caffeine has been researched along with theophylline in 1685 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 835 (49.55) | 18.7374 |
| 1990's | 289 (17.15) | 18.2507 |
| 2000's | 258 (15.31) | 29.6817 |
| 2010's | 242 (14.36) | 24.3611 |
| 2020's | 61 (3.62) | 2.80 |
| Authors | Studies |
|---|---|
| Ishii, A; Karasawa, A; Kawakita, T; Kubo, K; Mizumoto, H; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Ishii, A; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Ichikawa, S; Ishii, A; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Jacobson, KA; van Galen, PJ; Williams, M | 1 |
| Ishii, A; Karasawa, A; Kubo, K; Mizumoto, H; Nonaka, H; Ohno, T; Shimada, J; Suzuki, F | 1 |
| Bridson, PK; Daly, JW; Hide, I | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Daly, JW; Padgett, WL; Shamim, MT; Ukena, D | 1 |
| Bruns, RF; Christ, WJ; Ibay, AC; Schneller, SW | 1 |
| Butts-Lamb, P; Daly, JW; Padgett, W; Shamim, MT; Waters, J | 1 |
| Daly, JW; Padgett, WL; Shamim, MT | 1 |
| Daly, JW; Glennon, RA; Padgett, W; Tejani-Butt, SM | 1 |
| Daly, JW | 1 |
| Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL | 1 |
| Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Martini, C; Messini, L; Senatore, G | 1 |
| Grahner, B; Lanzner, W; Müller, CE; Winiwarter, S | 1 |
| Fuse, E; Ichikawa, S; Ishii, A; Kobayashi, H; Nakamura, J; Nonaka, H; Shimada, J; Shiozaki, S; Suzuki, F | 1 |
| Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Kiriasis, L; Manning, M; Müller, C; Neumeyer, JL; Pfleiderer, W; Shi, D | 1 |
| Frobenius, W; Geis, U; Hipp, J; Müller, CE; Pawłowski, M; Sandoval-Ramírez, J; Schobert, U; Suzuki, F | 1 |
| Eder, C; Frobenius, W; Herderich, M; Müller, CE; Proksch, P; Schupp, P; Steube, K; van Soest, RW; Wray, V | 1 |
| Brufani, M; Cavallaro, RA; Filocamo, L; Galione, A; Galuppi, A; Genazzani, AA | 1 |
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| IJzerman, AP; Ingkaninan, K; Verpoorte, R | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE | 1 |
| Daly, JW; Diekmann, M; Jacobson, KA; Müller, CE; Padgett, WL; Qurishi, R; Thorand, M | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Borea, PA; Dalpiaz, A; Gilli, G; Gilli, P; Scatturin, A; Varani, K | 1 |
| Andersen, OA; Demartino, JA; Rao, FV; van Aalten, DM; Vora, KA | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Gwizdek-Wiśniewska, A; Piosik, J; Ulanowska, K; Wegrzyn, G | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Bertarelli, DC; Diekmann, M; Hayallah, AM; Iqbal, J; Müller, CE; Preiss, B; Rüsing, D; Verspohl, EJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Bearne, SL; Lunn, FA; Roy, AC | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| El-Tayeb, A; Inamdar, GS; Li, W; Müller, CE; Scheiff, AB; Sudarsanam, V; Vasu, KK; Yerande, SG | 1 |
| Cheng, F; Liu, G; Tang, Y; Xu, Z | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Copits, B; Frausto, S; Gill, MB; Noguchi, K; Sakai, R; Sakurada, T; Shimamoto, K; Swanson, GT | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Andrews, SP; Congreve, M; Errey, JC; Marshall, FH; Mason, JS; Robertson, N; Tehan, B; Weir, M; Zhukov, A | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L | 1 |
| Gołuński, G; Iermak, I; Piosik, J; Rychłowski, M; Woziwodzka, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Akkari, R; Borrmann, T; Brunschweiger, A; Drabczyńska, A; Hockemeyer, J; Kieć-Kononowicz, K; Koch, P; Köse, M; Küppers, P; Müller, CE; Radjainia, H; Schlenk, M | 1 |
| de Lera Ruiz, M; Lim, YH; Zheng, J | 1 |
| Al-Nadaf, AH; Al-Sha'er, MA; Khanfar, MA; Taha, MO | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Hurley, TD; Morgan, CA | 1 |
| Chan, KL; Lee, CY; Liew, KF | 1 |
| Azuaje, J; Carbajales, C; Crespo, A; El Maatougui, A; Escalante, L; García-Mera, X; González-Gómez, M; Gutiérrez-de-Terán, H; Miguez, G; Sotelo, E | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Doroż-Płonka, A; Drabczyńska, A; Handzlik, J; Hinz, S; Karcz, T; Kieć-Kononowicz, K; Latacz, G; Müller, CE; Schabikowski, J; Stanuch, K; Szymańska, E; Załuski, M | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P | 1 |
| Cheng, M; Guo, J; Jiang, N; Li, Q; Liang, N; Liu, J; Nong, X; Pang, C; Qin, Y; Tang, C; Tang, W; Xie, SS; Zhang, Z | 1 |
| Cheng, M; Fang, Y; Guo, J; Jin, Y; Liu, J; Wan, Y; Wang, R; Xie, SS; Zhang, Z; Zhou, W | 1 |
| Atkinson, BN; Bayle, ED; Fish, PV; Steadman, D; Svensson, F; Vincent, JP; Whiting, P; Willis, NJ; Woodward, HL | 1 |
| Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A | 1 |
| Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G | 1 |
| Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW | 1 |
| Berizzi, A; Bird, L; Culurgioni, S; Navratilova, IH; Olsen, RHJ; Rawlins, PB; Robinson, S; Shepherd, C; Thompson, LEJ; Varzandeh, S | 1 |
| Frantsuzova, SB | 2 |
| Helle, KB; Storesund, A | 1 |
| Arold, R; Chilla, R | 1 |
| Kostopoulos, GK; Phillis, JW | 1 |
| Morishima, I | 2 |
| Chatterjee, SK; Kim, U | 1 |
| Amelar, RD; Dubin, L; Schoenfeld, C | 1 |
| Cohn, M; Cohn, ML; Kraynack, BJ; Taylor, FH | 1 |
| Berry, MS; Pentreath, VW | 1 |
| Filburn, CR; Karn, J; Wyatt, GR | 1 |
| Collins, C; Richards, PT; Starmer, GA | 1 |
| Johno, I; Kitazawa, S; Minouchi, T; Okada, J | 1 |
| Connett, RJ | 1 |
| Sacks, LE; Thompson, PA | 2 |
| Boross, M; Holló, I | 1 |
| Barbara, L; Borghi, E; Casadio, R; Corinaldesi, R; Paparo, GF; Stanghellini, V; Tonon, R | 1 |
| Kimura, T; Muranishi, S; Nakamura, J; Sezaki, H; Takamura, R | 1 |
| Eiceman, GA; Otto, JL; Walton, HF | 1 |
| Chan, YH; Curtis-Prior, PB; Gibbons, JR | 1 |
| Aranda, JV; Baltassat, P; Bethenod, M; Bory, C; Frederich, A; Porthault, M | 2 |
| Boutroy, MJ; Monin, P; Royer, RJ; Royer-Morrot, MJ; Vert, P | 2 |
| Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A | 1 |
| Goz, B; Wharton, W | 3 |
| Mizutani, A; Sugimura, K | 1 |
| Garcia, L; Rogers, BJ | 1 |
| Lehnert, S | 1 |
| Reddy, EP; Sarma, PS; Schulz, RA; Srinivasan, A | 1 |
| Edstrom, JP; Kirkpatrick, JR; Kostopoulos, GK; Phillis, JW | 1 |
| Singh, M | 1 |
| Mircevová, L; Simmonová, A; Viktora, L | 1 |
| Fujiwara, M; Oishi, R; Razzak, A; Ueki, S | 1 |
| Breuiller, M; Cedard, L; Ferre, F | 2 |
| Bayless, TM; Brady, PG | 1 |
| Collier, HO; Francis, DL; Roy, AC | 2 |
| Andoh, T; Anzai, K; Ide, T | 1 |
| Duncan, PE; Griffin, JP; Solomon, SS | 1 |
| Cake, MH; Litwack, G | 2 |
| Bieck, P; Neuvonen, PJ; Vapaatalo, H; Westermann, E | 1 |
| Howell, SL; Montague, W; Tyhurst, M | 1 |
| Feldman, JF | 1 |
| Tsuboi, M; Yanagishima, N | 2 |
| Dickens, MS; Lucas-Leonard, J; Roth, JS | 1 |
| Fink, CJ; Lacy, PE; McDaniel, ML; Roth, C | 1 |
| Mattocks, AM; Wesley-Hadzija, B | 1 |
| Newburgh, RW; Tsuzuki, J | 1 |
| Nishigaki, I; Ohama, H; Okumura, M; Yagi, K | 1 |
| Beatty, CH; Bocek, RM | 1 |
| Karelin, AA; Mardashev, SR | 1 |
| Gelman, DB; Hayes, DK; Schechter, MS | 1 |
| Claycomb, WC | 1 |
| Kahan, BD; Mittal, KK; Pincus, JH | 1 |
| Beatty, CH; Bocek, RM; Novy, MJ; Young, MK | 1 |
| Ehmann, UK; Gehring, U; Tomkins, GM | 1 |
| Furihata, C; Matsushima, T; Sugimura, T; Terai, M | 1 |
| Erlij, D; Grinstein, S | 1 |
| Braun, R; Trevithick, JR | 1 |
| Franks, DJ; Hamet, P; Horrobin, DF; Manku, MS | 1 |
| Garbers, DL | 1 |
| Scarpelli, DG; Tomita, T | 1 |
| Bockaert, J; Perez, M; Premont, J | 1 |
| Ozato, K | 1 |
| Coult, DB; Wilkinson, RG | 1 |
| Asano, T; Hidaka, H; Ochiai, Y | 1 |
| Buckley, JT | 1 |
| Finlayson, LH; Osborne, MP | 1 |
| Cagan, RH | 1 |
| Davidson, D; Stallwood, GR | 1 |
| Bruyere, HJ; Cheung, MO; Gilbert, EF; Hodach, RJ; Ishikawa, S | 1 |
| Dodd, G; Menevse, A; Poynder, TM | 1 |
| Breuiller, M; Cedard, L; de Pariente, D; Ferre, F | 1 |
| De Mello, WC | 1 |
| Kostellow, AB; Morrill, GA; Poupko, JM; Schatz, F | 1 |
| Higgens, CE; Somers, PJ | 1 |
| Kirkpatrick, JR; Phillis, JW | 1 |
| Lowitt, S; Polson, JB; Szentivanyi, A; Williams, JF | 1 |
| Latarjet, R; Zajdela, F | 2 |
| Grakhovska, T; Petkov, V; Stancheva, S; Uzunov, P | 1 |
| Buse, E; Ebert, F; Walter, RD | 1 |
| Butt, NM; Collier, HO; Cuthbert, NJ; Francis, DL; Saeed, SA | 1 |
| Correze, C; Krug, E; Nunez, J; Verhaegen, M | 1 |
| Soyka, LF | 2 |
| Kidder, GW; Nolan, LL | 1 |
| Goz, B; Hart, CA; Wharton, W | 1 |
| Stefanovich, V | 2 |
| Coret, IA; Hughes, MJ | 1 |
| Balls, M; Gater, S | 1 |
| Dewey, WC; Tomasovic, SP | 1 |
| Connett, RJ; Hays, ET | 1 |
| Brown, L; Horning, MG; Kellaway, P; Lertratanangkoon, K; Nowlin, J; Zion, TE | 1 |
| Dascombe, MJ | 1 |
| Fink, CJ; Lacy, PE; McDaniel, ML; Roth, CE; Swanson, JA; Weaver, DC | 1 |
| Brodsky, B; Koup, JR | 1 |
| Aranda, JV; Turmen, T | 1 |
| Bry, CG; Fink, CJ; Homer, RW; Lacy, PE; McDaniel, ML | 1 |
| Maziére, C; Maziére, JC | 1 |
| Brazier, JL; Renaud, H; Ribon, B; Salle, BL | 1 |
| Lin, CI; Vassalle, M | 1 |
| Gan, IE; Schier, GM | 1 |
| Bada, HS; Khanna, NN; Somani, SM; Tin, AA | 1 |
| Götz von Olenhusen, KG; Wohlfarth-Bottermann, KE | 1 |
| Farkas, CS | 1 |
| Allan, WC; Volpe, JJ | 1 |
| Baltassat, P; Bory, C; Frederich, A; Hartmann, E | 1 |
| Alberola, S; Jeanjean, B; Sabon, F; Terol, A | 1 |
| Shoyab, M | 1 |
| O'Neill, FJ | 1 |
| Aldridge, A; Aranda, JV; Haber, R; Louridas, AT; Thom, P; Vitullo, BB | 1 |
| Dettmer, D; Glander, HJ | 1 |
| Nielsen-Kudsk, F; Pedersen, AK | 1 |
| Jhamandas, K; Sawynok, J; Sutak, M | 1 |
| Riechert, M | 1 |
| Al-Ani, NI; Borazan, HN | 2 |
| Ido, T; Iwata, R; Kasida, Y; Saji, H; Suzuki, K; Tamate, K; Yoshikawa, K | 1 |
| Göber, B; Kraft, R | 1 |
| Timson, J | 2 |
| Syed, IB | 1 |
| Kihlman, BA; Sturelid, S | 1 |
| Allewell, NM; Oles, J; Wolfe, J | 1 |
| Cockett, AT; Dougherty, KA; Urry, RL | 1 |
| Limpavithayakul, K; Lolikha, PH | 1 |
| Dich, J; Gluud, CN | 1 |
| Price, NR; Williams, AJ | 1 |
| Sved, S; Wilson, DL | 1 |
| Hossie, RD; McGilveray, IJ; Midha, KK; Sved, S | 1 |
| Ohkawa, H; Watanabe, M | 1 |
| Charles, BG; Rawal, BD | 2 |
| Beubler, E; Lembeck, F | 1 |
| Amerson, E; Cook, CE; Kepler, JA; Myers, M; Taylor, GF; Twine, ME | 1 |
| Turner, T; Vasiliades, J | 1 |
| Pichler, O; Studlar, M | 1 |
| Kakac, B; Ryska, M; Sarsunova, M | 1 |
| Chae, YS; Shelver, WH | 1 |
| Chiou, WL; Peng, A; Peng, GW; Smith, V | 1 |
| Hoffmann, A; Siegers, CP; Sierra-Callejas, JL; Strubelt, O | 1 |
| Brunetti, T; Capolsini Secca, T; Ciucci Dolcini, BM; Dolcini, C; Fanò, G; Menchetti, O | 1 |
| Ivy, N; Jemiolo, D; Mellon, M; Nath, J; Rebhun, LI | 1 |
| Katz, ML; Kazmer, S; Mauer, I; Weinstein, D | 1 |
| Lucey, JF | 1 |
| Dusci, LJ; Hackett, LP; McDonald, IA | 1 |
| Agnati, LF; Corrodi, H; Everitt, BJ; Fuxe, K; Hökfelt, T; Löfström, A; Ungerstedt, U | 1 |
| Gombe, S; Norman, C | 1 |
| Aeschbacher, HU; Würzner, HP | 1 |
| Wildanger, W | 1 |
| Lehmann, AR; Nilsson, K | 1 |
| Frings, CS; Keefer, RC; Saloom, JM | 1 |
| Chapman, RA; Leoty, C | 1 |
| Holzhey, P | 1 |
| Franconi, LC; Haney, WG; Hawk, GL; Sandmann, BJ | 1 |
| Hossie, RD; McGilveray, IJ; Sved, S | 1 |
| Johnson, GF; Least, CJ; Solomon, HM | 1 |
| Evenson, MA; Warren, BL | 1 |
| Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S | 1 |
| Gonzalez, FJ; Gu, L; Kalow, W; Tang, BK | 1 |
| Hiratsuka, E; Imamura, S; Kimura, M; Matsuoka, R; Takao, A | 1 |
| Gadd, GM; Sabie, FT | 1 |
| Hodgkiss, RJ; Kelleher, E; Parrick, J | 1 |
| Suzuki, R; Yoshino, H | 1 |
| Andersson, HC; Kihlman, BA | 1 |
| Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D | 1 |
| Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y | 1 |
| Lerner, UH; Mellström, D | 1 |
| Dean, PM; Edwardson, JM | 1 |
| Duenas, J; Elizalde, A; Huerta, M; Muñiz, J; Trujillo, X | 1 |
| Asahi, T; Kuribara, H; Tadokoro, S | 1 |
| Anders, EM; Fuhr, U; Mahr, G; Sörgel, F; Staib, AH | 1 |
| Cayre, I; Frutos, G; González-Jimènez, J | 1 |
| Desta, Z; Steingruber, M | 1 |
| Arizono, K; Brady, FO; Garrett, SH; Xiong, X | 1 |
| Carnevale, A; Chiarotti, M; De Carolis, MP; De Giovanni, N; Muzii, U; Romagnoli, C; Tortorolo, G; Zecca, E | 1 |
| Dudley, MN; Marchbanks, CR; Radandt, JM | 1 |
| Blanchard, J; Shearer, LE; Weber, CW | 2 |
| Robson, RA | 1 |
| Brown, SS; Chin, KC; Durbin, GM; Hale, KA; Morgan, ME; Scanlon, JE | 1 |
| Kuribara, H; Tadokoro, S | 1 |
| Alsar, MJ; Sacristan, JA; Soto, J | 1 |
| Fuhr, U; Roots, I; Rost, KL; Staib, AH | 1 |
| Tanaka, E | 1 |
| Misawa, M; Suzuki, T; Tuazon, DB; Watanabe, S | 1 |
| Alderfer, JL; Brickmann, JA; Danilov, VI; Lautenschlager, P; Poltev, VI; Slyusarchuk, ON; Wollman, RM | 1 |
| Caslavska, J; Gebauer, P; Minger, A; Molteni, S; Thormann, W | 1 |
| Mante, S; Minneman, KP | 1 |
| Ajiro, K; Nishikawa, Y; Shibata, K | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Gellert, M; Menetski, JP | 1 |
| Belan, PV; Kostyuk, PG; Tepikin, AV | 1 |
| Battula, N; Doehmer, J; Fuhr, U; Keita, Y; Kudla, C; Staib, AH; Wölfel, C | 1 |
| Huddart, H; Lynch, M | 1 |
| Moncrieff, J | 1 |
| Jackson, SH; Maskray, V; Swift, CG; Tiplady, B; Yu, G | 1 |
| Levi-Schaffer, F; Touitou, E | 1 |
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| Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J | 1 |
| Daali, Y; Desmeules, J; Magliocco, G; Samer, CF; Thomas, A | 1 |
| Bryce, DL; Southern, SA | 1 |
| Bai, L; Chen, Z; Cheng, X; Ding, Y; Hu, M; Hu, X; Hu, Y; Huang, Y; Li, H; Liao, R; Qu, W; She, ZG; Tian, S; Wan, J; Xue, J; Zhang, X; Zhang, XJ; Zhang, Y; Zhao, J; Zou, T | 1 |
| Kinzig, M; Pietrzak-Fiećko, R; Purkiewicz, A; Sörgel, F | 1 |
| Dirikolu, L; Göktaş, EF; Güneş, E; Kabil, E; Yatanaslan, L | 1 |
| Chen, F; Cheng, R; Dai, HR; Ding, XS; Du, FF; Guo, HL; Hu, YH; Long, JY; Tian, M; Xia, Y; Xu, J | 1 |
| Labas, SR; Liu, J | 1 |
| Aoyama, K; Bhadhprasit, W; Kinoshita, C; Matsumura, N; Nakaki, T | 1 |
| Cao, D; Han, R; Liu, D; Wan, Z; Wang, Y; Xie, F; Yu, Z; Zeng, N | 1 |
| Eguchi, H; Endo, S; Ikari, A; Ito, A; Kimura, R; Matsunaga, T; Onuma, S; Yoshino, Y; Yu, Y | 1 |
| Liu, M; Luo, J; Xie, R; Zhang, Y; Zheng, Z | 1 |
| Arlt, C; Günther, WF; Hüttelmaier, S; Kipping, M; Lederer, M; Merkenschlager, A; Sinz, A; Tänzler, D | 1 |
| Beardsley, PM; Elder, HJ; Walentiny, DM | 1 |
| Ding, Y; Huang, PJ; Li, AZ; Liu, J; Xie, Y | 1 |
| Aoyama, K; Matsumura, N | 1 |
| Dieckmann, T; Evans, NM; Huang, PJ; Li, AZ; Liu, J; Lu, C | 1 |
| Bortolami, M; Curulli, A; Di Matteo, P; Feroci, M; Petrucci, R; Trani, A | 1 |
| Bruschettini, M; Marques, KA; Moresco, L; Sjögren, A; Soll, R | 1 |
| Liu, M; Shen, W; Tan, N; Tang, M; Zhang, Y | 1 |
112 review(s) available for caffeine and theophylline
| Article | Year |
|---|---|
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship | 1992 |
Adenosine receptors: targets for future drugs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1982 |
Fluorescent ligands for adenosine receptors.
Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 2013 |
Adenosine A2A receptor as a drug discovery target.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction | 2014 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship | 2022 |
[Parotid secretion and its pharmacologically induced variants (author's transl)].
Topics: Adrenergic beta-Antagonists; Amylases; Animals; Antihypertensive Agents; Caffeine; Cyclic AMP; Dinitrophenols; Humans; Nicotine; Oxidative Phosphorylation; Parotid Gland; Receptors, Adrenergic; Sialadenitis; Sympathomimetics; Theophylline | 1975 |
Opiates, cyclic nucleotides, and xanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caffeine; Cyclic AMP; Dopamine; Enzyme Activation; Humans; Lung; Morphine; Narcotics; Prostaglandins E; Theophylline; Xanthines | 1976 |
Effects of methylxanthines on the fetus.
Topics: Animals; Caffeine; Cyclic AMP; Female; Fetus; Humans; Intestinal Absorption; Kinetics; Labor, Obstetric; Lung; Maternal-Fetal Exchange; Pregnancy; Respiration; Theophylline; Xanthines | 1979 |
Methylxanthines in apnea of prematurity.
Topics: Apnea; Caffeine; Hemodynamics; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Respiration; Theophylline | 1979 |
Theobromine and theophylline.
Topics: Animals; Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosomes; Drosophila; Escherichia coli; Humans; Mice; Mitosis; Mutagens; Mutation; Rats; Structure-Activity Relationship; Theobromine; Theophylline | 1975 |
The effects of caffeine.
Topics: Adult; Arteriosclerosis; Caffeine; Child, Preschool; Female; Humans; Hypersensitivity; Infant; Male; Middle Aged; Theobromine; Theophylline; Time Factors | 1976 |
Regulation of the in vivo mitotic apparatus by glycols and metabolic inhibitors.
Topics: Aminophylline; Animals; Bivalvia; Brain; Caffeine; Calcium; Colchicine; Dinitrophenols; Female; Glycols; Microtubules; Mitosis; Organoids; Ovum; Rabbits; Sea Urchins; Theophylline; Tubulin; Xanthines | 1975 |
Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management.
Topics: Absorption; Antacids; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interactions; Food; Humans; Metronidazole; Theophylline | 1992 |
The effects of quinolones on xanthine pharmacokinetics.
Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Drug Interactions; Humans; Theophylline; Xanthines | 1992 |
Pharmacotherapy of neonatal apnea.
Topics: Apnea; Caffeine; Citrates; Doxapram; Drug Combinations; Humans; Infant, Newborn; Theophylline | 1991 |
[Gyrase inhibitors. Central nervous side effects and inhibition of methylxanthine elimination].
Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Central Nervous System; Drug Interactions; Drug Synergism; Humans; Theophylline; Xanthines | 1990 |
Adverse reactions and interactions of fluoroquinolones.
Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Drug Interactions; Humans; Intestinal Absorption; Mutagens; Theophylline | 1989 |
Drug-drug interactions with ciprofloxacin and other fluoroquinolones.
Topics: Antacids; Caffeine; Ciprofloxacin; Cyclosporins; Drug Interactions; Humans; Intestinal Absorption; Rifampin; Theophylline | 1989 |
Effects of enprofylline and theophylline may show the role of adenosine.
Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesterified; Gastric Acid; Heart; Humans; Kidney; Kinetics; Lung; Natriuresis; Phosphodiesterase Inhibitors; Receptors, Cell Surface; Receptors, Purinergic; Respiration; Seizures; SRS-A; Theophylline; Vasoconstriction; Vasodilation; Xanthines | 1986 |
Pharmacotherapy of respiratory muscles.
Topics: Animals; Caffeine; Humans; Muscle Contraction; Respiratory Insufficiency; Respiratory Muscles; Stimulation, Chemical; Sympathomimetics; Theophylline | 1988 |
Pharmacologic effects of theophylline in the newborn.
Topics: Animals; Animals, Newborn; Brain; Caffeine; Cardiovascular System; Digestive System; Hormones; Humans; Infant, Newborn; Kidney; Respiratory System; Theophylline | 1986 |
[Nucleotide metabolism and gastric acid secretion].
Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Cortisone; Cyclic AMP; Depression, Chemical; Dogs; Epinephrine; Gastric Juice; Gastric Mucosa; Glucocorticoids; Guinea Pigs; Histamine Release; Humans; Hydrazines; Imidazoles; In Vitro Techniques; Phentolamine; Phosphates; Phosphoric Monoester Hydrolases; Prednisolone; Propiophenones; Prostaglandins; Rabbits; Rats; Stimulation, Chemical; Sympatholytics; Theobromine; Theophylline; Vasodilator Agents | 1970 |
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines; DNA; DNA Repair; DNA Replication; DNA, Single-Stranded; Floxuridine; Hydroxyurea; Mitosis; Models, Biological; Mutagens; Radiation Genetics; Recombination, Genetic; Streptonigrin; Theobromine; Theophylline | 1974 |
Cyclic nucleotide phosphodiesterase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Brain; Caffeine; Cyclic AMP; Diphosphates; Enzyme Activation; Insulin; Kinetics; Magnesium; Manganese; Molecular Weight; Phosphoric Monoester Hydrolases; Theophylline; Trypsin | 1970 |
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.
Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Phentolamine; Propranolol; Receptors, Adrenergic; Stress, Physiological; Sympathetic Nervous System; Theophylline | 1973 |
The positive inotropic effect of cyclic AMP.
Topics: Aminophylline; Animals; Butyrates; Caffeine; Cyclic AMP; Epinephrine; Glucagon; Guinea Pigs; Heart; Histamine; Isoproterenol; Lysergic Acid Diethylamide; Models, Biological; Muscle Contraction; Myocardium; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Rats; Theophylline; Time Factors; Tritium | 1972 |
Cyclic nucleotides in higher plants?
Topics: Adenine; Adenosine; Adenylyl Cyclases; Caffeine; Cyclic AMP; Gibberellins; Phosphoric Diester Hydrolases; Plant Growth Regulators; Plants; Protein Kinases; Theophylline | 1974 |
Drug treatment in bronchial asthma.
Topics: Acetylcysteine; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Caffeine; Drug Combinations; Ephedrine; Epinephrine; Expectorants; Glucocorticoids; Guaifenesin; Humans; Hypertension; Isoproterenol; Mucus; Sympathomimetics; Theophylline; Xanthines | 1973 |
Effects of caffeine on the genetic material.
Topics: Alkylating Agents; Animals; Ascomycota; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Coffee; DNA Replication; Drug Synergism; Environmental Exposure; Escherichia coli; Humans; Meiosis; Mutagens; Mutation; Radiation Effects; Tea; Theophylline; Ultraviolet Rays | 1974 |
Gastrointestinal and metabolic effects of methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Caffeine; Calcium; Carbohydrate Metabolism; Digestive System; Energy Metabolism; Esophagus; Gastric Acid; Humans; Lipid Metabolism; Lipolysis; Liver; Pancreas; Saliva; Theophylline; Thyroid Gland; Xanthines | 1984 |
Effects of methylxanthines on skeletal muscle and on respiration.
Topics: Animals; Caffeine; Histamine Release; Muscle Contraction; Muscles; Respiration; Theobromine; Theophylline | 1984 |
Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System; Cyclic AMP; Humans; Neurotransmitter Agents; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Xanthines | 1981 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline | 1984 |
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Isoenzymes; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 1981 |
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Caffeine; Cells, Cultured; Humans; Kinetics; Leukemia; Lymphocyte Activation; Lymphocytes; Reference Values; Theophylline | 1984 |
The neuropharmacology of various diazepam antagonists.
Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline | 1983 |
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Kinetics; Male; Methylation; Pulmonary Edema; Theophylline; Tissue Distribution | 1983 |
Caffeine: implications of recent research for clinical practice.
Topics: Abnormalities, Drug-Induced; Affective Symptoms; Animals; Blood Pressure; Brain; Caffeine; Child; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Male; Motor Activity; Pregnancy; Stimulation, Chemical; Substance-Related Disorders; Theophylline | 1984 |
Analytical methods for quantitation of methylxanthines.
Topics: Animals; Body Fluids; Caffeine; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Food Analysis; Humans; Methods; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1984 |
Human disposition and some biochemical aspects of methylxanthines.
Topics: Caffeine; Contraceptives, Oral; Female; Humans; Intestinal Absorption; Kinetics; Male; Theobromine; Theophylline; Tissue Distribution | 1984 |
Action of the methylxanthines on the pituitary and pituitary-dependent hormones.
Topics: Adrenal Glands; Animals; Caffeine; Female; Growth Hormone; Humans; Male; Pituitary Gland; Prolactin; Theobromine; Theophylline; Thyroid Gland; Thyrotropin; Time Factors | 1984 |
Introduction to the chemistry, isolation, and biosynthesis of methylxanthines.
Topics: Cacao; Caffeine; Chemical Phenomena; Chemistry; Coffee; Tea; Theobromine; Theophylline | 1984 |
The chemical components of coffee.
Topics: Alkaloids; Caffeine; Carbohydrates; Coffee; Hydrocarbons; Lipids; Mycotoxins; Nitrogen; Pesticides; Phenols; Sulfur; Theobromine; Theophylline; Vitamins | 1984 |
The toxicology of cocoa and methylxanthines: a review of the literature.
Topics: Animals; Cacao; Caffeine; Diet; Female; Fetus; Fibrocystic Breast Disease; Humans; Mutagenicity Tests; Plants, Edible; Reproduction; Theobromine; Theophylline; Tissue Distribution; Xanthines | 1982 |
The biochemistry and technology of tea manufacture.
Topics: Alkaloids; Caffeine; Catechin; Fermentation; Food Handling; Food Technology; Hot Temperature; Nitrogen; Oils, Volatile; Plant Proteins; Species Specificity; Tannins; Tea; Theobromine; Theophylline | 1980 |
Transdermal delivery and the premature neonate.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Caffeine; Drug Delivery Systems; Female; Humans; Infant, Newborn; Infant, Premature; Injections, Intravenous; Male; Skin; Skin Absorption; Theophylline | 1994 |
Receptor mechanisms of bitter substances.
Topics: Amino Acid Sequence; Animals; Caffeine; GTP-Binding Proteins; Humans; Molecular Sequence Data; Quinine; Receptors, Cell Surface; RNA, Messenger; Strychnine; Synaptic Transmission; Taste; Taste Buds; Theophylline | 1994 |
Pharmacological stimulation of sperm motility.
Topics: Caffeine; Deoxyadenosines; Humans; Infertility, Male; Male; Pentoxifylline; Relaxin; Sperm Motility; Theophylline | 1994 |
Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine.
Topics: Adolescent; Adolescent Behavior; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Child; Child Behavior; Cognition; Female; Humans; Male; Theophylline | 1996 |
Pharmacologic management of apnea of prematurity.
Topics: Apnea; Bronchodilator Agents; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline | 1996 |
Pharmacokinetic interactions related to the chemical structures of fluoroquinolones.
Topics: Aluminum Hydroxide; Animals; Anti-Infective Agents; Caffeine; Drug Interactions; Fluoroquinolones; Humans; Molecular Structure; Quinolones; Rats; Structure-Activity Relationship; Theophylline | 1996 |
Standards of laboratory practice: theophylline and caffeine monitoring. National Academy of Clinical Biochemistry.
Topics: Apnea; Bronchodilator Agents; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Lung Diseases, Obstructive; Quality Control; Specimen Handling; Theophylline | 1998 |
[Pharmacokinetic interactions between fluoroquinolones and methylxanthines].
Topics: Anti-Infective Agents; Caffeine; Drug Interactions; Fluoroquinolones; Humans; Methylation; Theophylline; Xanthines | 1999 |
Caffeine versus theophylline for apnea in preterm infants.
Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline | 2000 |
Prophylactic methylxanthine for extubation in preterm infants.
Topics: Caffeine; Central Nervous System Agents; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Intubation, Intratracheal; Theophylline; Vasodilator Agents; Ventilator Weaning; Xanthines | 2000 |
Methylxanthine treatment for apnea in preterm infants.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Vasodilator Agents; Xanthines | 2000 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Stroke; Theophylline; Vasodilator Agents | 2000 |
Current options in the management of apnea of prematurity.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Doxapram; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Xanthines | 2000 |
[Simultaneous determination of theophylline and its metabolites by HPLC].
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Sensitivity and Specificity; Theophylline; Xanthines | 2000 |
Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Dogs; Humans; Mice; Models, Biological; Pharmacokinetics; Probability; Rabbits; Rats; Reproducibility of Results; Risk Assessment; Species Specificity; Substrate Specificity; Theobromine; Theophylline | 2001 |
Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
Topics: Adult; Aged; Area Under Curve; Caffeine; Child; Cytochrome P-450 CYP1A2; Humans; Infant, Newborn; Models, Biological; Pharmacokinetics; Probability; Reproducibility of Results; Risk Assessment; Substrate Specificity; Theobromine; Theophylline; Warfarin | 2001 |
Methylxanthine treatment for apnea in preterm infants.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Vasodilator Agents; Xanthines | 2001 |
Theophylline or caffeine: which is best for apnea of prematurity?
Topics: Apnea; Caffeine; Citrates; Drug Combinations; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male; Theophylline; Treatment Outcome | 2000 |
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.
Topics: Amphetamine; Amphetamines; Benzphetamine; Caffeine; Furans; Humans; Methamphetamine; Molecular Structure; Prenylamine; Prodrugs; Pyrazoles; Pyrazolones; Selegiline; Substance Abuse Detection; Sydnones; Theophylline | 2002 |
The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent.
Topics: Aminophylline; Animals; Caffeine; Ephedrine; Humans; Obesity; Plant Preparations; Theophylline; Weight Loss | 2001 |
Augmentation of seizure induction in electroconvulsive therapy: a clinical reappraisal.
Topics: Anesthetics; Caffeine; Electroconvulsive Therapy; Humans; Oxygen; Psychotropic Drugs; Theophylline | 2002 |
Prophylactic methylxanthines for extubation in preterm infants.
Topics: Caffeine; Central Nervous System Agents; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Intubation, Intratracheal; Randomized Controlled Trials as Topic; Theophylline; Time Factors; Vasodilator Agents; Ventilator Weaning; Xanthines | 2003 |
Treatment of apnea of prematurity.
Topics: Aminophylline; Apnea; Caffeine; Clinical Trials as Topic; Doxapram; Humans; Infant, Newborn; Infant, Premature; Respiratory System Agents; Theophylline | 2003 |
[CATECHOLAMINES AND CARDIAC MUSCLE].
Topics: Acetylcholine; Adenine Nucleotides; Caffeine; Calcium; Catecholamines; Glycogen; Guanethidine; Heart; Hyperthyroidism; Isoproterenol; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Perfusion; Pharmacology; Phosphorylase Kinase; Piperazines; Research; Reserpine; Strophanthins; Sympathetic Nervous System; Theophylline; Tyramine | 1963 |
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic Clearance Rate; Models, Biological; Risk Factors; Theophylline; Tissue Distribution | 2004 |
Methylxanthines for the treatment of apnea associated with bronchiolitis and anesthesia.
Topics: Anesthesia, General; Apnea; Bronchiolitis; Caffeine; Clinical Trials as Topic; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Respiratory System Agents; Theophylline | 2004 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Randomized Controlled Trials as Topic; Stroke; Theophylline; Vasodilator Agents | 2004 |
Assessment of CYP1A2 activity in clinical practice: why, how, and when?
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Induction; Genotype; Humans; Liver; Pharmaceutical Preparations; Phenotype; Saliva; Theophylline | 2005 |
Drug interactions and smoking: raising awareness for acute and critical care providers.
Topics: Acute Disease; Adrenergic beta-Antagonists; Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Anticoagulants; Caffeine; Critical Care; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Drug Resistance; Humans; Liver; Metabolic Clearance Rate; Nurse's Role; Nursing Assessment; Prevalence; Psychotropic Drugs; Smoking; Theophylline; United States | 2006 |
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.
Topics: Administration, Oral; ATP-Binding Cassette Transporters; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Pharmaceutical Preparations; Phenotype; Theophylline; Tolbutamide | 2007 |
Drug interactions with smoking.
Topics: Benzodiazepines; Caffeine; Clozapine; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Drug Interactions; Humans; Olanzapine; Smoking; Theophylline | 2007 |
Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
Topics: Administration, Oral; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Clinical Trials as Topic; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Midazolam; Mixed Function Oxygenases; Modafinil; Pharmaceutical Preparations; Theophylline | 2008 |
[Coffee and cancer].
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Anticarcinogenic Agents; Caffeine; Cell Transformation, Neoplastic; Coffee; Female; Humans; Lymphocyte Activation; Male; Mice; Mice, Transgenic; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Adenosine A2; Theobromine; Theophylline | 2008 |
Effects of caffeine and theophylline on coronary hyperemia induced by adenosine or dipyridamole.
Topics: Adenosine; Animals; Caffeine; Coronary Circulation; Coronary Disease; Dipyridamole; Drug Administration Schedule; Drug Interactions; Echocardiography, Doppler; Humans; Hyperemia; Myocardial Perfusion Imaging; Positron-Emission Tomography; Practice Guidelines as Topic; Predictive Value of Tests; Theophylline; Time Factors; Vasodilator Agents | 2009 |
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissue Growth Factor; Humans; Liver; Liver Neoplasms; Proteasome Endopeptidase Complex; Smad2 Protein; Theophylline; Transforming Growth Factor beta; Xanthines | 2009 |
Caffeine versus theophylline for apnea in preterm infants.
Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Theophylline | 2010 |
Distribution, biosynthesis and catabolism of methylxanthines in plants.
Topics: Amino Acid Sequence; Cacao; Caffeine; Camellia; Coffea; Methyltransferases; Molecular Sequence Data; Plants; Theophylline; Xanthines | 2011 |
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Catalytic Domain; Drug Design; Humans; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 2011 |
Xanthines as adenosine receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Caffeine; Humans; Purinergic P1 Receptor Antagonists; Species Specificity; Structure-Activity Relationship; Theophylline; Xanthines | 2011 |
Methylxanthines, seizures, and excitotoxicity.
Topics: Adenosine; Animals; Caffeine; Humans; Neurotoxins; Seizures; Theophylline; Xanthines | 2011 |
Methylxanthines and the kidney.
Topics: Animals; Caffeine; Contrast Media; Diuresis; Hemodynamics; Humans; Kidney; Natriuresis; Renin; Theophylline | 2011 |
Methylxanthines and inflammatory cells.
Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theophylline | 2011 |
Methylxanthine treatment for apnoea in preterm infants.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Randomized Controlled Trials as Topic; Theophylline; Vasodilator Agents; Xanthines | 2010 |
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Recurrence; Theophylline; Xanthines | 2010 |
[Prophylaxis and therapy of postdural puncture headache--a critical evaluation of treatment options].
Topics: Adrenocorticotropic Hormone; Adult; Analgesics; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Female; Humans; Injections, Spinal; Morphine; Post-Dural Puncture Headache; Pregnancy; Serotonin Antagonists; Theophylline; Vasodilator Agents | 2011 |
Drug therapy for treating post-dural puncture headache.
Topics: Adrenocorticotropic Hormone; Amines; Analgesics; Caffeine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Male; Pain Measurement; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture; Sumatriptan; Theophylline; Treatment Outcome | 2011 |
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
Topics: Adolescent; Adult; Caffeine; Clozapine; Computer Simulation; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Humans; Liver; Male; Middle Aged; Models, Biological; Serotonin 5-HT2 Receptor Agonists; Smoking; Theophylline; Young Adult | 2012 |
Measurement of CYP1A2 activity: a focus on caffeine as a probe.
Topics: Animals; Breath Tests; Caffeine; Cytochrome P-450 CYP1A2; Humans; Saliva; Theobromine; Theophylline | 2012 |
[Post-dural puncture headache].
Topics: Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Humans; Morphine; Needles; Post-Dural Puncture Headache; Theophylline; Vasodilator Agents | 2013 |
Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Citrates; Drug Monitoring; Humans; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Theophylline | 2014 |
Safety considerations for patients with epilepsy taking antiepileptic drugs alongside caffeine or other methylxanthine derivatives.
Topics: Aminophylline; Animals; Anticonvulsants; Caffeine; Coffee; Drug Interactions; Epilepsy; Humans; Theophylline; Xanthines | 2014 |
Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners.
Topics: Alkaloids; Anti-Inflammatory Agents; Antioxidants; Athletes; Beverages; Caffeine; Catechols; Diet; Dietary Supplements; Ephedrine; Exercise; Fatty Alcohols; Food; Food Analysis; Humans; Immune System; Immunologic Factors; Molecular Structure; Phytotherapy; Plants, Medicinal; Theophylline | 2014 |
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobromine; Theophylline; Uric Acid | 2015 |
Drug therapy for treating post-dural puncture headache.
Topics: Adrenocorticotropic Hormone; Adult; Amines; Analgesics; Blood Patch, Epidural; Caffeine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Male; Middle Aged; Pain Measurement; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture; Sumatriptan; Theophylline; Treatment Outcome | 2015 |
The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.
Topics: Adolescent; Apnea; Asthma; Bronchodilator Agents; Caffeine; Child; Child, Preschool; Cough; Humans; Infant; Infant, Newborn; Infant, Premature; Phosphodiesterase Inhibitors; Theobromine; Theophylline; Xanthines | 2016 |
Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.
Topics: Animals; Cacao; Caffeine; Humans; Molecular Structure; Phytochemicals; Secondary Metabolism; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 2016 |
Doxapram Treatment for Apnea of Prematurity: A Systematic Review.
Topics: Apnea; Caffeine; Doxapram; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Respiratory System Agents; Theophylline | 2017 |
Health benefits of methylxanthines in neurodegenerative diseases.
Topics: Animals; Cacao; Caffeine; Coffee; Disease Models, Animal; Humans; Ilex paraguariensis; Meta-Analysis as Topic; Neurodegenerative Diseases; Plant Extracts; Theobromine; Theophylline; Xanthines | 2017 |
Second-harmonic generation-based methods to detect and characterize ligand-induced RNA conformational changes.
Topics: Caffeine; Drug Discovery; High-Throughput Screening Assays; Humans; Ligands; Nucleic Acid Conformation; RNA; Theophylline | 2019 |
Systematic analysis to assess the scientific validity of the international residue limits for caffeine and theophylline in horse-racing.
Topics: Animals; Caffeine; Doping in Sports; Drug Residues; Horses; Internationality; Reproducibility of Results; Theophylline | 2019 |
Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit: A Systematic Overview of Meta-Analyses.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Randomized Controlled Trials as Topic; Theophylline; Treatment Outcome | 2020 |
Methylxanthines and Neurodegenerative Diseases: An Update.
Topics: Alzheimer Disease; Animals; Caffeine; Coffee; Humans; Multiple Sclerosis; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Theobromine; Theophylline; Xanthines | 2021 |
Advances in Neonatal Acute Kidney Injury.
Topics: Acute Kidney Injury; Biomarkers; Caffeine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Premature; Kidney; Lipocalin-2; Multicenter Studies as Topic; Oxygen Consumption; Renal Replacement Therapy; Research; Risk Factors; Theophylline; Water-Electrolyte Balance | 2021 |
Anesthetics and Cell-Cell Communication: Potential Ca
Topics: Anesthetics; Anesthetics, Inhalation; Caffeine; Calcium; Calmodulin; Cell Communication; Connexins; Gap Junctions; Halothane; Heptanol; Ion Channels; Isoflurane; Theophylline | 2022 |
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid | 2023 |
Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants.
Topics: Aminophylline; Apnea; Birth Weight; Bronchopulmonary Dysplasia; Caffeine; Hearing Loss; Humans; Infant, Extremely Premature; Infant, Newborn; Randomized Controlled Trials as Topic; Theophylline | 2023 |
72 trial(s) available for caffeine and theophylline
| Article | Year |
|---|---|
Caffeine or theophylline for neonatal apnoea?
Topics: Apnea; Caffeine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Infant, Premature; Theophylline; Time Factors; Treatment Outcome | 1992 |
A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects.
Topics: Aged; Caffeine; Central Nervous System; Double-Blind Method; Humans; Middle Aged; Neuropsychological Tests; Psychomotor Performance; Reference Values; Theophylline | 1991 |
The influence of caffeine on the steady-state pharmacokinetics of theophylline.
Topics: Administration, Oral; Adult; Caffeine; Drug Administration Schedule; Humans; Infusions, Intravenous; Male; Theophylline | 1991 |
Caffeine consumption decreases the response to bronchoprovocation challenge with dry gas hyperventilation.
Topics: Adolescent; Adult; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Caffeine; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Humidity; Hyperventilation; Male; Prospective Studies; Theophylline; Vital Capacity | 1991 |
Lack of interaction between lomefloxacin and caffeine in normal volunteers.
Topics: 4-Quinolones; Adult; Anti-Infective Agents; Caffeine; Double-Blind Method; Drug Interactions; Fluoroquinolones; Half-Life; Humans; Male; Quinolones; Theophylline | 1991 |
Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration.
Topics: 4-Quinolones; Adult; Anti-Infective Agents; Caffeine; Fluoroquinolones; Humans; Male; Quinolones; Theophylline | 1991 |
Dose-dependency of caffeine metabolism with repeated dosing.
Topics: Adult; Caffeine; Cardiovascular Diseases; Coffee; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Random Allocation; Risk Factors; Theobromine; Theophylline | 1990 |
Theophylline disturbs sleep mainly in caffeine-sensitive persons.
Topics: Caffeine; Double-Blind Method; Humans; Male; Sleep Wake Disorders; Surveys and Questionnaires; Theophylline | 1989 |
Comparative evaluation of caffeine and theophylline for weaning premature infants from the ventilator.
Topics: Caffeine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Infant, Premature; Male; Random Allocation; Respiration; Stimulation, Chemical; Theophylline; Time Factors; Ventilator Weaning | 1989 |
The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants.
Topics: Administration, Oral; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant, Newborn; Infant, Premature; Male; Random Allocation; Theophylline | 1989 |
Pharmacologic provocation and dexamethasone suppression test sensitivity.
Topics: Caffeine; Depressive Disorder; Dexamethasone; Electroconvulsive Therapy; Humans; Hydrocortisone; Lorazepam; Prognosis; Randomized Controlled Trials as Topic; Theophylline | 1989 |
4-quinolones inhibit biotransformation of caffeine.
Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline | 1988 |
[Gyrase inhibitors can delay caffeine elimination].
Topics: Caffeine; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Theophylline | 1986 |
A controlled trial using ephedrine in the treatment of obesity.
Topics: Caffeine; Clinical Trials as Topic; Drug Combinations; Ephedrine; Humans; Obesity; Theophylline | 1986 |
Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant.
Topics: Apnea; Caffeine; Double-Blind Method; Heart Rate; Humans; Infant, Newborn; Infant, Premature, Diseases; Natriuresis; Random Allocation; Respiration; Theophylline | 1987 |
The thermogenic properties of ephedrine/methylxanthine mixtures: human studies.
Topics: Adult; Basal Metabolism; Body Temperature Regulation; Caffeine; Calorimetry; Disease Susceptibility; Drug Combinations; Energy Metabolism; Ephedrine; Fasting; Female; Food; Humans; Male; Obesity; Theophylline; Xanthines | 1986 |
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromine; Theophylline | 1985 |
Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Tachycardia; Theophylline | 1985 |
[Clinical experiences with a vasoactive combination drug].
Topics: Caffeine; Cerebrovascular Disorders; Clinical Trials as Topic; Estradiol; Humans; Testosterone; Theophylline; Vasodilator Agents | 1965 |
Caffeine and theophylline counteract diazepam effects in man.
Topics: Adult; Caffeine; Clinical Trials as Topic; Cognition; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Antagonism; Female; Flicker Fusion; Humans; Male; Psychomotor Performance; Theophylline | 1983 |
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children].
Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines | 1984 |
Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates.
Topics: Apnea; Bradycardia; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline | 1995 |
Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.
Topics: Adult; Aged; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Oxidoreductases; Phenotype; Reference Values; Retrospective Studies; Saliva; Theophylline | 1994 |
Caffeine metabolism and epinephrine responses during exercise in users and nonusers.
Topics: Adult; Blood Glucose; Caffeine; Catecholamines; Epinephrine; Exercise; Fatty Acids, Nonesterified; Glycerol; Habituation, Psychophysiologic; Humans; Lactates; Lactic Acid; Male; Oxygen Consumption; Substance Withdrawal Syndrome; Theophylline | 1993 |
Sympathomimetic effects of paraxanthine and caffeine in humans.
Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Epinephrine; Fatty Acids; Female; Heart Rate; Humans; Male; Middle Aged; Norepinephrine; Reference Values; Theophylline | 1995 |
Methylxanthines increase renal calcium excretion in preterm infants.
Topics: Caffeine; Calcium; Humans; Infant, Newborn; Infant, Premature; Kidney; Theophylline | 1995 |
Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance.
Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Injections, Intravenous; Isotope Labeling; Male; Middle Aged; Oxidoreductases; Reference Values; Regression Analysis; Smoking; Theophylline | 1996 |
Comparative effects of theophylline and caffeine on respiratory function of prematurely born infants.
Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature, Diseases; Respiration; Respiratory Distress Syndrome, Newborn; Respiratory Function Tests; Theophylline; Time Factors | 1998 |
Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants.
Topics: Anemia; Apnea; Caffeine; Erythropoietin; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline | 1998 |
Psychomotor performance: investigating the dose-response relationship for caffeine and theophylline in elderly volunteers.
Topics: Aged; Aged, 80 and over; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychomotor Performance; Theophylline | 1998 |
Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance.
Topics: Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Interactions; Fluvoxamine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Theophylline | 1999 |
The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained?
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Humans; Male; Saliva; Specimen Handling; Theophylline | 1999 |
Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women.
Topics: Aged; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Estradiol; Estrogen Replacement Therapy; Female; Humans; Menopause; Middle Aged; Theophylline | 1999 |
Omeprazole weakly inhibits CYP1A2 activity in man.
Topics: Adult; Binding, Competitive; Biomarkers; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Omeprazole; Single-Blind Method; Theophylline | 1999 |
Effect of caffeine on clozapine pharmacokinetics in healthy volunteers.
Topics: Adult; Antipsychotic Agents; Area Under Curve; Biotransformation; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Clozapine; Cross-Over Studies; Humans; Male; Theophylline | 2000 |
Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.
Topics: Adolescent; Adult; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Data Interpretation, Statistical; Female; Humans; Male; Metabolic Clearance Rate; Phenotype; Polymorphism, Genetic; Sex Factors; Theophylline | 2000 |
Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Menstrual Cycle; Middle Aged; Pilot Projects; Saliva; Theophylline | 2000 |
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
Topics: Administration, Oral; Caffeine; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Female; Half-Life; Humans; Infant; Kwashiorkor; Malaria; Male; Metabolic Clearance Rate; Nigeria; Theophylline | 2000 |
The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Caffeine; Child; Cytochrome P-450 CYP1A2; Female; Humans; Malaria, Falciparum; Male; Metabolic Clearance Rate; Nigeria; Saliva; Theophylline | 2000 |
Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Blood Glucose; Caffeine; Central Nervous System Stimulants; Citric Acid; Cyclic AMP; Energy Metabolism; Epinephrine; Fatty Acids, Nonesterified; Glucose-6-Phosphatase; Glycerol; Glycogen; Humans; Lactic Acid; Male; Muscle, Skeletal; Norepinephrine; Oxygen Consumption; Physical Endurance; Theophylline; Vasodilator Agents; Xanthines | 2000 |
An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.
Topics: Adult; Anthropometry; Blood Pressure; Caffeine; Dietary Supplements; Double-Blind Method; Drug Combinations; Drugs, Chinese Herbal; Female; Heart Rate; Humans; Male; Middle Aged; Obesity; Theobromine; Theophylline; Triglycerides; Weight Loss | 2001 |
In vivo effect of clarithromycin on multiple cytochrome P450s.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Humans; Male; Theophylline; Tolbutamide | 2001 |
Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.
Topics: Caffeine; Double-Blind Method; Female; Gastric Emptying; Humans; Ilex paraguariensis; Male; Obesity; Phytotherapy; Plant Extracts; Plant Leaves; Seeds; Stomach; Theobromine; Theophylline; Time Factors; Turnera; Ultrasonography; Weight Loss | 2001 |
Drug interactions with clinafloxacin.
Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin | 2001 |
Urinary biomarkers for assessing dietary exposure to caffeine.
Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines | 2001 |
Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use.
Topics: Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Emotions; Ephedra; Ephedra sinica; Ephedrine; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Heart Rate; Humans; Male; Phenylpropanolamine; Pilot Projects; Reference Values; Theobromine; Theophylline | 2002 |
Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine.
Topics: Adult; Bicycling; Caffeine; Double-Blind Method; Drug Administration Schedule; Humans; Male; Osmolar Concentration; Physical Endurance; Theophylline | 2003 |
Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers.
Topics: Adult; Bronchodilator Agents; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Female; Humans; Isoflavones; Male; Single-Blind Method; Theophylline | 2003 |
Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio.
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Theophylline | 2003 |
Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Central Nervous System Stimulants; Energy Metabolism; Humans; Lipid Metabolism; Lipolysis; Male; Oxidation-Reduction; Propranolol; Theophylline | 2004 |
Salivary caffeine metabolic ratio in alcohol-dependent subjects.
Topics: Alcoholism; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Humans; Liver Diseases; Liver Function Tests; Male; Saliva; Smoking; Theophylline | 2004 |
Serum metabolite/caffeine ratios as a test for liver function.
Topics: Adult; Caffeine; Female; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Theobromine; Theophylline | 2004 |
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
Topics: Administration, Inhalation; Administration, Oral; Biological Availability; Caffeine; Central Nervous System Stimulants; Drug Combinations; Drug Interactions; Half-Life; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Narcotics; Population; Theobromine; Theophylline | 2005 |
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline | 2005 |
A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans.
Topics: Administration, Oral; Adult; Affect; Attention; Caffeine; Capsules; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memory; Psychotropic Drugs; Reference Values; Theobromine; Theophylline | 2007 |
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline | 2006 |
Urinary excretion of dietary contaminants in horses.
Topics: Animals; Atropine; Bufotenin; Caffeine; Cross-Over Studies; Doping in Sports; Dose-Response Relationship, Drug; Food Contamination; Horses; Morphine; N,N-Dimethyltryptamine; Physical Conditioning, Animal; Scopolamine; Theobromine; Theophylline | 2006 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline | 2008 |
Caffeine versus theophylline for apnea of prematurity: a randomised controlled trial.
Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Drug Therapy, Combination; Greece; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Secondary Prevention; Theophylline | 2009 |
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stability; Humans; Least-Squares Analysis; Male; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline; Young Adult | 2010 |
Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics.
Topics: Adult; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clinical Enzyme Tests; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Reference Values; Saliva; Theophylline; Young Adult | 2011 |
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
Topics: Adolescent; Adult; Caffeine; Clozapine; Computer Simulation; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Humans; Liver; Male; Middle Aged; Models, Biological; Serotonin 5-HT2 Receptor Agonists; Smoking; Theophylline; Young Adult | 2012 |
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult | 2012 |
Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects.
Topics: Adult; Bacillus; Blood Pressure; Caffeine; Cross-Over Studies; Dietary Supplements; Drug Contamination; Electrocardiography; Heart Rate; Humans; Male; Theophylline | 2013 |
Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial.
Topics: Adolescent; Adult; Biomarkers; Blood Pressure; Cacao; Caffeine; Candy; Catechin; Double-Blind Method; Endothelium; Energy Intake; Feasibility Studies; Female; Healthy Volunteers; Humans; Patient Compliance; Pilot Projects; Polyphenols; Pregnancy; Theobromine; Theophylline; Young Adult | 2013 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
The effect of a single dose of multivitamin and mineral combinations with and without guaraná on functional brain activity during a continuous performance task.
Topics: Adolescent; Adult; Attention; Brain; Caffeine; Calcium, Dietary; Cognition; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Evoked Potentials, Visual; Follow-Up Studies; Functional Neuroimaging; Humans; Magnesium; Neurons; Performance-Enhancing Substances; Theobromine; Theophylline; Vitamins; Young Adult; Zinc | 2017 |
The Effect of Caffeine Ingestion during Evening Exercise on Subsequent Sleep Quality in Females.
Topics: Adult; Caffeine; Contraceptives, Oral; Cross-Over Studies; Double-Blind Method; Exercise; Exercise Test; Female; Humans; Sleep; Theobromine; Theophylline; Young Adult | 2015 |
Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Pregnancy; Pregnancy Trimesters; Theobromine; Theophylline; Young Adult | 2016 |
Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring.
Topics: Animals; Animals, Newborn; Caffeine; Drug Monitoring; Glucose; Healthy Volunteers; Hydrogel, Polyethylene Glycol Dimethacrylate; Microinjections; Pharmaceutical Preparations; Rats; Reproducibility of Results; Sus scrofa; Theophylline | 2015 |
Establishing population distribution of drug-metabolizing enzyme activities for the use of salivary caffeine as a dynamic liver function marker in a Singaporean Chinese population.
Topics: Adult; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Liver; Male; Middle Aged; Saliva; Theophylline; Young Adult | 2016 |
A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects.
Topics: Adult; Anticonvulsants; Caffeine; Cannabidiol; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Humans; Male; Theophylline; Young Adult | 2021 |
1502 other study(ies) available for caffeine and theophylline
| Article | Year |
|---|---|
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
Topics: Acute Kidney Injury; Adenosine; Animals; Cations, Monovalent; Diuretics; Male; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sodium; Structure-Activity Relationship; Xanthines | 1992 |
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Guinea Pigs; Humans; Molecular Conformation; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Xanthines | 1992 |
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Corpus Striatum; Guinea Pigs; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Structure-Activity Relationship; Xanthines | 1992 |
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
Topics: Animals; Diuretics; Indicators and Reagents; Kidney; Kidney Function Tests; Kinetics; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1991 |
Imidazodiazepinediones: a new class of adenosine receptor antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Azepines; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Imidazoles; In Vitro Techniques; Molecular Conformation; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Structure-Activity Relationship | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines | 1989 |
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.
Topics: Animals; Brain; Cell Membrane; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1989 |
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
Topics: Adenosine; Animals; Cerebral Cortex; In Vitro Techniques; Rats; Receptors, Cell Surface; Receptors, Purinergic; Solubility; Structure-Activity Relationship | 1985 |
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
Topics: Animals; Caffeine; Cell Membrane; Cerebral Cortex; Indicators and Reagents; Mass Spectrometry; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthines | 1986 |
Mesoionic xanthine analogues: antagonists of adenosine receptors.
Topics: Adenosine; Animals; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Rats; Receptors, Cell Surface; Receptors, Purinergic; Spectrophotometry, Infrared; Structure-Activity Relationship; Xanthines | 1984 |
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines | 1994 |
8-Azaxanthine derivatives as antagonists of adenosine receptors.
Topics: Animals; Brain; Cattle; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines | 1994 |
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.
Topics: Animals; Brain; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Xanthines | 1994 |
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.
Topics: Adenosine; Amnesia; Animals; Avoidance Learning; Diuretics; Male; Mice; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptors, Purinergic; Scopolamine; Structure-Activity Relationship; Xanthines | 1993 |
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
Topics: Acylation; Alkylation; Animals; Brain; Caffeine; Cell Membrane; Cyclization; Molecular Structure; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Trifluoroacetic Acid; Xanthines | 1993 |
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.
Topics: Adenosine; Animals; Binding, Competitive; Brain; Caffeine; Molecular Structure; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theobromine; Xanthines | 1997 |
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.
Topics: Acridines; Alkaloids; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Artemia; Bacteria; Cladosporium; Drug Screening Assays, Antitumor; HeLa Cells; Humans; In Vitro Techniques; Insecticides; Microbial Sensitivity Tests; Neostriatum; Porifera; Rats; Receptors, GABA-A; Receptors, Purinergic P1 | 1998 |
Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues.
Topics: Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Cyclic ADP-Ribose; Drug Evaluation, Preclinical; In Vitro Techniques; Ovum; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Structure-Activity Relationship; Xanthines | 1999 |
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea.
Topics: Chromones; Flavonoids; Luteolin; Naphthalenes; Plants, Medicinal; Receptors, Purinergic P1; Spectrum Analysis | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines | 2002 |
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.
Topics: 3T3 Cells; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Electrophoresis, Capillary; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; In Vitro Techniques; Membranes; Mice; PC12 Cells; Purinergic P1 Receptor Antagonists; Purines; Purinones; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Solubility; Stereoisomerism; Structure-Activity Relationship; Water | 2002 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.
Topics: Estradiol; Female; Humans; In Vitro Techniques; Male; Metribolone; Pregnenediones; Prostate; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Thermodynamics; Uterus | 2005 |
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Topics: Chitinases; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Protein Binding; Xanthines | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Impaired mutagenic activities of MPDP(+) (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP(+) (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines.
Topics: 1-Methyl-4-phenylpyridinium; Caffeine; Calorimetry; Drug Interactions; Models, Molecular; Molecular Structure; Mutagens; Pentoxifylline; Pyridinium Compounds; Spectrophotometry, Atomic; Vibrio | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies.
Topics: | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Animals; Drug Design; Humans; Molecular Structure; Rats; Receptor, Adenosine A1; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2010 |
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.
Topics: Adenosine A2 Receptor Antagonists; Amino Acid Sequence; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Receptor, Adenosine A2B; Reproducibility of Results; Sequence Homology, Amino Acid | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.
Topics: Action Potentials; Animals; Behavior, Animal; Cells, Cultured; Convulsants; Crystallography, X-Ray; Excitatory Postsynaptic Potentials; Guanine; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neurons; Palau; Patch-Clamp Techniques; Porifera; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Synaptic Transmission | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Biophysical mapping of the adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Drug Design; Ligands; Models, Molecular; Mutation; Pyrimidines; Receptor, Adenosine A2A; Small Molecule Libraries; Triazines; Triazoles; Xanthines | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines--analysis with mathematical models.
Topics: Aminacrine; Animals; Caffeine; Cattle; DNA; Drug Antagonism; Epithelial Cells; Intercalating Agents; Kidney; Kinetics; Models, Chemical; Mutagens; Nitrogen Mustard Compounds; Pentoxifylline; Salmonella typhimurium; Theophylline; Thermodynamics | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines | 2013 |
Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
Topics: Algorithms; Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quantitative Structure-Activity Relationship | 2014 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoenzymes; Mice; Mice, Knockout; Models, Molecular; Molecular Structure; Retinal Dehydrogenase; Structure-Activity Relationship | 2015 |
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
Topics: Acetylcholinesterase; Animals; Benzofurans; Blood-Brain Barrier; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Drug Stability; Microsomes, Liver; Molecular Docking Simulation; Permeability; Rats; Structure-Activity Relationship; Torpedo | 2015 |
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.
Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Pyrimidinones; Receptor, Adenosine A2B; Structure-Activity Relationship | 2016 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.
Topics: | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2020 |
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphenyl Compounds; Butyrylcholinesterase; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuroprotective Agents; Picrates; Rats; Structure-Activity Relationship; Sulfonic Acids; Xanthones | 2021 |
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Topics: Binding Sites; Catalytic Domain; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Esterases; Humans; Molecular Dynamics Simulation; Small Molecule Libraries; Wnt Signaling Pathway | 2021 |
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines | 2021 |
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors | 2021 |
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments.
Topics: | 2022 |
[Level of nicotinamide coenzymes in the myocardium of rats during the effects of methylxanthines (theophylline, theobromine, caffeine) and catecholamines].
Topics: Animals; Caffeine; Epinephrine; Female; Heart; Isoproterenol; Male; Myocardium; NAD; NADP; Norepinephrine; Rats; Stimulation, Chemical; Theobromine; Theophylline | 1975 |
Practolol, caffeine and calcium in the regulation of mechanical activity of the cardiac ventricle in Myxine glutinosa (L.).
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Fishes; Hagfishes; Heart Ventricles; Hydroxydopamines; Myocardial Contraction; Phenoxybenzamine; Phentolamine; Practolol; Propranolol; Reserpine; Theophylline; Ventricular Function | 1975 |
Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists.
Topics: Action Potentials; Adenine Nucleotides; Adenosine; Animals; Blood Pressure; Caffeine; Cerebral Cortex; Dose-Response Relationship, Drug; Hexobendine; Male; Neurotransmitter Agents; Papaverine; Rats; Receptors, Drug; Structure-Activity Relationship; Theophylline | 1975 |
Cylic nucleotide phosphodiesterase in silkworm. Characterization of cyclic GMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bombyx; Caffeine; Chromatography, Gel; Cyclic AMP; Cyclic GMP; Cyclic IMP; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Molecular Weight; Nucleotides; Phosphoric Diester Hydrolases; Theophylline | 1975 |
Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Calcium; Cobalt; Cyclic AMP; Cyclic GMP; Depression, Chemical; Edetic Acid; Egtazic Acid; Hydrogen-Ion Concentration; Magnesium; Manganese; Neoplasm Metastasis; Nickel; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Theophylline; Zinc | 1976 |
Letter: Caffeine, theophylline and human sperm motility.
Topics: Caffeine; Cells, Cultured; Humans; Hydrogen-Ion Concentration; Male; Sperm Motility; Theophylline | 1976 |
Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat.
Topics: Amobarbital; Amphetamines; Anesthetics; Animals; Benzamides; Bucladesine; Caffeine; Central Nervous System Stimulants; Doxapram; Male; Pentylenetetrazole; Picrotoxin; Rats; Strychnine; Theophylline | 1976 |
Potentiation of dopaminergic transmission by phosphodiesterase inhibitors and cyclic nucleotides.
Topics: Action Potentials; Animals; Bucladesine; Caffeine; Cyclic AMP; Dopamine; In Vitro Techniques; Mollusca; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Prostaglandins E; Synaptic Transmission; Theophylline | 1976 |
Cyclic nucleotide phosphodiesterases of Hyalophora cecropia silkmoth fat body.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Bombyx; Caffeine; Chromatography, Gel; Cyclic AMP; Cyclic GMP; Edetic Acid; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Larva; Manganese; Phosphoric Diester Hydrolases; Theophylline | 1977 |
Caffeine-phenacetin interaction in the rat: effects on absorption, metabolism and locomotor activity.
Topics: Animals; Caffeine; Dextroamphetamine; Drug Interactions; Female; Intestinal Absorption; Motor Activity; Phenacetin; Rats; Theobromine; Theophylline; Time Factors | 1977 |
Interpretation of dissolution rate data from in vitro testing of compressed tablets.
Topics: Aspirin; Caffeine; Chemistry, Pharmaceutical; Hardness; Kinetics; Models, Chemical; Solubility; Surface Properties; Tablets; Theophylline; Time Factors | 1977 |
Association of increased pHi with calcium ion release in skeletal muscle.
Topics: Animals; Anura; Caffeine; Calcium; Dantrolene; Dimethadione; Extracellular Space; Hydrogen-Ion Concentration; Insulin; Muscles; Procaine; Quinine; Rana pipiens; Sarcoplasmic Reticulum; Theophylline | 1978 |
Clear, defined medium for the sporulation of Clostridium perfringens.
Topics: Caffeine; Clostridium perfringens; Culture Media; Hydrogen-Ion Concentration; Spores, Bacterial; Theophylline | 1978 |
Influence of methyl xanthine treatment on calcitonin effect.
Topics: Androgens; Animals; Caffeine; Calcitonin; Calcium; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Time Factors; Xanthines | 1978 |
Intravenous cimetidine and methylxanthines stimulated gastric acid secretion in man.
Topics: Adult; Caffeine; Cimetidine; Female; Gastric Juice; Guanidines; Histamine H2 Antagonists; Humans; Male; Stimulation, Chemical; Theophylline | 1979 |
Enhancement effect of methylxanthines on the intestinal absorption of poorly absorbable dyes from the rat small intestine.
Topics: Animals; Bromphenol Blue; Caffeine; Coloring Agents; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Phenolsulfonphthalein; Rats; Salicylates; Theophylline; Xanthines | 1979 |
Chromatography of xanthines on ion-exchange resins.
Topics: Caffeine; Cation Exchange Resins; Chromatography, Ion Exchange; Coffee; Humans; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Theophylline; Xanthines | 1979 |
Cyclic nucleotide phosphodiesterase activity of human normal and carcinomatous lung tissue.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Caffeine; Carcinoma, Squamous Cell; Cyclic AMP; Cyclic GMP; Female; Humans; Lung; Lung Neoplasms; Middle Aged; Phosphoric Diester Hydrolases; Theophylline | 1976 |
Biotransformation of theophylline to caffeine in premature newborn.
Topics: Administration, Oral; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline | 1978 |
Methylation of theophylline to caffeine in premature infants.
Topics: Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Methylation; Theophylline; Xanthines | 1979 |
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles | 1979 |
Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Protein Denaturation; Theophylline; Time Factors; Xanthines | 1979 |
The inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Aminophylline; Animals; Caffeine; Cerebral Cortex; Female; Histocytochemistry; Male; Rats; Synaptosomes; Theophylline; Xanthines | 1979 |
Effect of cAMP on acrosome reaction and fertilization.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Bucladesine; Caffeine; Cricetinae; Cyclic AMP; Female; Fertilization; Guinea Pigs; Imidazoles; Male; Ovum; Phosphodiesterase Inhibitors; Sperm Motility; Spermatozoa; Theophylline | 1979 |
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: relationship of enzyme activity to cyclic AMP concentrations.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Induction; HeLa Cells; Humans; Hydrocortisone; Idoxuridine; Theophylline; Xanthines | 1979 |
Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cell Survival; Jejunum; Male; Mice; Radiation-Protective Agents; Reserpine; Theophylline | 1979 |
Inhibition of RNA-dependent DNA polymerase activity of oncornaviruses by caffeine.
Topics: Aminophylline; Avian Leukosis Virus; Avian Myeloblastosis Virus; Caffeine; Kinetics; Reverse Transcriptase Inhibitors; Templates, Genetic; Theophylline | 1979 |
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Brain; Caffeine; Cerebral Cortex; Male; Neural Inhibition; Neurons; Rats; Synapses; Synaptic Transmission; Theophylline | 1979 |
Calcium and cyclic nucleotide interaction in secretion of amylase from rat pancreas in vitro.
Topics: Amylases; Animals; Bucladesine; Caffeine; Calcimycin; Calcium; Cholecystokinin; Cholera Toxin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Pancreas; Rats; Secretory Rate; Theophylline | 1979 |
The change of erythrocyte shape following action of different substances altering mg++-dependent ATPase activity (actomyosin-like protein).
Topics: Adenosine Triphosphatases; Aspartic Acid; Atropine; Barbiturates; Caffeine; Dose-Response Relationship, Drug; Ephedrine; Erythrocytes; Glutamates; Humans; Magnesium; Physostigmine; Theophylline | 1977 |
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline | 1977 |
Human placental cAMP phosphodiesterase activity kinetic properties and sensitivity to some drugs and hormones.
Topics: Caffeine; Cyclic AMP; Epinephrine; Estradiol; Female; Flufenamic Acid; Hormones; Humans; Imidazoles; Indomethacin; Insulin; Kinetics; Magnesium; Norepinephrine; Pharmacology; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Progesterone; Prostaglandins; Theophylline | 1975 |
Methylxanthine induced small intestinal secretion.
Topics: Animals; Animals, Newborn; Caffeine; Coffee; Cyclic AMP; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Jejunum; Male; Phosphodiesterase Inhibitors; Rats; Stimulation, Chemical; Theophylline; Time Factors | 1975 |
Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Male; Morphine; Naloxone; Phosphodiesterase Inhibitors; Prostaglandins; Rats; Structure-Activity Relationship; Substance Withdrawal Syndrome; Theophylline; Time Factors; Xanthines | 1975 |
Enhancement of SV40 transformation by treatment of C3H2K cells with UV light and caffeine. I. Combined effect of UV light and caffeine.
Topics: Animals; Bucladesine; Caffeine; Cell Line; Cell Transformation, Neoplastic; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Kidney; Mice; Mice, Inbred Strains; Radiation Effects; Simian virus 40; Theophylline; Ultraviolet Rays | 1975 |
Bronchodilator drug efficacy via cyclic AMP.
Topics: Animals; Bronchodilator Agents; Caffeine; Cyclic AMP; Ephedrine; Epinephrine; Isoproterenol; Lung; Norepinephrine; Phentolamine; Propranolol; Rats; Theophylline | 1975 |
Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature.
Topics: Adrenal Glands; Adrenalectomy; Aminophylline; Animals; Caffeine; Cell Nucleus; Cyclic AMP; Cytosol; Dexamethasone; Kinetics; Liver; Male; Rats; Receptors, Cell Surface; Temperature; Theophylline | 1975 |
Actions of various methylxanthines and papaverine on the synthesis of corticosterone in vitro.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Bucladesine; Caffeine; Corticosterone; Depression, Chemical; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Theobromine; Theophylline; Time Factors | 1975 |
Calcium distribution in islets of Langerhans: a study of calcium concentrations and of calcium accumulation in B cell organelles.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biological Transport, Active; Bucladesine; Caffeine; Calcium; Cell Nucleus; Cyclic AMP; Cyclic GMP; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Female; Islets of Langerhans; Mitochondria; Rats; Subcellular Fractions; Theophylline; Xanthines | 1975 |
Circadian periodicity a neurospora: alteration by inhibitors of cyclic AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Circadian Rhythm; Cyclic AMP; Dose-Response Relationship, Drug; Mutation; Neurospora crassa; Phosphodiesterase Inhibitors; Theophylline | 1975 |
Comparative studies on sporulation-promotive actions on cyclic AMP, theophylline and caffeine in Saccharomyces cerevisiae.
Topics: Acetates; Caffeine; Cyclic AMP; DNA; Fungal Proteins; Glucose; RNA; Saccharomyces cerevisiae; Spores, Fungal; Theophylline | 1975 |
Induction of thymidylate synthetase activity in Tetrahymena by cyclic guanosine monophosphate.
Topics: Animals; Bucladesine; Caffeine; Cell Division; Culture Media; Cyclic GMP; Enzyme Induction; Methyltransferases; Tetrahymena pyriformis; Theophylline; Thymidylate Synthase | 1975 |
Effect of methylxanthines on alloxan inhibition of insulin release.
Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Xanthines | 1975 |
Specific thin-layer chromatographic method for the determination of theophylline in plasma in the presence of some other drugs.
Topics: Absorption; Caffeine; Chromatography, Thin Layer; Densitometry; Gels; Microchemistry; Silicon Dioxide; Spectrum Analysis; Theophylline | 1975 |
Inhibition of 5'-nucleotidase in rat brain by methylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Caffeine; Nucleotidases; Rats; Theobromine; Theophylline; Xanthines | 1975 |
Studies on myoinositol. Effects of caffeine and theophylline on incorporation of myoinositol into phosphatidylinositol in rat liver homogenate.
Topics: Animals; Caffeine; Cyclic AMP; In Vitro Techniques; Inositol; Liver; Phosphatidylinositols; Rats; Stimulation, Chemical; Theophylline | 1975 |
Cyclic AMP phosphodiesterase activity in fetal and adult muscle of the rhesus monkey.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Female; Kinetics; Macaca; Macaca mulatta; Male; Muscles; Phosphoric Diester Hydrolases; Pregnancy; Theophylline; Xanthines | 1976 |
[The stimulating effect of cyclic AMP, glucagon and insulin on guanidine acetate-N-methyltransferase activity in rat liver and pancreas].
Topics: Animals; Bucladesine; Caffeine; Cyclic AMP; Cycloheximide; Glucagon; Insulin; Liver; Magnesium; Methyltransferases; Oligomycins; Pancreas; Rats; Theophylline | 1976 |
Ammonium sulfate activation of phosphodiesterase in homogenates of larvae of the european corn borer.
Topics: Ammonium Sulfate; Animals; Astacoidea; Caffeine; Cattle; Enzyme Activation; Kidney; Larva; Lepidoptera; Liver; Moths; Osmolar Concentration; Phosphoric Diester Hydrolases; Rats; Sodium Chloride; Species Specificity; Theophylline | 1976 |
Poly(adenosine diphosphate ribose) polymerase activity and nicotinamide adenine dinucleotide in differentiating cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Nucleus; Dactinomycin; DNA; DNA Nucleotidyltransferases; Heart; Isoproterenol; Myocardium; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Proteins; Rats; Theophylline; Thymidine; Xanthines | 1976 |
A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens.
Topics: Blood Platelets; Caffeine; Cell Membrane; Cyclic AMP; Cytotoxicity Tests, Immunologic; Edetic Acid; Histocompatibility Antigens; HLA Antigens; Humans; Methods; Prostaglandins E; Solubility; Theophylline | 1976 |
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Drug Synergism; Epinephrine; Female; Haplorhini; Indomethacin; Macaca mulatta; Myometrium; Phosphoric Diester Hydrolases; Pregnancy; Prostaglandins E; Theophylline; Uterine Contraction; Uterus | 1976 |
Caffeine, cyclic AMP and postreplication repair of mammalian cell DNA.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Caffeine; Cell Line; Cyclic AMP; DNA Repair; DNA Replication; Drug Resistance; Theophylline | 1976 |
Partial purification of adenosine 3',5'-cyclic monophosphate phosphodiesterases from rat pancreas in the presence of excess protease inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cyclic GMP; Cyclic IMP; Isoenzymes; Kinetics; Male; Pancreas; Phosphoric Diester Hydrolases; Protease Inhibitors; Rats; Theophylline | 1976 |
Action of insulin and cell calcium: effect of ionophore A23187.
Topics: Animals; Anti-Bacterial Agents; Bucladesine; Caffeine; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Insulin; Membrane Potentials; Methylglucosides; Muscle Contraction; Muscles; Rats; Theophylline | 1976 |
Timing of mitosis in Physarum polycephalum: effects of agents affecting cyclic AMP concentrations.
Topics: Bucladesine; Caffeine; Culture Media; Cyclic AMP; Mitosis; Myxomycetes; Physarum; Theophylline; Time Factors | 1977 |
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation.
Topics: Angiotensin II; Animals; Caffeine; Drug Synergism; Female; Guinea Pigs; Ileum; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins E; Rats; Theophylline; Uterus; Xanthines | 1977 |
Characterization of sea urchin sperm adenylate cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Chromatography, Gel; Creatine Kinase; Cyclic AMP; Detergents; Hot Temperature; Kinetics; Magnesium; Male; Manganese; Phosphocreatine; Phosphoric Monoester Hydrolases; Sea Urchins; Solubility; Spermatozoa; Theophylline; Xanthines | 1977 |
Interaction of cyclic AMP and alloxan on insulin secretion in isolated rat islets perifused in vitro.
Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide | 1977 |
Adenosine-sensitive adenylate cyclase in rat striatal homogenates.
Topics: Adenosine; Adenosine Deaminase; Adenylyl Cyclases; Animals; Caffeine; Corpus Striatum; Cyclic AMP; Kinetics; Male; Rats; Structure-Activity Relationship; Theophylline; Xanthines | 1977 |
Effects of ACTH, adenyl compounds, and methylxanthines on goldfish erythrophores in culture.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adrenocorticotropic Hormone; Animals; Bucladesine; Caffeine; Cells, Cultured; Chromatophores; Cyclic AMP; Cytoplasmic Granules; Dose-Response Relationship, Drug; Goldfish; Kinetics; Microscopy, Phase-Contrast; Pigments, Biological; Theophylline; Xanthines | 1977 |
The interaction of 4-alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes with cyclic adenosine 3',5'-monophosphate phosphodiesterase, and with cyclic adenosine 3',5'-monophosphate binding proteins.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Caffeine; Carrier Proteins; Cerebral Cortex; Cyclic AMP; In Vitro Techniques; Kinetics; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Protein Binding; Sheep; Theophylline | 1977 |
Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors.
Topics: Adenosine; Blood Platelets; Caffeine; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Depression, Chemical; Dipyridamole; Humans; In Vitro Techniques; Kinetics; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Platelet Aggregation; Theophylline | 1977 |
Properties of human erythrocyte phosphatidylinositol kinase and inhibition by adenosine, ADP and related compounds.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Caffeine; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotides; Humans; Kinetics; Mercaptoethanol; Phosphatidylinositols; Phosphotransferases; Polyethylene Glycols; Theophylline | 1977 |
Effect of cyclic-AMP and other compounds on electrical activity of neurohaemal tissue in Carausius.
Topics: Action Potentials; Adenosine; Animals; Bucladesine; Caffeine; Cyclic AMP; Histamine; Insecta; Nervous System; Norepinephrine; Theophylline | 1977 |
Biochemical studies of taste sensation: II. Labelling of cyclic AMP of bovine taste papillae in response to sweet and bitter stimuli.
Topics: Adenine; Animals; Caffeine; Cattle; Cyclic AMP; Epinephrine; Lactose; Quinine; Sucrose; Taste; Taste Buds; Theophylline | 1976 |
Responses of proliferating cells to methylxanthines. Reversal of effect by colchicine.
Topics: Aminophylline; Bucladesine; Caffeine; Cell Division; Cell Nucleus; Colchicine; Mitotic Index; Plant Cells; Theobromine; Theophylline; Xanthines | 1977 |
The effects of methylxanthines on catecholamine-stimulated and normal chick embryos.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Abnormalities, Drug-Induced; Animals; Aortic Aneurysm; Aortic Arch Syndromes; Caffeine; Catecholamines; Chick Embryo; Drug Synergism; Epinephrine; Heart Defects, Congenital; Norepinephrine; Theophylline; Xanthines | 1977 |
Evidence for the specific involvement of cyclic AMP in the olfactory transduction mechanism.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anura; Caffeine; Cyclic AMP; Electrophysiology; Etazolate; Odorants; Olfactory Mucosa; Phosphodiesterase Inhibitors; Rana temporaria; Smell; Theophylline | 1977 |
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; Myometrium; Papaverine; Placenta; Pregnancy; Pregnancy Trimester, Third; Theophylline; Uterus | 1977 |
Effect of phosphodiesterase inhibitors and dBcAMP on the inotropic and relaxing actions of histamine in cardiac muscle.
Topics: Animals; Bucladesine; Caffeine; Drug Interactions; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Theophylline | 1977 |
Increased spore yields of Clostridium perfringens in the presence of methylxanthines.
Topics: Caffeine; Clostridium perfringens; Dextrins; Raffinose; Species Specificity; Spores, Bacterial; Theophylline; Xanthines | 1977 |
Changes in cyclic AMP levels in the amphibian ovarian follicle following progesterone induction of meiotic maturation. Effect of phosphodiesterase inhibitors and exogenous calcium on germinal vesicle breakdown.
Topics: Animals; Anura; Bucladesine; Caffeine; Calcium; Cyclic AMP; Female; Fertilization; Leucine; Meiosis; Ovarian Follicle; Phosphodiesterase Inhibitors; Progesterone; Rana pipiens; Theobromine; Theophylline | 1977 |
Agar plate screening procedure for cyclic adenosine 3',5'-monophosphate and inhibitors of cyclic nucleotide phosphodiesterase.
Topics: Adenylyl Cyclases; Agar; Bacteriological Techniques; Caffeine; Cyclic AMP; Escherichia coli; Fermentation; Galactose; Mutation; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Theophylline | 1977 |
Effect of methylxanthines on binding of the glucocorticoid receptor to DNA-cellulose and nuclei.
Topics: Adrenalectomy; Aminophylline; Animals; Caffeine; Cell Nucleus; Cyclic AMP; Cytosol; Dexamethasone; DNA; Kinetics; Liver; Male; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Theophylline; Xanthines | 1978 |
The actions of adenosine and various nucleosides and nucleotides on the isolated toad spinal cord.
Topics: Animals; Anura; Caffeine; Electric Stimulation; In Vitro Techniques; Magnesium; Nucleosides; Nucleotides; Purine Nucleosides; Purine Nucleotides; Purines; Pyrimidines; Spinal Cord; Synaptic Transmission; Theophylline | 1978 |
Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine.
Topics: Animals; Caffeine; Dogs; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Phosphoric Diester Hydrolases; Theophylline; Trachea; Uric Acid; Xanthines | 1978 |
Ultraviolet light induction of skin carcinoma in the mouse; influence of cAMP modifying agents.
Topics: Animals; Caffeine; Cyclic AMP; DNA Repair; Female; Mice; Neoplasms, Radiation-Induced; Phosphodiesterase Inhibitors; Skin; Skin Neoplasms; Theophylline; Ultraviolet Rays | 1978 |
[Effect of ionizing radiation on cerebral phosphodiesterase].
Topics: Animals; Brain; Caffeine; Enzyme Activation; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Theophylline; Thiopental; Time Factors; X-Rays | 1978 |
Effect of cyclic AMP on transformation and proliferation of leishmania cells.
Topics: Bucladesine; Caffeine; Cyclic AMP; Humans; Leishmania; Morphogenesis; Papaverine; Theophylline | 1978 |
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans; Male; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Xanthines | 1979 |
Regulation of lipogenesis in adipocytes. Independent effects of thyroid hormones, cyclic AMP and insulin on the uptake of deoxy-D-glucose.
Topics: Adipose Tissue; Animals; Biological Transport; Bucladesine; Caffeine; Cyclic AMP; Deoxy Sugars; Deoxyglucose; Female; Insulin; Rats; Theophylline; Thyroidectomy | 1979 |
Caffeine: its action on purine metabolizing enzymes.
Topics: Adenine; Aminohydrolases; Animals; Caffeine; Crithidia; Cyclic AMP; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Leukocytes; N-Glycosyl Hydrolases; Pentosyltransferases; Purines; Theophylline | 1979 |
Induction of alkaline phosphatase activity in HeLa cells by sodium butyrate.
Topics: Alkaline Phosphatase; Butyrates; Caffeine; Cyclic AMP; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Idoxuridine; Theophylline | 1979 |
Cyclic 3',5'-adenosine monophosphate phosphodiesterase (cAMP PDE) and cyclic 3',5'-guanosine monophosphate phosphodiesterase (cGMP PDE) in microvessels isolated from bovine cortex.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Calcium; Cattle; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Imidazoles; Magnesium; Microcirculation; Theobromine; Theophylline | 1979 |
A characteristic of the rate response which is common to several compounds that stimulate the heart.
Topics: Amitriptyline; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Heart Rate; Heterocyclic Compounds; Histamine; Male; Neurotransmitter Agents; Norepinephrine; Rabbits; Stimulation, Chemical; Theophylline | 1975 |
Amphibian pancreas function in long-term organ culture: control of insulin release.
Topics: Alloxan; Amphibians; Animals; Aprotinin; Caffeine; Calcium; Culture Media; Epinephrine; Glucagon; Insulin; Insulin Secretion; Lasalocid; Organ Culture Techniques; Pancreas; Radioimmunoassay; Theophylline; Time Factors | 1977 |
Comparative studies of the effects of drugs on X-ray-induced G2 delay.
Topics: Benzimidazoles; Caffeine; Cell Cycle; Cells, Cultured; Dactinomycin; Deoxyadenosines; Dimethyl Sulfoxide; Lucanthone; Mitosis; RNA; Sulfhydryl Compounds; Theophylline; Time Factors; X-Rays | 1978 |
Effect of methylxanthines and elevated external potassium on high energy phosphate content in frog skeletal muscle.
Topics: Animals; Anura; Caffeine; Calcium; Energy Metabolism; In Vitro Techniques; Muscles; Phosphates; Potassium; Rana pipiens; Sodium; Theophylline; Time Factors; Xanthines | 1978 |
Use of saliva in therapeutic drug monitoring.
Topics: Antipyrine; Caffeine; Ethosuximide; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Primidone; Saliva; Theophylline | 1977 |
Effects of methylxanthine drugs on pyrogen-induced hyperthermia.
Topics: Animals; Caffeine; Female; Fever; Male; Pyrogens; Rabbits; Shigella dysenteriae; Theophylline; Time Factors; Xanthines | 1977 |
Characterization of the uptake of the methylxanthines theophylline and caffeine in isolated pancreatic islets and their effect on D-glucose transport.
Topics: Animals; Biological Transport, Active; Caffeine; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Rats; Theophylline | 1977 |
Comparison of homogeneous enzyme immunoassay and high-pressure liquid chromatography for the determination of theophylline concentration in serum.
Topics: Caffeine; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Theobromine; Theophylline | 1978 |
Studies on the site of interaction for ninhydrin, alloxan, and D-glucose in insulin secretion by isolated islets in vitro.
Topics: Alloxan; Animals; Biological Transport; Caffeine; Cytochalasin B; Glucose; In Vitro Techniques; Indenes; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Ninhydrin; Rats; Theophylline | 1979 |
[Stimulation of the synthesis and non-competitive inhibition of alkaline phosphatase by theophylline in normal hamster fibroblasts and absence of response in transformed fibroblasts].
Topics: Alkaline Phosphatase; Animals; Caffeine; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Theophylline | 1977 |
Plasma xanthine levels in low birthweight infants treated or not treated with theophylline.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Milk, Human; Theophylline; Xanthines | 1979 |
Effect of calcium on strophanthidin-induced electrical and mechanical toxicity in cardiac Purkinje fibers.
Topics: Animals; Caffeine; Calcium; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Male; Membrane Potentials; Myocardial Contraction; Purkinje Fibers; Strophanthidin; Theophylline | 1979 |
Interference of theophylline and caffeine in the gas-chromatographic estimation of phenobarbital.
Topics: Caffeine; Chromatography, Gas; Humans; Phenobarbital; Theophylline | 1979 |
Metabolism of theophylline to caffeine in premature newborn infants.
Topics: Adult; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline | 1979 |
Interconversion of theophylline and caffeine in newborn infants.
Topics: Age Factors; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theobromine; Theophylline; Xanthines | 1979 |
Caffeine, a metabolite of theophylline during the treatment of apnea in the premature infant.
Topics: Apnea; Caffeine; Half-Life; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline | 1979 |
Effects of caffeine and D2O on persistence and de novo generation of intrinsic oscillatory contraction automaticity in Physarum.
Topics: Biological Transport, Active; Caffeine; Cell Membrane; Deuterium; Dose-Response Relationship, Drug; Movement; Physarum; Theophylline | 1979 |
Caffeine intake and potential effect on health of a segment of northern Canadian indigenous people.
Topics: Adult; Aged; Caffeine; Canada; Carbohydrate Metabolism; Coffee; Diet; Drug Utilization; Female; Health; Humans; Indians, North American; Male; Middle Aged; Tea; Theophylline | 1979 |
Reduction of cholesterol synthesis by methylxanthines in cultured glial cells.
Topics: Aminophylline; Caffeine; Cells, Cultured; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Nerve Tissue Proteins; Neuroglia; Theophylline; Xanthines | 1979 |
Theophylline acute poisoning in a child: evidence for biotransformation of theophylline into caffeine.
Topics: Biotransformation; Caffeine; Female; Humans; Infant; Theophylline | 1979 |
[Contribution to the study of paracetamol-theophylline and paracetamol-caffeine associations (author's transl)].
Topics: Acetaminophen; Caffeine; Chemical Phenomena; Chemistry; Chemistry, Physical; Theophylline | 1979 |
The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Caffeine; DNA; Hypoxanthines; In Vitro Techniques; Mice; Microsomes, Liver; Stimulation, Chemical; Theobromine; Theophylline; Uric Acid | 1979 |
Differential effects of cytochalasin B and caffeine on control of DNA synthesis in normal and transformed cells.
Topics: Animals; Caffeine; Cell Cycle; Cell Nucleus; Cell Transformation, Viral; Cytochalasin B; DNA; Fibroblasts; Humans; Mice; Papaverine; Theophylline | 1979 |
Metabolism of theophylline to caffeine in human fetal liver.
Topics: Apnea; Biotransformation; Caffeine; Cells, Cultured; Gestational Age; Humans; Infant, Newborn; Liver; Methylation; Theophylline | 1979 |
[Influence of glucagon, caffeine and theophylline on the active monosaccharide transport across the human spermatozoa cell membrane (author's transl)].
Topics: Biological Transport, Active; Caffeine; Cell Membrane Permeability; Fructose; Glucagon; Glucose; Humans; In Vitro Techniques; Male; Monosaccharides; Spermatozoa; Theophylline | 1979 |
Simultaneous and specific determination of proxyphylline, theophylline and other xanthine derivatives in serum by high pressure liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines | 1978 |
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.
Topics: Acetylcholine; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Morphine; Rats; Theophylline; Xanthines | 1978 |
Micro-method for the determination of caffeine and theophylline allowing direct application of biological fluids to thin-layer chromatography plates.
Topics: Apnea; Caffeine; Child; Child, Preschool; Chromatography, Thin Layer; Female; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Male; Microchemistry; Saliva; Theophylline | 1978 |
Induction of alkaline phosphatase activity in HeLa cells by choline chloride.
Topics: Alkaline Phosphatase; Caffeine; Cell Count; Choline; HeLa Cells; Hot Temperature; Idoxuridine; Phosphorylcholine; Sodium Chloride; Theophylline | 1978 |
Interactions of caffeine and theophylline with p-cresol: UV studies.
Topics: Caffeine; Chemical Phenomena; Chemistry; Cresols; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics | 1978 |
[Caffeine-11C, ephedrine-11C and methylephedrine-11C: Synthesis and distribution in mice (author's transl)].
Topics: Animals; Caffeine; Carbon Radioisotopes; Ephedrine; Isotope Labeling; Male; Methylation; Mice; Phenylpropanolamine; Theophylline; Time Factors; Tissue Distribution | 1978 |
[Mass spectrophotometric degradation of theophyllidine, caffeidine and the methylxanthines caffeine, theophylline and theobromine].
Topics: Caffeine; Chemical Phenomena; Chemistry; Drug Stability; Mass Spectrometry; Theobromine; Theophylline | 1978 |
Inhibition of skin carcinogenesis in vivo by caffeine and other agents.
Topics: Animals; Caffeine; Cell Line; Chloroquine; DNA; DNA Repair; Female; Malondialdehyde; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Theophylline; Ultraviolet Rays | 1978 |
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations.
Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug Synergism; Methylation; Mutation; Plants; Purines; Theobromine; Theophylline; Thiotepa; Uric Acid | 1975 |
A physicochemical analysis of conjugation in Tetrahymena pyriformis.
Topics: Amino Acids; Animals; Caffeine; Calcium; Colchicine; Conjugation, Genetic; Culture Media; Cycloheximide; Dactinomycin; Dithiothreitol; Egtazic Acid; Kinetics; Magnesium; Manganese; Potassium; Sodium; Temperature; Tetrahymena pyriformis; Theophylline; Zinc | 1976 |
Caffeine, theophylline, and human sperm motility.
Topics: Animals; Caffeine; Haplorhini; In Vitro Techniques; Male; Semen; Specimen Handling; Sperm Motility; Theophylline | 1976 |
The promoting ability of five accelerating agents for diazotization of several types of bilirubin samples.
Topics: Acetates; Benzoates; Bilirubin; Caffeine; Chemical Phenomena; Chemistry; Evaluation Studies as Topic; Humans; Indicators and Reagents; Jaundice; Theophylline; Urea | 1977 |
Inhibitory effect of xanthines on the incorporation of [14C]valine into proteins and on the secretion of albumin in isolated parenchymal rat liver cells.
Topics: Aminophylline; Animals; Caffeine; Female; In Vitro Techniques; Liver; Protein Biosynthesis; Rats; Serum Albumin; Theophylline; Valine | 1977 |
An assay for inorganic orthophosphate in the presence of alkaloids and related drugs.
Topics: Alkaloids; Atropine; Caffeine; Methods; Molybdenum; Phosphates; Quinine; Theophylline | 1977 |
Simultaneous assay of the methylxanthine metabolites of caffeine in plasma by high performance liquid chromatography.
Topics: Caffeine; Chromatography, Liquid; Humans; Theobromine; Theophylline; Xanthines | 1977 |
High performance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Theobromine; Theophylline; Xanthines | 1977 |
Effects of gastrointestinal hormones on the electrical and mechanical activity of the cat stomach.
Topics: Action Potentials; Animals; Atropine; Caffeine; Cats; Cholecystokinin; Gastrins; Gastrointestinal Hormones; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Secretin; Stomach; Tetrodotoxin; Theophylline; Verapamil | 1977 |
Action of caffeine and theophylline on staphylococcal penicillinase synthesis.
Topics: Caffeine; Penicillinase; Staphylococcus aureus; Theophylline | 1977 |
Methylxanthines and intestinal drug absorption.
Topics: Animals; Antipyrine; Caffeine; Female; Intestinal Absorption; Jejunum; Male; Pharmaceutical Preparations; Rats; Regional Blood Flow; Salicylates; Theophylline; Tritium; Urea; Water | 1976 |
Theophylline radioimmunoassay: synthesis of antigen and characterization of antiserum.
Topics: Animals; Antibody Formation; Caffeine; Cross Reactions; Female; Immune Sera; Male; Microchemistry; Rabbits; Radioimmunoassay; Saliva; Serum Albumin, Bovine; Theobromine; Theophylline | 1976 |
A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates.
Topics: Barbiturates; Caffeine; Humans; Hypoxanthines; Spectrophotometry, Ultraviolet; Theophylline; Uric Acid; Xanthines | 1976 |
[Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with liver disease].
Topics: Caffeine; Coffee; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Liver Diseases; Theophylline; Triglycerides | 1976 |
[Study on the effect of detection with iodine on the determination of aromatic compounds after their chromatographic separation, XII].
Topics: Aminopyrine; Antipyrine; Barbiturates; Caffeine; Chromatography, Thin Layer; Iodine; Mass Spectrometry; Theophylline | 1976 |
Quantitative determination of theophylline in pharmaceutical dosage forms by differential spectrophotometry.
Topics: Amobarbital; Caffeine; Capsules; Chemical Phenomena; Chemistry; Drug Stability; Ephedrine; Methods; Spectrophotometry, Ultraviolet; Tablets; Theobromine; Theophylline | 1976 |
A rapid and sensitive method for determination of theophylline in plasma and saliva by high pressure liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Methods; Saliva; Theobromine; Theophylline | 1976 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myocarditis; Myocardium; Necrosis; Oxygen Consumption; Propranolol; Rats; Theophylline; Verapamil | 1976 |
[Structure and organization of the contractile proteins at the level of the Z and M bands in the sartorius muscles of Rana esculenta treated with methylxanthine (MX)].
Topics: Animals; Caffeine; Muscle Contraction; Muscle Proteins; Muscles; Rana esculenta; Theophylline; Xanthines | 1976 |
The effect of methylxanthines on chromosomes of human lyphocytes in culture.
Topics: Caffeine; Cells, Cultured; Chromosomes; Humans; Lymphocytes; Mitosis; Mutagens; Theobromine; Theophylline; Time Factors; Xanthines | 1975 |
The xanthine treatment of apnea of prematurity.
Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Diseases; Prognosis; Theophylline; Xanthines | 1975 |
Gas-liquid chromatographic determination of theophylline in human plasma.
Topics: Caffeine; Chromatography, Gas; Hot Temperature; Humans; Methods; Methylation; Microchemistry; Theophylline | 1975 |
Action of dopamine receptor agonists in forebrain and hypothalamus: rotational behavior, ovulation, and dopamine turnover.
Topics: Animals; Apomorphine; Brain; Caffeine; Dopamine; Ergot Alkaloids; Female; Hypothalamus; Limbic System; Lysergic Acid Diethylamide; Models, Biological; Motor Activity; Ovulation; Piribedil; Receptors, Drug; Sexual Behavior, Animal; Stimulation, Chemical; Telencephalon; Theophylline | 1975 |
Stimulatory effect of the lysosomal stabilizer, chloroquine, on the respiration and motility of fresh and aged bovine spermatozoa.
Topics: Animals; Caffeine; Cattle; Chloroquine; In Vitro Techniques; Male; Oxygen Consumption; Sperm Motility; Sperm Tail; Spermatozoa; Stimulation, Chemical; Theophylline; Tissue Preservation | 1975 |
Effect of methylxanthines on hepatic microsomal enzymes in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Caffeine; Male; Microsomes, Liver; Nitroanisole O-Demethylase; Proteins; Rats; Theobromine; Theophylline; Time Factors | 1975 |
[Separation of caffeine, theophylline and theobromine with assistance from high pressure liquid chromatography].
Topics: Caffeine; Chromatography, High Pressure Liquid; Theobromine; Theophylline | 1975 |
The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells.
Topics: Animals; Caffeine; Cell Line; Chromosome Aberrations; Cricetinae; DNA; DNA Repair; Molecular Weight; Purines; Radiation Genetics; Theophylline; Ultraviolet Rays | 1975 |
A rapid and precise method for determining theophylline in serum.
Topics: Barbiturates; Caffeine; Humans; Methods; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1975 |
Which of caffeine's chemical relatives are able to evoke contractures in mammalian heart?
Topics: Animals; Caffeine; Guinea Pigs; Heart Ventricles; Imidazoles; In Vitro Techniques; Myocardial Contraction; Rats; Structure-Activity Relationship; Temperature; Theobromine; Theophylline; Ventricular Function; Xanthines | 1975 |
[Broncholytic effect of Atrovent in comparison with a combination preparation in obstructive lung diseases].
Topics: Adult; Aged; Atropa belladonna; Atropine; Bronchodilator Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Papaverine; Phenazines; Phytotherapy; Plants, Medicinal; Plants, Toxic; Theophylline; Tropanes | 1975 |
Determination of theophylline in plasma ultrafiltrate by reversed phase high pressure liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Methods; Theophylline; Ultrafiltration; Xanthines | 1976 |
The human metabolism of caffeine to theophylline.
Topics: Allopurinol; Aminophylline; Biological Availability; Caffeine; Humans; Male; Theophylline; Time Factors | 1976 |
Gas-chromatographic micro-scale procedure for theophylline, with use of a nitrogen-sensitive detector.
Topics: Caffeine; Chromatography, Gas; Humans; Microchemistry; Nitrogen; Phenobarbital; Saliva; Theobromine; Theophylline; Xanthines | 1976 |
Serum theophylline analysis by high-pressure liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Microchemistry; Structure-Activity Relationship; Theobromine; Theophylline | 1976 |
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Caffeine; Electroencephalography; Male; Parasympatholytics; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines | 1992 |
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
Topics: Biotransformation; Caffeine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA; Gene Expression; Humans; Oxidoreductases; Oxidoreductases, N-Demethylating; Theobromine; Theophylline; Vaccinia virus | 1992 |
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardium; Myosins; Rats; Rats, Wistar; Theophylline; Thyroid Hormones | 1992 |
Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicans.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine Nucleotides; Adenosine; Caffeine; Candida albicans; Cyclic AMP; Theophylline | 1992 |
Hypoxia-specific inhibition of recovery from radiation damage by a novel 2-nitroimidazole with a theophylline side chain.
Topics: Animals; Caffeine; Cell Hypoxia; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Theophylline | 1992 |
Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aqueous Humor; Caffeine; Cattle; Ciliary Body; Muscle Contraction; Perfusion; Phosphodiesterase Inhibitors; Theophylline | 1992 |
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid | 1992 |
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations.
Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline | 1992 |
A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites.
Topics: Adult; Caffeine; Evaluation Studies as Topic; Female; Humans; Liver; Liver Cirrhosis; Male; Methods; Middle Aged; Oxidation-Reduction; Theobromine; Theophylline | 1992 |
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Theophylline | 1992 |
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure.
Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Inositol; Male; Mice; Phenytoin; Structure-Activity Relationship; Theophylline; Uric Acid | 1992 |
Caffeine and theophylline contractures in tonic skeletal muscle fibers of the frog.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Contracture; Dose-Response Relationship, Drug; Electrophysiology; Muscle Contraction; Rana pipiens; Sarcoplasmic Reticulum; Theophylline | 1992 |
Behavioral evaluation of psycho-pharmacological and psychotoxic actions of methylxanthines by ambulatory activity and discrete avoidance in mice.
Topics: Animals; Avoidance Learning; Caffeine; Male; Methamphetamine; Mice; Motor Activity; Theobromine; Theophylline | 1992 |
Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.
Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; Oxidoreductases; Theophylline | 1992 |
Fluorescence quenching of human serum albumin by xanthines.
Topics: Caffeine; Humans; Serum Albumin; Spectrometry, Fluorescence; Temperature; Theobromine; Theophylline; Thermodynamics; Tryptophan; Xanthines | 1992 |
Pharmacodynamic interactions between isoniazid and theophylline in mice and rats, and the influence of pyridoxine.
Topics: Animals; Brain; Caffeine; Convulsants; Drug Interactions; Isoniazid; Male; Mice; Pyridoxine; Rats; Rats, Inbred Strains; Theophylline | 1992 |
Purinergic agonist induction of metallothionein.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cells, Cultured; Cladribine; Deoxyadenosines; Dose-Response Relationship, Drug; Immunoblotting; Liver; Male; Metallothionein; Rats; Rats, Inbred Strains; RNA, Messenger; Theophylline; Time Factors; Transcription, Genetic; Vasodilator Agents | 1992 |
Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants.
Topics: Apnea; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theobromine; Theophylline | 1992 |
Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Diet Records; Educational Status; Female; Hispanic or Latino; Humans; Milk, Human; Socioeconomic Factors; Theobromine; Theophylline; White People | 1992 |
[Behavioral study on reduction of psychotic and behavioral disorders induced by antitussive and expectorant].
Topics: Animals; Antitussive Agents; Avoidance Learning; Behavior, Animal; Caffeine; Expectorants; Male; Mice; Mice, Inbred Strains; Motor Activity; Psychoses, Substance-Induced; Theophylline | 1992 |
Caffeine concentrations in adult patients chronically taking theophylline.
Topics: Adult; Aged; Caffeine; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Theophylline | 1992 |
Theophylline metabolism affected by mexiletine.
Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines | 1992 |
Simultaneous determination of caffeine and its primary demethylated metabolites in human plasma by high-performance liquid chromatography.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Humans; Male; Middle Aged; Theobromine; Theophylline | 1992 |
Methylxanthines (caffeine and theophylline) blocked methamphetamine-induced conditioned place preference in mice but enhanced that induced by cocaine.
Topics: Animals; Caffeine; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Methamphetamine; Mice; Mice, Inbred Strains; Theophylline | 1992 |
A Monte Carlo simulation of hydration of xanthine-derivatives and their stacked forms.
Topics: Caffeine; Molecular Conformation; Monte Carlo Method; Theobromine; Theophylline; Thermodynamics; Water; Xanthines | 1992 |
Determination of substituted purines in body fluids by micellar electrokinetic capillary chromatography with direct sample injection.
Topics: Adult; Body Fluids; Caffeine; Chromatography; Electrophoresis; Humans; Infant; Purines; Saliva; Theophylline | 1992 |
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Cerebral Cortex; Colforsin; Cyclic AMP; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Histones; Mice; Neuroblastoma; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Theophylline; Tumor Cells, Cultured; Tyrosine | 1990 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; B-Lymphocytes; Blotting, Northern; Caffeine; Cell Line; Cyclic AMP; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Kinetics; Mice; Plasmids; Recombination, Genetic; RNA, Messenger; T-Lymphocytes; Theophylline; Transfection | 1990 |
Free calcium transients and oscillations in nerve cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Fura-2; Guanylyl Imidodiphosphate; Helix, Snails; Membrane Potentials; Microelectrodes; Neurons; Theophylline; Thymol; Xanthines | 1991 |
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
Topics: Animals; Biotransformation; Caffeine; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Genetic Engineering; Humans; Hydroxylation; Methylation; Mice; Rats; Species Specificity; Theophylline; Xanthines | 1992 |
Purinergic modulation of field stimulation responses of rat and human vas deferens smooth muscle.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Electric Stimulation; Guanethidine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinidine; Rats; Receptors, Purinergic; Theophylline; Urinary Bladder; Vas Deferens; Vasodilator Agents | 1991 |
Determination of theophylline in serum and saliva in the presence of caffeine and its metabolites.
Topics: Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Saliva; Theophylline | 1991 |
Xanthines inhibit 3T3 fibroblast proliferation.
Topics: 3T3 Cells; Animals; Caffeine; Cell Division; Dyphylline; Mice; Psoriasis; Theophylline; Xanthines | 1991 |
Somatic development of the infant monkey following in utero exposure to caffeine.
Topics: Animals; Body Weight; Caffeine; Female; Half-Life; Humans; Infant, Newborn; Macaca fascicularis; Male; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Teratogens; Theophylline | 1991 |
Methylxanthine-induced attenuation of pecking in chickens.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Behavior, Animal; Caffeine; Chickens; Dipyridamole; Female; Male; Theophylline; Xanthines | 1991 |
High-performance liquid chromatographic separation of caffeine, theophylline, theobromine and paraxanthine in rat brain and serum.
Topics: Animals; Brain Chemistry; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1991 |
Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives.
Topics: 2-Chloroadenosine; Adenosine; Affinity Labels; Animals; Biological Transport; Caffeine; Cells, Cultured; Cytarabine; Dipyridamole; Embryo, Mammalian; Hippocampus; Kinetics; Neuroglia; Neurons; Pentoxifylline; Rats; Sodium; Theophylline; Thioinosine; Tritium; Xanthines | 1991 |
Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bromocriptine; Caffeine; Dopamine; Male; Mice; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sulpiride; Synapses; Theophylline; Xanthines | 1991 |
Lack of pharmacokinetic interaction as an equivalence problem.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Adenosine Triphosphatases; Administration, Oral; Adult; Benzimidazoles; Caffeine; Drug Interactions; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Omeprazole; Pantoprazole; Pharmacokinetics; Sulfoxides; Theophylline; Therapeutic Equivalency | 1991 |
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea | 1991 |
Caffeine and theophylline as adenosine receptor antagonists in humans.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Aggregation; Purinergic Antagonists; Receptors, Purinergic; Substance Withdrawal Syndrome; Theophylline | 1991 |
Significance of partial and total cohesion parameters of pharmaceutical solids determined from dissolution calorimetric measurements.
Topics: Caffeine; Calorimetry; Dosage Forms; Drug Compounding; Models, Chemical; Phenylbutazone; Solubility; Technology, Pharmaceutical; Theophylline; Thermodynamics | 1991 |
[Micromethod for determination of theophylline/caffeine and chloramphenicol in plasma with HPLC].
Topics: Caffeine; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Microchemistry; Theophylline | 1991 |
Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Ephedrine; Male; Oxygen Consumption; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline; Xanthines | 1991 |
Dissociation between the effects of theophylline and caffeine on premature airway smooth muscles.
Topics: Acetylcholine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Female; Humans; Infant, Newborn; Isometric Contraction; Muscle Relaxation; Muscle, Smooth; Pregnancy; Respiratory Distress Syndrome, Newborn; Sheep; Theophylline; Trachea | 1991 |
Pharmacokinetic aspects of caffeine in premature infants.
Topics: Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature; Injections, Intravenous; Sleep Apnea Syndromes; Theophylline; Xanthines | 1991 |
Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline.
Topics: Adipose Tissue; Analysis of Variance; Animals; Brain; Caffeine; Dialysis; Extracellular Space; In Vitro Techniques; Least-Squares Analysis; Liver; Male; Muscles; Organ Specificity; Rats; Rats, Inbred Strains; Theophylline | 1991 |
Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain and other tissues in rats.
Topics: Adipose Tissue; Animals; Brain; Caffeine; Dialysis; Extracellular Space; Least-Squares Analysis; Liver; Male; Muscles; Rats; Rats, Inbred Strains; Theophylline | 1991 |
Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons.
Topics: Animals; Barium; Caffeine; Calcium Channels; Ganglia; Helix, Snails; In Vitro Techniques; Lypressin; Membrane Potentials; Neurons; Oxytocin; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 1990 |
Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity.
Topics: Caffeine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Mitosis; Theobromine; Theophylline; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xanthines | 1990 |
Characterization of metronidazole metabolism by human liver microsomes.
Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide | 1991 |
Effects of the anesthetics heptanol, halothane and isoflurane on gap junction conductance in crayfish septate axons: a calcium- and hydrogen-independent phenomenon potentiated by caffeine and theophylline, and inhibited by 4-aminopyridine.
Topics: 4-Aminopyridine; Alcohols; Anesthetics; Animals; Astacoidea; Axons; Caffeine; Calcium; Electric Conductivity; Halothane; Heptanol; Hydrogen-Ion Concentration; Intercellular Junctions; Isoflurane; Kinetics; Membrane Potentials; Theophylline | 1991 |
[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea].
Topics: Apnea; Asphyxia Neonatorum; Caffeine; Humans; Infant, Newborn; Monitoring, Physiologic; Theophylline | 1991 |
Interval dependence of force and twitch duration in rat heart explained by Ca2+ pump inactivation in sarcoplasmic reticulum.
Topics: Action Potentials; Animals; Biological Transport, Active; Biomechanical Phenomena; Caffeine; Calcium; Female; In Vitro Techniques; Male; Myocardial Contraction; Rats; Ryanodine; Sarcomeres; Sarcoplasmic Reticulum; Sodium; Strontium; Theophylline; Time Factors | 1990 |
Organic calcium channel antagonists provoke acetylcholine receptor autodesensitization on train stimulation of motor nerve.
Topics: Animals; Bungarotoxins; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diaphragm; Egtazic Acid; Electric Stimulation; Electrophysiology; Mice; Motor Endplate; Muscle Contraction; Neostigmine; Nicardipine; Phrenic Nerve; Receptors, Cholinergic; Theophylline | 1990 |
Urinary zinc excretion in infancy.
Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of Results; Specimen Handling; Spectrophotometry, Atomic; Theophylline; Zinc | 1990 |
The effects of caffeine and theophylline on the triple adenosine triphosphatase enzyme activities of spermatozoa from males with oligoasthenospermia.
Topics: Adenosine Triphosphatases; Caffeine; Humans; Male; Sperm Motility; Spermatozoa; Theophylline | 1990 |
Relationships between adenylate cyclase and Na+, K(+)-ATPase in rat pancreatic islets.
Topics: Adenylyl Cyclases; Animals; Brain; Bucladesine; Caffeine; Cell Membrane; In Vitro Techniques; Islets of Langerhans; Kidney Medulla; Kinetics; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Swine; Theophylline | 1990 |
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines | 1990 |
Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; C-Reactive Protein; Caffeine; Calcimycin; Calcium; Carcinoma, Hepatocellular; Colforsin; Cyclic AMP; Drug Synergism; Humans; Interleukin-1; Interleukin-6; Ionomycin; Liver Neoplasms; Recombinant Proteins; Second Messenger Systems; Theophylline; Tumor Cells, Cultured | 1990 |
Determination of anticonvulsant drugs and methyl xanthine derivatives in serum by liquid chromatography with direct injection: column-switching method using a new internal-surface reversed-phase silica support as a precolumn.
Topics: Anticonvulsants; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Phenobarbital; Phenytoin; Primidone; Silicon Dioxide; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines | 1990 |
Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes.
Topics: Animals; Benzazepines; Binding, Competitive; Brain; Caffeine; Corpus Striatum; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Membranes; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Theophylline | 1990 |
Recombinagenicity of caffeine for Candida albicans.
Topics: Adenine; Caffeine; Candida albicans; Cell Division; Culture Media; DNA Damage; DNA Repair; DNA, Fungal; Drug Resistance, Microbial; Flucytosine; Mutation; Phenotype; Recombination, Genetic; Temperature; Theophylline | 1990 |
The effect of methylxanthines on milk volume and composition, and growth of rat pups.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Fatty Acids; Female; Lactation; Milk; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Time Factors; Xanthines | 1990 |
Do-Do abuse.
Topics: Adult; Antitussive Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline | 1990 |
Caffeine and theophylline attenuate adenosine-induced vasodilation in humans.
Topics: Adenosine; Adolescent; Adult; Bronchodilator Agents; Caffeine; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Theophylline; Vasodilation; Xanthines | 1990 |
Isobolographic assessment of the convulsant interaction between theophylline and caffeine or pentylenetetrazol in rats.
Topics: Animals; Caffeine; Convulsants; Drug Interactions; Infusions, Intravenous; Male; Models, Biological; Pentylenetetrazole; Rats; Rats, Inbred Strains; Theophylline | 1990 |
Effect of methylxanthines on lactational performance of rats.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Drinking; Eating; Female; Lactation; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1990 |
Adenosine involvement in postictal events in amygdala-kindled rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Caffeine; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Kindling, Neurologic; Male; Rats; Seizures; Theophylline; Time Factors | 1990 |
HPLC analysis of methylxanthines in human breast milk.
Topics: Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Milk, Human; Temperature; Theobromine; Theophylline; Xanthines | 1990 |
Methylcholanthrene but not phenobarbital enhances caffeine and theophylline metabolism in cultured adult human hepatocytes.
Topics: Adult; Biotransformation; Caffeine; Cells, Cultured; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Theophylline | 1990 |
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Simpler measurement of caffeine and paraxanthine in saliva.
Topics: Autoanalysis; Caffeine; Humans; Saliva; Theophylline | 1990 |
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobromine; Theophylline | 1990 |
Maternal caffeine ingestion increases the tyrosine level in neonatal rat cerebrum.
Topics: Amino Acids; Animals; Animals, Newborn; Animals, Suckling; Brain; Caffeine; Female; Liver; Maternal-Fetal Exchange; Methoxyhydroxyphenylglycol; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Theophylline; Tyrosine | 1990 |
Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans.
Topics: Adult; Caffeine; Fatty Acids, Nonesterified; Glycerol; Humans; Injections, Intravenous; Lipid Mobilization; Lipolysis; Male; Theophylline | 1990 |
Transcutaneous theophylline collection in preterm infants.
Topics: Age Factors; Caffeine; Diffusion; Humans; Infant, Newborn; Infant, Premature; Lung Diseases; Methods; Permeability; Skin; Theophylline | 1990 |
Human N-acetylation genotype determination with urinary caffeine metabolites.
Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines | 1990 |
Caffeine and methylxanthines.
Topics: Caffeine; Dipyridamole; Drug Interactions; Humans; Theophylline | 1990 |
[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants].
Topics: Bradycardia; Caffeine; Citrates; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Determination; Gastroesophageal Reflux; Humans; Infant, Newborn; Respiration; Respiratory Distress Syndrome, Newborn; Sleep Apnea Syndromes; Theophylline | 1990 |
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, Purinergic; Theophylline; Trachea; Xanthines | 1990 |
Simultaneous analysis of theophylline, caffeine and eight of their metabolic products in human plasma by gradient high-performance liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Xanthines | 1990 |
Methylxanthines inhibit glucose transport in rat adipocytes by two independent mechanisms.
Topics: Adipose Tissue; Animals; Caffeine; Cell Membrane; Glucose; Rats; Rats, Inbred Strains; Theophylline; Xanthines | 1990 |
Determination of carcinogenic arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites.
Topics: Acetylation; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Cytochrome P-450 Enzyme System; Disease Susceptibility; Humans; Isoenzymes; Oxidation-Reduction; Phenotype; Theophylline; Uracil; Urinary Bladder Neoplasms; Xanthines | 1990 |
A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors.
Topics: Animals; Brain; Caffeine; Flavins; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reference Values; Sleep; Sleep Stages; Sleep, REM; Theophylline | 1990 |
[Action of cyclic nucleotide phosphodiesterase inhibitors on the acetylcholine potential].
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Bucladesine; Caffeine; Diaphragm; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Theophylline | 1985 |
Regulation of galactokinase gene expression in Tetrahymena thermophila. I. Intracellular catecholamine control of galactokinase expression.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Caffeine; Catecholamines; Cyclic AMP; Galactokinase; Genes; Glucagon; Glucose; Histamine; Insulin; Kinetics; Tetrahymena; Theophylline | 1985 |
Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Chlordiazepoxide; Conditioning, Psychological; Male; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Saimiri; Theobromine; Theophylline; Xanthines | 1985 |
The effect of caffeine on mouse striatal tryptamine.
Topics: Animals; Caffeine; Corpus Striatum; Hydroxyindoleacetic Acid; Male; Mice; Pargyline; Serotonin; Theophylline; Tryptamines; Tryptophan | 1985 |
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Glucose; Glucose-6-Phosphate; Glucosephosphates; Liver; Male; Phosphoprotein Phosphatases; Rats; Structure-Activity Relationship; Theobromine; Theophylline; Time Factors; Xanthine; Xanthines | 1986 |
Lack of a sustained effect on catecholamines or indoles in mouse brain after long term subcutaneous administration of caffeine and theophylline.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Caffeine; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; Norepinephrine; Serotonin; Theophylline | 1986 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines | 1986 |
Enhancement and suppression of currents related to calcium-overload by different concentrations of methylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Ion Channels; Male; Microelectrodes; Purkinje Fibers; Sheep; Theophylline; Xanthines | 1986 |
Effect of chronically administered methylxanthines on ethanol-induced motor incoordination in mice.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Caffeine; Drug Synergism; Ethanol; Kinetics; Male; Mice; Motor Activity; Receptors, Purinergic; Theophylline; Xanthines | 1986 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Behavioral interactions of ethanol and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Posture; Psychomotor Performance; Reflex; Theophylline; Xanthines | 1987 |
Effects of methylxanthines on cell-cycle redistribution and sensitization to killing by low-dose-rate radiation.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cell Cycle; Cell Survival; Humans; Radiation Dosage; Radiation Tolerance; Theophylline; Tumor Cells, Cultured | 1988 |
Effects of caffeine and 3-isobutyl 1-methyl xanthine on caprine milk secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Fats; Female; Goats; Infusions, Intravenous; Injections, Intramuscular; Lactation; Milk; Milk Proteins; Pregnancy; Theophylline | 1988 |
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cholera Toxin; Colforsin; Cyclic AMP; Evoked Potentials; Fluorides; In Vitro Techniques; Mice; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Theophylline | 1988 |
Calcium dependence of rhythmic contractions of the Oryzias latipes blastoderm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastoderm; Bucladesine; Caffeine; Calcium; Calcium Channel Blockers; Cyprinodontiformes; Oryzias; Papaverine; Theophylline | 1988 |
Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Calcium; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Theophylline | 1988 |
Cyclic nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid hormone and 16,16-dimethyl prostaglandin E2 in chicks.
Topics: 1-Methyl-3-isobutylxanthine; 16,16-Dimethylprostaglandin E2; Animals; Bone and Bones; Bucladesine; Caffeine; Calcium; Calcium Radioisotopes; Chickens; Cyclic AMP; Male; Nucleotides, Cyclic; Parathyroid Hormone; Peptide Fragments; Prostaglandins E, Synthetic; Theophylline | 1989 |
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Psychomotor Performance; Reinforcement Schedule; Saimiri; Stimulation, Chemical; Theophylline | 1989 |
Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Adrenergic beta-Agonists; Animals; Caffeine; Drug Interactions; Epinephrine; Isoproterenol; Lipids; Male; Propranolol; Swine; Theophylline | 1989 |
[Plasma determination of 7 common drugs by high performance liquid chromatography].
Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid | 1989 |
Presence and properties of cAMP phosphodiesterase from promastigote forms of Leishmania tropica and Leishmania donovani.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Leishmania donovani; Leishmania tropica; Magnesium; Phenobarbital; Substrate Specificity; Temperature; Theophylline; Trifluoperazine | 1989 |
The influence of structure on the accumulation of caffeine induced by methyl xanthine derivatives.
Topics: Animals; Caffeine; Male; Rats; Rats, Inbred Strains; Theophylline; Xanthines | 1989 |
Methylxanthines augment the renin response to suprarenal-aortic constriction.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Blood Pressure; Caffeine; Dogs; Hemodynamics; Hypertension, Renovascular; Kidney; Renal Circulation; Renin; Theophylline; Xanthines | 1989 |
Methyl xanthines enhance taste: evidence for modulation of taste by adenosine receptor.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Animals; Caffeine; Female; Humans; In Vitro Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Taste; Theobromine; Theophylline; Xanthines | 1985 |
Methylxanthine effects on caudate dopamine release as measured by in vivo electrochemistry.
Topics: Anesthesia; Animals; Caffeine; Caudate Nucleus; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Extracellular Space; Male; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline; Urethane; Xanthines | 1989 |
The effect of adenosine and adenosine analogues on methylxanthine-induced hypercalciuria in the rat.
Topics: Adenosine; Animals; Body Weight; Caffeine; Calcium; Diet; Diuresis; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1989 |
Non-extraction HPLC method for the simultaneous measurement of theophylline and caffeine in human serum.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline; Xanthines | 1989 |
Theophylline does not increase maximal tetanic force or diaphragm endurance in vitro.
Topics: Animals; Caffeine; Cricetinae; Diaphragm; Electric Stimulation; Male; Mesocricetus; Muscle Contraction; Physical Endurance; Rats; Rats, Inbred Strains; Temperature; Theophylline | 1989 |
[DNA repair and drug resistance: enhancement of the effects of anticancer agents by DNA repair inhibitors].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Cell Division; Child; Cisplatin; DNA Repair; Doxorubicin; Drug Resistance; Drug Synergism; Humans; Male; Middle Aged; Osteosarcoma; Pentoxifylline; Theophylline; Tumor Cells, Cultured | 1989 |
The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease.
Topics: Adult; Aged; Caffeine; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theobromine; Theophylline | 1989 |
Caffeine pharmacokinetics in preterm infants older than 2 weeks.
Topics: Caffeine; Chromatography, High Pressure Liquid; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Sleep Apnea Syndromes; Theophylline | 1989 |
Excretion and metabolism of a series of xanthines by the turtle Pseudemys scripta elegans.
Topics: Animals; Caffeine; Theobromine; Theophylline; Turtles; Uric Acid; Xanthine; Xanthines | 1989 |
Interaction of caffeine and of theophylline with liver glutamate dehydrogenase.
Topics: Adenosine Diphosphate; Animals; Binding, Competitive; Caffeine; Cattle; Glutamate Dehydrogenase; Kinetics; Liver; Rats; Species Specificity; Theophylline | 1989 |
Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior.
Topics: Aggression; Animals; Azepines; Caffeine; Clonidine; Dilazep; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Phenylisopropyladenosine; Purines; Theophylline | 1989 |
Comparison of fluorescence polarization immunoassay and HPLC for the determination of theophylline in serum.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cross Reactions; Fluorescence Polarization; Humans; Immunoassay; Indicators and Reagents; Theophylline | 1989 |
Interaction between oral ciprofloxacin and caffeine in normal volunteers.
Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Half-Life; Humans; Male; Theophylline | 1989 |
Use of flavor-amplified foods to improve nutritional status in elderly patients.
Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Monophosphate; Nutritional Status; Smell; Taste; Theobromine; Theophylline | 1989 |
Caffeine-induced Ca2+ release activates Ca2+ extrusion via Na+-Ca2+ exchanger in cardiac myocytes.
Topics: Animals; Benzofurans; Caffeine; Calcium; Carrier Proteins; Electric Conductivity; Fluorescent Dyes; Fura-2; Guinea Pigs; Heart; Kinetics; Membrane Potentials; Myocardium; Nickel; Rats; Sodium; Sodium-Calcium Exchanger; Theophylline | 1989 |
Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers.
Topics: Animals; Caffeine; Calcium; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Glycolysis; Heart Conduction System; Male; Methoxamine; Myocardial Contraction; Norepinephrine; Potassium; Propranolol; Purkinje Fibers; Theophylline | 1989 |
Felodipine reduces the absorption of theophylline in man.
Topics: Adult; Blood Pressure; Caffeine; Calcium Channel Blockers; Drug Interactions; Felodipine; Humans; Intestinal Absorption; Male; Nitrendipine; Theophylline | 1989 |
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random Allocation; Seizures; Theophylline; Xanthines | 1989 |
Effects of passive smoking on theophylline clearance.
Topics: Adult; Caffeine; Cotinine; Diet; Female; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nicotine; Theophylline; Tobacco Smoke Pollution | 1989 |
Involvement of cAMP in initiating maturation of the brittle-star Amphipholis kochii oocytes: induction of oocyte maturation by inhibitors of cyclic nucleotide phosphodiesterase and activators of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Caffeine; Calmodulin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Hydrogen-Ion Concentration; Oocytes; Radioimmunoassay; Starfish; Theophylline | 1988 |
Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions.
Topics: Allosteric Regulation; Animals; Caffeine; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Receptors, GABA-A; Theophylline; Time Factors | 1988 |
The effect of glucose on liver glycogen synthase phosphatase activity in the presence of ATP-Mg.
Topics: Adenosine Triphosphate; Animals; Caffeine; Drug Stability; Glucose; Glucose-6-Phosphate; Glucosephosphates; Glycogen-Synthase-D Phosphatase; Liver; Magnesium; Male; Phosphoprotein Phosphatases; Protease Inhibitors; Rats; Rats, Inbred Strains; Substrate Specificity; Theophylline | 1988 |
Modification of myofibrillar responsiveness to Ca++ as an inotropic mechanism.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aequorin; Animals; Caffeine; Calcium; Cardiotonic Agents; Cats; Cyclic AMP; Dogs; Guinea Pigs; Hydrogen-Ion Concentration; Imidazoles; Muscles; Myocardial Contraction; Myofibrils; Rabbits; Rats; Sarcoplasmic Reticulum; Theophylline; Troponin; Troponin C | 1986 |
Lack of effect of nizatidine on hepatic drug metabolism in man.
Topics: Adult; Blood Proteins; Caffeine; Chlordiazepoxide; Histamine H2 Antagonists; Humans; Kinetics; Liver; Lorazepam; Male; Nizatidine; Pharmaceutical Preparations; Protein Binding; Theophylline; Thiazoles | 1985 |
Amphetamine-like effects of anorectics and related compounds in pigeons.
Topics: Amphetamines; Animals; Appetite Depressants; Bupropion; Caffeine; Chlorphentermine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Mazindol; Propiophenones; Propylamines; Theophylline | 1987 |
Changes induced by caffeine, theophylline and theobromine on calcium uptake, respiration and ATP levels in rat-liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Female; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1988 |
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine.
Topics: Acetylation; Adult; Allopurinol; Caffeine; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Kidney; Male; Metabolic Clearance Rate; Theophylline | 1989 |
Correlation of caffeine elimination and Child's classification in liver cirrhosis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Theobromine; Theophylline | 1989 |
Effect of poly(adenosinediphosphoribose) synthesis inhibitors and structurally related compounds on radiation-induced G2 arrest.
Topics: Aminobenzoates; Animals; Benzamides; Caffeine; Cell Line; Cricetinae; Deoxyadenosines; Interphase; meta-Aminobenzoates; Niacin; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline | 1988 |
On the mechanism of action of theophylline and caffeine.
Topics: Adenosine; Asthma; Caffeine; Calcium; Cyclic AMP; Humans; Muscle Contraction; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1985 |
Methylxanthine discrimination in the rat: possible benzodiazepine and adenosine mechanisms.
Topics: Animals; Caffeine; Chlordiazepoxide; Conditioning, Operant; Cues; Discrimination Learning; Male; Papaverine; Pentobarbital; Phenylisopropyladenosine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; Theophylline | 1985 |
Effect of poly(adenosine diphosphate-ribose) polymerase inhibitors on neocarzinostatin-induced G2 delay in HeLa-S3 cells.
Topics: Antibiotics, Antineoplastic; Caffeine; Cell Cycle; Cells, Cultured; DNA Repair; HeLa Cells; Humans; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Theophylline; Thymidine; Zinostatin | 1985 |
Effects of caffeine on transport, metabolism and ultrastructure of isolated rat colon.
Topics: Animals; Biological Transport, Active; Bucladesine; Butyrates; Caffeine; Colon; Glucose; Intestinal Absorption; Male; Microvilli; Rats; Rats, Inbred Strains; Sodium; Theophylline | 1985 |
A caffeine analogue (1,3,7-trimethyl-6-thioxo-2-oxopurine) with a negative inotropic and chronotropic effect.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Depression, Chemical; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Muscle Proteins; Myocardial Contraction; Myocardium; Phosphoric Diester Hydrolases; Theophylline; Xanthines | 1985 |
Regulation of energy expenditure in brown adipose tissue.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Body Temperature Regulation; Bucladesine; Caffeine; Cold Temperature; Dose-Response Relationship, Drug; Energy Metabolism; Female; Hyperphagia; Models, Biological; Norepinephrine; Oxygen Consumption; Palmitic Acid; Palmitic Acids; Physical Exertion; Propranolol; Rats; Rats, Inbred Strains; Temperature; Theophylline | 1985 |
Effects of caffeine and 8-phenyltheophylline on the actions of purines and opiates in the guinea-pig ileum.
Topics: Adenosine; Animals; Caffeine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Nalorphine; Norepinephrine; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1986 |
Inhibitory effects of theophylline and dibutyryl cAMP on murine erythroleukemia cell differentiation.
Topics: Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Cyclic AMP; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Synergism; Erythropoiesis; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Theophylline | 1986 |
[Methylxanthines and enzymes which degrade adenine nucleotides].
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Deaminase; Animals; Brain; Caffeine; Female; Guinea Pigs; Liver; Male; Nucleotidases; Purine-Nucleoside Phosphorylase; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1986 |
Metabolism of glucose by preimplantation mouse embryos in the presence of glucagon, insulin, epinephrine, cAMP, theophylline and caffeine.
Topics: Animals; Blastocyst; Caffeine; Carbon Radioisotopes; Cleavage Stage, Ovum; Cyclic AMP; Epinephrine; Female; Glucagon; Glucose; Insulin; Kinetics; Mice; Morula; Organ Culture Techniques; Theophylline | 1985 |
Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Male; Psychomotor Performance; Receptors, Purinergic; Saimiri; Stimulation, Chemical; Theophylline; Xanthines | 1988 |
[Theophylline-caffeine interaction in bronchial disease patients with cardiac and hepatic failure].
Topics: Adult; Bronchial Diseases; Caffeine; Drug Interactions; Heart Diseases; Humans; Liver Diseases; Theophylline | 1985 |
[Analysis and importance of levels of caffeine and theophylline in cord blood of premature newborn infants].
Topics: Caffeine; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Theophylline | 1988 |
Xanthine derivatives: could a further study of the mechanisms of action yield new therapeutic agents?
Topics: Caffeine; Humans; Theobromine; Theophylline | 1988 |
Quality control in therapeutic drug monitoring.
Topics: Caffeine; Flunitrazepam; Gentamicins; Humans; Laboratories; Netherlands; Pharmaceutical Preparations; Quality Control; Reference Values; Theophylline; Thiopental; United States | 1988 |
New methylxanthine thio-derivatives inducing marked tracheal relaxation without increasing cardiac inotropism or motor activity.
Topics: Animals; Caffeine; Guinea Pigs; In Vitro Techniques; Mice; Motor Activity; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Theophylline; Trachea | 1988 |
Evaluation of a rapid theophylline test strip assay in the emergency department setting.
Topics: Caffeine; Emergency Service, Hospital; Evaluation Studies as Topic; Humans; Prospective Studies; Reagent Strips; Theophylline | 1988 |
Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes.
Topics: Adult; Age Factors; Animals; Caffeine; Cells, Cultured; Cytochrome P-450 Enzyme System; Female; Humans; Infant, Newborn; Liver; Male; Rats; Rats, Inbred Strains; Species Specificity; Theophylline | 1988 |
Slowing of relaxation in the fatiguing hamster diaphragm is enhanced by theophylline.
Topics: Animals; Caffeine; Calcium; Cricetinae; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contraction; Muscle Relaxation; Theophylline; Verapamil | 1988 |
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred DBA; Motor Activity; Reference Values; Theobromine; Theophylline | 1988 |
Increases in plasma concentrations of steroids in the rat after the administration of caffeine: comparison with plasma disposition of caffeine.
Topics: Animals; Caffeine; Corticosterone; Liver; Male; Progesterone; Rats; Rats, Inbred Strains; Sodium; Stress, Physiological; Testosterone; Theobromine; Theophylline | 1988 |
The relationship between theophylline, caffeine and heart rate in neonates.
Topics: Aminophylline; Apnea; Caffeine; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Theophylline; Xanthines | 1988 |
Caffeine as a potential risk factor for theophylline neurotoxicity.
Topics: Animals; Blood Proteins; Brain; Caffeine; Dialysis; Injections, Intravenous; Male; Nervous System Diseases; Protein Binding; Rats; Rats, Inbred Strains; Risk Factors; Seizures; Theophylline | 1988 |
[Pharmacokinetics of caffeine and dimethylxanthines in plasma and saliva].
Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Models, Biological; Pregnancy; Saliva; Theophylline | 1988 |
[Studies on gas chromatographic quantitative determination and identification of compound tablets of theophylline].
Topics: Caffeine; Chromatography, Gas; Drug Combinations; Ephedrine; Phenacetin; Theophylline | 1988 |
Rapid development of functional tolerance to caffeine-induced seizures in rats.
Topics: Animals; Brain; Caffeine; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobromine; Theophylline | 1988 |
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies.
Topics: Adult; Benzoflavones; Caffeine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Humans; Immunologic Techniques; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Verapamil | 1988 |
Caffeine disposition in the pregnant rabbit. I. Pharmacokinetics following administration by intravenous bolus and continuous zero-order infusion.
Topics: Animals; Caffeine; Female; Infusion Pumps; Infusions, Intravenous; Kinetics; Male; Pregnancy; Pregnancy, Animal; Rabbits; Theophylline; Time Factors | 1988 |
Caffeine disposition in the pregnant rabbit. II. Fetal distribution of caffeine and paraxanthine during chronic maternal caffeine administration.
Topics: Albumins; Amniotic Fluid; Animals; Caffeine; Female; Fetal Proteins; Fetus; Infusions, Intravenous; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Protein Binding; Rabbits; Serum Albumin; Theophylline; Tissue Distribution | 1988 |
Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dextroamphetamine; Drug Tolerance; Male; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline | 1988 |
Isocratic liquid chromatographic determination of theophylline, acetaminophen, chloramphenicol, caffeine, anticonvulsants, and barbiturates in serum.
Topics: Acetaminophen; Anticonvulsants; Barbiturates; Caffeine; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Theophylline | 1988 |
Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.
Topics: Abortion, Veterinary; Animals; Birth Weight; Body Weight; Caffeine; Female; Fetal Death; Macaca fascicularis; Pregnancy; Pregnancy Outcome; Theophylline | 1988 |
Simultaneous ion-pair and partition liquid chromatography of acetaminophen, theophylline and salicylate with application to 500 toxicologic specimens.
Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Humans; Salicylates; Spectrophotometry, Ultraviolet; Theophylline | 1988 |
Apnea in infancy: pathophysiology, diagnosis, and treatment.
Topics: Aminophylline; Apnea; Caffeine; Chemoreceptor Cells; Home Nursing; Humans; Infant; Infant, Newborn; Monitoring, Physiologic; Pulmonary Gas Exchange; Sudden Infant Death; Theophylline | 1986 |
Contribution of electrostatic and hydrophobic interactions of bitter substances with taste receptor membranes to generation of receptor potentials.
Topics: Adsorption; Animals; Caffeine; Cell Line; Electricity; In Vitro Techniques; Membrane Fluidity; Membrane Potentials; Mice; Osmolar Concentration; Quinine; Rana catesbeiana; Solubility; Strychnine; Taste; Taste Buds; Theophylline | 1986 |
A rapid HPLC method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns.
Topics: Caffeine; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Fluorescence Polarization; Humans; Immunoassay; Immunoenzyme Techniques; Quality Control; Theophylline | 1986 |
Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture.
Topics: Animals; Body Temperature Regulation; Body Weight; Caffeine; Drug Therapy, Combination; Eating; Energy Intake; Energy Metabolism; Ephedrine; Food Deprivation; Male; Obesity; Rats; Rats, Zucker; Theophylline | 1987 |
Methylxanthine treatment of rats reduces 2,5-oligoadenylate synthesis in liver nuclei.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Caffeine; Cell Nucleus; Liver; Male; Poly I-C; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1987 |
Effects of N6-(L-phenylisopropyl)adenosine, caffeine, theophylline and rolipram on the acquisition of conditioned responses in the rabbit.
Topics: Adenosine; Animals; Caffeine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Phenylisopropyladenosine; Pyrrolidinones; Rabbits; Rolipram; Theophylline | 1987 |
Renal effects of theophylline and caffeine in newborn rabbits.
Topics: Animals; Animals, Newborn; Caffeine; Glomerular Filtration Rate; Kidney; Rabbits; Renal Circulation; Theophylline; Vascular Resistance | 1987 |
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, Nonmammalian; Emetine; Fluorouracil; Hydroxyurea; Theobromine; Theophylline; Xanthines; Xenopus laevis | 1987 |
Reactions of theophylline, theobromine and caffeine with Fenton's reagent--simulation of hepatic metabolism.
Topics: Caffeine; Hydrogen Peroxide; Hydroxylation; Iron; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Theobromine; Theophylline | 1987 |
Chronic exposure to subcutaneously implanted methylxanthines. Differential elevation of A1-adenosine receptors in mouse cerebellar and cerebral cortical membranes.
Topics: Animals; Caffeine; Cerebellum; Cerebral Cortex; Delayed-Action Preparations; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; Receptors, Purinergic; Theophylline | 1987 |
Effects of maternal caffeine ingestion on the perinatal cerebrum.
Topics: Animals; Body Weight; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Organ Size; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Therapeutic drug monitoring in a pediatric laboratory.
Topics: Anticonvulsants; Caffeine; Child; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Monitoring, Physiologic; Pharmaceutical Preparations; Theophylline | 1987 |
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Inbred Strains; Theophylline; Time Factors | 1987 |
Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects.
Topics: Animals; Caffeine; Female; Half-Life; Kinetics; Protein Binding; Rabbits; Theophylline; Ultrafiltration | 1987 |
An animal model for the detection of drug-induced inhibition of caffeine metabolism.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Depression, Chemical; Drug Interactions; Ethanolamines; Female; Male; Models, Biological; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Ion-pair high-performance liquid chromatographic procedure for the quantitative analysis of theophylline in serum samples.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Immunoassay; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline; Xanthines | 1987 |
Determination of partial and total cohesion parameters of caffeine, theophylline, and methyl p-hydroxybenzoate by gas-solid chromatography.
Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Chromatography; Mathematics; Parabens; Solubility; Theophylline; Thermodynamics | 1987 |
Evidence that adenosine mediates the depression of spinal dorsal horn neurons induced by peripheral vibration in the cat.
Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Caffeine; Cats; Dipyridamole; Injections, Intravenous; Iontophoresis; Naloxone; Neurons; Spinal Cord; Strychnine; Theophylline; Vibration | 1987 |
Pro-convulsant actions of theophylline and caffeine in the hippocampus: implications for the management of temporal lobe epilepsy.
Topics: Animals; Caffeine; Convulsants; Drug Interactions; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline | 1987 |
Agonist interactions at the calcium pools in skinned and unskinned canine tracheal smooth muscle.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Dogs; Female; Histamine; In Vitro Techniques; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Serotonin; Theophylline; Trachea | 1987 |
Determination of the urinary metabolites of caffeine and theophylline by high-performance liquid chromatography. A comparative study of a direct injection and an ion-pair extraction procedure.
Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Theophylline | 1986 |
Infant apnea.
Topics: Airway Obstruction; Apnea; Bradycardia; Caffeine; Cardiography, Impedance; Home Nursing; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Monitoring, Physiologic; Risk; Sleep; Sudden Infant Death; Theophylline; Xanthines | 1986 |
Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome.
Topics: Administration, Oral; Caffeine; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Infant; Monitoring, Physiologic; Posture; Risk; Sudden Infant Death; Theophylline; Time Factors | 1986 |
Inherent differences in sensitivity to methylxanthines among inbred mice.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Resistance; Mice; Mice, Inbred Strains; Motor Activity; Species Specificity; Theobromine; Theophylline; Time Factors; Xanthines | 1986 |
Complex genetic determinants of susceptibility to methylxanthine-induced locomotor activity changes.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Genetics, Behavioral; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Motor Activity; Theophylline; Xanthines | 1986 |
Effects of dietary protein on theophylline pharmacokinetics and caffeine and aminopyrine breath tests.
Topics: Adult; Aminopyrine; Aminopyrine N-Demethylase; Breath Tests; Caffeine; Dietary Proteins; Humans; Infusions, Parenteral; Kinetics; Male; Theophylline | 1986 |
[Effect of theophylline and caffeine on sensory retinal function in the human].
Topics: Adolescent; Adult; Caffeine; Humans; Male; Retina; Theophylline; Vision Tests; Visual Perception | 1986 |
The influence of phosphodiesterase inhibitors on ERG and optic nerve response of the cat.
Topics: Animals; Caffeine; Cats; Dark Adaptation; Electroretinography; Female; Imidazoles; Male; Optic Nerve; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Retina; Theophylline | 1986 |
Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat.
Topics: Animals; Blood Flow Velocity; Brain; Caffeine; Cerebrovascular Circulation; Glucose; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1986 |
Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Theophylline | 1986 |
Changes in theophylline metabolism during postnatal development in rat liver slices.
Topics: Allopurinol; Animals; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Liver; Proadifen; Rats; Theobromine; Theophylline | 1986 |
Effect of chronic exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings.
Topics: Animals; Brain; Caffeine; Diazepam; Female; Lactation; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Synaptosomes; Theophylline | 1986 |
Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.
Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline | 1986 |
Quantitative assessment of caffeine partial clearances in man.
Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline | 1986 |
Simple and sensitive method for the simultaneous determination of enprofylline, theobromine, paraxanthine, theophylline and caffeine using high-performance liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines | 1986 |
Urinary metabolites of caffeine in pregnant women.
Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines | 1986 |
Reduction of liver plasma flow by caffeine and theophylline.
Topics: Adenosine; Adult; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Humans; Indocyanine Green; Kinetics; Liver Circulation; Male; Middle Aged; Norepinephrine; Theophylline | 1986 |
Methylxanthines reduce in vitro human overall platelet metabolism as measured by microcalorimetry.
Topics: Blood Platelets; Body Temperature Regulation; Caffeine; Calorimetry; Humans; Theophylline; Xanthines | 1986 |
Toxicokinetics of caffeine elimination in an infant.
Topics: Caffeine; Female; Gas Chromatography-Mass Spectrometry; Glucose; Heart Rate; Humans; Infant; Kinetics; Respiration, Artificial; Theophylline | 1986 |
[Interaction between caffeine and theophylline].
Topics: Adult; Caffeine; Drug Interactions; Humans; Injections, Intravenous; Metabolic Clearance Rate; Middle Aged; Theophylline | 1986 |
Elimination of chronically consumed caffeine in the pregnant monkey (Macaca fascicularis).
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Drinking; Eating; Female; Macaca fascicularis; Pregnancy; Pregnancy, Animal; Theophylline; Uric Acid | 1986 |
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Female; Limb Deformities, Congenital; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Pregnancy; Theobromine; Theophylline | 1986 |
Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline.
Topics: Adenosine; Blood Pressure; Brain; Caffeine; Heart Rate; Hemodynamics; Receptors, Purinergic; Theophylline | 1987 |
[Peculiarities of drug therapy in childhood].
Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; Drug Therapy; Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Receptors, Drug; Theophylline; Tissue Distribution | 1986 |
Accumulation of caffeine in healthy volunteers treated with furafylline.
Topics: Administration, Oral; Adult; Caffeine; Drug Interactions; Drug Tolerance; Female; Humans; Kinetics; Male; Sex Factors; Theophylline | 1987 |
Theophylline and caffeine disposition in the neonatal piglet.
Topics: Animals; Animals, Newborn; Caffeine; Kinetics; Swine; Theophylline | 1986 |
Prevention of genetic fa/fa obesity with an ephedrine-methylxanthines thermogenic mixture.
Topics: Animals; Body Composition; Body Temperature Regulation; Caffeine; Energy Intake; Energy Metabolism; Ephedrine; Food Deprivation; Obesity; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Effects of caffeine and theophylline on the fecundity of four lepidopteran species.
Topics: Animals; Bombyx; Caffeine; Fertility; Lepidoptera; Theophylline | 1985 |
[Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk].
Topics: Caffeine; Female; Fetal Blood; Humans; Infant, Premature; Kinetics; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Theobromine; Theophylline | 1985 |
Fatigue in frog skeletal muscle fibres and effects of methylxanthine derivatives.
Topics: Animals; Caffeine; Diethylstilbestrol; Electric Stimulation; Muscle Contraction; Muscles; Rana temporaria; Theophylline | 1985 |
A survey of caffeine measurements in routine samples submitted for theophylline assay.
Topics: Caffeine; Chromatography; Humans; Immunologic Techniques; Infant, Newborn; Infant, Premature; Middle Aged; Theophylline | 1985 |
Direct determination of theophylline in serum by fluoroimmunoassay using highly specific antibodies.
Topics: Animals; Antibody Specificity; Caffeine; Cross Reactions; Female; Fluorescein; Fluoresceins; Fluorescent Antibody Technique; Humans; Rabbits; Sheep; Theobromine; Theophylline; Xanthines | 1985 |
Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression.
Topics: Acute Disease; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Inversion; Chromosomes, Human, 16-18; DNA Repair; DNA, Neoplasm; Humans; Leukemia; Theophylline; X Chromosome | 1986 |
Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Coffee; Female; Humans; Male; Tea; Theobromine; Theophylline; Xanthines | 1986 |
Comparison between theophylline analysis by nephelometric inhibition immunoassay and high performance liquid chromatography.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoassay; Nephelometry and Turbidimetry; Theophylline | 1986 |
Caffeine no longer measurable with theophylline channel of the TDx.
Topics: Autoanalysis; Caffeine; Cross Reactions; Humans; Theophylline | 1985 |
Discriminative stimulus properties of methylxanthines and their metabolites in rats.
Topics: Animals; Caffeine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1985 |
Use of microbore high-performance liquid chromatography for the determination of caffeine, theobromine and theophylline in cocoa.
Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Theobromine; Theophylline | 1985 |
Prediction of xanthine solubilities using statistical techniques.
Topics: Caffeine; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Solubility; Solvents; Statistics as Topic; Theobromine; Theophylline; Xanthines | 1985 |
High-performance liquid chromatographic determination of dimethylxanthine metabolites of caffeine in human plasma.
Topics: Ammonium Sulfate; Caffeine; Chromatography, High Pressure Liquid; Humans; Liver Diseases; Theobromine; Theophylline | 1985 |
[Determination of theophylline and caffeine in blood serum by thin-layer chromatography-densitometry].
Topics: Caffeine; Chromatography, Thin Layer; Densitometry; Evaluation Studies as Topic; Female; Fetal Blood; Humans; Pregnancy; Theophylline | 1985 |
The fate of chronically consumed caffeine in the monkey (Macaca fascicularis).
Topics: Animals; Biotransformation; Body Weight; Caffeine; Chromatography, High Pressure Liquid; Eating; Female; Macaca fascicularis; Milk; Theobromine; Theophylline; Time Factors | 1985 |
Theophylline and fibrocystic breast disease.
Topics: Adult; Age Factors; Asthma; Caffeine; Estrogens; Female; Fibrocystic Breast Disease; Humans; Menopause; Middle Aged; Pregnancy; Risk; Theophylline; Xanthines | 1985 |
The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats.
Topics: Administration, Oral; Animals; Caffeine; Female; Injections, Intravenous; Kinetics; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1985 |
Sensitivity of inbred mice to methylxanthines is not determined by plasma xanthine concentration.
Topics: Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Motor Activity; Species Specificity; Theophylline; Xanthine; Xanthines | 1985 |
HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guarana) and Cola spp. samples.
Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Coffee; Plants; Plants, Medicinal; Theophylline | 1985 |
High performance liquid chromatographic procedure for the simultaneous determination of theophylline, caffeine, and phenobarbital in neonates.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Phenobarbital; Spectrophotometry, Ultraviolet; Theophylline | 1985 |
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine.
Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1985 |
Improved high-performance liquid chromatographic method for the simultaneous determination of caffeine and its N-demethylated metabolites in plasma using solid-phase extraction.
Topics: Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Humans; Serum Albumin, Bovine; Theobromine; Theophylline; Xanthines | 1985 |
Studies on methyl-xanthines in intact and hypophysectomised rats: differences in pharmacokinetics and adrenocortical response.
Topics: Adrenal Cortex; Animals; Blood Proteins; Caffeine; Corticosterone; Half-Life; Hematocrit; Hypophysectomy; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1985 |
Drug discrimination and cross generalization between two methylxanthines.
Topics: Amphetamine; Animals; Caffeine; Discrimination, Psychological; Generalization, Psychological; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Theophylline | 1985 |
Caffeine citrate: an alternative to theophylline for apnea in prematurity.
Topics: Apnea; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Theophylline | 1985 |
Two high-performance liquid chromatographic methods for quantitation of theophylline in plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1985 |
Caffeine interference with the CANAM-theophylline reagent kit.
Topics: Caffeine; Cross Reactions; Humans; Reagent Kits, Diagnostic; Theophylline | 1985 |
Caffeine disposition after oral administration to pregnant rats.
Topics: Administration, Oral; Amniotic Fluid; Animals; Caffeine; Female; Fetus; Pregnancy; Rats; Theobromine; Theophylline; Time Factors | 1985 |
[Determination of caffeine and dimethylxanthines in biological fluids and tissues by high performance liquid chromatography].
Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy; Rats; Theophylline; Tissue Distribution | 1985 |
Correlations between electrical and pharmacological observations during anoxia in the rabbit, in normal and assisted respiration.
Topics: Amphetamine; Brain; Caffeine; Electroencephalography; Ethylamines; Hypoxia; Meclofenoxate; Methylphenidate; Pentylenetetrazole; Respiration; Respiration, Artificial; Theophylline | 1971 |
Cyclic AMP and immune responses. II. Phosphodiesterase inhibitors as potentiators of polynucleotide effects on antibody formation.
Topics: Animals; Antibodies; Antibody Formation; Antibody-Producing Cells; Antigens; Caffeine; Culture Techniques; Cyclic AMP; Erythrocytes; Female; gamma-Globulins; Hemagglutination Tests; Hemolytic Plaque Technique; Mice; Phosphoric Monoester Hydrolases; Poly I-C; Polynucleotides; Sheep; Spleen; Theophylline; Tuberculin | 1971 |
Effect of caffeine and theophylline on Mg ++ -dependent ATPase.
Topics: Adenosine Triphosphatases; Caffeine; Cyclic AMP; Drug Synergism; Enzyme Activation; Erythrocytes; Humans; Magnesium; Membranes; Oxytocin; Saponins; Theophylline | 1972 |
Synergistic effect of methyl-substituted xanthines and neomycin sulphate on Staphylococcus aureus and Pseudomonas aeruginosa in vitro.
Topics: Caffeine; Drug Resistance, Microbial; Drug Synergism; Neomycin; Pseudomonas aeruginosa; Staphylococcus; Theophylline | 1973 |
Relaxation of catch in a molluscan smooth muscle. I. Effects of drugs which act on the adenyl cyclase system.
Topics: Acetylcholine; Adenine Nucleotides; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antimetabolites; Azides; Bivalvia; Butyrates; Caffeine; Cyanides; Cyclic AMP; Fluorides; Isoproterenol; Muscle Contraction; Muscle, Smooth; Neuromuscular Nondepolarizing Agents; Nicotinic Acids; Seawater; Serotonin; Temperature; Theophylline; Time Factors | 1972 |
Influence of methylxanthines and local anaesthetics on the metabolism of muscle and associated changes in mitochondrial morphology.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acids; Anesthetics, Local; Animals; Caffeine; Caprylates; Carbon Isotopes; Cyclic AMP; Diaphragm; Epinephrine; In Vitro Techniques; Lactates; Microscopy; Microscopy, Electron; Mitochondria, Muscle; Muscles; Oxygen Consumption; Protein Biosynthesis; Rats; Theophylline; Transfer RNA Aminoacylation; Xanthines | 1973 |
Evaluation of electrical pulses and elevated levels of potassium ions as stimulants of adenosine 3', 5'-monophosphate (cyclic AMP) accumulation in guinea-pig brain.
Topics: Adrenergic beta-Antagonists; Animals; Brain; Caffeine; Calcium; Cerebellum; Cerebral Cortex; Cyclic AMP; Diphenhydramine; Electric Stimulation; Electrodes; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Norepinephrine; Phosphodiesterase Inhibitors; Potassium; Prostaglandins; Reserpine; Stimulation, Chemical; Theophylline; Xanthenes | 1973 |
Increased synthesis of adrenomedullary catecholamines induced by caffeine and theophylline.
Topics: Adrenal Glands; Animals; Caffeine; Cordotomy; Dopamine; Enzyme Induction; Epinephrine; Male; Norepinephrine; Rats; Spinal Cord; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase | 1974 |
Relation of the second messenger system to the electrogenesis and regulation of the contraction in the heart cell membrane of insecta.
Topics: Action Potentials; Adenylyl Cyclases; Animals; Bucladesine; Caffeine; Cyclic AMP; Electric Stimulation; Enzyme Activation; Fluorides; Grasshoppers; Heart; Heart Rate; Imidazoles; Microelectrodes; Myocardium; Oscillometry; Phosphodiesterase Inhibitors; Serotonin; Theophylline; Time Factors | 1974 |
Intracellular actions of 5-hydroxytryptamine on the bivalve myocardium. 1. Adenylate and guanylate cyclases.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Bivalvia; Bucladesine; Caffeine; Cyclic AMP; Cyclic GMP; Dopamine; Guanylate Cyclase; Heart; Myocardium; Protein Binding; Serotonin; Stimulation, Chemical; Temperature; Theophylline; Tritium | 1974 |
[Studies on the effect of various substances on platelet function with several methods].
Topics: Amphetamine; Anti-Anxiety Agents; Blood Platelets; Caffeine; Chlorpromazine; Debrisoquin; Dibenzazepines; Flurazepam; Guanethidine; Humans; Oxazoles; Papaverine; Phenytoin; Platelet Aggregation; Pyridines; Theophylline | 1973 |
[Management of heart and circulation. 1. Circulatory agents].
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Cardiovascular Diseases; Peptides; Theophylline; Vasoconstrictor Agents | 1973 |
[Action of electric stimulation of the brachial plexus on the potential difference of isolated frog skin].
Topics: Acetazolamide; Acetylcholine; Animals; Anura; Brachial Plexus; Caffeine; Carbachol; Cell Membrane Permeability; Cocaine; Curare; Dinitrophenols; Electric Stimulation; Epithelial Cells; In Vitro Techniques; Neuromuscular Junction; Norepinephrine; Papaverine; Pilocarpine; Skin; Theophylline | 1964 |
A failure of specific inhibitors to affect survival of Chinese hamster cells exposed to ultra-violet light.
Topics: Acridines; Animals; Caffeine; Chloramphenicol; Clone Cells; Cricetinae; Cycloheximide; Dactinomycin; Puromycin; Radiation Effects; Theophylline; Ultraviolet Rays | 1967 |
The methyl xanthines--a new class of goitrogens.
Topics: Aminophylline; Animals; Antithyroid Agents; Blood Proteins; Caffeine; Cyclic AMP; Drug Synergism; Goiter; Hypophysectomy; In Vitro Techniques; Iodine; Male; Propylthiouracil; Protein Binding; Rats; Theobromine; Theophylline; Thyroid Gland | 1969 |
The inhibition of allergic reactions by sympathomimetic amines and methylxanthines.
Topics: Animals; Antigens; Caffeine; Cyclic AMP; Guinea Pigs; Histamine Release; Humans; Hypersensitivity; Isoproterenol; Lung; Theophylline | 1970 |
Properties of glycogen synthetase in erythrocytes.
Topics: Adenosine Triphosphate; Caffeine; Erythrocytes; Galactose; Glucosephosphates; Glucosyltransferases; Glycogen; Glycogen Synthase; Hemolysis; Hexosephosphates; Hot Temperature; Humans; Kinetics; Phosphates; Protein Denaturation; Sulfates; Theophylline; Uridine Diphosphate Sugars | 1972 |
Repression of alkaline phosphatase synthesis by adenine, adenosine and adenine nucleotides in an adenine auxotroph of Bacillus anthracis.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Alkaline Phosphatase; Bacillus anthracis; Caffeine; Chlorpromazine; Culture Media; Dinitrophenols; Enzyme Repression; Inosine Nucleotides; Lyases; Mutation; Phosphates; Theophylline | 1973 |
Platelets and clot retraction. Effect of divalent cations and several drugs.
Topics: Adenosine Diphosphate; Blood Platelets; Caffeine; Calcium Chloride; Chlorides; Clot Retraction; Edetic Acid; Epinephrine; Ethylenes; Glycols; Magnesium; Manganese; Muscle, Smooth; Norepinephrine; Theophylline; Thrombelastography | 1973 |
A systematic study of variables affecting protein binding of thyroxine and triiodothyronine in serum.
Topics: Anions; Barbiturates; Buffers; Caffeine; Depression, Chemical; Dialysis; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Methimazole; Osmolar Concentration; Phenytoin; Protein Binding; Salicylates; Temperature; Theophylline; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Ultrafiltration | 1974 |
[Do correlations exist between coffee drinking and myocardial infarction? (author's transl)].
Topics: Adolescent; Adult; Aged; Caffeine; Coffee; Female; Food Preferences; Germany, West; Health Surveys; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Tea; Theophylline | 1974 |
Spectrophotometric determination of plasma pyridones in man following nicotinamide administration, with a general note on the quantitative treatment of interfering substances in analytical methods.
Topics: Caffeine; Humans; Niacinamide; Pyridones; Spectrophotometry; Theophylline | 1966 |
[Influence of reserpine, propranolol, hexamethonium and adrenalectomy on the chronotropic actions of theophylline and caffeine].
Topics: Animals; Atrial Function; Caffeine; Depression, Chemical; Heart Atria; Heart Rate; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Propranolol; Rats; Reserpine; Tachycardia; Theophylline | 1968 |
Studies on complexes. 13. Effect of complex formation on drug absorption from alimentary tract. (4).
Topics: Aminosalicylic Acids; Animals; Caffeine; Drug Compounding; Intestinal Absorption; Intestine, Small; Kinetics; Niacinamide; Oxazoles; Pyridazines; Rats; Theophylline | 1968 |
[The participation of endogenous catecholamines in the pharmacological effects of theophylline and caffeine].
Topics: Animals; Caffeine; Catecholamines; Hexamethonium Compounds; Propranolol; Rats; Reserpine; Theophylline | 1968 |
Studies on complexes. XIV. Effect of complex formation on drug absorption from alimentary tract. (5). Enhancing the absorption of certain drugs by complex formation.
Topics: Animals; Antipyrine; Caffeine; Indoles; Intestinal Absorption; Intestine, Small; Niacinamide; Rats; Salicylates; Theophylline | 1969 |
Studies on complexes. XVI. Effect of complex formation on drug absorption from alimentary tract. (6). Some factors affecting complex absorption.
Topics: Aminosalicylic Acids; Animals; Caffeine; Drug Synergism; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Niacinamide; Perfusion; Rats; Stimulation, Chemical; Theophylline | 1969 |
The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.
Topics: Adenosine Triphosphatases; Aminophylline; Anesthetics, Local; Animals; Biological Transport, Active; Caffeine; Calcium; Cell Membrane Permeability; Endoplasmic Reticulum; Hot Temperature; Lidocaine; Muscles; Procaine; Rabbits; Tetracaine; Theophylline; Veratrine; Xanthines | 1969 |
[Chronotropic and metabolic effects of theophylline and caffeine in euthyroid, hyperthyroid and athyroid rats].
Topics: Animals; Caffeine; Fatty Acids, Nonesterified; Hyperthyroidism; Male; Oxygen Consumption; Rats; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyroidectomy | 1969 |
Prevention of the negative chronotropic effect of adenosine by caffeine.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphatases; Animals; Caffeine; Dogs; Methods; Nucleosides; Sinoatrial Node; Theophylline; Vagotomy | 1969 |
Studies on complexes. XX. Effect of complex formation on drug absorption from alimentary tract.
Topics: Adrenochrome; Animals; Caffeine; Chelating Agents; Gastric Mucosa; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Male; Niacinamide; Rats; Theophylline | 1970 |
[Influence of thyroid gland function on the chronotropic and some metabolic actions of theophylline and caffeine].
Topics: Adenylyl Cyclases; Adrenal Medulla; Animals; Blood Glucose; Caffeine; Enzyme Activation; Fatty Acids, Nonesterified; Heart Rate; Hyperthyroidism; Hypothyroidism; Male; Oxygen Consumption; Rats; Reserpine; Stimulation, Chemical; Theophylline; Triiodothyronine | 1970 |
Proceedings: Prevention by Ca-antagonistic compounds (verapamil, D 600) of coronary smooth muscle contractures due to treatment with cardiac glycosides.
Topics: Animals; Caffeine; Calcium; Cardiac Glycosides; Coronary Vessels; Dipyridamole; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prenylamine; Theophylline; Verapamil | 1974 |
A possible role for the adenylcyclase system in insulin secretion.
Topics: Adrenocorticotropic Hormone; Animals; Caffeine; Glucagon; Insulin; Isoproterenol; Oxytocin; Phenoxybenzamine; Rats; Sympathomimetics; Theophylline; Thyrotropin; Vasopressins | 1967 |
Comparisons of the effects of Bacillus subtilis protease, type VIII (subtilopeptidase A), and insulin on isolated adipose cells. II. Antilipolytic action.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bacillus subtilis; Caffeine; Carbon Isotopes; Depression, Chemical; Endopeptidases; Epididymis; Fatty Acids, Nonesterified; Glucose; Glycerol; Insulin; Lipid Metabolism; Male; Norepinephrine; Rats; Spectrophotometry; Stimulation, Chemical; Theophylline | 1968 |
A rapid micro-method for the separation, identification and estimation of the purine bases: caffeine, theobromine and theophylline.
Topics: Caffeine; Chromatography, Thin Layer; Methods; Silicon Dioxide; Theobromine; Theophylline | 1968 |
Effects of piercidin A on the metabolism of isolated adipose cells.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Caffeine; Carbon Isotopes; Depression, Chemical; Epididymis; Fatty Acids; Fructose; Glucose; Glycerol; Glycogen; Insulin; Lipid Metabolism; Male; Norepinephrine; Oxidation-Reduction; Palmitic Acids; Peptide Hydrolases; Rats; Stimulation, Chemical; Theophylline; Ubiquinone | 1968 |
Effects of avenaciolide on lipolysis and on glucose, amino acid and palmitic acid metabolism in isolated adipose cells.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Antifungal Agents; Aspergillus; Caffeine; Carbon Isotopes; Epididymis; Glucose; Insulin Antagonists; Lactones; Lipid Metabolism; Male; Norepinephrine; Oxidation-Reduction; Palmitic Acids; Rats; Theophylline | 1968 |
Controle of the metabolism and lipolytic effects of cyclic 3',5'-adenosine monophosphate in adipose tissue by insulin, methyl xanthines, and nicotinic acid.
Topics: Adenine Nucleotides; Adipose Tissue; Animals; Blood Glucose; Caffeine; Cyclic AMP; Depression, Chemical; Diabetes Mellitus, Experimental; Epididymis; Hyperinsulinism; Insulin; Kinetics; Lipid Metabolism; Male; Nicotinic Acids; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline | 1968 |
Antilipolytic acition of valinomycin and nonactin in isolated adipose cells through inhibition of adenyl cyclase.
Topics: Adenine; Adenine Nucleotides; Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Caffeine; Carbon Isotopes; Enzyme Inhibitors; Male; Norepinephrine; Rats; Theophylline; Tyrothricin | 1968 |
Stimulation of glucose utilization and inhibition of lipolysis by polyene antibiotics in isolated adipose cells.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Alkenes; Animals; Anti-Bacterial Agents; Antifungal Agents; Caffeine; Carbon Isotopes; Depression, Chemical; Drug Synergism; Epididymis; Glucose; Hexoses; Insulin; Lipid Metabolism; Lipoproteins; Male; Membranes; Natamycin; Norepinephrine; Nystatin; Peptide Hydrolases; Phlorhizin; Phospholipases; Puromycin; Rats; Stimulation, Chemical; Theophylline | 1968 |
The interconversion of liver glycogen synthetase a and b in vitro.
Topics: Adenosine Triphosphate; Animals; Caffeine; Cyclic AMP; Edetic Acid; Fluorides; Glycogen; In Vitro Techniques; Ligases; Liver; Liver Glycogen; Magnesium; Male; Mice; Phosphates; Prednisolone; Sulfates; Theophylline; Xanthines | 1968 |
[Inhibition of lipolysis in adipose tissue by methylisoxazolcarboxylic acids].
Topics: Adipose Tissue; Animals; Antimetabolites; Caffeine; Carbon Isotopes; Cyclic AMP; Depression, Chemical; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hypolipidemic Agents; Male; Oxazoles; Phosphoric Monoester Hydrolases; Rats; Theophylline; Triglycerides | 1968 |
Adenyl cyclase activity in the rabbit ovary.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Carbon Isotopes; Chorionic Gonadotropin; Chromatography, Thin Layer; Cyclic AMP; Enzymes; Female; Fluorides; Follicle Stimulating Hormone; In Vitro Techniques; Luteinizing Hormone; Methods; Ovary; Phosphoric Monoester Hydrolases; Pregnancy; Pseudopregnancy; Rabbits; Sodium; Stimulation, Chemical; Theophylline; Tritium | 1969 |
A comparison of the in-vitro actions of thyroid-stimulating hormone and cyclic 3',5'-adenosine monophosphate on the mouse thyroid gland.
Topics: Adenine Nucleotides; Animals; Caffeine; Chromatography, Paper; Cyclic AMP; Drug Synergism; In Vitro Techniques; Iodine Isotopes; Mice; Theophylline; Thyroid Gland; Thyrotropin; Tissue Extracts | 1969 |
Studies on the action of insulin in isolated adipose tissue cells. II. 3',5'-Nucleotide phosphodiesterase and antilipolysis.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Corynebacterium diphtheriae; Cyclic AMP; Depression, Chemical; Epididymis; Epinephrine; Glucagon; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Insulin; Kinetics; Lipid Metabolism; Male; Membranes; Nicotinic Acids; Nucleotides; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline; Ultrasonics | 1969 |
Proteolysis in thyroid slices: Effects of TSH, dibutyryl cyclic 3', 5'-AMP and prostaglandin E.
Topics: Adenine Nucleotides; Animals; Caffeine; Chromatography, Paper; Cyclic AMP; Diiodotyrosine; Dogs; Epinephrine; Fluorides; In Vitro Techniques; Iodine; Iodine Isotopes; Iodoproteins; Male; Monoiodotyrosine; Prostaglandins; Proteins; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyrotropin | 1970 |
Dissociation of lipolysis and protein anabolism by ACTH, bovine growth hormone, and thyroid stimulating hormone in adipose tissue with dibutyryl cyclic AMP and theophylline.
Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Butyrates; Caffeine; Carbon Isotopes; Cyclic AMP; Epididymis; Glycerol; Growth Hormone; Histidine; Lipid Metabolism; Male; Metabolism; Protein Biosynthesis; Rats; Theophylline; Thyrotropin | 1970 |
Regulation of skeletal muscle phosphorylase phosphatase activity. I. Kinetic properties of the active and inactive forms.
Topics: Adenine Nucleotides; Animals; Caffeine; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Diphosphates; Enzyme Activation; Glucosyltransferases; Guanine Nucleotides; Hydrogen-Ion Concentration; Kinetics; Muscles; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Rabbits; Theophylline; Uracil Nucleotides | 1970 |
The metabolism of adenosine 3',5'-cyclic phosphate. II. Some properties of adenosine-3',5'-cyclic-phosphate phosphodiesterase from the rat kidney.
Topics: 1-Propanol; Adenosine Triphosphate; Alcohols; Animals; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Paper; Cyclic AMP; Fluorides; Hydrogen-Ion Concentration; Kidney; Kinetics; Magnesium; Nucleotides; Phosphoric Monoester Hydrolases; Quaternary Ammonium Compounds; Rats; Solvents; Theophylline; Water; Xanthines | 1970 |
The stimulatory effect of luteinizing hormone on adenyl cyclase in the bovine corpus luteum.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Carbon Isotopes; Cattle; Corpus Luteum; Cyclic AMP; Depression, Chemical; Enzymes; Epinephrine; Female; Fluorides; Glucagon; Hydrogen Peroxide; Luteinizing Hormone; Metabolism; Phosphoric Monoester Hydrolases; Pregnancy; Prolactin; Serum Albumin, Bovine; Stimulation, Chemical; Theophylline; Time Factors; Tritium | 1970 |
[Antagonism of circulation effect of adenosine by theophylline].
Topics: Adenine Nucleotides; Aminophylline; Animals; Arteries; Blood Circulation; Blood Platelets; Blood Pressure; Bradycardia; Caffeine; Cell Aggregation; Coronary Vessels; Cyclic AMP; Depression, Chemical; Dogs; Guinea Pigs; Heart Arrest; Heart Rate; In Vitro Techniques; Nucleosides; Rabbits; Rats; Regional Blood Flow; Stimulation, Chemical; Theophylline; Vasodilator Agents | 1970 |
[Hormone sensitive lipase].
Topics: Adenine Nucleotides; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Enzyme Activation; Epididymis; Epinephrine; Fasting; Growth Hormone; Heparin; Hydrogen-Ion Concentration; In Vitro Techniques; Lipase; Lipoprotein Lipase; Male; Norepinephrine; Rats; Reserpine; Theophylline | 1970 |
The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands.
Topics: Animals; Caffeine; Cyclic AMP; Diptera; Salivary Glands; Serotonin; Theophylline | 1970 |
Adenosine 3',5'-monophosphate phosphodiesterase in the growth medium of Physarum polycephalum.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Caffeine; Chromatography, Paper; Culture Media; Hydrogen-Ion Concentration; Kinetics; Myxomycetes; Phosphoric Monoester Hydrolases; Theophylline | 1971 |
Adenosine 3',5'-cyclic phosphate phosphodiesterase of corpus luteum.
Topics: Animals; Caffeine; Cattle; Corpus Luteum; Cyclic AMP; Estrus; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Phosphoric Monoester Hydrolases; Pregnancy; Rats; Theophylline | 1971 |
Sodium and water movement across the urinary bladder of a urodele amphibian (th mudpuppy Necturus maculosus): studies and vasotocin and aldosterone.
Topics: Aldosterone; Amphotericin B; Animals; Anura; Biological Transport; Caffeine; Cyclic AMP; Diuretics; In Vitro Techniques; Membrane Potentials; Ouabain; Peptides; Physiology, Comparative; Pituitary Hormones, Posterior; Pyrazines; Seasons; Sodium; Theophylline; Urinary Bladder; Urodela; Vasotocin; Water | 1971 |
ACTH secretion due to hypothalamo-pituitary effects of adenosine 3',5'-monophosphate and related substances.
Topics: Adenine Nucleotides; Adrenocorticotropic Hormone; Animals; Caffeine; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP; Dexamethasone; Female; Hypothalamo-Hypophyseal System; Pituitary Gland; Rats; Stimulation, Chemical; Theophylline | 1971 |
Uptake and release of 45Ca by brain microsomes, synaptosomes and synaptic vesicles.
Topics: Adenosine Monophosphate; Adenosine Triphosphatases; Animals; Axons; Biological Transport, Active; Brain; Caffeine; Calcium; Calcium Isotopes; Cell Membrane; Choline; Cyclic AMP; In Vitro Techniques; Magnesium; Microsomes; Mitochondria; Potassium Chloride; Rats; Sodium Chloride; Sucrose; Synaptic Vesicles; Theophylline; Xanthines | 1971 |
Effects of phosphodiesterase inhibitors on cyclic AMP levels and on lipolysis.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Depression, Chemical; In Vitro Techniques; Lipid Metabolism; Lipid Mobilization; Liver; Myocardium; Papaverine; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline; Xanthines | 1971 |
On the role of cyclic AMP in insulin release: I. Overall effects in cultured fetal rat pancreas.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Cyclic AMP; Fetus; Glucose; Hexoses; Insulin; Insulin Secretion; Islets of Langerhans; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pyruvates; Rats; Theophylline; Tolbutamide | 1971 |
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans.
Topics: Animals; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Theophylline; Xanthines | 1971 |
Antibody formation: reduced responses after administration of excessive amounts of nonspecific stimulators.
Topics: Animals; Antibody Formation; Antigens; Caffeine; Cells, Cultured; Cyclic AMP; Erythrocytes; Injections, Intraperitoneal; Injections, Intravenous; Mice; Polynucleotides; Sheep; Spleen; Stimulation, Chemical; Theophylline | 1971 |
Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines.
Topics: Animals; Caffeine; Calcium; Carbon Isotopes; Cattle; Cholecystokinin; Cyclic AMP; Drug Synergism; Epinephrine; Fasting; Fluorides; Glucagon; Gluconeogenesis; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; Isoproterenol; Kinetics; Lactates; Liver; Male; Nicotinic Acids; Norepinephrine; Perfusion; Prostaglandins; Rats; Rats, Inbred Strains; Secretin; Serotonin; Theophylline | 1971 |
The determination of nikethamide and other compounds in pharmaceutical dosage forms by thin-layer chromatography.
Topics: Adenosine; Caffeine; Chromatography, Thin Layer; Dosage Forms; Gels; Methods; Niacinamide; Silicon Dioxide; Solvents; Spectrophotometry; Strychnine; Theophylline; Ultraviolet Rays | 1971 |
The effect of dihydroergotamine on the phosphodiesterase activity of cat grey matter.
Topics: Animals; Brain; Caffeine; Cats; Chromatography; Cyclic AMP; Ergotamine; Papaverine; Phosphoric Monoester Hydrolases; Theophylline | 1971 |
Cyclic nucleotide phosphodiesterase: high activity in a mammalian photoreceptor.
Topics: Animals; Brain; Butyrates; Caffeine; Cattle; Centrifugation, Density Gradient; Chickens; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Hydrolysis; Kinetics; Papaverine; Phosphoric Monoester Hydrolases; Photoreceptor Cells; Rats; Retina; Theophylline; Uracil Nucleotides | 1972 |
Role of cyclic 3',5'-amp in the action of physiological secretagogues on the metabolism of rat pancreas in vitro.
Topics: Animals; Butyrates; Caffeine; Carbamates; Carbon Isotopes; Cholecystokinin; Choline; Chymotrypsinogen; Cyclic AMP; Glucose; In Vitro Techniques; Lactates; Leucine; Lipase; Pancreas; Phosphates; Phosphatidylinositols; Phospholipids; Phosphorus Isotopes; Protein Biosynthesis; Rats; Theophylline; Tritium | 1971 |
The effect of cyclic adenosine 3',5' monophosphate, methyl xanthines and nicotinic acid on plasma nonesterified fatty acids in sheep.
Topics: Animals; Blood Glucose; Caffeine; Cyclic AMP; Fatty Acids, Nonesterified; Female; Glycogen Storage Disease; Glycolysis; Injections, Intravenous; Nicotinic Acids; Sheep; Theophylline | 1971 |
The stimulating action of gastrin pentapeptide and histamine on adenyl cyclase activity in rat stomach.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Autoradiography; Caffeine; Carbon Isotopes; Cyclic AMP; Enzyme Activation; Gastrins; Histamine; Male; Peptides; Rats; Stimulation, Chemical; Stomach; Theophylline | 1971 |
Comparison of the phosphodiesterases in the submaxillary gland, brain and liver.
Topics: Animals; Brain; Caffeine; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Liver; Papaverine; Phosphoric Monoester Hydrolases; Submandibular Gland; Theophylline | 1972 |
Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.
Topics: Adenine; Caffeine; Cyclic AMP; Epinephrine; Guanine; Guanosine; Humans; Hypoxanthines; Imidazoles; Leukocytes; Movement; Purines; Pyrimidines; Reserpine; Structure-Activity Relationship; Theophylline; Thymine; Uracil; Uric Acid; Xanthines | 1972 |
[Action of phosphodiesterase inhibitors on electric discharge of the electroplax isolated from Electrophorus electricus (L.)].
Topics: Action Potentials; Animals; Caffeine; Cyclic AMP; Electric Organ; Electric Stimulation; Fishes; Phosphoric Monoester Hydrolases; Theophylline; Time Factors | 1972 |
The actions of dibutyryl cyclic adenosine 3',5'-monophosphate and methyl xanthines on pancreatic exocrine secretion.
Topics: Animals; Caffeine; Cats; Cholecystokinin; Cyclic AMP; Drug Synergism; In Vitro Techniques; Pancreas; Pancreatic Juice; Secretin; Stimulation, Chemical; Theobromine; Theophylline; Water; Xanthines | 1972 |
[Inhibition of adenyl cyclase preparations from rat kidney by calcium ions and various diuretics].
Topics: Adenylyl Cyclase Inhibitors; Animals; Caffeine; Calcitonin; Calcium; Carbon Isotopes; Cyclic AMP; Depression, Chemical; Dithiothreitol; Diuretics; Ethacrynic Acid; In Vitro Techniques; Kidney; Magnesium; Male; Manganese; Organomercury Compounds; Parathyroid Hormone; Rats; Theophylline; Vasopressins | 1972 |
[Demonstration of 3'5'-cyclic AMP phosphodiesterase activity in the human placenta at term].
Topics: Caffeine; Cyclic AMP; Epinephrine; Female; Fluorides; Humans; Imidazoles; Luteinizing Hormone; Norepinephrine; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Placenta; Pregnancy; Sodium; Theophylline; Time Factors; Tritium | 1972 |
Cyclic 3',5'-AMP phosphodiesterase in isolated fat cells. Simple and sensitive methods for the assay of phosphodiesterase activity in fat cells and studies of the enzyme inhibition by theophylline.
Topics: Adipose Tissue; Animals; Brain; Caffeine; Chromatography, Ion Exchange; Cyclic AMP; Kinetics; Male; Methods; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Rats; Spectrophotometry; Theophylline; Time Factors | 1972 |
Cyclic 3',5'-AMP phosphodiesterase of human blood lymphocytes.
Topics: Caffeine; Calcium; Chloromercuribenzoates; Cold Temperature; Cyclic AMP; Dithiothreitol; Drug Stability; Endotoxins; Humans; Hydrogen-Ion Concentration; Kinetics; Lectins; Lipopolysaccharides; Lymphocytes; Magnesium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Salmonella typhi; Streptolysins; Subcellular Fractions; Theophylline; Time Factors | 1972 |
Cyclic-AMP in the aqueous humor: the effects of adrenergic agents.
Topics: Aminophylline; Animals; Aqueous Humor; Caffeine; Ciliary Body; Cornea; Cyclic AMP; Epinephrine; Intraocular Pressure; Iris; Isoproterenol; Male; Norepinephrine; Phenoxybenzamine; Propranolol; Rabbits; Retina; Stimulation, Chemical; Sympatholytics; Sympathomimetics; Theophylline | 1972 |
Calcium current channels induced by catecholamines in chick embryonic hearts whose fast sodium channels are blocked by tetrodotoxin or elevated potassium.
Topics: Acetylcholine; Age Factors; Animals; Caffeine; Calcium; Catecholamines; Chick Embryo; Cyclic AMP; Epinephrine; Heart; In Vitro Techniques; Isoproterenol; Lanthanum; Microelectrodes; Myocardium; Norepinephrine; Phenylalanine; Potassium; Prostaglandins; Sodium; Structure-Activity Relationship; Tetrodotoxin; Theophylline; Time Factors | 1972 |
The development of lipolytic sensitivity in the isolated fat cells of Gallus domesticus during the foetal and neonatal period.
Topics: Adipose Tissue; Age Factors; Animals; Animals, Newborn; Caffeine; Chick Embryo; Chickens; Cyclic AMP; Drug Interactions; Glucagon; Lipid Metabolism; Norepinephrine; Phosphoric Diester Hydrolases; Theophylline | 1972 |
[Role of cyclic AMP in neuromuscular transmission--with special reference to the effect of catecholamines, xanthines and calcium on myasthenic syndrome].
Topics: Caffeine; Calcium; Catecholamines; Cyclic AMP; Depression, Chemical; Epinephrine; Evoked Potentials; Humans; Myasthenia Gravis; Neuromuscular Junction; Synaptic Transmission; Theophylline; Xanthines | 1972 |
1-Ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)--a potent new inhibitor of cyclic 3',5'-nucleotide phosphodiesterases.
Topics: Adrenal Glands; Ammonium Sulfate; Animals; Brain; Caffeine; Carboxylic Acids; Cats; Cattle; Cyclic AMP; Cyclic GMP; Esters; Hydrazines; Hydrolysis; In Vitro Techniques; Kinetics; Male; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Rats; Theophylline | 1972 |
Adenine nucleotide mediation of fructolysis and motility in bovine epididymal spermatozoa.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Butyrates; Caffeine; Carbon Isotopes; Cattle; Cell Movement; Cyclic AMP; Epididymis; Fructose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; In Vitro Techniques; Kinetics; Lactates; Male; Microscopy, Phase-Contrast; Nucleotides; Phosphodiesterase Inhibitors; Spermatozoa; Theophylline | 1973 |
Metabolism of adenosine 3',5'-cyclic monophosphate and induction of fruiting bodies in Coprinus macrorhizus.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclases; Basidiomycota; Caffeine; Cell-Free System; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic AMP; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spores, Fungal; Theophylline; Tritium | 1973 |
Cyclic adenosine 3',5'-monophosphate in the control of melanoma cell replication and differentiation.
Topics: Caffeine; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Dendrites; In Vitro Techniques; Melanins; Melanoma; Methods; Theophylline | 1973 |
Studies on phosphodiesterase from oxyntic cells of bullfrog gastric mucosa. I. Intracellular localization, partial purification, and properties.
Topics: Ammonium Sulfate; Animals; Anura; Caffeine; Chemical Phenomena; Chemistry; Choline; Cyclic AMP; Gastric Mucosa; Histamine; Hydrogen-Ion Concentration; Imipramine; In Vitro Techniques; Kinetics; Magnesium; Pentagastrin; Phosphoric Diester Hydrolases; Rana catesbeiana; Sulfhydryl Compounds; Theophylline; Time Factors; Tritium | 1973 |
Inhibition of cyclic 3',5'-nucleotide phosphodiesterase in bovine taste papillae by bitter taste stimuli.
Topics: Animals; Bacitracin; Binding, Competitive; Caffeine; Cattle; Cyclic AMP; Epithelium; In Vitro Techniques; Kinetics; Papaverine; Phosphodiesterase Inhibitors; Quinine; Strychnine; Taste; Taste Buds; Theobromine; Theophylline | 1972 |
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol | 1973 |
Cyclic AMP inhibition of cytotoxin ("lymphotoxin") elaboration by stimulated lymphocytes.
Topics: Butyrates; Caffeine; Cells, Cultured; Chromium Isotopes; Cyclic AMP; Cytotoxicity Tests, Immunologic; Humans; L Cells; Lectins; Lymphocytes; Theophylline | 1973 |
Inhibition and enhancement of the noradrenaline constrictor response by methylxanthines.
Topics: Animals; Caffeine; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Theobromine; Theophylline | 1973 |
Cyclic 3',5'-AMP phosphodiesterase of Neurospora crassa.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Caffeine; Cations, Divalent; Chromatography, Paper; Cyclic AMP; Edetic Acid; Histamine; Imidazoles; Kinetics; Neurospora; Neurospora crassa; Phosphates; Phosphoric Diester Hydrolases; Solubility; Theobromine; Theophylline; Time Factors; Tritium | 1973 |
Action of propranolol on lipolysis induced by catecholamine, dibutyryl cyclic AMP and serum.
Topics: Adipose Tissue; Animals; Bucladesine; Caffeine; Catecholamines; Cells; Epinephrine; Immune Sera; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Propranolol; Rats; Theophylline | 1973 |
Cyclic nucleotide phosphodiesterase from Tetrahymena.
Topics: Animals; Caffeine; Chromatography, Gel; Cyclic AMP; Drug Stability; Enzyme Activation; Imidazoles; Isoenzymes; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Tetrahymena; Theophylline; Time Factors; Tritium | 1973 |
Evidence for separate sites of action for the antilipolytic effects of insulin and prostaglandin E1.
Topics: Adipose Tissue; Animals; Bucladesine; Caffeine; Cyclic AMP; Insulin; Lipid Mobilization; Male; Phosphoric Diester Hydrolases; Prostaglandins; Rats; Theophylline | 1973 |
[Treatment and surveillance of severe chronic respiratory insufficiency].
Topics: Anti-Bacterial Agents; Breathing Exercises; Bronchodilator Agents; Caffeine; Chronic Disease; Expectorants; Glucocorticoids; Humans; Kyphosis; Lung Diseases, Obstructive; Oxygen Inhalation Therapy; Pneumoconiosis; Respiration, Artificial; Respiratory Insufficiency; Scoliosis; Theophylline | 1973 |
Effect of cyclic AMP, theophylline and caffeine on the glucose repression of sporulation in Saccharomyces cerevisiae.
Topics: Caffeine; Culture Media; Cyclic AMP; Drug Synergism; Glucose; Reproduction; Saccharomyces cerevisiae; Spectrophotometry; Spores, Fungal; Theophylline; Time Factors | 1973 |
Characteristics of cyclic 3',5'-nucleotide phosphodiesterase from the brain of the Madagascar cockroach (Gromphadorhina portentosa).
Topics: Adenosine Triphosphate; Animals; Brain; Caffeine; Cations, Divalent; Citrates; Cockroaches; Colorimetry; Cyclic AMP; Cyclic GMP; Diphosphates; Drug Stability; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnesium; Organ Specificity; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Reserpine; Temperature; Theophylline; Time Factors; Tritium; Xanthines | 1974 |
The effect of cytochalasin B on pigment dispersion and aggregation in perfused Xenopus laevis tailfin melanophores.
Topics: Animals; Bucladesine; Caffeine; Cell Aggregation; Chromatophores; Colchicine; Cyclic AMP; Cytochalasin B; Dimethyl Sulfoxide; Griseofulvin; Histocytochemistry; Larva; Melanins; Microtubules; Phosphodiesterase Inhibitors; Theophylline; Xenopus | 1974 |
Cyclic adenosine 3':5'-monophosphate and protein kinase levels in developing bovine spermatozoa.
Topics: Animals; Caffeine; Cattle; Cell Movement; Cyclic AMP; Epididymis; Male; Protein Kinases; Spermatogenesis; Spermatozoa; Theophylline | 1974 |
The mechanism of frog skin lightening by acetylcholine.
Topics: Acetylcholine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Anura; Caffeine; Cyclic AMP; In Vitro Techniques; Isoproterenol; Melanocyte-Stimulating Hormones; Melanocytes; Rana pipiens; Skin; Theophylline; Time Factors | 1974 |
ALA synthetase induction. Inhibitory effect exerted by administration of dibutyryl adenosine-3',5'-cyclic monophosphate, theophylline and caffeine.
Topics: 5-Aminolevulinate Synthetase; Adenosine Monophosphate; Animals; Bucladesine; Caffeine; Cyclic AMP; Depression, Chemical; Enzyme Induction; Female; Levulinic Acids; Liver; Rats; Theophylline; Time Factors | 1973 |
Cyclic AMP and platelet aggregation.
Topics: Adenosine Diphosphate; Caffeine; Collagen; Cyclic AMP; Densitometry; Depression, Chemical; Epinephrine; Glucagon; Humans; Imidazoles; In Vitro Techniques; Papaverine; Platelet Adhesiveness; Prostaglandins; Theophylline | 1972 |
Modulation by cyclic AMP in vitro of liver plasma membrane (Na+--K+)-ATPase and protein kinases.
Topics: Adenosine Triphosphatases; Animals; Bucladesine; Butyrates; Caffeine; Cell Membrane; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Cytosol; Epinephrine; Kinetics; Liver; Magnesium; Male; Nucleotides, Cyclic; Potassium; Propranolol; Protein Kinases; Sodium; Theophylline | 1974 |
Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii.
Topics: Aminophylline; Bucladesine; Caffeine; Cations, Divalent; Chlamydomonas; Chromatography, Thin Layer; Cyclic AMP; Cyclic GMP; Diphosphates; Drug Stability; Edetic Acid; Enzyme Activation; Hydrogen-Ion Concentration; Inosine Nucleotides; Kinetics; Nucleotides, Cyclic; Phosphates; Phosphoric Diester Hydrolases; Sulfhydryl Reagents; Temperature; Theophylline; Thymine Nucleotides; Time Factors; Tritium; Uracil Nucleotides | 1974 |
Effect of cyclic AMP, caffeine and theophylline on differentiation of lens epithelial cells.
Topics: Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Division; Cells, Cultured; Clone Cells; Crystallins; Drug Synergism; Lens, Crystalline; Rats; Stimulation, Chemical; Theophylline | 1974 |
Inhibition of 2-deoxy-D-glucose transport by theophylline, caffeine and papaverine in alveolar macrophages.
Topics: Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Kinetics; Macrophages; Papaverine; Prostaglandins; Pulmonary Alveoli; Sucrose; Theophylline; Tritium | 1974 |
Rod outer segment phosphodiesterase: factors affecting the hydrolysis of cyclic-AMP and cyclic-GMP.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Cattle; Cyclic AMP; Cyclic GMP; Dark Adaptation; Enzyme Activation; Freezing; Hot Temperature; Hydrolysis; In Vitro Techniques; Light; Magnesium; Manganese; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Photoreceptor Cells; Surface-Active Agents; Theophylline; Ultrasonics | 1974 |
Stimulation of sodium transport in turkey erythrocytes by cyclic 3',5'-AMP.
Topics: Adenylyl Cyclases; Animals; Biological Transport, Active; Bucladesine; Caffeine; Cell Membrane; Cyclic AMP; Enzyme Activation; Erythrocytes; Isoproterenol; Phosphoric Diester Hydrolases; Propranolol; Sodium; Theophylline; Time Factors; Tritium; Turkeys; Xanthines | 1974 |
The aggregation of rabbit polymorphonuclear leucocytes: effects of antimitotic agents, cyclic nucleotides and methyl xanthines.
Topics: Adenine; Adenosine; Animals; Bucladesine; Caffeine; Cell Aggregation; Colchicine; Cyclic AMP; Cyclic GMP; Depression, Chemical; In Vitro Techniques; Leukocytes; Nucleotides, Cyclic; Rabbits; Stimulation, Chemical; Theobromine; Theophylline; Vinblastine; Xanthines | 1974 |
Cyclic nucleotide phosphodiesterase in silkworm: purification and properties.
Topics: Animals; Bombyx; Caffeine; Cations, Divalent; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Edetic Acid; Electrophoresis, Disc; Fluorides; Hydrogen-Ion Concentration; Hydroxyapatites; Imidazoles; Kinetics; Larva; Molecular Weight; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature; Theophylline | 1974 |
Studies on lipolysis in lipid micelles isolated from adipose tissue.
Topics: Adenosine; Adenosine Monophosphate; Adipose Tissue; Animals; Bucladesine; Caffeine; Colloids; Cyclic AMP; Epididymis; Epinephrine; In Vitro Techniques; Lipid Metabolism; Macromolecular Substances; Male; Phospholipases; Rats; Theophylline | 1974 |
In vitro response of goldfish (Carassius auratus L.) dermal melanophores to cyclic 3',5'-nucleotides, nucleoside 5'-phosphates and methylxanthines.
Topics: Adenosine Monophosphate; Animals; Binding, Competitive; Bucladesine; Caffeine; Chromatophores; Cyclic AMP; Cyclic GMP; Cyprinidae; Cytosine Nucleotides; Goldfish; Guanine Nucleotides; Melanophores; Nucleotides; Nucleotides, Cyclic; Skin; Theophylline; Thymine Nucleotides; Time Factors; Uracil Nucleotides | 1974 |
Structure-activity relations for caffeine: a comparative study of the inotropic effects of the methylxanthines, imidazoles and related compounds on the frog's heart.
Topics: Adenosine; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Heart; Heart Atria; Histamine; Histidine; Hydrogen-Ion Concentration; Hypoxanthines; Imidazoles; In Vitro Techniques; Naphazoline; Phentolamine; Pilocarpine; Potassium; Pyridines; Rana pipiens; Solutions; Structure-Activity Relationship; Surface Tension; Theobromine; Theophylline; Tolazoline; Xanthines | 1974 |
The distribution, activity, and function of the cilia in the frog brain.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Brain; Caffeine; Cerebrospinal Fluid; Choroid Plexus; Cilia; Cyclic AMP; Depression, Chemical; Dinitrophenols; Ependyma; In Vitro Techniques; Iodoacetates; Ions; Microscopy, Electron, Scanning; Rana catesbeiana; Stimulation, Chemical; Theophylline | 1974 |
Theophylline inhibition of nucleoside transport and its relation to cyclic AMP in skeletal muscle.
Topics: Adenine; Adenosine; Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Cyclic AMP; Hypoxanthines; In Vitro Techniques; Inosine; Isoproterenol; Muscle Contraction; Muscles; Nucleosides; Phenytoin; Propranolol; Protein Binding; Purines; Rana pipiens; Ribose; Sorbitol; Theophylline; Tritium; Uridine | 1974 |
Hormone-dependent lipolysis in fat-cells from thyroidectomized rats.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cell Membrane; Cyclic AMP; Epinephrine; Fluorides; Glucagon; In Vitro Techniques; Lipid Metabolism; Protein Kinases; Rats; Stimulation, Chemical; Theobromine; Theophylline; Thyroid Gland; Thyroid Hormones; Thyroidectomy | 1974 |
Cyclic AMP-induced tyrosinase synthesis in Neurospora crassa.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Bucladesine; Caffeine; Catechol Oxidase; Cyclic AMP; Cycloheximide; Enzyme Induction; Neurospora; Neurospora crassa; Theophylline | 1974 |
A study of adenosine 3':5'-cyclic monophosphate, sodium butyrate and cortisol as inducers of HeLa alkaline phosphatase.
Topics: Alkaline Phosphatase; Bucladesine; Butyrates; Caffeine; Carboxylic Acids; Cyclic AMP; Enzyme Induction; Epinephrine; Fluorides; HeLa Cells; Humans; Hydrocortisone; Isoproterenol; Kinetics; Prostaglandins; Theophylline; Time Factors; Xanthines | 1974 |
3':5'-cyclic-AMP phosphodiesterase from Trypanosoma gambiense.
Topics: Animals; Caffeine; Cyclic AMP; Dithioerythritol; Enzyme Activation; Hydrogen-Ion Concentration; Imidazoles; Isoelectric Focusing; Kinetics; Magnesium; Manganese; Molecular Weight; Papaverine; Phosphoric Diester Hydrolases; Theophylline; Trypanosoma brucei gambiense | 1974 |
[The treatment of heart and circulatory disorders. 1. Circulatory drugs].
Topics: Acridines; Angiotensin II; Animals; Blood Pressure; Caffeine; Cardiovascular Diseases; Cardiovascular System; Dog Diseases; Dogs; Epinephrine; Norepinephrine; Octopamine; Peristalsis; Theophylline; Vasopressins | 1973 |
Interaction of four methylxanthine compounds and norepinephrine on cardiac phosphorylase activation and cardiac contractility.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Female; Guinea Pigs; Male; Myocardial Contraction; Myocardium; Nicotine; Norepinephrine; Papaverine; Phosphodiesterase Inhibitors; Phosphorylases; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1973 |
Adenosine-3',5'-monophosphate: intracellular mediator for methyl xanthine stimulation of gastric secretion.
Topics: Animals; Bufo marinus; Caffeine; Cyclic AMP; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Rana pipiens; Theophylline; Time Factors; Xanthines | 1969 |
[Pharmaco-isotope nephrogram and 3-stage clearance in functional renal diagnosis].
Topics: Aminophylline; Caffeine; Ethanolamines; Humans; Kidney Function Tests; Radioisotope Renography; Theophylline | 1965 |
The mechanism of the lipolytic action of catecholamines.
Topics: Adenine Nucleotides; Adipose Tissue; Caffeine; Catecholamines; Epinephrine; Ethanolamines; Glycerol; Lipase; Norepinephrine; Phosphotransferases; Theophylline | 1967 |
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.
Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Drug Synergism; Epinephrine; Ethanolamines; Glucagon; In Vitro Techniques; Insulin; Isoproterenol; Luteinizing Hormone; Male; Nicotinic Acids; Norepinephrine; Rats; Theophylline; Thyrotropin | 1968 |
[Current concepts of the mechanism of stimulation and blockade of adrenergic beta-receptors in the heart].
Topics: Adenine Nucleotides; Animals; Caffeine; Catecholamines; Cell Membrane Permeability; Cyclic AMP; Depression, Chemical; Glucosyltransferases; Guinea Pigs; Heart Conduction System; Imidazoles; Isoproterenol; Myocardium; Sensory Receptor Cells; Stimulation, Chemical; Theophylline | 1969 |
[Effect of non-aqueous elution agents on the behavior of extremely weak bases in ion exchange chromatography using an example of pharmaceutical agent mixture].
Topics: 1-Propanol; Antipyrine; Benzamides; Benzoates; Caffeine; Catechols; Central Nervous System Stimulants; Chromatography, Ion Exchange; Chromatography, Thin Layer; Ethanol; Methanol; Salicylamides; Solvents; Spectrophotometry; Tablets; Theophylline; Ultraviolet Rays; Water | 1969 |
On the regulation of glycogen metabolism in Tetrahymena.
Topics: Animals; Caffeine; Culture Media; Cyclic AMP; Depression, Chemical; Glucose; Glucosyltransferases; Glycogen; Isoproterenol; Oxygen; Phosphoric Monoester Hydrolases; Reserpine; Stimulation, Chemical; Tetrahymena; Theophylline; Time Factors; Triiodothyronine; Vibration | 1970 |
[Which drugs can cause glaucoma?].
Topics: Caffeine; Central Nervous System Stimulants; Drug-Related Side Effects and Adverse Reactions; Epinephrine; Ganglionic Blockers; Glaucoma; Humans; Muscle Relaxants, Central; Nitrates; Nitrites; Parasympatholytics; Quaternary Ammonium Compounds; Sulfonamides; Theophylline | 1970 |
Cyclic AMP and adrenergic receptors in melanophore responses to methylxanthines.
Topics: Adenine Nucleotides; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Caffeine; Catecholamines; Chromatophores; Cyclic AMP; Female; In Vitro Techniques; Lizards; Male; Melanocyte-Stimulating Hormones; Sensory Receptor Cells; Stimulation, Chemical; Theobromine; Theophylline; Xanthines | 1970 |
Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.
Topics: Adenine Nucleotides; Caffeine; Central Nervous System Stimulants; Cyclic AMP; Electroshock; Ethers; Fluorine; Hyperbaric Oxygenation; Seizures; Telencephalon; Theophylline; Tritium | 1971 |
Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atropine; Caffeine; Calcium; Calcium Isotopes; Cats; Electric Stimulation; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Norepinephrine; Papillary Muscles; Procaine; Propranolol; Reserpine; Strontium; Strontium Isotopes; Theobromine; Theophylline; Time Factors | 1972 |
Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.
Topics: Animals; Anxiety; Barbiturates; Brain; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Cyclic AMP; Diazepam; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Punishment; Rats; Theobromine; Theophylline; Tranquilizing Agents | 1972 |
Anxiety or caffeinism: a diagnostic dilemma.
Topics: Adult; Anxiety Disorders; Cacao; Caffeine; Carbonated Beverages; Coffee; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Humans; Male; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders; Tea; Theobromine; Theophylline | 1974 |
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography.
Topics: Administration, Oral; Aminophylline; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Humans; Hypoxanthines; Methylation; Pressure; Theophylline; Uric Acid; Xanthines | 1974 |
Gas chromatographic analysis of theophylline in human serum.
Topics: Caffeine; Chromatography, Gas; Ephedrine; Evaluation Studies as Topic; Humans; Hydrocortisone; Mathematics; Methods; Microchemistry; Theophylline; Time Factors | 1974 |
The enhancement of polypeptide synthesis in mammalian systems by methylxanthines.
Topics: Aminophylline; Anemia; Animals; Caffeine; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Hydroxyapatites; Peptide Biosynthesis; Peptide Elongation Factors; Phenylalanine; Phenylhydrazines; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes; RNA, Transfer; Theobromine; Theophylline; Time Factors; Ultracentrifugation | 1974 |
[Combinated oral antiasthmatics--how effective are they? An invitation to discussion].
Topics: Administration, Oral; Antipyrine; Asthma; Caffeine; Drug Combinations; Ephedrine; Humans; Parasympatholytics; Theophylline | 1974 |
High-pressure liquid chromatographic assay of theophylline in biological fluids.
Topics: Absorption; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Drug Stability; Humans; Hydrogen-Ion Concentration; Oxazepam; Pressure; Spectrophotometry, Ultraviolet; Temperature; Theophylline; Time Factors; Xanthines | 1974 |
[Biological effectiveness of methyl xanthines in cocoa products].
Topics: Animals; Bronchi; Cacao; Caffeine; Cardiovascular System; Central Nervous System; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Female; Humans; Kidney; Mice; Muscles; Receptors, Drug; Theobromine; Theophylline; Xanthines | 1974 |
Relationship between theophylline uptake and inotropic effect in the guinea-pig heart.
Topics: Animals; Caffeine; Coronary Vessels; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Myocardium; Perfusion; Stimulation, Chemical; Theophylline | 1974 |
[The effect of methylxanthines on catecholamine and adenylate nucleotide concentration in rat myocardium].
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Caffeine; Inosine; Inosine Nucleotides; Myocardium; Phosphorus; Rats; Stimulation, Chemical; Strophanthins; Theobromine; Theophylline; Tyramine; Xanthines | 1974 |
[Determination of substances of biochemical and bromatological interest by complex formation with heterpoly acids. The thermic properties of the complex salts].
Topics: Caffeine; Chemical Phenomena; Chemistry; Cytosine; Hot Temperature; Molybdenum; Phosphates; Phosphotungstic Acid; Silicon; Theobromine; Theophylline; Thiamine; Tungsten; Xanthines | 1974 |
Experimental study of the effect of lithium, haloperidol, caffeine and theophylline on convulsive seizure reactions.
Topics: Animals; Caffeine; Drug Synergism; Haloperidol; Lithium; Male; Rats; Seizures; Theophylline | 1974 |
Pyrimidine derivatives and related compounds. XXIII. Synthesis and pharmacological properties of 9-deazaxanthine derivatives.
Topics: Animals; Caffeine; Heart; Kidney; Lethal Dose 50; Mice; Motor Activity; Theophylline; Xanthines | 1974 |
[Comparative investigation on the vitro inhibition of adenosine decomposition by dilazep].
Topics: Adenosine; Adult; Azepines; Benzoates; Caffeine; Cell Membrane Permeability; Dipyridamole; Drug Interactions; Erythrocytes; Ethylenediamines; Humans; In Vitro Techniques; Lidoflazine; Theophylline; Vasodilator Agents | 1974 |
Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells.
Topics: Animals; Caffeine; Carbon Radioisotopes; Cell Line; Cricetinae; DNA; DNA Repair; DNA Replication; L Cells; Leukemia, Lymphoid; Lung; Mice; Mutation; Radiation Effects; Temperature; Theophylline; Thymidine; Ultraviolet Rays | 1974 |
[Differences in the action of etephyl and ethymizol on water and sodium transport through isolated biological membranes].
Topics: Animals; Anura; Caffeine; Cell Membrane Permeability; Imidazoles; In Vitro Techniques; Male; Pituitary Hormones, Posterior; Rana temporaria; Skin; Theophylline; Urinary Bladder | 1972 |
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Gestational Age; Hypoproteinemia; Methylation; Pregnancy; Rats; Theobromine; Theophylline; Xanthines | 1973 |
Topical differences of caffeine action on the smooth muscle cells of the guinea pig alimentary canal.
Topics: Adenosine Triphosphate; Animals; Caffeine; Digestive System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium; Rectum; Stomach; Theophylline | 1974 |
Effect of fructose and other sugars on islet function in vitro.
Topics: Animals; Caffeine; Calcium; Drug Synergism; Fructose; Galactose; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Mannose; Pancreas; Rats; Ribose; Sorbitol; Stimulation, Chemical; Theophylline; Xylitol | 1972 |
Metabolism of caffeine- 3 H in the rat.
Topics: Animals; Caffeine; Chromatography, Thin Layer; Male; Mass Spectrometry; Rats; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Tritium; Uric Acid; Xanthines | 1972 |
Inhibition of alkaline phosphatase by theophylline in vitro.
Topics: Alkaline Phosphatase; Animals; Caffeine; Cattle; Humans; In Vitro Techniques; Intestines; Phosphoenolpyruvate; Spectrophotometry; Theobromine; Theophylline | 1972 |
Mass spectrometric identification of methylxanthines and methyluric acids, the possible metabolites of caffeine.
Topics: Caffeine; Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Theobromine; Theophylline; Uric Acid; Xanthines | 1972 |
[Reaction of purine derivatives with iodine used as a detection reagent. IX].
Topics: Caffeine; Indicators and Reagents; Iodine; Mercaptopurine; Methods; Purines; Spectrophotometry, Infrared; Theobromine; Theophylline | 1972 |
Inhibition of streptolysin O-induced haemolysis by theobromine sodium salicylate.
Topics: Animals; Caffeine; Erythrocytes; Hemolysis; In Vitro Techniques; Rabbits; Salicylates; Streptolysins; Theobromine; Theophylline | 1972 |
On the mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators.
Topics: Acetamides; Adenosine; Animals; Blood Flow Velocity; Caffeine; Cell Membrane Permeability; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Interactions; Erythrocytes; Female; Glycolates; Humans; Male; Piperazines; Receptors, Drug; Structure-Activity Relationship; Theophylline; Vasodilator Agents; Xanthines; Xylenes | 1972 |
[Determination of the N-methyl group in organic substances on the micro and decimomilligram scale].
Topics: Acetanilides; Aminopyrine; Antipyrine; Caffeine; Diphenhydramine; Ephedrine; Indicators and Reagents; Methylation; Microchemistry; Theobromine; Theophylline | 1973 |
A comparative description of inotropic agents in vitro.
Topics: Animals; Caffeine; Calcium; Cats; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Glucagon; Guinea Pigs; Heart; Heart Atria; Histamine; In Vitro Techniques; Manganese; Muscle Contraction; Muscle, Smooth; Norepinephrine; Ouabain; Papillary Muscles; Propranolol; Rabbits; Reserpine; Serotonin; Temperature; Theophylline; Time Factors | 1973 |
Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. 3. The determination of alkaloids and alkaloidal salts.
Topics: Alkaloids; Atropine; Caffeine; Codeine; Ephedrine; Indicators and Reagents; Methods; Microchemistry; Nicotine; Papaverine; Polymers; Quinine; Salts; Strychnine; Temperature; Theophylline | 1973 |
[Drug interference and incompatibilities of drugs attacking the central nervous system. 2. Stimulants].
Topics: Caffeine; Central Nervous System; Drug Antagonism; Drug Interactions; Drug Synergism; Humans; Methamphetamine; Methylphenidate; Stimulation, Chemical; Sympathomimetics; Theophylline | 1973 |
[Gastrin release by methylxanthine].
Topics: Adult; Caffeine; Gastric Juice; Gastrins; Humans; Injections, Intravenous; Middle Aged; Stimulation, Chemical; Theophylline | 1973 |
Urinary excretion of 3 -methylxanthine and related compounds in children.
Topics: Adolescent; Adult; Cacao; Caffeine; Child; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Paper; Coffee; Diet; Humans; Infant; Intellectual Disability; Mass Spectrometry; Methylation; Neuromuscular Diseases; Spectrophotometry, Ultraviolet; Stereoisomerism; Tea; Theobromine; Theophylline; Xanthines | 1973 |
Application of quantitative thin-layer chromatography in drug assay and stability testing. Determination of codeine phosphate, noscapine, diphenhydramine hydrochloride, phenylephrine hydrochloride, caffeine, etofyllin, phenobarbital and thiamine hydrochlo
Topics: Autoanalysis; Caffeine; Chromatography, Thin Layer; Codeine; Diphenhydramine; Drug Combinations; Drug Stability; Methods; Noscapine; Pharmaceutical Preparations; Phenobarbital; Phenylephrine; Spectrum Analysis; Theophylline; Thiamine | 1973 |
Stimulation of human spermatozoal motility by caffeine.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminophylline; Caffeine; Drug Synergism; Fructose; Glucose; Humans; Lactates; Male; Pyruvates; Spermatozoa; Theophylline | 1973 |
The effects of caffeine and theophylline on nociceptive stimulation in the rat.
Topics: Animals; Caffeine; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intraperitoneal; Male; Motor Activity; Neural Conduction; Pain; Placebos; Rats; Stimulation, Chemical; Theophylline; Time Factors; Vocalization, Animal | 1973 |
Chlorination studies. IV. The reaction of aqueous hypochlorous acid with pyrimidine and purine bases.
Topics: Adenine; Bromouracil; Caffeine; Chemical Phenomena; Chemistry; Guanine; Mass Spectrometry; Purines; Pyrimidines; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Theophylline; Thymine; Uracil; Xanthines | 1973 |
The action of gut glucagon-like immunoreactivity and other intestinal hormones on lipolysis in chicken adipocytes.
Topics: Adipose Tissue; Animals; Antigen-Antibody Reactions; Caffeine; Chickens; Cholecystokinin; Drug Synergism; Ducks; Duodenum; Gastrins; Gastrointestinal Hormones; Glucagon; Jejunum; Lipid Metabolism; Pancreas; Rats; Secretin; Swine; Theophylline; Tissue Extracts | 1973 |
Factors influencing deceleration of heart and respiratory rates after exercise in the horse.
Topics: Amphetamine; Animals; Caffeine; Diethylamines; Electrocardiography; Ephedrine; Female; Heart Rate; Horses; Male; Physical Exertion; Respiration; Sweating; Telemetry; Temperature; Theophylline | 1973 |
The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium.
Topics: Action Potentials; Animals; Biological Transport; Caffeine; Calcium; Cell Membrane; Cell Membrane Permeability; Coronary Disease; Cyanides; Depression, Chemical; Dinitrophenols; Electrochemistry; Guinea Pigs; Heart Rate; Hypoxia; Isoproterenol; Membrane Potentials; Myocardial Infarction; Myocardium; Potassium; Sodium; Theophylline; Xanthines | 1974 |
The effect of theophylline on tryptophan pyrrolase in the hypophysectomized rat and some observations on the validity of tryptophan pyrrolase assays.
Topics: Animals; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Chromatography, Paper; Cycloheximide; Dactinomycin; Enzyme Activation; Hydrocortisone; Hypophysectomy; Kinetics; Liver; Male; Models, Chemical; Perfusion; Pituitary Gland; Rats; Theophylline; Tryptophan; Tryptophan Oxygenase | 1974 |
Determination of theophylline and probenecid in biological material.
Topics: Animals; Brain Chemistry; Caffeine; Chloroform; Chromatography; Chromatography, Gas; Hydrogen-Ion Concentration; Methods; Probenecid; Solvents; Theobromine; Theophylline; Water | 1974 |
The use of modified cellulose papers in routine toxicological analysis. 3. Xanthine CNS stimulants and antipyretics.
Topics: Analgesics; Caffeine; Cellulose; Central Nervous System; Chromatography, Paper; Paper; Theobromine; Theophylline; Xanthines | 1974 |
The influence of analogs of xanthine on the mutagenic effect of ultraviolet light.
Topics: Caffeine; Drug Synergism; Escherichia coli; Mutation; Purines; Theophylline; Ultraviolet Rays; Uric Acid; Xanthines | 1968 |
Identification of drugs in the preimplantation blastocyst and in the plasma, uterine secretion and urine of the pregnant rabbit.
Topics: Animals; Barbiturates; Caffeine; Carbon Isotopes; DDT; Embryo Implantation; Endometrium; Female; Isoniazid; Molecular Weight; Nicotine; Ovum; Pregnancy; Rabbits; Radioisotope Dilution Technique; Theophylline; Thiopental; Tritium; Uterus; Xanthines | 1971 |
Effect of caffeine on adenylosuccinate lyase synthesis in Bacillus subtilis.
Topics: Bacillus subtilis; Caffeine; Culture Media; Dactinomycin; Lyases; Nucleosides; Nucleotides; Oxidoreductases; Puromycin; Succinates; Theobromine; Theophylline; Time Factors; Transferases; Xanthines | 1969 |
Inhibition of L-alanine-induced germination of Bacillus cereus spores by theophylline.
Topics: Adenine; Alanine; Bacillus cereus; Caffeine; Drug Synergism; Guanine; Hydrogen-Ion Concentration; Inosine; Spores, Bacterial; Temperature; Theophylline | 1971 |
Effect of theobromine, theophylline and caffeine on the mitosis of human lymphocytes.
Topics: Caffeine; Cells, Cultured; Colchicine; Female; Humans; Lectins; Lymphocytes; Male; Methods; Mitosis; Sex Factors; Theobromine; Theophylline | 1972 |
[Pharmacological effects on the contraction frequency of isolated rat portal vein].
Topics: Aconitum; Animals; Atropine; Caffeine; Carbachol; Epinephrine; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Nitrites; Norepinephrine; Papaverine; Peptides; Phentolamine; Portal Vein; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Reserpine; Strophanthins; Theophylline; Tyramine | 1972 |
Effects of caffeine and theophylline on activity of rats in relation to brain xanthine concentrations.
Topics: Animals; Blood Proteins; Body Temperature; Brain; Caffeine; Male; Motor Activity; Muscles; Protein Binding; Rats; Stimulation, Chemical; Theophylline; Xanthines | 1972 |
Complexation of acetaminophen with methyl xanthines.
Topics: Acetaminophen; Caffeine; Calorimetry; Chemistry, Pharmaceutical; Kinetics; Magnetic Resonance Spectroscopy; Solubility; Spectrophotometry; Spectrum Analysis; Theobromine; Theophylline | 1972 |
[Solubilization of khellin due to caffeine and dihydroxypropyltheophylline].
Topics: Caffeine; Chelating Agents; Chemistry, Pharmaceutical; Drug Stability; Khellin; Solubility; Spectrophotometry; Theophylline; Thermodynamics; Xanthines | 1972 |
[Effect of caffeine and dihydroxyprophyltheophylline on the replacement rate of khellin].
Topics: Caffeine; Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Khellin; Kinetics; Mathematics; Temperature; Theophylline; Xanthines | 1972 |
[Studies on analysis of mixed anti-cold pharmaceutical preparations. IX. Application of countercurrent distribution method].
Topics: Caffeine; Chlorpheniramine; Codeine; Countercurrent Distribution; Ephedrine; Methods; Solubility; Theophylline | 1971 |
Caffeine metabolism by Penicillium roqueforti.
Topics: Caffeine; Carbon Isotopes; Chromatography, Thin Layer; Dealkylation; Penicillium; Theobromine; Theophylline | 1971 |
Determination of theophylline and caffeine from biological materials.
Topics: Animals; Brain Chemistry; Caffeine; Half-Life; Male; Muscles; Protein Binding; Rats; Rats, Inbred Strains; Theophylline | 1971 |
An infrared study of the interaction of caffeine and theophylline with 9-ethyladenine in chloroform solution.
Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chloroform; DNA Repair; Drug Interactions; Infrared Rays; Solutions; Spectrum Analysis; Theophylline | 1971 |
Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips.
Topics: Animals; Aorta; Caffeine; Catecholamines; Cycloparaffins; Drug Synergism; Epinephrine; In Vitro Techniques; Ketones; Methoxamine; Methylation; Muscle Contraction; Muscle, Smooth; Norepinephrine; Normetanephrine; Phenylephrine; Propiophenones; Pyrogallol; Rabbits; Reserpine; Synephrine; Theophylline; Xanthines | 1971 |
[Electroencephalographic study of the local injection of central nervous stimulants into the brain--xanthinol nicotinate, CDP-choline, caffein and sodium benzoate].
Topics: Animals; Benzoates; Brain; Caffeine; Cats; Cytosine Nucleotides; Electroencephalography; Hypothalamus; Injections; Mesencephalon; Nicotinic Acids; Pons; Theophylline | 1971 |
The influence of reserpine, propranolol, and adrenal medullectomy on the hyperglycemic actions of theophylline and caffeine.
Topics: Adrenal Medulla; Aminophylline; Animals; Blood Glucose; Body Temperature; Caffeine; Male; Propranolol; Rats; Reserpine; Stimulation, Chemical; Theophylline; Time Factors | 1969 |
[Solubilization of purines].
Topics: Caffeine; Polyvinyls; Purines; Solubility; Theobromine; Theophylline | 1969 |
Teratogenic actions of some methylated xanthines in mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Injections, Intraperitoneal; Male; Mice; Pregnancy; Teratoma; Theobromine; Theophylline | 1969 |
[Simultaneous spectrophotometric determination of the components of a binary mixture with graphic resolution. II].
Topics: Amino Alcohols; Caffeine; Spectrophotometry; Theophylline | 1969 |
[Simultaneous spectrophotometric determination of the components of a binary mixture with graphic resolution. I].
Topics: Amino Alcohols; Caffeine; Spectrophotometry; Theophylline | 1969 |
Dynamic dialysis as a method for studying protein binding. II. Evaluation of the method with a number of binding systems.
Topics: Caffeine; Coloring Agents; Dialysis; Hydrogen-Ion Concentration; Kinetics; Methods; Protein Binding; Serum Albumin, Bovine; Spectrophotometry; Theophylline; Warfarin | 1970 |
Molecular interactions of pyrimidines, purines, and some other heteroaromatic compounds in aqueous media.
Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chloroquine; Drug Stability; Guanidines; Hypoxanthines; Nucleosides; Purines; Pyrimidines; Quinoxalines; Solubility; Theophylline; Tritium; Water | 1970 |
Complexes of ergot alkaloids and derivatives. 3. Interaction of dihydroergocristine with xanthine analogs in aqueous media.
Topics: Absorption; Animals; Buffers; Caffeine; Cats; Chemical Phenomena; Chemistry; Drug Synergism; Ergot Alkaloids; Humans; Hydrogen-Ion Concentration; Solubility; Spectrophotometry; Sympathetic Nervous System; Theophylline; Time Factors; Tritium; Water; Xanthines | 1970 |
Detection of theophylline and theobromine by reactions with mercury (II) cyanide.
Topics: Caffeine; Chemical Phenomena; Chemistry; Cyanides; Mercury; Theobromine; Theophylline; Xanthines | 1970 |
[Factors influencing behaviour in thin-layer chromatography. 2. Thin-layer chromatography of caffeine, theophylline and theobromine on pH gradient layers].
Topics: Caffeine; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Theobromine; Theophylline | 1970 |
[Study of the mechanism of the positive inotropic effect exercised by methylxanthines on the isolated perfused rat heart].
Topics: Animals; Caffeine; Cardiac Output; Drug Antagonism; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Methods; Norepinephrine; Propranolol; Rats; Reserpine; Theophylline; Xanthines | 1970 |
[Advantage of a new therapeutic agent for respiratory dyspneic diseases].
Topics: Asthma; Bronchial Diseases; Bronchodilator Agents; Caffeine; Dyspnea; Male; Parasympatholytics; Theophylline | 1970 |
[Factors influencing behavior in thin-layer chromatography. I. The influence of the pH value in thin-layer chromatography of caffeine theophylline and theobromine on uniform layers].
Topics: Acids; Ammonia; Caffeine; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Theobromine; Theophylline | 1970 |
[Hepatotoxicity of caffeine and theophylline].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Carbon Tetrachloride Poisoning; Cholesterol; Depression, Chemical; Fats; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Heart Diseases; Lipid Metabolism; Liver; Male; Necrosis; Rats; Stimulation, Chemical; Theophylline; Time Factors | 1970 |
Effect of complex formation on the intestinal absorption of tryptophan.
Topics: Animals; Caffeine; Flavin Mononucleotide; Intestinal Absorption; Kinetics; Male; Methionine; Perfusion; Rats; Spectrophotometry; Theophylline; Tryptophan | 1970 |
Binding specificity between small organic solutes in aqueous solution: classification of some solutes into two groups according to binding tendencies.
Topics: Caffeine; Cinnamates; Drug Stability; Mathematics; Phenacetin; Solubility; Theophylline | 1970 |
[Interaction between xanthines and noradrenaline- 3 H in the isolated rat heart].
Topics: Animals; Caffeine; Cardiac Output; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Myocardium; Norepinephrine; Perfusion; Rats; Theobromine; Theophylline; Tritium | 1970 |
[Effect of caffeine on the autoregulation of perfusion flow in the isolated, artificially perfused rat kidney].
Topics: Animals; Caffeine; Depression, Chemical; In Vitro Techniques; Kidney; Perfusion; Rats; Reserpine; Rheology; Theophylline; Tyramine | 1971 |
[On the occurrence of theophylline in coffee].
Topics: Caffeine; Chromatography, Thin Layer; Coffee; Theobromine; Theophylline | 1967 |
[Contribution to the treatment of depressions].
Topics: Aged; Antidepressive Agents; Caffeine; Depression; Depressive Disorder, Major; Female; Humans; Injections, Intravenous; Male; Middle Aged; Suicide Prevention; Testosterone; Theophylline; Vasodilator Agents; World Health Organization | 1967 |
[Electronic properties of N-heteroaromatics. XI. Interaction of p-benzoquinone with caffeine and theophylline].
Topics: Caffeine; Electrochemistry; Quinones; Solubility; Spectrum Analysis; Theophylline | 1967 |
[Studies on caffeine from synthesis and biosynthesis].
Topics: Caffeine; Chromatography; Chromatography, Thin Layer; Methods; Pharmacopoeias as Topic; Plants, Medicinal; Theobromine; Theophylline | 1967 |
Permeation of purine derivatives into the cerebrospinal fluid of dogs.
Topics: Amphetamine; Animals; Benzoates; Blood-Brain Barrier; Caffeine; Dogs; Ethylenediamines; Theobromine; Theophylline | 1968 |
The effect of caffeine on drug metabolism.
Topics: Acetanilides; Aminopyrine; Animals; Caffeine; Enzyme Induction; Ethionine; Liver; Microsomes; Nitrobenzenes; Puromycin; Rats; Theobromine; Theophylline | 1968 |
Interactions of xanthine derivatives with bovine serum albumin. 3. Inhibition of binding.
Topics: Acetates; Aspirin; Benzoates; Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Chlorides; Hydrogen-Ion Concentration; Nitrates; Potassium; Protein Binding; Salicylates; Serum Albumin, Bovine; Sodium; Sulfates; Theophylline; Xanthines | 1968 |
Structural studies on complexes. I. Postulation of polarization bonding in xanthine complexes.
Topics: Caffeine; Chemical Phenomena; Chemistry; Electrochemistry; Models, Chemical; Theophylline; Uric Acid; Xanthines | 1968 |
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental | 1968 |
[Determination of theophylline, caffeine and ephedrine hydrochloride in the preparation Belladrinal tablet].
Topics: Caffeine; Chlorides; Chromatography, Paper; Colorimetry; Ephedrine; Methods; Potentiometry; Tablets; Theophylline | 1968 |
Interaction of copper ion with guanosine and related compounds.
Topics: Caffeine; Chemical Phenomena; Chemistry; Copper; Cytosine Nucleotides; Electric Conductivity; Guanine Nucleotides; Models, Structural; Nucleosides; Nucleotides; Potentiometry; Ribose; Spectrophotometry; Theophylline; Uracil Nucleotides; Uridine | 1968 |
Determination of molecular binding in aqueous solution from optical activity measurements. Interaction of tryptophan with alkylxanthines.
Topics: Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Mathematics; Methods; Optical Rotatory Dispersion; Spectrum Analysis; Theophylline; Tryptophan; Xanthines | 1968 |
[Diuretic effect of purine derivatives based on the perfusion of the isolated kidney of dogs].
Topics: Animals; Caffeine; Diuretics; Dogs; Glomerular Filtration Rate; Kidney; Oxygen Consumption; Perfusion; Potassium; Sodium; Theobromine; Theophylline; Time Factors; Vascular Resistance | 1968 |
Effect of adenine nucleotides on thyroid hormone release in vivo and in vitro.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Caffeine; Drug Synergism; Fluorides; In Vitro Techniques; Iodine Isotopes; Mice; Nucleosides; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine | 1969 |
Interactions between pharmaceutical compounds by thermal methods.
Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K | 1969 |
[On the mechanism of the calorigenic effect of theophylline and caffeine].
Topics: Adrenal Medulla; Adrenalectomy; Anesthesia; Animals; Caffeine; Calorimetry; Epinephrine; Oxygen Consumption; Propranolol; Rats; Reserpine; Theophylline; Wakefulness | 1969 |
Determination of caffeine in serum and urine.
Topics: Benzene; Caffeine; Indicators and Reagents; Methods; Spectrum Analysis; Theobromine; Theophylline | 1969 |
Interactions of xanthine derivatives with bovine serum albumin. II. Spectrophotometric studies.
Topics: Caffeine; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Serum Albumin, Bovine; Spectrophotometry; Temperature; Theophylline; Xanthines | 1965 |
Solubility profiles for the xanthines in dioxane--water mixtures.
Topics: Caffeine; Dioxins; Solubility; Spectrophotometry; Theobromine; Theophylline | 1965 |
[A new method for thin-layer chromatographic separation of caffeine, theobromin and theophylline].
Topics: Caffeine; Chromatography, Thin Layer; In Vitro Techniques; Theobromine; Theophylline | 1965 |
Quantum chemical considerations on the stability of aqueous solution of an electron acceptor such as menadione.
Topics: Antipyrine; Caffeine; Chemical Phenomena; Chemistry, Physical; Theophylline; Vitamin K | 1965 |
[Study of solvent effect on nuclear magnetic resonance. I. Caffeine and its derivatives].
Topics: Caffeine; Hydrocarbons, Halogenated; Magnetic Resonance Spectroscopy; Solvents; Theobromine; Theophylline | 1965 |
Analysis of selected pharmaceuticals by quantitative thin-layer chromatography.
Topics: Amphetamine; Aspirin; Barbiturates; Caffeine; Chromatography, Thin Layer; Ephedrine; Methamphetamine; Phenacetin; Salicylates; Theophylline | 1966 |
[Thin-layer chromatographic separation of some purine derivatives, including uric acid].
Topics: Adenine; Caffeine; Chromatography, Thin Layer; Guanine; Hypoxanthines; Purines; Theobromine; Theophylline; Uric Acid; Xanthines | 1966 |
[Caffeine and theophyllin mutagenesis in cell and leukocyte cultures of man].
Topics: Caffeine; Chromosomes; Culture Techniques; Leukocytes; Mutagens; Theophylline | 1966 |
[Detection of caffeine, theophylline, theobromine and some of their derivatives by thin layer chromatography].
Topics: Blood Chemical Analysis; Caffeine; Chromatography, Thin Layer; Humans; Indicators and Reagents; Male; Solvents; Theobromine; Theophylline; Urine | 1966 |
[Gas chromatographic separation of various xanthine derivatives].
Topics: Caffeine; Chromatography, Gas; Theobromine; Theophylline; Xanthines | 1966 |
[Determination of Theobromine and its metabolites in urine].
Topics: Caffeine; Chromatography, Paper; Food Contamination; Humans; Spectrophotometry; Theobromine; Theophylline; Xanthines | 1966 |
[The treatment of bronchial asthma and the combination treatment of acute and chronic bronchial, bronchopulmonary and pulmonary infections with Asthma 23D. An experience report of medical practice during the time period of 5 years].
Topics: Acute Disease; Adult; Aminopyrine; Anti-Bacterial Agents; Antitubercular Agents; Asthma; Atropa belladonna; Bronchitis; Caffeine; Child; Child, Preschool; Chronic Disease; Ephedrine; Humans; Infant; Naphthaleneacetic Acids; Papaverine; Phytotherapy; Plants, Medicinal; Plants, Toxic; Pulmonary Emphysema; Theophylline; Tuberculosis, Pulmonary | 1966 |
Potential anticancer agents V. Synthesis of folic acid and pteroic acid analogs derived of caffeine and theophylline.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Caffeine; Folic Acid; Leukemia, Experimental; Mice; Theophylline | 1966 |
The action of imidazole on the effects of methyl-xanthines and catecholamines on cardiac contraction and phosphorylase activity.
Topics: Adenine Nucleotides; Aminophylline; Animals; Caffeine; Drug Antagonism; Glucosyltransferases; Guinea Pigs; Heart; Imidazoles; Isoproterenol; Myocardium; Norepinephrine; Perfusion; Rabbits; Theophylline | 1967 |
Modification of reaction rates by complex formation. II. Inhibition of the rate of alkaline hydrolysis of methyl trans-cinnamate by some heterocyclic compounds.
Topics: Acetates; Benzimidazoles; Caffeine; Chemical Phenomena; Chemistry; Cinnamates; Guanine; Imidazoles; Purines; Theophylline; Uracil | 1967 |
Effect of functional group substituents on the paper chromatography of purines and pyrimidines.
Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Paper; Cytosine; Guanine; Hydrogen-Ion Concentration; Nitriles; Purines; Pyrimidines; Theobromine; Theophylline; Thymine; Uracil; Water; Xanthines | 1967 |
Electrical conductivity of a docusate sodium coacervate system.
Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Cytoplasm; Dioctyl Sulfosuccinic Acid; Electric Conductivity; Glucose; Glucosephosphates; Humans; Models, Biological; Succinates; Sucrose; Theobromine; Theophylline | 1984 |
Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Caffeine; Carbamazepine; Cerebellum; Cerebral Cortex; Cyclic AMP; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1984 |
Adrenergic-cholinergic interactions on membrane potential of K+ -depolarized ventricular muscle.
Topics: Acetylcholine; Action Potentials; Animals; Barium; Caffeine; Electric Conductivity; Guinea Pigs; Histamine; Ion Channels; Isoproterenol; Manganese; Myocardial Contraction; Potassium; Receptors, Adrenergic, beta; Receptors, Muscarinic; Theophylline | 1984 |
Adenosine analogs: potentiation of bradykinin-induced plasma exudation in rat skin and prevention by caffeine and theophylline.
Topics: Adenosine; Animals; Bradykinin; Caffeine; Capillary Permeability; Cyproheptadine; Drug Synergism; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Skin; Theophylline | 1984 |
Central nervous system pharmacology of the dietary methylxanthines.
Topics: Acetylcholine; Adolescent; Adult; Aged; Body Weight; Caffeine; Central Nervous System; Diet; Dopamine; Dose-Response Relationship, Drug; Feeding Behavior; Female; Humans; Lethal Dose 50; Male; Middle Aged; Motor Activity; Norepinephrine; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; Serotonin; Sleep; Substance-Related Disorders; Theobromine; Theophylline | 1984 |
The effects of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperatures.
Topics: Animals; Body Temperature Regulation; Caffeine; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Phentolamine; Propranolol; Rats; Temperature; Theophylline | 1980 |
The effects of melanophore-stimulating hormone and cyclic nucleotides on teleost fish chromatophores.
Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Bucladesine; Caffeine; Chromatophores; Cyclic AMP; Dibutyryl Cyclic GMP; Epinephrine; Fishes; Melanocyte-Stimulating Hormones; Melanophores; Nucleotides, Cyclic; Pigmentation; Theophylline | 1980 |
Effects of methylxanthines on lipid synthesis in developing neural systems.
Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol; Fatty Acid Synthases; Fatty Acids; Female; Glioma; Humans; Lipids; Pregnancy; Theophylline | 1981 |
Adenosine mediates sedative action of various centrally active drugs.
Topics: Adenosine; Animals; Antipsychotic Agents; Arousal; Brain; Caffeine; Diazepam; Hypnotics and Sedatives; Phenothiazines; Rats; Receptors, Cell Surface; Receptors, Purinergic; Synapses; Synaptic Transmission; Synaptosomes; Theophylline | 1982 |
Effects of c-AMP, caffeine, theophylline, and vinblastine on spontaneous transmitter release at locust nerve-muscle junctions.
Topics: Animals; Caffeine; Cyclic AMP; Grasshoppers; In Vitro Techniques; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Synaptic Transmission; Theophylline; Vinblastine | 1983 |
External malformations in chick embryos following concomitant administration of methylxanthines and beta-adrenomimetic agents: 1. Gross pathologic features.
Topics: Abnormalities, Drug-Induced; Adrenergic beta-Agonists; Animals; Caffeine; Chick Embryo; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fetal Viability; Isoproterenol; Mitosis; Norepinephrine; Phenylephrine; Theophylline | 1983 |
Behavioural problems in children taking theophylline.
Topics: Adult; Asthma; Caffeine; Child; Child Behavior Disorders; Depressive Disorder; Female; Humans; Theophylline | 1984 |
Interactions between catecholamines, methyl xanthines and adenosine in regulation of cyclic AMP accumulation in hamster adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Caffeine; Catecholamines; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Mesocricetus; Norepinephrine; Phentolamine; Theophylline | 1980 |
Methylxanthines modulate adenosine release from slices of cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine Triphosphatases; Aminophylline; Animals; Caffeine; Cerebral Cortex; Cyclic AMP; gamma-Aminobutyric Acid; Male; Mice; Ouabain; Theophylline; Xanthines | 1981 |
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines | 1981 |
Methylxanthine effects on cyclic adenosine 3':5' monophosphate phosphodiesterase activity in preparations of neonatal rat cerebellum: modification by trifluoperazine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Animals, Newborn; Caffeine; Cerebellum; Drug Interactions; In Vitro Techniques; Kinetics; Rats; Theophylline; Trifluoperazine | 1981 |
Adenosine 3',5'-phosphate phosphodiesterase and pheromone response in the yeast Saccharomyces cerevisiae.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Caffeine; Cyclic AMP; Interphase; Mating Factor; Peptides; Saccharomyces cerevisiae; Theophylline; Xanthines | 1981 |
cAMP and calcium in generation of slow waves in cat colon.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Caffeine; Calcium; Cats; Colon; Cyclic AMP; Dibutyryl Cyclic GMP; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Theophylline; Time Factors | 1982 |
The action of phosphodiesterase inhibitors on the hypersensitivity of frog photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; In Vitro Techniques; Light; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Rana catesbeiana; Theophylline | 1982 |
Blockade by haloperidol of the increase in tryptophan hydroxylase activity induced by incubation of slices of brain stem with dibutyryl cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Stem; Bucladesine; Caffeine; Calcium; Haloperidol; Male; Rats; Theophylline; Tryptophan Hydroxylase | 1982 |
Theophylline, dyphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay.
Topics: Acecainide; Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Pharmaceutical Preparations; Procainamide; Salicylates; Salicylic Acid; Theophylline | 1982 |
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline | 1982 |
Development and initiation of sperm motility in the hamster epididymis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cricetinae; Cyclic AMP; Epididymis; Kinetics; Male; Semen; Sperm Motility; Spermatozoa; Theophylline | 1980 |
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors | 1984 |
Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Biological Transport, Active; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Male; Mollusca; Potassium Cyanide; Spermatozoa; Theobromine; Theophylline; Xanthines | 1984 |
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines | 1984 |
Behavioral interaction of adenosine and methylxanthines on central purinergic systems.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline | 1984 |
Caffeine and related methylxanthines: possible naturally occurring pesticides.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Chlorphenamidine; Cyclic AMP; Feeding Behavior; Insecta; Insecticides; Larva; Lepidoptera; Moths; Papaverine; Pesticide Synergists; Theophylline; Xanthines | 1984 |
The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Caffeine; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline; Xanthines | 1984 |
Mode of inhibition of DNA replication in neocarzinostatin-treated HeLa cells.
Topics: Antibiotics, Antineoplastic; Caffeine; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Kinetics; Molecular Weight; Theophylline; Zinostatin | 1983 |
cAMP phosphodiesterase and activator protein of mammalian cAMP phosphodiesterase from Trypanosoma cruzi.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Calcium; Calcium-Binding Proteins; Calmodulin; Cyclic AMP; Enzyme Activation; Hydrogen-Ion Concentration; Manganese; Theophylline; Trypanosoma cruzi | 1980 |
Effect of cyclic AMP phosphodiesterase inhibitors on cardiac sarcolemmal 5'-nucleotidase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 5'-Nucleotidase; Animals; Caffeine; Dipyridamole; In Vitro Techniques; Male; Myocardium; Nucleotidases; Papaverine; Rats; Sarcolemma; Theophylline | 1981 |
Inhibition of 2',3'-cyclic nucleotide 3'-phosphodiesterase activity from bovine, human and guinea pig brain.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain; Caffeine; Cattle; Guinea Pigs; Humans; Kinetics; Oligodendroglia; Organomercury Compounds; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Theophylline | 1981 |
Effect of cAMP, Mn2+, and phosphodiesterase inhibitors on human sperm motility.
Topics: Caffeine; Cyclic AMP; Humans; Male; Manganese; Phosphodiesterase Inhibitors; Sperm Motility; Theophylline; Time Factors | 1981 |
Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP.
Topics: Animals; Bucladesine; Caffeine; Cell Division; Cells, Cultured; Cricetinae; Cricetulus; Female; Ovary; Theobromine; Theophylline; X-Rays | 1982 |
Possible role of the transverse tubules in accumulating calcium released from the terminal cisternae by stimulation and drugs.
Topics: Animals; Anura; Caffeine; Calcium; Electric Stimulation; In Vitro Techniques; Ion Channels; Muscle Contraction; Muscles; Strontium; Theophylline | 1982 |
Intracellular Ca2+ transients in the cat papillary muscle.
Topics: Action Potentials; Aequorin; Animals; Caffeine; Calcium; Cats; Cyclic AMP; Dogs; Heart; In Vitro Techniques; Ion Channels; Myocardial Contraction; Papillary Muscles; Sarcoplasmic Reticulum; Theophylline; Troponin; Troponin C | 1982 |
Fetal lung in organ culture. IV. Supra-additive hormone interactions.
Topics: Animals; Bucladesine; Caffeine; Choline; Dexamethasone; Drug Synergism; Hormones; Lung; Organ Culture Techniques; Phosphatidylcholines; Rats; Theophylline; Triiodothyronine | 1982 |
Endogenous peptides that inhibit brain cyclic AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Brain Chemistry; Caffeine; Cattle; Chromatography, Gel; Male; Molecular Weight; Peptides; Rats; Theophylline | 1982 |
Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain.
Topics: Adenosine; Binding, Competitive; Brain; Caffeine; Diazepam; Humans; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Purinergic; Theophylline; Xanthines | 1982 |
Inhibition of a high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Dogs; Etazolate; Female; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Theophylline; Trachea; Xanthines | 1982 |
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines.
Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Animals; Brain; Caffeine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theobromine; Theophylline; Xanthines | 1983 |
Evidence for the presence of P1- and P2-purinoceptors in rat caecum.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Caffeine; Cecum; Cyclic AMP; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Quinidine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1983 |
Influence of carbohydrates on growth and sporulation of Clostridium perfringens in a defined medium with or without guanosine.
Topics: Caffeine; Carbohydrates; Clostridium perfringens; Culture Media; Dextrins; Glucose; Guanosine; Melibiose; Raffinose; Spores, Bacterial; Sucrose; Theophylline | 1983 |
Caffeine inhibition of aflatoxin production: mode of action.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Aflatoxins; Aspergillus; Caffeine; Cell Nucleus; Cytoplasm; Guanine; Structure-Activity Relationship; Theophylline; Trace Elements | 1983 |
Interaction between methylxanthines and the benzodiazepine receptor.
Topics: Animals; Brain; Caffeine; Flunitrazepam; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Theophylline | 1983 |
In vitro and in vivo displacement of [3H]-diazepam binding by purine derivatives in developing rat brain.
Topics: Animals; Binding, Competitive; Brain; Caffeine; Diazepam; Female; In Vitro Techniques; Kinetics; Male; Membranes; Pregnancy; Purines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Theophylline | 1984 |
Opposing actions of methylxanthines and dibutyryl cyclic AMP on 1,25 dihydroxyvitamin D3 production and calcium fluxes in isolated chick renal tubules.
Topics: Animals; Bucladesine; Caffeine; Calcitriol; Calcium; Chickens; Cyclic AMP; In Vitro Techniques; Kidney Tubules; Male; Mitochondria; Theophylline | 1984 |
Concurrent measurement of theophylline and caffeine in neonates by an interference-free liquid-chromatographic method.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Theophylline | 1983 |
Effect of colchicine & methylated purines on UV-induced mitotic gene conversion in Saccharomyces cerevisiae.
Topics: Caffeine; Colchicine; Gene Conversion; Genes, Fungal; Mitosis; Saccharomyces cerevisiae; Theobromine; Theophylline; Ultraviolet Rays | 1983 |
Evaluation of caffeine plasma levels by an automated enzyme immunoassay (EMIT) in comparison with a high-performance liquid chromatographic method.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Liver Diseases; Reagent Kits, Diagnostic; Theophylline | 1984 |
Stereospecific stimulation of coronary vascular PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
Topics: Animals; Caffeine; Cattle; Coronary Vessels; Epoprostenol; In Vitro Techniques; Muscle Relaxation; Nitrates; Sugar Alcohols; Theophylline | 1984 |
Induction at high frequency of a unique phenotypic class of Bacillus subtilis mutants by methylxanthines.
Topics: Acriflavine; Aminoacridines; Bacillus subtilis; Caffeine; Mutagenicity Tests; Mutagens; Mutation; Phenotype; Structure-Activity Relationship; Theophylline | 1983 |
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Mitomycin; Mitomycins; Pregnancy; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1983 |
[Effect of CNS stimulators on conditioned reflex activity in rats].
Topics: Amphetamine; Amphetamines; Animals; Caffeine; Central Nervous System Agents; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Quinolines; Quinolones; Rats; Reinforcement, Psychology; Stimulation, Chemical; Theophylline | 1984 |
The effects of caffeine and theophylline on diaphragm contractility.
Topics: Adult; Caffeine; Catheterization; Diaphragm; Electromyography; Esophagus; Humans; Male; Muscle Contraction; Pressure; Stomach; Theophylline | 1984 |
Caffeine measured in serum from infants with the theophylline channel of the Abbott TDx.
Topics: Autoanalysis; Caffeine; Humans; Infant, Newborn; Theophylline | 1984 |
Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Conditioning, Psychological; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline; Xanthines | 1984 |
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines | 1984 |
Differences in steady-state plasma levels between aminophylline and theophylline sustained-release micropellets after repeated circadian dosing.
Topics: Absorption; Administration, Oral; Adult; Aminophylline; Biological Availability; Caffeine; Chromatography, High Pressure Liquid; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Humans; Kinetics; Male; Random Allocation; Theophylline | 1984 |
Ontogeny of human caffeine and theophylline metabolism.
Topics: Adult; Aged; Apnea; Caffeine; Child; Child, Preschool; Half-Life; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Middle Aged; Theophylline | 1984 |
[Effect of theophylline and theobromine on cell respiration and calcium transport in isolated rat liver mitochondria].
Topics: Animals; Biological Transport, Active; Caffeine; Calcium; Female; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1984 |
Caffeine and its metabolites in caffeine overdose cause falsely elevated serum theophylline measurements.
Topics: Caffeine; Chromatography, High Pressure Liquid; False Positive Reactions; Female; Humans; Infant; Theophylline | 1984 |
Caffeine, theophylline and theobromine in pregnancy.
Topics: Caffeine; Female; Humans; Pregnancy; Theobromine; Theophylline | 1984 |
Unsuspected caffeine toxicity complicating theophylline therapy.
Topics: Bronchitis; Caffeine; Half-Life; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Theophylline | 1984 |
Tea: the plant and its manufacture; chemistry and consumption of the beverage.
Topics: Beverages; Caffeine; Drinking; Flavanones; Flavins; Flavonoids; Food Handling; Humans; Tea; Theobromine; Theophylline | 1984 |
Improved micro-method for the high-performance liquid chromatographic determination of caffeine and paraxanthine in biological fluids.
Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Pregnancy; Rabbits; Solvents; Spectrophotometry, Ultraviolet; Theophylline | 1984 |
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.
Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rats; Theophylline; Xanthines | 1983 |
Adenosine strongly potentiates pressor responses to nicotine in rats.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Drug Synergism; Electric Stimulation; Male; Nicotine; Phenylephrine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline | 1984 |
The pharmacological characterization of aqueous extracts of vegetable dusts.
Topics: Animals; Caffeine; Coffee; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Plant Extracts; Tea; Theophylline; Trachea | 1983 |
Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat.
Topics: Animals; Biomechanical Phenomena; Caffeine; Calcium; Female; In Vitro Techniques; Male; Muscles; Papillary Muscles; Rats; Sarcoplasmic Reticulum; Theophylline | 1983 |
Some infants receiving theophylline may have caffeine in serum.
Topics: Aminophylline; Bronchitis; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Male; Theophylline | 1983 |
Caffeine-enhanced survival of radiation-sensitive, repair-deficient Chinese hamster cells.
Topics: Animals; Caffeine; Cell Line; Cell Survival; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; DNA Repair; Neutrons; Radiation Tolerance; Theophylline | 1983 |
Influence of some common methylxanthines on contractile responses and calcium mobilization of ileal, vas deferens and bladder smooth muscle.
Topics: Animals; Caffeine; Calcium; Ileum; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Urinary Bladder; Vas Deferens; Xanthines | 1983 |
T4 levels in methylxanthine-treated premature newborns.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Retrospective Studies; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine | 1983 |
Novel form of drug-dependence--on adenosine in guinea pig ileum.
Topics: Adenosine; Animals; Caffeine; Guinea Pigs; Humans; Ileum; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Substance-Related Disorders; Theophylline | 1983 |
The bronchodilator effects and pharmacokinetics of caffeine in asthma.
Topics: Adolescent; Asthma; Bronchodilator Agents; Caffeine; Child; Double-Blind Method; Humans; Kinetics; Random Allocation; Respiratory Function Tests; Theophylline | 1984 |
Effects of dantrolene and methylxanthines on the sensory nerve terminal of the frog muscle spindle.
Topics: Animals; Axons; Caffeine; Dantrolene; Evoked Potentials; Microscopy, Electron; Neuromuscular Junction; Pentylenetetrazole; Ranidae; Theophylline; Time Factors | 1984 |
Determination of caffeine, theophylline and theobromine in serum and saliva using high-performance liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Saliva; Theobromine; Theophylline | 1984 |
Simultaneous determination of caffeine and its N-demethylated metabolites in umbilical cord plasma using high-performance liquid chromatography.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Female; Fetal Blood; Humans; Infant; Theobromine; Theophylline | 1984 |
High-performance liquid chromatographic determination of theobromine, theophylline and caffeine in food products.
Topics: Beverages; Cacao; Caffeine; Candy; Chromatography, High Pressure Liquid; Coffee; Hydrogen-Ion Concentration; Theobromine; Theophylline | 1984 |
The effect of caffeine, theophylline and amphetamine on operant responding of the mouse.
Topics: Amphetamine; Animals; Caffeine; Conditioning, Operant; Male; Mice; Mice, Inbred C57BL; Reinforcement Schedule; Theophylline | 1980 |
Automated on-line multi-dimensional high-performance liquid chromatographic techniques for the clean-up and analysis of water-soluble samples.
Topics: Body Fluids; Caffeine; Carbohydrates; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Food Analysis; Humans; Solubility; Theophylline; Vitamins; Water | 1981 |
Caffeine discrimination in the rat.
Topics: Animals; Caffeine; Conditioning, Operant; Dextroamphetamine; Generalization, Stimulus; Male; Methylphenidate; Motor Activity; Nicotine; Prejudice; Rats; Theophylline; Thyrotropin-Releasing Hormone | 1981 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Optic cup formation: a calcium-regulated process.
Topics: Animals; Caffeine; Calcimycin; Calcium; Chick Embryo; Eye; Microscopy, Fluorescence; Organ Culture Techniques; Retina; Theophylline; Trifluoperazine; Verapamil | 1982 |
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; Mice; Mice, Inbred ICR; Theobromine; Theophylline; Urethane; Xanthines | 1983 |
Theophylline-induced potentiation of the antinociceptive action of baclofen.
Topics: Analgesics; Animals; Baclofen; Caffeine; Drug Synergism; Male; Rats; Rats, Inbred Strains; Reaction Time; Theophylline | 1983 |
New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities.
Topics: Adipose Tissue; Animals; Caffeine; In Vitro Techniques; Lipolysis; Male; Norepinephrine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Disposition of caffeine and its metabolites in man.
Topics: Adult; Biotransformation; Caffeine; Female; Humans; Kinetics; Male; Theobromine; Theophylline | 1983 |
Is theophylline, aminophylline, or caffeine (methylxanthines) contraindicated in malignant hyperthermia susceptible patients?
Topics: Adolescent; Adult; Aminophylline; Caffeine; Child; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Theophylline; Xanthines | 1983 |
Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.
Topics: Apnea; Caffeine; Gestational Age; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline; Xanthines | 1983 |
Plasma xanthine levels in premature infants treated for apnoea with theophylline.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline; Xanthines | 1983 |
Crystalline anhydrous-hydrate phase changes of caffeine and theophylline in solvent-water mixtures.
Topics: Caffeine; Chemical Phenomena; Chemistry; Solubility; Solvents; Theophylline; Water | 1983 |
Inhibitory effects of methylxanthines on the activity of xanthine oxidase.
Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines | 1980 |
Regulation of human drug metabolism by dietary factors.
Topics: Adult; Antipyrine; Biotransformation; Caffeine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Half-Life; Humans; Metabolic Clearance Rate; Oxidation-Reduction; Pharmaceutical Preparations; Theobromine; Theophylline; Vegetables | 1980 |
Apnea associated with theophylline withdrawal in a term neonate.
Topics: Apnea; Caffeine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Substance Withdrawal Syndrome; Theophylline | 1982 |
Placental theophylline transfer in pregnant asthmatics.
Topics: Adolescent; Adult; Asthma; Caffeine; Female; Fetal Blood; Fetus; Half-Life; Heart; Hemodynamics; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Complications; Theophylline | 1982 |
Metabolism and distribution of labeled theophylline in the pregnant rat. Impairment of theophylline metabolism by pregnancy and absence of a blood-brain barrier in the fetus.
Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Theophylline; Tissue Distribution | 1982 |
Inhibition by theophylline of the early component of canine ventricular contraction.
Topics: Animals; Caffeine; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Stimulation, Chemical; Theophylline; Time Factors; Ventricular Function | 1982 |
Effects of caffeine, theophylline and theobromine on scheduled controlled responding in rats.
Topics: Animals; Behavior, Animal; Caffeine; Conditioning, Operant; Male; Rats; Rats, Inbred Strains; Reinforcement Schedule; Theobromine; Theophylline; Xanthines | 1982 |
Effects of methylxanthines on superprecipitation of myosin B extracted from rabbit fast skeletal muscle.
Topics: Animals; Caffeine; Chemical Precipitation; Muscle Proteins; Muscles; Myosins; Rabbits; Solubility; Theobromine; Theophylline; Xanthines | 1982 |
Sensitivity changes after morphine treatment in the mouse uterus.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Drug Tolerance; Female; In Vitro Techniques; Mice; Morphine; Naloxone; Serotonin; Theophylline; Uterine Contraction | 1982 |
Low-frequency fatigue in isolated skeletal muscles and the effects of methylxanthines.
Topics: Animals; Caffeine; Female; Mice; Muscle Contraction; Muscles; Theophylline; Xanthines | 1982 |
Sister chromatid exchanges induced by methylxanthines contained in coffee, tea and cocoa.
Topics: Animals; Bone Marrow; Caffeine; Coca; Coffee; Cricetinae; Cricetulus; Crossing Over, Genetic; Plants, Medicinal; Sister Chromatid Exchange; Tea; Theobromine; Theophylline; Xanthines | 1982 |
Massive catecholamine release from caffeine poisoning.
Topics: Adult; Affective Symptoms; Caffeine; Catecholamines; Female; Humans; Hyperglycemia; Hyperventilation; Hypokalemia; Ketone Bodies; Theophylline | 1982 |
Cross validation of serum to saliva relationships of caffeine, theophylline and total methylxanthines in neonates.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Saliva; Theophylline; Xanthines | 1982 |
Improved high-performance liquid chromatographic assay for theophylline in plasma and saliva in the presence of caffeine and its metabolites and comparisons with three other assays.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Humans; Saliva; Theophylline | 1982 |
[Pharmacologic effects of caffeine and theophylline in the premature infant].
Topics: Caffeine; Glucose; Growth; Hormones; Humans; Infant, Newborn; Infant, Premature; Respiration; Theophylline; Xanthines | 1982 |
[Use of caffeine in the treatment of apnea in premature infants].
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline; Time Factors | 1982 |
Reversed-phase liquid chromatographic investigation of UV-absorbing low-molecular-weight compounds in saliva.
Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Molecular Weight; Saliva; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Time Factors | 1982 |
Effect of serum caffeine level on pneumocardiogram of premature infants treated for apnea with theophylline.
Topics: Apnea; Caffeine; Electrocardiography; False Negative Reactions; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Respiration; Theophylline | 1982 |
Effect of caffeine, theophylline and nicotine on D-glucose and folate transport in rat jejunal brush border membrane vesicles.
Topics: Animals; Biological Transport; Caffeine; Folic Acid; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Microvilli; Nicotine; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Caffeine and theophylline: serum/CSF correlation in premature infants.
Topics: Apnea; Blood-Brain Barrier; Caffeine; Chromatography, Liquid; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline; Xanthines | 1980 |
Development of tolerance to dopaminergic stimulating effect of theophylline in mice with unilateral striatal 6-hydroxydopamine lesions.
Topics: Animals; Caffeine; Corpus Striatum; Drug Tolerance; Humans; Hydroxydopamines; Levodopa; Male; Mice; Receptors, Dopamine; Stereotyped Behavior; Theophylline | 1982 |
Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.
Topics: Acetylcholinesterase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Carbamoyl-Phosphate Synthase (Ammonia); Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Lesch-Nyhan Syndrome; Liver; Ornithine Carbamoyltransferase; Rats; Theophylline; Urea | 1982 |
Pharmacologic considerations in the therapy of neonatal apnea.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Monitoring, Physiologic; Theophylline | 1981 |
Theophylline metabolism during the first month of life and development.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Kidney; Male; Theophylline; Xanthines | 1981 |
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man.
Topics: Adult; Animals; Biotransformation; Caffeine; Humans; Macaca fascicularis; Male; Rats; Species Specificity; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines | 1981 |
In vivo N7 methylation of theophylline to caffeine in premature infants. Studies with use of stable isotopes.
Topics: Caffeine; Carbon Isotopes; Humans; Infant, Newborn; Infant, Premature; Methylation; Nitrogen Isotopes; Phenobarbital; Theophylline; Time Factors | 1981 |
Determination of plasma theophylline by straight-phase high-performance liquid chromatography: elimination of interfering caffeine metabolites.
Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Humans; Microchemistry; Theophylline | 1981 |
Effect of caffeine on circulating theophylline levels in beagle dogs.
Topics: Aminophylline; Animals; Caffeine; Dogs; Female; Injections, Intravenous; Kinetics; Male; Theophylline | 1981 |
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath; Organ Size; Rats; Theophylline | 1981 |
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factors; Species Specificity; Theophylline; Xanthines | 1981 |
[Effect of methylxanthines on urinary prostaglandin E excretion of rats acutely loaded with salt and water (author's transl)].
Topics: Animals; Caffeine; Diuresis; Electrolytes; Isotonic Solutions; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium Chloride; Theobromine; Theophylline; Water | 1981 |
Extended Hildebrand Solubility Approach: methylxanthines in mixed solvents.
Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Dioxanes; Solubility; Solvents; Theobromine; Theophylline; Water; Xanthines | 1981 |
Developmental pharmacology of the methylxanthines. Introduction.
Topics: Animals; Caffeine; Humans; Theophylline | 1981 |
Conversion of theophylline to caffeine by the human fetus.
Topics: Amniotic Fluid; Caffeine; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Infant, Premature; Mass Spectrometry; Pregnancy; Theophylline | 1981 |
Studies of caffeine and theophylline in the neonate.
Topics: Aminophylline; Amniotic Fluid; Birth Weight; Blood Transfusion; Caffeine; Fetal Blood; Fetus; Gestational Age; Humans; Infant, Newborn; Theophylline | 1981 |
Methylxanthines in serum, saliva, and spinal fluid of premature infants.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kinetics; Saliva; Theophylline | 1981 |
Adverse effects of caffeine and theophylline in the newborn infant.
Topics: Apnea; Asphyxia Neonatorum; Caffeine; Cardiovascular System; Central Nervous System; Digestive System; Hormones; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kidney; Retina; Theophylline | 1981 |
Excretion of methylxanthines in human milk.
Topics: Adult; Beverages; Caffeine; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Kinetics; Lactation; Milk, Human; Pregnancy; Saliva; Theobromine; Theophylline | 1981 |
Effects of methylxanthines on urinary prostaglandin E excretion in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electrolytes; Indomethacin; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1981 |
Binding of xanthine derivatives to human serum albumin as a function of pH.
Topics: Blood; Caffeine; Humans; Hydrogen-Ion Concentration; Serum Albumin; Theophylline | 1981 |
Twitch potentiation by rest in canine ventricular muscle: effects of theophylline.
Topics: Action Potentials; Animals; Caffeine; Calcium; Dogs; Epinephrine; Female; Gallopamil; Heart; In Vitro Techniques; Lanthanum; Male; Manganese; Myocardium; Papillary Muscles; Theophylline; Ventricular Function | 1981 |
Subchronic administration of caffeine and theophylline in drinking water: effects on rat liver RNA polymerase I activity.
Topics: Animals; Caffeine; DNA-Directed RNA Polymerases; Drinking; Hypertrophy; Liver; Male; Rats; Rats, Inbred Strains; RNA Polymerase I; Theophylline | 1981 |
Reversed-phase high-performance liquid chromatographic determination of caffeine and its N-demethylated metabolites in dog plasma.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Dogs; Male; Reference Values; Theobromine; Theophylline; Time Factors | 1981 |
Metabolism of theophylline to caffeine in adults.
Topics: Adult; Biotransformation; Caffeine; Humans; Kinetics; Male; Mathematics; Theophylline | 1981 |
[Pharmacokinetics of theophylline and caffeine in premature infants with apnea (author's transl)].
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Protein Binding; Theophylline | 1981 |
Complex interactions of caffeine and its structural analogs with ultraviolet light in cell killing.
Topics: Animals; Caffeine; Cell Line; Cell Survival; Embryo, Mammalian; Mice; Mice, Inbred C3H; Theophylline; Ultraviolet Rays; Xanthines | 1981 |
Use of salivary concentrations in the prediction of serum caffeine and theophylline concentrations in premature infants.
Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Regression Analysis; Saliva; Theophylline | 1980 |
Separation and quantitation of theophylline and paraxanthine by reversed-phase liquid chromatography.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Quaternary Ammonium Compounds; Theophylline | 1980 |
A study of caffeine in tea.
Topics: Caffeine; Methods; Tea; Theobromine; Theophylline | 1980 |
Charge transfer effect through hydrogen bonding in caffeine-p-cresol and theophylline-p-cresol complexes.
Topics: Caffeine; Chemical Phenomena; Chemistry; Cresols; Drug Interactions; Hydrogen Bonding; Spectrophotometry, Infrared; Theophylline | 1980 |
Relationship between morphological transformation and [3H]thymidine incorporation stimulated by a chemical carcinogen in postconfluent cultures of hamster embryo cells.
Topics: Animals; Autoradiography; Caffeine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Hydroxyurea; Mesocricetus; Methylnitronitrosoguanidine; Stimulation, Chemical; Theophylline; Thymidine | 1980 |
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines | 1980 |
Effects of caffeine and other substances on sodium- and calcium-independent efflux in cyanide poisoned goldfish ventricles.
Topics: Animals; Biological Transport, Active; Caffeine; Calcium; Cyanides; Goldfish; In Vitro Techniques; Myocardium; Naphazoline; Quinidine; Sarcoplasmic Reticulum; Theophylline | 1980 |
Caffeine reversal of length-dependent changes in myocardial contractile state in the cat.
Topics: Animals; Caffeine; Calcium; Cats; Dose-Response Relationship, Drug; Manganese; Myocardial Contraction; Theophylline; Time Factors; Verapamil | 1980 |
Effect of age on patterns of theophylline metabolism.
Topics: Adult; Age Factors; Aged; Biotransformation; Caffeine; Child; Child, Preschool; Cytochrome P-450 Enzyme System; Female; Humans; Infant, Newborn; Infant, Premature; Male; Metabolic Clearance Rate; Middle Aged; Regression Analysis; Theophylline | 1980 |
Study of theophylline metabolism in premature human newborns using stable isotope labelling.
Topics: Biotransformation; Caffeine; Carbon Isotopes; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Premature; Theophylline | 1980 |
The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography.
Topics: Adult; Caffeine; Child; Chromatography, High Pressure Liquid; Humans; Theobromine; Theophylline | 1980 |
[The mechanism of the chronotropic effect of caffeine and theophylline in guinea pigs].
Topics: Animals; Caffeine; Guinea Pigs; Heart Rate; In Vitro Techniques; Methyldopa; Propranolol; Reserpine; Theophylline | 1980 |
Simultaneous determination of theophylline and caffeine after extractive alkylation in small volumes of plasma by gas chromatography--mass spectrometry.
Topics: Alkylation; Apnea; Caffeine; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Theophylline | 1980 |
Simultaneous determination of dyphylline and theophylline in human plasma by high-performance liquid chromatography.
Topics: Asthma; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Reference Values; Theobromine; Theophylline | 1980 |
Characterization of the methylxanthine-induced propagated wave phenomenon in striated muscle.
Topics: Animals; Caffeine; Chick Embryo; Halothane; Histocytochemistry; Muscle Contraction; Muscles; Quinine; Theobromine; Theophylline | 1980 |
Caffeine- and aminophylline-induced seizures.
Topics: Aminophylline; Animals; Arrhythmias, Cardiac; Caffeine; Cerebral Cortex; Electrocardiography; Electroencephalography; Ethylenediamines; Injections, Intraperitoneal; Rats; Seizures; Theophylline; Time Factors | 1981 |
Histamine-evoked Ca2+ oscillations in HeLa cells are sensitive to methylxanthines but insensitive to ryanodine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biological Clocks; Caffeine; Calcium; Colforsin; HeLa Cells; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Intracellular Fluid; Ruthenium Red; Ryanodine; Theophylline | 1994 |
Caffeine-induced calcium oscillations in heavy-sarcoplasmic-reticulum vesicles from rabbit skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Hydrogen-Ion Concentration; Magnesium Chloride; Muscle Proteins; Muscles; Neomycin; Osmolar Concentration; Osmotic Pressure; Rabbits; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Temperature; Theophylline | 1994 |
Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells.
Topics: Amino Acid Oxidoreductases; Animals; Atropine; Caffeine; Calcium; Carbachol; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Gene Expression; Hydrogen-Ion Concentration; Interferon-gamma; Ionomycin; Mice; Nitric Oxide Synthase; Rats; Recombinant Proteins; RNA, Messenger; Signal Transduction; Terpenes; Thapsigargin; Theophylline; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Xanthines | 1994 |
The effect of caffeine on prostaglandin output from the guinea-pig uterus.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calmodulin; Female; Gallic Acid; Guinea Pigs; Prostaglandins; Ruthenium Red; Ryanodine; Stimulation, Chemical; Sulfonamides; Theophylline; Trifluoperazine; Uterus; Vasodilator Agents | 1994 |
IBMX induces calcium release from intracellular stores in rat sensory neurones.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline | 1995 |
Tricyclic theophylline derivatives with high water-solubility: structure-activity relationships at adenosine receptors, phosphodiesterases, and benzodiazepine binding sites.
Topics: Animals; Binding, Competitive; Caffeine; GABA-A Receptor Antagonists; Guanosine Triphosphate; In Vitro Techniques; Membranes; Phenylisopropyladenosine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P1; Solubility; Structure-Activity Relationship; Theophylline | 1995 |
Effects of methylxanthine derivatives on adriamycin concentration and antitumor activity.
Topics: Animals; Caffeine; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Synergism; Male; Mice; Pentoxifylline; Theobromine; Theophylline | 1995 |
Interference by caffeine in theophylline measurement.
Topics: Caffeine; Cross Reactions; Immunoassay; Theophylline | 1995 |
Interference by caffeine in polarization fluoroimmunoassays for theophylline.
Topics: Caffeine; Cross Reactions; Fluorescence Polarization Immunoassay; Theophylline | 1995 |
Evidence for a protective effect of theophylline and caffeine on cyclosporine-induced contractions in two in vitro glomerular models.
Topics: Animals; Caffeine; Cyclosporine; Dose-Response Relationship, Drug; Glomerular Mesangium; In Vitro Techniques; Kidney Glomerulus; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors | 1995 |
Highly sensitive and rapid determination of theophylline, theobromine and caffeine in human plasma and urine by gradient capillary high-performance liquid chromatography-frit-fast atom bombardment mass spectrometry.
Topics: Caffeine; Capillary Action; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Fast Atom Bombardment; Theobromine; Theophylline | 1995 |
Influences of immobilization and footshock stress on pharmacokinetics of theophylline and caffeine in rats.
Topics: Animals; Caffeine; Electroshock; Half-Life; Immobilization; Intestinal Absorption; Male; Rats; Rats, Wistar; Stress, Psychological; Theophylline | 1995 |
Multiple effects of caffeine on calcium current in rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium Channels; Egtazic Acid; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Theophylline | 1993 |
Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Male; Middle Aged; Oxidoreductases; Phenotype; Spectrophotometry, Ultraviolet; Theophylline; Time Factors; Uracil; Xanthines | 1995 |
Effects of xanthine derivatives in a light/dark test in mice and the contribution of adenosine receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Interactions; Light; Male; Mice; Phenethylamines; Purinergic P1 Receptor Antagonists; Structure-Activity Relationship; Theophylline; Xanthines | 1994 |
[Mutagenesis, antimutagenesis and the cellular regulatory system].
Topics: Adenosine; Antimutagenic Agents; Caffeine; Colchicine; Cyclic AMP; Mutagenesis; Plant Cells; Plants; Seeds; Theophylline | 1995 |
Development of bioreductive markers for tumour hypoxia.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Caffeine; Carcinoma; Cell Division; Cell Hypoxia; Cell Line; DNA, Neoplasm; Mice; Mice, Inbred CBA; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Theophylline; Tumor Cells, Cultured | 1995 |
Predictive steady-state chromatography. 1. Algorithms for leading and trailing edges of resolved and unresolved peaks in liquid chromatography.
Topics: Algorithms; Caffeine; Chromatography, Liquid; Computer Simulation; Models, Theoretical; Reproducibility of Results; Theophylline | 1994 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; Glutathione Transferase; Glyoxal; Liver; Liver Neoplasms; Male; Organ Size; Pyruvaldehyde; Rats; Rats, Inbred F344; Theobromine; Theophylline | 1995 |
Influence of calcium on the effects of okadaic acid and its interaction with caffeine and theophylline in rat myometrium.
Topics: Animals; Caffeine; Calcium; Colforsin; Drug Interactions; Ethers, Cyclic; Extracellular Space; Female; Intracellular Fluid; Myometrium; Okadaic Acid; Papaverine; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors; Uterine Contraction | 1994 |
[Involvement of purines in analgesia produced by weak electro-acupuncture].
Topics: Acupuncture Analgesia; Animals; Caffeine; Dipyridamole; Electroacupuncture; Pain Threshold; Purinergic P1 Receptor Antagonists; Rats; Spinal Cord; Theophylline | 1994 |
Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells.
Topics: 2-Aminopurine; Animals; Apoptosis; Caffeine; DNA Damage; Dose-Response Relationship, Radiation; G2 Phase; Kinetics; Linear Energy Transfer; Lymphoma, T-Cell; Mice; Mitosis; Theobromine; Theophylline; Tumor Cells, Cultured | 1995 |
Determination of xanthines by high-performance liquid chromatography and thin-layer chromatography in horse urine after ingestion of Guaraná powder.
Topics: Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Combinations; Horses; Regression Analysis; Reproducibility of Results; Seeds; Theobromine; Theophylline; Xanthines | 1994 |
Effects of caffeine and related methylxanthines on fetal mouse palates cultured in vitro.
Topics: Animals; Caffeine; Chi-Square Distribution; Female; Male; Mice; Mice, Inbred ICR; Organ Culture Techniques; Palate; Theobromine; Theophylline; Xanthines | 1994 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Female; Liver Neoplasms, Experimental; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains; Survival; Theophylline; Tretinoin | 1994 |
Microdialysis sampling coupled on-line to fast microbore liquid chromatography.
Topics: Acetaminophen; Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline | 1995 |
Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.
Topics: Adenosine; Animals; Bronchodilator Agents; Caffeine; Calcium; Culture Media; Dantrolene; Diaphragm; Electric Stimulation; Extracellular Space; Female; Guinea Pigs; Immunization; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Serum Albumin, Bovine; Theobromine; Theophylline; Verapamil; Xanthines | 1993 |
[Development of the method for analysis of theophylline and its related compounds using capillary high-performance liquid chromatography/fast atom bombardment-mass spectrometry].
Topics: Caffeine; Chromatography, High Pressure Liquid; Hair; Humans; Spectrometry, Mass, Fast Atom Bombardment; Theobromine; Theophylline | 1994 |
Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Caffeine; Drug Combinations; Ephedrine; Male; Osmolar Concentration; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Theophylline | 1994 |
Complexity of adjunctive pharmacological agents in ECT.
Topics: Caffeine; Electroconvulsive Therapy; Humans; Theophylline | 1994 |
Protection against methamphetamine-induced neurotoxicity to neostriatal dopaminergic neurons by adenosine receptor activation.
Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; MPTP Poisoning; Receptors, Purinergic P1; Theophylline; Tyrosine 3-Monooxygenase | 1994 |
A caffeine- and ryanodine-sensitive intracellular Ca2+ store can act as a Ca2+ source and a Ca2+ sink in PC12 cells.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Proteins; PC12 Cells; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel; Theophylline | 1994 |
Comparison of the effects of caffeine and other methylxanthines on [Ca2+]i in rat ventricular myocytes.
Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Chemical Phenomena; Chemistry, Physical; Fluorescent Dyes; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Myocardium; Rats; Solubility; Theobromine; Theophylline; Xanthines | 1994 |
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.
Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines | 1994 |
The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine.
Topics: Animals; Caffeine; Calcium Chloride; Cold Temperature; Drug Interactions; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Muscle, Smooth; Phorbol Esters; Potassium; Ryanodine; Theophylline; Trachea; Verapamil; Xanthines | 1994 |
Stress and adenosine: I. Effect of methylxanthine and amphetamine stimulants on learned helplessness in rats.
Topics: Amphetamine; Animals; Arousal; Avoidance Learning; Caffeine; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Fear; Helplessness, Learned; Male; Premedication; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Purinergic P1; Stress, Psychological; Theophylline | 1994 |
Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Avoidance Learning; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents | 1994 |
Intracellular signal transduction mechanisms of rat epididymal spermatozoa and their relationship to motility and metabolism.
Topics: Animals; Bicarbonates; Caffeine; Calcium; Carbon Dioxide; Epididymis; Glucose; In Vitro Techniques; Intracellular Fluid; Male; Nucleotides, Cyclic; Rats; Rats, Wistar; Signal Transduction; Sperm Motility; Spermatozoa; Theophylline | 1994 |
Interference by caffeine in polarization fluoroimmunoassays for theophylline in external quality assurance samples.
Topics: Artifacts; Caffeine; Fluorescence Polarization Immunoassay; Quality Control; Theophylline | 1994 |
Role of adenosine in the hypoxic ventilatory response of the newborn piglet.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Cerebrospinal Fluid; Citrates; Dipyridamole; Drug Combinations; Hypoxia; Oxygen; Purinergic P1 Receptor Antagonists; Respiration; Swine; Theophylline | 1994 |
Hepatic glutathione and lipid peroxidation in rats treated with theophylline. Effect of dose and combination with caffeine and acetaminophen.
Topics: Acetaminophen; Animals; Caffeine; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Liver; Male; Rats; Theophylline | 1994 |
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.
Topics: Administration, Oral; Animals; Caffeine; Endotoxins; Fever; Injections, Intravenous; Malaria; Male; Metabolic Clearance Rate; Plasmodium berghei; Rats; Rats, Wistar; Theobromine; Theophylline | 1993 |
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid | 1994 |
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Theobromine; Theophylline; Uric Acid | 1994 |
Alterations in theophylline metabolism during the first year of life.
Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Clearance Rate; Theophylline | 1993 |
Effect of adenosine blockade on plasma renin activity and catecholamines.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Consciousness; Epinephrine; Hydralazine; Kidney; Male; Norepinephrine; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renin; Renin-Angiotensin System; Secretory Rate; Sodium, Dietary; Theophylline; Xanthines | 1993 |
Accumulation of theophylline, theobromine and paraxanthine in the fetal rat brain following a single oral dose of caffeine.
Topics: Animals; Biotransformation; Brain; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines | 1993 |
Caffeine inhibits agonists-induced cytoplasmic Ca2+ oscillations in single rat hepatocytes.
Topics: Aequorin; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Inositol 1,4,5-Trisphosphate Receptors; Liver; Male; Periodicity; Phenylephrine; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine; Theophylline; Vasopressins | 1994 |
Caffeine tolerance in Schizosaccharomyces pombe: physiological adaptation and interaction with theophylline.
Topics: Adaptation, Physiological; Caffeine; Cell Division; Drug Interactions; Schizosaccharomyces; Theophylline | 1993 |
Enhancement of the behavioral toxicity induced by combined administration of ethanol with methylxanthines: evaluation by discrete avoidance in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Caffeine; Drug Synergism; Ethanol; Male; Mice; Mice, Inbred Strains; Theobromine; Theophylline; Xanthines | 1993 |
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices.
Topics: Action Potentials; Adenosine; Animals; Caffeine; Cell Hypoxia; Energy Metabolism; Evoked Potentials; Glucose; Glyburide; Hippocampus; Hypoglycemia; Neural Inhibition; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Tolbutamide | 1993 |
Effects of caffeine and PD 116,600 on the differential-reinforcement-of-low rate 72-S (DRL 72-S) schedule of reinforcement.
Topics: Animals; Antidepressive Agents; Caffeine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Theophylline | 1993 |
Pharmacological modulation of the spasmogenic response to methylxanthines in guinea-pig trachea.
Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Protein Kinase C; Sodium; Theophylline; Trachea; Xanthines | 1993 |
Comparison of hepatic drug-oxidizing activity after simultaneous administration of two probe drugs, caffeine and trimethadione, to human subjects.
Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Half-Life; Humans; Liver; Male; Middle Aged; Oxidation-Reduction; Oxygenases; Theobromine; Theophylline; Trimethadione | 1993 |
Excretion of caffeine and its primary degradation products into bile.
Topics: Adult; Aged; Bile; Bilirubin; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Theobromine; Theophylline; Time Factors | 1993 |
Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels. 1. Polymer composition.
Topics: Aminophylline; Biocompatible Materials; Caffeine; Diffusion; Drug Carriers; Drug Delivery Systems; Gels; Models, Chemical; Morphine; Polyethylene Glycols; Polyurethanes; Solubility; Theophylline; Water | 1993 |
Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects.
Topics: Administration, Oral; Adult; Caffeine; Drug Administration Schedule; Drug Interactions; Eating; Humans; Male; Middle Aged; Theophylline | 1993 |
HPLC determination of caffeine and theophylline by direct serum injection.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline | 1993 |
Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes.
Topics: Caffeine; Cytokines; Dexamethasone; Glucocorticoids; Humans; Interleukin-1; Interleukin-10; Leukocytes; Pentoxifylline; Streptococcus pneumoniae; Theophylline; Tumor Necrosis Factor-alpha; Xanthines | 1995 |
Adenosine antagonists potentiate D2 dopamine-dependent activation of Fos in the striatopallidal pathway.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Caffeine; Dopamine Agonists; Ergolines; Genes, fos; Globus Pallidus; Immunohistochemistry; Male; Neostriatum; Neural Pathways; Phosphodiesterase Inhibitors; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reserpine; Theobromine; Theophylline | 1995 |
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.
Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline | 1995 |
The effects of theophylline and caffeine on the isolated rat diaphragm.
Topics: Animals; Caffeine; Diaphragm; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle Fatigue; Rats; Theophylline | 1995 |
Caffeine-induced oscillations of cytosolic Ca2+ in GH3 pituitary cells are not due to Ca2+ release from intracellular stores but to enhanced Ca2+ influx through voltage-gated Ca2+ channels.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Line; Cytosol; Enzyme Inhibitors; Intracellular Fluid; Ion Channel Gating; Ionomycin; Phosphodiesterase Inhibitors; Pituitary Gland, Anterior; Rats; Terpenes; Thapsigargin; Theophylline | 1996 |
Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Glutathione; Imines; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Theophylline | 1996 |
Drug-protein interactions: two-site binding of heterocyclic ligands to a monomeric hemoglobin.
Topics: Binding Sites; Caffeine; Hemoglobins; Kinetics; Ligands; Molecular Structure; Protein Binding; Purines; Theophylline; Thermodynamics | 1996 |
Purine suppression of proliferation of Sertoli-like TM4 cells in culture.
Topics: Adenosine; Animals; Caffeine; Cell Division; Cells, Cultured; Male; Mice; Purinergic P1 Receptor Antagonists; Purines; Receptors, Purinergic P1; Sertoli Cells; Theobromine; Theophylline | 1995 |
Anxiolytic activity of adenosine receptor activation in mice.
Topics: Adenosine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Male; Maze Learning; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline | 1995 |
Inhibitors in tea of intestinal absorption of phenylalanine in rats.
Topics: Analysis of Variance; Animals; Caffeine; Cyclic AMP; Hydrolyzable Tannins; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Phenylalanine; Phosphodiesterase Inhibitors; Plant Extracts; Rats; Sodium-Potassium-Exchanging ATPase; Tea; Theophylline | 1996 |
Effect of prostaglandin F2 alpha and methylxanthines on enzymic release of bull epididymal spermatozoa in vitro.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Cattle; Dinoprost; Epididymis; Male; Sperm Motility; Spermatozoa; Theophylline; Xanthines | 1996 |
Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline | 1996 |
Pharmacokinetics of caffeine in the oestrogen-implanted ovariectomized ewe.
Topics: Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Estrus Synchronization; Female; Half-Life; Injections, Intravenous; Ovariectomy; Sheep; Theobromine; Theophylline | 1996 |
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.
Topics: 2-Chloroadenosine; Animals; Caffeine; Hemodynamics; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline | 1996 |
Adenosine A2 receptor-mediated modulation of contralateral rotation induced by metabotropic glutamate receptor activation.
Topics: Animals; Behavior, Animal; Caffeine; Cycloleucine; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Rotation; Theophylline | 1995 |
Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cyclic AMP; Fungal Proteins; Genes, Fungal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Polymerase Chain Reaction; RNA Viruses; RNA, Fungal; RNA, Messenger; Signal Transduction; Theophylline; Transcription, Genetic; Virulence; Virus Replication; Xylariales | 1996 |
Assessment of dimethylxanthine formation from caffeine in healthy adults: comparison between plasma and saliva concentrations and urinary excretion of metabolites.
Topics: Adult; Caffeine; Female; Humans; Male; Saliva; Theobromine; Theophylline | 1996 |
Simultaneous presence of cAMP and cGMP exert a co-ordinated inhibitory effect on the agonist-evoked Ca2+ signal in pancreatic acinar cells.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Mice; Pancreas; Papaverine; Phosphoric Diester Hydrolases; Signal Transduction; Theophylline | 1996 |
Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation.
Topics: Adenosine Deaminase; Animals; Biological Transport; Caffeine; Cell Division; Cell Line; Glucose; Kidney; LLC-PK1 Cells; Phenylisopropyladenosine; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Swine; Theophylline; Up-Regulation | 1996 |
Fever from caffeine.
Topics: Caffeine; Cross Reactions; Female; Fever; Humans; Middle Aged; Theophylline | 1996 |
An adenosine agonist increases blood flow and density of capillary branches in the optic tectum of Xenopus laevis tadpoles.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Capillaries; Microcirculation; Microscopy, Video; Neovascularization, Physiologic; Nitroglycerin; Regional Blood Flow; Superior Colliculi; Theophylline; Time Factors; Vasodilator Agents; Xenopus laevis | 1994 |
Overcoming of P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cells could be induced by pentoxifyline but not by theophylline and caffeine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium; Calcium Channels; Drug Interactions; Drug Resistance, Neoplasm; Leukemia L1210; Mice; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha; Vincristine | 1996 |
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels.
Topics: Age Factors; Alcohol Drinking; Aminobiphenyl Compounds; Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Coffee; Cytochrome P-450 CYP1A2; DNA Adducts; Drinking; Enzyme Induction; Glutathione Transferase; Hemoglobins; Humans; Male; Meat; Middle Aged; Nicotiana; Oxidation-Reduction; Phenotype; Plants, Toxic; Polymorphism, Genetic; Risk Factors; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms | 1996 |
Microassay of amiodarone and desethylamiodarone in serum by capillary electrophoresis with head-column field-amplified sample stacking.
Topics: Amiodarone; Caffeine; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Microchemistry; Reproducibility of Results; Theophylline | 1996 |
Theoretical relationship between the post-administration time and plasma or urinary concentration of a metabolite and the unchanged drug. Administration of caffeine to horses.
Topics: Animals; Caffeine; Horses; Substance Abuse Detection; Theophylline | 1996 |
Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Motor Neurons; Oxidopamine; Purinergic P1 Receptor Antagonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sympatholytics; Theophylline | 1996 |
Role of cyclic nucleotides in contraction induced by oxytocin in the testicular capsule of the rat in vitro.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Male; omega-N-Methylarginine; Oxytocin; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Testis; Theophylline | 1996 |
Threshold level for theophylline in doping analysis.
Topics: Caffeine; Chromatography, High Pressure Liquid; Doping in Sports; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Theophylline | 1996 |
Use of 3-(1,8-naphthalimido)propyl-modified silyl silica gel as a stationary phase for the high-performance liquid chromatographic separation of purine derivatives.
Topics: 1-Naphthylamine; Adult; Beverages; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male; Purines; Silica Gel; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tablets; Theophylline | 1996 |
Effects of caffeine and theophylline on prostaglandin production by guinea-pig endometrium.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Caffeine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Endometrium; Female; Guinea Pigs; Prostaglandins; Ryanodine; Theophylline; Time Factors | 1997 |
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine.
Topics: Animals; Caffeine; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Kidney; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Uric Acid | 1997 |
Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis.
Topics: Animals; Beverages; Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Sodium Dodecyl Sulfate; Tablets; Theobromine; Theophylline; Uric Acid | 1997 |
Theophylline has no advantages over caffeine as a putative model drug for assessing CYPIA2 activity in humans.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Male; Metabolic Clearance Rate; Methylation; Microsomes, Liver; Phosphodiesterase Inhibitors; Theophylline | 1997 |
[Development of syringe-type off line pre-column and simultaneous quantitation of four xanthine derivatives (caffeine, theobromine, theophylline and paraxanthine) in serum].
Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Theobromine; Theophylline; Xanthines | 1997 |
Inhibitory effect of methylxanthines on glycine-induced Cl current in dissociated rat hippocampal neurons.
Topics: Animals; Caffeine; Chloride Channels; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Pentoxifylline; Pyramidal Cells; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines | 1993 |
Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.
Topics: Aged; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Female; Genotype; Humans; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Saliva; Theophylline | 1996 |
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses.
Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines | 1997 |
Prostaglandin production by guinea-pig endometrial cells: effects of caffeine and other modulators of intracellular calcium.
Topics: Animals; Berberine; Caffeine; Calcium; Cell Separation; Cells, Cultured; Colforsin; Dinoprost; Drug Interactions; Endometrium; Female; Gallic Acid; Guinea Pigs; Ryanodine; Sulfonamides; Thapsigargin; Theophylline; Trifluoperazine | 1997 |
Antinociceptive effect of purine nucleotides.
Topics: Analgesics; Animals; Caffeine; Male; Mice; Naloxone; Narcotic Antagonists; Nociceptors; Purine Nucleotides; Quinidine; Receptors, Purinergic P1; Receptors, Purinergic P2; Rosaniline Dyes; Suramin; Theophylline | 1996 |
Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes.
Topics: Animals; Biotransformation; Caffeine; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Proadifen; Rats; Rats, Sprague-Dawley; Species Specificity; Theobromine; Theophylline | 1997 |
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1997 |
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA.
Topics: Bronchodilator Agents; Caffeine; Cytosine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; RNA; Sensitivity and Specificity; Theophylline | 1997 |
[Effects of beta-adrenergic agonists and phosphodiesterase inhibitors on the outflow facility of the eye].
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Caffeine; Cattle; Cells, Cultured; Dobutamine; Epinephrine; Isoproterenol; Phosphodiesterase Inhibitors; Theophylline; Trabecular Meshwork | 1997 |
Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys.
Topics: Animals; Caffeine; Equidae; Female; Horses; Male; Metabolic Clearance Rate; Species Specificity; Theobromine; Theophylline; Time Factors | 1997 |
Comparison by external quality assessment of performance of analytical systems for measurement of therapeutic drugs in serum.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography; Digoxin; Drug Monitoring; Immunoenzyme Techniques; Laboratories; Quality Control; Radioimmunoassay; Surveys and Questionnaires; Theophylline | 1997 |
Effects of chronic caffeine administration on respiration and schedule-controlled behavior in rhesus monkeys.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Female; Macaca mulatta; Male; Pyrrolidinones; Respiration; Rolipram; Theophylline | 1997 |
Protective effect of three xanthine derivatives (theophylline, caffeine and pentoxifylline) against the cyclosporin A-induced glomerular contraction in isolated glomeruli and cultured mesangial cells.
Topics: Animals; Caffeine; Cells, Cultured; Cyclosporine; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Immunosuppressive Agents; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Pentoxifylline; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines | 1997 |
Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
Topics: Acetaminophen; Animals; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Female; Gene Expression Regulation, Enzymologic; Immunoblotting; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oligonucleotide Probes; Phenotype; RNA, Messenger; Sex Factors; Theophylline | 1997 |
Interaction of oral anticoagulants with methyl xanthines.
Topics: Animals; Anticoagulants; Biological Availability; Caffeine; Central Nervous System Stimulants; Dicumarol; Drug Interactions; Male; Rabbits; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics; Warfarin; Xanthines | 1997 |
Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
Topics: Biomarkers; Blood Specimen Collection; Caffeine; Cohort Studies; Diet; Female; Humans; Mental Recall; Pregnancy; Reproducibility of Results; Theophylline | 1998 |
Functional coupling of secretion and capacitative calcium entry in PC12 cells.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Dopamine; Exocytosis; Extracellular Space; Indoles; Intracellular Fluid; PC12 Cells; Rats; Signal Transduction; Theophylline; Zinc | 1998 |
Studies on diffusion in alginate gels. II. Effect of acid and subsequent re-exposure to calcium on the diffusion of caffeine and theophylline in alginate gel films.
Topics: Administration, Oral; Alginates; Biocompatible Materials; Caffeine; Calcium; Diffusion; Gastric Acid; Gels; Glucuronic Acid; Hexuronic Acids; Pepsin A; Permeability; Solubility; Theophylline; Water | 1997 |
Evaluation of the toxicity of guarana with in vitro bioassays.
Topics: Animals; Caffeine; Cell Division; CHO Cells; Cricetinae; Drug Combinations; Indicators and Reagents; Neutral Red; Organic Chemicals; Photobacterium; Plant Extracts; Proteins; Seeds; Tetrazolium Salts; Theobromine; Theophylline | 1998 |
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Neoplasm Invasiveness; Theobromine; Theophylline; Transglutaminases; Tumor Cells, Cultured | 1998 |
Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation.
Topics: Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Perchlorates; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Theophylline | 1998 |
Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Lipolysis; Male; Medicine, Chinese Traditional; Plant Stems; Plants, Medicinal; Rats; Rats, Wistar; Theophylline | 1998 |
Effects of caffeine on lipoprotein lipase gene expression during the adipocyte differentiation process.
Topics: 3T3 Cells; Adipocytes; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Gene Expression Regulation, Enzymologic; Kinetics; Lipoprotein Lipase; Mice; RNA, Messenger; Theophylline; Time Factors; Triglycerides | 1998 |
Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice.
Topics: Animals; Blood Glucose; Caffeine; Drug Combinations; Epinephrine; Fasting; Glycogen; Male; Maltose; Mice; Physical Conditioning, Animal; Seeds; Theobromine; Theophylline | 1998 |
Functional coupling of secretion and capacitative calcium entry in PC12 cells.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Dopamine; Exocytosis; Extracellular Space; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Ion Transport; PC12 Cells; Rats; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Thapsigargin; Theophylline | 1998 |
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles | 1998 |
[Effect of caffeine and theophylline on Ca2+ sensitivity of troponin and Ca2+ release from SR in saponin-skinned rat cardiac muscle].
Topics: Animals; Caffeine; Calcium; Cardiovascular Agents; Myocardium; Rats; Saponins; Sarcoplasmic Reticulum; Stimulation, Chemical; Theophylline; Troponin | 1997 |
Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons.
Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Neostriatum; Neurons; Patch-Clamp Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Signal Transduction; Theophylline | 1998 |
Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system.
Topics: Adenosine; Animals; Biogenic Monoamines; Caffeine; Carbamazepine; Central Nervous System; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Magnesium; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Theobromine; Theophylline; Visual Cortex | 1998 |
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn; Infant, Small for Gestational Age; Male; Oxygen; Theophylline | 1998 |
Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin.
Topics: Adenosine; Animals; Antihypertensive Agents; Biological Transport; Caffeine; Central Nervous System Stimulants; Fluoxetine; Hippocampus; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quipazine; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Theobromine; Theophylline; Vasodilator Agents | 1999 |
Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat.
Topics: Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dealkylation; Dinitrobenzenes; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines | 1999 |
The effect of the aqueous solubility of xanthine derivatives on the release mechanism from ethylcellulose matrix tablets.
Topics: Algorithms; Caffeine; Cellulose; Dyphylline; Kinetics; Solubility; Spectrophotometry, Ultraviolet; Tablets; Theophylline; Xanthines | 1999 |
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines | 1999 |
Direct injection determination of theophylline and caffeine in blood serum by high-performance liquid chromatography using an ODS column coated with a zwitterionic bile acid derivative.
Topics: Bronchodilator Agents; Caffeine; Cholic Acids; Chromatography, High Pressure Liquid; Humans; Phosphodiesterase Inhibitors; Theophylline | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines | 1999 |
Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism.
Topics: Caffeine; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Delivery Systems; Humans; In Vitro Techniques; Kinetics; Molecular Mimicry; Polymers; Spectrophotometry, Ultraviolet; Theophylline | 1998 |
Development and clinical application of high performance liquid chromatography for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine.
Topics: Adolescent; Adult; Aged; Asthma; Caffeine; Child; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Humans; Male; Middle Aged; Theophylline | 1999 |
Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration.
Topics: Adenosine; Animals; Antipsychotic Agents; Behavior, Animal; Caffeine; Catalepsy; Clozapine; Corpus Striatum; Cyclic AMP; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, fos; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Second Messenger Systems; Serotonin; Serotonin Antagonists; Theophylline | 1999 |
Possible novel mechanism for bitter taste mediated through cGMP.
Topics: Aminoquinolines; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Glycine Agents; Methylene Blue; Mice; Nitro Compounds; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; Signal Transduction; Strychnine; Sulfhydryl Reagents; Taste; Theophylline | 1999 |
Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
Topics: Adult; Anthropometry; Caffeine; Coffee; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Female; Humans; Male; Reference Values; Saliva; Smoking; Theophylline; White People | 1999 |
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice.
Topics: Animals; Behavior, Animal; Caffeine; Cocaine; Extinction, Psychological; Male; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Reward; Substance Abuse, Intravenous; Theophylline; Triazoles; Xanthines | 1999 |
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline | 1999 |
Chronic effects of xanthines on levels of central receptors in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines | 1999 |
Stable isotopes labeling of drugs in pediatric clinical pharmacology.
Topics: Adolescent; Breath Tests; Caffeine; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Therapy; Helicobacter Infections; Helicobacter pylori; Human Growth Hormone; Humans; Infant; Infant, Newborn; Isotope Labeling; Pancreas; Pediatrics; Theophylline | 1999 |
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium.
Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase | 1999 |
Separation of theophylline, caffeine and related drugs by normal-phase capillary electrochromatography.
Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Electric Conductivity; Electrophoresis, Capillary; Hydrochlorothiazide; Molecular Structure; Niacin; Phenylbutazone; Theobromine; Theophylline | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Do ryanodine receptors regulate transmitter release at the neuromuscular junction of rat?
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Central Nervous System Stimulants; Gallic Acid; Membrane Potentials; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Theophylline; Xanthines | 1999 |
Extraction of purine alkaloids from maté (Ilex paraguariensis) using supercritical CO(2).
Topics: Beverages; Caffeine; Carbon Dioxide; Chromatography, High Pressure Liquid; Magnoliopsida; Pressure; Solubility; Theobromine; Theophylline | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline | 1999 |
Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.
Topics: Animals; Breeding; Caffeine; Chromosome Mapping; Cytochrome P-450 CYP1A2; Female; Genetic Markers; Genotype; Male; Mice; Mice, Inbred C3H; Multifactorial Inheritance; Phenotype; Quantitative Trait, Heritable; Sex Factors; Theophylline | 1999 |
Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion.
Topics: Abortion, Spontaneous; Adult; Caffeine; Case-Control Studies; Female; Humans; Odds Ratio; Pregnancy; Retrospective Studies; Risk Factors; Theophylline | 1999 |
Caffeine--filtering the facts.
Topics: Abortion, Spontaneous; Breast Feeding; Caffeine; Child Development; Female; Fetus; Humans; Infant; Pregnancy; Theophylline | 1999 |
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Caffeine; Catalepsy; Dopamine Agents; Hypokinesia; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Reserpine; Theophylline | 1999 |
The confirmation and control of metabolic caffeine in standardbred horses after administration of theophylline.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Doping in Sports; Female; Horses; Theophylline; Vasodilator Agents | 1999 |
Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method.
Topics: Acetaminophen; Caffeine; Chlorzoxazone; Chromatography, Thin Layer; Densitometry; Diflunisal; Dosage Forms; Naproxen; Pharmaceutical Preparations; Solvents; Theophylline | 1999 |
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.
Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Theobromine; Theophylline | 2000 |
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography. Stress test for stability evaluation.
Topics: Caffeine; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Stability; Evaluation Studies as Topic; Reproducibility of Results; Theophylline | 2000 |
Effects of caffeine and theophylline on the development of dental caries in rats.
Topics: Animals; Caffeine; Dental Caries; Female; Male; Rats; Rats, Wistar; Saliva; Stomach Ulcer; Streptococcal Infections; Streptococcus sobrinus; Theophylline | 2000 |
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Experimental; Arthrography; Caffeine; Female; Methotrexate; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Lew; Theophylline | 2000 |
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline | 2000 |
Caffeine consumption and the risk of spontaneous abortions.
Topics: Abortion, Spontaneous; Caffeine; Case-Control Studies; Female; Humans; Pregnancy; Reproducibility of Results; Retrospective Studies; Risk Factors; Smoking; Theophylline | 2000 |
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines | 2000 |
Molecular interactions and metal binding in the theophylline-binding core of an RNA aptamer.
Topics: Base Sequence; Binding Sites; Bronchodilator Agents; Caffeine; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Metals; Models, Molecular; Mutation; Nucleic Acid Conformation; Polyribonucleotides; RNA; Theophylline | 2000 |
Pharmacokinetics of theophylline and caffeine after intravenous administration of aminophylline to premature neonates in Korea.
Topics: Aminophylline; Apnea; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Korea; Male; Theophylline | 1999 |
Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Caffeine; Corpus Striatum; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Drinking; Eating; Male; Neural Pathways; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sulpiride; Syndrome; Theophylline; Xanthines | 2000 |
The pharmacokinetics, metabolism and urinary detection time of caffeine in camels.
Topics: Animals; Area Under Curve; Caffeine; Camelus; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Injections, Intravenous; Male; Protein Binding; Regression Analysis; Statistics, Nonparametric; Theobromine; Theophylline | 2000 |
Myoglobinuria after ingestion of extracts of guarana, Ginkgo biloba and kava.
Topics: Adult; Caffeine; Drug Combinations; Ginkgo biloba; Humans; Kava; Male; Myoglobinuria; Plant Extracts; Plants, Medicinal; Theobromine; Theophylline | 2000 |
Parkinson's disease and CYP1A2 activity.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Saliva; Theophylline | 2000 |
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines | 2000 |
In vivo modulation of CYP enzymes by quinidine and rifampin.
Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline | 2000 |
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines | 2000 |
Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle.
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Hindlimb; In Vitro Techniques; Intracellular Membranes; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Osmolar Concentration; Procaine; Theobromine; Theophylline | 2000 |
Characterisation of ATP-induced facilitation of transmission in rat hippocampus.
Topics: Adenosine Deaminase; Adenosine Triphosphate; Animals; Caffeine; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Synaptic Transmission; Theophylline | 2000 |
On mathematical models of microdialysis: geometry, steady-state models, recovery and probe radius.
Topics: Animals; Caffeine; Corpus Striatum; Dopamine; Male; Mathematics; Microdialysis; Models, Theoretical; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Theophylline | 2000 |
Parkinson's disease and impaired chemosensitivity to hypoxia.
Topics: Caffeine; Humans; Parkinson Disease; Phosphodiesterase Inhibitors; Respiration; Theophylline | 2000 |
Calculation of the dimensions of dosage forms with release controlled by diffusion for in vivo use.
Topics: Administration, Oral; Caffeine; Central Nervous System Stimulants; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diffusion; Drug Administration Schedule; Drug Carriers; Humans; Models, Chemical; Theophylline; Tissue Distribution; Vasodilator Agents | 2001 |
Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats.
Topics: Adenosine; Analgesics, Opioid; Animals; Caffeine; Electrophysiology; Male; Medulla Oblongata; Microinjections; Morphine; Morphine Dependence; Neurons; Purinergic P1 Receptor Agonists; Rats; Substance Withdrawal Syndrome; Theophylline | 2001 |
Adenosine induces initial hypoxic-ischemic depression of synaptic transmission in the rat hippocampus in vivo.
Topics: Acid-Base Equilibrium; Adenosine; Animals; Blood Pressure; Caffeine; Carotid Artery, Common; Constriction; Excitatory Postsynaptic Potentials; Heart Rate; Hippocampus; Hypoxia-Ischemia, Brain; Male; Oxygen; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline | 2001 |
Suspected caffeine and ephedrine toxicosis resulting from ingestion of an herbal supplement containing guarana and ma huang in dogs: 47 cases (1997-1999).
Topics: Animals; Caffeine; Central Nervous System Stimulants; Dietary Supplements; Dog Diseases; Dogs; Drug Combinations; Ephedrine; Female; Male; Phytotherapy; Retrospective Studies; Theobromine; Theophylline | 2001 |
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chromatography, Gas; Cytosol; Diet; Enzyme Inhibitors; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometry; Hypoxanthine; Male; Meat; NAD; Neoplasms; Niacinamide; Phosphodiesterase Inhibitors; Prostate; Prostatic Neoplasms; Purines; Rats; Rats, Sprague-Dawley; Spin Trapping; Temperature; Theobromine; Theophylline; Time Factors; Vasodilator Agents; Xanthine; Xanthine Oxidase | 2001 |
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.
Topics: Adenosine; Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline; Transfection | 2001 |
[Cerebral infarction in a patient consuming MaHuang extract and guarana].
Topics: Adult; Caffeine; Cerebral Angiography; Cerebral Infarction; Drug Combinations; Ephedrine; Female; Humans; Theobromine; Theophylline | 2001 |
[Use of the paraxanthine/caffeine ratio in the saliva of patients with liver cirrhosis].
Topics: Caffeine; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theophylline | 2001 |
Seizure activity and unresponsiveness after hydroxycut ingestion.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herbal; Ephedra sinica; Ephedrine; Humans; Male; Phytotherapy; Picolinic Acids; Plant Preparations; Polysaccharides; Seizures; Theobromine; Theophylline | 2001 |
[Separation of alkaloids in tea by high-speed counter-current chromatography].
Topics: Alkaloids; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Tea; Theophylline | 1998 |
Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.
Topics: Adult; Beverages; Caffeine; Drug Combinations; Fatal Outcome; Female; Food, Organic; Humans; Mitral Valve Prolapse; Theobromine; Theophylline; Ventricular Fibrillation | 2001 |
In vivo inhibition of human CYP1A2 activity by oltipraz.
Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes | 2001 |
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines | 2001 |
Glucose transporter type 1 deficiency syndrome (Glut1DS): methylxanthines potentiate GLUT1 haploinsufficiency in vitro.
Topics: 3-O-Methylglucose; Adolescent; Caffeine; Case-Control Studies; Child; Erythrocytes; Female; Humans; In Vitro Techniques; Kinetics; Male; Monosaccharide Transport Proteins; Mutation; Phenobarbital; Syndrome; Theophylline | 2001 |
Detection of small organic analytes by fluorescing molecular switches.
Topics: Allosteric Site; Base Sequence; Binding Sites; Bronchodilator Agents; Caffeine; Dose-Response Relationship, Drug; Indicators and Reagents; Models, Biological; Molecular Sequence Data; Nucleic Acid Conformation; Protein Conformation; RNA; RNA, Catalytic; Sequence Analysis; Spectrometry, Fluorescence; Structure-Activity Relationship; Theophylline; Time Factors | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].
Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 1997 |
[HPLC determination of five caffeine metabolites].
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines | 1997 |
Venom from the ectoparasitic wasp Nasonia vitripennis increases Na+ influx and activates phospholipase C and phospholipase A2 dependent signal transduction pathways in cultured insect cells.
Topics: Animals; Caffeine; Calcium; Cell Death; Cell Membrane Permeability; Cells, Cultured; Cytosol; Enzyme Inhibitors; Estrenes; Female; Intercellular Signaling Peptides and Proteins; Neomycin; Peptide Fragments; Peptides; Phospholipases A; Phospholipases A2; Pyrrolidinones; Signal Transduction; Sodium; Theophylline; Type C Phospholipases; Uteroglobin; Wasp Venoms; Wasps | 2002 |
Nanoparticles in plant extracts--factors which influence the formation of nanoparticles in black tea infusions.
Topics: Absorptiometry, Photon; Caffeine; Microspheres; Models, Molecular; Particle Size; Plant Extracts; Tea; Theobromine; Theophylline | 2001 |
Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.
Topics: Adult; Albumins; Blood Flow Velocity; Blood Glucose; Blood Volume; Brachial Artery; Caffeine; Capillaries; Female; Glucose; Humans; Insulin; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Theophylline; Xanthines | 2001 |
Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers.
Topics: Adult; Age Factors; Aged; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Theophylline; Time Factors | 2001 |
Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography.
Topics: Caffeine; Chromatography, Liquid; Food Analysis; Food Preservatives; Pharmaceutical Preparations; Spectrophotometry, Ultraviolet; Sweetening Agents; Theobromine; Theophylline | 2001 |
Maternal serum caffeine metabolites and small-for-gestational age birth.
Topics: Adult; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Risk Factors; Smoking; Theophylline | 2002 |
Effects of caffeine and its reactive metabolites theophylline and theobromine on the differentiating testis.
Topics: Animals; Caffeine; Cell Differentiation; Female; Gestational Age; Leydig Cells; Male; Maternal-Fetal Exchange; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Seminiferous Tubules; Testis; Theobromine; Theophylline | 2001 |
Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biflavonoids; Caffeine; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Ginkgo biloba; Lipolysis; Medicine, Chinese Traditional; Mice; Molecular Structure; Plant Extracts; Theophylline | 2002 |
Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography.
Topics: Beverages; Caffeine; Calibration; Chromatography, High Pressure Liquid; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 2002 |
Study of catechin and xanthine tea profiles as geographical tracers.
Topics: Caffeine; Catechin; China; Chromatography, High Pressure Liquid; Gallic Acid; India; Japan; Kenya; Sri Lanka; Tea; Theobromine; Theophylline; Xanthines | 2002 |
Continuous measurement of caffeine and two metabolites in blood and skeletal muscle of unrestrained adult horses by semi-automated in vivo microdialysis.
Topics: Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Horses; Injections, Intravenous; Microdialysis; Muscle, Skeletal; Reproducibility of Results; Theobromine; Theophylline | 2001 |
Dopaminergic mechanism for caffeine-produced cocaine seeking in rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Caffeine; Central Nervous System Stimulants; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Salicylamides; Self Administration; Theophylline; Vasodilator Agents | 2002 |
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Colorectal Neoplasms; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Theophylline; Uric Acid | 2002 |
Reverse iontophoretic monitoring in premature neonates: feasibility and potential.
Topics: Animals; Caffeine; Drug Monitoring; Ear; Electrodes; Feasibility Studies; Humans; Infant, Newborn; Infant, Premature; Iontophoresis; Models, Animal; Skin; Swine; Theophylline | 2002 |
[Application of statistical simulation spectrophotometry to the determination of four medicaments in feibaosanxiao tablets].
Topics: Acetaminophen; Caffeine; Drug Combinations; Monte Carlo Method; Phenytoin; Spectrophotometry; Tablets; Theophylline | 1998 |
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney.
Topics: Aminophylline; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Caffeine; Catalase; Cisplatin; Glutathione Peroxidase; Kidney; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Superoxide Dismutase; Theophylline; Xanthines | 2002 |
Water dynamics in channel hydrates investigated using H/D exchange.
Topics: Caffeine; Chemistry, Pharmaceutical; Cromolyn Sodium; Deuterium Oxide; Spectrum Analysis, Raman; Theophylline; Water | 2002 |
Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Humans; Mice; Phosphodiesterase Inhibitors; Species Specificity; Theophylline | 2002 |
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Deoxyglucose; Dimerization; Flavins; Glucose; Kinetics; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Recombinant Fusion Proteins; Theophylline; Transfection; Triazoles | 2002 |
Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens.
Topics: Animals; Behavior, Animal; Caffeine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Injections, Intraperitoneal; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Theophylline; Triazoles; Wakefulness | 2002 |
Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats.
Topics: Animals; Binding, Competitive; Brain; Caffeine; Down-Regulation; Female; Gestational Age; Pregnancy; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Xanthines | 2002 |
Electronic structure of some adenosine receptor antagonists. III. Quantitative investigation of the electronic absorption spectra of alkyl xanthines.
Topics: Caffeine; Purinergic P1 Receptor Antagonists; Spectrum Analysis; Theobromine; Theophylline | 2002 |
Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Differential Threshold; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Ganglionic Stimulants; Generalization, Stimulus; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Theobromine; Theophylline; Vasodilator Agents | 2002 |
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines | 2002 |
A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.
Topics: Base Pairing; Base Sequence; Binding Sites; Biosensing Techniques; Caffeine; Fluorescence Resonance Energy Transfer; Ligands; Molecular Sequence Data; Nucleic Acid Conformation; RNA; RNA, Catalytic; Sensitivity and Specificity; Theophylline | 2002 |
[Research on the separation of caffeine and its nine analogues by micellar electrokinetic capillary chromatography].
Topics: Buffers; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Hydrogen-Ion Concentration; Theophylline; Xanthines | 2002 |
[Direct determination of purine bases in tea by reversed-phase high performance liquid chromatography].
Topics: Caffeine; Chromatography, High Pressure Liquid; Tea; Theobromine; Theophylline | 1999 |
Caffeine enhances myocardial uptake of idarubicin but reverses its negative inotropic effect.
Topics: Animals; Antibiotics, Antineoplastic; Caffeine; Drug Interactions; Heart Rate; Idarubicin; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Theophylline; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure | 2003 |
Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Horses; Male; Neostriatum; Prosencephalon; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline | 2003 |
Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.
Topics: Animals; Biotransformation; Caffeine; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ellagic Acid; Enzyme Induction; Glutathione Transferase; Hydrolyzable Tannins; Hydroxybenzoates; Kidney; Liver; Male; Oxidoreductases; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines | 2003 |
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline | 2003 |
De-intercalation of ethidium bromide and acridine orange by xanthine derivatives and their modulatory effect on anticancer agents: a study of DNA-directed toxicity enlightened by time correlated single photon counting.
Topics: Acridine Orange; Antineoplastic Agents; Caffeine; DNA; Ethidium; Fluorescent Dyes; Humans; Intercalating Agents; Models, Biological; Photons; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines | 2003 |
RNA binding efficacy of theophylline, theobromine and caffeine.
Topics: Animals; Caffeine; RNA, Fungal; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline | 2003 |
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines | 2003 |
Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caffeine; Cells, Cultured; Central Nervous System Diseases; Cerebellum; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Triazines; Triazoles | 2003 |
Study on the paper substrate room temperature phosphorescence of theobromine, caffeine and theophylline and analytical application.
Topics: Aminophylline; Cacao; Caffeine; Coffee; Hydrogen-Ion Concentration; Luminescence; Metals, Heavy; Paper; Spectrometry, Fluorescence; Tea; Temperature; Theobromine; Theophylline | 2003 |
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Topics: Animals; Blotting, Western; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Dietary Supplements; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Male; Microsomes, Liver; Obesity; Plant Extracts; Rats; Rats, Sprague-Dawley; Smoking; Theophylline | 2003 |
Selective solid-phase extraction sorbent for caffeine made by molecular imprinting.
Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Humans; Hydrogen-Ion Concentration; Polymers; Theobromine; Theophylline | 2002 |
Acute caffeine treatment increases extracellular nucleotide hydrolysis from rat striatal and hippocampal synaptosomes.
Topics: Adenine Nucleotides; Animals; Caffeine; Extracellular Space; Hippocampus; Male; Rats; Rats, Wistar; Synaptosomes; Theophylline | 2003 |
Simultaneous determination of theophylline and caffeine by proton magnetic resonance spectroscopy using partial least squares regression techniques.
Topics: Caffeine; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Tablets; Theophylline | 2003 |
Repeatability and reproducibility of high concentration data in reversed-phase liquid chromatography. I. Overloaded band profiles on Kromasil-C18.
Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Indicators and Reagents; Mathematics; Phenol; Propranolol; Reproducibility of Results; Theophylline | 2003 |
Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects.
Topics: Adult; Caffeine; Carbon Dioxide; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Middle Aged; Polycyclic Aromatic Hydrocarbons; Theophylline; Vehicle Emissions | 2003 |
Interaction of metal ions with caffeine and theophylline: stability and structural features.
Topics: Caffeine; Ions; Metals; Molecular Structure; Solutions; Spectroscopy, Fourier Transform Infrared; Theophylline | 2003 |
The effect of theophylline with ethylenediamine (aminophylline) and caffeine on cerebral hemodynamics and cerebrospinal fluid pressure in patients with hypertensive headaches.
Topics: Aminophylline; Caffeine; Cerebrospinal Fluid Pressure; Ethylenediamines; Headache; Hemodynamics; Humans; Hypertension; Theophylline | 1952 |
The action of solubilizing agents on the solubility of xanthine derivatives in water. I. The application of partition studies to theophylline and caffeine combinations.
Topics: Caffeine; Diuretics; Solubility; Theophylline; Water; Xanthines | 1952 |
The action of solubilizing agents on the solubility of xanthine derivatives in water. II. The application of conductimetric titrations to the study of xanthine combinations.
Topics: Caffeine; Diuretics; Solubility; Theobromine; Theophylline; Water; Xanthine; Xanthines | 1952 |
The action of solubilizing agents on the solubility of xanthine derivatives in water. III. The application of cryoscopy to the study of caffeine, theophylline, and theobromine with solubilizing agents.
Topics: Caffeine; Diuretics; Solubility; Theobromine; Theophylline; Water; Xanthines | 1952 |
The metabolism of caffeine and theophylline.
Topics: Body Fluids; Caffeine; Humans; Theophylline; Uric Acid; Urine | 1953 |
Growth promotion in carnivorous protozoa by substituted purines.
Topics: Animals; Caffeine; Eukaryota; Guanine; Humans; Invertebrates; Purines; Theobromine; Theophylline | 1953 |
Toxicity of caffeine, theobromine and theophylline.
Topics: Caffeine; Diuretics; Humans; Theobromine; Theophylline | 1953 |
Study of possible complex formation between macromolecules and certain pharmaceuticals. I. Polyvinylpyrrolidone with sulfathiazole, procaine hydrochloride, sodium salicylate, benzyl penicillin, chloramphenicol, mandelic acid, caffeine, theophylline, and c
Topics: Caffeine; Chloramphenicol; Cortisone; Mandelic Acids; Penicillin G; Povidone; Procaine; Sodium Salicylate; Sulfathiazole; Sulfathiazoles; Theophylline | 1954 |
[The effects of pervitin, arterenol, caffeine, euphyllin, cordalin and strophanthin on renal function].
Topics: Aminophylline; Amphetamine; Amphetamines; Caffeine; Kidney Function Tests; Norepinephrine; Strophanthins; Theophylline; Urinary Tract Physiological Phenomena | 1954 |
Investigation of complexes formed in solution by caffeine. VI. Comparison of complexing behaviors of methylated xanthines with p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, and p-hydroxybenzoic acid.
Topics: 4-Aminobenzoic Acid; Aspirin; Benzoates; Caffeine; Hydroxybenzoates; Pharmaceutical Solutions; Salicylic Acid; Solutions; Theobromine; Theophylline; Xanthines | 1954 |
Action of purine alkaloids and caffeine drugs on hyaluronidase.
Topics: Caffeine; Coffee; Hyaluronoglucosaminidase; Plants; Tea; Theobromine; Theophylline | 1954 |
[Studies on coronary-dilatating effects on Langendorff's preparation and its interpretation on the basis of competitive antagonism].
Topics: Caffeine; Cardiomegaly; Heart; Humans; Khellin; Papaverine; Theophylline | 1954 |
[The effects of caffeine and theophylline on the myocardium].
Topics: Caffeine; Heart; Humans; Myocardium; Theophylline | 1955 |
[Effect of theophylline, caffeine and theobromine on contraction force, excitability refractory period and spontaneous frequency in isolated cat myocardium].
Topics: Animals; Caffeine; Cats; Felis; Heart; Myocardium; Theobromine; Theophylline | 1956 |
[Contractile action of methylxanthines].
Topics: Caffeine; Humans; Muscle Contraction; Theobromine; Theophylline; Xanthines | 1957 |
A study of the metabolism of theobromine, theophylline, and caffeine in man.
Topics: Body Fluids; Caffeine; Humans; Male; Theobromine; Theophylline | 1957 |
Complexes formed in solution by homologs of caffeine; interactions between p-hydroxybenzoic acid and ethyl, propyl, and butyl derivatives of theobromine, and theophylline.
Topics: Caffeine; Hydroxybenzoates; Pharmaceutical Solutions; Solutions; Theobromine; Theophylline | 1957 |
[Experiences with the antiemetic rodavan in prevention and therapy of postanesthesia vomiting].
Topics: Antiemetics; Biomedical Research; Caffeine; Diphenhydramine; Surgical Procedures, Operative; Theophylline; Vomiting | 1958 |
[Clinical experience with the antiemetic rodavan in the therapy of roentgen intoxication].
Topics: Antiemetics; Caffeine; Diphenhydramine; Radiation Injuries; Radiotherapy; Theophylline | 1958 |
8-(Dialkylaminoalkylamino)-caffeines as potential pharmacodynamic agents.
Topics: Caffeine; Theophylline | 1959 |
[Treatment of insomnia in asthmatics with hypnasmine].
Topics: Asthma; Barbiturates; Caffeine; Humans; Sleep Initiation and Maintenance Disorders; Theophylline | 1960 |
[The action of caffeine, theobromine and theophylline on the isolated phrenicus-diaphragm preparation of the rat in different extracellular concentrations of potassium and calcium ions].
Topics: Abdominal Muscles; Animals; Caffeine; Calcium; Calcium, Dietary; Diaphragm; Ions; Muscles; Potassium; Rats; Theobromine; Theophylline | 1961 |
Common drugs that may invalidate spectrophotofluorometric assays of blood griseofulvin.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Biological Assay; Caffeine; Griseofulvin; Humans; Quinine; Theophylline | 1962 |
Interaction of carrageenan and other hydrocolloids with alkaloids. II. Equilibrium dialysis studies.
Topics: Acacia; Alkaloids; Atropa belladonna; Caffeine; Carrageenan; Colloids; Dialysis; Methylcellulose; Parasympatholytics; Pectins; Polysaccharides; Quinine; Renal Dialysis; Resins, Synthetic; Theophylline | 1962 |
[Studies on the coulometric determination of caffeine, theobromine and theophylline. I. Chlorocoulometric microdetermination of caffeine].
Topics: Caffeine; Theobromine; Theophylline | 1963 |
[Some possibilities for the use of thin-layer chromatography without binding agents in drug analysis. 3. Qualitative detection of purines and barbiturates used in prescriptions].
Topics: Aminophylline; Barbiturates; Caffeine; Chromatography, Thin Layer; Phenobarbital; Purines; Substance Abuse Detection; Theobromine; Theophylline | 1963 |
[Theomyl, a new synthetic asthma preparation].
Topics: Albuterol; Asthma; Caffeine; Epinephrine; Ipratropium; Theophylline | 1962 |
[On the effect of caffeine and theophylline on the fatigued rat diaphragm preparation].
Topics: Animals; Caffeine; Diaphragm; Fatigue; Neuromuscular Junction; Rats; Theophylline | 1962 |
DISSOLUTION BEHAVIOR OF CRYSTALLINE SOLVATED AND NONSOLVATED FORMS OF SOME PHARMACEUTICALS.
Topics: Caffeine; Chemistry, Pharmaceutical; Cholesterol; Fludrocortisone; Glutethimide; Pharmacy; Research; Solubility; Sulfathiazoles; Theophylline | 1963 |
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE.
Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines | 1963 |
STUDIES ON THE METHOD OF THERMAL ANALYSIS OF ORGANIC MEDICINALS. III. RELATIONS BETWEEN METHODS OF SAMPLE PREPARATION AND OBTAINED PHASE DIAGRAMS.
Topics: 4-Aminobenzoic Acid; Aminopyrine; Ammonium Compounds; Aniline Compounds; Barbiturates; Benzoates; Biphenyl Compounds; Caffeine; Chemistry Techniques, Analytical; Niacinamide; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Research; Theophylline | 1963 |
[STUDY OF THE INTERMEDIATE METABOLISM OF DRUGS USING PARTIAL HEPATECTOMY].
Topics: Barbiturates; Caffeine; Chemical and Drug Induced Liver Injury; Chloralose; Hepatectomy; Hepatitis; Hypnotics and Sedatives; Insulin; Liver; Meperidine; Muscle Relaxants, Central; Pentylenetetrazole; Rats; Research; Splenectomy; Theophylline; Toxicology; Tranquilizing Agents; Urethane | 1963 |
[EFFECTS OF VARIOUS NATURAL ORGANIC SUBSTANCES AND AMINO ACIDS ON THE BLOOD SURGAR LEVEL AND EXPERIMENTAL STUDIES ON ORAL HYPOGLYCEMIC AGENTS].
Topics: Amino Acids; Animals; Bile Acids and Salts; Blood Chemical Analysis; Blood Glucose; Caffeine; Chlorpropamide; Creatine; Creatinine; Cystine; Diabetes Mellitus, Experimental; Hippurates; Hypoglycemic Agents; Injections; Injections, Intravenous; Metformin; Pathology; Pharmacology; Rats; Research; Salts; Theobromine; Theophylline; Tyrosine | 1963 |
MUTATIONAL SYNERGISM BETWEEN RADIATIONS AND METHYLATED PURINES IN ESCHERICHIA COLI.
Topics: Caffeine; Escherichia coli; Light; Mutation; Pharmacology; Purines; Research; Streptomycin; Theobromine; Theophylline; Ultraviolet Rays | 1964 |
[INCIDENTS IN REID'S INTRACISTERNAL THERAPY WITH PROCAINE-CAFFEINE MIXTURES].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Caffeine; Encephalomyelitis; Epilepsy; Headache; Injections; Injections, Spinal; Jurisprudence; Neurologic Manifestations; Procaine; Spinal Diseases; Strophanthins; Subarachnoid Space; Theophylline; Therapeutics; Toxicology | 1963 |
DEMETHYLATION OF PURINE ANALOGS BY MICROSOMAL ENZYMES FROM MOUSE LIVER.
Topics: Animals; Antimetabolites; Caffeine; Carcinoma; Carcinoma, Ehrlich Tumor; Liver; Mercaptopurine; Metabolism; Mice; Purines; Pyrimidines; Research; Sulfhydryl Compounds; Theobromine; Theophylline | 1964 |
[ON ISOLATED ALLERGIC MYOCARDITIS].
Topics: Asthma; Bronchitis; Caffeine; Cardiac Complexes, Premature; Drug Therapy; Electrocardiography; Epinephrine; Geriatrics; Goiter; Graves Disease; Hypertension; Myocarditis; Theophylline | 1964 |
THE ANTI-ANAPHYLACTIC ACTIVITY OF THEOPHYLLINE AND SOME RELATED XANTHINE DERIVATIVES.
Topics: Anaphylaxis; Anti-Allergic Agents; Caffeine; Diuretics; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Lipids; Lung; Pharmacology; Research; Theobromine; Theophylline; Xanthine; Xanthines | 1964 |
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES.
Topics: Caffeine; Guanine; Guanine Nucleotides; Hydrogen-Ion Concentration; Hypoxanthines; Infrared Rays; Light; Manometry; Methylene Blue; Nucleosides; Oxidation-Reduction; Purines; Research; Theobromine; Theophylline; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uric Acid; Xanthines | 1964 |
ACTIVATION OF AN EPINEPHRINE-SENSITIVE LIPOLYTIC ACTIVITY FROM ADIPOSE TISSUE BY ADENOSINE 3',5'-PHOSPHATE.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adipose Tissue; Caffeine; Calcium; Epididymis; Epinephrine; Humans; Lipid Metabolism; Lipolysis; Male; Pharmacology; Phosphates; Rats; Research; Theophylline | 1964 |
POTENTIATION OF DIURETIC EFFECTS OF METHYL XANTHINES AND PYRIMIDINES BY CARBONIC ANHYDRASE INHIBITORS.
Topics: Acetazolamide; Aminophylline; Animals; Caffeine; Carbonates; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chlorine; Diuretics; Dogs; Enzyme Inhibitors; Hydrochlorothiazide; Kidney; Pharmacology; Physiology; Potassium; Pyrimidines; Research; Sodium; Sulfonamides; Theophylline; Water-Electrolyte Balance; Xanthines | 1964 |
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID].
Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology | 1964 |
MECHANISM OF MELANOPHORE DISPERSION.
Topics: Adrenocorticotropic Hormone; Animals; Anura; Arsenicals; Benzoates; Caffeine; Calcium Chloride; Chromatophores; Cyanides; Fluoroacetates; Glyceraldehyde; Iodoacetates; Melanocyte-Stimulating Hormones; Melanophores; Mercury; Norepinephrine; Pharmacology; Pigmentation; Potassium; Research; Theobromine; Theophylline | 1964 |
DARK REPAIR OF UV INDUCTION IN K12 (LAMBDA).
Topics: Acridines; Caffeine; Coliphages; DNA; DNA, Viral; Escherichia coli; Mutation; Pharmacology; Proteins; Purines; Radiation Genetics; Research; RNA; RNA, Viral; Theophylline; Ultraviolet Rays | 1964 |
THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM.
Topics: Caffeine; Calcium Chloride; Carbohydrate Metabolism; Diaphragm; Dopamine; Ephedrine; Epinephrine; Glucagon; Hexosephosphates; Insulin; Iodoacetates; Isoproterenol; Muscle, Smooth; Muscles; Norepinephrine; Pharmacology; Phlorhizin; Rats; Research; Sympathomimetics; Theophylline; Tyramine | 1964 |
[TETRONIC ACIDS. 4. TETRONIC ACID DERIVATIVES AS SOLVENTS FOR DRUGS DIFFICULT TO DISSOLVE IN WATER].
Topics: Caffeine; Chemistry, Pharmaceutical; Furans; Khellin; Pyrazoles; Research; Solubility; Solvents; Steroids; Theophylline; Water | 1963 |
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists; Mice; Piperidines; Pregnancy; Pregnancy, Animal; Research; Thalidomide; Theophylline; Toxicology | 1964 |
ASSIGNMENT OF THE N-METHYL HYDROGEN NMR PEAKS OF CAFFEINE.
Topics: Caffeine; Chemistry, Pharmaceutical; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pharmacy; Research; Theobromine; Theophylline | 1964 |
EFFECT OF XANTHINES AND HISTAMINE ON ION TRANSPORT AND RESPIRATION BY FROG GASTRIC MUCOSA.
Topics: Anura; Caffeine; Chlorides; Epithelium; Fatty Acids; Gastric Juice; Gastric Mucosa; Glucuronates; Histamine; Ion Exchange; Ion Transport; Metabolism; Muscle, Smooth; Pharmacology; Research; Stomach; Theobromine; Theophylline; Xanthines | 1965 |
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. V. CHLOROCOULOMETRIC MICRODETERMINATION OF THEOPHYLLINE AFTER ALKALINE HYDROLYSIS].
Topics: Caffeine; Hydrolysis; Research; Theobromine; Theophylline | 1964 |
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. VI. CHLOROCOULOMETRIC MICRODETERMINATION OF COMPONENTS IN A MIXTURE OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE].
Topics: Caffeine; Research; Theobromine; Theophylline | 1964 |
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. 3. CHLORO-COULOMETRIC MICRODETERMINATION OF CAFFEINE AFTER ITS ALKALINE HYDROLYSIS WITH THE USE OF 2 METHODS].
Topics: Caffeine; Chemistry Techniques, Analytical; Hydrolysis; Microchemistry; Research; Theobromine; Theophylline | 1964 |
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. IV. BROMO-COULOMETRIC MICRODETERMINATION OF CAFFEINE AFTER ALKALINE HYDROLYSIS].
Topics: Caffeine; Chemistry Techniques, Analytical; Hydrolysis; Microchemistry; Research; Theobromine; Theophylline | 1964 |
EFFECT OF NATURALLY OCCURRING XANTHINES ON BACTERIA. I. ANTIMICROBIAL ACTION AND POTENTIATING EFFECT ON ANTIBIOTIC SPECTRA.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacillus subtilis; Bacteria; Caffeine; Candida; Citrates; Corynebacterium diphtheriae; Enterobacter; Enterobacter aerogenes; Escherichia coli; Klebsiella; Mycobacterium; Pharmacology; Proteus; Pseudomonas aeruginosa; Research; Salmonella paratyphi A; Salmonella typhi; Sarcina; Shigella dysenteriae; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline; Theobromine; Theophylline; Xanthines | 1965 |
THE EFFECTS OF THE ELECTRICAL STIMULATION OF THE BRACHIAL PLEXUS ON THE POTENTIAL DIFFERENCE OF FROG SKIN.
Topics: Acetazolamide; Acetylcholine; Animals; Anura; Arginine Vasopressin; Atropine; Brachial Plexus; Caffeine; Cocaine; Electric Stimulation; Electrophysiology; Epinephrine; Neostigmine; Norepinephrine; Papaverine; Pharmacology; Physostigmine; Pilocarpine; Research; Skin; Theophylline; Tubocurarine; Vasopressins | 1965 |
[Henodynamic effect of purine bodies in unanesthetized dog; comparative studies on caffeine, theobromine, theophylline, euphylline, hydroxyethyltheophylline and dihydroxypropyltheophylline].
Topics: Aminophylline; Animals; Caffeine; Dogs; Dyphylline; Ethylenediamines; Purines; Theobromine; Theophylline; Xanthines | 1955 |
[Prophylaxis and therapy of postoperative vomiting with the diphenhydramine derivative combination Rodavan; a clinical-statistical evaluation].
Topics: Caffeine; Diphenhydramine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Theophylline; Vomiting | 1961 |
Regarding "An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years".
Topics: Abortion, Spontaneous; Adult; Bias; Caffeine; Female; Humans; Pregnancy; Risk Factors; Sodium; Specimen Handling; Theophylline; Time Factors | 2004 |
Repeatability and reproducibility of high-concentration data in reversed-phase liquid chromatography. III. Isotherm reproducibility on Kromasil C18.
Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chromatography, Liquid; Phenol; Propranolol; Reproducibility of Results; Theophylline; Thermodynamics | 2004 |
[Comparison of the effect of some puric alkaloids (caffeine, theobromine, theophylline and theophylline-ethylenediamine) on cholinesterase].
Topics: Alkaloids; Aminophylline; Caffeine; Cholinesterases; Humans; Theobromine; Theophylline | 1950 |
Comments on the paper: Effect and specificity of certain histamine antagonists studied on the isolated small intestine of the guinea-pig by L. C. Grandjean.
Topics: Caffeine; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Intestine, Small; Intestines; Theophylline | 1951 |
The effect of methylxanthines on the hypocoagulability induced by chloroform in the dog.
Topics: Animals; Caffeine; Chloroform; Dogs; Hemostatics; Prothrombin; Theobromine; Theophylline; Xanthines | 1952 |
Component analysis of illicit heroin samples with GC/MS and its application in source identification.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Codeine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Heroin; Illicit Drugs; Morphine Derivatives; Narcotics; Theophylline; Vasodilator Agents | 2004 |
Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Time; Xanthines | 2004 |
Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography.
Topics: Automation; Caffeine; Chromatography, High Pressure Liquid; Polymers; Theobromine; Theophylline | 2004 |
Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography.
Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Reference Standards; Theobromine; Theophylline | 2004 |
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
Topics: Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fluoresceins; Humans; Organic Anion Transporters; Theophylline; Xanthines | 2004 |
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.
Topics: Adult; Caffeine; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-10; Interleukin-12; Lipopolysaccharides; Theophylline; Tumor Necrosis Factor-alpha | 2004 |
Simultaneous determination of caffeine, theophylline and theobromine in human plasma by on-line solid-phase extraction coupled to reversed-phase chromatography.
Topics: Buffers; Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methanol; Phosphates; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Theobromine; Theophylline | 2004 |
[Methylxanthines in the group of potassium sensitizers].
Topics: Caffeine; Humans; Nervous System Physiological Phenomena; Physiology; Potassium; Theobromine; Theophylline; Xanthines | 1950 |
Genetic screens and selections for small molecules based on a synthetic riboswitch that activates protein translation.
Topics: 5' Untranslated Regions; Caffeine; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Messenger; Theophylline; Xanthines | 2004 |
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Synaptic Transmission; Theophylline | 2004 |
Vibrational spectral investigation on xanthine and its derivatives--theophylline, caffeine and theobromine.
Topics: Caffeine; Carbon; Hydrogen; Kinetics; Molecular Structure; Nitrogen; Oxygen; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theobromine; Theophylline; Vibration; Xanthines | 2005 |
Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine.
Topics: Anesthesia; Animals; Caffeine; Diuretics; Genotype; Glomerular Filtration Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Natriuresis; Potassium; Receptor, Adenosine A1; Sodium; Theophylline; Urodynamics | 2005 |
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Intraperitoneal; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines | 2005 |
Effect of caffeine on cerebral blood flow response to somatosensory stimulation.
Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation; Electric Stimulation; Injections, Intravenous; Male; Physical Stimulation; Pia Mater; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Somatosensory Cortex; Theophylline; Vasodilation; Vasodilator Agents | 2005 |
Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain.
Topics: Adenosine A1 Receptor Antagonists; Adenylyl Cyclases; Animals; Brain; Caffeine; Female; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptor, Adenosine A1; Theophylline | 2005 |
Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Riluzole; Theophylline | 2005 |
Stabilizing effects of extracellular ATP on synaptic efficacy and plasticity in hippocampal pyramidal neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Caffeine; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Extracellular Space; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Purinergic P2 Receptor Antagonists; Pyramidal Cells; Pyridoxal Phosphate; Rats; Rats, Wistar; Synaptic Transmission; Theophylline; Time Factors | 2005 |
Raman spectroscopic characterisations and analytical discrimination between caffeine and demethylated analogues of pharmaceutical relevance.
Topics: Alkaloids; Caffeine; Models, Chemical; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline; Xanthine | 2005 |
Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.
Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line; Cells, Cultured; DNA-Binding Proteins; HIV-1; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Theophylline; Time Factors; Tumor Suppressor Proteins; Virus Replication; Xanthines | 2005 |
Monitoring bronchodilators with direct injection.
Topics: Bronchodilator Agents; Caffeine; Calibration; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline | 2005 |
Inhibition of human TREK-1 channels by caffeine and theophylline.
Topics: Animals; Caffeine; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Mutation; Potassium Channels, Tandem Pore Domain; Theophylline | 2005 |
Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Escherichia coli; Female; Genotype; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Theophylline | 2005 |
Effect of chronic gestational treatment with caffeine or theophylline on Group I metabotropic glutamate receptors in maternal and fetal brain.
Topics: Animals; Blotting, Western; Brain; Caffeine; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Methoxyhydroxyphenylglycol; Phosphodiesterase Inhibitors; Phospholipase C beta; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Type C Phospholipases | 2005 |
Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone.
Topics: Antimutagenic Agents; Caffeine; Cell Survival; Daunorubicin; Doxorubicin; Mitoxantrone; Mutagenicity Tests; Pentoxifylline; Structure-Activity Relationship; Theophylline; Vibrio; Xanthenes | 2005 |
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene | 2005 |
Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites.
Topics: Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Cricetulus; Humans; Molecular Structure; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Theobromine; Theophylline; Uric Acid; Xanthines | 2005 |
Study for luminescence performance of three methyl xanthine derivatives.
Topics: Caffeine; Fluorescence; Hydrogen-Ion Concentration; Luminescent Measurements; Molecular Structure; Spectrometry, Fluorescence; Temperature; Theobromine; Theophylline; Xanthines | 2005 |
Comment on vibrational spectral investigation on xanthine and its derivatives-theophylline, caffeine and theobromine.
Topics: Caffeine; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theobromine; Theophylline; Vibration | 2005 |
Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.
Topics: Animals; Caffeine; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Theophylline; Transcription Factor AP-1 | 2005 |
Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats.
Topics: Animals; Blood Glucose; Body Weight; Caffeine; Deoxyglucose; Eating; Feeding Behavior; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Theophylline; Xanthenes | 1977 |
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; Animals; Butadienes; Caffeine; Female; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Purines; Rabbits; Receptors, Purinergic P1; Theophylline; Wortmannin; Xanthines | 2006 |
A structural study of new potent and selective antagonists to the A2B adenosine receptor.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Asparagine; Caffeine; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Histidine; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Theophylline; Xanthines | 2005 |
Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells.
Topics: 1-Methyl-4-phenylpyridinium; Caco-2 Cells; Caffeine; Catechin; Corticosterone; Food-Drug Interactions; Humans; Intestinal Absorption; Intestinal Mucosa; Organic Cation Transport Proteins; Plant Extracts; Quinolines; Tea; Theophylline; Tritium | 2005 |
Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans.
Topics: Adult; Antimalarials; Antinematodal Agents; Area Under Curve; Artemisinins; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Mass Spectrometry; Middle Aged; Theophylline; Thiabendazole | 2005 |
Separation of caffeine and theophylline in poly(dimethylsiloxane) microchannel electrophoresis with electrochemical detection.
Topics: Animals; Caffeine; Dimethylpolysiloxanes; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Reproducibility of Results; Sensitivity and Specificity; Theophylline | 2005 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Caffeine; Cytochrome P-450 CYP1A2; Delayed-Action Preparations; Female; Genotype; Humans; Japan; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Pulmonary Disease, Chronic Obstructive; Smoking; Theophylline | 2006 |
Spectrophotometric determination of caffeine and theophylline in pure alkaloids and its application in pharmaceutical formulations.
Topics: Alkaloids; Caffeine; Pharmaceutical Preparations; Reproducibility of Results; Spectrophotometry; Tablets; Theophylline | 2006 |
Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminoacridines; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Caffeine; Central Nervous System Stimulants; Doxorubicin; Free Radical Scavengers; Mutagenicity Tests; Neurotoxins; Nitrogen Mustard Compounds; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Vibrio | 2006 |
Serum sickness-like reaction to Pamabrom.
Topics: Adult; Arm; Aspirin; Caffeine; Diagnosis, Differential; Drug Combinations; Ephedrine; Female; Humans; Leg; Phenacetin; Propanolamines; Serum Sickness; Theophylline | 2006 |
In vitro transdermal delivery of caffeine, theobromine, theophylline and catechin from extract of Guarana, Paullinia Cupana.
Topics: Adhesives; Administration, Cutaneous; Animals; Caffeine; Catechin; In Vitro Techniques; Paullinia; Plant Extracts; Polyethylene Glycols; Propylene Glycol; Skin; Skin Absorption; Swine; Theobromine; Theophylline; Water | 2006 |
Differential effect of selected methylxanthine derivatives on radiosensitization of lung carcinoma cells.
Topics: Apoptosis; Caffeine; Carcinoma, Large Cell; Cell Line, Tumor; Cell Survival; Flow Cytometry; Gamma Rays; Humans; Lung Neoplasms; Radiation-Sensitizing Agents; Theophylline; Xanthines | 2006 |
Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.
Topics: Adult; Biomarkers; Caffeine; Chi-Square Distribution; Connecticut; Cytochrome P-450 Enzyme System; Female; Fetal Blood; Fetal Growth Retardation; Humans; Massachusetts; Maternal-Fetal Exchange; Mothers; Pregnancy; Pregnancy Outcome; Risk Factors; Statistics, Nonparametric; Theobromine; Theophylline | 2006 |
Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.
Topics: Abdominal Fat; Animals; Body Weight; Caffeine; Cholesterol; Diet; Dietary Fats; Eating; Liver; Male; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Triglycerides; Xanthines | 2006 |
Application of a sample pooling method for the accelerated assessment of the rate of uptake of drugs by the brain in rats.
Topics: Animals; Brain; Caffeine; Male; Metabolic Clearance Rate; Microdialysis; Rats; Rats, Sprague-Dawley; Theophylline | 2006 |
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines | 2006 |
Enzymatic erosion of bioartificial membranes to control drug delivery.
Topics: Biocompatible Materials; Buffers; Caffeine; Chemistry, Pharmaceutical; Cross-Linking Reagents; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Membranes, Artificial; Microscopy, Electron, Scanning; Polyvinyl Alcohol; Solubility; Solutions; Starch; Temperature; Theophylline; Water | 2006 |
Fluid bed drying of guarana (Paullinia cupana HBK) extract: effect of process factors on caffeine content.
Topics: Caffeine; Desiccation; Drug Compounding; Plant Extracts; Rheology; Theobromine; Theophylline | 2006 |
[Study on interaction of caffeine and theophylline with bovine serum albumins].
Topics: Animals; Caffeine; Cattle; Central Nervous System Stimulants; Kinetics; Protein Binding; Serum Albumin, Bovine; Spectrometry, Fluorescence; Theophylline; Vasodilator Agents | 2006 |
Characteristics of thiamine uptake by the BeWo human trophoblast cell line.
Topics: Biological Transport; Caffeine; Cell Line, Tumor; Cell Membrane Structures; Ethanol; Female; Flavonoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Phenols; Placenta; Polyphenols; Pregnancy; Serotonin Plasma Membrane Transport Proteins; Temperature; Theophylline; Thiamine; Trophoblasts | 2006 |
Computationally-assisted approach to the vibrational spectra of molecular crystals: study of hydrogen-bonding and pseudo-polymorphism.
Topics: Caffeine; Computer Simulation; Crystallization; Hydrogen Bonding; Models, Molecular; Molecular Structure; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline; Vibration | 2006 |
Characteristic of theophylline imprinted monolithic column and its application for determination of xanthine derivatives caffeine and theophylline in green tea.
Topics: Adsorption; Caffeine; Polymers; Tea; Temperature; Theophylline; Thermodynamics | 2006 |
A simple fluorescent biosensor for theophylline based on its RNA aptamer.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; DNA; Dose-Response Relationship, Drug; Fluorescent Dyes; Models, Chemical; Nucleic Acid Conformation; Nucleic Acid Hybridization; RNA; Spectrometry, Fluorescence; Temperature; Theophylline | 2006 |
Characterization of anhydrous and hydrated pharmaceutical materials with THz time-domain spectroscopy.
Topics: Ampicillin; Caffeine; Chemistry, Pharmaceutical; Glucose; Hydrogen Bonding; Spectrum Analysis; Theophylline; Water; X-Ray Diffraction | 2007 |
Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals.
Topics: Caffeine; Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Methane; Models, Molecular; Molecular Structure; Nitroparaffins; Stereoisomerism; Tartrates; Theophylline | 2006 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 2007 |
Awareness and use of caffeine by athletes competing at the 2005 Ironman Triathlon World Championships.
Topics: Adult; Awareness; Bicycling; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Humans; Male; Physical Endurance; Prevalence; Running; Surveys and Questionnaires; Swimming; Theophylline | 2006 |
Effect of methylxanthines on production of cellulases by Penicillium echinulatum.
Topics: Aminophylline; beta-Glucosidase; Bioreactors; Caffeine; Cellulases; Culture Media; Glucose; Industrial Microbiology; Penicillium; Theophylline; Xanthines | 2007 |
Pathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Caffeine; Calcium; Cell Line; Cyclic AMP; DNA Fragmentation; Epithelium, Corneal; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphorylation; Rabbits; Theophylline; Ultraviolet Rays; Wortmannin | 2007 |
Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Adenosine A1; Synaptic Transmission; Theophylline | 2007 |
Extraction of radio-labelled xanthine derivatives by artificial receptors: deep insight into the association behaviour.
Topics: Binding Sites; Binding, Competitive; Caffeine; Crystallography, X-Ray; Methylene Chloride; Models, Molecular; Molecular Structure; Radioisotopes; Receptors, Peptide; Solvents; Theophylline; Toluene; Xanthines | 2007 |
Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility.
Topics: Acrylates; Caffeine; Delayed-Action Preparations; Diffusion; Gels; Polyethylene Glycols; Solubility; Theophylline | 2007 |
Guiding bacteria with small molecules and RNA.
Topics: Aptamers, Nucleotide; Bacterial Proteins; Caffeine; Chemotaxis; Escherichia coli; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; RNA, Bacterial; Signal Transduction; Theophylline | 2007 |
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3).
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline | 2007 |
Transdermal and buccal delivery of methylxanthines through human tissue in vitro.
Topics: Administration, Buccal; Administration, Cutaneous; Caffeine; Central Nervous System Stimulants; Excipients; Humans; In Vitro Techniques; Mouth Mucosa; Oleic Acid; Permeability; Skin; Skin Absorption; Solubility; Theobromine; Theophylline; Xanthenes | 2007 |
Death by chocolate: a fatal problem for an inquisitive wild parrot.
Topics: Animals; Animals, Wild; Cacao; Caffeine; Fatal Outcome; Male; Parrots; Theobromine; Theophylline; Xanthines | 2007 |
Caffeine intake and small-for-gestational-age birth: modifying effects of xenobiotic-metabolising genes and smoking.
Topics: Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Risk Factors; Smoking; Theophylline | 2007 |
Involvement of adenosinergic receptors in anxiety related behaviours.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Male; Maze Learning; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline | 2007 |
Development of in-tube solid-phase microextraction coupled to pressure-assisted CEC and its application to the analysis of propranolol enantiomers in human urine.
Topics: Caffeine; Capillary Electrochromatography; Pressure; Propranolol; Solid Phase Microextraction; Theobromine; Theophylline | 2007 |
Engineering high-speed allosteric hammerhead ribozymes.
Topics: Allosteric Regulation; Allosteric Site; Animals; Base Sequence; Caffeine; Cell Line; Clone Cells; Gene Expression Regulation; Genetic Engineering; Humans; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Regulatory Sequences, Ribonucleic Acid; RNA, Catalytic; Schistosoma mansoni; SELEX Aptamer Technique; Sequence Analysis, RNA; Theophylline | 2007 |
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Ethanol; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Male; Prospective Studies; Theobromine; Theophylline; Treatment Outcome | 2008 |
Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.
Topics: Anions; Beverages; Binding Sites; Caffeine; Chlorogenic Acid; Cinnamates; Coffee; Electric Conductivity; Electrophoresis, Capillary; Hydrophobic and Hydrophilic Interactions; Kinetics; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 2007 |
Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Caffeine; Child; Cytochrome P-450 CYP1A2; Dioxins; Environmental Exposure; Environmental Pollutants; Female; Follow-Up Studies; Humans; Lactation; Liver; Male; Maternal-Fetal Exchange; Netherlands; Pregnancy; Theophylline; Thyrotropin; Thyroxine | 2008 |
Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets.
Topics: Alginates; Caffeine; Calcium Compounds; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Gels; Kinetics; Particle Size; Pectins; Pharmaceutical Preparations; Solubility; Surface Properties; Theobromine; Theophylline | 2007 |
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity | 2007 |
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.
Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Genotype; Growth Disorders; Human Growth Hormone; Humans; Injections, Subcutaneous; Male; Mixed Function Oxygenases; Recombinant Proteins; Theophylline; Uric Acid | 2008 |
Inelastic neutron scattering study of methyl groups rotation in some methylxanthines.
Topics: Caffeine; Methylation; Models, Chemical; Models, Molecular; Neutron Diffraction; Rotation; Spectrum Analysis; Theobromine; Theophylline; Thermodynamics; Xanthines | 2007 |
The spectrophotometric determination of the dissociation constants of theophylline, theobromine, and caffeine.
Topics: Caffeine; Humans; Spectrophotometry; Theobromine; Theophylline | 1949 |
Action of caffeine and aminophylline as respiratory stimulants in man.
Topics: Aminophylline; Caffeine; Humans; Male; Respiratory System Agents; Theophylline | 1949 |
Salivary aldehyde dehydrogenase--reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method.
Topics: Adult; Aldehyde Dehydrogenase; Aldehydes; Caffeine; Fluorometry; Glutathione; Humans; Kinetics; Middle Aged; NAD; NADP; Naphthalenes; Oxidation-Reduction; Saliva; Theophylline | 2008 |
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines | 2008 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Prospective Studies; Saliva; Sensitivity and Specificity; Surveys and Questionnaires; Theophylline | 2008 |
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
Topics: Acetaminophen; Antipyrine; Aspirin; Beverages; Biological Products; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Codeine; Cosmetics; Food Analysis; Linear Models; Pharmaceutical Preparations; Salicylic Acid; Theobromine; Theophylline | 2008 |
Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Food Analysis; Plant Preparations; Theobromine; Theophylline; Xanthines | 2008 |
Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?
Topics: Caffeine; Crystallization; Crystallography, X-Ray; Drug Stability; Hydrogen Bonding; Malates; Molecular Structure; Stereoisomerism; Tartrates; Theophylline; Water | 2008 |
Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse.
Topics: Acetaldehyde; Amphetamine; Biological Transport; Caffeine; Cell Line, Tumor; Cell Survival; Choriocarcinoma; Cytochalasin B; Deoxyglucose; Diet; Dronabinol; Ethanol; Flavonoids; Glucose; Humans; Illicit Drugs; Kinetics; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Phenols; Polyphenols; Theophylline; Trophoblasts | 2008 |
In vitro reactivity of urinary bladder smooth muscle in rabbits influenced by xanthine derivatives.
Topics: Acetylcholine; Animals; Caffeine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rabbits; Theophylline; Urinary Bladder | 2008 |
Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
Topics: Animals; Apoptosis; Caffeine; Cell Death; Cell Survival; Cells, Cultured; Dopamine; Embryo, Mammalian; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; Mesencephalon; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Solubility; Theophylline | 2008 |
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.
Topics: Adolescent; Adult; Age Factors; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Phenotype; Risk Factors; Sex Factors; Smoking; Spain; Theophylline; Uric Acid | 2008 |
Surface-imprinted nanostructured layer-by-layer film for molecular recognition of theophylline derivatives.
Topics: Acrylic Resins; Caffeine; Chemistry, Physical; Cross-Linking Reagents; Disulfides; Kinetics; Light; Models, Chemical; Nanoparticles; Nanotechnology; Polymers; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Surface Properties; Theophylline | 2008 |
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.
Topics: Acetaminophen; Analgesics; Anticonvulsants; Bronchodilator Agents; Caffeine; Calibration; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Histamine H2 Antagonists; Humans; Infant, Newborn; Phenytoin; Quality Control; Ranitidine; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline | 2008 |
Vibrational spectra of anhydrous and monohydrated caffeine and theophylline molecules and crystals.
Topics: Caffeine; Computer Simulation; Hydrogen Bonding; Models, Chemical; Spectrophotometry, Infrared; Theophylline; Vibration; Water | 2008 |
New syntheses of caffeine and theophylline.
Topics: Caffeine; Theophylline | 1948 |
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation.
Topics: Biosensing Techniques; Caffeine; Chemistry, Pharmaceutical; Colorimetry; Cross-Linking Reagents; DNA; Dose-Response Relationship, Drug; Drug Design; Gold; Metal Nanoparticles; Molecular Conformation; Nanotechnology; Nucleic Acid Hybridization; Sensitivity and Specificity; Theophylline | 2008 |
Modulation of butyrate transport in Caco-2 cells.
Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetaldehyde; Acids, Acyclic; Aspirin; Biological Transport, Active; Butyrates; Caco-2 Cells; Caffeine; Cell Survival; Dronabinol; Gene Expression; Humans; Hydrogen-Ion Concentration; Indomethacin; Ions; Kinetics; Monocarboxylic Acid Transporters; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Azide; Symporters; Theophylline | 2009 |
Determination of hydrate transition temperature using transformation kinetics obtained by Raman spectroscopy.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Kinetics; Molecular Structure; Molecular Weight; Phase Transition; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; Theophylline; Thermodynamics; Time Factors; Transition Temperature; Water | 2009 |
Fluorescence emission properties of 8-aza analogues of caffeine, theophylline, and related N-alkyl xanthines.
Topics: Aza Compounds; Caffeine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Xanthines | 2009 |
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.
Topics: Animals; Blotting, Western; Caffeine; Cells, Cultured; Connective Tissue Growth Factor; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Hepatocytes; Inhibitory Concentration 50; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Theobromine; Theophylline | 2009 |
Application and analysis of structure-switching aptamers for small molecule quantification.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; Nucleic Acid Conformation; Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Theophylline | 2009 |
Grafting of molecularly imprinted polymers on iniferter-modified carbon nanotube.
Topics: Binding Sites; Biosensing Techniques; Caffeine; Kinetics; Microscopy, Electron, Scanning; Molecular Imprinting; Molecular Structure; Nanotubes, Carbon; Polymers; Theobromine; Theophylline | 2009 |
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analgesics, Opioid; Animals; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Phenethylamines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinidine; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P2; Substance Withdrawal Syndrome; Theobromine; Theophylline | 2009 |
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines | 2009 |
Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.
Topics: Age Factors; Caffeine; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reference Values; Sequence Deletion; Smoking; Theophylline; Turkey | 2009 |
[A comparative study of the effects of Acanthopanacis senticosi injection, theophylline and caffeine on human sperm mobility in vitro].
Topics: Caffeine; Drugs, Chinese Herbal; Eleutherococcus; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline | 2009 |
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
Topics: Adolescent; Adult; Caffeine; Cardiovascular Diseases; Cytochrome P-450 CYP1A2; Enzyme Activation; Humans; Male; Phenanthrenes; Theophylline; Time Factors | 2009 |
Nano- and macro-geometrical structural change of caffeine and theophylline anhydrate tablets during hydration process by using X-ray computed tomography.
Topics: Caffeine; Compressive Strength; Humidity; Kinetics; Nanostructures; Powders; Pressure; Tablets; Theophylline; Time Factors; Tomography, X-Ray Computed; Water; X-Ray Diffraction | 2009 |
Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Caffeine; Central Nervous System Stimulants; Cognition; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Maze Learning; Mice; Mice, Transgenic; Microdialysis; Phosphodiesterase Inhibitors; Plasma; Presenilin-1; Theophylline; Time Factors | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles | 2009 |
Regulation of cerebrospinal fluid production by caffeine consumption.
Topics: Animals; Blotting, Western; Caffeine; Cerebral Ventricles; Cerebrospinal Fluid; Cerebrovascular Circulation; Choroid Plexus; Immunohistochemistry; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium-Potassium-Exchanging ATPase; Theophylline | 2009 |
The interaction of lysozyme with caffeine, theophylline and theobromine in solution.
Topics: Animals; Binding Sites; Caffeine; Chickens; Energy Transfer; Kinetics; Muramidase; Protein Conformation; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Theobromine; Theophylline | 2010 |
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines | 2008 |
Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
Topics: beta-Thalassemia; Caffeine; Case-Control Studies; Child; Confidence Intervals; Cytochrome P-450 CYP1A2; Female; Ferritins; Glutathione; Hemoglobin E; Humans; Lipid Peroxides; Liver; Male; Multivariate Analysis; Oxidative Stress; Sex Factors; Thailand; Theophylline; Transaminases | 2009 |
[Rapid determination of theophylline, theobromine and caffeine in dietary supplements containing guarana by ultra-performance liquid chromatography].
Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dietary Supplements; Mass Spectrometry; Paullinia; Theobromine; Theophylline | 2009 |
Zirconia based monoliths used in hydrophilic-interaction chromatography for original selectivity of xanthines.
Topics: Caffeine; Chromatography, Liquid; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Osmolar Concentration; Silicon Dioxide; Theophylline; Water; Xanthines; Zirconium | 2010 |
Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caffeine; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease, Secondary; Theophylline; Time Factors | 2010 |
Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.
Topics: Animals; Caffeine; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Glucose Transporter Type 4; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Male; Muscle Contraction; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Theophylline; Threonine; Time Factors | 2010 |
The lipotropic activity of caffeine, theobromine and theophylline.
Topics: Caffeine; Lipotropic Agents; Theobromine; Theophylline | 1947 |
Infrared vibrational spectra as a structural probe of gaseous ions formed by caffeine and theophylline.
Topics: Caffeine; Gases; Molecular Probes; Molecular Structure; Spectrophotometry, Infrared; Theophylline | 2010 |
Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
Topics: Acetonitriles; Beverages; Caffeine; Capillary Electrochromatography; Electroosmosis; Food Analysis; Hydrogen-Ion Concentration; Inorganic Chemicals; Linear Models; Microscopy, Electron, Scanning; Organic Chemicals; Phase Transition; Phosphates; Reproducibility of Results; Sensitivity and Specificity; Silicon Dioxide; Sulfonic Acids; Theophylline | 2010 |
Rapid determination of methylxanthines in real samples by high-performance liquid chromatography using the new FastGradient narrow-bore monolithic column.
Topics: Beverages; Caffeine; Carbonated Beverages; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Coffee; Food Analysis; Food Contamination; Limit of Detection; Pharmaceutical Preparations; Reproducibility of Results; Tablets; Tea; Theobromine; Theophylline; Water; Xanthines | 2010 |
Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Caffeine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; In Vitro Techniques; Interneurons; Nerve Net; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Respiratory Insufficiency; Respiratory Physiological Phenomena; Rolipram; Theophylline; Xanthines | 2010 |
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatic Artery; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Portal Vein; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Vascular Resistance; Vasodilation; Vasodilator Agents | 2010 |
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation.
Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theophylline; Uric Acid | 2011 |
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Modafinil; Motor Activity; Narcolepsy; Neuropeptides; Nuclear Proteins; Orexins; Sleep; Theophylline; Transcription Factors | 2010 |
Effect of core size and excipients on the lag time and drug release from a pulsatile drug delivery system.
Topics: Caffeine; Cellulose; Chemistry, Pharmaceutical; Dosage Forms; Drug Carriers; Drug Delivery Systems; Excipients; Hydrophobic and Hydrophilic Interactions; Lactose; Particle Size; Polymers; Solubility; Tablets; Tablets, Enteric-Coated; Theophylline | 2011 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enoxacin; Humans; Male; Norfloxacin; Reproducibility of Results; Sensitivity and Specificity; Theophylline | 2011 |
Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochromes; Drugs, Chinese Herbal; Enzyme Inhibitors; Half-Life; Humans; Injections, Intraperitoneal; Liver; Male; Metabolic Clearance Rate; Microsomes, Liver; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Substrate Specificity; Theophylline | 2010 |
Transmission electron microscopy of pharmaceutical materials.
Topics: Acetaminophen; Caffeine; Crystallization; Microscopy, Electron, Transmission; Oxalic Acid; Pharmaceutical Preparations; Ranitidine; Theophylline | 2010 |
Disposition kinetics of caffeine and paraxanthine in Nile tilapia (Oreochromis niloticus): characterization of the main metabolites.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cichlids; Male; Theophylline; Tissue Distribution; Water Pollutants, Chemical | 2011 |
Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
Topics: Acridine Orange; Antineoplastic Agents; Biophysical Phenomena; Caffeine; Carcinogens; Chlorophyll; Chlorophyllides; Diet; DNA; Humans; Male; Mutagens; Neoplasms; Theobromine; Theophylline; Xanthines | 2010 |
Pharmacokinetics and metabolism of natural methylxanthines in animal and man.
Topics: Animals; Caffeine; Female; Humans; Male; Metabolic Networks and Pathways; Theobromine; Theophylline; Tissue Distribution; Xanthines | 2011 |
Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.
Topics: Amino Acid Sequence; Bacterial Proteins; Caffeine; Carbon; Formaldehyde; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Nitrogen; Pseudomonas putida; Sequence Alignment; Substrate Specificity; Theobromine; Theophylline; Xanthines | 2011 |
Effect of caffeine and theophylline on striated muscle work curves.
Topics: Caffeine; Humans; Muscle, Skeletal; Muscle, Striated; Muscles; Theophylline; Work | 1946 |
Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines.
Topics: Amines; Caffeine; Calorimetry; Carcinogens; Heterocyclic Compounds; Mutagenicity Tests; Pentoxifylline; Salmonella typhimurium; Spectrum Analysis; Theophylline; Vibrio; Xanthines | 2011 |
Ultrasonic quantification using smart hydrogel sensors.
Topics: Biosensing Techniques; Caffeine; Chemistry Techniques, Analytical; Hydrogel, Polyethylene Glycol Dimethacrylate; Molecular Imprinting; Theophylline; Time Factors; Ultrasonics | 2011 |
Inkjet printing of drug substances and use of porous substrates-towards individualized dosing.
Topics: Acetaminophen; Administration, Oral; Caffeine; Chromatography, Liquid; Dosage Forms; Mass Spectrometry; Paper; Pharmaceutical Preparations; Porosity; Precision Medicine; Printing; Solutions; Technology, Pharmaceutical; Theophylline | 2011 |
Caffeine and insulin resistance in pregnancy.
Topics: Birth Weight; Caffeine; Female; Homeostasis; Humans; Infant, Newborn; Insulin Resistance; Male; Pregnancy; Theophylline | 2011 |
Effect of source variation on drug release from HPMC tablets: linear regression modeling for prediction of drug release.
Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Compressive Strength; Drug Compounding; Drug Design; Drug Industry; Excipients; Forecasting; Hypromellose Derivatives; Linear Models; Methylcellulose; Models, Chemical; Molecular Weight; Pharmaceutical Preparations; Solubility; Tablets; Theobromine; Theophylline; Viscosity | 2011 |
Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Caffeine; Coffee; Cognition Disorders; Cytokines; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Humans; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuropsychological Tests; Peptide Fragments; Phosphodiesterase Inhibitors; Presenilin-1; Theophylline; Time Factors | 2011 |
Controlled fabrication of theophylline imprinted polymers on multiwalled carbon nanotubes via atom transfer radical polymerization.
Topics: Adsorption; Caffeine; Microscopy, Electron, Transmission; Molecular Imprinting; Nanotechnology; Nanotubes, Carbon; Polymers; Spectroscopy, Fourier Transform Infrared; Theophylline | 2011 |
Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Induction; Indole Alkaloids; Quinazolines; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Vasodilator Agents | 2011 |
Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Female; Goats; Liver; Oxidation-Reduction; Reference Standards; Theobromine; Theophylline | 2011 |
Clinical and physiological correlates of caffeine and caffeine metabolites in primary insomnia.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Male; Neuropsychological Tests; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Theophylline | 2011 |
Low- and high-frequency Raman investigations on caffeine: polymorphism, disorder and phase transformation.
Topics: Caffeine; Crystallization; Kinetics; Phase Transition; Spectrum Analysis, Raman; Temperature; Theophylline | 2011 |
Combined effects of THC and caffeine on working memory in rats.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Dronabinol; Drug Synergism; Male; Memory, Short-Term; Rats; Rats, Long-Evans; Receptor, Adenosine A1; Theophylline | 2012 |
Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine.
Topics: Animals; Caffeine; Drug Interactions; Eating; Motor Activity; Piperazines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Theophylline | 2011 |
Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers.
Topics: Caffeine; Chemistry; Chromatography; Chromatography, Supercritical Fluid; Hydrogen Bonding; Methanol; Pharmaceutical Preparations; Pressure; Solubility; Solvents; Stereoisomerism; Temperature; Theophylline | 2011 |
Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats.
Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Activation; Enzyme Inhibitors; Ephedra; Glycyrrhiza; Liver; Male; Random Allocation; Rats; Rats, Wistar; Tablets; Theophylline; Time Factors; Water | 2012 |
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Computer Simulation; Cyclosporine; Female; Gastrointestinal Tract; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Obesity, Morbid; Pharmacokinetics; Phenytoin; Regional Blood Flow; Theophylline; Young Adult | 2011 |
Caffeine as an indicator for the quantification of untreated wastewater in karst systems.
Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Environmental Monitoring; Germany; Groundwater; Seasons; Sewage; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Movements; Water Pollutants, Chemical | 2012 |
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Water Pollutants, Chemical | 2011 |
Diffusion of small molecules in a chitosan/water gel determined by proton localized NMR spectroscopy.
Topics: Caffeine; Caprolactam; Chitosan; Diffusion; Gels; Magnetic Resonance Spectroscopy; Protons; Theophylline; Water | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol | 2012 |
A general strategy for performing temperature-programming in high performance liquid chromatography--further improvements in the accuracy of retention time predictions of segmented temperature gradients.
Topics: Aspartame; Caffeine; Chromatography, High Pressure Liquid; Food Additives; Linear Models; Models, Chemical; Reproducibility of Results; Rutin; Temperature; Theobromine; Theophylline | 2012 |
New specific marker of cytochrome P450 1A2 activity.
Topics: Algorithms; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Humans; Models, Theoretical; Phenotype; Theophylline | 2011 |
Development of a chromatographic low pressure flow injection system: application to the analysis of methylxanthines in coffee.
Topics: Beverages; Caffeine; Chromatography, Liquid; Coffee; Flow Injection Analysis; Food Analysis; Limit of Detection; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines | 2012 |
Online coupling of digital microfluidic devices with mass spectrometry detection using an eductor with electrospray ionization.
Topics: Analysis of Variance; Caffeine; Equipment Design; Microfluidic Analytical Techniques; Spectrometry, Mass, Electrospray Ionization; Theophylline | 2012 |
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Stability; Humans; Imidazoles; Linear Models; Liquid-Liquid Extraction; Losartan; Omeprazole; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles; Theophylline | 2012 |
Changes in CYP1A2 activity in humans after 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) administration using caffeine as a probe drug.
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Female; Half-Life; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Sex Factors; Theophylline | 2012 |
Caffeine relaxes smooth muscle through actin depolymerization.
Topics: Actins; Animals; Biopolymers; Caffeine; Cattle; Enzyme Assays; Humans; In Vitro Techniques; Indoles; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Kinase; Permeability; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Polymerization; Potassium Chloride; Theophylline | 2012 |
Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Analysis of Variance; Blotting, Western; Caffeine; Colforsin; Cyclic AMP; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Humans; In Vitro Techniques; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Theophylline; Trophoblasts | 2012 |
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction | 2013 |
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish | 2012 |
Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers.
Topics: Adolescent; Asian People; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Haplotypes; Humans; Male; Polymorphism, Single Nucleotide; Theophylline; Young Adult | 2013 |
High-throughput 96-well solvent mediated sonic blending synthesis and on-plate solid/solution stability characterization of pharmaceutical cocrystals.
Topics: Benzothiazoles; Caffeine; Crystallization; Drug Stability; High-Throughput Screening Assays; Oxalic Acid; Pyrimidines; Solubility; Solvents; Theophylline; X-Ray Diffraction | 2013 |
Spectral analysis of naturally occurring methylxanthines (theophylline, theobromine and caffeine) binding with DNA.
Topics: Caffeine; DNA; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline | 2012 |
Direct coupling of packed column supercritical fluid chromatography to continuous corona discharge ion mobility spectrometry.
Topics: Caffeine; Carbon Dioxide; Chromatography, Supercritical Fluid; Ions; Medroxyprogesterone; Rheology; Spectrum Analysis; Testosterone; Theophylline | 2013 |
Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Humans; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Theophylline | 2013 |
Comparative study of the interactions between ovalbumin and three alkaloids by spectrofluorimetry.
Topics: Binding Sites; Caffeine; Dyphylline; Fluorescence; Hydrogen Bonding; Molecular Structure; Ovalbumin; Protein Binding; Spectrometry, Fluorescence; Theophylline; Thermodynamics | 2013 |
Diurnal variation in CYP1A2 enzyme activity in South Asians and Europeans.
Topics: Adult; Asian People; Caffeine; Circadian Rhythm; Cytochrome P-450 CYP1A2; Female; Humans; Male; Pharmaceutical Preparations; Saliva; Theophylline; White People; Young Adult | 2013 |
Spectroscopic investigations and hydrogen bond interactions of 8-aza analogues of xanthine, theophylline and caffeine: a theoretical study.
Topics: Antineoplastic Agents; Antiviral Agents; Aza Compounds; Caffeine; Gases; Hydrogen Bonding; Kinetics; Models, Chemical; Quantum Theory; Solutions; Spectrum Analysis; Stereoisomerism; Theophylline; Thermodynamics; Water; Xanthines | 2013 |
Caffeine has greater potency and efficacy than theophylline to reverse the motor impairment caused by chronic but not acute interruption of striatal dopaminergic transmission in rats.
Topics: Animals; Caffeine; Catalepsy; Corpus Striatum; Dopaminergic Neurons; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Skills; Oxidopamine; Parkinsonian Disorders; Rats; Theophylline | 2013 |
Guarana powder polysaccharides: characterisation and evaluation of the antioxidant activity of a pectic fraction.
Topics: Antioxidants; Caffeine; Paullinia; Pectins; Plant Extracts; Seeds; Theobromine; Theophylline | 2012 |
Computational design and biosensor applications of small molecule-sensing allosteric ribozymes.
Topics: Allosteric Site; Biosensing Techniques; Caffeine; Genetic Engineering; Nucleic Acid Conformation; RNA, Catalytic; Theophylline | 2013 |
Comparative study of the binding of pepsin to four alkaloids by spectrofluorimetry.
Topics: Absorption; Alkaloids; Aminophylline; Caffeine; Dyphylline; Energy Transfer; Hydrogen-Ion Concentration; Kinetics; Light; Pepsin A; Protein Binding; Protein Conformation; Scattering, Radiation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Theophylline | 2013 |
Morpho-physiological heterogeneity of cells within two rat prostate carcinoma cell lines AT-2 and MAT-LyLu differing in the degree of malignancy observed by cell cloning and the effects of caffeine, theophylline and papaverine upon a proportion of the clo
Topics: Animals; Caffeine; Cell Line, Tumor; Cell Movement; Clone Cells; Connexin 43; Male; Neoplasm Invasiveness; Papaverine; Prostatic Neoplasms; Rats; Snail Family Transcription Factors; Theophylline; Transcription Factors | 2013 |
Simultaneous in vivo phenotyping of CYP enzymes.
Topics: Caffeine; Cytochrome P-450 Enzyme System; Humans; Liquid-Liquid Extraction; Phenotype; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Time Factors | 2013 |
A piezoelectric drop-on-demand generator for accurate samples in capillary electrophoresis.
Topics: Bronchodilator Agents; Caffeine; Electrophoresis, Microchip; Equipment Design; Limit of Detection; Sample Size; Theobromine; Theophylline | 2013 |
Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.
Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Haplorhini; Humans; Hydroxylation; Liver; Metabolic Networks and Pathways; Methylation; Microsomes, Liver; Molecular Docking Simulation; Oxidation-Reduction; Recombinant Proteins; Theophylline | 2013 |
Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Theobromine; Theophylline | 2013 |
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment | 2013 |
Simultaneous determination of caffeine, theophylline and theobromine in food samples by a kinetic spectrophotometric method.
Topics: Beverages; Caffeine; Kinetics; Neural Networks, Computer; Spectrophotometry; Theobromine; Theophylline; Xanthines | 2013 |
A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity.
Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Male; Models, Biological; Theophylline; Xanthines; Young Adult | 2013 |
[Evaluation of pharmacokinetic interaction of aphobazole with CYP1A2 drug-substrate in experiments].
Topics: Administration, Oral; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Benzimidazoles; Biotransformation; Caffeine; Chromatography, Gas; Cytochrome P-450 CYP1A2; Cytochromes; Drug Administration Schedule; Drug Interactions; Male; Morpholines; Rats; Theobromine; Theophylline | 2013 |
UHPLC determination of catechins for the quality control of green tea.
Topics: Caffeine; Calibration; Camellia sinensis; Catechin; Chromatography, High Pressure Liquid; Electrochemistry; Geography; Kinetics; Mass Spectrometry; Micelles; Plant Extracts; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tea; Theobromine; Theophylline | 2014 |
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons.
Topics: Animals; Caffeine; Inhalation; Interneurons; Motor Neurons; Neural Pathways; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Respiratory Center; Seizures; Theophylline; Xanthines | 2013 |
Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: which measure of variability should be used?
Topics: Adult; Area Under Curve; Biomedical Research; Caffeine; Child; Child, Preschool; Female; Humans; Ibuprofen; Infant; Infant, Newborn; Itraconazole; Male; Midazolam; Models, Biological; Pharmacokinetics; Sample Size; Theophylline | 2014 |
Xanthine derivatives quantification in serum by capillary zone electrophoresis.
Topics: Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Reproducibility of Results; Sensitivity and Specificity; Theophylline; Xanthines | 2014 |
Digitally enhanced thin layer chromatography: further development and some applications in isotopic chemistry.
Topics: Anthraquinones; Caffeine; Carotenoids; Chromatography, Thin Layer; Image Processing, Computer-Assisted; Isotope Labeling; Lepidium sativum; Sensitivity and Specificity; Theophylline; Tritium | 2013 |
Caffeine accelerates recovery from general anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous; Animals; Caffeine; Central Nervous System Stimulants; Colforsin; Isoflurane; Neurons; PC12 Cells; Propofol; Rats; Theophylline | 2014 |
An investigation of the causes of cocrystal dissociation at high humidity.
Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Humidity; Pharmaceutical Preparations; Solubility; Theophylline; Water | 2014 |
A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data.
Topics: Adolescent; Adult; Age Factors; Alfentanil; Amides; Caffeine; Child; Child, Preschool; Computer Simulation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Female; Humans; Infant; Infant, Newborn; Liver; Male; Metabolic Clearance Rate; Midazolam; Models, Biological; Ropivacaine; Theophylline | 2014 |
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2].
Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines | 2014 |
Cocrystal dissociation in the presence of water: a general approach for identifying stable cocrystal forms.
Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Humidity; Oxalic Acid; Pharmaceutical Preparations; Theophylline; Thermodynamics; Water | 2014 |
Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit.
Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Caffeine; Fruit; Methylation; Methyltransferases; Molecular Structure; Paullinia; Plant Leaves; Purines; Seeds; Theobromine; Theophylline; Xanthines | 2014 |
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: studies using medium to high doses in animal models.
Topics: Affect; Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Purinergic P1 Receptor Antagonists; Theophylline | 2014 |
Facile fabrication of a novel anisotropic gold nanoparticle-chitosan-ionic liquid/graphene modified electrode for the determination of theophylline and caffeine.
Topics: Caffeine; Chitosan; Electrochemical Techniques; Electrodes; Gold; Graphite; Imidazoles; Ionic Liquids; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Theophylline | 2014 |
Why dried blood spots are an ideal tool for CYP1A2 phenotyping.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Female; Healthy Volunteers; Humans; Male; Middle Aged; Phenotype; Regression Analysis; Theophylline; Young Adult | 2014 |
Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy.
Topics: Caffeine; Carbamazepine; Crystallization; Crystallography; Ethanol; Filtration; Molecular Structure; Pharmaceutical Preparations; Powders; Pyrazoles; Pyridones; Solutions; Solvents; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theophylline; Vibration; Water | 2014 |
CYP1A2 phenotyping in dried blood spots and microvolumes of whole blood and plasma.
Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Humans; Plasma; Reproducibility of Results; Tandem Mass Spectrometry; Theophylline | 2014 |
Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study.
Topics: Adult; Caffeine; Female; Fetal Blood; Humans; Infant, Newborn; Logistic Models; Male; Pilot Projects; Poland; Pregnancy; Theophylline; Young Adult | 2014 |
Potassium-based algorithm allows correction for the hematocrit bias in quantitative analysis of caffeine and its major metabolite in dried blood spots.
Topics: Algorithms; Caffeine; Dried Blood Spot Testing; Hematocrit; Humans; Limit of Detection; Potassium; Theophylline | 2014 |
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors.
Topics: ATP-Binding Cassette Transporters; Caffeine; Carbolines; Cyclic AMP; Cyclic GMP; Dipyridamole; Humans; Imidazoles; Kinetics; Multidrug Resistance-Associated Proteins; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purinones; Sulfones; Tadalafil; Theophylline; Triazines; Vardenafil Dihydrochloride | 2014 |
Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions.
Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Theobromine; Theophylline | 2015 |
Paraxanthine/Caffeine Concentration Ratios in Hair: An Alternative for Plasma-Based Phenotyping of Cytochrome P450 1A2?
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Hair; Humans; Male; Middle Aged; Phenotype; Theophylline; Young Adult | 2015 |
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Logistic Models; Male; Maternal Behavior; Obesity; Pregnancy; Pregnancy Trimester, Second; Prenatal Exposure Delayed Effects; Risk Factors; Theophylline | 2015 |
Adenosine signaling in reserpine-induced depression in rats.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Brain; Caffeine; Depressive Disorder; Dose-Response Relationship, Drug; Flavins; Male; Neuropsychological Tests; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reserpine; Swimming; Theophylline | 2015 |
Equilibrium water and solute uptake in silicone hydrogels.
Topics: Caffeine; Hydrogels; Hydrophobic and Hydrophilic Interactions; Silicones; Solvents; Theophylline; Water | 2015 |
Genoprotective and hepatoprotective effects of Guarana (Paullinia cupana Mart. var. sorbilis) on CCl4-induced liver damage in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Carbon Tetrachloride; DNA Damage; Dose-Response Relationship, Drug; Hepatocytes; Liver Diseases; Male; Rats; Rats, Wistar; Silymarin; Theobromine; Theophylline | 2016 |
Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine.
Topics: Antineoplastic Agents; Biological Products; Caffeine; Cell Line, Tumor; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Hydrophobic and Hydrophilic Interactions; Methane; Molecular Conformation; Silver; Theobromine; Theophylline; Xanthine | 2015 |
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake.
Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult | 2015 |
Effects of caffeine and its metabolite paraxanthine on intracranial self-stimulation in male rats.
Topics: Animals; Caffeine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Self Stimulation; Theophylline | 2015 |
Quantitative on-line concentration for capillary electrophoresis with inkjet sample introduction technique.
Topics: Caffeine; Electrophoresis, Capillary; Limit of Detection; Theobromine; Theophylline | 2015 |
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline | 2015 |
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Volunteers; Hematocrit; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline | 2015 |
Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks.
Topics: Animals; Animals, Newborn; CA3 Region, Hippocampal; Caffeine; Calcium; Nerve Net; Pyramidal Cells; Rats; Receptors, GABA-A; Receptors, Glycine; Seizures; Theophylline; Xanthines | 2015 |
Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population.
Topics: Adolescent; Adult; Age Factors; Algorithms; Biomarkers; Biotransformation; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Food, Preserved; Humans; Male; Nigeria; Sex Characteristics; Theophylline; Uric Acid; Young Adult | 2015 |
Simultaneous multiplexed quantification of caffeine and its major metabolites theobromine and paraxanthine using surface-enhanced Raman scattering.
Topics: Caffeine; Humans; Limit of Detection; Machine Learning; Neural Networks, Computer; Spectrum Analysis, Raman; Surface Properties; Theobromine; Theophylline | 2015 |
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
Topics: Adult; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Risk Assessment; Theophylline; Young Adult | 2015 |
Response Surface Optimization for Decaffeination and Theophylline Production by Fusarium solani.
Topics: Caffeine; Chromatography, Liquid; Fusarium; Mass Spectrometry; Microscopy, Electron, Scanning; Theophylline | 2016 |
An optimized and validated SPE-LC-MS/MS method for the determination of caffeine and paraxanthine in hair.
Topics: Adult; Analytic Sample Preparation Methods; Caffeine; Chromatography, Liquid; Female; Hair; Humans; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Young Adult | 2015 |
Hypercholesterolemia and Ecto-enzymes of Purinergic System: Effects of Paullinia cupana.
Topics: Adenosine Deaminase; Animals; Caffeine; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Hypercholesterolemia; Lymphocytes; Male; Paullinia; Plant Preparations; Rats; Rats, Wistar; Theobromine; Theophylline | 2016 |
Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age.
Topics: Adult; Caffeine; Child; Child Behavior; Child, Preschool; Coffee; Cognition; Female; Follow-Up Studies; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk Factors; Theophylline; Young Adult | 2015 |
Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy.
Topics: Caffeic Acids; Caffeine; Catechin; Chlorogenic Acid; Coffee; Spectroscopy, Near-Infrared; Theobromine; Theophylline; Waste Products | 2016 |
Degradation of exogenous caffeine by Populus alba and its effects on endogenous caffeine metabolism.
Topics: Biodegradation, Environmental; Caffeine; Chromatography, High Pressure Liquid; Hydroponics; Plant Leaves; Plant Roots; Plant Stems; Populus; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Pollutants, Chemical | 2016 |
Correction.
Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Theobromine; Theophylline | 2016 |
Stepwise injection potentiometric determination of caffeine in saliva using single-drop microextraction combined with solvent exchange.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Liquid Phase Microextraction; Potentiometry; Saliva; Theobromine; Theophylline | 2016 |
Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
Topics: Caffeine; Cytokines; Gene Expression Regulation; Gene Silencing; Humans; Immunosuppressive Agents; Low Density Lipoprotein Receptor-Related Protein-1; Methotrexate; Mitogens; RNA, Small Interfering; T-Lymphocytes; Theophylline; Thrombospondin 1 | 2016 |
Application of a Physiologically Based Pharmacokinetic Model to Study Theophylline Metabolism and Its Interactions With Ciprofloxacin and Caffeine.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Bronchodilator Agents; Caffeine; Ciprofloxacin; Computer Simulation; Dose-Response Relationship, Drug; Drug Dosage Calculations; Drug Interactions; Female; Humans; Male; Middle Aged; Models, Biological; Precision Medicine; Sex Factors; Theophylline | 2016 |
[Coffee lowers in a study blood pressure].
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Female; Humans; Male; Theobromine; Theophylline | 2015 |
Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor.
Topics: Caffeine; Carbon; Dielectric Spectroscopy; Electrochemical Techniques; Electrodes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Microscopy, Atomic Force; Molecular Imprinting; Polymers; Theobromine; Theophylline; Tin Compounds | 2016 |
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study.
Topics: Adult; Asian People; Caffeine; Coffee; Female; Humans; Menstrual Cycle; Ovulation; Ovulation Inhibition; Racial Groups; Risk Factors; Testosterone; Theophylline; Young Adult | 2016 |
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.
Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline | 2016 |
Determination of illicit drugs in aqueous environmental samples by online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry.
Topics: Caffeine; China; Chromatography, Liquid; Cotinine; Environmental Monitoring; Illicit Drugs; Pseudoephedrine; Reproducibility of Results; Rivers; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Wastewater; Water Pollutants, Chemical | 2016 |
Control of methylxanthines in the competition horse: pharmacokinetic/pharmacodynamic studies on caffeine, theobromine and theophylline for the assessment of irrelevant concentrations.
Topics: Animals; Caffeine; Chromatography, Liquid; Horses; Theobromine; Theophylline; Xanthines | 2017 |
Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.
Topics: Antigens, CD; Basic Helix-Loop-Helix Transcription Factors; Caffeine; CD83 Antigen; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Genome-Wide Association Study; Humans; Immunoglobulins; Male; Membrane Glycoproteins; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon; Theobromine; Theophylline; White People | 2016 |
Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain.
Topics: Acetylcholinesterase; Animals; Blood Glucose; Brain; Caffeine; Cholesterol; Hyperlipidemias; Male; Maze Learning; Paullinia; Plant Extracts; Poloxamer; Rats; Rats, Wistar; Recognition, Psychology; Statistics, Nonparametric; Surface-Active Agents; Theobromine; Theophylline | 2017 |
Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies.
Topics: Aminosalicylic Acid; Antitubercular Agents; Caffeine; Crystallization; Crystallography, X-Ray; Drug Stability; Isoniazid; Models, Molecular; Niacinamide; Powder Diffraction; Pyrazinamide; Solubility; Theophylline; X-Ray Diffraction | 2017 |
Time domain NMR as a new process monitoring method for characterization of pharmaceutical hydrates.
Topics: Caffeine; Chemistry, Pharmaceutical; Magnetic Resonance Spectroscopy; Spectrum Analysis, Raman; Theophylline; Water | 2017 |
Sperm motility activation in the critically endangered booroolong frog: the effect of medium osmolality and phosphodiesterase inhibitors.
Topics: Animals; Anura; Caffeine; Fertilization in Vitro; Male; Osmolar Concentration; Pentoxifylline; Phosphodiesterase Inhibitors; Semen Analysis; Sperm Motility; Spermatozoa; Theophylline | 2017 |
Structures of Human A
Topics: Binding Sites; Caffeine; HEK293 Cells; Humans; Molecular Docking Simulation; Protein Binding; Receptor, Adenosine A1; Receptor, Adenosine A2A; Substrate Specificity; Theophylline | 2017 |
Saturated phosphatidylcholine as matrix former for oral extended release dosage forms.
Topics: Administration, Oral; Caffeine; Chemistry, Pharmaceutical; Diffusion; Drug Delivery Systems; Drug Liberation; Excipients; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Osmolar Concentration; Particle Size; Phosphatidylcholines; Porosity; Solubility; Tablets; Theophylline | 2017 |
Caffeine and paraxanthine in aquatic systems: Global exposure distributions and probabilistic risk assessment.
Topics: Animals; Aquatic Organisms; Caffeine; Chlorophyta; Daphnia; Fishes; Humans; Risk Assessment; Theophylline; Water Movements; Water Pollutants, Chemical | 2018 |
Mechanistic Insight into Caffeine-Oxalic Cocrystal Dissociation in Formulations: Role of Excipients.
Topics: Caffeine; Crystallization; Drug Compounding; Drug Stability; Excipients; Theophylline; X-Ray Diffraction | 2017 |
Nitrogen-doped carbon nanotubes decorated poly (L-Cysteine) as a novel, ultrasensitive electrochemical sensor for simultaneous determination of theophylline and caffeine.
Topics: Caffeine; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Limit of Detection; Models, Molecular; Molecular Conformation; Nanotubes, Carbon; Nitrogen; Peptides; Theophylline; Time Factors | 2018 |
Chemical profiling of guarana seeds (Paullinia cupana) from different geographical origins using UPLC-QTOF-MS combined with chemometrics.
Topics: Biflavonoids; Brazil; Caffeine; Catechin; Chromatography, High Pressure Liquid; Mass Spectrometry; Paullinia; Phenols; Proanthocyanidins; Seeds; Theobromine; Theophylline | 2017 |
Determination of caffeine, theobromine and theophylline in Mate beer and Mate soft drinks by high-performance thin-layer chromatography.
Topics: Beer; Caffeine; Carbonated Beverages; Chromatography, Thin Layer; Food Analysis; Theobromine; Theophylline | 2018 |
Poly(para-phenyleneethynylene)-Sensor Arrays Discriminate 22 Different Teas.
Topics: Alkynes; Biosensing Techniques; Caffeine; Camellia sinensis; Ethers; Plant Leaves; Tea; Theobromine; Theophylline | 2018 |
An aptamer nanopore-enabled microsensor for detection of theophylline.
Topics: Animals; Aptamers, Nucleotide; Biosensing Techniques; Bronchodilator Agents; Caffeine; Cattle; Equipment Design; Limit of Detection; Nanopores; Plant Extracts; Theobromine; Theophylline; Vasodilator Agents | 2018 |
Application of HRAM screening and LC-MS/MS confirmation of active pharmaceutical ingredient in "natural" herbal supplements.
Topics: Anti-Obesity Agents; Appetite Depressants; Caffeine; Central Nervous System Stimulants; Chromatography, Liquid; Cyclobutanes; Dietary Supplements; Drug Contamination; Humans; Liquid-Liquid Extraction; Mass Spectrometry; Theophylline | 2018 |
Simultaneous determination of theophylline and caffeine on novel [Tetra-(5-chloroquinolin-8-yloxy) phthalocyanato] manganese(III)-Carbon nanotubes composite electrode.
Topics: Caffeine; Cola; Coordination Complexes; Electrochemical Techniques; Electrodes; Manganese; Molecular Structure; Nanotubes, Carbon; Nitriles; Particle Size; Quinolines; Surface Properties; Tea; Theophylline | 2018 |
A new insight into the oxidative mechanism of caffeine and related methylxanthines in aprotic medium: May caffeine be really considered as an antioxidant?
Topics: Antioxidants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Solvents; Theobromine; Theophylline | 2018 |
Biodegradation of caffeine by whole cells of tea-derived fungi Aspergillus sydowii, Aspergillus niger and optimization for caffeine degradation.
Topics: Aspergillus; Aspergillus niger; Biodegradation, Environmental; Caffeine; Fermentation; Substrate Specificity; Tea; Theophylline; Xanthines | 2018 |
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium
Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines | 2018 |
Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Middle Aged; Parkinson Disease; Pilot Projects; Theophylline | 2018 |
Evaluation of the Capitainer-B Microfluidic Device as a New Hematocrit-Independent Alternative for Dried Blood Spot Collection.
Topics: Caffeine; Calibration; Chromatography, Liquid; Dried Blood Spot Testing; Female; Hematocrit; Humans; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques; Tandem Mass Spectrometry; Theophylline | 2018 |
Guarana (Paullinia cupana Mart.) alters gut microbiota and modulates redox status, partially via caffeine in Wistar rats.
Topics: Animals; Antioxidants; Caffeine; Dysbiosis; Gastrointestinal Microbiome; Male; Oxidation-Reduction; Oxidative Stress; Paullinia; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Seeds; Theobromine; Theophylline | 2018 |
Theophylline and Caffeine as Alternatives During an Aminophylline Shortage.
Topics: Aminophylline; Caffeine; Coronary Disease; Drug Utilization; Exercise Test; Female; Humans; Male; Theophylline; Vasodilator Agents | 2019 |
Effect of potassium chloride on the solvation behavior of caffeine, theophylline and theobromine: Volumetric, viscometric, calorimetry and spectroscopic approach.
Topics: Caffeine; Calorimetry; Magnetic Resonance Spectroscopy; Potassium Chloride; Spectrophotometry; Temperature; Theobromine; Theophylline; Thermodynamics; Viscosity; Water | 2018 |
Effect of Formulation on the Binding Efficiency and Selectivity of Precipitation Molecularly Imprinted Polymers.
Topics: Caffeine; Chemical Precipitation; Cross-Linking Reagents; Drug Compounding; Molecular Imprinting; Polymerization; Polymers; Theophylline | 2018 |
A rapid method for the assay of methylxanthines alkaloids: Theobromine, theophylline and caffeine, in cocoa products and drugs by paper spray tandem mass spectrometry.
Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Food Analysis; Limit of Detection; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Theobromine; Theophylline | 2019 |
Lamotrigine: Design and synthesis of new multicomponent solid forms.
Topics: Caffeine; Calorimetry, Differential Scanning; Crystallization; Crystallography, X-Ray; Lamotrigine; Powder Diffraction; Solubility; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Theophylline; Thermodynamics; X-Ray Diffraction | 2019 |
Prediction of self-assembly of adenosine analogues in solution: a computational approach validated by isothermal titration calorimetry.
Topics: Adenosine; Caffeine; Calorimetry; Dimerization; Models, Molecular; Molecular Structure; Solvents; Structure-Activity Relationship; Surface Properties; Theophylline; Thermodynamics; Water | 2019 |
Reliability of the Hansen solubility parameters as co-crystal formation prediction tool.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Niacinamide; Piroxicam; Solubility; Theophylline | 2019 |
Effects of hydroalcoholic and enzyme-assisted extraction processes on the recovery of catechins and methylxanthines from crude and waste seeds of guarana (Paullinia cupana).
Topics: Antioxidants; Caffeine; Catechin; Paullinia; Phenol; Plant Extracts; Seeds; Theobromine; Theophylline; Xanthines | 2019 |
Lipotoxicity-associated inflammation is prevented by guarana (
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperlipidemias; Inflammation; Lymphocytes; Male; Rats; Rats, Wistar; Simvastatin; Theobromine; Theophylline | 2021 |
Production and characterization of solid lipid microparticles loaded with guaraná (Paullinia cupana) seed extract.
Topics: alpha-Amylases; alpha-Glucosidases; Anti-Obesity Agents; Caffeine; Catechin; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Freeze Drying; Fruit; Lipase; Particle Size; Paullinia; Phenols; Plant Extracts; Seeds; Theobromine; Theophylline | 2019 |
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
Topics: Caffeine; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theobromine; Theophylline | 2019 |
Challenging the international residue limit concept for feed contaminants in equine doping analytics.
Topics: Animals; Caffeine; Doping in Sports; Horses; Theophylline | 2019 |
A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries.
Topics: Adult; Aged; Alkaloids; Biomarkers; Caffeine; Coffee; Europe; Female; Humans; Male; Metabolomics; Middle Aged; Prospective Studies; Theophylline | 2019 |
Evaluation of the Performance and Hematocrit Independence of the HemaPEN as a Volumetric Dried Blood Spot Collection Device.
Topics: Caffeine; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Female; Humans; Tandem Mass Spectrometry; Theophylline | 2019 |
Protective effect of guarana-loaded liposomes on hemolytic activity.
Topics: Animals; Antioxidants; Caffeine; Drug Compounding; Hemolysis; Liposomes; Particle Size; Protective Agents; Rats; Theobromine; Theophylline | 2020 |
Production of theophylline via aerobic fermentation of pu-erh tea using tea-derived fungi.
Topics: Aerobiosis; Caffeine; Fermentation; Fungi; Plant Leaves; Secondary Metabolism; Tea; Temperature; Theophylline | 2019 |
Solvent and temperature effect of accelerated solvent extraction (ASE) coupled with ultra-high-pressure liquid chromatography (UHPLC-PDA) for the determination of methyl xanthines in commercial tea and coffee.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Sensitivity and Specificity; Solvents; Tea; Temperature; Theobromine; Theophylline; Xanthines | 2020 |
Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile.
Topics: alpha-Glucosidases; Brazil; Caffeine; Diabetes Mellitus, Type 2; Dietary Supplements; Glycoside Hydrolase Inhibitors; Humans; Medicine, Traditional; Paullinia; Phytochemicals; Plant Extracts; Polyphenols; Proanthocyanidins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Theobromine; Theophylline | 2020 |
In vivo solid-phase microextraction swab sampling of environmental pollutants and drugs in human body for nano-electrospray ionization mass spectrometry analysis.
Topics: Caffeine; Environmental Pollutants; Human Body; Humans; Imidazoles; Mouth; Nanotechnology; Nicotine; Skin; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization; Theobromine; Theophylline | 2020 |
Exploring hand-portable nano-liquid chromatography for in place water analysis: Determination of trimethylxanthines as a use case.
Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Limit of Detection; Solid Phase Microextraction; Theophylline; Water Pollutants, Chemical | 2020 |
Chemical implications and time reduction of on-farm cocoa fermentation by Saccharomyces cerevisiae and Pichia kudriavzevii.
Topics: Amines; Cacao; Caffeine; Catechin; Chocolate; Farms; Fermentation; Food Microbiology; Hydrogen-Ion Concentration; Phenols; Pichia; Saccharomyces cerevisiae; Temperature; Theobromine; Theophylline; Time Factors | 2021 |
Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study.
Topics: Adult; Aged; Caffeine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nutrition Surveys; Theobromine; Theophylline; Urination | 2020 |
Detection of caffeine intake by means of EC-SERS spectroscopy of human saliva.
Topics: Caffeine; Humans; Saliva; Spectrum Analysis; Theophylline | 2021 |
Caffeine inhibits Notum activity by binding at the catalytic pocket.
Topics: Caffeine; Catalytic Domain; Dose-Response Relationship, Drug; Esterases; HEK293 Cells; Humans; Protein Binding; Protein Structure, Tertiary; Theophylline | 2020 |
Simultaneous determination of theobromine, theophylline, and caffeine using a modified electrode with petal-like MnO
Topics: Caffeine; Electrodes; Manganese Compounds; Nanostructures; Oxides; Theobromine; Theophylline | 2021 |
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans; Neuroblastoma; Pentoxifylline; Principal Component Analysis; Theobromine; Theophylline; Transcription, Genetic; Xanthines | 2020 |
Electrochemical sensing platform based on covalent organic framework materials and gold nanoparticles for high sensitivity determination of theophylline and caffeine.
Topics: Acetaminophen; Caffeine; Capsules; Drug Contamination; Electrochemical Techniques; Electrodes; Gold; Limit of Detection; Metal Nanoparticles; Metal-Organic Frameworks; Reproducibility of Results; Tea; Theophylline | 2021 |
Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.
Topics: Adult; Anthropometry; Biomarkers; Birth Weight; Caffeine; Female; Fetal Development; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Pregnancy; Retrospective Studies; Theophylline | 2021 |
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Topics: Animals; Caffeine; Cosmetics; Eating; Humans; Risk Assessment; Theobromine; Theophylline; Toxicity Tests; Xanthines | 2021 |
Methylxanthines in COPD: yes to caffeine, no to theophylline.
Topics: Caffeine; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline; Xanthines | 2021 |
The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS.
Topics: Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Theophylline | 2021 |
[Determination of Caffeine, Theobromine, and Theophylline in Chocolate Using LC-MS].
Topics: Caffeine; Chocolate; Chromatography, Liquid; Reproducibility of Results; Tandem Mass Spectrometry; Theobromine; Theophylline | 2021 |
Complexation of caffeine and theophylline with epigallocatechin gallate in aqueous solution: Nuclear magnetic resonance, molecular docking and thermodynamics studies.
Topics: Caffeine; Catechin; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Theophylline; Thermodynamics | 2021 |
Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies.
Topics: Adult; Belgium; Caffeine; Cholesterol; Cholesterol, HDL; Chromatography, High Pressure Liquid; Female; Humans; Lipids; Male; Middle Aged; Switzerland; Tandem Mass Spectrometry; Theobromine; Theophylline; Triglycerides; Xanthines | 2021 |
Dual genetic selection of the theophylline riboswitch with altered aptamer specificity for caffeine.
Topics: beta-Galactosidase; Caffeine; Chloramphenicol; Drug Resistance; Escherichia coli; Gene Expression Regulation; Green Fluorescent Proteins; Microbial Sensitivity Tests; Oligonucleotides; Plasmids; Recombinant Fusion Proteins; Riboswitch; Selection, Genetic; Theophylline | 2021 |
Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Theobromine; Theophylline; Uric Acid | 2021 |
Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults.
Topics: Adult; Asthma; Bronchodilator Agents; Caffeine; Coffee; Cross-Sectional Studies; Humans; Lung; Nutrition Surveys; Theobromine; Theophylline | 2022 |
Finger sweat analysis enables short interval metabolic biomonitoring in humans.
Topics: Adult; Biological Monitoring; Biotransformation; Caffeine; Chlorogenic Acid; Chromatography, Liquid; Coffee; Female; Fingers; Humans; Male; Metabolomics; Middle Aged; Principal Component Analysis; Sweat; Tandem Mass Spectrometry; Theobromine; Theophylline | 2021 |
Maternal caffeine intake and DNA methylation in newborn cord blood.
Topics: Adult; Caffeine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Middle Aged; Pregnancy; Theobromine; Theophylline | 2022 |
Caffeine and Paraxanthine as Tracers of Anthropogenic Wastewater in Coastal Lagoons in Yucatan, Mexico.
Topics: Caffeine; Environmental Monitoring; Groundwater; Mexico; Theophylline; Wastewater; Water Pollutants, Chemical | 2022 |
Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues.
Topics: Beverages; Caffeine; Calorimetry; Humans; Oligonucleotides; Theobromine; Theophylline | 2022 |
The analysis of methylxanthine fractions obtained from Camellia sinensis cultivated in Turkey and effects on the in vitro inhibition of CYP2D6 enzyme.
Topics: Caffeine; Camellia sinensis; Cytochrome P-450 CYP2D6; Tea; Theobromine; Theophylline; Turkey | 2023 |
Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuroblastoma; Neurodegenerative Diseases; Pentoxifylline; Theobromine; Theophylline; Triglycerides; Xanthines | 2022 |
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Humans; Melatonin; Theophylline | 2022 |
To what extent do bond length and angle govern the
Topics: Caffeine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Theophylline | 2022 |
Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model.
Topics: Animals; Caffeine; Dogs; Harmine; Male; Metabolic Diseases; Metabolome; Obesity; Theophylline | 2022 |
Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk.
Topics: Caffeine; Chromatography, Liquid; Female; Humans; Milk, Human; Tandem Mass Spectrometry; Theobromine; Theophylline | 2022 |
Simultaneous quantification of caffeine and its main metabolites by gas chromatography mass spectrometry in horse urine.
Topics: Animals; Caffeine; Gas Chromatography-Mass Spectrometry; Horses; Solid Phase Extraction; Theobromine; Theophylline | 2022 |
Therapeutic drug monitoring of caffeine and its primary metabolites in plasma using LC-ESI-MS/MS for apnea of prematurity treatment: Evaluation of ultrapure water as a surrogate matrix.
Topics: Animals; Apnea; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Infant, Premature; Rats; Tandem Mass Spectrometry; Theobromine; Theophylline; Water | 2022 |
Interactions between Caffeine, Theophylline and Derivatives with Gold Nanoparticles and Implications for Aptamer-Based Label-Free Colorimetric Detection.
Topics: Caffeine; Colorimetry; Gold; Metal Nanoparticles; Theophylline; Xanthines | 2022 |
A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis.
Topics: Animals; Caffeine; Cysteine; Glutathione; HEK293 Cells; Humans; Hydrogen Peroxide; Mice; Neuroblastoma; Theophylline; Uric Acid | 2023 |
Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cognition; Nutrition Surveys; Theophylline | 2023 |
Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Caffeine; Claudin-2; Doxorubicin; Humans; Lung Neoplasms; NF-E2-Related Factor 2; Theophylline | 2022 |
Association of urinary caffeine and caffeine metabolites with bone mineral density in children and adolescents.
Topics: Adolescent; Adult; Bone Density; Caffeine; Child; Coffee; Cross-Sectional Studies; Female; Humans; Nutrition Surveys; Theophylline; Young Adult | 2022 |
Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients.
Topics: Bronchodilator Agents; Caffeine; Child, Preschool; Diuretics; Dyskinesias; Humans; Phosphodiesterase Inhibitors; Psychomotor Agitation; Theophylline; Vasodilator Agents | 2023 |
Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.
Topics: Analgesics, Opioid; Animals; Caffeine; Fentanyl; Male; Mice; Naloxone; Narcotic Antagonists; Oxycodone; Respiratory Insufficiency; Theophylline | 2023 |
Cross-Binding of Four Adenosine/ATP Aptamers to Caffeine, Theophylline, and Other Methylxanthines.
Topics: Adenosine; Adenosine Triphosphate; Aptamers, Nucleotide; Caffeine; Theophylline | 2023 |
Cross-Binding of Adenosine by Aptamers Selected Using Theophylline.
Topics: Adenosine; Aptamers, Nucleotide; Caffeine; Nucleotide Motifs; Theophylline | 2023 |
Electrochemical Sensing Platform Based on Carbon Dots for the Simultaneous Determination of Theophylline and Caffeine in Tea.
Topics: Caffeine; Carbon; Chitosan; Reproducibility of Results; Tea; Theophylline | 2023 |
Association between urine caffeine metabolites and bone mineral density: A population-based study.
Topics: Adult; Bone Density; Caffeine; Cross-Sectional Studies; Humans; Nutrition Surveys; Theophylline | 2023 |