia; Cognition; Cross-Over Studies; Diet Records; Dietary Supplements; Double-Blind Method; Female; Heart Rate; Humans; Male; Motor Activity; Plant Extracts; Plant Leaves; Reaction Time; Uric Acid; Young Adult	2015
Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. European journal of clinical pharmacology, 2019, Volume: 75, Issue:9 Topics: Adult; Biomarkers; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Diet; Genotype; Humans; Male; Midazolam; Phenotype; Racial Groups; Rifampin; Uric Acid; Young Adult	2019
The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men. Journal of the International Society of Sports Nutrition, 2019, Oct-28, Volume: 16, Issue:1 Topics: Adult; Caffeine; Cross-Over Studies; Double-Blind Method; Humans; Male; Muscle Strength; Muscle, Skeletal; Performance-Enhancing Substances; Physical Endurance; Resistance Training; Uric Acid; Young Adult	2019
Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 2022, Volume: 19, Issue:1 Topics: Alkaloids; Athletic Performance; Caffeine; Double-Blind Method; Heart Rate; Humans; Polyesters; Purines; Uric Acid	2022
Effects of Theacrine as a Pre-Workout Supplement. International journal of environmental research and public health, 2022, 10-28, Volume: 19, Issue:21 Topics: Caffeine; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Humans; Male; Uric Acid	2022

Other Studies

134 other study(ies) available for caffeine and uric acid

Article	Year
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chemistry & biology, 2002, Volume: 9, Issue:8 Topics: Allosteric Site; Binding Sites; Crystallography, X-Ray; Diabetes Mellitus; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glycogen Phosphorylase; Humans; Hydrogen Bonding; Ligands; Liver; Molecular Structure; Purines; Structure-Activity Relationship; Water	2002
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines	2010
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine. Bioorganic & medicinal chemistry, 2010, Sep-15, Volume: 18, Issue:18 Topics: Binding Sites; Cognition Disorders; Energy Metabolism; Guanine; Guanine Deaminase; Humans; Kinetics; Ligands; Liver Diseases; Microtubules; Molecular Dynamics Simulation; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship	2010
Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Antiprotozoal Agents; Biocatalysis; Carbon-Nitrogen Ligases; Dose-Response Relationship, Drug; Enzyme Activation; Purines; Recombinant Proteins; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosomiasis, African	2011
Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine. Biochemical pharmacology, 1978, Volume: 27, Issue:11 Topics: Animals; Caffeine; Dogs; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Phosphoric Diester Hydrolases; Theophylline; Trachea; Uric Acid; Xanthines	1978
1,3,7,9-tetramethyluric acid--a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants. Mutation research, 1977, Volume: 39, Issue:3-4 Topics: Adenosine Triphosphate; Animals; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Coffee; Cricetinae; DNA; Escherichia coli; In Vitro Techniques; Mutation; Phosphorylases; Plants; RNA; Solubility; Uric Acid	1977
Caffeine metabolism in the newborn. Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:4 Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Time Factors; Uric Acid; Xanthines	1979
The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine. Cancer letters, 1979, Volume: 8, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Caffeine; DNA; Hypoxanthines; In Vitro Techniques; Mice; Microsomes, Liver; Stimulation, Chemical; Theobromine; Theophylline; Uric Acid	1979
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations. Hereditas, 1975, Volume: 79, Issue:1 Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug Synergism; Methylation; Mutation; Plants; Purines; Theobromine; Theophylline; Thiotepa; Uric Acid	1975
A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates. Clinica chimica acta; international journal of clinical chemistry, 1976, Jun-15, Volume: 69, Issue:3 Topics: Barbiturates; Caffeine; Humans; Hypoxanthines; Spectrophotometry, Ultraviolet; Theophylline; Uric Acid; Xanthines	1976
Metabolism of N-methylpurines by a Pseudomonas putida strain isolated by enrichment on caffeine as the sole source of carbon and nitrogen. Journal of bacteriology, 1975, Volume: 123, Issue:3 Topics: Alcohol Oxidoreductases; Biological Transport, Active; Caffeine; Cell Membrane Permeability; Enzyme Induction; Ferricyanides; Formaldehyde; Formates; Kinetics; Methanol; Oxygen Consumption; Pseudomonas; Subcellular Fractions; Uric Acid; Xanthine Dehydrogenase; Xanthines	1975
Stacking interactions of nucleobases: NMR-investigations. II. Self-association of purine-and pyrimidine-derivatives. Biophysics of structure and mechanism, 1975, Dec-19, Volume: 1, Issue:4 Topics: Adenine; Adenosine; Caffeine; Chemical Phenomena; Chemistry; Cytosine; Deuterium; Hypoxanthines; Magnetic Resonance Spectroscopy; Polymers; Purines; Pyrimidines; Thermodynamics; Uracil; Uric Acid; Water	1975
Association of sexual hormones with nucleobases in water: NMR-investigations. Biophysics of structure and mechanism, 1975, Dec-19, Volume: 1, Issue:4 Topics: Adenine; Adenosine; Caffeine; Chemical Phenomena; Chemistry; Cytosine; Deuterium; Estradiol; Hypoxanthines; Magnetic Resonance Spectroscopy; Purines; Pyrimidines; Testosterone; Thermodynamics; Uracil; Uric Acid; Water	1975
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba. Mutation research, 1992, Volume: 269, Issue:2 Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid	1992
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure. Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11 Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Inositol; Male; Mice; Phenytoin; Structure-Activity Relationship; Theophylline; Uric Acid	1992
Theophylline metabolism affected by mexiletine. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines	1992
Caffeine as a metabolic probe: exploration of the enzyme-inducing effect of cigarette smoking. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:1 Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Liver; Nicotiana; Oxidoreductases; Plants, Toxic; Smoking; Uric Acid; Xanthines	1991
Caffeine as a metabolic probe: validation of its use for acetylator phenotyping. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:6 Topics: Acetylation; Acetyltransferases; Adult; Caffeine; Humans; Phenotype; Polymorphism, Genetic; Sulfamethazine; Time Factors; Uracil; Uric Acid; Xanthines	1991
Gas chromatographic-mass spectrometric quantitation of tri-, di- and monomethylxanthines and uric acids from hepatocyte incubation media. Journal of chromatography, 1990, Nov-16, Volume: 532, Issue:2 Topics: Animals; Caffeine; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Regression Analysis; Uric Acid; Xanthines	1990
Human N-acetylation genotype determination with urinary caffeine metabolites. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines	1990
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain. Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4 Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inbred Strains; Receptors, Purinergic; Time Factors; Uric Acid	1990
Excretion and metabolism of a series of xanthines by the turtle Pseudemys scripta elegans. The veterinary quarterly, 1989, Volume: 11, Issue:1 Topics: Animals; Caffeine; Theobromine; Theophylline; Turtles; Uric Acid; Xanthine; Xanthines	1989
Measurement of urinary caffeine metabolites reflecting the "in vivo" xanthine oxidase activity in premature infants with RDS and in hypoxic states of children. Biomedica biochimica acta, 1989, Volume: 48, Issue:2-3 Topics: Biomarkers; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Respiratory Distress Syndrome, Newborn; Uric Acid; Xanthine Oxidase	1989
[HPLC study of potential metabolites of caffeine. Comparison of various techniques]. Journal of chromatography, 1988, Nov-25, Volume: 455 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Liver; Uric Acid; Xanthines	1988
Caffeine clearance and biotransformation in patients with chronic liver disease. Clinical science (London, England : 1979), 1988, Volume: 74, Issue:4 Topics: Adult; Aged; Biotransformation; Caffeine; Chronic Disease; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Uric Acid; Xanthines	1988
A urinary metabolite ratio that reflects systemic caffeine clearance. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:2 Topics: Adult; Age Factors; Asian People; Caffeine; Child; Child, Preschool; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Smoking; Time Factors; Uracil; Uric Acid; White People; Xanthines	1987
Effect of allopurinol on caffeine disposition in man. British journal of clinical pharmacology, 1986, Volume: 21, Issue:4 Topics: Adult; Allopurinol; Biotransformation; Caffeine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Kidney; Kinetics; Male; Uric Acid; Xanthine Oxidase; Xanthines	1986
Urinary metabolites of caffeine in pregnant women. British journal of clinical pharmacology, 1986, Volume: 22, Issue:4 Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines	1986
Elimination of chronically consumed caffeine in the pregnant monkey (Macaca fascicularis). The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Drinking; Eating; Female; Macaca fascicularis; Pregnancy; Pregnancy, Animal; Theophylline; Uric Acid	1986
Effect of purines on epinephrine-induced lipolysis in adipose tissue. The Journal of biological chemistry, 1966, Oct-25, Volume: 241, Issue:20 Topics: Adenine; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Enzymes; Epinephrine; Fatty Acids; Guanine; Hypoxanthines; In Vitro Techniques; Lipid Metabolism; Purines; Rats; Uric Acid; Xanthines	1966
Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP. The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2 Topics: Adenine; Caffeine; Cyclic AMP; Epinephrine; Guanine; Guanosine; Humans; Hypoxanthines; Imidazoles; Leukocytes; Movement; Purines; Pyrimidines; Reserpine; Structure-Activity Relationship; Theophylline; Thymine; Uracil; Uric Acid; Xanthines	1972
Role of L-ascorbic acid in the reversal of the monoamine oxidase inhibition by caffeine. The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:4 Topics: Animals; Ascorbic Acid; Caffeine; Ephedrine; Haplorhini; In Vitro Techniques; Iproniazid; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Rats; Serotonin; Tyramine; Uric Acid	1971
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography. The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:4 Topics: Administration, Oral; Aminophylline; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Humans; Hypoxanthines; Methylation; Pressure; Theophylline; Uric Acid; Xanthines	1974
[Effects of coffee during good health and in disease from the medical standpoint]. Minerva medica, 1974, Jan-17, Volume: 65, Issue:3 Topics: Acute Disease; Aged; Blood Pressure; Caffeine; Cerebrovascular Disorders; Coffee; Diabetes Mellitus; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Gout; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Smoking; Stimulation, Chemical; Uric Acid; Urinary Bladder Neoplasms	1974
Metabolism of caffeine- 3 H in the rat. Toxicology and applied pharmacology, 1972, Volume: 23, Issue:4 Topics: Animals; Caffeine; Chromatography, Thin Layer; Male; Mass Spectrometry; Rats; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Tritium; Uric Acid; Xanthines	1972
Mass spectrometric identification of methylxanthines and methyluric acids, the possible metabolites of caffeine. Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:11 Topics: Caffeine; Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Theobromine; Theophylline; Uric Acid; Xanthines	1972
Identification of two new metabolites of caffeine in the rat urine. Experientia, 1973, Aug-15, Volume: 29, Issue:8 Topics: Allantoin; Animals; Biotransformation; Caffeine; Chromatography, Thin Layer; Hydantoins; Mass Spectrometry; Rats; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Uric Acid	1973
The influence of analogs of xanthine on the mutagenic effect of ultraviolet light. Molecular & general genetics : MGG, 1968, Volume: 102, Issue:2 Topics: Caffeine; Drug Synergism; Escherichia coli; Mutation; Purines; Theophylline; Ultraviolet Rays; Uric Acid; Xanthines	1968
Urinary excretion of caffeine and its metabolites in the mouse. Biochemical pharmacology, 1972, Apr-01, Volume: 21, Issue:7 Topics: Animals; Caffeine; Carbon Dioxide; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Feces; Humans; Kinetics; Male; Methylation; Mice; Mice, Inbred Strains; Tritium; Uric Acid; Water; Xanthines	1972
Tissue distribution of caffeine and its metabolites in the mouse. Biochemical pharmacology, 1972, Apr-01, Volume: 21, Issue:7 Topics: Animals; Brain; Caffeine; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Erythrocytes; Half-Life; Kinetics; Liver; Lung; Male; Methylation; Mice; Mice, Inbred Strains; Muscles; Myocardium; Nucleotides; Spleen; Testis; Tritium; Uric Acid; Xanthines	1972
Histochemical azo coupling reactions of the pigments of obstructive icterus and of hematoidin. II. Effect of blockade, bleaching and extraction procedures on the pigments and their azo derivatives. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1970, Volume: 18, Issue:2 Topics: Acetates; Azo Compounds; Benzoates; Bile Pigments; Caffeine; Cholestasis; Chromates; Histocytochemistry; Hydrogen-Ion Concentration; Iodine; Sulfites; Uric Acid	1970
Purine catabolism in Fusarium moniliforme. Journal of general microbiology, 1970, Volume: 63, Issue:2 Topics: Allantoin; Amidohydrolases; Ammonia; Caffeine; Cell-Free System; Culture Media; Fusarium; Glyoxylates; Hydantoins; Hypoxanthines; Purines; Theobromine; Time Factors; Urate Oxidase; Urea; Urease; Ureohydrolases; Uric Acid; Xanthenes	1970
[The BBC study. Applied epidemiology of ischemic heart diseases]. Archiv fur Kreislaufforschung, 1967, Volume: 53, Issue:1 Topics: Adult; Body Weight; Caffeine; Cholesterol; Coronary Disease; Epidemiologic Methods; Hematocrit; Humans; Hypercholesterolemia; Hyperglycemia; Hypertension; Male; Middle Aged; Myocardial Infarction; Nutritional Physiological Phenomena; Occupational Medicine; Physical Exertion; Smoking; Switzerland; Triglycerides; Uric Acid	1967
Structural studies on complexes. I. Postulation of polarization bonding in xanthine complexes. Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:2 Topics: Caffeine; Chemical Phenomena; Chemistry; Electrochemistry; Models, Chemical; Theophylline; Uric Acid; Xanthines	1968
Secretion of purines by the small intestine: general characteristics. The American journal of physiology, 1968, Volume: 215, Issue:4 Topics: Adenine; Allopurinol; Animals; Biological Transport; Caffeine; Carbon Isotopes; Chromatography, Paper; Cricetinae; Female; Hypoxanthines; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Methods; Nucleotides; Purines; Pyrimidines; Tritium; Uric Acid; Xanthine Oxidase	1968
The effect of RNA, uric acid and caffein on conditioning and activity in rats. Journal of psychiatric research, 1968, Volume: 6, Issue:3 Topics: Analysis of Variance; Animals; Basal Metabolism; Behavior, Animal; Caffeine; Conditioning, Classical; Conditioning, Operant; Conditioning, Psychological; Female; Oxygen Consumption; Rats; Reinforcement Schedule; RNA; Stimulation, Chemical; Uric Acid	1968
Deoxyribonucleic acid synthesis and the production of chromosomal aberrations by streptonigrin, 8-ethoxy-caffeine and 1,3,7,9-tetramethyluric acid. Mutation research, 1965, Volume: 2, Issue:6 Topics: Antibiotics, Antineoplastic; Autoradiography; Caffeine; Cell Division; Chromosomes; DNA; Phosphates; Phosphorus Isotopes; Plants; RNA; Streptonigrin; Thymidine; Tritium; Uric Acid	1965
[Thin-layer chromatographic separation of some purine derivatives, including uric acid]. Journal of chromatography, 1966, Volume: 21, Issue:1 Topics: Adenine; Caffeine; Chromatography, Thin Layer; Guanine; Hypoxanthines; Purines; Theobromine; Theophylline; Uric Acid; Xanthines	1966
Metabolism of caffeine by mouse liver microsomes: GSH or cytosol causes a shift in products from 1,3,7-trimethylurate to a substituted diaminouracil. Life sciences, 1983, Sep-19, Volume: 33, Issue:12 Topics: Animals; Biotransformation; Caffeine; Carbon Radioisotopes; Cytosol; Glutathione; Liver; Male; Mice; Mice, Inbred AKR; Microsomes, Liver; Structure-Activity Relationship; Uracil; Uric Acid; Xanthines	1983
Inhibitory effects of methylxanthines on the activity of xanthine oxidase. Life sciences, 1980, Dec-01, Volume: 27, Issue:22 Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines	1980
An automated HPLC assay for simultaneous quantitation of methylated xanthines and uric acids in urine. Journal of chromatographic science, 1982, Volume: 20, Issue:4 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Values; Uric Acid; Xanthines	1982
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man. Toxicology letters, 1981, Volume: 7, Issue:3 Topics: Adult; Animals; Biotransformation; Caffeine; Humans; Macaca fascicularis; Male; Rats; Species Specificity; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines	1981
Usefulness of the pain-induced functional impairment model to relate plasma levels of analgesics to their efficacy in rats. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:6 Topics: Analgesics; Animals; Caffeine; Drug Interactions; Female; Movement Disorders; Naproxen; Pain Measurement; Rats; Rats, Wistar; Uric Acid	1995
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes. Genetic epidemiology, 1994, Volume: 11, Issue:2 Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines	1994
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:7 Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; Hindlimb; Pain; Pain Measurement; Rats; Rats, Wistar; Uric Acid	1993
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid	1994
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochemical pharmacology, 1994, May-18, Volume: 47, Issue:10 Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Theobromine; Theophylline; Uric Acid	1994
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:9 Topics: Age Factors; Alcohol Drinking; Aminobiphenyl Compounds; Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Coffee; Cytochrome P-450 CYP1A2; DNA Adducts; Drinking; Enzyme Induction; Glutathione Transferase; Hemoglobins; Humans; Male; Meat; Middle Aged; Nicotiana; Oxidation-Reduction; Phenotype; Plants, Toxic; Polymorphism, Genetic; Risk Factors; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms	1996
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2 Topics: Animals; Caffeine; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Kidney; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Uric Acid	1997
Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2 Topics: Animals; Beverages; Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Sodium Dodecyl Sulfate; Tablets; Theobromine; Theophylline; Uric Acid	1997
1-Methylxanthine derived from caffeine as a pharmacodynamic probe of oxypurinol effect. British journal of clinical pharmacology, 1997, Volume: 43, Issue:2 Topics: Adult; Caffeine; Female; Humans; Male; Molecular Probes; Oxypurinol; Uric Acid; Xanthines	1997
On the analgesic effect of sodium diclofenac in pain-induced functional impairment in the rat. Proceedings of the Western Pharmacology Society, 1998, Volume: 41 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Male; Motor Activity; Pain; Rats; Rats, Wistar; Time Factors; Uric Acid	1998
Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. European journal of clinical pharmacology, 1999, Volume: 54, Issue:11 Topics: Allopurinol; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Humans; Male; Oxypurinol; Prospective Studies; Uric Acid; Xanthine Oxidase	1999
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines	1999
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats. Biochemical pharmacology, 1998, May-01, Volume: 55, Issue:9 Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid	1998
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium. Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2 Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase	1999
The caffeine metabolic ratio as an index of xanthine oxidase activity in clinically active and silent celiac patients. Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:5 Topics: Caffeine; Celiac Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Iron; Male; Uric Acid; Xanthine Oxidase; Xanthines	1999
Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males. The British journal of nutrition, 1999, Volume: 82, Issue:2 Topics: Alcohol Drinking; Analysis of Variance; Blood Glucose; Caffeine; Coffee; Cross-Sectional Studies; Dairy Products; Diuresis; Humans; Japan; Male; Middle Aged; Tea; Uric Acid	1999
Binding of urate and caffeine to hemocyanin of the lobster Homarus vulgaris (E.) as studied by isothermal titration calorimetry. Biochemistry, 2000, Sep-05, Volume: 39, Issue:35 Topics: Animals; Binding Sites; Buffers; Caffeine; Calorimetry; Hemocyanins; Hydrogen-Ion Concentration; Male; Nephropidae; Thermodynamics; Titrimetry; Tromethamine; Uric Acid	2000
Uric acid inhibits liver phosphorylase a activity under simulated in vivo conditions. American journal of physiology. Endocrinology and metabolism, 2001, Volume: 280, Issue:2 Topics: Adenine Nucleotides; Animals; Caffeine; Drug Combinations; Enzyme Inhibitors; Glucose; Liver; Male; Osmolar Concentration; Phosphorylase a; Rats; Rats, Sprague-Dawley; Uric Acid	2001
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin. Journal of chromatography. B, Biomedical sciences and applications, 2001, Aug-15, Volume: 759, Issue:2 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Uric Acid; Xanthines	2001
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
[HPLC determination of five caffeine metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines	1997
Caffeine and other xanthines as cytochemical blockers and removers of heterocyclic DNA intercalators from chromatin. Cell biology international, 2002, Volume: 26, Issue:2 Topics: Acridine Orange; Aminophylline; Animals; Caffeine; Cell Nucleus; Central Nervous System Stimulants; Chick Embryo; Chromatin; Chromosomes; DNA; Fluorescent Dyes; Intercalating Agents; Kinetics; Microscopy, Fluorescence; Mutagens; Phosphodiesterase Inhibitors; Protein Binding; Spectrometry, Fluorescence; Time Factors; Uric Acid; Xanthine	2002
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:4 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Colorectal Neoplasms; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Theophylline; Uric Acid	2002
Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry, 2002, Volume: 60, Issue:2 Topics: Adenosine; Alkaloids; Beverages; Caffeine; Camellia; Carbon Radioisotopes; Methylation; Molecular Structure; Plant Leaves; Staining and Labeling; Time Factors; Uric Acid	2002
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines	2002
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Arylamine N-Acetyltransferase; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Genotype; Humans; Japan; Male; Phenotype; Reference Values; Uric Acid; Xanthine Oxidase	2002
Effect of caffeine on metabolism of L-arginine in the brain. Molecular and cellular biochemistry, 2003, Volume: 244, Issue:1-2 Topics: Amine Oxidase (Copper-Containing); Animals; Arginase; Arginine; Brain; Caffeine; Central Nervous System Stimulants; Creatine; Humans; Lipid Peroxidation; Male; Malondialdehyde; Polyamines; Rats; Rats, Wistar; Urea; Uric Acid	2003
Antioxidant and prooxidant properties of caffeine, theobromine and xanthine. Medical science monitor : international medical journal of experimental and clinical research, 2003, Volume: 9, Issue:9 Topics: Animals; Antioxidants; Caffeine; Cattle; Copper; DNA; DNA Damage; Hydroxyl Radical; Oxidants; Plasmids; Theobromine; Uric Acid; Xanthine	2003
The metabolism of caffeine and theophylline. The Journal of biological chemistry, 1953, Volume: 200, Issue:1 Topics: Body Fluids; Caffeine; Humans; Theophylline; Uric Acid; Urine	1953
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE. Biochemical pharmacology, 1963, Volume: 12 Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines	1963
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES. Archives of biochemistry and biophysics, 1964, Volume: 105 Topics: Caffeine; Guanine; Guanine Nucleotides; Hydrogen-Ion Concentration; Hypoxanthines; Infrared Rays; Light; Manometry; Methylene Blue; Nucleosides; Oxidation-Reduction; Purines; Research; Theobromine; Theophylline; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uric Acid; Xanthines	1964
INTERMOLECULAR FORCES IN ASSOCIATION OF PURINES WITH POLYBENZENOID HYDROCARBONS. Science (New York, N.Y.), 1965, Mar-12, Volume: 147, Issue:3663 Topics: Adenine; Benzopyrenes; Caffeine; Chemical Phenomena; Chemistry; Cytosine; Guanine; Hypoxanthines; London; Purines; Pyrimidines; Research; Thymine; Uracil; Uric Acid; Xanthines	1965
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. European journal of clinical pharmacology, 2004, Volume: 60, Issue:1 Topics: Acetylation; Administration, Oral; Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Diet; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Spectrometry, Mass, Electrospray Ionization; Time Factors; Uracil; Uric Acid; Xanthines	2004
Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples. Journal of separation science, 2004, Volume: 27, Issue:14 Topics: Caffeine; Calibration; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Theobromine; Uric Acid; Urine; Xanthines	2004
[Does coffee drinking influence serum uric acid concentration?]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57 Suppl 1 Topics: Adult; Aged; Caffeine; Chi-Square Distribution; Coffee; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Poland; Sex Factors; Uric Acid	2004
Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites. Biochimica et biophysica acta, 2005, Aug-15, Volume: 1714, Issue:2 Topics: Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Cricetulus; Humans; Molecular Structure; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Theobromine; Theophylline; Uric Acid; Xanthines	2005
Allosteric models for multimeric proteins: oxygen-linked effector binding in hemocyanin. Biochemistry, 2005, Aug-02, Volume: 44, Issue:30 Topics: Allosteric Regulation; Animals; Binding Sites; Caffeine; Calorimetry; Hemocyanins; Hypoxia; Models, Chemical; Nephropidae; Oxygen; Protein Binding; Protein Conformation; Uric Acid	2005
An unusual patient with kidney stones composed of 1-methyluric acid. Urological research, 2006, Volume: 34, Issue:1 Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Humans; Kidney Calculi; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Uric Acid	2006
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines	2006
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 376, Issue:1-2 Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Genotype; Humans; Male; Middle Aged; Phenotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Uracil; Uric Acid; White People; Xanthines	2007
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. European journal of clinical pharmacology, 2006, Volume: 62, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Biometry; Caffeine; Cohort Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Female; Genotype; Humans; Male; Methylation; Middle Aged; Polychlorinated Biphenyls; Sex Factors; Smoking; Uracil; Uric Acid; Xanthines	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Arthritis and rheumatism, 2007, Jun-15, Volume: 57, Issue:5 Topics: Caffeine; Central Nervous System Stimulants; Coffee; Diet Surveys; Drinking Behavior; Female; Humans; Hyperuricemia; Male; Middle Aged; Tea; United States; Uric Acid	2007
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children. Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:1 Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Genotype; Growth Disorders; Human Growth Hormone; Humans; Injections, Subcutaneous; Male; Mixed Function Oxygenases; Recombinant Proteins; Theophylline; Uric Acid	2008
A novel caffeine dehydrogenase in Pseudomonas sp. strain CBB1 oxidizes caffeine to trimethyluric acid. Journal of bacteriology, 2008, Volume: 190, Issue:2 Topics: Bacterial Proteins; Caffeine; Oxidoreductases; Pseudomonas; Substrate Specificity; Theobromine; Ubiquinone; Uric Acid; Xanthine	2008
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives. Human & experimental toxicology, 2008, Volume: 27, Issue:5 Topics: Adolescent; Adult; Age Factors; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Phenotype; Risk Factors; Sex Factors; Smoking; Spain; Theophylline; Uric Acid	2008
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? European journal of clinical pharmacology, 2009, Volume: 65, Issue:4 Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Humans; Male; Phenotype; Time Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2009
Thermodynamics of effector binding to hemocyanin: influence of temperature. Archives of biochemistry and biophysics, 2009, Mar-01, Volume: 483, Issue:1 Topics: Allosteric Regulation; Animals; Binding Sites; Caffeine; Hemocyanins; Hemolymph; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Ligands; Models, Biological; Nephropidae; Oxygen; Protein Binding; Temperature; Thermodynamics; Uric Acid	2009
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. BioFactors (Oxford, England), 2008, Volume: 34, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines	2008
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation. Biomedical chromatography : BMC, 2011, Volume: 25, Issue:4 Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theophylline; Uric Acid	2011
N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population. Journal of clinical pharmacology, 2011, Volume: 51, Issue:7 Topics: Acetylation; Adolescent; Adult; Arylamine N-Acetyltransferase; Caffeine; Female; Genetic Association Studies; Haplotypes; Humans; Isoenzymes; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Serbia; Uracil; Uric Acid; White People; Xanthines; Young Adult	2011
Caffeine and uric acid mediate glutathione synthesis for neuroprotection. Neuroscience, 2011, May-05, Volume: 181 Topics: Animals; Caffeine; Cell Line, Tumor; Glutathione; Humans; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Organ Culture Techniques; Oxidative Stress; Uric Acid	2011
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans. Journal of clinical pharmacology, 2012, Volume: 52, Issue:10 Topics: Arylamine N-Acetyltransferase; Asian People; Caffeine; Contraceptives, Oral; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2012
Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism. Journal of bacteriology, 2012, Volume: 194, Issue:15 Topics: Caffeine; DNA, Bacterial; Klebsiella pneumoniae; Metabolic Networks and Pathways; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Multigene Family; Oxidation-Reduction; Oxidoreductases; Protein Conformation; Pseudomonas; Sequence Analysis, DNA; Synteny; Uric Acid	2012
Simultaneous determination of uric acid, xanthine, hypoxanthine and caffeine in human blood serum and urine samples using electrochemically reduced graphene oxide modified electrode. Analytica chimica acta, 2013, Apr-10, Volume: 771 Topics: Blood Chemical Analysis; Caffeine; Catalysis; Electrochemistry; Electrodes; Graphite; Humans; Hypoxanthine; Oxidation-Reduction; Oxides; Purines; Spectrum Analysis, Raman; Time Factors; Uric Acid; Urinalysis; Xanthine	2013
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines	2014
The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort. Rheumatology international, 2015, Volume: 35, Issue:2 Topics: Aged; Caffeine; Coffee; Feeding Behavior; Female; Humans; Hyperuricemia; Male; Middle Aged; Multivariate Analysis; Regression Analysis; Republic of Korea; Risk Factors; Rural Population; Sex Distribution; Tea; Uric Acid	2015
Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats. Journal of the science of food and agriculture, 2015, Volume: 95, Issue:6 Topics: Animals; Blood Pressure; Caffeine; Camellia sinensis; Epinephrine; Hypertension; Male; Norepinephrine; Plant Extracts; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Tea; Theobromine; Uric Acid; Xanthines	2015
Theobromine inhibits uric acid crystallization. A potential application in the treatment of uric acid nephrolithiasis. PloS one, 2014, Volume: 9, Issue:10 Topics: Caffeine; Crystallization; Humans; Microscopy, Electron, Scanning; Nephrolithiasis; Oxalates; Theobromine; Uric Acid	2014
Caffeine intake and the risk of kidney stones. The American journal of clinical nutrition, 2014, Volume: 100, Issue:6 Topics: Adult; Aged; Body Mass Index; Caffeine; Calcium; Calcium Oxalate; Female; Follow-Up Studies; Humans; Incidence; Kidney Calculi; Life Style; Linear Models; Male; Middle Aged; Multivariate Analysis; Potassium; Prospective Studies; Risk Factors; Surveys and Questionnaires; Uric Acid	2014
Caffeine's antioxidant potency optically sensed with double-stranded DNA-encased single-walled carbon nanotubes. The journal of physical chemistry. B, 2015, Mar-12, Volume: 119, Issue:10 Topics: Antioxidants; Ascorbic Acid; Caffeine; DNA; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxyl Radical; Nanotubes, Carbon; Reactive Oxygen Species; Uric Acid	2015
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population. Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:3 Topics: Adolescent; Adult; Age Factors; Algorithms; Biomarkers; Biotransformation; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Food, Preserved; Humans; Male; Nigeria; Sex Characteristics; Theophylline; Uric Acid; Young Adult	2015
A comparative analysis of chemical compositions in Camellia sinensis var. puanensis Kurihara, a novel Chinese tea, by HPLC and UFLC-Q-TOF-MS/MS. Food chemistry, 2017, Feb-01, Volume: 216 Topics: Alkaloids; Caffeine; Camellia sinensis; China; Chromatography, High Pressure Liquid; Humans; Plant Leaves; Polyphenols; Tandem Mass Spectrometry; Tea; Uric Acid	2017
Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers. Drug metabolism letters, 2017, Volume: 10, Issue:4 Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Diet; Female; Genotyping Techniques; Healthy Volunteers; Humans; Male; Middle Aged; Multiplex Polymerase Chain Reaction; Phenotype; Real-Time Polymerase Chain Reaction; Saliva; Specimen Handling; Tea; Uric Acid; Xanthines	2017
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system. Neuroscience letters, 2017, 10-17, Volume: 659 Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobarbital; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles; Uric Acid; Xanthines	2017
N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians. European journal of clinical pharmacology, 2018, Volume: 74, Issue:7 Topics: Adult; Arylamine N-Acetyltransferase; Black People; Caffeine; Ethiopia; Female; Gene-Environment Interaction; Genotype; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Sweden; Uracil; Uric Acid; Xanthines	2018
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Journal of microbiology and biotechnology, 2018, Jul-28, Volume: 28, Issue:7 Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2018
Effect of Consumption of Cocoa-Derived Products on Uric Acid Crystallization in Urine of Healthy Volunteers. Nutrients, 2018, Oct-16, Volume: 10, Issue:10 Topics: Adult; Aged; Caffeine; Chocolate; Coffee; Creatinine; Crystallization; Diet; Eating; Female; Healthy Volunteers; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Oxalates; Theobromine; Uric Acid; Young Adult	2018
Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nature communications, 2020, 03-19, Volume: 11, Issue:1 Topics: Binding Sites; Biosynthetic Pathways; Caffeine; Cloning, Molecular; Crystallography, X-Ray; Evolution, Molecular; Gene Expression Regulation, Plant; Methylation; Methyltransferases; Plant Leaves; Recombinant Proteins; Tea; Transcription, Genetic; Uric Acid	2020
Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. Journal of Parkinson's disease, 2020, Volume: 10, Issue:2 Topics: Aged; Biomarkers; Caffeine; Case-Control Studies; Cross-Sectional Studies; Eating; Female; Humans; Male; Middle Aged; Parkinson Disease; Sex Factors; Uric Acid	2020
Baiyacha, a wild tea plant naturally occurring high contents of theacrine and 3″-methyl-epigallocatechin gallate from Fujian, China. Scientific reports, 2020, 06-16, Volume: 10, Issue:1 Topics: Alkaloids; Caffeine; Camellia; Catechin; China; Gallic Acid; Plant Extracts; Plant Leaves; Tea; Teas, Herbal; Uric Acid	2020
Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing caffeine, methylliberine, and theacrine pharmacokinetics in humans. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Oct-15, Volume: 1155 Topics: Alkaloids; Caffeine; Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Purines; Reproducibility of Results; Tandem Mass Spectrometry; Uric Acid	2020
Fabrication of low-cost sustainable electrocatalyst: a diagnostic tool for multifunctional disorders in human fluids. Journal of materials chemistry. B, 2020, 10-28, Volume: 8, Issue:41 Topics: Ascorbic Acid; Biosensing Techniques; Caffeine; Carbon; Catalysis; Electrochemical Techniques; Electrodes; Female; Humans; Hypoxanthine; Male; Uric Acid; Xanthine	2020
Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS. Journal of separation science, 2021, Volume: 44, Issue:23 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Theobromine; Theophylline; Uric Acid	2021
Identification of Co-Expressed Genes Related to Theacrine Synthesis in Tea Flowers at Different Developmental Stages. International journal of molecular sciences, 2021, Dec-13, Volume: 22, Issue:24 Topics: Alkaloids; Biosynthetic Pathways; Caffeine; Camellia sinensis; China; Flowers; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; Tea; Transcriptome; Uric Acid; Xanthines	2021
The Inverted U-Shaped Association of Caffeine Intake with Serum Uric Acid in U.S. Adults. The journal of nutrition, health & aging, 2022, Volume: 26, Issue:4 Topics: Aged; Caffeine; Cross-Sectional Studies; Female; Humans; Male; Nutrition Surveys; Uric Acid; White People	2022
Brushite nanoparticles based electrochemical sensor for detection of uric acid, xanthine, hypoxanthine and caffeine. Analytical biochemistry, 2022, 12-15, Volume: 659 Topics: Ascorbic Acid; Caffeine; Electrochemical Techniques; Electrodes; Humans; Hypoxanthine; Nanoparticles; Uric Acid; Xanthine	2022
A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences, 2023, Volume: 151, Issue:1 Topics: Animals; Caffeine; Cysteine; Glutathione; HEK293 Cells; Humans; Hydrogen Peroxide; Mice; Neuroblastoma; Theophylline; Uric Acid	2023
Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics. Scientific reports, 2023, 05-03, Volume: 13, Issue:1 Topics: Animals; Caffeine; Gout; Humans; Hyperuricemia; Mice; Multiomics; Tandem Mass Spectrometry; Uric Acid	2023
Simultaneous Determination of Uric Acid and Caffeine by Flow Injection Using Multiple-Pulse Amperometry. Biosensors, 2023, Jun-29, Volume: 13, Issue:7 Topics: Caffeine; Electrochemical Techniques; Electrodes; Oxidation-Reduction; Uric Acid	2023