caffeine and theophylline

caffeine has been researched along with theophylline in 1685 studies

Research

Studies (1,685)

TimeframeStudies, this research(%)All Research%
pre-1990835 (49.55)18.7374
1990's289 (17.15)18.2507
2000's258 (15.31)29.6817
2010's242 (14.36)24.3611
2020's61 (3.62)2.80

Authors

AuthorsStudies
Ishii, A; Karasawa, A; Kawakita, T; Kubo, K; Mizumoto, H; Nonaka, H; Shimada, J; Suzuki, F1
Ishii, A; Nonaka, H; Shimada, J; Suzuki, F1
Ichikawa, S; Ishii, A; Nonaka, H; Shimada, J; Suzuki, F1
Jacobson, KA; van Galen, PJ; Williams, M1
Ishii, A; Karasawa, A; Kubo, K; Mizumoto, H; Nonaka, H; Ohno, T; Shimada, J; Suzuki, F1
Bridson, PK; Daly, JW; Hide, I1
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D1
Bruns, RF; Christ, WJ; Ibay, AC; Schneller, SW1
Butts-Lamb, P; Daly, JW; Padgett, W; Shamim, MT; Waters, J1
Daly, JW; Padgett, WL; Shamim, MT1
Daly, JW; Glennon, RA; Padgett, W; Tejani-Butt, SM1
Daly, JW1
Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Martini, C; Messini, L; Senatore, G1
Grahner, B; Lanzner, W; Müller, CE; Winiwarter, S1
Fuse, E; Ichikawa, S; Ishii, A; Kobayashi, H; Nakamura, J; Nonaka, H; Shimada, J; Shiozaki, S; Suzuki, F1
Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Kiriasis, L; Manning, M; Müller, C; Neumeyer, JL; Pfleiderer, W; Shi, D1
Frobenius, W; Geis, U; Hipp, J; Müller, CE; Pawłowski, M; Sandoval-Ramírez, J; Schobert, U; Suzuki, F1
Eder, C; Frobenius, W; Herderich, M; Müller, CE; Proksch, P; Schupp, P; Steube, K; van Soest, RW; Wray, V1
Brufani, M; Cavallaro, RA; Filocamo, L; Galione, A; Galuppi, A; Genazzani, AA1
Coassolo, P; Lavé, T; Schneider, G1
IJzerman, AP; Ingkaninan, K; Verpoorte, R1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE1
Daly, JW; Diekmann, M; Jacobson, KA; Müller, CE; Padgett, WL; Qurishi, R; Thorand, M1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Borea, PA; Dalpiaz, A; Gilli, G; Gilli, P; Scatturin, A; Varani, K1
Andersen, OA; Demartino, JA; Rao, FV; van Aalten, DM; Vora, KA1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R1
Gwizdek-Wiśniewska, A; Piosik, J; Ulanowska, K; Wegrzyn, G1
Andricopulo, AD; Moda, TL; Montanari, CA1
Bertarelli, DC; Diekmann, M; Hayallah, AM; Iqbal, J; Müller, CE; Preiss, B; Rüsing, D; Verspohl, EJ1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Bearne, SL; Lunn, FA; Roy, AC1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
El-Tayeb, A; Inamdar, GS; Li, W; Müller, CE; Scheiff, AB; Sudarsanam, V; Vasu, KK; Yerande, SG1
Cheng, F; Liu, G; Tang, Y; Xu, Z1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Copits, B; Frausto, S; Gill, MB; Noguchi, K; Sakai, R; Sakurada, T; Shimamoto, K; Swanson, GT1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Akamatsu, M1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Andrews, SP; Congreve, M; Errey, JC; Marshall, FH; Mason, JS; Robertson, N; Tehan, B; Weir, M; Zhukov, A1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L1
Gołuński, G; Iermak, I; Piosik, J; Rychłowski, M; Woziwodzka, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Akkari, R; Borrmann, T; Brunschweiger, A; Drabczyńska, A; Hockemeyer, J; Kieć-Kononowicz, K; Koch, P; Köse, M; Küppers, P; Müller, CE; Radjainia, H; Schlenk, M1
de Lera Ruiz, M; Lim, YH; Zheng, J1
Al-Nadaf, AH; Al-Sha'er, MA; Khanfar, MA; Taha, MO1
Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G1
Hurley, TD; Morgan, CA1
Chan, KL; Lee, CY; Liew, KF1
Azuaje, J; Carbajales, C; Crespo, A; El Maatougui, A; Escalante, L; García-Mera, X; González-Gómez, M; Gutiérrez-de-Terán, H; Miguez, G; Sotelo, E1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G1
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y1
Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X1
Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L1
Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L1
Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L2
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X1
Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y1
An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T1
Doroż-Płonka, A; Drabczyńska, A; Handzlik, J; Hinz, S; Karcz, T; Kieć-Kononowicz, K; Latacz, G; Müller, CE; Schabikowski, J; Stanuch, K; Szymańska, E; Załuski, M1
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z1
Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P1
Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G1
Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C1
Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P1
Cheng, M; Guo, J; Jiang, N; Li, Q; Liang, N; Liu, J; Nong, X; Pang, C; Qin, Y; Tang, C; Tang, W; Xie, SS; Zhang, Z1
Cheng, M; Fang, Y; Guo, J; Jin, Y; Liu, J; Wan, Y; Wang, R; Xie, SS; Zhang, Z; Zhou, W1
Atkinson, BN; Bayle, ED; Fish, PV; Steadman, D; Svensson, F; Vincent, JP; Whiting, P; Willis, NJ; Woodward, HL1
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A1
Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G1
Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW1
Berizzi, A; Bird, L; Culurgioni, S; Navratilova, IH; Olsen, RHJ; Rawlins, PB; Robinson, S; Shepherd, C; Thompson, LEJ; Varzandeh, S1
Frantsuzova, SB2
Helle, KB; Storesund, A1
Arold, R; Chilla, R1
Kostopoulos, GK; Phillis, JW1
Morishima, I2
Chatterjee, SK; Kim, U1
Amelar, RD; Dubin, L; Schoenfeld, C1
Cohn, M; Cohn, ML; Kraynack, BJ; Taylor, FH1
Berry, MS; Pentreath, VW1
Filburn, CR; Karn, J; Wyatt, GR1
Collins, C; Richards, PT; Starmer, GA1
Johno, I; Kitazawa, S; Minouchi, T; Okada, J1
Connett, RJ1
Sacks, LE; Thompson, PA2
Boross, M; Holló, I1
Barbara, L; Borghi, E; Casadio, R; Corinaldesi, R; Paparo, GF; Stanghellini, V; Tonon, R1
Kimura, T; Muranishi, S; Nakamura, J; Sezaki, H; Takamura, R1
Eiceman, GA; Otto, JL; Walton, HF1
Chan, YH; Curtis-Prior, PB; Gibbons, JR1
Aranda, JV; Baltassat, P; Bethenod, M; Bory, C; Frederich, A; Porthault, M2
Boutroy, MJ; Monin, P; Royer, RJ; Royer-Morrot, MJ; Vert, P2
Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A1
Goz, B; Wharton, W3
Mizutani, A; Sugimura, K1
Garcia, L; Rogers, BJ1
Lehnert, S1
Reddy, EP; Sarma, PS; Schulz, RA; Srinivasan, A1
Edstrom, JP; Kirkpatrick, JR; Kostopoulos, GK; Phillis, JW1
Singh, M1
Mircevová, L; Simmonová, A; Viktora, L1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S1
Breuiller, M; Cedard, L; Ferre, F2
Bayless, TM; Brady, PG1
Collier, HO; Francis, DL; Roy, AC2
Andoh, T; Anzai, K; Ide, T1
Duncan, PE; Griffin, JP; Solomon, SS1
Cake, MH; Litwack, G2
Bieck, P; Neuvonen, PJ; Vapaatalo, H; Westermann, E1
Howell, SL; Montague, W; Tyhurst, M1
Feldman, JF1
Tsuboi, M; Yanagishima, N2
Dickens, MS; Lucas-Leonard, J; Roth, JS1
Fink, CJ; Lacy, PE; McDaniel, ML; Roth, C1
Mattocks, AM; Wesley-Hadzija, B1
Newburgh, RW; Tsuzuki, J1
Nishigaki, I; Ohama, H; Okumura, M; Yagi, K1
Beatty, CH; Bocek, RM1
Karelin, AA; Mardashev, SR1
Gelman, DB; Hayes, DK; Schechter, MS1
Claycomb, WC1
Kahan, BD; Mittal, KK; Pincus, JH1
Beatty, CH; Bocek, RM; Novy, MJ; Young, MK1
Ehmann, UK; Gehring, U; Tomkins, GM1
Furihata, C; Matsushima, T; Sugimura, T; Terai, M1
Erlij, D; Grinstein, S1
Braun, R; Trevithick, JR1
Franks, DJ; Hamet, P; Horrobin, DF; Manku, MS1
Garbers, DL1
Scarpelli, DG; Tomita, T1
Bockaert, J; Perez, M; Premont, J1
Ozato, K1
Coult, DB; Wilkinson, RG1
Asano, T; Hidaka, H; Ochiai, Y1
Buckley, JT1
Finlayson, LH; Osborne, MP1
Cagan, RH1
Davidson, D; Stallwood, GR1
Bruyere, HJ; Cheung, MO; Gilbert, EF; Hodach, RJ; Ishikawa, S1
Dodd, G; Menevse, A; Poynder, TM1
Breuiller, M; Cedard, L; de Pariente, D; Ferre, F1
De Mello, WC1
Kostellow, AB; Morrill, GA; Poupko, JM; Schatz, F1
Higgens, CE; Somers, PJ1
Kirkpatrick, JR; Phillis, JW1
Lowitt, S; Polson, JB; Szentivanyi, A; Williams, JF1
Latarjet, R; Zajdela, F2
Grakhovska, T; Petkov, V; Stancheva, S; Uzunov, P1
Buse, E; Ebert, F; Walter, RD1
Butt, NM; Collier, HO; Cuthbert, NJ; Francis, DL; Saeed, SA1
Correze, C; Krug, E; Nunez, J; Verhaegen, M1
Soyka, LF2
Kidder, GW; Nolan, LL1
Goz, B; Hart, CA; Wharton, W1
Stefanovich, V2
Coret, IA; Hughes, MJ1
Balls, M; Gater, S1
Dewey, WC; Tomasovic, SP1
Connett, RJ; Hays, ET1
Brown, L; Horning, MG; Kellaway, P; Lertratanangkoon, K; Nowlin, J; Zion, TE1
Dascombe, MJ1
Fink, CJ; Lacy, PE; McDaniel, ML; Roth, CE; Swanson, JA; Weaver, DC1
Brodsky, B; Koup, JR1
Aranda, JV; Turmen, T1
Bry, CG; Fink, CJ; Homer, RW; Lacy, PE; McDaniel, ML1
Maziére, C; Maziére, JC1
Brazier, JL; Renaud, H; Ribon, B; Salle, BL1
Lin, CI; Vassalle, M1
Gan, IE; Schier, GM1
Bada, HS; Khanna, NN; Somani, SM; Tin, AA1
Götz von Olenhusen, KG; Wohlfarth-Bottermann, KE1
Farkas, CS1
Allan, WC; Volpe, JJ1
Baltassat, P; Bory, C; Frederich, A; Hartmann, E1
Alberola, S; Jeanjean, B; Sabon, F; Terol, A1
Shoyab, M1
O'Neill, FJ1
Aldridge, A; Aranda, JV; Haber, R; Louridas, AT; Thom, P; Vitullo, BB1
Dettmer, D; Glander, HJ1
Nielsen-Kudsk, F; Pedersen, AK1
Jhamandas, K; Sawynok, J; Sutak, M1
Riechert, M1
Al-Ani, NI; Borazan, HN2
Ido, T; Iwata, R; Kasida, Y; Saji, H; Suzuki, K; Tamate, K; Yoshikawa, K1
Göber, B; Kraft, R1
Timson, J2
Syed, IB1
Kihlman, BA; Sturelid, S1
Allewell, NM; Oles, J; Wolfe, J1
Cockett, AT; Dougherty, KA; Urry, RL1
Limpavithayakul, K; Lolikha, PH1
Dich, J; Gluud, CN1
Price, NR; Williams, AJ1
Sved, S; Wilson, DL1
Hossie, RD; McGilveray, IJ; Midha, KK; Sved, S1
Ohkawa, H; Watanabe, M1
Charles, BG; Rawal, BD2
Beubler, E; Lembeck, F1
Amerson, E; Cook, CE; Kepler, JA; Myers, M; Taylor, GF; Twine, ME1
Turner, T; Vasiliades, J1
Pichler, O; Studlar, M1
Kakac, B; Ryska, M; Sarsunova, M1
Chae, YS; Shelver, WH1
Chiou, WL; Peng, A; Peng, GW; Smith, V1
Hoffmann, A; Siegers, CP; Sierra-Callejas, JL; Strubelt, O1
Brunetti, T; Capolsini Secca, T; Ciucci Dolcini, BM; Dolcini, C; Fanò, G; Menchetti, O1
Ivy, N; Jemiolo, D; Mellon, M; Nath, J; Rebhun, LI1
Katz, ML; Kazmer, S; Mauer, I; Weinstein, D1
Lucey, JF1
Dusci, LJ; Hackett, LP; McDonald, IA1
Agnati, LF; Corrodi, H; Everitt, BJ; Fuxe, K; Hökfelt, T; Löfström, A; Ungerstedt, U1
Gombe, S; Norman, C1
Aeschbacher, HU; Würzner, HP1
Wildanger, W1
Lehmann, AR; Nilsson, K1
Frings, CS; Keefer, RC; Saloom, JM1
Chapman, RA; Leoty, C1
Holzhey, P1
Franconi, LC; Haney, WG; Hawk, GL; Sandmann, BJ1
Hossie, RD; McGilveray, IJ; Sved, S1
Johnson, GF; Least, CJ; Solomon, HM1
Evenson, MA; Warren, BL1
Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S1
Gonzalez, FJ; Gu, L; Kalow, W; Tang, BK1
Hiratsuka, E; Imamura, S; Kimura, M; Matsuoka, R; Takao, A1
Gadd, GM; Sabie, FT1
Hodgkiss, RJ; Kelleher, E; Parrick, J1
Suzuki, R; Yoshino, H1
Andersson, HC; Kihlman, BA1
Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D1
Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Osada, A; Tanaka, E; Tsuji, K; Yamamoto, Y1
Lerner, UH; Mellström, D1
Dean, PM; Edwardson, JM1
Duenas, J; Elizalde, A; Huerta, M; Muñiz, J; Trujillo, X1
Asahi, T; Kuribara, H; Tadokoro, S1
Anders, EM; Fuhr, U; Mahr, G; Sörgel, F; Staib, AH1
Cayre, I; Frutos, G; González-Jimènez, J1
Desta, Z; Steingruber, M1
Arizono, K; Brady, FO; Garrett, SH; Xiong, X1
Carnevale, A; Chiarotti, M; De Carolis, MP; De Giovanni, N; Muzii, U; Romagnoli, C; Tortorolo, G; Zecca, E1
Dudley, MN; Marchbanks, CR; Radandt, JM1
Blanchard, J; Shearer, LE; Weber, CW2
Robson, RA1
Brown, SS; Chin, KC; Durbin, GM; Hale, KA; Morgan, ME; Scanlon, JE1
Kuribara, H; Tadokoro, S1
Alsar, MJ; Sacristan, JA; Soto, J1
Fuhr, U; Roots, I; Rost, KL; Staib, AH1
Tanaka, E1
Misawa, M; Suzuki, T; Tuazon, DB; Watanabe, S1
Alderfer, JL; Brickmann, JA; Danilov, VI; Lautenschlager, P; Poltev, VI; Slyusarchuk, ON; Wollman, RM1
Caslavska, J; Gebauer, P; Minger, A; Molteni, S; Thormann, W1
Mante, S; Minneman, KP1
Ajiro, K; Nishikawa, Y; Shibata, K1
Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD1
Gellert, M; Menetski, JP1
Belan, PV; Kostyuk, PG; Tepikin, AV1
Battula, N; Doehmer, J; Fuhr, U; Keita, Y; Kudla, C; Staib, AH; Wölfel, C1
Huddart, H; Lynch, M1
Moncrieff, J1
Jackson, SH; Maskray, V; Swift, CG; Tiplady, B; Yu, G1
Levi-Schaffer, F; Touitou, E1
Gilbert, SG; Rice, DC1
Nasir, T; Zarrindast, MR1
Ferre, S; Guix, T; Jane, F; Limon, A; Parra, P1
Irani, AJ; Merchant, RH1
Mitsumoto, Y; Mohri, T; Ohkubo, T1
Andén, NE; Casas, M; Ferré, S; Grabowska-Andén, M; Herrera-Marschitz, M; Ungerstedt, U1
Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW1
Cortijo, J; Morcillo, EJ; Ortiz, JL; Sanz, CM1
Arzubiaga, C; Biaggioni, I; Paul, S; Puckett, A1
Buchmann, M; Kesselring, UW; Nam-Trân, H; Rey-Mermet, C; Ruelle, P1
Alken, RG; Hüller, H; Kowal, K; Migulla, H1
Dulloo, AG; Girardier, L; Seydoux, J2
Mehta, PN; Panitch, HB; Shaffer, TH; Wolfson, MR1
Carnevale, A; Chiarotti, M; De Carolis, MP; De Giovanni, N; Muzii, U; Romagnoli, C; Tortorolo, G1
Ståhle, L2
Segersvärd, S; Ståhle, L; Ungerstedt, U1
Kiss, T; Osipenko, ON1
Musk, SR; Steel, GG1
Jonkman, JH; Sauter, R; Sollie, FA; Steinijans, VW1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Duffy, P; Phillips, YY1
Peracchia, C2
Sacristán del Castillo, JA; Soto Alvarez, J1
Healy, DP; Polk, RE; Schoenle, JR; Stotka, J1
Broccali, G; Cesana, M; Crema, A; Imbimbo, BP1
Schouten, VJ1
Chang, CC; Hong, SJ; Huang, CY1
Dörner, K; Oldigs, HD; Schaub, J; Sievers, E1
Gülmez, I; Imamoğlu, A; Karacagil, M; Paşaoğlu, H; Tatlişen, A1
Johnson, DG; Levin, SR; Pai, G; Punzalan, R; Tung, P1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z1
Brabenec, A; Ganapathi, MK; Hu, SI; Kushner, I; Mackiewicz, A; Samols, D; Schultz, D1
Haginaka, J; Kimura, Y; Wakai, J; Yasuda, H1
Badia, A; Casas, M; Ferré, S; Guix, T; Herrera-Marschitz, M; Jané, F; Parra, P; Sallés, J; Ungerstedt, U1
Henderson, LA; Sarachek, A1
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Keim, SA; Klebanoff, MA2
Ali, A; O'Donnell, JM; Rutherfurd-Markwick, KJ; Starck, C1
Hanff, TC; Minor, TR1
Bregante, DT; Chan, SY; Dursch, TJ; Liu, DE; Oh, Y; Radke, CJ1
Barbisan, F; Bochi, GV; Cargnin, LP; da Cruz, IB; da Silva, AR; Kober, H; Moresco, RN; Ribeiro, EE; Sangoi, MB; Tatsch, E; Torbitz, VD1
Laing, T; Lake, BR; Mohamed, HA; Phillips, RM; Willans, CE1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR1
Lazenka, MF; Moeller, FG; Negus, SS1
Kato, S; Nakajima, H; Rang, Y; Uchiyama, K; Zeng, H1
Flesch, FM; Jordan, NY; Mimpen, JY; Torano, JS; van de Meent, MH; van den Bogaard, WJ1
Ballanyi, K; Kantor, C; Kilb, W; Kuribayashi, J; Luhmann, HJ; Mildenberger, E; Ruangkittisakul, A; Sharopov, S1
Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP1
Adehin, A; Bolaji, OO1
Basurto Ona, X; Bonfill Cosp, X; Osorio, D1
Alharbi, O; Goodacre, R; Xu, Y1
Baker, AM; Eichelberger, KY; Haeri, S; Strauss, RA; Stuebe, AM; Woodham, PC1
Campbell, SC; Clark, EA; Schoen, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Tak, C; Varner, MW; Yu, T1
Bhatt, P; Nanjundaiah, S; Rastogi, NK; Thakur, MS1
Cabral, FL; da Cruz, IB; da Silva, CB; Dos Santos, CB; Gonçalves, JF; Leal, DB; Lopes, ST; Machado, AK; Rezer, JF; Ruchel, JB; Schetinger, MR; Thorstenberg, ML1
Lopes, JA; Machado, S; Magalhães, LM; Páscoa, RN; Segundo, MA1
Francini, A; Pierattini, EC; Raffaelli, A; Sebastiani, L1
Alonso-Vicente, A; Bell, SE; Brady, AJ; Caffarel-Salvador, E; Donnelly, RF; Eltayib, E; Gonzalez-Vazquez, P; Jones, DS; McCarthy, HO; McCoy, CP; McElnay, JC; Meng, T; Mooney, K; Torrisi, BM; Vicente-Perez, EM1
Bulatov, A; Kirsanov, D; Medinskaia, K; Nikolaeva, L; Timofeeva, I1
Chia, HY; Ho, HK; Yau, WP1
Franco, R; Martínez-Pinilla, E; Oñatibia-Astibia, A2
Bergdahl, E; Sundqvist, KG; Talme, T1
Lightstone, FC; Navid, A; Ng, DM; Wong, SE1
Zidek, W1
Aswini, KK; Biju, VM; Vinu Mohan, AM1
Mitchell, EM; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Schliep, KC; Sjaarda, LA; Wactawski-Wende, J; Zarek, SM1
Chiba, K; Haraya, K; Kato, M; Sugiyama, Y1
Chan, SA; Lian, L; Pang, W; Song, W; Yao, B; Yin, D1
Alves, MG; Monteiro, JP; Oliveira, PF; Silva, BM1
Düe, M; Kaiser, S; Kietzmann, M; Koppe, S; Machnik, M; Schänzer, W; Schenk, I; Thevis, M; Toutain, PL1
Adamski, J; Artati, A; Bochud, M; Cornelis, MC; Eap, CB; Ehret, G; Friedrich, N; Ganna, A; Grabe, HJ; Guessous, I; Gustafsson, S; Homuth, G; Ingelsson, E; Kacprowski, T; Lind, L; Magnusson, PK; Mangino, M; Menni, C; Pedersen, NL; Pietzner, M; Pivin, E; Spector, TD; Suhre, K; Völzke, H1
Abdalla, FH; Adefegha, SA; Braun, JBS; Castilhos, LG; da Silva, CB; de Oliveira, JS; Guedes Manzoni, A; Leal, DBR; Lopes, STA; Rubin, MA; Ruchel, JB; Signor, C; Trelles, K1
Onland, W; Ten Hove, CH; van Kaam, AH; Vliegenthart, RJ1
Churakov, AV; Drozd, KV; Manin, AN; Perlovich, GL1
Kuentz, M; Moog, R; Rothenhäusler, B; Schumacher, SU; Thun, J; Willmann, A1
Byrne, PG; Keogh, LM; Silla, AJ1
Cheng, RKY; Cooke, RM; Deflorian, F; Doré, AS; Errey, JC; Fiez-Vandal, C; Marshall, FH; Robertson, N; Segala, E1
Bodmeier, R; Kolbina, M; Körber, M1
Cáceres, N; Dafouz, R; Rodríguez-Gil, JL; Valcárcel, Y1
Arora, KK; Duggirala, NK; Krzyzaniak, JF; Suryanarayanan, R; Vyas, A1
Ding, Y; Hu, P; Li, L; Wang, Y1
Canuto, KM; Coutinho, JP; da Silva, GS; de Brito, ES; de Jesus, RM; Nascimento, MM; Ribeiro, PRV; Zocolo, GJ1
Oellig, C; Schunck, J; Schwack, W1
Bender, M; Bunz, UHF; Hahn, S; Han, J; Seehafer, K; Wang, B1
Chen, C; Feng, S; Que, L; Wang, W1
Bertol, E; Fais, P; Pascali, JP; Vaiano, F1
Dursun, Z; Kantekin, H; Koçak, ÇC; Nas, A1
Curulli, A; Marrosu, G; Petrucci, R; Zollo, G1
Ma, C; Wang, H; Xia, T; Zhou, B1
Dong, ZB; Liang, YR; Lu, J; Ma, YX; Wu, HS; Wu, XH; Ye, JH; Zheng, XQ1
Ishii, R; Kasai, T; Kosaka, T; Mizuno, T; Ohmichi, T; Shikata, K; Shinomoto, M; Tatebe, H; Tokuda, T1
Stove, CP; Velghe, S1
da Silva Morrone, M; de Mattos Pereira, L; Fonseca Moreira, JC; Giongo, A; Kich Grun, L; Kleber Silveira, A; Mautone Gomes, H; Moresco, KS; Pens Gelain, D; Rodrigues De Oliveira, R1
Le, N; Ness, GL; Singleton, EL1
Banipal, PK; Banipal, TS; Beri, A1
Holdsworth, CI; Lim, KF1
Bartella, L; Di Donna, L; Mazzotti, F; Napoli, A; Siciliano, C; Sindona, G1
Canotilho, J; Castro, RAE; Eusébio, MES; Évora, AOL; Maria, TMR; Ramos Silva, M1
Anastasiadi, RM; Berti, F; Di Tommaso, D; Peressi, M; Pividori, M; Redivo, L; Resmini, M1
Nagy, S; Pál, S; Salem, A; Széchenyi, A1
Macedo, GA; Santana, ÁL1
Birman, Y; Butko, MT; Khorsand, S; Mortensen, RB; Tu, E1
Abdalla, FH; Bernardes, VM; Braun, JBS; Casali, EA; Castilhos, LG; da Cruz, IBM; de Andrade, CM; de Oliveira, JS; Leal, DBR; Manzoni, AG; Passos, DF; Ruchel, JB1
Fávaro-Trindade, CS; Genovese, MI; Holkem, AT; Pinho, LS; Silva, MP; Thomazini, M1
Coelho, M; Cunha, RA; Manadas, B; Mendes, VM; Tomé, AR1
Hertzsch, R; Richter, A1
Ammer, H1
Assi, N; Boeing, H; Boutron-Ruault, MC; Casagrande, C; Ferrari, P; Jenab, M; Katzke, V; Keski-Rahkonen, P; Krogh, V; Kühn, T; Mahamat-Saleh, Y; Mancini, FR; Mattiello, A; Niforou, K; Palli, D; Robinot, N; Rothwell, JA; Sacerdote, C; Scalbert, A; Trichopoulou, A; Tumino, R; Valanou, E1
Deprez, S; Paniagua-González, L; Stove, CP; Velghe, S1
da Cruz, IBM; Dalcin, AJF; Gomes, P; Mitjans, M; Ourique, AF; Ribeiro, EE; Roggia, I; Vinardell, MP1
Li, X; Ma, C; Ren, X; Wu, Y; Xia, T; Zhou, B1
Ahmad, N; Ahmad, R; Al-Anaki, WS; Al-Jishi, F; Ismail, FA1
de Camargo, AC; Pinaffi, ACDC; Sampaio, GR; Shahidi, F; Soares, MJ; Torres, EAFS1
Abushanab, D; Al-Badriyeh, D; Al-Shaibi, S; Alhersh, E1
Hu, B; Huang, Z; Li, ZM; Wu, L; Yuan, ZC1
Campíns-Falcó, P; Herráez-Hernández, R; Ponce-Rodríguez, HD; Verdú-Andrés, J1
Chagas Junior, GCA; Ferreira, NR; Gloria, MBA; Lopes, AS; Martins, LHDS1
Chen, WL; Wu, SE1
Adomavičiūtė, S; Šablinskas, V; Velička, M; Zacharovas, E1
Hillier, J; Jones, EY; Lu, W; Ren, J; Zhao, Y1
Foroughi, MM; Jahani, S; Nia, NA1
Bachmann, CM; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Seyfried, M1
Cao, Y; Guan, Q; Guo, H; Wang, M; Wu, N; Xue, R; Yang, W; Zhao, X1
Bachmann, CM; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA1
Amyx, M; Bever, AM; Buck Louis, GM; Gerlanc, N; Gleason, JL; Grantz, KL; Hinkle, SN; Kannan, K; Robinson, M; Smarr, MM; Sundaram, R; Tekola-Ayele, F; Vafai, Y1
Alexander-White, C; Bury, D; Clewell, HJ; Cronin, M; Desprez, B; Detroyer, A; Efremenko, A; Firman, J; Hack, E; Hewitt, NJ; Kenna, G; Klaric, M; Lester, C; Mahony, C; Ouedraogo, G; Paini, A; Schepky, A1
Critchley, D; Tayo, B; Thai, C1
Kunisaki, KM; Sin, DD1
Goessler, W; Lajin, B; Obermayer-Pietsch, B; Schweighofer, N1
Kan, K; Kimura, K; Sasamoto, T; Shindo, T; Tanaka, T1
Chen, Y; Geng, F; Guo, C; Li, B; Li, J1
Ackermann, D; Ansermot, N; Bochud, M; Dhayat, NA; Eap, CB; Ehret, G; Estoppey-Younès, S; Guessous, I; Martin, PY; Melgarejo, JD; Petrovic, D; Ponte, B; Pruijm, M; Staessen, JA; Stringhini, S; Thijs, L; Vogt, B; Zhang, Z1
Guedez, A; Ryu, Y; Sherman, M1
Abitbol, CL; Ambalavanan, N; Askenazi, DJ; Charlton, JR; Guillet, R; Harer, MW; Jetton, JG; Kent, AL; Mhanna, MJ; Reidy, K; Selewski, DT; Starr, MC; Tipple, TE1
Kertys, M; Kmeťová, K; Maráková, K; Mokrý, J; Pršo, K; Žideková, N1
Celedón, JC; Forno, E; Han, YY1
Bileck, A; Brunmair, J; Feuerstein, ML; Gerner, C; Gotsmy, M; Janker, L; Langbauer, C; Meier-Menches, SM; Neuditschko, B; Niederstaetter, L; Slany, A; Zanghellini, J1
Guan, W; Mumford, SL; Polinski, KJ; Purdue-Smithe, A; Robinson, SL; Schisterman, EF; Schliep, KC; Silver, RM; Yeung, EH; Zhao, SK1
Arcega-Cabrera, F; Herrera-Silveira, J; Lamas-Cosío, E; León-Aguirre, K; Martínez-Casales, Y; Noreña-Barroso, E1
Huang, PJ; Liu, J1
Altikatoglu Yapaoz, M; Attar, A1
Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J1
Daali, Y; Desmeules, J; Magliocco, G; Samer, CF; Thomas, A1
Bryce, DL; Southern, SA1
Bai, L; Chen, Z; Cheng, X; Ding, Y; Hu, M; Hu, X; Hu, Y; Huang, Y; Li, H; Liao, R; Qu, W; She, ZG; Tian, S; Wan, J; Xue, J; Zhang, X; Zhang, XJ; Zhang, Y; Zhao, J; Zou, T1
Kinzig, M; Pietrzak-Fiećko, R; Purkiewicz, A; Sörgel, F1
Dirikolu, L; Göktaş, EF; Güneş, E; Kabil, E; Yatanaslan, L1
Chen, F; Cheng, R; Dai, HR; Ding, XS; Du, FF; Guo, HL; Hu, YH; Long, JY; Tian, M; Xia, Y; Xu, J1
Labas, SR; Liu, J1
Aoyama, K; Bhadhprasit, W; Kinoshita, C; Matsumura, N; Nakaki, T1
Cao, D; Han, R; Liu, D; Wan, Z; Wang, Y; Xie, F; Yu, Z; Zeng, N1
Eguchi, H; Endo, S; Ikari, A; Ito, A; Kimura, R; Matsunaga, T; Onuma, S; Yoshino, Y; Yu, Y1
Liu, M; Luo, J; Xie, R; Zhang, Y; Zheng, Z1
Arlt, C; Günther, WF; Hüttelmaier, S; Kipping, M; Lederer, M; Merkenschlager, A; Sinz, A; Tänzler, D1
Beardsley, PM; Elder, HJ; Walentiny, DM1
Ding, Y; Huang, PJ; Li, AZ; Liu, J; Xie, Y1
Aoyama, K; Matsumura, N1
Dieckmann, T; Evans, NM; Huang, PJ; Li, AZ; Liu, J; Lu, C1
Bortolami, M; Curulli, A; Di Matteo, P; Feroci, M; Petrucci, R; Trani, A1
Bruschettini, M; Marques, KA; Moresco, L; Sjögren, A; Soll, R1
Liu, M; Shen, W; Tan, N; Tang, M; Zhang, Y1

Reviews

112 review(s) available for caffeine and theophylline

ArticleYear
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship

1992
Adenosine receptors: targets for future drugs.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1982
Fluorescent ligands for adenosine receptors.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1

2013
Adenosine A2A receptor as a drug discovery target.
    Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9

    Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction

2014
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
    European journal of medicinal chemistry, 2022, Jan-05, Volume: 227

    Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship

2022
[Parotid secretion and its pharmacologically induced variants (author's transl)].
    HNO, 1975, Volume: 23, Issue:8

    Topics: Adrenergic beta-Antagonists; Amylases; Animals; Antihypertensive Agents; Caffeine; Cyclic AMP; Dinitrophenols; Humans; Nicotine; Oxidative Phosphorylation; Parotid Gland; Receptors, Adrenergic; Sialadenitis; Sympathomimetics; Theophylline

1975
Opiates, cyclic nucleotides, and xanthines.
    Advances in biochemical psychopharmacology, 1976, Volume: 15

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caffeine; Cyclic AMP; Dopamine; Enzyme Activation; Humans; Lung; Morphine; Narcotics; Prostaglandins E; Theophylline; Xanthines

1976
Effects of methylxanthines on the fetus.
    Clinics in perinatology, 1979, Volume: 6, Issue:1

    Topics: Animals; Caffeine; Cyclic AMP; Female; Fetus; Humans; Intestinal Absorption; Kinetics; Labor, Obstetric; Lung; Maternal-Fetal Exchange; Pregnancy; Respiration; Theophylline; Xanthines

1979
Methylxanthines in apnea of prematurity.
    Clinics in perinatology, 1979, Volume: 6, Issue:1

    Topics: Apnea; Caffeine; Hemodynamics; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Respiration; Theophylline

1979
Theobromine and theophylline.
    Mutation research, 1975, Volume: 32, Issue:2

    Topics: Animals; Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosomes; Drosophila; Escherichia coli; Humans; Mice; Mitosis; Mutagens; Mutation; Rats; Structure-Activity Relationship; Theobromine; Theophylline

1975
The effects of caffeine.
    Journal of the American Pharmaceutical Association, 1976, Volume: 16, Issue:10

    Topics: Adult; Arteriosclerosis; Caffeine; Child, Preschool; Female; Humans; Hypersensitivity; Infant; Male; Middle Aged; Theobromine; Theophylline; Time Factors

1976
Regulation of the in vivo mitotic apparatus by glycols and metabolic inhibitors.
    Annals of the New York Academy of Sciences, 1975, Jun-30, Volume: 253

    Topics: Aminophylline; Animals; Bivalvia; Brain; Caffeine; Calcium; Colchicine; Dinitrophenols; Female; Glycols; Microtubules; Mitosis; Organoids; Ovum; Rabbits; Sea Urchins; Theophylline; Tubulin; Xanthines

1975
Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 14, Issue:1

    Topics: Absorption; Antacids; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interactions; Food; Humans; Metronidazole; Theophylline

1992
The effects of quinolones on xanthine pharmacokinetics.
    The American journal of medicine, 1992, Apr-06, Volume: 92, Issue:4A

    Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Drug Interactions; Humans; Theophylline; Xanthines

1992
Pharmacotherapy of neonatal apnea.
    Indian pediatrics, 1991, Volume: 28, Issue:11

    Topics: Apnea; Caffeine; Citrates; Doxapram; Drug Combinations; Humans; Infant, Newborn; Theophylline

1991
[Gyrase inhibitors. Central nervous side effects and inhibition of methylxanthine elimination].
    Deutsche medizinische Wochenschrift (1946), 1990, Feb-16, Volume: 115, Issue:7

    Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Central Nervous System; Drug Interactions; Drug Synergism; Humans; Theophylline; Xanthines

1990
Adverse reactions and interactions of fluoroquinolones.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1989, Volume: 12, Issue:1

    Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Drug Interactions; Humans; Intestinal Absorption; Mutagens; Theophylline

1989
Drug-drug interactions with ciprofloxacin and other fluoroquinolones.
    The American journal of medicine, 1989, Nov-30, Volume: 87, Issue:5A

    Topics: Antacids; Caffeine; Ciprofloxacin; Cyclosporins; Drug Interactions; Humans; Intestinal Absorption; Rifampin; Theophylline

1989
Effects of enprofylline and theophylline may show the role of adenosine.
    Life sciences, 1986, Mar-24, Volume: 38, Issue:12

    Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesterified; Gastric Acid; Heart; Humans; Kidney; Kinetics; Lung; Natriuresis; Phosphodiesterase Inhibitors; Receptors, Cell Surface; Receptors, Purinergic; Respiration; Seizures; SRS-A; Theophylline; Vasoconstriction; Vasodilation; Xanthines

1986
Pharmacotherapy of respiratory muscles.
    Clinics in chest medicine, 1988, Volume: 9, Issue:2

    Topics: Animals; Caffeine; Humans; Muscle Contraction; Respiratory Insufficiency; Respiratory Muscles; Stimulation, Chemical; Sympathomimetics; Theophylline

1988
Pharmacologic effects of theophylline in the newborn.
    The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:4 Pt 2

    Topics: Animals; Animals, Newborn; Brain; Caffeine; Cardiovascular System; Digestive System; Hormones; Humans; Infant, Newborn; Kidney; Respiratory System; Theophylline

1986
[Nucleotide metabolism and gastric acid secretion].
    Klinische Wochenschrift, 1970, Jul-15, Volume: 48, Issue:14

    Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Cortisone; Cyclic AMP; Depression, Chemical; Dogs; Epinephrine; Gastric Juice; Gastric Mucosa; Glucocorticoids; Guinea Pigs; Histamine Release; Humans; Hydrazines; Imidazoles; In Vitro Techniques; Phentolamine; Phosphates; Phosphoric Monoester Hydrolases; Prednisolone; Propiophenones; Prostaglandins; Rabbits; Rats; Stimulation, Chemical; Sympatholytics; Theobromine; Theophylline; Vasodilator Agents

1970
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
    Mutation research, 1974, Volume: 23, Issue:2

    Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines; DNA; DNA Repair; DNA Replication; DNA, Single-Stranded; Floxuridine; Hydroxyurea; Mitosis; Models, Biological; Mutagens; Radiation Genetics; Recombination, Genetic; Streptonigrin; Theobromine; Theophylline

1974
Cyclic nucleotide phosphodiesterase.
    Advances in biochemical psychopharmacology, 1970, Volume: 3

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Brain; Caffeine; Cyclic AMP; Diphosphates; Enzyme Activation; Insulin; Kinetics; Magnesium; Manganese; Molecular Weight; Phosphoric Monoester Hydrolases; Theophylline; Trypsin

1970
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.
    Federation proceedings, 1973, Volume: 32, Issue:7

    Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Phentolamine; Propranolol; Receptors, Adrenergic; Stress, Physiological; Sympathetic Nervous System; Theophylline

1973
The positive inotropic effect of cyclic AMP.
    Advances in cyclic nucleotide research, 1972, Volume: 1

    Topics: Aminophylline; Animals; Butyrates; Caffeine; Cyclic AMP; Epinephrine; Glucagon; Guinea Pigs; Heart; Histamine; Isoproterenol; Lysergic Acid Diethylamide; Models, Biological; Muscle Contraction; Myocardium; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Rats; Theophylline; Time Factors; Tritium

1972
Cyclic nucleotides in higher plants?
    Advances in cyclic nucleotide research, 1974, Volume: 4, Issue:0

    Topics: Adenine; Adenosine; Adenylyl Cyclases; Caffeine; Cyclic AMP; Gibberellins; Phosphoric Diester Hydrolases; Plant Growth Regulators; Plants; Protein Kinases; Theophylline

1974
Drug treatment in bronchial asthma.
    Seminars in drug treatment, 1973,Spring, Volume: 2, Issue:4

    Topics: Acetylcysteine; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Caffeine; Drug Combinations; Ephedrine; Epinephrine; Expectorants; Glucocorticoids; Guaifenesin; Humans; Hypertension; Isoproterenol; Mucus; Sympathomimetics; Theophylline; Xanthines

1973
Effects of caffeine on the genetic material.
    Mutation research, 1974, Volume: 26, Issue:2

    Topics: Alkylating Agents; Animals; Ascomycota; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Coffee; DNA Replication; Drug Synergism; Environmental Exposure; Escherichia coli; Humans; Meiosis; Mutagens; Mutation; Radiation Effects; Tea; Theophylline; Ultraviolet Rays

1974
Gastrointestinal and metabolic effects of methylxanthines.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Caffeine; Calcium; Carbohydrate Metabolism; Digestive System; Energy Metabolism; Esophagus; Gastric Acid; Humans; Lipid Metabolism; Lipolysis; Liver; Pancreas; Saliva; Theophylline; Thyroid Gland; Xanthines

1984
Effects of methylxanthines on skeletal muscle and on respiration.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Animals; Caffeine; Histamine Release; Muscle Contraction; Muscles; Respiration; Theobromine; Theophylline

1984
Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines.
    Life sciences, 1981, May-11, Volume: 28, Issue:19

    Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System; Cyclic AMP; Humans; Neurotransmitter Agents; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Xanthines

1981
Theophylline reassessed.
    Annals of internal medicine, 1984, Volume: 101, Issue:1

    Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline

1984
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.
    Molecular and cellular endocrinology, 1981, Volume: 23, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Isoenzymes; Phosphodiesterase Inhibitors; Theophylline; Xanthines

1981
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.
    Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 16

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Caffeine; Cells, Cultured; Humans; Kinetics; Leukemia; Lymphocyte Activation; Lymphocytes; Reference Values; Theophylline

1984
The neuropharmacology of various diazepam antagonists.
    Neuropharmacology, 1983, Volume: 22, Issue:12B

    Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline

1983
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
    Drug metabolism reviews, 1983, Volume: 14, Issue:2

    Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Kinetics; Male; Methylation; Pulmonary Edema; Theophylline; Tissue Distribution

1983
Caffeine: implications of recent research for clinical practice.
    The American journal of orthopsychiatry, 1984, Volume: 54, Issue:3

    Topics: Abnormalities, Drug-Induced; Affective Symptoms; Animals; Blood Pressure; Brain; Caffeine; Child; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Male; Motor Activity; Pregnancy; Stimulation, Chemical; Substance-Related Disorders; Theophylline

1984
Analytical methods for quantitation of methylxanthines.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Animals; Body Fluids; Caffeine; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Food Analysis; Humans; Methods; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

1984
Human disposition and some biochemical aspects of methylxanthines.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Caffeine; Contraceptives, Oral; Female; Humans; Intestinal Absorption; Kinetics; Male; Theobromine; Theophylline; Tissue Distribution

1984
Action of the methylxanthines on the pituitary and pituitary-dependent hormones.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Adrenal Glands; Animals; Caffeine; Female; Growth Hormone; Humans; Male; Pituitary Gland; Prolactin; Theobromine; Theophylline; Thyroid Gland; Thyrotropin; Time Factors

1984
Introduction to the chemistry, isolation, and biosynthesis of methylxanthines.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Cacao; Caffeine; Chemical Phenomena; Chemistry; Coffee; Tea; Theobromine; Theophylline

1984
The chemical components of coffee.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Alkaloids; Caffeine; Carbohydrates; Coffee; Hydrocarbons; Lipids; Mycotoxins; Nitrogen; Pesticides; Phenols; Sulfur; Theobromine; Theophylline; Vitamins

1984
The toxicology of cocoa and methylxanthines: a review of the literature.
    Critical reviews in toxicology, 1982, Volume: 9, Issue:4

    Topics: Animals; Cacao; Caffeine; Diet; Female; Fetus; Fibrocystic Breast Disease; Humans; Mutagenicity Tests; Plants, Edible; Reproduction; Theobromine; Theophylline; Tissue Distribution; Xanthines

1982
The biochemistry and technology of tea manufacture.
    Critical reviews in food science and nutrition, 1980, Volume: 12, Issue:4

    Topics: Alkaloids; Caffeine; Catechin; Fermentation; Food Handling; Food Technology; Hot Temperature; Nitrogen; Oils, Volatile; Plant Proteins; Species Specificity; Tannins; Tea; Theobromine; Theophylline

1980
Transdermal delivery and the premature neonate.
    Critical reviews in therapeutic drug carrier systems, 1994, Volume: 11, Issue:1

    Topics: Administration, Cutaneous; Administration, Oral; Animals; Caffeine; Drug Delivery Systems; Female; Humans; Infant, Newborn; Infant, Premature; Injections, Intravenous; Male; Skin; Skin Absorption; Theophylline

1994
Receptor mechanisms of bitter substances.
    Physiology & behavior, 1994, Volume: 56, Issue:6

    Topics: Amino Acid Sequence; Animals; Caffeine; GTP-Binding Proteins; Humans; Molecular Sequence Data; Quinine; Receptors, Cell Surface; RNA, Messenger; Strychnine; Synaptic Transmission; Taste; Taste Buds; Theophylline

1994
Pharmacological stimulation of sperm motility.
    Human reproduction (Oxford, England), 1994, Volume: 9, Issue:2

    Topics: Caffeine; Deoxyadenosines; Humans; Infertility, Male; Male; Pentoxifylline; Relaxin; Sperm Motility; Theophylline

1994
Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine.
    Archives of pediatrics & adolescent medicine, 1996, Volume: 150, Issue:3

    Topics: Adolescent; Adolescent Behavior; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Child; Child Behavior; Cognition; Female; Humans; Male; Theophylline

1996
Pharmacologic management of apnea of prematurity.
    The Journal of perinatal & neonatal nursing, 1996, Volume: 9, Issue:4

    Topics: Apnea; Bronchodilator Agents; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline

1996
Pharmacokinetic interactions related to the chemical structures of fluoroquinolones.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 37 Suppl A

    Topics: Aluminum Hydroxide; Animals; Anti-Infective Agents; Caffeine; Drug Interactions; Fluoroquinolones; Humans; Molecular Structure; Quinolones; Rats; Structure-Activity Relationship; Theophylline

1996
Standards of laboratory practice: theophylline and caffeine monitoring. National Academy of Clinical Biochemistry.
    Clinical chemistry, 1998, Volume: 44, Issue:5

    Topics: Apnea; Bronchodilator Agents; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Lung Diseases, Obstructive; Quality Control; Specimen Handling; Theophylline

1998
[Pharmacokinetic interactions between fluoroquinolones and methylxanthines].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1999, Volume: 44, Issue:3

    Topics: Anti-Infective Agents; Caffeine; Drug Interactions; Fluoroquinolones; Humans; Methylation; Theophylline; Xanthines

1999
Caffeine versus theophylline for apnea in preterm infants.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline

2000
Prophylactic methylxanthine for extubation in preterm infants.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Caffeine; Central Nervous System Agents; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Intubation, Intratracheal; Theophylline; Vasodilator Agents; Ventilator Weaning; Xanthines

2000
Methylxanthine treatment for apnea in preterm infants.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Vasodilator Agents; Xanthines

2000
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Stroke; Theophylline; Vasodilator Agents

2000
Current options in the management of apnea of prematurity.
    Clinical pediatrics, 2000, Volume: 39, Issue:6

    Topics: Apnea; Caffeine; Central Nervous System Stimulants; Doxapram; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Xanthines

2000
[Simultaneous determination of theophylline and its metabolites by HPLC].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2000, Volume: 120, Issue:10

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Sensitivity and Specificity; Theophylline; Xanthines

2000
Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:7

    Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Dogs; Humans; Mice; Models, Biological; Pharmacokinetics; Probability; Rabbits; Rats; Reproducibility of Results; Risk Assessment; Species Specificity; Substrate Specificity; Theobromine; Theophylline

2001
Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:7

    Topics: Adult; Aged; Area Under Curve; Caffeine; Child; Cytochrome P-450 CYP1A2; Humans; Infant, Newborn; Models, Biological; Pharmacokinetics; Probability; Reproducibility of Results; Risk Assessment; Substrate Specificity; Theobromine; Theophylline; Warfarin

2001
Methylxanthine treatment for apnea in preterm infants.
    The Cochrane database of systematic reviews, 2001, Issue:3

    Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline; Vasodilator Agents; Xanthines

2001
Theophylline or caffeine: which is best for apnea of prematurity?
    Neonatal network : NN, 2000, Volume: 19, Issue:8

    Topics: Apnea; Caffeine; Citrates; Drug Combinations; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male; Theophylline; Treatment Outcome

2000
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.
    Journal of occupational and environmental medicine, 2002, Volume: 44, Issue:5

    Topics: Amphetamine; Amphetamines; Benzphetamine; Caffeine; Furans; Humans; Methamphetamine; Molecular Structure; Prenylamine; Prodrugs; Pyrazoles; Pyrazolones; Selegiline; Substance Abuse Detection; Sydnones; Theophylline

2002
The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent.
    Obesity reviews : an official journal of the International Association for the Study of Obesity, 2001, Volume: 2, Issue:3

    Topics: Aminophylline; Animals; Caffeine; Ephedrine; Humans; Obesity; Plant Preparations; Theophylline; Weight Loss

2001
Augmentation of seizure induction in electroconvulsive therapy: a clinical reappraisal.
    The journal of ECT, 2002, Volume: 18, Issue:3

    Topics: Anesthetics; Caffeine; Electroconvulsive Therapy; Humans; Oxygen; Psychotropic Drugs; Theophylline

2002
Prophylactic methylxanthines for extubation in preterm infants.
    The Cochrane database of systematic reviews, 2003, Issue:1

    Topics: Caffeine; Central Nervous System Agents; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Intubation, Intratracheal; Randomized Controlled Trials as Topic; Theophylline; Time Factors; Vasodilator Agents; Ventilator Weaning; Xanthines

2003
Treatment of apnea of prematurity.
    Paediatric drugs, 2003, Volume: 5, Issue:3

    Topics: Aminophylline; Apnea; Caffeine; Clinical Trials as Topic; Doxapram; Humans; Infant, Newborn; Infant, Premature; Respiratory System Agents; Theophylline

2003
[CATECHOLAMINES AND CARDIAC MUSCLE].
    Revue canadienne de biologie, 1963, Volume: 22

    Topics: Acetylcholine; Adenine Nucleotides; Caffeine; Calcium; Catecholamines; Glycogen; Guanethidine; Heart; Hyperthyroidism; Isoproterenol; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Perfusion; Pharmacology; Phosphorylase Kinase; Piperazines; Research; Reserpine; Strophanthins; Sympathetic Nervous System; Theophylline; Tyramine

1963
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
    Journal of toxicology and environmental health. Part A, 2004, Feb-27, Volume: 67, Issue:4

    Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic Clearance Rate; Models, Biological; Risk Factors; Theophylline; Tissue Distribution

2004
Methylxanthines for the treatment of apnea associated with bronchiolitis and anesthesia.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:7

    Topics: Anesthesia, General; Apnea; Bronchiolitis; Caffeine; Clinical Trials as Topic; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Respiratory System Agents; Theophylline

2004
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
    The Cochrane database of systematic reviews, 2004, Issue:3

    Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Randomized Controlled Trials as Topic; Stroke; Theophylline; Vasodilator Agents

2004
Assessment of CYP1A2 activity in clinical practice: why, how, and when?
    Basic & clinical pharmacology & toxicology, 2005, Volume: 97, Issue:3

    Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Induction; Genotype; Humans; Liver; Pharmaceutical Preparations; Phenotype; Saliva; Theophylline

2005
Drug interactions and smoking: raising awareness for acute and critical care providers.
    Critical care nursing clinics of North America, 2006, Volume: 18, Issue:1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Anticoagulants; Caffeine; Critical Care; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Drug Resistance; Humans; Liver; Metabolic Clearance Rate; Nurse's Role; Nursing Assessment; Prevalence; Psychotropic Drugs; Smoking; Theophylline; United States

2006
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.
    Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:2

    Topics: Administration, Oral; ATP-Binding Cassette Transporters; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Pharmaceutical Preparations; Phenotype; Theophylline; Tolbutamide

2007
Drug interactions with smoking.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2007, Sep-15, Volume: 64, Issue:18

    Topics: Benzodiazepines; Caffeine; Clozapine; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Drug Interactions; Humans; Olanzapine; Smoking; Theophylline

2007
Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
    Clinical pharmacokinetics, 2008, Volume: 47, Issue:1

    Topics: Administration, Oral; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Clinical Trials as Topic; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Midazolam; Mixed Function Oxygenases; Modafinil; Pharmaceutical Preparations; Theophylline

2008
[Coffee and cancer].
    Medicina clinica, 2008, Nov-08, Volume: 131, Issue:16

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Anticarcinogenic Agents; Caffeine; Cell Transformation, Neoplastic; Coffee; Female; Humans; Lymphocyte Activation; Male; Mice; Mice, Transgenic; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Adenosine A2; Theobromine; Theophylline

2008
Effects of caffeine and theophylline on coronary hyperemia induced by adenosine or dipyridamole.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2009, Oct-01, Volume: 74, Issue:4

    Topics: Adenosine; Animals; Caffeine; Coronary Circulation; Coronary Disease; Dipyridamole; Drug Administration Schedule; Drug Interactions; Echocardiography, Doppler; Humans; Hyperemia; Myocardial Perfusion Imaging; Positron-Emission Tomography; Practice Guidelines as Topic; Predictive Value of Tests; Theophylline; Time Factors; Vasodilator Agents

2009
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3

    Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissue Growth Factor; Humans; Liver; Liver Neoplasms; Proteasome Endopeptidase Complex; Smad2 Protein; Theophylline; Transforming Growth Factor beta; Xanthines

2009
Caffeine versus theophylline for apnea in preterm infants.
    The Cochrane database of systematic reviews, 2010, Jan-20, Issue:1

    Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Theophylline

2010
Distribution, biosynthesis and catabolism of methylxanthines in plants.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Amino Acid Sequence; Cacao; Caffeine; Camellia; Coffea; Methyltransferases; Molecular Sequence Data; Plants; Theophylline; Xanthines

2011
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Catalytic Domain; Drug Design; Humans; Phosphodiesterase Inhibitors; Theophylline; Xanthines

2011
Xanthines as adenosine receptor antagonists.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Caffeine; Humans; Purinergic P1 Receptor Antagonists; Species Specificity; Structure-Activity Relationship; Theophylline; Xanthines

2011
Methylxanthines, seizures, and excitotoxicity.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Adenosine; Animals; Caffeine; Humans; Neurotoxins; Seizures; Theophylline; Xanthines

2011
Methylxanthines and the kidney.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Animals; Caffeine; Contrast Media; Diuresis; Hemodynamics; Humans; Kidney; Natriuresis; Renin; Theophylline

2011
Methylxanthines and inflammatory cells.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theophylline

2011
Methylxanthine treatment for apnoea in preterm infants.
    The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12

    Topics: Apnea; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intermittent Positive-Pressure Ventilation; Randomized Controlled Trials as Topic; Theophylline; Vasodilator Agents; Xanthines

2010
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
    The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12

    Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Recurrence; Theophylline; Xanthines

2010
[Prophylaxis and therapy of postdural puncture headache--a critical evaluation of treatment options].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2011, Volume: 46, Issue:7-8

    Topics: Adrenocorticotropic Hormone; Adult; Analgesics; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Female; Humans; Injections, Spinal; Morphine; Post-Dural Puncture Headache; Pregnancy; Serotonin Antagonists; Theophylline; Vasodilator Agents

2011
Drug therapy for treating post-dural puncture headache.
    The Cochrane database of systematic reviews, 2011, Aug-10, Issue:8

    Topics: Adrenocorticotropic Hormone; Amines; Analgesics; Caffeine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Male; Pain Measurement; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture; Sumatriptan; Theophylline; Treatment Outcome

2011
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:6

    Topics: Adolescent; Adult; Caffeine; Clozapine; Computer Simulation; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Humans; Liver; Male; Middle Aged; Models, Biological; Serotonin 5-HT2 Receptor Agonists; Smoking; Theophylline; Young Adult

2012
Measurement of CYP1A2 activity: a focus on caffeine as a probe.
    Current drug metabolism, 2012, Jun-01, Volume: 13, Issue:5

    Topics: Animals; Breath Tests; Caffeine; Cytochrome P-450 CYP1A2; Humans; Saliva; Theobromine; Theophylline

2012
[Post-dural puncture headache].
    Der Anaesthesist, 2013, Volume: 62, Issue:2

    Topics: Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Humans; Morphine; Needles; Post-Dural Puncture Headache; Theophylline; Vasodilator Agents

2013
Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.
    Paediatric drugs, 2014, Volume: 16, Issue:2

    Topics: Apnea; Caffeine; Central Nervous System Stimulants; Citrates; Drug Monitoring; Humans; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Theophylline

2014
Safety considerations for patients with epilepsy taking antiepileptic drugs alongside caffeine or other methylxanthine derivatives.
    Expert opinion on drug metabolism & toxicology, 2014, Volume: 10, Issue:7

    Topics: Aminophylline; Animals; Anticonvulsants; Caffeine; Coffee; Drug Interactions; Epilepsy; Humans; Theophylline; Xanthines

2014
Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners.
    Exercise immunology review, 2014, Volume: 20

    Topics: Alkaloids; Anti-Inflammatory Agents; Antioxidants; Athletes; Beverages; Caffeine; Catechols; Diet; Dietary Supplements; Ephedrine; Exercise; Fatty Alcohols; Food; Food Analysis; Humans; Immune System; Immunologic Factors; Molecular Structure; Phytotherapy; Plants, Medicinal; Theophylline

2014
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
    Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21

    Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobromine; Theophylline; Uric Acid

2015
Drug therapy for treating post-dural puncture headache.
    The Cochrane database of systematic reviews, 2015, Jul-15, Issue:7

    Topics: Adrenocorticotropic Hormone; Adult; Amines; Analgesics; Blood Patch, Epidural; Caffeine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Male; Middle Aged; Pain Measurement; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture; Sumatriptan; Theophylline; Treatment Outcome

2015
The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.
    Respiratory medicine, 2016, Volume: 112

    Topics: Adolescent; Apnea; Asthma; Bronchodilator Agents; Caffeine; Child; Child, Preschool; Cough; Humans; Infant; Infant, Newborn; Infant, Premature; Phosphodiesterase Inhibitors; Theobromine; Theophylline; Xanthines

2016
Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.
    Molecules (Basel, Switzerland), 2016, Jul-27, Volume: 21, Issue:8

    Topics: Animals; Cacao; Caffeine; Humans; Molecular Structure; Phytochemicals; Secondary Metabolism; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines

2016
Doxapram Treatment for Apnea of Prematurity: A Systematic Review.
    Neonatology, 2017, Volume: 111, Issue:2

    Topics: Apnea; Caffeine; Doxapram; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Respiratory System Agents; Theophylline

2017
Health benefits of methylxanthines in neurodegenerative diseases.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:6

    Topics: Animals; Cacao; Caffeine; Coffee; Disease Models, Animal; Humans; Ilex paraguariensis; Meta-Analysis as Topic; Neurodegenerative Diseases; Plant Extracts; Theobromine; Theophylline; Xanthines

2017
Second-harmonic generation-based methods to detect and characterize ligand-induced RNA conformational changes.
    Methods (San Diego, Calif.), 2019, 09-01, Volume: 167

    Topics: Caffeine; Drug Discovery; High-Throughput Screening Assays; Humans; Ligands; Nucleic Acid Conformation; RNA; Theophylline

2019
Systematic analysis to assess the scientific validity of the international residue limits for caffeine and theophylline in horse-racing.
    The Veterinary record, 2019, 08-24, Volume: 185, Issue:8

    Topics: Animals; Caffeine; Doping in Sports; Drug Residues; Horses; Internationality; Reproducibility of Results; Theophylline

2019
Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit: A Systematic Overview of Meta-Analyses.
    Paediatric drugs, 2020, Volume: 22, Issue:4

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Randomized Controlled Trials as Topic; Theophylline; Treatment Outcome

2020
Methylxanthines and Neurodegenerative Diseases: An Update.
    Nutrients, 2021, Feb-28, Volume: 13, Issue:3

    Topics: Alzheimer Disease; Animals; Caffeine; Coffee; Humans; Multiple Sclerosis; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Theobromine; Theophylline; Xanthines

2021
Advances in Neonatal Acute Kidney Injury.
    Pediatrics, 2021, Volume: 148, Issue:5

    Topics: Acute Kidney Injury; Biomarkers; Caffeine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Premature; Kidney; Lipocalin-2; Multicenter Studies as Topic; Oxygen Consumption; Renal Replacement Therapy; Research; Risk Factors; Theophylline; Water-Electrolyte Balance

2021
Anesthetics and Cell-Cell Communication: Potential Ca
    International journal of molecular sciences, 2022, Aug-12, Volume: 23, Issue:16

    Topics: Anesthetics; Anesthetics, Inhalation; Caffeine; Calcium; Calmodulin; Cell Communication; Connexins; Gap Junctions; Halothane; Heptanol; Ion Channels; Isoflurane; Theophylline

2022
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
    International journal of molecular sciences, 2023, Aug-22, Volume: 24, Issue:17

    Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid

2023
Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants.
    The Cochrane database of systematic reviews, 2023, 10-04, Volume: 10

    Topics: Aminophylline; Apnea; Birth Weight; Bronchopulmonary Dysplasia; Caffeine; Hearing Loss; Humans; Infant, Extremely Premature; Infant, Newborn; Randomized Controlled Trials as Topic; Theophylline

2023

Trials

72 trial(s) available for caffeine and theophylline

ArticleYear
Caffeine or theophylline for neonatal apnoea?
    Archives of disease in childhood, 1992, Volume: 67, Issue:4 Spec No

    Topics: Apnea; Caffeine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Infant, Premature; Theophylline; Time Factors; Treatment Outcome

1992
A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:3

    Topics: Aged; Caffeine; Central Nervous System; Double-Blind Method; Humans; Middle Aged; Neuropsychological Tests; Psychomotor Performance; Reference Values; Theophylline

1991
The influence of caffeine on the steady-state pharmacokinetics of theophylline.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:3

    Topics: Administration, Oral; Adult; Caffeine; Drug Administration Schedule; Humans; Infusions, Intravenous; Male; Theophylline

1991
Caffeine consumption decreases the response to bronchoprovocation challenge with dry gas hyperventilation.
    Chest, 1991, Volume: 99, Issue:6

    Topics: Adolescent; Adult; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Caffeine; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Humidity; Hyperventilation; Male; Prospective Studies; Theophylline; Vital Capacity

1991
Lack of interaction between lomefloxacin and caffeine in normal volunteers.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:4

    Topics: 4-Quinolones; Adult; Anti-Infective Agents; Caffeine; Double-Blind Method; Drug Interactions; Fluoroquinolones; Half-Life; Humans; Male; Quinolones; Theophylline

1991
Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration.
    International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:4

    Topics: 4-Quinolones; Adult; Anti-Infective Agents; Caffeine; Fluoroquinolones; Humans; Male; Quinolones; Theophylline

1991
Dose-dependency of caffeine metabolism with repeated dosing.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:3

    Topics: Adult; Caffeine; Cardiovascular Diseases; Coffee; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Random Allocation; Risk Factors; Theobromine; Theophylline

1990
Theophylline disturbs sleep mainly in caffeine-sensitive persons.
    Pulmonary pharmacology, 1989, Volume: 2, Issue:3

    Topics: Caffeine; Double-Blind Method; Humans; Male; Sleep Wake Disorders; Surveys and Questionnaires; Theophylline

1989
Comparative evaluation of caffeine and theophylline for weaning premature infants from the ventilator.
    American journal of perinatology, 1989, Volume: 6, Issue:1

    Topics: Caffeine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Infant, Premature; Male; Random Allocation; Respiration; Stimulation, Chemical; Theophylline; Time Factors; Ventilator Weaning

1989
The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants.
    Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:5

    Topics: Administration, Oral; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant, Newborn; Infant, Premature; Male; Random Allocation; Theophylline

1989
Pharmacologic provocation and dexamethasone suppression test sensitivity.
    Neuropsychobiology, 1989, Volume: 22, Issue:1

    Topics: Caffeine; Depressive Disorder; Dexamethasone; Electroconvulsive Therapy; Humans; Hydrocortisone; Lorazepam; Prognosis; Randomized Controlled Trials as Topic; Theophylline

1989
4-quinolones inhibit biotransformation of caffeine.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:6

    Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline

1988
[Gyrase inhibitors can delay caffeine elimination].
    Deutsche medizinische Wochenschrift (1946), 1986, Sep-26, Volume: 111, Issue:39

    Topics: Caffeine; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Theophylline

1986
A controlled trial using ephedrine in the treatment of obesity.
    International journal of obesity, 1986, Volume: 10, Issue:2

    Topics: Caffeine; Clinical Trials as Topic; Drug Combinations; Ephedrine; Humans; Obesity; Theophylline

1986
Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant.
    The Journal of pediatrics, 1987, Volume: 110, Issue:4

    Topics: Apnea; Caffeine; Double-Blind Method; Heart Rate; Humans; Infant, Newborn; Infant, Premature, Diseases; Natriuresis; Random Allocation; Respiration; Theophylline

1987
The thermogenic properties of ephedrine/methylxanthine mixtures: human studies.
    International journal of obesity, 1986, Volume: 10, Issue:6

    Topics: Adult; Basal Metabolism; Body Temperature Regulation; Caffeine; Calorimetry; Disease Susceptibility; Drug Combinations; Energy Metabolism; Ephedrine; Fasting; Female; Food; Humans; Male; Obesity; Theophylline; Xanthines

1986
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:2

    Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromine; Theophylline

1985
Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:7

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Tachycardia; Theophylline

1985
[Clinical experiences with a vasoactive combination drug].
    Die Medizinische Welt, 1965, Jun-12, Volume: 24

    Topics: Caffeine; Cerebrovascular Disorders; Clinical Trials as Topic; Estradiol; Humans; Testosterone; Theophylline; Vasodilator Agents

1965
Caffeine and theophylline counteract diazepam effects in man.
    Medical biology, 1983, Volume: 61, Issue:6

    Topics: Adult; Caffeine; Clinical Trials as Topic; Cognition; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Antagonism; Female; Flicker Fusion; Humans; Male; Psychomotor Performance; Theophylline

1983
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children].
    Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16

    Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines

1984
Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:4

    Topics: Apnea; Bradycardia; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline

1995
Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.
    Pharmacogenetics, 1994, Volume: 4, Issue:3

    Topics: Adult; Aged; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Oxidoreductases; Phenotype; Reference Values; Retrospective Studies; Saliva; Theophylline

1994
Caffeine metabolism and epinephrine responses during exercise in users and nonusers.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:2

    Topics: Adult; Blood Glucose; Caffeine; Catecholamines; Epinephrine; Exercise; Fatty Acids, Nonesterified; Glycerol; Habituation, Psychophysiologic; Humans; Lactates; Lactic Acid; Male; Oxygen Consumption; Substance Withdrawal Syndrome; Theophylline

1993
Sympathomimetic effects of paraxanthine and caffeine in humans.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:6

    Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Epinephrine; Fatty Acids; Female; Heart Rate; Humans; Male; Middle Aged; Norepinephrine; Reference Values; Theophylline

1995
Methylxanthines increase renal calcium excretion in preterm infants.
    Biology of the neonate, 1995, Volume: 68, Issue:3

    Topics: Caffeine; Calcium; Humans; Infant, Newborn; Infant, Premature; Kidney; Theophylline

1995
Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance.
    Clinical pharmacology and therapeutics, 1996, Volume: 59, Issue:3

    Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Injections, Intravenous; Isotope Labeling; Male; Middle Aged; Oxidoreductases; Reference Values; Regression Analysis; Smoking; Theophylline

1996
Comparative effects of theophylline and caffeine on respiratory function of prematurely born infants.
    Early human development, 1998, Jan-09, Volume: 50, Issue:2

    Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Infant, Newborn; Infant, Premature, Diseases; Respiration; Respiratory Distress Syndrome, Newborn; Respiratory Function Tests; Theophylline; Time Factors

1998
Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants.
    European journal of pediatrics, 1998, Volume: 157, Issue:5

    Topics: Anemia; Apnea; Caffeine; Erythropoietin; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Theophylline

1998
Psychomotor performance: investigating the dose-response relationship for caffeine and theophylline in elderly volunteers.
    European journal of clinical pharmacology, 1998, Volume: 54, Issue:4

    Topics: Aged; Aged, 80 and over; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychomotor Performance; Theophylline

1998
Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance.
    European journal of clinical pharmacology, 1999, Volume: 54, Issue:12

    Topics: Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Interactions; Fluvoxamine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Theophylline

1999
The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained?
    Pharmacogenetics, 1999, Volume: 9, Issue:3

    Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Humans; Male; Saliva; Specimen Handling; Theophylline

1999
Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:9

    Topics: Aged; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Estradiol; Estrogen Replacement Therapy; Female; Humans; Menopause; Middle Aged; Theophylline

1999
Omeprazole weakly inhibits CYP1A2 activity in man.
    International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:11

    Topics: Adult; Binding, Competitive; Biomarkers; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Omeprazole; Single-Blind Method; Theophylline

1999
Effect of caffeine on clozapine pharmacokinetics in healthy volunteers.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:1

    Topics: Adult; Antipsychotic Agents; Area Under Curve; Biotransformation; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Clozapine; Cross-Over Studies; Humans; Male; Theophylline

2000
Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Data Interpretation, Statistical; Female; Humans; Male; Metabolic Clearance Rate; Phenotype; Polymorphism, Genetic; Sex Factors; Theophylline

2000
Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women.
    International journal of clinical pharmacology and therapeutics, 2000, Volume: 38, Issue:5

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Menstrual Cycle; Middle Aged; Pilot Projects; Saliva; Theophylline

2000
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:2

    Topics: Administration, Oral; Caffeine; Child; Child, Preschool; Cytochrome P-450 CYP1A2; Female; Half-Life; Humans; Infant; Kwashiorkor; Malaria; Male; Metabolic Clearance Rate; Nigeria; Theophylline

2000
The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:2

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Caffeine; Child; Cytochrome P-450 CYP1A2; Female; Humans; Malaria, Falciparum; Male; Metabolic Clearance Rate; Nigeria; Saliva; Theophylline

2000
Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5

    Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Blood Glucose; Caffeine; Central Nervous System Stimulants; Citric Acid; Cyclic AMP; Energy Metabolism; Epinephrine; Fatty Acids, Nonesterified; Glucose-6-Phosphatase; Glycerol; Glycogen; Humans; Lactic Acid; Male; Muscle, Skeletal; Norepinephrine; Oxygen Consumption; Physical Endurance; Theophylline; Vasodilator Agents; Xanthines

2000
An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:3

    Topics: Adult; Anthropometry; Blood Pressure; Caffeine; Dietary Supplements; Double-Blind Method; Drug Combinations; Drugs, Chinese Herbal; Female; Heart Rate; Humans; Male; Middle Aged; Obesity; Theobromine; Theophylline; Triglycerides; Weight Loss

2001
In vivo effect of clarithromycin on multiple cytochrome P450s.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Humans; Male; Theophylline; Tolbutamide

2001
Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2001, Volume: 14, Issue:3

    Topics: Caffeine; Double-Blind Method; Female; Gastric Emptying; Humans; Ilex paraguariensis; Male; Obesity; Phytotherapy; Plant Extracts; Plant Leaves; Seeds; Stomach; Theobromine; Theophylline; Time Factors; Turnera; Ultrasonography; Weight Loss

2001
Drug interactions with clinafloxacin.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9

    Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin

2001
Urinary biomarkers for assessing dietary exposure to caffeine.
    Food additives and contaminants, 2001, Volume: 18, Issue:12

    Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines

2001
Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:6

    Topics: Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Emotions; Ephedra; Ephedra sinica; Ephedrine; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Heart Rate; Humans; Male; Phenylpropanolamine; Pilot Projects; Reference Values; Theobromine; Theophylline

2002
Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 94, Issue:4

    Topics: Adult; Bicycling; Caffeine; Double-Blind Method; Drug Administration Schedule; Humans; Male; Osmolar Concentration; Physical Endurance; Theophylline

2003
Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers.
    European journal of clinical pharmacology, 2003, Volume: 59, Issue:3

    Topics: Adult; Bronchodilator Agents; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Female; Humans; Isoflavones; Male; Single-Blind Method; Theophylline

2003
Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio.
    Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:3

    Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Theophylline

2003
Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
    The American journal of clinical nutrition, 2004, Volume: 79, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Central Nervous System Stimulants; Energy Metabolism; Humans; Lipid Metabolism; Lipolysis; Male; Oxidation-Reduction; Propranolol; Theophylline

2004
Salivary caffeine metabolic ratio in alcohol-dependent subjects.
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:2

    Topics: Alcoholism; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Humans; Liver Diseases; Liver Function Tests; Male; Saliva; Smoking; Theophylline

2004
Serum metabolite/caffeine ratios as a test for liver function.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:4

    Topics: Adult; Caffeine; Female; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Theobromine; Theophylline

2004
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
    Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Biological Availability; Caffeine; Central Nervous System Stimulants; Drug Combinations; Drug Interactions; Half-Life; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Narcotics; Population; Theobromine; Theophylline

2005
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:4

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline

2005
A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:1

    Topics: Administration, Oral; Adult; Affect; Attention; Caffeine; Capsules; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memory; Psychotropic Drugs; Reference Values; Theobromine; Theophylline

2007
Liver disease selectively modulates cytochrome P450--mediated metabolism.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline

2006
Urinary excretion of dietary contaminants in horses.
    Equine veterinary journal. Supplement, 2006, Issue:36

    Topics: Animals; Atropine; Bufotenin; Caffeine; Cross-Over Studies; Doping in Sports; Dose-Response Relationship, Drug; Food Contamination; Horses; Morphine; N,N-Dimethyltryptamine; Physical Conditioning, Animal; Scopolamine; Theobromine; Theophylline

2006
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline

2008
Caffeine versus theophylline for apnea of prematurity: a randomised controlled trial.
    Journal of paediatrics and child health, 2009, Volume: 45, Issue:10

    Topics: Apnea; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Drug Therapy, Combination; Greece; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Secondary Prevention; Theophylline

2009
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:10

    Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stability; Humans; Least-Squares Analysis; Male; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline; Young Adult

2010
Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:9

    Topics: Adult; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Clinical Enzyme Tests; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Reference Values; Saliva; Theophylline; Young Adult

2011
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:6

    Topics: Adolescent; Adult; Caffeine; Clozapine; Computer Simulation; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Humans; Liver; Male; Middle Aged; Models, Biological; Serotonin 5-HT2 Receptor Agonists; Smoking; Theophylline; Young Adult

2012
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.
    Drug metabolism letters, 2012, Jun-01, Volume: 6, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult

2012
Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects.
    Clinical pharmacology and therapeutics, 2013, Volume: 93, Issue:3

    Topics: Adult; Bacillus; Blood Pressure; Caffeine; Cross-Over Studies; Dietary Supplements; Drug Contamination; Electrocardiography; Heart Rate; Humans; Male; Theophylline

2013
Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial.
    Nutrition journal, 2013, Apr-08, Volume: 12

    Topics: Adolescent; Adult; Biomarkers; Blood Pressure; Cacao; Caffeine; Candy; Catechin; Double-Blind Method; Endothelium; Energy Intake; Feasibility Studies; Female; Healthy Volunteers; Humans; Patient Compliance; Pilot Projects; Polyphenols; Pregnancy; Theobromine; Theophylline; Young Adult

2013
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult

2014
The effect of a single dose of multivitamin and mineral combinations with and without guaraná on functional brain activity during a continuous performance task.
    Nutritional neuroscience, 2017, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Attention; Brain; Caffeine; Calcium, Dietary; Cognition; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Evoked Potentials, Visual; Follow-Up Studies; Functional Neuroimaging; Humans; Magnesium; Neurons; Performance-Enhancing Substances; Theobromine; Theophylline; Vitamins; Young Adult; Zinc

2017
The Effect of Caffeine Ingestion during Evening Exercise on Subsequent Sleep Quality in Females.
    International journal of sports medicine, 2015, Volume: 36, Issue:6

    Topics: Adult; Caffeine; Contraceptives, Oral; Cross-Over Studies; Double-Blind Method; Exercise; Exercise Test; Female; Humans; Sleep; Theobromine; Theophylline; Young Adult

2015
Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites.
    Journal of clinical pharmacology, 2016, Volume: 56, Issue:5

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Pregnancy; Pregnancy Trimesters; Theobromine; Theophylline; Young Adult

2016
Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Animals, Newborn; Caffeine; Drug Monitoring; Glucose; Healthy Volunteers; Hydrogel, Polyethylene Glycol Dimethacrylate; Microinjections; Pharmaceutical Preparations; Rats; Reproducibility of Results; Sus scrofa; Theophylline

2015
Establishing population distribution of drug-metabolizing enzyme activities for the use of salivary caffeine as a dynamic liver function marker in a Singaporean Chinese population.
    Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:3

    Topics: Adult; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Liver; Male; Middle Aged; Saliva; Theophylline; Young Adult

2016
A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects.
    Clinical pharmacology in drug development, 2021, Volume: 10, Issue:11

    Topics: Adult; Anticonvulsants; Caffeine; Cannabidiol; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Humans; Male; Theophylline; Young Adult

2021

Other Studies

1502 other study(ies) available for caffeine and theophylline

ArticleYear
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
    Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16

    Topics: Acute Kidney Injury; Adenosine; Animals; Cations, Monovalent; Diuretics; Male; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sodium; Structure-Activity Relationship; Xanthines

1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
    Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Guinea Pigs; Humans; Molecular Conformation; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Xanthines

1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.
    Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Corpus Striatum; Guinea Pigs; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Structure-Activity Relationship; Xanthines

1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Diuretics; Indicators and Reagents; Kidney; Kidney Function Tests; Kinetics; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1991
Imidazodiazepinediones: a new class of adenosine receptor antagonists.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Azepines; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Imidazoles; In Vitro Techniques; Molecular Conformation; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Structure-Activity Relationship

1990
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines

1989
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:10

    Topics: Animals; Brain; Cell Membrane; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1989
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:4

    Topics: Adenosine; Animals; Cerebral Cortex; In Vitro Techniques; Rats; Receptors, Cell Surface; Receptors, Purinergic; Solubility; Structure-Activity Relationship

1985
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Caffeine; Cell Membrane; Cerebral Cortex; Indicators and Reagents; Mass Spectrometry; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthines

1986
Mesoionic xanthine analogues: antagonists of adenosine receptors.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:10

    Topics: Adenosine; Animals; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Rats; Receptors, Cell Surface; Receptors, Purinergic; Spectrophotometry, Infrared; Structure-Activity Relationship; Xanthines

1984
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
    Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines

1994
8-Azaxanthine derivatives as antagonists of adenosine receptors.
    Journal of medicinal chemistry, 1994, Sep-02, Volume: 37, Issue:18

    Topics: Animals; Brain; Cattle; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines

1994
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.
    Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10

    Topics: Animals; Brain; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Xanthines

1994
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.
    Journal of medicinal chemistry, 1993, Aug-20, Volume: 36, Issue:17

    Topics: Adenosine; Amnesia; Animals; Avoidance Learning; Diuretics; Male; Mice; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptors, Purinergic; Scopolamine; Structure-Activity Relationship; Xanthines

1993
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
    Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18

    Topics: Acylation; Alkylation; Animals; Brain; Caffeine; Cell Membrane; Cyclization; Molecular Structure; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Trifluoroacetic Acid; Xanthines

1993
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Adenosine; Animals; Binding, Competitive; Brain; Caffeine; Molecular Structure; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theobromine; Xanthines

1997
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.
    Journal of natural products, 1998, Volume: 61, Issue:2

    Topics: Acridines; Alkaloids; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Artemia; Bacteria; Cladosporium; Drug Screening Assays, Antitumor; HeLa Cells; Humans; In Vitro Techniques; Insecticides; Microbial Sensitivity Tests; Neostriatum; Porifera; Rats; Receptors, GABA-A; Receptors, Purinergic P1

1998
Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues.
    Journal of medicinal chemistry, 1999, Jul-15, Volume: 42, Issue:14

    Topics: Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Cyclic ADP-Ribose; Drug Evaluation, Preclinical; In Vitro Techniques; Ovum; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Structure-Activity Relationship; Xanthines

1999
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
    Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25

    Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats

1999
Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea.
    Journal of natural products, 2000, Volume: 63, Issue:3

    Topics: Chromones; Flavonoids; Luteolin; Naphthalenes; Plants, Medicinal; Receptors, Purinergic P1; Spectrum Analysis

2000
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
    Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11

    Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines

2002
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.
    Journal of medicinal chemistry, 2002, Aug-01, Volume: 45, Issue:16

    Topics: 3T3 Cells; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Electrophoresis, Capillary; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; In Vitro Techniques; Membranes; Mice; PC12 Cells; Purinergic P1 Receptor Antagonists; Purines; Purinones; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Solubility; Stereoisomerism; Structure-Activity Relationship; Water

2002
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Estradiol; Female; Humans; In Vitro Techniques; Male; Metribolone; Pregnenediones; Prostate; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Thermodynamics; Uterus

2005
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
    Chemistry & biology, 2005, Volume: 12, Issue:9

    Topics: Chitinases; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Protein Binding; Xanthines

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
QSAR study on permeability of hydrophobic compounds with artificial membranes.
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship

2007
Impaired mutagenic activities of MPDP(+) (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP(+) (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines.
    Bioorganic & medicinal chemistry, 2007, Aug-01, Volume: 15, Issue:15

    Topics: 1-Methyl-4-phenylpyridinium; Caffeine; Calorimetry; Drug Interactions; Models, Molecular; Molecular Structure; Mutagens; Pentoxifylline; Pyridinium Compounds; Spectrophotometry, Atomic; Vibrio

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies.
    Purinergic signalling, 2006, Volume: 2, Issue:3

    Topics:

2006
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
    Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13

    Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Adenosine A1 Receptor Antagonists; Animals; Drug Design; Humans; Molecular Structure; Rats; Receptor, Adenosine A1; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2010
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:8

    Topics: Adenosine A2 Receptor Antagonists; Amino Acid Sequence; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Receptor, Adenosine A2B; Reproducibility of Results; Sequence Homology, Amino Acid

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.
    Journal of medicinal chemistry, 2010, Aug-26, Volume: 53, Issue:16

    Topics: Action Potentials; Animals; Behavior, Animal; Cells, Cultured; Convulsants; Crystallography, X-Ray; Excitatory Postsynaptic Potentials; Guanine; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neurons; Palau; Patch-Clamp Techniques; Porifera; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Synaptic Transmission

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Importance of physicochemical properties for the design of new pesticides.
    Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7

    Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Biophysical mapping of the adenosine A2A receptor.
    Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13

    Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Drug Design; Ligands; Models, Molecular; Mutation; Pyrimidines; Receptor, Adenosine A2A; Small Molecule Libraries; Triazines; Triazoles; Xanthines

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines--analysis with mathematical models.
    Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11

    Topics: Aminacrine; Animals; Caffeine; Cattle; DNA; Drug Antagonism; Epithelial Cells; Intercalating Agents; Kidney; Kinetics; Models, Chemical; Mutagens; Nitrogen Mustard Compounds; Pentoxifylline; Salmonella typhimurium; Theophylline; Thermodynamics

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
    Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines

2013
Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
    European journal of medicinal chemistry, 2014, Sep-12, Volume: 84

    Topics: Algorithms; Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quantitative Structure-Activity Relationship

2014
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats

2015
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
    Journal of medicinal chemistry, 2015, Feb-26, Volume: 58, Issue:4

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoenzymes; Mice; Mice, Knockout; Models, Molecular; Molecular Structure; Retinal Dehydrogenase; Structure-Activity Relationship

2015
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
    European journal of medicinal chemistry, 2015, Apr-13, Volume: 94

    Topics: Acetylcholinesterase; Animals; Benzofurans; Blood-Brain Barrier; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Drug Stability; Microsomes, Liver; Molecular Docking Simulation; Permeability; Rats; Structure-Activity Relationship; Torpedo

2015
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.
    Journal of medicinal chemistry, 2016, Mar-10, Volume: 59, Issue:5

    Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Pyrimidinones; Receptor, Adenosine A2B; Structure-Activity Relationship

2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine

2016
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
    Chemical biology & drug design, 2016, Volume: 88, Issue:6

    Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain

2016
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Jan-27, Volume: 126

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats

2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine

2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
    Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary

2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2017, 03-15, Volume: 25, Issue:6

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones

2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats

2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2017, 06-15, Volume: 25, Issue:12

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine

2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22

    Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship

2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship

2017
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
    Bioorganic & medicinal chemistry, 2018, 03-01, Volume: 26, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship

2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles

2018
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
    Bioorganic & medicinal chemistry letters, 2018, 06-15, Volume: 28, Issue:11

    Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship

2018
Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.
    MedChemComm, 2018, Jun-01, Volume: 9, Issue:6

    Topics:

2018
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2018, 12-15, Volume: 26, Issue:23-24

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship

2018
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
    Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine

2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Sep-15, Volume: 178

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship

2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Oct-15, Volume: 180

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates

2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship

2019
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
    European journal of medicinal chemistry, 2020, Jan-01, Volume: 185

    Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2020
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphenyl Compounds; Butyrylcholinesterase; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuroprotective Agents; Picrates; Rats; Structure-Activity Relationship; Sulfonic Acids; Xanthones

2021
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
    Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8

    Topics: Binding Sites; Catalytic Domain; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Esterases; Humans; Molecular Dynamics Simulation; Small Molecule Libraries; Wnt Signaling Pathway

2021
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
    Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49

    Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines

2021
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors

2021
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments.
    ACS medicinal chemistry letters, 2022, Jul-14, Volume: 13, Issue:7

    Topics:

2022
[Level of nicotinamide coenzymes in the myocardium of rats during the effects of methylxanthines (theophylline, theobromine, caffeine) and catecholamines].
    Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 79, Issue:4

    Topics: Animals; Caffeine; Epinephrine; Female; Heart; Isoproterenol; Male; Myocardium; NAD; NADP; Norepinephrine; Rats; Stimulation, Chemical; Theobromine; Theophylline

1975
Practolol, caffeine and calcium in the regulation of mechanical activity of the cardiac ventricle in Myxine glutinosa (L.).
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1975, Oct-01, Volume: 52, Issue:1

    Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Fishes; Hagfishes; Heart Ventricles; Hydroxydopamines; Myocardial Contraction; Phenoxybenzamine; Phentolamine; Practolol; Propranolol; Reserpine; Theophylline; Ventricular Function

1975
Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists.
    Life sciences, 1975, Oct-10, Volume: 17, Issue:7

    Topics: Action Potentials; Adenine Nucleotides; Adenosine; Animals; Blood Pressure; Caffeine; Cerebral Cortex; Dose-Response Relationship, Drug; Hexobendine; Male; Neurotransmitter Agents; Papaverine; Rats; Receptors, Drug; Structure-Activity Relationship; Theophylline

1975
Cylic nucleotide phosphodiesterase in silkworm. Characterization of cyclic GMP phosphodiesterase.
    Biochimica et biophysica acta, 1975, Dec-18, Volume: 410, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bombyx; Caffeine; Chromatography, Gel; Cyclic AMP; Cyclic GMP; Cyclic IMP; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Molecular Weight; Nucleotides; Phosphoric Diester Hydrolases; Theophylline

1975
Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas.
    Journal of the National Cancer Institute, 1976, Volume: 56, Issue:1

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Calcium; Cobalt; Cyclic AMP; Cyclic GMP; Depression, Chemical; Edetic Acid; Egtazic Acid; Hydrogen-Ion Concentration; Magnesium; Manganese; Neoplasm Metastasis; Nickel; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Theophylline; Zinc

1976
Letter: Caffeine, theophylline and human sperm motility.
    Fertility and sterility, 1976, Volume: 27, Issue:7

    Topics: Caffeine; Cells, Cultured; Humans; Hydrogen-Ion Concentration; Male; Sperm Motility; Theophylline

1976
Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat.
    Pharmacology, 1976, Volume: 14, Issue:1

    Topics: Amobarbital; Amphetamines; Anesthetics; Animals; Benzamides; Bucladesine; Caffeine; Central Nervous System Stimulants; Doxapram; Male; Pentylenetetrazole; Picrotoxin; Rats; Strychnine; Theophylline

1976
Potentiation of dopaminergic transmission by phosphodiesterase inhibitors and cyclic nucleotides.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:12

    Topics: Action Potentials; Animals; Bucladesine; Caffeine; Cyclic AMP; Dopamine; In Vitro Techniques; Mollusca; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Prostaglandins E; Synaptic Transmission; Theophylline

1976
Cyclic nucleotide phosphodiesterases of Hyalophora cecropia silkmoth fat body.
    Biochimica et biophysica acta, 1977, Mar-15, Volume: 481, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Bombyx; Caffeine; Chromatography, Gel; Cyclic AMP; Cyclic GMP; Edetic Acid; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Larva; Manganese; Phosphoric Diester Hydrolases; Theophylline

1977
Caffeine-phenacetin interaction in the rat: effects on absorption, metabolism and locomotor activity.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:4

    Topics: Animals; Caffeine; Dextroamphetamine; Drug Interactions; Female; Intestinal Absorption; Motor Activity; Phenacetin; Rats; Theobromine; Theophylline; Time Factors

1977
Interpretation of dissolution rate data from in vitro testing of compressed tablets.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:8

    Topics: Aspirin; Caffeine; Chemistry, Pharmaceutical; Hardness; Kinetics; Models, Chemical; Solubility; Surface Properties; Tablets; Theophylline; Time Factors

1977
Association of increased pHi with calcium ion release in skeletal muscle.
    The American journal of physiology, 1978, Volume: 234, Issue:3

    Topics: Animals; Anura; Caffeine; Calcium; Dantrolene; Dimethadione; Extracellular Space; Hydrogen-Ion Concentration; Insulin; Muscles; Procaine; Quinine; Rana pipiens; Sarcoplasmic Reticulum; Theophylline

1978
Clear, defined medium for the sporulation of Clostridium perfringens.
    Applied and environmental microbiology, 1978, Volume: 35, Issue:2

    Topics: Caffeine; Clostridium perfringens; Culture Media; Hydrogen-Ion Concentration; Spores, Bacterial; Theophylline

1978
Influence of methyl xanthine treatment on calcitonin effect.
    Aktuelle Gerontologie, 1978, Volume: 8, Issue:2

    Topics: Androgens; Animals; Caffeine; Calcitonin; Calcium; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Time Factors; Xanthines

1978
Intravenous cimetidine and methylxanthines stimulated gastric acid secretion in man.
    Il Farmaco; edizione pratica, 1979, Volume: 34, Issue:11

    Topics: Adult; Caffeine; Cimetidine; Female; Gastric Juice; Guanidines; Histamine H2 Antagonists; Humans; Male; Stimulation, Chemical; Theophylline

1979
Enhancement effect of methylxanthines on the intestinal absorption of poorly absorbable dyes from the rat small intestine.
    Biochemical pharmacology, 1979, Oct-01, Volume: 28, Issue:19

    Topics: Animals; Bromphenol Blue; Caffeine; Coloring Agents; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Phenolsulfonphthalein; Rats; Salicylates; Theophylline; Xanthines

1979
Chromatography of xanthines on ion-exchange resins.
    Journal of chromatography, 1979, Nov-28, Volume: 180, Issue:1

    Topics: Caffeine; Cation Exchange Resins; Chromatography, Ion Exchange; Coffee; Humans; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Theophylline; Xanthines

1979
Cyclic nucleotide phosphodiesterase activity of human normal and carcinomatous lung tissue.
    Lancet (London, England), 1976, Dec-04, Volume: 2, Issue:7997

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Caffeine; Carcinoma, Squamous Cell; Cyclic AMP; Cyclic GMP; Female; Humans; Lung; Lung Neoplasms; Middle Aged; Phosphoric Diester Hydrolases; Theophylline

1976
Biotransformation of theophylline to caffeine in premature newborn.
    Lancet (London, England), 1978, Dec-02, Volume: 2, Issue:8101

    Topics: Administration, Oral; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline

1978
Methylation of theophylline to caffeine in premature infants.
    Lancet (London, England), 1979, Apr-14, Volume: 1, Issue:8120

    Topics: Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Methylation; Theophylline; Xanthines

1979
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles

1979
Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies.
    Biochemical pharmacology, 1979, Mar-15, Volume: 28, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Protein Denaturation; Theophylline; Time Factors; Xanthines

1979
The inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain.
    Histochemistry, 1979, Jun-18, Volume: 61, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Aminophylline; Animals; Caffeine; Cerebral Cortex; Female; Histocytochemistry; Male; Rats; Synaptosomes; Theophylline; Xanthines

1979
Effect of cAMP on acrosome reaction and fertilization.
    Biology of reproduction, 1979, Volume: 21, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Bucladesine; Caffeine; Cricetinae; Cyclic AMP; Female; Fertilization; Guinea Pigs; Imidazoles; Male; Ovum; Phosphodiesterase Inhibitors; Sperm Motility; Spermatozoa; Theophylline

1979
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: relationship of enzyme activity to cyclic AMP concentrations.
    Journal of cellular physiology, 1979, Volume: 100, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Induction; HeLa Cells; Humans; Hydrocortisone; Idoxuridine; Theophylline; Xanthines

1979
Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase.
    International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cell Survival; Jejunum; Male; Mice; Radiation-Protective Agents; Reserpine; Theophylline

1979
Inhibition of RNA-dependent DNA polymerase activity of oncornaviruses by caffeine.
    Biochemical and biophysical research communications, 1979, Nov-14, Volume: 91, Issue:1

    Topics: Aminophylline; Avian Leukosis Virus; Avian Myeloblastosis Virus; Caffeine; Kinetics; Reverse Transcriptase Inhibitors; Templates, Genetic; Theophylline

1979
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex.
    Canadian journal of physiology and pharmacology, 1979, Volume: 57, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Brain; Caffeine; Cerebral Cortex; Male; Neural Inhibition; Neurons; Rats; Synapses; Synaptic Transmission; Theophylline

1979
Calcium and cyclic nucleotide interaction in secretion of amylase from rat pancreas in vitro.
    The Journal of physiology, 1979, Volume: 296

    Topics: Amylases; Animals; Bucladesine; Caffeine; Calcimycin; Calcium; Cholecystokinin; Cholera Toxin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Pancreas; Rats; Secretory Rate; Theophylline

1979
The change of erythrocyte shape following action of different substances altering mg++-dependent ATPase activity (actomyosin-like protein).
    Blut, 1977, Volume: 34, Issue:2

    Topics: Adenosine Triphosphatases; Aspartic Acid; Atropine; Barbiturates; Caffeine; Dose-Response Relationship, Drug; Ephedrine; Erythrocytes; Glutamates; Humans; Magnesium; Physostigmine; Theophylline

1977
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline

1977
Human placental cAMP phosphodiesterase activity kinetic properties and sensitivity to some drugs and hormones.
    FEBS letters, 1975, Apr-01, Volume: 52, Issue:2

    Topics: Caffeine; Cyclic AMP; Epinephrine; Estradiol; Female; Flufenamic Acid; Hormones; Humans; Imidazoles; Indomethacin; Insulin; Kinetics; Magnesium; Norepinephrine; Pharmacology; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Progesterone; Prostaglandins; Theophylline

1975
Methylxanthine induced small intestinal secretion.
    The Johns Hopkins medical journal, 1975, Volume: 136, Issue:6

    Topics: Animals; Animals, Newborn; Caffeine; Coffee; Cyclic AMP; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Jejunum; Male; Phosphodiesterase Inhibitors; Rats; Stimulation, Chemical; Theophylline; Time Factors

1975
Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.
    Life sciences, 1975, Jun-15, Volume: 16, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Male; Morphine; Naloxone; Phosphodiesterase Inhibitors; Prostaglandins; Rats; Structure-Activity Relationship; Substance Withdrawal Syndrome; Theophylline; Time Factors; Xanthines

1975
Enhancement of SV40 transformation by treatment of C3H2K cells with UV light and caffeine. I. Combined effect of UV light and caffeine.
    Virology, 1975, Volume: 66, Issue:2

    Topics: Animals; Bucladesine; Caffeine; Cell Line; Cell Transformation, Neoplastic; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Kidney; Mice; Mice, Inbred Strains; Radiation Effects; Simian virus 40; Theophylline; Ultraviolet Rays

1975
Bronchodilator drug efficacy via cyclic AMP.
    Thorax, 1975, Volume: 30, Issue:2

    Topics: Animals; Bronchodilator Agents; Caffeine; Cyclic AMP; Ephedrine; Epinephrine; Isoproterenol; Lung; Norepinephrine; Phentolamine; Propranolol; Rats; Theophylline

1975
Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature.
    Biochemical and biophysical research communications, 1975, Sep-16, Volume: 66, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Aminophylline; Animals; Caffeine; Cell Nucleus; Cyclic AMP; Cytosol; Dexamethasone; Kinetics; Liver; Male; Rats; Receptors, Cell Surface; Temperature; Theophylline

1975
Actions of various methylxanthines and papaverine on the synthesis of corticosterone in vitro.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:8

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Bucladesine; Caffeine; Corticosterone; Depression, Chemical; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Theobromine; Theophylline; Time Factors

1975
Calcium distribution in islets of Langerhans: a study of calcium concentrations and of calcium accumulation in B cell organelles.
    Journal of cell science, 1975, Volume: 19, Issue:2

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biological Transport, Active; Bucladesine; Caffeine; Calcium; Cell Nucleus; Cyclic AMP; Cyclic GMP; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Female; Islets of Langerhans; Mitochondria; Rats; Subcellular Fractions; Theophylline; Xanthines

1975
Circadian periodicity a neurospora: alteration by inhibitors of cyclic AMP phosphodiesterase.
    Science (New York, N.Y.), 1975, Nov-21, Volume: 190, Issue:4216

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Circadian Rhythm; Cyclic AMP; Dose-Response Relationship, Drug; Mutation; Neurospora crassa; Phosphodiesterase Inhibitors; Theophylline

1975
Comparative studies on sporulation-promotive actions on cyclic AMP, theophylline and caffeine in Saccharomyces cerevisiae.
    Archives of microbiology, 1975, Oct-27, Volume: 105, Issue:2

    Topics: Acetates; Caffeine; Cyclic AMP; DNA; Fungal Proteins; Glucose; RNA; Saccharomyces cerevisiae; Spores, Fungal; Theophylline

1975
Induction of thymidylate synthetase activity in Tetrahymena by cyclic guanosine monophosphate.
    Biochemical and biophysical research communications, 1975, Dec-15, Volume: 67, Issue:4

    Topics: Animals; Bucladesine; Caffeine; Cell Division; Culture Media; Cyclic GMP; Enzyme Induction; Methyltransferases; Tetrahymena pyriformis; Theophylline; Thymidylate Synthase

1975
Effect of methylxanthines on alloxan inhibition of insulin release.
    Diabetologia, 1975, Volume: 11, Issue:6

    Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Xanthines

1975
Specific thin-layer chromatographic method for the determination of theophylline in plasma in the presence of some other drugs.
    Journal of chromatography, 1975, Dec-24, Volume: 115, Issue:2

    Topics: Absorption; Caffeine; Chromatography, Thin Layer; Densitometry; Gels; Microchemistry; Silicon Dioxide; Spectrum Analysis; Theophylline

1975
Inhibition of 5'-nucleotidase in rat brain by methylxanthines.
    Journal of neurochemistry, 1975, Volume: 25, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Caffeine; Nucleotidases; Rats; Theobromine; Theophylline; Xanthines

1975
Studies on myoinositol. Effects of caffeine and theophylline on incorporation of myoinositol into phosphatidylinositol in rat liver homogenate.
    Journal of nutritional science and vitaminology, 1975, Volume: 21, Issue:4

    Topics: Animals; Caffeine; Cyclic AMP; In Vitro Techniques; Inositol; Liver; Phosphatidylinositols; Rats; Stimulation, Chemical; Theophylline

1975
Cyclic AMP phosphodiesterase activity in fetal and adult muscle of the rhesus monkey.
    Developmental biology, 1976, Volume: 48, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Female; Kinetics; Macaca; Macaca mulatta; Male; Muscles; Phosphoric Diester Hydrolases; Pregnancy; Theophylline; Xanthines

1976
[The stimulating effect of cyclic AMP, glucagon and insulin on guanidine acetate-N-methyltransferase activity in rat liver and pancreas].
    Biokhimiia (Moscow, Russia), 1976, Volume: 41, Issue:2

    Topics: Animals; Bucladesine; Caffeine; Cyclic AMP; Cycloheximide; Glucagon; Insulin; Liver; Magnesium; Methyltransferases; Oligomycins; Pancreas; Rats; Theophylline

1976
Ammonium sulfate activation of phosphodiesterase in homogenates of larvae of the european corn borer.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 152, Issue:2

    Topics: Ammonium Sulfate; Animals; Astacoidea; Caffeine; Cattle; Enzyme Activation; Kidney; Larva; Lepidoptera; Liver; Moths; Osmolar Concentration; Phosphoric Diester Hydrolases; Rats; Sodium Chloride; Species Specificity; Theophylline

1976
Poly(adenosine diphosphate ribose) polymerase activity and nicotinamide adenine dinucleotide in differentiating cardiac muscle.
    The Biochemical journal, 1976, Feb-15, Volume: 154, Issue:2

    Topics: Adenosine Triphosphate; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Nucleus; Dactinomycin; DNA; DNA Nucleotidyltransferases; Heart; Isoproterenol; Myocardium; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Proteins; Rats; Theophylline; Thymidine; Xanthines

1976
A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens.
    Immunochemistry, 1976, Volume: 13, Issue:7

    Topics: Blood Platelets; Caffeine; Cell Membrane; Cyclic AMP; Cytotoxicity Tests, Immunologic; Edetic Acid; Histocompatibility Antigens; HLA Antigens; Humans; Methods; Prostaglandins E; Solubility; Theophylline

1976
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys.
    Prostaglandins, 1976, Volume: 11, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Drug Synergism; Epinephrine; Female; Haplorhini; Indomethacin; Macaca mulatta; Myometrium; Phosphoric Diester Hydrolases; Pregnancy; Prostaglandins E; Theophylline; Uterine Contraction; Uterus

1976
Caffeine, cyclic AMP and postreplication repair of mammalian cell DNA.
    Biochimica et biophysica acta, 1976, Oct-04, Volume: 447, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Caffeine; Cell Line; Cyclic AMP; DNA Repair; DNA Replication; Drug Resistance; Theophylline

1976
Partial purification of adenosine 3',5'-cyclic monophosphate phosphodiesterases from rat pancreas in the presence of excess protease inhibitors.
    Archives of biochemistry and biophysics, 1976, Volume: 176, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cyclic GMP; Cyclic IMP; Isoenzymes; Kinetics; Male; Pancreas; Phosphoric Diester Hydrolases; Protease Inhibitors; Rats; Theophylline

1976
Action of insulin and cell calcium: effect of ionophore A23187.
    The Journal of membrane biology, 1976, Nov-29, Volume: 29, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Bucladesine; Caffeine; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Insulin; Membrane Potentials; Methylglucosides; Muscle Contraction; Muscles; Rats; Theophylline

1976
Timing of mitosis in Physarum polycephalum: effects of agents affecting cyclic AMP concentrations.
    Experientia, 1977, Jan-15, Volume: 33, Issue:1

    Topics: Bucladesine; Caffeine; Culture Media; Cyclic AMP; Mitosis; Myxomycetes; Physarum; Theophylline; Time Factors

1977
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation.
    Prostaglandins, 1977, Volume: 13, Issue:1

    Topics: Angiotensin II; Animals; Caffeine; Drug Synergism; Female; Guinea Pigs; Ileum; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins E; Rats; Theophylline; Uterus; Xanthines

1977
Characterization of sea urchin sperm adenylate cyclase.
    Biology of reproduction, 1977, Volume: 16, Issue:3

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Chromatography, Gel; Creatine Kinase; Cyclic AMP; Detergents; Hot Temperature; Kinetics; Magnesium; Male; Manganese; Phosphocreatine; Phosphoric Monoester Hydrolases; Sea Urchins; Solubility; Spermatozoa; Theophylline; Xanthines

1977
Interaction of cyclic AMP and alloxan on insulin secretion in isolated rat islets perifused in vitro.
    Endocrinology, 1977, Volume: 100, Issue:5

    Topics: Alloxan; Animals; Bucladesine; Caffeine; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Theophylline; Tolbutamide

1977
Adenosine-sensitive adenylate cyclase in rat striatal homogenates.
    FEBS letters, 1977, Mar-15, Volume: 75, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Adenylyl Cyclases; Animals; Caffeine; Corpus Striatum; Cyclic AMP; Kinetics; Male; Rats; Structure-Activity Relationship; Theophylline; Xanthines

1977
Effects of ACTH, adenyl compounds, and methylxanthines on goldfish erythrophores in culture.
    General and comparative endocrinology, 1977, Volume: 31, Issue:3

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adrenocorticotropic Hormone; Animals; Bucladesine; Caffeine; Cells, Cultured; Chromatophores; Cyclic AMP; Cytoplasmic Granules; Dose-Response Relationship, Drug; Goldfish; Kinetics; Microscopy, Phase-Contrast; Pigments, Biological; Theophylline; Xanthines

1977
The interaction of 4-alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes with cyclic adenosine 3',5'-monophosphate phosphodiesterase, and with cyclic adenosine 3',5'-monophosphate binding proteins.
    Biochemical pharmacology, 1977, May-01, Volume: 26, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Caffeine; Carrier Proteins; Cerebral Cortex; Cyclic AMP; In Vitro Techniques; Kinetics; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Protein Binding; Sheep; Theophylline

1977
Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors.
    Molecular pharmacology, 1977, Volume: 13, Issue:3

    Topics: Adenosine; Blood Platelets; Caffeine; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Depression, Chemical; Dipyridamole; Humans; In Vitro Techniques; Kinetics; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Platelet Aggregation; Theophylline

1977
Properties of human erythrocyte phosphatidylinositol kinase and inhibition by adenosine, ADP and related compounds.
    Biochimica et biophysica acta, 1977, Jun-23, Volume: 498, Issue:1

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Caffeine; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotides; Humans; Kinetics; Mercaptoethanol; Phosphatidylinositols; Phosphotransferases; Polyethylene Glycols; Theophylline

1977
Effect of cyclic-AMP and other compounds on electrical activity of neurohaemal tissue in Carausius.
    Journal of insect physiology, 1977, Volume: 23, Issue:4

    Topics: Action Potentials; Adenosine; Animals; Bucladesine; Caffeine; Cyclic AMP; Histamine; Insecta; Nervous System; Norepinephrine; Theophylline

1977
Biochemical studies of taste sensation: II. Labelling of cyclic AMP of bovine taste papillae in response to sweet and bitter stimuli.
    Journal of neuroscience research, 1976, Volume: 2, Issue:5-6

    Topics: Adenine; Animals; Caffeine; Cattle; Cyclic AMP; Epinephrine; Lactose; Quinine; Sucrose; Taste; Taste Buds; Theophylline

1976
Responses of proliferating cells to methylxanthines. Reversal of effect by colchicine.
    Experimental cell research, 1977, Volume: 108, Issue:1

    Topics: Aminophylline; Bucladesine; Caffeine; Cell Division; Cell Nucleus; Colchicine; Mitotic Index; Plant Cells; Theobromine; Theophylline; Xanthines

1977
The effects of methylxanthines on catecholamine-stimulated and normal chick embryos.
    Teratology, 1977, Volume: 16, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Abnormalities, Drug-Induced; Animals; Aortic Aneurysm; Aortic Arch Syndromes; Caffeine; Catecholamines; Chick Embryo; Drug Synergism; Epinephrine; Heart Defects, Congenital; Norepinephrine; Theophylline; Xanthines

1977
Evidence for the specific involvement of cyclic AMP in the olfactory transduction mechanism.
    Biochemical and biophysical research communications, 1977, Jul-25, Volume: 77, Issue:2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anura; Caffeine; Cyclic AMP; Electrophysiology; Etazolate; Odorants; Olfactory Mucosa; Phosphodiesterase Inhibitors; Rana temporaria; Smell; Theophylline

1977
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Jul-04, Volume: 285, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; Myometrium; Papaverine; Placenta; Pregnancy; Pregnancy Trimester, Third; Theophylline; Uterus

1977
Effect of phosphodiesterase inhibitors and dBcAMP on the inotropic and relaxing actions of histamine in cardiac muscle.
    European journal of pharmacology, 1977, Sep-15, Volume: 45, Issue:2

    Topics: Animals; Bucladesine; Caffeine; Drug Interactions; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Theophylline

1977
Increased spore yields of Clostridium perfringens in the presence of methylxanthines.
    Applied and environmental microbiology, 1977, Volume: 34, Issue:2

    Topics: Caffeine; Clostridium perfringens; Dextrins; Raffinose; Species Specificity; Spores, Bacterial; Theophylline; Xanthines

1977
Changes in cyclic AMP levels in the amphibian ovarian follicle following progesterone induction of meiotic maturation. Effect of phosphodiesterase inhibitors and exogenous calcium on germinal vesicle breakdown.
    Differentiation; research in biological diversity, 1977, Aug-11, Volume: 8, Issue:2

    Topics: Animals; Anura; Bucladesine; Caffeine; Calcium; Cyclic AMP; Female; Fertilization; Leucine; Meiosis; Ovarian Follicle; Phosphodiesterase Inhibitors; Progesterone; Rana pipiens; Theobromine; Theophylline

1977
Agar plate screening procedure for cyclic adenosine 3',5'-monophosphate and inhibitors of cyclic nucleotide phosphodiesterase.
    Applied and environmental microbiology, 1977, Volume: 34, Issue:5

    Topics: Adenylyl Cyclases; Agar; Bacteriological Techniques; Caffeine; Cyclic AMP; Escherichia coli; Fermentation; Galactose; Mutation; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Theophylline

1977
Effect of methylxanthines on binding of the glucocorticoid receptor to DNA-cellulose and nuclei.
    European journal of biochemistry, 1978, Jan-02, Volume: 82, Issue:1

    Topics: Adrenalectomy; Aminophylline; Animals; Caffeine; Cell Nucleus; Cyclic AMP; Cytosol; Dexamethasone; DNA; Kinetics; Liver; Male; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Theophylline; Xanthines

1978
The actions of adenosine and various nucleosides and nucleotides on the isolated toad spinal cord.
    General pharmacology, 1978, Volume: 9, Issue:4

    Topics: Animals; Anura; Caffeine; Electric Stimulation; In Vitro Techniques; Magnesium; Nucleosides; Nucleotides; Purine Nucleosides; Purine Nucleotides; Purines; Pyrimidines; Spinal Cord; Synaptic Transmission; Theophylline

1978
Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine.
    Biochemical pharmacology, 1978, Volume: 27, Issue:11

    Topics: Animals; Caffeine; Dogs; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Phosphoric Diester Hydrolases; Theophylline; Trachea; Uric Acid; Xanthines

1978
Ultraviolet light induction of skin carcinoma in the mouse; influence of cAMP modifying agents.
    Bulletin du cancer, 1978, Volume: 65, Issue:3

    Topics: Animals; Caffeine; Cyclic AMP; DNA Repair; Female; Mice; Neoplasms, Radiation-Induced; Phosphodiesterase Inhibitors; Skin; Skin Neoplasms; Theophylline; Ultraviolet Rays

1978
[Effect of ionizing radiation on cerebral phosphodiesterase].
    Eksperimentalna meditsina i morfologiia, 1978, Volume: 17, Issue:4

    Topics: Animals; Brain; Caffeine; Enzyme Activation; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Theophylline; Thiopental; Time Factors; X-Rays

1978
Effect of cyclic AMP on transformation and proliferation of leishmania cells.
    Tropenmedizin und Parasitologie, 1978, Volume: 29, Issue:4

    Topics: Bucladesine; Caffeine; Cyclic AMP; Humans; Leishmania; Morphogenesis; Papaverine; Theophylline

1978
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
    European journal of pharmacology, 1979, Feb-01, Volume: 53, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans; Male; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Xanthines

1979
Regulation of lipogenesis in adipocytes. Independent effects of thyroid hormones, cyclic AMP and insulin on the uptake of deoxy-D-glucose.
    Biochimica et biophysica acta, 1979, Jul-27, Volume: 574, Issue:1

    Topics: Adipose Tissue; Animals; Biological Transport; Bucladesine; Caffeine; Cyclic AMP; Deoxy Sugars; Deoxyglucose; Female; Insulin; Rats; Theophylline; Thyroidectomy

1979
Caffeine: its action on purine metabolizing enzymes.
    Biochemical and biophysical research communications, 1979, Nov-14, Volume: 91, Issue:1

    Topics: Adenine; Aminohydrolases; Animals; Caffeine; Crithidia; Cyclic AMP; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Leukocytes; N-Glycosyl Hydrolases; Pentosyltransferases; Purines; Theophylline

1979
Induction of alkaline phosphatase activity in HeLa cells by sodium butyrate.
    In vitro, 1979, Volume: 15, Issue:11

    Topics: Alkaline Phosphatase; Butyrates; Caffeine; Cyclic AMP; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Idoxuridine; Theophylline

1979
Cyclic 3',5'-adenosine monophosphate phosphodiesterase (cAMP PDE) and cyclic 3',5'-guanosine monophosphate phosphodiesterase (cGMP PDE) in microvessels isolated from bovine cortex.
    Neurochemical research, 1979, Volume: 4, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Calcium; Cattle; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Imidazoles; Magnesium; Microcirculation; Theobromine; Theophylline

1979
A characteristic of the rate response which is common to several compounds that stimulate the heart.
    Journal of molecular and cellular cardiology, 1975, Volume: 7, Issue:8

    Topics: Amitriptyline; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Heart Rate; Heterocyclic Compounds; Histamine; Male; Neurotransmitter Agents; Norepinephrine; Rabbits; Stimulation, Chemical; Theophylline

1975
Amphibian pancreas function in long-term organ culture: control of insulin release.
    General and comparative endocrinology, 1977, Volume: 33, Issue:1

    Topics: Alloxan; Amphibians; Animals; Aprotinin; Caffeine; Calcium; Culture Media; Epinephrine; Glucagon; Insulin; Insulin Secretion; Lasalocid; Organ Culture Techniques; Pancreas; Radioimmunoassay; Theophylline; Time Factors

1977
Comparative studies of the effects of drugs on X-ray-induced G2 delay.
    Radiation research, 1978, Volume: 74, Issue:1

    Topics: Benzimidazoles; Caffeine; Cell Cycle; Cells, Cultured; Dactinomycin; Deoxyadenosines; Dimethyl Sulfoxide; Lucanthone; Mitosis; RNA; Sulfhydryl Compounds; Theophylline; Time Factors; X-Rays

1978
Effect of methylxanthines and elevated external potassium on high energy phosphate content in frog skeletal muscle.
    Biochemical pharmacology, 1978, Volume: 27, Issue:24

    Topics: Animals; Anura; Caffeine; Calcium; Energy Metabolism; In Vitro Techniques; Muscles; Phosphates; Potassium; Rana pipiens; Sodium; Theophylline; Time Factors; Xanthines

1978
Use of saliva in therapeutic drug monitoring.
    Clinical chemistry, 1977, Volume: 23, Issue:2 PT. 1

    Topics: Antipyrine; Caffeine; Ethosuximide; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Primidone; Saliva; Theophylline

1977
Effects of methylxanthine drugs on pyrogen-induced hyperthermia.
    European journal of pharmacology, 1977, Oct-15, Volume: 45, Issue:4

    Topics: Animals; Caffeine; Female; Fever; Male; Pyrogens; Rabbits; Shigella dysenteriae; Theophylline; Time Factors; Xanthines

1977
Characterization of the uptake of the methylxanthines theophylline and caffeine in isolated pancreatic islets and their effect on D-glucose transport.
    Endocrinology, 1977, Volume: 101, Issue:6

    Topics: Animals; Biological Transport, Active; Caffeine; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Rats; Theophylline

1977
Comparison of homogeneous enzyme immunoassay and high-pressure liquid chromatography for the determination of theophylline concentration in serum.
    The American review of respiratory disease, 1978, Volume: 117, Issue:6

    Topics: Caffeine; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Theobromine; Theophylline

1978
Studies on the site of interaction for ninhydrin, alloxan, and D-glucose in insulin secretion by isolated islets in vitro.
    Endocrinology, 1979, Volume: 105, Issue:6

    Topics: Alloxan; Animals; Biological Transport; Caffeine; Cytochalasin B; Glucose; In Vitro Techniques; Indenes; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Ninhydrin; Rats; Theophylline

1979
[Stimulation of the synthesis and non-competitive inhibition of alkaline phosphatase by theophylline in normal hamster fibroblasts and absence of response in transformed fibroblasts].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, May-23, Volume: 284, Issue:20

    Topics: Alkaline Phosphatase; Animals; Caffeine; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Theophylline

1977
Plasma xanthine levels in low birthweight infants treated or not treated with theophylline.
    Archives of disease in childhood, 1979, Volume: 54, Issue:3

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Milk, Human; Theophylline; Xanthines

1979
Effect of calcium on strophanthidin-induced electrical and mechanical toxicity in cardiac Purkinje fibers.
    The American journal of physiology, 1979, Volume: 236, Issue:5

    Topics: Animals; Caffeine; Calcium; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Male; Membrane Potentials; Myocardial Contraction; Purkinje Fibers; Strophanthidin; Theophylline

1979
Interference of theophylline and caffeine in the gas-chromatographic estimation of phenobarbital.
    Clinical chemistry, 1979, Volume: 25, Issue:6

    Topics: Caffeine; Chromatography, Gas; Humans; Phenobarbital; Theophylline

1979
Metabolism of theophylline to caffeine in premature newborn infants.
    The Journal of pediatrics, 1979, Volume: 94, Issue:6

    Topics: Adult; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline

1979
Interconversion of theophylline and caffeine in newborn infants.
    The Journal of pediatrics, 1979, Volume: 94, Issue:6

    Topics: Age Factors; Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theobromine; Theophylline; Xanthines

1979
Caffeine, a metabolite of theophylline during the treatment of apnea in the premature infant.
    The Journal of pediatrics, 1979, Volume: 94, Issue:6

    Topics: Apnea; Caffeine; Half-Life; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline

1979
Effects of caffeine and D2O on persistence and de novo generation of intrinsic oscillatory contraction automaticity in Physarum.
    Cell and tissue research, 1979, Apr-12, Volume: 197, Issue:3

    Topics: Biological Transport, Active; Caffeine; Cell Membrane; Deuterium; Dose-Response Relationship, Drug; Movement; Physarum; Theophylline

1979
Caffeine intake and potential effect on health of a segment of northern Canadian indigenous people.
    The International journal of the addictions, 1979, Volume: 14, Issue:1

    Topics: Adult; Aged; Caffeine; Canada; Carbohydrate Metabolism; Coffee; Diet; Drug Utilization; Female; Health; Humans; Indians, North American; Male; Middle Aged; Tea; Theophylline

1979
Reduction of cholesterol synthesis by methylxanthines in cultured glial cells.
    Pediatric research, 1979, Volume: 13, Issue:10

    Topics: Aminophylline; Caffeine; Cells, Cultured; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Nerve Tissue Proteins; Neuroglia; Theophylline; Xanthines

1979
Theophylline acute poisoning in a child: evidence for biotransformation of theophylline into caffeine.
    Veterinary and human toxicology, 1979, Volume: 21 Suppl

    Topics: Biotransformation; Caffeine; Female; Humans; Infant; Theophylline

1979
[Contribution to the study of paracetamol-theophylline and paracetamol-caffeine associations (author's transl)].
    Annales pharmaceutiques francaises, 1979, Volume: 37, Issue:3-4

    Topics: Acetaminophen; Caffeine; Chemical Phenomena; Chemistry; Chemistry, Physical; Theophylline

1979
The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine.
    Cancer letters, 1979, Volume: 8, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Caffeine; DNA; Hypoxanthines; In Vitro Techniques; Mice; Microsomes, Liver; Stimulation, Chemical; Theobromine; Theophylline; Uric Acid

1979
Differential effects of cytochalasin B and caffeine on control of DNA synthesis in normal and transformed cells.
    Journal of cellular physiology, 1979, Volume: 101, Issue:2

    Topics: Animals; Caffeine; Cell Cycle; Cell Nucleus; Cell Transformation, Viral; Cytochalasin B; DNA; Fibroblasts; Humans; Mice; Papaverine; Theophylline

1979
Metabolism of theophylline to caffeine in human fetal liver.
    Science (New York, N.Y.), 1979, Dec-14, Volume: 206, Issue:4424

    Topics: Apnea; Biotransformation; Caffeine; Cells, Cultured; Gestational Age; Humans; Infant, Newborn; Liver; Methylation; Theophylline

1979
[Influence of glucagon, caffeine and theophylline on the active monosaccharide transport across the human spermatozoa cell membrane (author's transl)].
    Dermatologische Monatschrift, 1979, Volume: 165, Issue:7

    Topics: Biological Transport, Active; Caffeine; Cell Membrane Permeability; Fructose; Glucagon; Glucose; Humans; In Vitro Techniques; Male; Monosaccharides; Spermatozoa; Theophylline

1979
Simultaneous and specific determination of proxyphylline, theophylline and other xanthine derivatives in serum by high pressure liquid chromatography.
    Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:4

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines

1978
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.
    European journal of pharmacology, 1978, Jun-01, Volume: 49, Issue:3

    Topics: Acetylcholine; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Morphine; Rats; Theophylline; Xanthines

1978
Micro-method for the determination of caffeine and theophylline allowing direct application of biological fluids to thin-layer chromatography plates.
    Journal of chromatography, 1978, Jul-01, Volume: 146, Issue:1

    Topics: Apnea; Caffeine; Child; Child, Preschool; Chromatography, Thin Layer; Female; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Male; Microchemistry; Saliva; Theophylline

1978
Induction of alkaline phosphatase activity in HeLa cells by choline chloride.
    Cancer research, 1978, Volume: 38, Issue:11 Pt 1

    Topics: Alkaline Phosphatase; Caffeine; Cell Count; Choline; HeLa Cells; Hot Temperature; Idoxuridine; Phosphorylcholine; Sodium Chloride; Theophylline

1978
Interactions of caffeine and theophylline with p-cresol: UV studies.
    Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:10

    Topics: Caffeine; Chemical Phenomena; Chemistry; Cresols; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics

1978
[Caffeine-11C, ephedrine-11C and methylephedrine-11C: Synthesis and distribution in mice (author's transl)].
    Radioisotopes, 1978, Volume: 27, Issue:8

    Topics: Animals; Caffeine; Carbon Radioisotopes; Ephedrine; Isotope Labeling; Male; Methylation; Mice; Phenylpropanolamine; Theophylline; Time Factors; Tissue Distribution

1978
[Mass spectrophotometric degradation of theophyllidine, caffeidine and the methylxanthines caffeine, theophylline and theobromine].
    Die Pharmazie, 1978, Volume: 33, Issue:11

    Topics: Caffeine; Chemical Phenomena; Chemistry; Drug Stability; Mass Spectrometry; Theobromine; Theophylline

1978
Inhibition of skin carcinogenesis in vivo by caffeine and other agents.
    National Cancer Institute monograph, 1978, Issue:50

    Topics: Animals; Caffeine; Cell Line; Chloroquine; DNA; DNA Repair; Female; Malondialdehyde; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Theophylline; Ultraviolet Rays

1978
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations.
    Hereditas, 1975, Volume: 79, Issue:1

    Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug Synergism; Methylation; Mutation; Plants; Purines; Theobromine; Theophylline; Thiotepa; Uric Acid

1975
A physicochemical analysis of conjugation in Tetrahymena pyriformis.
    Experimental cell research, 1976, Volume: 97, Issue:2

    Topics: Amino Acids; Animals; Caffeine; Calcium; Colchicine; Conjugation, Genetic; Culture Media; Cycloheximide; Dactinomycin; Dithiothreitol; Egtazic Acid; Kinetics; Magnesium; Manganese; Potassium; Sodium; Temperature; Tetrahymena pyriformis; Theophylline; Zinc

1976
Caffeine, theophylline, and human sperm motility.
    Fertility and sterility, 1976, Volume: 27, Issue:5

    Topics: Animals; Caffeine; Haplorhini; In Vitro Techniques; Male; Semen; Specimen Handling; Sperm Motility; Theophylline

1976
The promoting ability of five accelerating agents for diazotization of several types of bilirubin samples.
    Clinical chemistry, 1977, Volume: 23, Issue:4

    Topics: Acetates; Benzoates; Bilirubin; Caffeine; Chemical Phenomena; Chemistry; Evaluation Studies as Topic; Humans; Indicators and Reagents; Jaundice; Theophylline; Urea

1977
Inhibitory effect of xanthines on the incorporation of [14C]valine into proteins and on the secretion of albumin in isolated parenchymal rat liver cells.
    Biochemical pharmacology, 1977, Mar-15, Volume: 26, Issue:6

    Topics: Aminophylline; Animals; Caffeine; Female; In Vitro Techniques; Liver; Protein Biosynthesis; Rats; Serum Albumin; Theophylline; Valine

1977
An assay for inorganic orthophosphate in the presence of alkaloids and related drugs.
    Biochemical medicine, 1977, Volume: 17, Issue:2

    Topics: Alkaloids; Atropine; Caffeine; Methods; Molybdenum; Phosphates; Quinine; Theophylline

1977
Simultaneous assay of the methylxanthine metabolites of caffeine in plasma by high performance liquid chromatography.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 17, Issue:2

    Topics: Caffeine; Chromatography, Liquid; Humans; Theobromine; Theophylline; Xanthines

1977
High performance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma.
    Biomedical mass spectrometry, 1977, Volume: 4, Issue:3

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Theobromine; Theophylline; Xanthines

1977
Effects of gastrointestinal hormones on the electrical and mechanical activity of the cat stomach.
    The Tohoku journal of experimental medicine, 1977, Volume: 122, Issue:3

    Topics: Action Potentials; Animals; Atropine; Caffeine; Cats; Cholecystokinin; Gastrins; Gastrointestinal Hormones; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Secretin; Stomach; Tetrodotoxin; Theophylline; Verapamil

1977
Action of caffeine and theophylline on staphylococcal penicillinase synthesis.
    Chemotherapy, 1977, Volume: 23, Issue:6

    Topics: Caffeine; Penicillinase; Staphylococcus aureus; Theophylline

1977
Methylxanthines and intestinal drug absorption.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:1

    Topics: Animals; Antipyrine; Caffeine; Female; Intestinal Absorption; Jejunum; Male; Pharmaceutical Preparations; Rats; Regional Blood Flow; Salicylates; Theophylline; Tritium; Urea; Water

1976
Theophylline radioimmunoassay: synthesis of antigen and characterization of antiserum.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:3

    Topics: Animals; Antibody Formation; Caffeine; Cross Reactions; Female; Immune Sera; Male; Microchemistry; Rabbits; Radioimmunoassay; Saliva; Serum Albumin, Bovine; Theobromine; Theophylline

1976
A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates.
    Clinica chimica acta; international journal of clinical chemistry, 1976, Jun-15, Volume: 69, Issue:3

    Topics: Barbiturates; Caffeine; Humans; Hypoxanthines; Spectrophotometry, Ultraviolet; Theophylline; Uric Acid; Xanthines

1976
[Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with liver disease].
    Zeitschrift fur Ernahrungswissenschaft, 1976, Volume: 15, Issue:1

    Topics: Caffeine; Coffee; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Liver Diseases; Theophylline; Triglycerides

1976
[Study on the effect of detection with iodine on the determination of aromatic compounds after their chromatographic separation, XII].
    Ceskoslovenska farmacie, 1976, Volume: 25, Issue:5

    Topics: Aminopyrine; Antipyrine; Barbiturates; Caffeine; Chromatography, Thin Layer; Iodine; Mass Spectrometry; Theophylline

1976
Quantitative determination of theophylline in pharmaceutical dosage forms by differential spectrophotometry.
    Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:8

    Topics: Amobarbital; Caffeine; Capsules; Chemical Phenomena; Chemistry; Drug Stability; Ephedrine; Methods; Spectrophotometry, Ultraviolet; Tablets; Theobromine; Theophylline

1976
A rapid and sensitive method for determination of theophylline in plasma and saliva by high pressure liquid chromatography.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 15, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Methods; Saliva; Theobromine; Theophylline

1976
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
    Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:3

    Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myocarditis; Myocardium; Necrosis; Oxygen Consumption; Propranolol; Rats; Theophylline; Verapamil

1976
[Structure and organization of the contractile proteins at the level of the Z and M bands in the sartorius muscles of Rana esculenta treated with methylxanthine (MX)].
    Bollettino della Societa italiana di biologia sperimentale, 1976, May-15, Volume: 52, Issue:9

    Topics: Animals; Caffeine; Muscle Contraction; Muscle Proteins; Muscles; Rana esculenta; Theophylline; Xanthines

1976
The effect of methylxanthines on chromosomes of human lyphocytes in culture.
    Mutation research, 1975, Volume: 31, Issue:1

    Topics: Caffeine; Cells, Cultured; Chromosomes; Humans; Lymphocytes; Mitosis; Mutagens; Theobromine; Theophylline; Time Factors; Xanthines

1975
The xanthine treatment of apnea of prematurity.
    Pediatrics, 1975, Volume: 55, Issue:5

    Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Diseases; Prognosis; Theophylline; Xanthines

1975
Gas-liquid chromatographic determination of theophylline in human plasma.
    Journal of chromatography, 1975, Jan-29, Volume: 104, Issue:1

    Topics: Caffeine; Chromatography, Gas; Hot Temperature; Humans; Methods; Methylation; Microchemistry; Theophylline

1975
Action of dopamine receptor agonists in forebrain and hypothalamus: rotational behavior, ovulation, and dopamine turnover.
    Advances in neurology, 1975, Volume: 9

    Topics: Animals; Apomorphine; Brain; Caffeine; Dopamine; Ergot Alkaloids; Female; Hypothalamus; Limbic System; Lysergic Acid Diethylamide; Models, Biological; Motor Activity; Ovulation; Piribedil; Receptors, Drug; Sexual Behavior, Animal; Stimulation, Chemical; Telencephalon; Theophylline

1975
Stimulatory effect of the lysosomal stabilizer, chloroquine, on the respiration and motility of fresh and aged bovine spermatozoa.
    Journal of reproduction and fertility, 1975, Volume: 44, Issue:3

    Topics: Animals; Caffeine; Cattle; Chloroquine; In Vitro Techniques; Male; Oxygen Consumption; Sperm Motility; Sperm Tail; Spermatozoa; Stimulation, Chemical; Theophylline; Tissue Preservation

1975
Effect of methylxanthines on hepatic microsomal enzymes in the rat.
    Toxicology and applied pharmacology, 1975, Volume: 33, Issue:3

    Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Caffeine; Male; Microsomes, Liver; Nitroanisole O-Demethylase; Proteins; Rats; Theobromine; Theophylline; Time Factors

1975
[Separation of caffeine, theophylline and theobromine with assistance from high pressure liquid chromatography].
    Journal of chromatography, 1975, Nov-26, Volume: 114, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Theobromine; Theophylline

1975
The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells.
    Mutation research, 1975, Volume: 30, Issue:2

    Topics: Animals; Caffeine; Cell Line; Chromosome Aberrations; Cricetinae; DNA; DNA Repair; Molecular Weight; Purines; Radiation Genetics; Theophylline; Ultraviolet Rays

1975
A rapid and precise method for determining theophylline in serum.
    Clinical toxicology, 1975, Volume: 8, Issue:5

    Topics: Barbiturates; Caffeine; Humans; Methods; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

1975
Which of caffeine's chemical relatives are able to evoke contractures in mammalian heart?
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 7

    Topics: Animals; Caffeine; Guinea Pigs; Heart Ventricles; Imidazoles; In Vitro Techniques; Myocardial Contraction; Rats; Structure-Activity Relationship; Temperature; Theobromine; Theophylline; Ventricular Function; Xanthines

1975
[Broncholytic effect of Atrovent in comparison with a combination preparation in obstructive lung diseases].
    Wiener medizinische Wochenschrift (1946), 1975, Dec-05, Volume: 125, Issue:49

    Topics: Adult; Aged; Atropa belladonna; Atropine; Bronchodilator Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Papaverine; Phenazines; Phytotherapy; Plants, Medicinal; Plants, Toxic; Theophylline; Tropanes

1975
Determination of theophylline in plasma ultrafiltrate by reversed phase high pressure liquid chromatography.
    Analytical chemistry, 1976, Volume: 48, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Methods; Theophylline; Ultrafiltration; Xanthines

1976
The human metabolism of caffeine to theophylline.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:2

    Topics: Allopurinol; Aminophylline; Biological Availability; Caffeine; Humans; Male; Theophylline; Time Factors

1976
Gas-chromatographic micro-scale procedure for theophylline, with use of a nitrogen-sensitive detector.
    Clinical chemistry, 1976, Volume: 22, Issue:6

    Topics: Caffeine; Chromatography, Gas; Humans; Microchemistry; Nitrogen; Phenobarbital; Saliva; Theobromine; Theophylline; Xanthines

1976
Serum theophylline analysis by high-pressure liquid chromatography.
    Clinical chemistry, 1976, Volume: 22, Issue:6

    Topics: Caffeine; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Microchemistry; Structure-Activity Relationship; Theobromine; Theophylline

1976
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
    European journal of pharmacology, 1992, Nov-03, Volume: 222, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Caffeine; Electroencephalography; Male; Parasympatholytics; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines

1992
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
    Pharmacogenetics, 1992, Volume: 2, Issue:2

    Topics: Biotransformation; Caffeine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA; Gene Expression; Humans; Oxidoreductases; Oxidoreductases, N-Demethylating; Theobromine; Theophylline; Vaccinia virus

1992
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
    Circulation research, 1992, Volume: 71, Issue:5

    Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardium; Myosins; Rats; Rats, Wistar; Theophylline; Thyroid Hormones

1992
Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicans.
    Mycopathologia, 1992, Volume: 119, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine Nucleotides; Adenosine; Caffeine; Candida albicans; Cyclic AMP; Theophylline

1992
Hypoxia-specific inhibition of recovery from radiation damage by a novel 2-nitroimidazole with a theophylline side chain.
    International journal of radiation biology, 1992, Volume: 61, Issue:6

    Topics: Animals; Caffeine; Cell Hypoxia; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Theophylline

1992
Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility.
    Journal of ocular pharmacology, 1992,Summer, Volume: 8, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aqueous Humor; Caffeine; Cattle; Ciliary Body; Muscle Contraction; Perfusion; Phosphodiesterase Inhibitors; Theophylline

1992
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
    Mutation research, 1992, Volume: 269, Issue:2

    Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid

1992
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline

1992
A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites.
    International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:9

    Topics: Adult; Caffeine; Evaluation Studies as Topic; Female; Humans; Liver; Liver Cirrhosis; Male; Methods; Middle Aged; Oxidation-Reduction; Theobromine; Theophylline

1992
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
    Calcified tissue international, 1992, Volume: 51, Issue:6

    Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Theophylline

1992
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Inositol; Male; Mice; Phenytoin; Structure-Activity Relationship; Theophylline; Uric Acid

1992
Caffeine and theophylline contractures in tonic skeletal muscle fibers of the frog.
    The Japanese journal of physiology, 1992, Volume: 42, Issue:5

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Contracture; Dose-Response Relationship, Drug; Electrophysiology; Muscle Contraction; Rana pipiens; Sarcoplasmic Reticulum; Theophylline

1992
Behavioral evaluation of psycho-pharmacological and psychotoxic actions of methylxanthines by ambulatory activity and discrete avoidance in mice.
    The Journal of toxicological sciences, 1992, Volume: 17, Issue:2

    Topics: Animals; Avoidance Learning; Caffeine; Male; Methamphetamine; Mice; Motor Activity; Theobromine; Theophylline

1992
Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:5

    Topics: 4-Quinolones; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; Oxidoreductases; Theophylline

1992
Fluorescence quenching of human serum albumin by xanthines.
    Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4

    Topics: Caffeine; Humans; Serum Albumin; Spectrometry, Fluorescence; Temperature; Theobromine; Theophylline; Thermodynamics; Tryptophan; Xanthines

1992
Pharmacodynamic interactions between isoniazid and theophylline in mice and rats, and the influence of pyridoxine.
    Die Pharmazie, 1992, Volume: 47, Issue:7

    Topics: Animals; Brain; Caffeine; Convulsants; Drug Interactions; Isoniazid; Male; Mice; Pyridoxine; Rats; Rats, Inbred Strains; Theophylline

1992
Purinergic agonist induction of metallothionein.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 201, Issue:1

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cells, Cultured; Cladribine; Deoxyadenosines; Dose-Response Relationship, Drug; Immunoblotting; Liver; Male; Metallothionein; Rats; Rats, Inbred Strains; RNA, Messenger; Theophylline; Time Factors; Transcription, Genetic; Vasodilator Agents

1992
Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:1

    Topics: Apnea; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Theobromine; Theophylline

1992
Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes.
    Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:3

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Diet Records; Educational Status; Female; Hispanic or Latino; Humans; Milk, Human; Socioeconomic Factors; Theobromine; Theophylline; White People

1992
[Behavioral study on reduction of psychotic and behavioral disorders induced by antitussive and expectorant].
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1992, Volume: 27, Issue:2

    Topics: Animals; Antitussive Agents; Avoidance Learning; Behavior, Animal; Caffeine; Expectorants; Male; Mice; Mice, Inbred Strains; Motor Activity; Psychoses, Substance-Induced; Theophylline

1992
Caffeine concentrations in adult patients chronically taking theophylline.
    Clinical chemistry, 1992, Volume: 38, Issue:7

    Topics: Adult; Aged; Caffeine; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Theophylline

1992
Theophylline metabolism affected by mexiletine.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1

    Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines

1992
Simultaneous determination of caffeine and its primary demethylated metabolites in human plasma by high-performance liquid chromatography.
    Journal of chromatography, 1992, Mar-27, Volume: 575, Issue:2

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Humans; Male; Middle Aged; Theobromine; Theophylline

1992
Methylxanthines (caffeine and theophylline) blocked methamphetamine-induced conditioned place preference in mice but enhanced that induced by cocaine.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Animals; Caffeine; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Methamphetamine; Mice; Mice, Inbred Strains; Theophylline

1992
A Monte Carlo simulation of hydration of xanthine-derivatives and their stacked forms.
    Journal of biomolecular structure & dynamics, 1992, Volume: 9, Issue:6

    Topics: Caffeine; Molecular Conformation; Monte Carlo Method; Theobromine; Theophylline; Thermodynamics; Water; Xanthines

1992
Determination of substituted purines in body fluids by micellar electrokinetic capillary chromatography with direct sample injection.
    Journal of chromatography, 1992, Feb-28, Volume: 593, Issue:1-2

    Topics: Adult; Body Fluids; Caffeine; Chromatography; Electrophoresis; Humans; Infant; Purines; Saliva; Theophylline

1992
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
    European journal of pharmacology, 1990, Jan-10, Volume: 175, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Cerebral Cortex; Colforsin; Cyclic AMP; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1990
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells.
    The Journal of biological chemistry, 1990, Apr-15, Volume: 265, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Histones; Mice; Neuroblastoma; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Theophylline; Tumor Cells, Cultured; Tyrosine

1990
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
    Molecular pharmacology, 1990, Volume: 37, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine

1990
V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:23

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; B-Lymphocytes; Blotting, Northern; Caffeine; Cell Line; Cyclic AMP; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Kinetics; Mice; Plasmids; Recombination, Genetic; RNA, Messenger; T-Lymphocytes; Theophylline; Transfection

1990
Free calcium transients and oscillations in nerve cells.
    Experimental brain research, 1991, Volume: 83, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Fura-2; Guanylyl Imidodiphosphate; Helix, Snails; Membrane Potentials; Microelectrodes; Neurons; Theophylline; Thymol; Xanthines

1991
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
    Biochemical pharmacology, 1992, Jan-22, Volume: 43, Issue:2

    Topics: Animals; Biotransformation; Caffeine; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Genetic Engineering; Humans; Hydroxylation; Methylation; Mice; Rats; Species Specificity; Theophylline; Xanthines

1992
Purinergic modulation of field stimulation responses of rat and human vas deferens smooth muscle.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Electric Stimulation; Guanethidine; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinidine; Rats; Receptors, Purinergic; Theophylline; Urinary Bladder; Vas Deferens; Vasodilator Agents

1991
Determination of theophylline in serum and saliva in the presence of caffeine and its metabolites.
    Journal of chromatography, 1991, Jul-17, Volume: 568, Issue:1

    Topics: Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Saliva; Theophylline

1991
Xanthines inhibit 3T3 fibroblast proliferation.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1991, Volume: 4, Issue:4

    Topics: 3T3 Cells; Animals; Caffeine; Cell Division; Dyphylline; Mice; Psoriasis; Theophylline; Xanthines

1991
Somatic development of the infant monkey following in utero exposure to caffeine.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 17, Issue:3

    Topics: Animals; Body Weight; Caffeine; Female; Half-Life; Humans; Infant, Newborn; Macaca fascicularis; Male; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Teratogens; Theophylline

1991
Methylxanthine-induced attenuation of pecking in chickens.
    British journal of pharmacology, 1991, Volume: 104, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Behavior, Animal; Caffeine; Chickens; Dipyridamole; Female; Male; Theophylline; Xanthines

1991
High-performance liquid chromatographic separation of caffeine, theophylline, theobromine and paraxanthine in rat brain and serum.
    Journal of chromatography, 1991, Sep-18, Volume: 570, Issue:1

    Topics: Animals; Brain Chemistry; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

1991
Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives.
    Neuroscience letters, 1991, Dec-09, Volume: 133, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Affinity Labels; Animals; Biological Transport; Caffeine; Cells, Cultured; Cytarabine; Dipyridamole; Embryo, Mammalian; Hippocampus; Kinetics; Neuroglia; Neurons; Pentoxifylline; Rats; Sodium; Theophylline; Thioinosine; Tritium; Xanthines

1991
Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice.
    European journal of pharmacology, 1991, Jan-03, Volume: 192, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bromocriptine; Caffeine; Dopamine; Male; Mice; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sulpiride; Synapses; Theophylline; Xanthines

1991
Lack of pharmacokinetic interaction as an equivalence problem.
    International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Adenosine Triphosphatases; Administration, Oral; Adult; Benzimidazoles; Caffeine; Drug Interactions; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Omeprazole; Pantoprazole; Pharmacokinetics; Sulfoxides; Theophylline; Therapeutic Equivalency

1991
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
    European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3

    Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea

1991
Caffeine and theophylline as adenosine receptor antagonists in humans.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Aggregation; Purinergic Antagonists; Receptors, Purinergic; Substance Withdrawal Syndrome; Theophylline

1991
Significance of partial and total cohesion parameters of pharmaceutical solids determined from dissolution calorimetric measurements.
    Pharmaceutical research, 1991, Volume: 8, Issue:5

    Topics: Caffeine; Calorimetry; Dosage Forms; Drug Compounding; Models, Chemical; Phenylbutazone; Solubility; Technology, Pharmaceutical; Theophylline; Thermodynamics

1991
[Micromethod for determination of theophylline/caffeine and chloramphenicol in plasma with HPLC].
    Die Pharmazie, 1991, Volume: 46, Issue:3

    Topics: Caffeine; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Microchemistry; Theophylline

1991
Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue.
    International journal of obesity, 1991, Volume: 15, Issue:5

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Ephedrine; Male; Oxygen Consumption; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline; Xanthines

1991
Dissociation between the effects of theophylline and caffeine on premature airway smooth muscles.
    Pediatric research, 1991, Volume: 29, Issue:5

    Topics: Acetylcholine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Female; Humans; Infant, Newborn; Isometric Contraction; Muscle Relaxation; Muscle, Smooth; Pregnancy; Respiratory Distress Syndrome, Newborn; Sheep; Theophylline; Trachea

1991
Pharmacokinetic aspects of caffeine in premature infants.
    Developmental pharmacology and therapeutics, 1991, Volume: 16, Issue:3

    Topics: Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature; Injections, Intravenous; Sleep Apnea Syndromes; Theophylline; Xanthines

1991
Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline.
    Life sciences, 1991, Volume: 49, Issue:24

    Topics: Adipose Tissue; Analysis of Variance; Animals; Brain; Caffeine; Dialysis; Extracellular Space; In Vitro Techniques; Least-Squares Analysis; Liver; Male; Muscles; Organ Specificity; Rats; Rats, Inbred Strains; Theophylline

1991
Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain and other tissues in rats.
    Life sciences, 1991, Volume: 49, Issue:24

    Topics: Adipose Tissue; Animals; Brain; Caffeine; Dialysis; Extracellular Space; Least-Squares Analysis; Liver; Male; Muscles; Rats; Rats, Inbred Strains; Theophylline

1991
Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons.
    Neuroscience letters, 1990, Nov-27, Volume: 120, Issue:1

    Topics: Animals; Barium; Caffeine; Calcium Channels; Ganglia; Helix, Snails; In Vitro Techniques; Lypressin; Membrane Potentials; Neurons; Oxytocin; Phosphodiesterase Inhibitors; Theophylline; Xanthines

1990
Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity.
    International journal of radiation biology, 1990, Volume: 57, Issue:6

    Topics: Caffeine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Mitosis; Theobromine; Theophylline; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xanthines

1990
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
Effects of the anesthetics heptanol, halothane and isoflurane on gap junction conductance in crayfish septate axons: a calcium- and hydrogen-independent phenomenon potentiated by caffeine and theophylline, and inhibited by 4-aminopyridine.
    The Journal of membrane biology, 1991, Volume: 121, Issue:1

    Topics: 4-Aminopyridine; Alcohols; Anesthetics; Animals; Astacoidea; Axons; Caffeine; Calcium; Electric Conductivity; Halothane; Heptanol; Hydrogen-Ion Concentration; Intercellular Junctions; Isoflurane; Kinetics; Membrane Potentials; Theophylline

1991
[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea].
    Anales espanoles de pediatria, 1991, Volume: 34, Issue:4

    Topics: Apnea; Asphyxia Neonatorum; Caffeine; Humans; Infant, Newborn; Monitoring, Physiologic; Theophylline

1991
Interval dependence of force and twitch duration in rat heart explained by Ca2+ pump inactivation in sarcoplasmic reticulum.
    The Journal of physiology, 1990, Volume: 431

    Topics: Action Potentials; Animals; Biological Transport, Active; Biomechanical Phenomena; Caffeine; Calcium; Female; In Vitro Techniques; Male; Myocardial Contraction; Rats; Ryanodine; Sarcomeres; Sarcoplasmic Reticulum; Sodium; Strontium; Theophylline; Time Factors

1990
Organic calcium channel antagonists provoke acetylcholine receptor autodesensitization on train stimulation of motor nerve.
    Neuroscience, 1990, Volume: 38, Issue:3

    Topics: Animals; Bungarotoxins; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diaphragm; Egtazic Acid; Electric Stimulation; Electrophysiology; Mice; Motor Endplate; Muscle Contraction; Neostigmine; Nicardipine; Phrenic Nerve; Receptors, Cholinergic; Theophylline

1990
Urinary zinc excretion in infancy.
    Journal of trace elements and electrolytes in health and disease, 1990, Volume: 4, Issue:1

    Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of Results; Specimen Handling; Spectrophotometry, Atomic; Theophylline; Zinc

1990
The effects of caffeine and theophylline on the triple adenosine triphosphatase enzyme activities of spermatozoa from males with oligoasthenospermia.
    European urology, 1990, Volume: 17, Issue:1

    Topics: Adenosine Triphosphatases; Caffeine; Humans; Male; Sperm Motility; Spermatozoa; Theophylline

1990
Relationships between adenylate cyclase and Na+, K(+)-ATPase in rat pancreatic islets.
    The Journal of biological chemistry, 1990, Mar-05, Volume: 265, Issue:7

    Topics: Adenylyl Cyclases; Animals; Brain; Bucladesine; Caffeine; Cell Membrane; In Vitro Techniques; Islets of Langerhans; Kidney Medulla; Kinetics; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Swine; Theophylline

1990
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
    Psychopharmacology, 1990, Volume: 100, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines

1990
Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; C-Reactive Protein; Caffeine; Calcimycin; Calcium; Carcinoma, Hepatocellular; Colforsin; Cyclic AMP; Drug Synergism; Humans; Interleukin-1; Interleukin-6; Ionomycin; Liver Neoplasms; Recombinant Proteins; Second Messenger Systems; Theophylline; Tumor Cells, Cultured

1990
Determination of anticonvulsant drugs and methyl xanthine derivatives in serum by liquid chromatography with direct injection: column-switching method using a new internal-surface reversed-phase silica support as a precolumn.
    Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2

    Topics: Anticonvulsants; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Phenobarbital; Phenytoin; Primidone; Silicon Dioxide; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines

1990
Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes.
    European journal of pharmacology, 1990, Apr-25, Volume: 179, Issue:3

    Topics: Animals; Benzazepines; Binding, Competitive; Brain; Caffeine; Corpus Striatum; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Membranes; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Theophylline

1990
Recombinagenicity of caffeine for Candida albicans.
    Mycopathologia, 1990, Volume: 110, Issue:2

    Topics: Adenine; Caffeine; Candida albicans; Cell Division; Culture Media; DNA Damage; DNA Repair; DNA, Fungal; Drug Resistance, Microbial; Flucytosine; Mutation; Phenotype; Recombination, Genetic; Temperature; Theophylline

1990
The effect of methylxanthines on milk volume and composition, and growth of rat pups.
    The British journal of nutrition, 1990, Volume: 64, Issue:2

    Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Fatty Acids; Female; Lactation; Milk; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Time Factors; Xanthines

1990
Do-Do abuse.
    The British journal of psychiatry : the journal of mental science, 1990, Volume: 157

    Topics: Adult; Antitussive Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline

1990
Caffeine and theophylline attenuate adenosine-induced vasodilation in humans.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:4

    Topics: Adenosine; Adolescent; Adult; Bronchodilator Agents; Caffeine; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Theophylline; Vasodilation; Xanthines

1990
Isobolographic assessment of the convulsant interaction between theophylline and caffeine or pentylenetetrazol in rats.
    Journal of pharmaceutical sciences, 1990, Volume: 79, Issue:8

    Topics: Animals; Caffeine; Convulsants; Drug Interactions; Infusions, Intravenous; Male; Models, Biological; Pentylenetetrazole; Rats; Rats, Inbred Strains; Theophylline

1990
Effect of methylxanthines on lactational performance of rats.
    Annals of nutrition & metabolism, 1990, Volume: 34, Issue:5

    Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Drinking; Eating; Female; Lactation; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1990
Adenosine involvement in postictal events in amygdala-kindled rats.
    Epilepsy research, 1990, Volume: 6, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Caffeine; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Kindling, Neurologic; Male; Rats; Seizures; Theophylline; Time Factors

1990
HPLC analysis of methylxanthines in human breast milk.
    Journal of chromatographic science, 1990, Volume: 28, Issue:12

    Topics: Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Milk, Human; Temperature; Theobromine; Theophylline; Xanthines

1990
Methylcholanthrene but not phenobarbital enhances caffeine and theophylline metabolism in cultured adult human hepatocytes.
    Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1

    Topics: Adult; Biotransformation; Caffeine; Cells, Cultured; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Theophylline

1990
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1990
Simpler measurement of caffeine and paraxanthine in saliva.
    Clinical chemistry, 1990, Volume: 36, Issue:2

    Topics: Autoanalysis; Caffeine; Humans; Saliva; Theophylline

1990
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1990, Volume: 193, Issue:3

    Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobromine; Theophylline

1990
Maternal caffeine ingestion increases the tyrosine level in neonatal rat cerebrum.
    Biology of the neonate, 1990, Volume: 57, Issue:2

    Topics: Amino Acids; Animals; Animals, Newborn; Animals, Suckling; Brain; Caffeine; Female; Liver; Maternal-Fetal Exchange; Methoxyhydroxyphenylglycol; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Theophylline; Tyrosine

1990
Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:1

    Topics: Adult; Caffeine; Fatty Acids, Nonesterified; Glycerol; Humans; Injections, Intravenous; Lipid Mobilization; Lipolysis; Male; Theophylline

1990
Transcutaneous theophylline collection in preterm infants.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Age Factors; Caffeine; Diffusion; Humans; Infant, Newborn; Infant, Premature; Lung Diseases; Methods; Permeability; Skin; Theophylline

1990
Human N-acetylation genotype determination with urinary caffeine metabolites.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines

1990
Caffeine and methylxanthines.
    Chest, 1990, Volume: 97, Issue:5

    Topics: Caffeine; Dipyridamole; Drug Interactions; Humans; Theophylline

1990
[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:3

    Topics: Bradycardia; Caffeine; Citrates; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Determination; Gastroesophageal Reflux; Humans; Infant, Newborn; Respiration; Respiratory Distress Syndrome, Newborn; Sleep Apnea Syndromes; Theophylline

1990
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants.
    Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, Purinergic; Theophylline; Trachea; Xanthines

1990
Simultaneous analysis of theophylline, caffeine and eight of their metabolic products in human plasma by gradient high-performance liquid chromatography.
    Journal of chromatography, 1990, May-16, Volume: 507

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Xanthines

1990
Methylxanthines inhibit glucose transport in rat adipocytes by two independent mechanisms.
    Biochemical pharmacology, 1990, Sep-01, Volume: 40, Issue:5

    Topics: Adipose Tissue; Animals; Caffeine; Cell Membrane; Glucose; Rats; Rats, Inbred Strains; Theophylline; Xanthines

1990
Determination of carcinogenic arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites.
    Progress in clinical and biological research, 1990, Volume: 340B

    Topics: Acetylation; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Cytochrome P-450 Enzyme System; Disease Susceptibility; Humans; Isoenzymes; Oxidation-Reduction; Phenotype; Theophylline; Uracil; Urinary Bladder Neoplasms; Xanthines

1990
A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:4

    Topics: Animals; Brain; Caffeine; Flavins; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reference Values; Sleep; Sleep Stages; Sleep, REM; Theophylline

1990
[Action of cyclic nucleotide phosphodiesterase inhibitors on the acetylcholine potential].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Bucladesine; Caffeine; Diaphragm; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Theophylline

1985
Regulation of galactokinase gene expression in Tetrahymena thermophila. I. Intracellular catecholamine control of galactokinase expression.
    The Journal of biological chemistry, 1985, Aug-25, Volume: 260, Issue:18

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Caffeine; Catecholamines; Cyclic AMP; Galactokinase; Genes; Glucagon; Glucose; Histamine; Insulin; Kinetics; Tetrahymena; Theophylline

1985
Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Chlordiazepoxide; Conditioning, Psychological; Male; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Saimiri; Theobromine; Theophylline; Xanthines

1985
The effect of caffeine on mouse striatal tryptamine.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: Animals; Caffeine; Corpus Striatum; Hydroxyindoleacetic Acid; Male; Mice; Pargyline; Serotonin; Theophylline; Tryptamines; Tryptophan

1985
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity.
    Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Glucose; Glucose-6-Phosphate; Glucosephosphates; Liver; Male; Phosphoprotein Phosphatases; Rats; Structure-Activity Relationship; Theobromine; Theophylline; Time Factors; Xanthine; Xanthines

1986
Lack of a sustained effect on catecholamines or indoles in mouse brain after long term subcutaneous administration of caffeine and theophylline.
    Life sciences, 1986, Aug-11, Volume: 39, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Caffeine; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; Norepinephrine; Serotonin; Theophylline

1986
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines

1986
Enhancement and suppression of currents related to calcium-overload by different concentrations of methylxanthines.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 282, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Ion Channels; Male; Microelectrodes; Purkinje Fibers; Sheep; Theophylline; Xanthines

1986
Effect of chronically administered methylxanthines on ethanol-induced motor incoordination in mice.
    Life sciences, 1986, Oct-20, Volume: 39, Issue:16

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Caffeine; Drug Synergism; Ethanol; Kinetics; Male; Mice; Motor Activity; Receptors, Purinergic; Theophylline; Xanthines

1986
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1986
Behavioral interactions of ethanol and methylxanthines.
    Psychopharmacology, 1987, Volume: 91, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Posture; Psychomotor Performance; Reflex; Theophylline; Xanthines

1987
Effects of methylxanthines on cell-cycle redistribution and sensitization to killing by low-dose-rate radiation.
    NCI monographs : a publication of the National Cancer Institute, 1988, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cell Cycle; Cell Survival; Humans; Radiation Dosage; Radiation Tolerance; Theophylline; Tumor Cells, Cultured

1988
Effects of caffeine and 3-isobutyl 1-methyl xanthine on caprine milk secretion.
    Journal of dairy science, 1988, Volume: 71, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Fats; Female; Goats; Infusions, Intravenous; Injections, Intramuscular; Lactation; Milk; Milk Proteins; Pregnancy; Theophylline

1988
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cholera Toxin; Colforsin; Cyclic AMP; Evoked Potentials; Fluorides; In Vitro Techniques; Mice; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Theophylline

1988
Calcium dependence of rhythmic contractions of the Oryzias latipes blastoderm.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 89, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastoderm; Bucladesine; Caffeine; Calcium; Calcium Channel Blockers; Cyprinodontiformes; Oryzias; Papaverine; Theophylline

1988
Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors.
    Life sciences, 1988, Volume: 43, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Calcium; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Theophylline

1988
Cyclic nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid hormone and 16,16-dimethyl prostaglandin E2 in chicks.
    Calcified tissue international, 1989, Volume: 44, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 16,16-Dimethylprostaglandin E2; Animals; Bone and Bones; Bucladesine; Caffeine; Calcium; Calcium Radioisotopes; Chickens; Cyclic AMP; Male; Nucleotides, Cyclic; Parathyroid Hormone; Peptide Fragments; Prostaglandins E, Synthetic; Theophylline

1989
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline.
    European journal of pharmacology, 1989, Oct-24, Volume: 170, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Psychomotor Performance; Reinforcement Schedule; Saimiri; Stimulation, Chemical; Theophylline

1989
Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1989, Volume: 94, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Adrenergic beta-Agonists; Animals; Caffeine; Drug Interactions; Epinephrine; Isoproterenol; Lipids; Male; Propranolol; Swine; Theophylline

1989
[Plasma determination of 7 common drugs by high performance liquid chromatography].
    Annales de biologie clinique, 1989, Volume: 47, Issue:2

    Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid

1989
Presence and properties of cAMP phosphodiesterase from promastigote forms of Leishmania tropica and Leishmania donovani.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1989, Volume: 93, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Leishmania donovani; Leishmania tropica; Magnesium; Phenobarbital; Substrate Specificity; Temperature; Theophylline; Trifluoperazine

1989
The influence of structure on the accumulation of caffeine induced by methyl xanthine derivatives.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:2

    Topics: Animals; Caffeine; Male; Rats; Rats, Inbred Strains; Theophylline; Xanthines

1989
Methylxanthines augment the renin response to suprarenal-aortic constriction.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 339, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Aorta; Blood Pressure; Caffeine; Dogs; Hemodynamics; Hypertension, Renovascular; Kidney; Renal Circulation; Renin; Theophylline; Xanthines

1989
Methyl xanthines enhance taste: evidence for modulation of taste by adenosine receptor.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Animals; Caffeine; Female; Humans; In Vitro Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Taste; Theobromine; Theophylline; Xanthines

1985
Methylxanthine effects on caudate dopamine release as measured by in vivo electrochemistry.
    Life sciences, 1989, Volume: 45, Issue:21

    Topics: Anesthesia; Animals; Caffeine; Caudate Nucleus; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Extracellular Space; Male; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline; Urethane; Xanthines

1989
The effect of adenosine and adenosine analogues on methylxanthine-induced hypercalciuria in the rat.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:10

    Topics: Adenosine; Animals; Body Weight; Caffeine; Calcium; Diet; Diuresis; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1989
Non-extraction HPLC method for the simultaneous measurement of theophylline and caffeine in human serum.
    Annals of clinical biochemistry, 1989, Volume: 26 ( Pt 6)

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline; Xanthines

1989
Theophylline does not increase maximal tetanic force or diaphragm endurance in vitro.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 67, Issue:4

    Topics: Animals; Caffeine; Cricetinae; Diaphragm; Electric Stimulation; Male; Mesocricetus; Muscle Contraction; Physical Endurance; Rats; Rats, Inbred Strains; Temperature; Theophylline

1989
[DNA repair and drug resistance: enhancement of the effects of anticancer agents by DNA repair inhibitors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Cell Division; Child; Cisplatin; DNA Repair; Doxorubicin; Drug Resistance; Drug Synergism; Humans; Male; Middle Aged; Osteosarcoma; Pentoxifylline; Theophylline; Tumor Cells, Cultured

1989
The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:2

    Topics: Adult; Aged; Caffeine; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theobromine; Theophylline

1989
Caffeine pharmacokinetics in preterm infants older than 2 weeks.
    Developmental pharmacology and therapeutics, 1989, Volume: 12, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Sleep Apnea Syndromes; Theophylline

1989
Excretion and metabolism of a series of xanthines by the turtle Pseudemys scripta elegans.
    The veterinary quarterly, 1989, Volume: 11, Issue:1

    Topics: Animals; Caffeine; Theobromine; Theophylline; Turtles; Uric Acid; Xanthine; Xanthines

1989
Interaction of caffeine and of theophylline with liver glutamate dehydrogenase.
    Biochemistry international, 1989, Volume: 18, Issue:1

    Topics: Adenosine Diphosphate; Animals; Binding, Competitive; Caffeine; Cattle; Glutamate Dehydrogenase; Kinetics; Liver; Rats; Species Specificity; Theophylline

1989
Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior.
    European journal of pharmacology, 1989, Feb-28, Volume: 161, Issue:2-3

    Topics: Aggression; Animals; Azepines; Caffeine; Clonidine; Dilazep; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Phenylisopropyladenosine; Purines; Theophylline

1989
Comparison of fluorescence polarization immunoassay and HPLC for the determination of theophylline in serum.
    Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Cross Reactions; Fluorescence Polarization; Humans; Immunoassay; Indicators and Reagents; Theophylline

1989
Interaction between oral ciprofloxacin and caffeine in normal volunteers.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:4

    Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Half-Life; Humans; Male; Theophylline

1989
Use of flavor-amplified foods to improve nutritional status in elderly patients.
    Annals of the New York Academy of Sciences, 1989, Volume: 561

    Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Monophosphate; Nutritional Status; Smell; Taste; Theobromine; Theophylline

1989
Caffeine-induced Ca2+ release activates Ca2+ extrusion via Na+-Ca2+ exchanger in cardiac myocytes.
    The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 1

    Topics: Animals; Benzofurans; Caffeine; Calcium; Carrier Proteins; Electric Conductivity; Fluorescent Dyes; Fura-2; Guinea Pigs; Heart; Kinetics; Membrane Potentials; Myocardium; Nickel; Rats; Sodium; Sodium-Calcium Exchanger; Theophylline

1989
Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers.
    The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 2

    Topics: Animals; Caffeine; Calcium; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Glycolysis; Heart Conduction System; Male; Methoxamine; Myocardial Contraction; Norepinephrine; Potassium; Propranolol; Purkinje Fibers; Theophylline

1989
Felodipine reduces the absorption of theophylline in man.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:5

    Topics: Adult; Blood Pressure; Caffeine; Calcium Channel Blockers; Drug Interactions; Felodipine; Humans; Intestinal Absorption; Male; Nitrendipine; Theophylline

1989
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
    Life sciences, 1989, Volume: 45, Issue:8

    Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random Allocation; Seizures; Theophylline; Xanthines

1989
Effects of passive smoking on theophylline clearance.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:4

    Topics: Adult; Caffeine; Cotinine; Diet; Female; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nicotine; Theophylline; Tobacco Smoke Pollution

1989
Involvement of cAMP in initiating maturation of the brittle-star Amphipholis kochii oocytes: induction of oocyte maturation by inhibitors of cyclic nucleotide phosphodiesterase and activators of adenylate cyclase.
    Developmental biology, 1988, Volume: 125, Issue:1

    Topics: Adenylyl Cyclases; Animals; Caffeine; Calmodulin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Hydrogen-Ion Concentration; Oocytes; Radioimmunoassay; Starfish; Theophylline

1988
Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions.
    Molecular pharmacology, 1988, Volume: 33, Issue:5

    Topics: Allosteric Regulation; Animals; Caffeine; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Receptors, GABA-A; Theophylline; Time Factors

1988
The effect of glucose on liver glycogen synthase phosphatase activity in the presence of ATP-Mg.
    Archives of biochemistry and biophysics, 1988, Volume: 264, Issue:1

    Topics: Adenosine Triphosphate; Animals; Caffeine; Drug Stability; Glucose; Glucose-6-Phosphate; Glucosephosphates; Glycogen-Synthase-D Phosphatase; Liver; Magnesium; Male; Phosphoprotein Phosphatases; Protease Inhibitors; Rats; Rats, Inbred Strains; Substrate Specificity; Theophylline

1988
Modification of myofibrillar responsiveness to Ca++ as an inotropic mechanism.
    Circulation, 1986, Volume: 73, Issue:3 Pt 2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aequorin; Animals; Caffeine; Calcium; Cardiotonic Agents; Cats; Cyclic AMP; Dogs; Guinea Pigs; Hydrogen-Ion Concentration; Imidazoles; Muscles; Myocardial Contraction; Myofibrils; Rabbits; Rats; Sarcoplasmic Reticulum; Theophylline; Troponin; Troponin C

1986
Lack of effect of nizatidine on hepatic drug metabolism in man.
    British journal of clinical pharmacology, 1985, Volume: 20, Issue:6

    Topics: Adult; Blood Proteins; Caffeine; Chlordiazepoxide; Histamine H2 Antagonists; Humans; Kinetics; Liver; Lorazepam; Male; Nizatidine; Pharmaceutical Preparations; Protein Binding; Theophylline; Thiazoles

1985
Amphetamine-like effects of anorectics and related compounds in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Amphetamines; Animals; Appetite Depressants; Bupropion; Caffeine; Chlorphentermine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Mazindol; Propiophenones; Propylamines; Theophylline

1987
Changes induced by caffeine, theophylline and theobromine on calcium uptake, respiration and ATP levels in rat-liver mitochondria.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 91, Issue:2

    Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Female; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1988
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1

    Topics: Acetylation; Adult; Allopurinol; Caffeine; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Kidney; Male; Metabolic Clearance Rate; Theophylline

1989
Correlation of caffeine elimination and Child's classification in liver cirrhosis.
    Klinische Wochenschrift, 1989, Jan-04, Volume: 67, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Theobromine; Theophylline

1989
Effect of poly(adenosinediphosphoribose) synthesis inhibitors and structurally related compounds on radiation-induced G2 arrest.
    Radiation research, 1988, Volume: 113, Issue:1

    Topics: Aminobenzoates; Animals; Benzamides; Caffeine; Cell Line; Cricetinae; Deoxyadenosines; Interphase; meta-Aminobenzoates; Niacin; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline

1988
On the mechanism of action of theophylline and caffeine.
    Acta medica Scandinavica, 1985, Volume: 217, Issue:2

    Topics: Adenosine; Asthma; Caffeine; Calcium; Cyclic AMP; Humans; Muscle Contraction; Receptors, Cell Surface; Receptors, Purinergic; Theophylline

1985
Methylxanthine discrimination in the rat: possible benzodiazepine and adenosine mechanisms.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:5

    Topics: Animals; Caffeine; Chlordiazepoxide; Conditioning, Operant; Cues; Discrimination Learning; Male; Papaverine; Pentobarbital; Phenylisopropyladenosine; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; Theophylline

1985
Effect of poly(adenosine diphosphate-ribose) polymerase inhibitors on neocarzinostatin-induced G2 delay in HeLa-S3 cells.
    Cancer research, 1985, Volume: 45, Issue:9

    Topics: Antibiotics, Antineoplastic; Caffeine; Cell Cycle; Cells, Cultured; DNA Repair; HeLa Cells; Humans; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Theophylline; Thymidine; Zinostatin

1985
Effects of caffeine on transport, metabolism and ultrastructure of isolated rat colon.
    General physiology and biophysics, 1985, Volume: 4, Issue:1

    Topics: Animals; Biological Transport, Active; Bucladesine; Butyrates; Caffeine; Colon; Glucose; Intestinal Absorption; Male; Microvilli; Rats; Rats, Inbred Strains; Sodium; Theophylline

1985
A caffeine analogue (1,3,7-trimethyl-6-thioxo-2-oxopurine) with a negative inotropic and chronotropic effect.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 330, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Depression, Chemical; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Muscle Proteins; Myocardial Contraction; Myocardium; Phosphoric Diester Hydrolases; Theophylline; Xanthines

1985
Regulation of energy expenditure in brown adipose tissue.
    International journal of obesity, 1985, Volume: 9 Suppl 2

    Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Body Temperature Regulation; Bucladesine; Caffeine; Cold Temperature; Dose-Response Relationship, Drug; Energy Metabolism; Female; Hyperphagia; Models, Biological; Norepinephrine; Oxygen Consumption; Palmitic Acid; Palmitic Acids; Physical Exertion; Propranolol; Rats; Rats, Inbred Strains; Temperature; Theophylline

1985
Effects of caffeine and 8-phenyltheophylline on the actions of purines and opiates in the guinea-pig ileum.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Adenosine; Animals; Caffeine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Nalorphine; Norepinephrine; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Theophylline

1986
Inhibitory effects of theophylline and dibutyryl cAMP on murine erythroleukemia cell differentiation.
    Biochemical and biophysical research communications, 1986, Jan-29, Volume: 134, Issue:2

    Topics: Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Cyclic AMP; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Synergism; Erythropoiesis; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Theophylline

1986
[Methylxanthines and enzymes which degrade adenine nucleotides].
    Bratislavske lekarske listy, 1986, Volume: 85, Issue:3

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Deaminase; Animals; Brain; Caffeine; Female; Guinea Pigs; Liver; Male; Nucleotidases; Purine-Nucleoside Phosphorylase; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1986
Metabolism of glucose by preimplantation mouse embryos in the presence of glucagon, insulin, epinephrine, cAMP, theophylline and caffeine.
    Australian journal of biological sciences, 1985, Volume: 38, Issue:4

    Topics: Animals; Blastocyst; Caffeine; Carbon Radioisotopes; Cleavage Stage, Ovum; Cyclic AMP; Epinephrine; Female; Glucagon; Glucose; Insulin; Kinetics; Mice; Morula; Organ Culture Techniques; Theophylline

1985
Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism.
    Psychopharmacology, 1988, Volume: 95, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Male; Psychomotor Performance; Receptors, Purinergic; Saimiri; Stimulation, Chemical; Theophylline; Xanthines

1988
[Theophylline-caffeine interaction in bronchial disease patients with cardiac and hepatic failure].
    Presse medicale (Paris, France : 1983), 1985, Jun-15, Volume: 14, Issue:24

    Topics: Adult; Bronchial Diseases; Caffeine; Drug Interactions; Heart Diseases; Humans; Liver Diseases; Theophylline

1985
[Analysis and importance of levels of caffeine and theophylline in cord blood of premature newborn infants].
    Bollettino della Societa italiana di biologia sperimentale, 1988, Volume: 64, Issue:2

    Topics: Caffeine; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Theophylline

1988
Xanthine derivatives: could a further study of the mechanisms of action yield new therapeutic agents?
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:4

    Topics: Caffeine; Humans; Theobromine; Theophylline

1988
Quality control in therapeutic drug monitoring.
    Pharmaceutisch weekblad. Scientific edition, 1988, Aug-19, Volume: 10, Issue:4

    Topics: Caffeine; Flunitrazepam; Gentamicins; Humans; Laboratories; Netherlands; Pharmaceutical Preparations; Quality Control; Reference Values; Theophylline; Thiopental; United States

1988
New methylxanthine thio-derivatives inducing marked tracheal relaxation without increasing cardiac inotropism or motor activity.
    Pharmacological research communications, 1988, Volume: 20, Issue:7

    Topics: Animals; Caffeine; Guinea Pigs; In Vitro Techniques; Mice; Motor Activity; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Theophylline; Trachea

1988
Evaluation of a rapid theophylline test strip assay in the emergency department setting.
    Annals of emergency medicine, 1988, Volume: 17, Issue:10

    Topics: Caffeine; Emergency Service, Hospital; Evaluation Studies as Topic; Humans; Prospective Studies; Reagent Strips; Theophylline

1988
Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes.
    Biochemical pharmacology, 1988, Oct-01, Volume: 37, Issue:19

    Topics: Adult; Age Factors; Animals; Caffeine; Cells, Cultured; Cytochrome P-450 Enzyme System; Female; Humans; Infant, Newborn; Liver; Male; Rats; Rats, Inbred Strains; Species Specificity; Theophylline

1988
Slowing of relaxation in the fatiguing hamster diaphragm is enhanced by theophylline.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3

    Topics: Animals; Caffeine; Calcium; Cricetinae; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contraction; Muscle Relaxation; Theophylline; Verapamil

1988
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs.
    Life sciences, 1988, Volume: 43, Issue:21

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred DBA; Motor Activity; Reference Values; Theobromine; Theophylline

1988
Increases in plasma concentrations of steroids in the rat after the administration of caffeine: comparison with plasma disposition of caffeine.
    The Journal of endocrinology, 1988, Volume: 119, Issue:2

    Topics: Animals; Caffeine; Corticosterone; Liver; Male; Progesterone; Rats; Rats, Inbred Strains; Sodium; Stress, Physiological; Testosterone; Theobromine; Theophylline

1988
The relationship between theophylline, caffeine and heart rate in neonates.
    Annals of clinical biochemistry, 1988, Volume: 25 ( Pt 4)

    Topics: Aminophylline; Apnea; Caffeine; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Theophylline; Xanthines

1988
Caffeine as a potential risk factor for theophylline neurotoxicity.
    Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:9

    Topics: Animals; Blood Proteins; Brain; Caffeine; Dialysis; Injections, Intravenous; Male; Nervous System Diseases; Protein Binding; Rats; Rats, Inbred Strains; Risk Factors; Seizures; Theophylline

1988
[Pharmacokinetics of caffeine and dimethylxanthines in plasma and saliva].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1988, Volume: 108, Issue:7

    Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Models, Biological; Pregnancy; Saliva; Theophylline

1988
[Studies on gas chromatographic quantitative determination and identification of compound tablets of theophylline].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1988, Volume: 23, Issue:11

    Topics: Caffeine; Chromatography, Gas; Drug Combinations; Ephedrine; Phenacetin; Theophylline

1988
Rapid development of functional tolerance to caffeine-induced seizures in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 188, Issue:2

    Topics: Animals; Brain; Caffeine; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobromine; Theophylline

1988
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies.
    Biochemical pharmacology, 1988, May-01, Volume: 37, Issue:9

    Topics: Adult; Benzoflavones; Caffeine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Humans; Immunologic Techniques; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Verapamil

1988
Caffeine disposition in the pregnant rabbit. I. Pharmacokinetics following administration by intravenous bolus and continuous zero-order infusion.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:2

    Topics: Animals; Caffeine; Female; Infusion Pumps; Infusions, Intravenous; Kinetics; Male; Pregnancy; Pregnancy, Animal; Rabbits; Theophylline; Time Factors

1988
Caffeine disposition in the pregnant rabbit. II. Fetal distribution of caffeine and paraxanthine during chronic maternal caffeine administration.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:2

    Topics: Albumins; Amniotic Fluid; Animals; Caffeine; Female; Fetal Proteins; Fetus; Infusions, Intravenous; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Protein Binding; Rabbits; Serum Albumin; Theophylline; Tissue Distribution

1988
Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats.
    Life sciences, 1988, Volume: 42, Issue:24

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dextroamphetamine; Drug Tolerance; Male; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline

1988
Isocratic liquid chromatographic determination of theophylline, acetaminophen, chloramphenicol, caffeine, anticonvulsants, and barbiturates in serum.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:1

    Topics: Acetaminophen; Anticonvulsants; Barbiturates; Caffeine; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Theophylline

1988
Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3

    Topics: Abortion, Veterinary; Animals; Birth Weight; Body Weight; Caffeine; Female; Fetal Death; Macaca fascicularis; Pregnancy; Pregnancy Outcome; Theophylline

1988
Simultaneous ion-pair and partition liquid chromatography of acetaminophen, theophylline and salicylate with application to 500 toxicologic specimens.
    Clinica chimica acta; international journal of clinical chemistry, 1988, Jul-29, Volume: 175, Issue:3

    Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Humans; Salicylates; Spectrophotometry, Ultraviolet; Theophylline

1988
Apnea in infancy: pathophysiology, diagnosis, and treatment.
    New York state journal of medicine, 1986, Volume: 86, Issue:2

    Topics: Aminophylline; Apnea; Caffeine; Chemoreceptor Cells; Home Nursing; Humans; Infant; Infant, Newborn; Monitoring, Physiologic; Pulmonary Gas Exchange; Sudden Infant Death; Theophylline

1986
Contribution of electrostatic and hydrophobic interactions of bitter substances with taste receptor membranes to generation of receptor potentials.
    Biochimica et biophysica acta, 1986, Aug-29, Volume: 888, Issue:1

    Topics: Adsorption; Animals; Caffeine; Cell Line; Electricity; In Vitro Techniques; Membrane Fluidity; Membrane Potentials; Mice; Osmolar Concentration; Quinine; Rana catesbeiana; Solubility; Strychnine; Taste; Taste Buds; Theophylline

1986
A rapid HPLC method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns.
    Annals of clinical biochemistry, 1986, Volume: 23 ( Pt 4)

    Topics: Caffeine; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Fluorescence Polarization; Humans; Immunoassay; Immunoenzyme Techniques; Quality Control; Theophylline

1986
Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture.
    The Journal of nutrition, 1987, Volume: 117, Issue:2

    Topics: Animals; Body Temperature Regulation; Body Weight; Caffeine; Drug Therapy, Combination; Eating; Energy Intake; Energy Metabolism; Ephedrine; Food Deprivation; Male; Obesity; Rats; Rats, Zucker; Theophylline

1987
Methylxanthine treatment of rats reduces 2,5-oligoadenylate synthesis in liver nuclei.
    Journal of toxicology and environmental health, 1987, Volume: 20, Issue:4

    Topics: 2',5'-Oligoadenylate Synthetase; Animals; Caffeine; Cell Nucleus; Liver; Male; Poly I-C; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1987
Effects of N6-(L-phenylisopropyl)adenosine, caffeine, theophylline and rolipram on the acquisition of conditioned responses in the rabbit.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Adenosine; Animals; Caffeine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Phenylisopropyladenosine; Pyrrolidinones; Rabbits; Rolipram; Theophylline

1987
Renal effects of theophylline and caffeine in newborn rabbits.
    Pediatric research, 1987, Volume: 21, Issue:6

    Topics: Animals; Animals, Newborn; Caffeine; Glomerular Filtration Rate; Kidney; Rabbits; Renal Circulation; Theophylline; Vascular Resistance

1987
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
    Teratology, 1987, Volume: 35, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, Nonmammalian; Emetine; Fluorouracil; Hydroxyurea; Theobromine; Theophylline; Xanthines; Xenopus laevis

1987
Reactions of theophylline, theobromine and caffeine with Fenton's reagent--simulation of hepatic metabolism.
    Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:5

    Topics: Caffeine; Hydrogen Peroxide; Hydroxylation; Iron; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Theobromine; Theophylline

1987
Chronic exposure to subcutaneously implanted methylxanthines. Differential elevation of A1-adenosine receptors in mouse cerebellar and cerebral cortical membranes.
    Biochemical pharmacology, 1987, Aug-01, Volume: 36, Issue:15

    Topics: Animals; Caffeine; Cerebellum; Cerebral Cortex; Delayed-Action Preparations; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; Receptors, Purinergic; Theophylline

1987
Effects of maternal caffeine ingestion on the perinatal cerebrum.
    Biology of the neonate, 1987, Volume: 51, Issue:6

    Topics: Animals; Body Weight; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Organ Size; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Theophylline

1987
Therapeutic drug monitoring in a pediatric laboratory.
    Developmental pharmacology and therapeutics, 1987, Volume: 10, Issue:2

    Topics: Anticonvulsants; Caffeine; Child; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Monitoring, Physiologic; Pharmaceutical Preparations; Theophylline

1987
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
    The Journal of nutrition, 1987, Volume: 117, Issue:7

    Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Inbred Strains; Theophylline; Time Factors

1987
Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects.
    Journal of pharmacokinetics and biopharmaceutics, 1987, Volume: 15, Issue:2

    Topics: Animals; Caffeine; Female; Half-Life; Kinetics; Protein Binding; Rabbits; Theophylline; Ultrafiltration

1987
An animal model for the detection of drug-induced inhibition of caffeine metabolism.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:5

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Depression, Chemical; Drug Interactions; Ethanolamines; Female; Male; Models, Biological; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Theophylline

1987
Ion-pair high-performance liquid chromatographic procedure for the quantitative analysis of theophylline in serum samples.
    Journal of chromatography, 1987, Jun-05, Volume: 417, Issue:1

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Immunoassay; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline; Xanthines

1987
Determination of partial and total cohesion parameters of caffeine, theophylline, and methyl p-hydroxybenzoate by gas-solid chromatography.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:5

    Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Chromatography; Mathematics; Parabens; Solubility; Theophylline; Thermodynamics

1987
Evidence that adenosine mediates the depression of spinal dorsal horn neurons induced by peripheral vibration in the cat.
    Neuroscience, 1987, Volume: 22, Issue:2

    Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Caffeine; Cats; Dipyridamole; Injections, Intravenous; Iontophoresis; Naloxone; Neurons; Spinal Cord; Strychnine; Theophylline; Vibration

1987
Pro-convulsant actions of theophylline and caffeine in the hippocampus: implications for the management of temporal lobe epilepsy.
    Brain research, 1987, Nov-17, Volume: 426, Issue:1

    Topics: Animals; Caffeine; Convulsants; Drug Interactions; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline

1987
Agonist interactions at the calcium pools in skinned and unskinned canine tracheal smooth muscle.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:8

    Topics: Acetylcholine; Animals; Caffeine; Calcium; Dogs; Female; Histamine; In Vitro Techniques; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Serotonin; Theophylline; Trachea

1987
Determination of the urinary metabolites of caffeine and theophylline by high-performance liquid chromatography. A comparative study of a direct injection and an ion-pair extraction procedure.
    Journal of chromatography, 1986, Mar-07, Volume: 375, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Theophylline

1986
Infant apnea.
    Pediatric clinics of North America, 1986, Volume: 33, Issue:3

    Topics: Airway Obstruction; Apnea; Bradycardia; Caffeine; Cardiography, Impedance; Home Nursing; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Monitoring, Physiologic; Risk; Sleep; Sudden Infant Death; Theophylline; Xanthines

1986
Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome.
    Pediatrics, 1986, Volume: 77, Issue:6

    Topics: Administration, Oral; Caffeine; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Infant; Monitoring, Physiologic; Posture; Risk; Sudden Infant Death; Theophylline; Time Factors

1986
Inherent differences in sensitivity to methylxanthines among inbred mice.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Resistance; Mice; Mice, Inbred Strains; Motor Activity; Species Specificity; Theobromine; Theophylline; Time Factors; Xanthines

1986
Complex genetic determinants of susceptibility to methylxanthine-induced locomotor activity changes.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Genetics, Behavioral; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Motor Activity; Theophylline; Xanthines

1986
Effects of dietary protein on theophylline pharmacokinetics and caffeine and aminopyrine breath tests.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2

    Topics: Adult; Aminopyrine; Aminopyrine N-Demethylase; Breath Tests; Caffeine; Dietary Proteins; Humans; Infusions, Parenteral; Kinetics; Male; Theophylline

1986
[Effect of theophylline and caffeine on sensory retinal function in the human].
    Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1986, Volume: 83, Issue:3

    Topics: Adolescent; Adult; Caffeine; Humans; Male; Retina; Theophylline; Vision Tests; Visual Perception

1986
The influence of phosphodiesterase inhibitors on ERG and optic nerve response of the cat.
    Investigative ophthalmology & visual science, 1986, Volume: 27, Issue:9

    Topics: Animals; Caffeine; Cats; Dark Adaptation; Electroretinography; Female; Imidazoles; Male; Optic Nerve; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Retina; Theophylline

1986
Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 333, Issue:2

    Topics: Animals; Blood Flow Velocity; Brain; Caffeine; Cerebrovascular Circulation; Glucose; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1986
Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors.
    Neuropharmacology, 1986, Volume: 25, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Theophylline

1986
Changes in theophylline metabolism during postnatal development in rat liver slices.
    Biochemical pharmacology, 1986, Sep-15, Volume: 35, Issue:18

    Topics: Allopurinol; Animals; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Liver; Proadifen; Rats; Theobromine; Theophylline

1986
Effect of chronic exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings.
    Brain research, 1986, Volume: 392, Issue:1-2

    Topics: Animals; Brain; Caffeine; Diazepam; Female; Lactation; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Synaptosomes; Theophylline

1986
Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:2

    Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline

1986
Quantitative assessment of caffeine partial clearances in man.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:2

    Topics: Adult; Caffeine; Humans; Kinetics; Male; Theobromine; Theophylline

1986
Simple and sensitive method for the simultaneous determination of enprofylline, theobromine, paraxanthine, theophylline and caffeine using high-performance liquid chromatography.
    Journal of chromatography, 1986, Aug-02, Volume: 380, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Theobromine; Theophylline; Xanthines

1986
Urinary metabolites of caffeine in pregnant women.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:4

    Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines

1986
Reduction of liver plasma flow by caffeine and theophylline.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:5

    Topics: Adenosine; Adult; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Humans; Indocyanine Green; Kinetics; Liver Circulation; Male; Middle Aged; Norepinephrine; Theophylline

1986
Methylxanthines reduce in vitro human overall platelet metabolism as measured by microcalorimetry.
    Acta medica Scandinavica, 1986, Volume: 220, Issue:2

    Topics: Blood Platelets; Body Temperature Regulation; Caffeine; Calorimetry; Humans; Theophylline; Xanthines

1986
Toxicokinetics of caffeine elimination in an infant.
    Journal of toxicology. Clinical toxicology, 1986, Volume: 24, Issue:5

    Topics: Caffeine; Female; Gas Chromatography-Mass Spectrometry; Glucose; Heart Rate; Humans; Infant; Kinetics; Respiration, Artificial; Theophylline

1986
[Interaction between caffeine and theophylline].
    Medizinische Klinik (Munich, Germany : 1983), 1986, Aug-22, Volume: 81, Issue:17

    Topics: Adult; Caffeine; Drug Interactions; Humans; Injections, Intravenous; Metabolic Clearance Rate; Middle Aged; Theophylline

1986
Elimination of chronically consumed caffeine in the pregnant monkey (Macaca fascicularis).
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Drinking; Eating; Female; Macaca fascicularis; Pregnancy; Pregnancy, Animal; Theophylline; Uric Acid

1986
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
    Teratology, 1986, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Female; Limb Deformities, Congenital; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Pregnancy; Theobromine; Theophylline

1986
Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Adenosine; Blood Pressure; Brain; Caffeine; Heart Rate; Hemodynamics; Receptors, Purinergic; Theophylline

1987
[Peculiarities of drug therapy in childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:11

    Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; Drug Therapy; Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Receptors, Drug; Theophylline; Tissue Distribution

1986
Accumulation of caffeine in healthy volunteers treated with furafylline.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:1

    Topics: Administration, Oral; Adult; Caffeine; Drug Interactions; Drug Tolerance; Female; Humans; Kinetics; Male; Sex Factors; Theophylline

1987
Theophylline and caffeine disposition in the neonatal piglet.
    Developmental pharmacology and therapeutics, 1986, Volume: 9, Issue:6

    Topics: Animals; Animals, Newborn; Caffeine; Kinetics; Swine; Theophylline

1986
Prevention of genetic fa/fa obesity with an ephedrine-methylxanthines thermogenic mixture.
    The American journal of physiology, 1987, Volume: 252, Issue:3 Pt 2

    Topics: Animals; Body Composition; Body Temperature Regulation; Caffeine; Energy Intake; Energy Metabolism; Ephedrine; Food Deprivation; Obesity; Rats; Rats, Inbred Strains; Theophylline

1987
Effects of caffeine and theophylline on the fecundity of four lepidopteran species.
    Experimental biology, 1985, Volume: 44, Issue:2

    Topics: Animals; Bombyx; Caffeine; Fertility; Lepidoptera; Theophylline

1985
[Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk].
    Helvetica paediatrica acta, 1985, Volume: 40, Issue:2-3

    Topics: Caffeine; Female; Fetal Blood; Humans; Infant, Premature; Kinetics; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Theobromine; Theophylline

1985
Fatigue in frog skeletal muscle fibres and effects of methylxanthine derivatives.
    Acta physiologica Scandinavica, 1985, Volume: 124, Issue:1

    Topics: Animals; Caffeine; Diethylstilbestrol; Electric Stimulation; Muscle Contraction; Muscles; Rana temporaria; Theophylline

1985
A survey of caffeine measurements in routine samples submitted for theophylline assay.
    Clinical chemistry, 1985, Volume: 31, Issue:6

    Topics: Caffeine; Chromatography; Humans; Immunologic Techniques; Infant, Newborn; Infant, Premature; Middle Aged; Theophylline

1985
Direct determination of theophylline in serum by fluoroimmunoassay using highly specific antibodies.
    Annals of clinical biochemistry, 1985, Volume: 22 ( Pt 5)

    Topics: Animals; Antibody Specificity; Caffeine; Cross Reactions; Female; Fluorescein; Fluoresceins; Fluorescent Antibody Technique; Humans; Rabbits; Sheep; Theobromine; Theophylline; Xanthines

1985
Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression.
    Cancer genetics and cytogenetics, 1986, Jan-01, Volume: 19, Issue:1-2

    Topics: Acute Disease; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Inversion; Chromosomes, Human, 16-18; DNA Repair; DNA, Neoplasm; Humans; Leukemia; Theophylline; X Chromosome

1986
Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:1

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Coffee; Female; Humans; Male; Tea; Theobromine; Theophylline; Xanthines

1986
Comparison between theophylline analysis by nephelometric inhibition immunoassay and high performance liquid chromatography.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:1

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoassay; Nephelometry and Turbidimetry; Theophylline

1986
Caffeine no longer measurable with theophylline channel of the TDx.
    Clinical chemistry, 1985, Volume: 31, Issue:3

    Topics: Autoanalysis; Caffeine; Cross Reactions; Humans; Theophylline

1985
Discriminative stimulus properties of methylxanthines and their metabolites in rats.
    Life sciences, 1985, Mar-11, Volume: 36, Issue:10

    Topics: Animals; Caffeine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1985
Use of microbore high-performance liquid chromatography for the determination of caffeine, theobromine and theophylline in cocoa.
    Journal of chromatography, 1985, Jan-18, Volume: 318, Issue:2

    Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Theobromine; Theophylline

1985
Prediction of xanthine solubilities using statistical techniques.
    Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:2

    Topics: Caffeine; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Solubility; Solvents; Statistics as Topic; Theobromine; Theophylline; Xanthines

1985
High-performance liquid chromatographic determination of dimethylxanthine metabolites of caffeine in human plasma.
    Journal of chromatography, 1985, Mar-22, Volume: 338, Issue:2

    Topics: Ammonium Sulfate; Caffeine; Chromatography, High Pressure Liquid; Humans; Liver Diseases; Theobromine; Theophylline

1985
[Determination of theophylline and caffeine in blood serum by thin-layer chromatography-densitometry].
    Rinsho byori. The Japanese journal of clinical pathology, 1985, Volume: 33, Issue:2

    Topics: Caffeine; Chromatography, Thin Layer; Densitometry; Evaluation Studies as Topic; Female; Fetal Blood; Humans; Pregnancy; Theophylline

1985
The fate of chronically consumed caffeine in the monkey (Macaca fascicularis).
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:3

    Topics: Animals; Biotransformation; Body Weight; Caffeine; Chromatography, High Pressure Liquid; Eating; Female; Macaca fascicularis; Milk; Theobromine; Theophylline; Time Factors

1985
Theophylline and fibrocystic breast disease.
    The Journal of allergy and clinical immunology, 1985, Volume: 75, Issue:6

    Topics: Adult; Age Factors; Asthma; Caffeine; Estrogens; Female; Fibrocystic Breast Disease; Humans; Menopause; Middle Aged; Pregnancy; Risk; Theophylline; Xanthines

1985
The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:3

    Topics: Administration, Oral; Animals; Caffeine; Female; Injections, Intravenous; Kinetics; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1985
Sensitivity of inbred mice to methylxanthines is not determined by plasma xanthine concentration.
    Neuroscience letters, 1985, May-01, Volume: 56, Issue:1

    Topics: Animals; Body Temperature; Caffeine; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Motor Activity; Species Specificity; Theophylline; Xanthine; Xanthines

1985
HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guarana) and Cola spp. samples.
    Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 1985, Volume: 180, Issue:5

    Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Coffee; Plants; Plants, Medicinal; Theophylline

1985
High performance liquid chromatographic procedure for the simultaneous determination of theophylline, caffeine, and phenobarbital in neonates.
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1985, Volume: 23, Issue:5

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Phenobarbital; Spectrophotometry, Ultraviolet; Theophylline

1985
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine.
    Neuropharmacology, 1985, Volume: 24, Issue:7

    Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline

1985
Improved high-performance liquid chromatographic method for the simultaneous determination of caffeine and its N-demethylated metabolites in plasma using solid-phase extraction.
    Journal of chromatography, 1985, Jul-12, Volume: 342, Issue:1

    Topics: Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Humans; Serum Albumin, Bovine; Theobromine; Theophylline; Xanthines

1985
Studies on methyl-xanthines in intact and hypophysectomised rats: differences in pharmacokinetics and adrenocortical response.
    Life sciences, 1985, Sep-30, Volume: 37, Issue:13

    Topics: Adrenal Cortex; Animals; Blood Proteins; Caffeine; Corticosterone; Half-Life; Hematocrit; Hypophysectomy; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1985
Drug discrimination and cross generalization between two methylxanthines.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:3

    Topics: Amphetamine; Animals; Caffeine; Discrimination, Psychological; Generalization, Psychological; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Theophylline

1985
Caffeine citrate: an alternative to theophylline for apnea in prematurity.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:10

    Topics: Apnea; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Theophylline

1985
Two high-performance liquid chromatographic methods for quantitation of theophylline in plasma.
    Journal of chromatography, 1985, Oct-11, Volume: 343, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

1985
Caffeine interference with the CANAM-theophylline reagent kit.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Caffeine; Cross Reactions; Humans; Reagent Kits, Diagnostic; Theophylline

1985
Caffeine disposition after oral administration to pregnant rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:12

    Topics: Administration, Oral; Amniotic Fluid; Animals; Caffeine; Female; Fetus; Pregnancy; Rats; Theobromine; Theophylline; Time Factors

1985
[Determination of caffeine and dimethylxanthines in biological fluids and tissues by high performance liquid chromatography].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1985, Volume: 105, Issue:9

    Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy; Rats; Theophylline; Tissue Distribution

1985
Correlations between electrical and pharmacological observations during anoxia in the rabbit, in normal and assisted respiration.
    Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:3

    Topics: Amphetamine; Brain; Caffeine; Electroencephalography; Ethylamines; Hypoxia; Meclofenoxate; Methylphenidate; Pentylenetetrazole; Respiration; Respiration, Artificial; Theophylline

1971
Cyclic AMP and immune responses. II. Phosphodiesterase inhibitors as potentiators of polynucleotide effects on antibody formation.
    Journal of immunology (Baltimore, Md. : 1950), 1971, Volume: 107, Issue:4

    Topics: Animals; Antibodies; Antibody Formation; Antibody-Producing Cells; Antigens; Caffeine; Culture Techniques; Cyclic AMP; Erythrocytes; Female; gamma-Globulins; Hemagglutination Tests; Hemolytic Plaque Technique; Mice; Phosphoric Monoester Hydrolases; Poly I-C; Polynucleotides; Sheep; Spleen; Theophylline; Tuberculin

1971
Effect of caffeine and theophylline on Mg ++ -dependent ATPase.
    Archives internationales de physiologie et de biochimie, 1972, Volume: 80, Issue:4

    Topics: Adenosine Triphosphatases; Caffeine; Cyclic AMP; Drug Synergism; Enzyme Activation; Erythrocytes; Humans; Magnesium; Membranes; Oxytocin; Saponins; Theophylline

1972
Synergistic effect of methyl-substituted xanthines and neomycin sulphate on Staphylococcus aureus and Pseudomonas aeruginosa in vitro.
    Lancet (London, England), 1973, May-05, Volume: 1, Issue:7810

    Topics: Caffeine; Drug Resistance, Microbial; Drug Synergism; Neomycin; Pseudomonas aeruginosa; Staphylococcus; Theophylline

1973
Relaxation of catch in a molluscan smooth muscle. I. Effects of drugs which act on the adenyl cyclase system.
    Comparative biochemistry and physiology. A, Comparative physiology, 1972, Oct-01, Volume: 43, Issue:2

    Topics: Acetylcholine; Adenine Nucleotides; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antimetabolites; Azides; Bivalvia; Butyrates; Caffeine; Cyanides; Cyclic AMP; Fluorides; Isoproterenol; Muscle Contraction; Muscle, Smooth; Neuromuscular Nondepolarizing Agents; Nicotinic Acids; Seawater; Serotonin; Temperature; Theophylline; Time Factors

1972
Influence of methylxanthines and local anaesthetics on the metabolism of muscle and associated changes in mitochondrial morphology.
    Chemico-biological interactions, 1973, Volume: 6, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acids; Anesthetics, Local; Animals; Caffeine; Caprylates; Carbon Isotopes; Cyclic AMP; Diaphragm; Epinephrine; In Vitro Techniques; Lactates; Microscopy; Microscopy, Electron; Mitochondria, Muscle; Muscles; Oxygen Consumption; Protein Biosynthesis; Rats; Theophylline; Transfer RNA Aminoacylation; Xanthines

1973
Evaluation of electrical pulses and elevated levels of potassium ions as stimulants of adenosine 3', 5'-monophosphate (cyclic AMP) accumulation in guinea-pig brain.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 186, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Brain; Caffeine; Calcium; Cerebellum; Cerebral Cortex; Cyclic AMP; Diphenhydramine; Electric Stimulation; Electrodes; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Norepinephrine; Phosphodiesterase Inhibitors; Potassium; Prostaglandins; Reserpine; Stimulation, Chemical; Theophylline; Xanthenes

1973
Increased synthesis of adrenomedullary catecholamines induced by caffeine and theophylline.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 281, Issue:2

    Topics: Adrenal Glands; Animals; Caffeine; Cordotomy; Dopamine; Enzyme Induction; Epinephrine; Male; Norepinephrine; Rats; Spinal Cord; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase

1974
Relation of the second messenger system to the electrogenesis and regulation of the contraction in the heart cell membrane of insecta.
    Comparative biochemistry and physiology. A, Comparative physiology, 1974, Sep-01, Volume: 49, Issue:1A

    Topics: Action Potentials; Adenylyl Cyclases; Animals; Bucladesine; Caffeine; Cyclic AMP; Electric Stimulation; Enzyme Activation; Fluorides; Grasshoppers; Heart; Heart Rate; Imidazoles; Microelectrodes; Myocardium; Oscillometry; Phosphodiesterase Inhibitors; Serotonin; Theophylline; Time Factors

1974
Intracellular actions of 5-hydroxytryptamine on the bivalve myocardium. 1. Adenylate and guanylate cyclases.
    The Journal of experimental zoology, 1974, Volume: 190, Issue:1

    Topics: Acetylcholine; Adenylyl Cyclases; Animals; Bivalvia; Bucladesine; Caffeine; Cyclic AMP; Cyclic GMP; Dopamine; Guanylate Cyclase; Heart; Myocardium; Protein Binding; Serotonin; Stimulation, Chemical; Temperature; Theophylline; Tritium

1974
[Studies on the effect of various substances on platelet function with several methods].
    Die Medizinische Welt, 1973, Feb-02, Volume: 24, Issue:5

    Topics: Amphetamine; Anti-Anxiety Agents; Blood Platelets; Caffeine; Chlorpromazine; Debrisoquin; Dibenzazepines; Flurazepam; Guanethidine; Humans; Oxazoles; Papaverine; Phenytoin; Platelet Aggregation; Pyridines; Theophylline

1973
[Management of heart and circulation. 1. Circulatory agents].
    Tierarztliche Praxis, 1973, Volume: 1, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Cardiovascular Diseases; Peptides; Theophylline; Vasoconstrictor Agents

1973
[Action of electric stimulation of the brachial plexus on the potential difference of isolated frog skin].
    Archives internationales de physiologie et de biochimie, 1964, Volume: 72, Issue:4

    Topics: Acetazolamide; Acetylcholine; Animals; Anura; Brachial Plexus; Caffeine; Carbachol; Cell Membrane Permeability; Cocaine; Curare; Dinitrophenols; Electric Stimulation; Epithelial Cells; In Vitro Techniques; Neuromuscular Junction; Norepinephrine; Papaverine; Pilocarpine; Skin; Theophylline

1964
A failure of specific inhibitors to affect survival of Chinese hamster cells exposed to ultra-violet light.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1967, Volume: 13, Issue:4

    Topics: Acridines; Animals; Caffeine; Chloramphenicol; Clone Cells; Cricetinae; Cycloheximide; Dactinomycin; Puromycin; Radiation Effects; Theophylline; Ultraviolet Rays

1967
The methyl xanthines--a new class of goitrogens.
    Endocrinology, 1969, Volume: 85, Issue:3

    Topics: Aminophylline; Animals; Antithyroid Agents; Blood Proteins; Caffeine; Cyclic AMP; Drug Synergism; Goiter; Hypophysectomy; In Vitro Techniques; Iodine; Male; Propylthiouracil; Protein Binding; Rats; Theobromine; Theophylline; Thyroid Gland

1969
The inhibition of allergic reactions by sympathomimetic amines and methylxanthines.
    British journal of pharmacology, 1970, Volume: 39, Issue:1

    Topics: Animals; Antigens; Caffeine; Cyclic AMP; Guinea Pigs; Histamine Release; Humans; Hypersensitivity; Isoproterenol; Lung; Theophylline

1970
Properties of glycogen synthetase in erythrocytes.
    European journal of biochemistry, 1972, Volume: 30, Issue:2

    Topics: Adenosine Triphosphate; Caffeine; Erythrocytes; Galactose; Glucosephosphates; Glucosyltransferases; Glycogen; Glycogen Synthase; Hemolysis; Hexosephosphates; Hot Temperature; Humans; Kinetics; Phosphates; Protein Denaturation; Sulfates; Theophylline; Uridine Diphosphate Sugars

1972
Repression of alkaline phosphatase synthesis by adenine, adenosine and adenine nucleotides in an adenine auxotroph of Bacillus anthracis.
    Acta microbiologica Academiae Scientiarum Hungaricae, 1973, Volume: 20, Issue:3

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Alkaline Phosphatase; Bacillus anthracis; Caffeine; Chlorpromazine; Culture Media; Dinitrophenols; Enzyme Repression; Inosine Nucleotides; Lyases; Mutation; Phosphates; Theophylline

1973
Platelets and clot retraction. Effect of divalent cations and several drugs.
    Thrombosis et diathesis haemorrhagica, 1973, Dec-31, Volume: 30, Issue:3

    Topics: Adenosine Diphosphate; Blood Platelets; Caffeine; Calcium Chloride; Chlorides; Clot Retraction; Edetic Acid; Epinephrine; Ethylenes; Glycols; Magnesium; Manganese; Muscle, Smooth; Norepinephrine; Theophylline; Thrombelastography

1973
A systematic study of variables affecting protein binding of thyroxine and triiodothyronine in serum.
    Scandinavian journal of clinical and laboratory investigation, 1974, Volume: 34, Issue:3

    Topics: Anions; Barbiturates; Buffers; Caffeine; Depression, Chemical; Dialysis; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Methimazole; Osmolar Concentration; Phenytoin; Protein Binding; Salicylates; Temperature; Theophylline; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Ultrafiltration

1974
[Do correlations exist between coffee drinking and myocardial infarction? (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Nov-15, Volume: 116, Issue:46

    Topics: Adolescent; Adult; Aged; Caffeine; Coffee; Female; Food Preferences; Germany, West; Health Surveys; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Tea; Theophylline

1974
Spectrophotometric determination of plasma pyridones in man following nicotinamide administration, with a general note on the quantitative treatment of interfering substances in analytical methods.
    Clinica chimica acta; international journal of clinical chemistry, 1966, Volume: 14, Issue:4

    Topics: Caffeine; Humans; Niacinamide; Pyridones; Spectrophotometry; Theophylline

1966
[Influence of reserpine, propranolol, hexamethonium and adrenalectomy on the chronotropic actions of theophylline and caffeine].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 261, Issue:2

    Topics: Animals; Atrial Function; Caffeine; Depression, Chemical; Heart Atria; Heart Rate; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Propranolol; Rats; Reserpine; Tachycardia; Theophylline

1968
Studies on complexes. 13. Effect of complex formation on drug absorption from alimentary tract. (4).
    Chemical & pharmaceutical bulletin, 1968, Volume: 16, Issue:8

    Topics: Aminosalicylic Acids; Animals; Caffeine; Drug Compounding; Intestinal Absorption; Intestine, Small; Kinetics; Niacinamide; Oxazoles; Pyridazines; Rats; Theophylline

1968
[The participation of endogenous catecholamines in the pharmacological effects of theophylline and caffeine].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2

    Topics: Animals; Caffeine; Catecholamines; Hexamethonium Compounds; Propranolol; Rats; Reserpine; Theophylline

1968
Studies on complexes. XIV. Effect of complex formation on drug absorption from alimentary tract. (5). Enhancing the absorption of certain drugs by complex formation.
    Chemical & pharmaceutical bulletin, 1969, Volume: 17, Issue:5

    Topics: Animals; Antipyrine; Caffeine; Indoles; Intestinal Absorption; Intestine, Small; Niacinamide; Rats; Salicylates; Theophylline

1969
Studies on complexes. XVI. Effect of complex formation on drug absorption from alimentary tract. (6). Some factors affecting complex absorption.
    Chemical & pharmaceutical bulletin, 1969, Volume: 17, Issue:7

    Topics: Aminosalicylic Acids; Animals; Caffeine; Drug Synergism; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Niacinamide; Perfusion; Rats; Stimulation, Chemical; Theophylline

1969
The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 169, Issue:2

    Topics: Adenosine Triphosphatases; Aminophylline; Anesthetics, Local; Animals; Biological Transport, Active; Caffeine; Calcium; Cell Membrane Permeability; Endoplasmic Reticulum; Hot Temperature; Lidocaine; Muscles; Procaine; Rabbits; Tetracaine; Theophylline; Veratrine; Xanthines

1969
[Chronotropic and metabolic effects of theophylline and caffeine in euthyroid, hyperthyroid and athyroid rats].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 264, Issue:3

    Topics: Animals; Caffeine; Fatty Acids, Nonesterified; Hyperthyroidism; Male; Oxygen Consumption; Rats; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyroidectomy

1969
Prevention of the negative chronotropic effect of adenosine by caffeine.
    The Tohoku journal of experimental medicine, 1969, Volume: 99, Issue:3

    Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphatases; Animals; Caffeine; Dogs; Methods; Nucleosides; Sinoatrial Node; Theophylline; Vagotomy

1969
Studies on complexes. XX. Effect of complex formation on drug absorption from alimentary tract.
    Chemical & pharmaceutical bulletin, 1970, Volume: 18, Issue:3

    Topics: Adrenochrome; Animals; Caffeine; Chelating Agents; Gastric Mucosa; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Male; Niacinamide; Rats; Theophylline

1970
[Influence of thyroid gland function on the chronotropic and some metabolic actions of theophylline and caffeine].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 267, Issue:2

    Topics: Adenylyl Cyclases; Adrenal Medulla; Animals; Blood Glucose; Caffeine; Enzyme Activation; Fatty Acids, Nonesterified; Heart Rate; Hyperthyroidism; Hypothyroidism; Male; Oxygen Consumption; Rats; Reserpine; Stimulation, Chemical; Theophylline; Triiodothyronine

1970
Proceedings: Prevention by Ca-antagonistic compounds (verapamil, D 600) of coronary smooth muscle contractures due to treatment with cardiac glycosides.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Animals; Caffeine; Calcium; Cardiac Glycosides; Coronary Vessels; Dipyridamole; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prenylamine; Theophylline; Verapamil

1974
A possible role for the adenylcyclase system in insulin secretion.
    The Journal of clinical investigation, 1967, Volume: 46, Issue:11

    Topics: Adrenocorticotropic Hormone; Animals; Caffeine; Glucagon; Insulin; Isoproterenol; Oxytocin; Phenoxybenzamine; Rats; Sympathomimetics; Theophylline; Thyrotropin; Vasopressins

1967
Comparisons of the effects of Bacillus subtilis protease, type VIII (subtilopeptidase A), and insulin on isolated adipose cells. II. Antilipolytic action.
    The Journal of biological chemistry, 1968, Jan-10, Volume: 243, Issue:1

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bacillus subtilis; Caffeine; Carbon Isotopes; Depression, Chemical; Endopeptidases; Epididymis; Fatty Acids, Nonesterified; Glucose; Glycerol; Insulin; Lipid Metabolism; Male; Norepinephrine; Rats; Spectrophotometry; Stimulation, Chemical; Theophylline

1968
A rapid micro-method for the separation, identification and estimation of the purine bases: caffeine, theobromine and theophylline.
    Journal of chromatography, 1968, Jan-09, Volume: 32, Issue:1

    Topics: Caffeine; Chromatography, Thin Layer; Methods; Silicon Dioxide; Theobromine; Theophylline

1968
Effects of piercidin A on the metabolism of isolated adipose cells.
    Biochemical pharmacology, 1968, Volume: 17, Issue:6

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Caffeine; Carbon Isotopes; Depression, Chemical; Epididymis; Fatty Acids; Fructose; Glucose; Glycerol; Glycogen; Insulin; Lipid Metabolism; Male; Norepinephrine; Oxidation-Reduction; Palmitic Acids; Peptide Hydrolases; Rats; Stimulation, Chemical; Theophylline; Ubiquinone

1968
Effects of avenaciolide on lipolysis and on glucose, amino acid and palmitic acid metabolism in isolated adipose cells.
    Biochemical pharmacology, 1968, Volume: 17, Issue:3

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Antifungal Agents; Aspergillus; Caffeine; Carbon Isotopes; Epididymis; Glucose; Insulin Antagonists; Lactones; Lipid Metabolism; Male; Norepinephrine; Oxidation-Reduction; Palmitic Acids; Rats; Theophylline

1968
Controle of the metabolism and lipolytic effects of cyclic 3',5'-adenosine monophosphate in adipose tissue by insulin, methyl xanthines, and nicotinic acid.
    The Journal of biological chemistry, 1968, Jul-25, Volume: 243, Issue:14

    Topics: Adenine Nucleotides; Adipose Tissue; Animals; Blood Glucose; Caffeine; Cyclic AMP; Depression, Chemical; Diabetes Mellitus, Experimental; Epididymis; Hyperinsulinism; Insulin; Kinetics; Lipid Metabolism; Male; Nicotinic Acids; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline

1968
Antilipolytic acition of valinomycin and nonactin in isolated adipose cells through inhibition of adenyl cyclase.
    Biochemical and biophysical research communications, 1968, Jul-26, Volume: 32, Issue:2

    Topics: Adenine; Adenine Nucleotides; Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Caffeine; Carbon Isotopes; Enzyme Inhibitors; Male; Norepinephrine; Rats; Theophylline; Tyrothricin

1968
Stimulation of glucose utilization and inhibition of lipolysis by polyene antibiotics in isolated adipose cells.
    Archives of biochemistry and biophysics, 1968, Sep-20, Volume: 127, Issue:1

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Alkenes; Animals; Anti-Bacterial Agents; Antifungal Agents; Caffeine; Carbon Isotopes; Depression, Chemical; Drug Synergism; Epididymis; Glucose; Hexoses; Insulin; Lipid Metabolism; Lipoproteins; Male; Membranes; Natamycin; Norepinephrine; Nystatin; Peptide Hydrolases; Phlorhizin; Phospholipases; Puromycin; Rats; Stimulation, Chemical; Theophylline

1968
The interconversion of liver glycogen synthetase a and b in vitro.
    European journal of biochemistry, 1968, Dec-05, Volume: 6, Issue:4

    Topics: Adenosine Triphosphate; Animals; Caffeine; Cyclic AMP; Edetic Acid; Fluorides; Glycogen; In Vitro Techniques; Ligases; Liver; Liver Glycogen; Magnesium; Male; Mice; Phosphates; Prednisolone; Sulfates; Theophylline; Xanthines

1968
[Inhibition of lipolysis in adipose tissue by methylisoxazolcarboxylic acids].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, May-07, Volume: 260, Issue:1

    Topics: Adipose Tissue; Animals; Antimetabolites; Caffeine; Carbon Isotopes; Cyclic AMP; Depression, Chemical; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hypolipidemic Agents; Male; Oxazoles; Phosphoric Monoester Hydrolases; Rats; Theophylline; Triglycerides

1968
Adenyl cyclase activity in the rabbit ovary.
    Endocrinology, 1969, Volume: 84, Issue:5

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Carbon Isotopes; Chorionic Gonadotropin; Chromatography, Thin Layer; Cyclic AMP; Enzymes; Female; Fluorides; Follicle Stimulating Hormone; In Vitro Techniques; Luteinizing Hormone; Methods; Ovary; Phosphoric Monoester Hydrolases; Pregnancy; Pseudopregnancy; Rabbits; Sodium; Stimulation, Chemical; Theophylline; Tritium

1969
A comparison of the in-vitro actions of thyroid-stimulating hormone and cyclic 3',5'-adenosine monophosphate on the mouse thyroid gland.
    The Journal of endocrinology, 1969, Volume: 43, Issue:3

    Topics: Adenine Nucleotides; Animals; Caffeine; Chromatography, Paper; Cyclic AMP; Drug Synergism; In Vitro Techniques; Iodine Isotopes; Mice; Theophylline; Thyroid Gland; Thyrotropin; Tissue Extracts

1969
Studies on the action of insulin in isolated adipose tissue cells. II. 3',5'-Nucleotide phosphodiesterase and antilipolysis.
    Biochimica et biophysica acta, 1969, Sep-02, Volume: 184, Issue:3

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Corynebacterium diphtheriae; Cyclic AMP; Depression, Chemical; Epididymis; Epinephrine; Glucagon; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Insulin; Kinetics; Lipid Metabolism; Male; Membranes; Nicotinic Acids; Nucleotides; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline; Ultrasonics

1969
Proteolysis in thyroid slices: Effects of TSH, dibutyryl cyclic 3', 5'-AMP and prostaglandin E.
    Endocrinology, 1970, Volume: 86, Issue:4

    Topics: Adenine Nucleotides; Animals; Caffeine; Chromatography, Paper; Cyclic AMP; Diiodotyrosine; Dogs; Epinephrine; Fluorides; In Vitro Techniques; Iodine; Iodine Isotopes; Iodoproteins; Male; Monoiodotyrosine; Prostaglandins; Proteins; Stimulation, Chemical; Theophylline; Thyroid Gland; Thyrotropin

1970
Dissociation of lipolysis and protein anabolism by ACTH, bovine growth hormone, and thyroid stimulating hormone in adipose tissue with dibutyryl cyclic AMP and theophylline.
    Biochimica et biophysica acta, 1970, Feb-24, Volume: 201, Issue:2

    Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Amino Acids; Animals; Butyrates; Caffeine; Carbon Isotopes; Cyclic AMP; Epididymis; Glycerol; Growth Hormone; Histidine; Lipid Metabolism; Male; Metabolism; Protein Biosynthesis; Rats; Theophylline; Thyrotropin

1970
Regulation of skeletal muscle phosphorylase phosphatase activity. I. Kinetic properties of the active and inactive forms.
    Biochimica et biophysica acta, 1970, Mar-18, Volume: 198, Issue:3

    Topics: Adenine Nucleotides; Animals; Caffeine; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Diphosphates; Enzyme Activation; Glucosyltransferases; Guanine Nucleotides; Hydrogen-Ion Concentration; Kinetics; Muscles; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Rabbits; Theophylline; Uracil Nucleotides

1970
The metabolism of adenosine 3',5'-cyclic phosphate. II. Some properties of adenosine-3',5'-cyclic-phosphate phosphodiesterase from the rat kidney.
    Biochimica et biophysica acta, 1970, Mar-19, Volume: 204, Issue:1

    Topics: 1-Propanol; Adenosine Triphosphate; Alcohols; Animals; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Paper; Cyclic AMP; Fluorides; Hydrogen-Ion Concentration; Kidney; Kinetics; Magnesium; Nucleotides; Phosphoric Monoester Hydrolases; Quaternary Ammonium Compounds; Rats; Solvents; Theophylline; Water; Xanthines

1970
The stimulatory effect of luteinizing hormone on adenyl cyclase in the bovine corpus luteum.
    The Journal of biological chemistry, 1970, Apr-10, Volume: 245, Issue:7

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Caffeine; Carbon Isotopes; Cattle; Corpus Luteum; Cyclic AMP; Depression, Chemical; Enzymes; Epinephrine; Female; Fluorides; Glucagon; Hydrogen Peroxide; Luteinizing Hormone; Metabolism; Phosphoric Monoester Hydrolases; Pregnancy; Prolactin; Serum Albumin, Bovine; Stimulation, Chemical; Theophylline; Time Factors; Tritium

1970
[Antagonism of circulation effect of adenosine by theophylline].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:3

    Topics: Adenine Nucleotides; Aminophylline; Animals; Arteries; Blood Circulation; Blood Platelets; Blood Pressure; Bradycardia; Caffeine; Cell Aggregation; Coronary Vessels; Cyclic AMP; Depression, Chemical; Dogs; Guinea Pigs; Heart Arrest; Heart Rate; In Vitro Techniques; Nucleosides; Rabbits; Rats; Regional Blood Flow; Stimulation, Chemical; Theophylline; Vasodilator Agents

1970
[Hormone sensitive lipase].
    Nihon Naibunpi Gakkai zasshi, 1970, May-20, Volume: 46, Issue:2

    Topics: Adenine Nucleotides; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Enzyme Activation; Epididymis; Epinephrine; Fasting; Growth Hormone; Heparin; Hydrogen-Ion Concentration; In Vitro Techniques; Lipase; Lipoprotein Lipase; Male; Norepinephrine; Rats; Reserpine; Theophylline

1970
The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands.
    The Journal of experimental biology, 1970, Volume: 53, Issue:1

    Topics: Animals; Caffeine; Cyclic AMP; Diptera; Salivary Glands; Serotonin; Theophylline

1970
Adenosine 3',5'-monophosphate phosphodiesterase in the growth medium of Physarum polycephalum.
    Science (New York, N.Y.), 1971, Feb-05, Volume: 171, Issue:3970

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Caffeine; Chromatography, Paper; Culture Media; Hydrogen-Ion Concentration; Kinetics; Myxomycetes; Phosphoric Monoester Hydrolases; Theophylline

1971
Adenosine 3',5'-cyclic phosphate phosphodiesterase of corpus luteum.
    Biochimica et biophysica acta, 1971, Feb-10, Volume: 227, Issue:2

    Topics: Animals; Caffeine; Cattle; Corpus Luteum; Cyclic AMP; Estrus; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Phosphoric Monoester Hydrolases; Pregnancy; Rats; Theophylline

1971
Sodium and water movement across the urinary bladder of a urodele amphibian (th mudpuppy Necturus maculosus): studies and vasotocin and aldosterone.
    General and comparative endocrinology, 1971, Volume: 16, Issue:2

    Topics: Aldosterone; Amphotericin B; Animals; Anura; Biological Transport; Caffeine; Cyclic AMP; Diuretics; In Vitro Techniques; Membrane Potentials; Ouabain; Peptides; Physiology, Comparative; Pituitary Hormones, Posterior; Pyrazines; Seasons; Sodium; Theophylline; Urinary Bladder; Urodela; Vasotocin; Water

1971
ACTH secretion due to hypothalamo-pituitary effects of adenosine 3',5'-monophosphate and related substances.
    Endocrinology, 1971, Volume: 89, Issue:2

    Topics: Adenine Nucleotides; Adrenocorticotropic Hormone; Animals; Caffeine; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP; Dexamethasone; Female; Hypothalamo-Hypophyseal System; Pituitary Gland; Rats; Stimulation, Chemical; Theophylline

1971
Uptake and release of 45Ca by brain microsomes, synaptosomes and synaptic vesicles.
    Journal of neurochemistry, 1971, Volume: 18, Issue:8

    Topics: Adenosine Monophosphate; Adenosine Triphosphatases; Animals; Axons; Biological Transport, Active; Brain; Caffeine; Calcium; Calcium Isotopes; Cell Membrane; Choline; Cyclic AMP; In Vitro Techniques; Magnesium; Microsomes; Mitochondria; Potassium Chloride; Rats; Sodium Chloride; Sucrose; Synaptic Vesicles; Theophylline; Xanthines

1971
Effects of phosphodiesterase inhibitors on cyclic AMP levels and on lipolysis.
    Annals of the New York Academy of Sciences, 1971, Dec-30, Volume: 185

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Depression, Chemical; In Vitro Techniques; Lipid Metabolism; Lipid Mobilization; Liver; Myocardium; Papaverine; Phosphoric Monoester Hydrolases; Rats; Stimulation, Chemical; Theophylline; Xanthines

1971
On the role of cyclic AMP in insulin release: I. Overall effects in cultured fetal rat pancreas.
    Annals of the New York Academy of Sciences, 1971, Dec-30, Volume: 185

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Caffeine; Calcium; Cyclic AMP; Fetus; Glucose; Hexoses; Insulin; Insulin Secretion; Islets of Langerhans; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pyruvates; Rats; Theophylline; Tolbutamide

1971
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans.
    The Biochemical journal, 1971, Volume: 122, Issue:1

    Topics: Animals; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Theophylline; Xanthines

1971
Antibody formation: reduced responses after administration of excessive amounts of nonspecific stimulators.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:6

    Topics: Animals; Antibody Formation; Antigens; Caffeine; Cells, Cultured; Cyclic AMP; Erythrocytes; Injections, Intraperitoneal; Injections, Intravenous; Mice; Polynucleotides; Sheep; Spleen; Stimulation, Chemical; Theophylline

1971
Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines.
    The Journal of biological chemistry, 1971, Oct-25, Volume: 246, Issue:20

    Topics: Animals; Caffeine; Calcium; Carbon Isotopes; Cattle; Cholecystokinin; Cyclic AMP; Drug Synergism; Epinephrine; Fasting; Fluorides; Glucagon; Gluconeogenesis; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; Isoproterenol; Kinetics; Lactates; Liver; Male; Nicotinic Acids; Norepinephrine; Perfusion; Prostaglandins; Rats; Rats, Inbred Strains; Secretin; Serotonin; Theophylline

1971
The determination of nikethamide and other compounds in pharmaceutical dosage forms by thin-layer chromatography.
    The Analyst, 1971, Volume: 96, Issue:147

    Topics: Adenosine; Caffeine; Chromatography, Thin Layer; Dosage Forms; Gels; Methods; Niacinamide; Silicon Dioxide; Solvents; Spectrophotometry; Strychnine; Theophylline; Ultraviolet Rays

1971
The effect of dihydroergotamine on the phosphodiesterase activity of cat grey matter.
    Experientia, 1971, Volume: 27, Issue:11

    Topics: Animals; Brain; Caffeine; Cats; Chromatography; Cyclic AMP; Ergotamine; Papaverine; Phosphoric Monoester Hydrolases; Theophylline

1971
Cyclic nucleotide phosphodiesterase: high activity in a mammalian photoreceptor.
    Science (New York, N.Y.), 1972, Feb-18, Volume: 175, Issue:4023

    Topics: Animals; Brain; Butyrates; Caffeine; Cattle; Centrifugation, Density Gradient; Chickens; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Hydrolysis; Kinetics; Papaverine; Phosphoric Monoester Hydrolases; Photoreceptor Cells; Rats; Retina; Theophylline; Uracil Nucleotides

1972
Role of cyclic 3',5'-amp in the action of physiological secretagogues on the metabolism of rat pancreas in vitro.
    Biochimica et biophysica acta, 1971, Volume: 252, Issue:1

    Topics: Animals; Butyrates; Caffeine; Carbamates; Carbon Isotopes; Cholecystokinin; Choline; Chymotrypsinogen; Cyclic AMP; Glucose; In Vitro Techniques; Lactates; Leucine; Lipase; Pancreas; Phosphates; Phosphatidylinositols; Phospholipids; Phosphorus Isotopes; Protein Biosynthesis; Rats; Theophylline; Tritium

1971
The effect of cyclic adenosine 3',5' monophosphate, methyl xanthines and nicotinic acid on plasma nonesterified fatty acids in sheep.
    Acta veterinaria Scandinavica, 1971, Volume: 12, Issue:4

    Topics: Animals; Blood Glucose; Caffeine; Cyclic AMP; Fatty Acids, Nonesterified; Female; Glycogen Storage Disease; Glycolysis; Injections, Intravenous; Nicotinic Acids; Sheep; Theophylline

1971
The stimulating action of gastrin pentapeptide and histamine on adenyl cyclase activity in rat stomach.
    Experientia, 1971, Dec-15, Volume: 27, Issue:12

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Autoradiography; Caffeine; Carbon Isotopes; Cyclic AMP; Enzyme Activation; Gastrins; Histamine; Male; Peptides; Rats; Stimulation, Chemical; Stomach; Theophylline

1971
Comparison of the phosphodiesterases in the submaxillary gland, brain and liver.
    British journal of pharmacology, 1972, Volume: 45, Issue:1

    Topics: Animals; Brain; Caffeine; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Liver; Papaverine; Phosphoric Monoester Hydrolases; Submandibular Gland; Theophylline

1972
Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.
    The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2

    Topics: Adenine; Caffeine; Cyclic AMP; Epinephrine; Guanine; Guanosine; Humans; Hypoxanthines; Imidazoles; Leukocytes; Movement; Purines; Pyrimidines; Reserpine; Structure-Activity Relationship; Theophylline; Thymine; Uracil; Uric Acid; Xanthines

1972
[Action of phosphodiesterase inhibitors on electric discharge of the electroplax isolated from Electrophorus electricus (L.)].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1972, Feb-28, Volume: 274, Issue:9

    Topics: Action Potentials; Animals; Caffeine; Cyclic AMP; Electric Organ; Electric Stimulation; Fishes; Phosphoric Monoester Hydrolases; Theophylline; Time Factors

1972
The actions of dibutyryl cyclic adenosine 3',5'-monophosphate and methyl xanthines on pancreatic exocrine secretion.
    The Journal of physiology, 1972, Volume: 223, Issue:3

    Topics: Animals; Caffeine; Cats; Cholecystokinin; Cyclic AMP; Drug Synergism; In Vitro Techniques; Pancreas; Pancreatic Juice; Secretin; Stimulation, Chemical; Theobromine; Theophylline; Water; Xanthines

1972
[Inhibition of adenyl cyclase preparations from rat kidney by calcium ions and various diuretics].
    Naunyn-Schmiedeberg's archives of pharmacology, 1972, Volume: 273, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Animals; Caffeine; Calcitonin; Calcium; Carbon Isotopes; Cyclic AMP; Depression, Chemical; Dithiothreitol; Diuretics; Ethacrynic Acid; In Vitro Techniques; Kidney; Magnesium; Male; Manganese; Organomercury Compounds; Parathyroid Hormone; Rats; Theophylline; Vasopressins

1972
[Demonstration of 3'5'-cyclic AMP phosphodiesterase activity in the human placenta at term].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1972, Jun-12, Volume: 274, Issue:24

    Topics: Caffeine; Cyclic AMP; Epinephrine; Female; Fluorides; Humans; Imidazoles; Luteinizing Hormone; Norepinephrine; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Placenta; Pregnancy; Sodium; Theophylline; Time Factors; Tritium

1972
Cyclic 3',5'-AMP phosphodiesterase in isolated fat cells. Simple and sensitive methods for the assay of phosphodiesterase activity in fat cells and studies of the enzyme inhibition by theophylline.
    Pharmacology, 1972, Volume: 7, Issue:2

    Topics: Adipose Tissue; Animals; Brain; Caffeine; Chromatography, Ion Exchange; Cyclic AMP; Kinetics; Male; Methods; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Rats; Spectrophotometry; Theophylline; Time Factors

1972
Cyclic 3',5'-AMP phosphodiesterase of human blood lymphocytes.
    Biochimica et biophysica acta, 1972, Aug-28, Volume: 276, Issue:2

    Topics: Caffeine; Calcium; Chloromercuribenzoates; Cold Temperature; Cyclic AMP; Dithiothreitol; Drug Stability; Endotoxins; Humans; Hydrogen-Ion Concentration; Kinetics; Lectins; Lipopolysaccharides; Lymphocytes; Magnesium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Salmonella typhi; Streptolysins; Subcellular Fractions; Theophylline; Time Factors

1972
Cyclic-AMP in the aqueous humor: the effects of adrenergic agents.
    Experimental eye research, 1972, Volume: 14, Issue:3

    Topics: Aminophylline; Animals; Aqueous Humor; Caffeine; Ciliary Body; Cornea; Cyclic AMP; Epinephrine; Intraocular Pressure; Iris; Isoproterenol; Male; Norepinephrine; Phenoxybenzamine; Propranolol; Rabbits; Retina; Stimulation, Chemical; Sympatholytics; Sympathomimetics; Theophylline

1972
Calcium current channels induced by catecholamines in chick embryonic hearts whose fast sodium channels are blocked by tetrodotoxin or elevated potassium.
    Circulation research, 1972, Volume: 31, Issue:6

    Topics: Acetylcholine; Age Factors; Animals; Caffeine; Calcium; Catecholamines; Chick Embryo; Cyclic AMP; Epinephrine; Heart; In Vitro Techniques; Isoproterenol; Lanthanum; Microelectrodes; Myocardium; Norepinephrine; Phenylalanine; Potassium; Prostaglandins; Sodium; Structure-Activity Relationship; Tetrodotoxin; Theophylline; Time Factors

1972
The development of lipolytic sensitivity in the isolated fat cells of Gallus domesticus during the foetal and neonatal period.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1972, Nov-15, Volume: 43, Issue:3

    Topics: Adipose Tissue; Age Factors; Animals; Animals, Newborn; Caffeine; Chick Embryo; Chickens; Cyclic AMP; Drug Interactions; Glucagon; Lipid Metabolism; Norepinephrine; Phosphoric Diester Hydrolases; Theophylline

1972
[Role of cyclic AMP in neuromuscular transmission--with special reference to the effect of catecholamines, xanthines and calcium on myasthenic syndrome].
    Rinsho shinkeigaku = Clinical neurology, 1972, Volume: 12, Issue:10

    Topics: Caffeine; Calcium; Catecholamines; Cyclic AMP; Depression, Chemical; Epinephrine; Evoked Potentials; Humans; Myasthenia Gravis; Neuromuscular Junction; Synaptic Transmission; Theophylline; Xanthines

1972
1-Ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)--a potent new inhibitor of cyclic 3',5'-nucleotide phosphodiesterases.
    Biochemical pharmacology, 1972, Sep-15, Volume: 21, Issue:18

    Topics: Adrenal Glands; Ammonium Sulfate; Animals; Brain; Caffeine; Carboxylic Acids; Cats; Cattle; Cyclic AMP; Cyclic GMP; Esters; Hydrazines; Hydrolysis; In Vitro Techniques; Kinetics; Male; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Rats; Theophylline

1972
Adenine nucleotide mediation of fructolysis and motility in bovine epididymal spermatozoa.
    The Journal of biological chemistry, 1973, Feb-25, Volume: 248, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Butyrates; Caffeine; Carbon Isotopes; Cattle; Cell Movement; Cyclic AMP; Epididymis; Fructose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; In Vitro Techniques; Kinetics; Lactates; Male; Microscopy, Phase-Contrast; Nucleotides; Phosphodiesterase Inhibitors; Spermatozoa; Theophylline

1973
Metabolism of adenosine 3',5'-cyclic monophosphate and induction of fruiting bodies in Coprinus macrorhizus.
    Journal of bacteriology, 1973, Volume: 113, Issue:3

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclases; Basidiomycota; Caffeine; Cell-Free System; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic AMP; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spores, Fungal; Theophylline; Tritium

1973
Cyclic adenosine 3',5'-monophosphate in the control of melanoma cell replication and differentiation.
    Journal of the National Cancer Institute, 1973, Volume: 50, Issue:2

    Topics: Caffeine; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Dendrites; In Vitro Techniques; Melanins; Melanoma; Methods; Theophylline

1973
Studies on phosphodiesterase from oxyntic cells of bullfrog gastric mucosa. I. Intracellular localization, partial purification, and properties.
    Archives of biochemistry and biophysics, 1973, Volume: 155, Issue:1

    Topics: Ammonium Sulfate; Animals; Anura; Caffeine; Chemical Phenomena; Chemistry; Choline; Cyclic AMP; Gastric Mucosa; Histamine; Hydrogen-Ion Concentration; Imipramine; In Vitro Techniques; Kinetics; Magnesium; Pentagastrin; Phosphoric Diester Hydrolases; Rana catesbeiana; Sulfhydryl Compounds; Theophylline; Time Factors; Tritium

1973
Inhibition of cyclic 3',5'-nucleotide phosphodiesterase in bovine taste papillae by bitter taste stimuli.
    FEBS letters, 1972, Nov-01, Volume: 27, Issue:2

    Topics: Animals; Bacitracin; Binding, Competitive; Caffeine; Cattle; Cyclic AMP; Epithelium; In Vitro Techniques; Kinetics; Papaverine; Phosphodiesterase Inhibitors; Quinine; Strychnine; Taste; Taste Buds; Theobromine; Theophylline

1972
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
    The Biochemical journal, 1973, Volume: 134, Issue:1

    Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol

1973
Cyclic AMP inhibition of cytotoxin ("lymphotoxin") elaboration by stimulated lymphocytes.
    Cellular immunology, 1973, Volume: 8, Issue:2

    Topics: Butyrates; Caffeine; Cells, Cultured; Chromium Isotopes; Cyclic AMP; Cytotoxicity Tests, Immunologic; Humans; L Cells; Lectins; Lymphocytes; Theophylline

1973
Inhibition and enhancement of the noradrenaline constrictor response by methylxanthines.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:7

    Topics: Animals; Caffeine; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Theobromine; Theophylline

1973
Cyclic 3',5'-AMP phosphodiesterase of Neurospora crassa.
    Biochemical and biophysical research communications, 1973, Aug-06, Volume: 53, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Caffeine; Cations, Divalent; Chromatography, Paper; Cyclic AMP; Edetic Acid; Histamine; Imidazoles; Kinetics; Neurospora; Neurospora crassa; Phosphates; Phosphoric Diester Hydrolases; Solubility; Theobromine; Theophylline; Time Factors; Tritium

1973
Action of propranolol on lipolysis induced by catecholamine, dibutyryl cyclic AMP and serum.
    Biochemical pharmacology, 1973, Sep-01, Volume: 22, Issue:17

    Topics: Adipose Tissue; Animals; Bucladesine; Caffeine; Catecholamines; Cells; Epinephrine; Immune Sera; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Propranolol; Rats; Theophylline

1973
Cyclic nucleotide phosphodiesterase from Tetrahymena.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1973, Sep-15, Volume: 46, Issue:1

    Topics: Animals; Caffeine; Chromatography, Gel; Cyclic AMP; Drug Stability; Enzyme Activation; Imidazoles; Isoenzymes; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Tetrahymena; Theophylline; Time Factors; Tritium

1973
Evidence for separate sites of action for the antilipolytic effects of insulin and prostaglandin E1.
    Endocrinology, 1973, Volume: 93, Issue:6

    Topics: Adipose Tissue; Animals; Bucladesine; Caffeine; Cyclic AMP; Insulin; Lipid Mobilization; Male; Phosphoric Diester Hydrolases; Prostaglandins; Rats; Theophylline

1973
[Treatment and surveillance of severe chronic respiratory insufficiency].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1973, Jun-20, Volume: 49, Issue:29

    Topics: Anti-Bacterial Agents; Breathing Exercises; Bronchodilator Agents; Caffeine; Chronic Disease; Expectorants; Glucocorticoids; Humans; Kyphosis; Lung Diseases, Obstructive; Oxygen Inhalation Therapy; Pneumoconiosis; Respiration, Artificial; Respiratory Insufficiency; Scoliosis; Theophylline

1973
Effect of cyclic AMP, theophylline and caffeine on the glucose repression of sporulation in Saccharomyces cerevisiae.
    Archiv fur Mikrobiologie, 1973, Oct-04, Volume: 93, Issue:1

    Topics: Caffeine; Culture Media; Cyclic AMP; Drug Synergism; Glucose; Reproduction; Saccharomyces cerevisiae; Spectrophotometry; Spores, Fungal; Theophylline; Time Factors

1973
Characteristics of cyclic 3',5'-nucleotide phosphodiesterase from the brain of the Madagascar cockroach (Gromphadorhina portentosa).
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1974, Jan-15, Volume: 47, Issue:1

    Topics: Adenosine Triphosphate; Animals; Brain; Caffeine; Cations, Divalent; Citrates; Cockroaches; Colorimetry; Cyclic AMP; Cyclic GMP; Diphosphates; Drug Stability; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnesium; Organ Specificity; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Reserpine; Temperature; Theophylline; Time Factors; Tritium; Xanthines

1974
The effect of cytochalasin B on pigment dispersion and aggregation in perfused Xenopus laevis tailfin melanophores.
    Journal of cellular physiology, 1974, Volume: 83, Issue:1

    Topics: Animals; Bucladesine; Caffeine; Cell Aggregation; Chromatophores; Colchicine; Cyclic AMP; Cytochalasin B; Dimethyl Sulfoxide; Griseofulvin; Histocytochemistry; Larva; Melanins; Microtubules; Phosphodiesterase Inhibitors; Theophylline; Xenopus

1974
Cyclic adenosine 3':5'-monophosphate and protein kinase levels in developing bovine spermatozoa.
    Journal of reproduction and fertility, 1974, Volume: 37, Issue:1

    Topics: Animals; Caffeine; Cattle; Cell Movement; Cyclic AMP; Epididymis; Male; Protein Kinases; Spermatogenesis; Spermatozoa; Theophylline

1974
The mechanism of frog skin lightening by acetylcholine.
    General and comparative endocrinology, 1974, Volume: 23, Issue:1

    Topics: Acetylcholine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Anura; Caffeine; Cyclic AMP; In Vitro Techniques; Isoproterenol; Melanocyte-Stimulating Hormones; Melanocytes; Rana pipiens; Skin; Theophylline; Time Factors

1974
ALA synthetase induction. Inhibitory effect exerted by administration of dibutyryl adenosine-3',5'-cyclic monophosphate, theophylline and caffeine.
    Enzyme, 1973, Volume: 16, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Adenosine Monophosphate; Animals; Bucladesine; Caffeine; Cyclic AMP; Depression, Chemical; Enzyme Induction; Female; Levulinic Acids; Liver; Rats; Theophylline; Time Factors

1973
Cyclic AMP and platelet aggregation.
    Acta Universitatis Carolinae. Medica. Monographia, 1972, Volume: 53

    Topics: Adenosine Diphosphate; Caffeine; Collagen; Cyclic AMP; Densitometry; Depression, Chemical; Epinephrine; Glucagon; Humans; Imidazoles; In Vitro Techniques; Papaverine; Platelet Adhesiveness; Prostaglandins; Theophylline

1972
Modulation by cyclic AMP in vitro of liver plasma membrane (Na+--K+)-ATPase and protein kinases.
    Biochimica et biophysica acta, 1974, Apr-22, Volume: 343, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Bucladesine; Butyrates; Caffeine; Cell Membrane; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Cytosol; Epinephrine; Kinetics; Liver; Magnesium; Male; Nucleotides, Cyclic; Potassium; Propranolol; Protein Kinases; Sodium; Theophylline

1974
Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii.
    Biochimica et biophysica acta, 1974, Apr-25, Volume: 341, Issue:2

    Topics: Aminophylline; Bucladesine; Caffeine; Cations, Divalent; Chlamydomonas; Chromatography, Thin Layer; Cyclic AMP; Cyclic GMP; Diphosphates; Drug Stability; Edetic Acid; Enzyme Activation; Hydrogen-Ion Concentration; Inosine Nucleotides; Kinetics; Nucleotides, Cyclic; Phosphates; Phosphoric Diester Hydrolases; Sulfhydryl Reagents; Temperature; Theophylline; Thymine Nucleotides; Time Factors; Tritium; Uracil Nucleotides

1974
Effect of cyclic AMP, caffeine and theophylline on differentiation of lens epithelial cells.
    Nature, 1974, Jun-21, Volume: 249, Issue:459

    Topics: Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Division; Cells, Cultured; Clone Cells; Crystallins; Drug Synergism; Lens, Crystalline; Rats; Stimulation, Chemical; Theophylline

1974
Inhibition of 2-deoxy-D-glucose transport by theophylline, caffeine and papaverine in alveolar macrophages.
    Biochemical pharmacology, 1974, Jun-15, Volume: 23, Issue:12

    Topics: Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Kinetics; Macrophages; Papaverine; Prostaglandins; Pulmonary Alveoli; Sucrose; Theophylline; Tritium

1974
Rod outer segment phosphodiesterase: factors affecting the hydrolysis of cyclic-AMP and cyclic-GMP.
    Experimental eye research, 1974, Volume: 18, Issue:6

    Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Cattle; Cyclic AMP; Cyclic GMP; Dark Adaptation; Enzyme Activation; Freezing; Hot Temperature; Hydrolysis; In Vitro Techniques; Light; Magnesium; Manganese; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Photoreceptor Cells; Surface-Active Agents; Theophylline; Ultrasonics

1974
Stimulation of sodium transport in turkey erythrocytes by cyclic 3',5'-AMP.
    Endocrinology, 1974, Volume: 95, Issue:2

    Topics: Adenylyl Cyclases; Animals; Biological Transport, Active; Bucladesine; Caffeine; Cell Membrane; Cyclic AMP; Enzyme Activation; Erythrocytes; Isoproterenol; Phosphoric Diester Hydrolases; Propranolol; Sodium; Theophylline; Time Factors; Tritium; Turkeys; Xanthines

1974
The aggregation of rabbit polymorphonuclear leucocytes: effects of antimitotic agents, cyclic nucleotides and methyl xanthines.
    Journal of cell science, 1974, Volume: 16, Issue:1

    Topics: Adenine; Adenosine; Animals; Bucladesine; Caffeine; Cell Aggregation; Colchicine; Cyclic AMP; Cyclic GMP; Depression, Chemical; In Vitro Techniques; Leukocytes; Nucleotides, Cyclic; Rabbits; Stimulation, Chemical; Theobromine; Theophylline; Vinblastine; Xanthines

1974
Cyclic nucleotide phosphodiesterase in silkworm: purification and properties.
    Biochimica et biophysica acta, 1974, Nov-25, Volume: 370, Issue:1

    Topics: Animals; Bombyx; Caffeine; Cations, Divalent; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Edetic Acid; Electrophoresis, Disc; Fluorides; Hydrogen-Ion Concentration; Hydroxyapatites; Imidazoles; Kinetics; Larva; Molecular Weight; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature; Theophylline

1974
Studies on lipolysis in lipid micelles isolated from adipose tissue.
    Journal of biochemistry, 1974, Volume: 75, Issue:6

    Topics: Adenosine; Adenosine Monophosphate; Adipose Tissue; Animals; Bucladesine; Caffeine; Colloids; Cyclic AMP; Epididymis; Epinephrine; In Vitro Techniques; Lipid Metabolism; Macromolecular Substances; Male; Phospholipases; Rats; Theophylline

1974
In vitro response of goldfish (Carassius auratus L.) dermal melanophores to cyclic 3',5'-nucleotides, nucleoside 5'-phosphates and methylxanthines.
    Journal of cellular physiology, 1974, Volume: 84, Issue:2

    Topics: Adenosine Monophosphate; Animals; Binding, Competitive; Bucladesine; Caffeine; Chromatophores; Cyclic AMP; Cyclic GMP; Cyprinidae; Cytosine Nucleotides; Goldfish; Guanine Nucleotides; Melanophores; Nucleotides; Nucleotides, Cyclic; Skin; Theophylline; Thymine Nucleotides; Time Factors; Uracil Nucleotides

1974
Structure-activity relations for caffeine: a comparative study of the inotropic effects of the methylxanthines, imidazoles and related compounds on the frog's heart.
    The Journal of physiology, 1974, Volume: 242, Issue:3

    Topics: Adenosine; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Heart; Heart Atria; Histamine; Histidine; Hydrogen-Ion Concentration; Hypoxanthines; Imidazoles; In Vitro Techniques; Naphazoline; Phentolamine; Pilocarpine; Potassium; Pyridines; Rana pipiens; Solutions; Structure-Activity Relationship; Surface Tension; Theobromine; Theophylline; Tolazoline; Xanthines

1974
The distribution, activity, and function of the cilia in the frog brain.
    The Journal of physiology, 1974, Volume: 243, Issue:1

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Brain; Caffeine; Cerebrospinal Fluid; Choroid Plexus; Cilia; Cyclic AMP; Depression, Chemical; Dinitrophenols; Ependyma; In Vitro Techniques; Iodoacetates; Ions; Microscopy, Electron, Scanning; Rana catesbeiana; Stimulation, Chemical; Theophylline

1974
Theophylline inhibition of nucleoside transport and its relation to cyclic AMP in skeletal muscle.
    Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:6

    Topics: Adenine; Adenosine; Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Cyclic AMP; Hypoxanthines; In Vitro Techniques; Inosine; Isoproterenol; Muscle Contraction; Muscles; Nucleosides; Phenytoin; Propranolol; Protein Binding; Purines; Rana pipiens; Ribose; Sorbitol; Theophylline; Tritium; Uridine

1974
Hormone-dependent lipolysis in fat-cells from thyroidectomized rats.
    Molecular and cellular endocrinology, 1974, Volume: 1, Issue:5

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cell Membrane; Cyclic AMP; Epinephrine; Fluorides; Glucagon; In Vitro Techniques; Lipid Metabolism; Protein Kinases; Rats; Stimulation, Chemical; Theobromine; Theophylline; Thyroid Gland; Thyroid Hormones; Thyroidectomy

1974
Cyclic AMP-induced tyrosinase synthesis in Neurospora crassa.
    Biochemical and biophysical research communications, 1974, Dec-11, Volume: 61, Issue:3

    Topics: Adenine; Adenosine; Adenosine Monophosphate; Bucladesine; Caffeine; Catechol Oxidase; Cyclic AMP; Cycloheximide; Enzyme Induction; Neurospora; Neurospora crassa; Theophylline

1974
A study of adenosine 3':5'-cyclic monophosphate, sodium butyrate and cortisol as inducers of HeLa alkaline phosphatase.
    Archives of biochemistry and biophysics, 1974, Volume: 164, Issue:2

    Topics: Alkaline Phosphatase; Bucladesine; Butyrates; Caffeine; Carboxylic Acids; Cyclic AMP; Enzyme Induction; Epinephrine; Fluorides; HeLa Cells; Humans; Hydrocortisone; Isoproterenol; Kinetics; Prostaglandins; Theophylline; Time Factors; Xanthines

1974
3':5'-cyclic-AMP phosphodiesterase from Trypanosoma gambiense.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1974, Volume: 355, Issue:11

    Topics: Animals; Caffeine; Cyclic AMP; Dithioerythritol; Enzyme Activation; Hydrogen-Ion Concentration; Imidazoles; Isoelectric Focusing; Kinetics; Magnesium; Manganese; Molecular Weight; Papaverine; Phosphoric Diester Hydrolases; Theophylline; Trypanosoma brucei gambiense

1974
[The treatment of heart and circulatory disorders. 1. Circulatory drugs].
    Tierarztliche Praxis, 1973, Volume: 1, Issue:3

    Topics: Acridines; Angiotensin II; Animals; Blood Pressure; Caffeine; Cardiovascular Diseases; Cardiovascular System; Dog Diseases; Dogs; Epinephrine; Norepinephrine; Octopamine; Peristalsis; Theophylline; Vasopressins

1973
Interaction of four methylxanthine compounds and norepinephrine on cardiac phosphorylase activation and cardiac contractility.
    Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Female; Guinea Pigs; Male; Myocardial Contraction; Myocardium; Nicotine; Norepinephrine; Papaverine; Phosphodiesterase Inhibitors; Phosphorylases; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines

1973
Adenosine-3',5'-monophosphate: intracellular mediator for methyl xanthine stimulation of gastric secretion.
    Gastroenterology, 1969, Volume: 57, Issue:4

    Topics: Animals; Bufo marinus; Caffeine; Cyclic AMP; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Rana pipiens; Theophylline; Time Factors; Xanthines

1969
[Pharmaco-isotope nephrogram and 3-stage clearance in functional renal diagnosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1965, Sep-15, Volume: 20, Issue:18

    Topics: Aminophylline; Caffeine; Ethanolamines; Humans; Kidney Function Tests; Radioisotope Renography; Theophylline

1965
The mechanism of the lipolytic action of catecholamines.
    Annals of the New York Academy of Sciences, 1967, Feb-10, Volume: 139, Issue:3

    Topics: Adenine Nucleotides; Adipose Tissue; Caffeine; Catecholamines; Epinephrine; Ethanolamines; Glycerol; Lipase; Norepinephrine; Phosphotransferases; Theophylline

1967
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.
    The Journal of biological chemistry, 1968, Apr-25, Volume: 243, Issue:8

    Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Cyclic AMP; Drug Synergism; Epinephrine; Ethanolamines; Glucagon; In Vitro Techniques; Insulin; Isoproterenol; Luteinizing Hormone; Male; Nicotinic Acids; Norepinephrine; Rats; Theophylline; Thyrotropin

1968
[Current concepts of the mechanism of stimulation and blockade of adrenergic beta-receptors in the heart].
    Wiener medizinische Wochenschrift (1946), 1969, Jan-11, Volume: 119, Issue:2

    Topics: Adenine Nucleotides; Animals; Caffeine; Catecholamines; Cell Membrane Permeability; Cyclic AMP; Depression, Chemical; Glucosyltransferases; Guinea Pigs; Heart Conduction System; Imidazoles; Isoproterenol; Myocardium; Sensory Receptor Cells; Stimulation, Chemical; Theophylline

1969
[Effect of non-aqueous elution agents on the behavior of extremely weak bases in ion exchange chromatography using an example of pharmaceutical agent mixture].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:10

    Topics: 1-Propanol; Antipyrine; Benzamides; Benzoates; Caffeine; Catechols; Central Nervous System Stimulants; Chromatography, Ion Exchange; Chromatography, Thin Layer; Ethanol; Methanol; Salicylamides; Solvents; Spectrophotometry; Tablets; Theophylline; Ultraviolet Rays; Water

1969
On the regulation of glycogen metabolism in Tetrahymena.
    Archives of biochemistry and biophysics, 1970, Volume: 137, Issue:1

    Topics: Animals; Caffeine; Culture Media; Cyclic AMP; Depression, Chemical; Glucose; Glucosyltransferases; Glycogen; Isoproterenol; Oxygen; Phosphoric Monoester Hydrolases; Reserpine; Stimulation, Chemical; Tetrahymena; Theophylline; Time Factors; Triiodothyronine; Vibration

1970
[Which drugs can cause glaucoma?].
    Therapie der Gegenwart, 1970, Volume: 109, Issue:4

    Topics: Caffeine; Central Nervous System Stimulants; Drug-Related Side Effects and Adverse Reactions; Epinephrine; Ganglionic Blockers; Glaucoma; Humans; Muscle Relaxants, Central; Nitrates; Nitrites; Parasympatholytics; Quaternary Ammonium Compounds; Sulfonamides; Theophylline

1970
Cyclic AMP and adrenergic receptors in melanophore responses to methylxanthines.
    European journal of pharmacology, 1970, Volume: 12, Issue:3

    Topics: Adenine Nucleotides; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Caffeine; Catecholamines; Chromatophores; Cyclic AMP; Female; In Vitro Techniques; Lizards; Male; Melanocyte-Stimulating Hormones; Sensory Receptor Cells; Stimulation, Chemical; Theobromine; Theophylline; Xanthines

1970
Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.
    Journal of neurochemistry, 1971, Volume: 18, Issue:6

    Topics: Adenine Nucleotides; Caffeine; Central Nervous System Stimulants; Cyclic AMP; Electroshock; Ethers; Fluorine; Hyperbaric Oxygenation; Seizures; Telencephalon; Theophylline; Tritium

1971
Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action.
    Circulation research, 1972, Volume: 30, Issue:4

    Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atropine; Caffeine; Calcium; Calcium Isotopes; Cats; Electric Stimulation; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Norepinephrine; Papillary Muscles; Procaine; Propranolol; Reserpine; Strontium; Strontium Isotopes; Theobromine; Theophylline; Time Factors

1972
Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.
    Science (New York, N.Y.), 1972, Apr-28, Volume: 176, Issue:4033

    Topics: Animals; Anxiety; Barbiturates; Brain; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Cyclic AMP; Diazepam; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Punishment; Rats; Theobromine; Theophylline; Tranquilizing Agents

1972
Anxiety or caffeinism: a diagnostic dilemma.
    The American journal of psychiatry, 1974, Volume: 131, Issue:10

    Topics: Adult; Anxiety Disorders; Cacao; Caffeine; Carbonated Beverages; Coffee; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Humans; Male; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders; Tea; Theobromine; Theophylline

1974
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography.
    The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:4

    Topics: Administration, Oral; Aminophylline; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Humans; Hypoxanthines; Methylation; Pressure; Theophylline; Uric Acid; Xanthines

1974
Gas chromatographic analysis of theophylline in human serum.
    Biochemical medicine, 1974, Volume: 11, Issue:1

    Topics: Caffeine; Chromatography, Gas; Ephedrine; Evaluation Studies as Topic; Humans; Hydrocortisone; Mathematics; Methods; Microchemistry; Theophylline; Time Factors

1974
The enhancement of polypeptide synthesis in mammalian systems by methylxanthines.
    FEBS letters, 1974, Sep-01, Volume: 45, Issue:1

    Topics: Aminophylline; Anemia; Animals; Caffeine; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Hydroxyapatites; Peptide Biosynthesis; Peptide Elongation Factors; Phenylalanine; Phenylhydrazines; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes; RNA, Transfer; Theobromine; Theophylline; Time Factors; Ultracentrifugation

1974
[Combinated oral antiasthmatics--how effective are they? An invitation to discussion].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1974, Nov-10, Volume: 94, Issue:31

    Topics: Administration, Oral; Antipyrine; Asthma; Caffeine; Drug Combinations; Ephedrine; Humans; Parasympatholytics; Theophylline

1974
High-pressure liquid chromatographic assay of theophylline in biological fluids.
    Journal of chromatography, 1974, Dec-04, Volume: 101, Issue:1

    Topics: Absorption; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Drug Stability; Humans; Hydrogen-Ion Concentration; Oxazepam; Pressure; Spectrophotometry, Ultraviolet; Temperature; Theophylline; Time Factors; Xanthines

1974
[Biological effectiveness of methyl xanthines in cocoa products].
    Zeitschrift fur Ernahrungswissenschaft, 1974, Volume: 13, Issue:4

    Topics: Animals; Bronchi; Cacao; Caffeine; Cardiovascular System; Central Nervous System; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Female; Humans; Kidney; Mice; Muscles; Receptors, Drug; Theobromine; Theophylline; Xanthines

1974
Relationship between theophylline uptake and inotropic effect in the guinea-pig heart.
    British journal of pharmacology, 1974, Volume: 52, Issue:2

    Topics: Animals; Caffeine; Coronary Vessels; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Myocardium; Perfusion; Stimulation, Chemical; Theophylline

1974
[The effect of methylxanthines on catecholamine and adenylate nucleotide concentration in rat myocardium].
    Biulleten' eksperimental'noi biologii i meditsiny, 1974, Volume: 78, Issue:10

    Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Caffeine; Inosine; Inosine Nucleotides; Myocardium; Phosphorus; Rats; Stimulation, Chemical; Strophanthins; Theobromine; Theophylline; Tyramine; Xanthines

1974
[Determination of substances of biochemical and bromatological interest by complex formation with heterpoly acids. The thermic properties of the complex salts].
    Die Nahrung, 1974, Volume: 18, Issue:8

    Topics: Caffeine; Chemical Phenomena; Chemistry; Cytosine; Hot Temperature; Molybdenum; Phosphates; Phosphotungstic Acid; Silicon; Theobromine; Theophylline; Thiamine; Tungsten; Xanthines

1974
Experimental study of the effect of lithium, haloperidol, caffeine and theophylline on convulsive seizure reactions.
    Acta physiologica et pharmacologica Bulgarica, 1974, Volume: 2

    Topics: Animals; Caffeine; Drug Synergism; Haloperidol; Lithium; Male; Rats; Seizures; Theophylline

1974
Pyrimidine derivatives and related compounds. XXIII. Synthesis and pharmacological properties of 9-deazaxanthine derivatives.
    Chemical & pharmaceutical bulletin, 1974, Volume: 22, Issue:11

    Topics: Animals; Caffeine; Heart; Kidney; Lethal Dose 50; Mice; Motor Activity; Theophylline; Xanthines

1974
[Comparative investigation on the vitro inhibition of adenosine decomposition by dilazep].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:11A Suppl

    Topics: Adenosine; Adult; Azepines; Benzoates; Caffeine; Cell Membrane Permeability; Dipyridamole; Drug Interactions; Erythrocytes; Ethylenediamines; Humans; In Vitro Techniques; Lidoflazine; Theophylline; Vasodilator Agents

1974
Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells.
    Mutation research, 1974, Volume: 26, Issue:2

    Topics: Animals; Caffeine; Carbon Radioisotopes; Cell Line; Cricetinae; DNA; DNA Repair; DNA Replication; L Cells; Leukemia, Lymphoid; Lung; Mice; Mutation; Radiation Effects; Temperature; Theophylline; Thymidine; Ultraviolet Rays

1974
[Differences in the action of etephyl and ethymizol on water and sodium transport through isolated biological membranes].
    Biulleten' eksperimental'noi biologii i meditsiny, 1972, Volume: 73, Issue:7

    Topics: Animals; Anura; Caffeine; Cell Membrane Permeability; Imidazoles; In Vitro Techniques; Male; Pituitary Hormones, Posterior; Rana temporaria; Skin; Theophylline; Urinary Bladder

1972
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:6

    Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Gestational Age; Hypoproteinemia; Methylation; Pregnancy; Rats; Theobromine; Theophylline; Xanthines

1973
Topical differences of caffeine action on the smooth muscle cells of the guinea pig alimentary canal.
    The Japanese journal of physiology, 1974, Volume: 24, Issue:2

    Topics: Adenosine Triphosphate; Animals; Caffeine; Digestive System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium; Rectum; Stomach; Theophylline

1974
Effect of fructose and other sugars on islet function in vitro.
    Acta medica Scandinavica. Supplementum, 1972, Volume: 542

    Topics: Animals; Caffeine; Calcium; Drug Synergism; Fructose; Galactose; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Mannose; Pancreas; Rats; Ribose; Sorbitol; Stimulation, Chemical; Theophylline; Xylitol

1972
Metabolism of caffeine- 3 H in the rat.
    Toxicology and applied pharmacology, 1972, Volume: 23, Issue:4

    Topics: Animals; Caffeine; Chromatography, Thin Layer; Male; Mass Spectrometry; Rats; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Tritium; Uric Acid; Xanthines

1972
Inhibition of alkaline phosphatase by theophylline in vitro.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1972, Volume: 353, Issue:11

    Topics: Alkaline Phosphatase; Animals; Caffeine; Cattle; Humans; In Vitro Techniques; Intestines; Phosphoenolpyruvate; Spectrophotometry; Theobromine; Theophylline

1972
Mass spectrometric identification of methylxanthines and methyluric acids, the possible metabolites of caffeine.
    Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:11

    Topics: Caffeine; Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Theobromine; Theophylline; Uric Acid; Xanthines

1972
[Reaction of purine derivatives with iodine used as a detection reagent. IX].
    Ceskoslovenska farmacie, 1972, Volume: 21, Issue:9

    Topics: Caffeine; Indicators and Reagents; Iodine; Mercaptopurine; Methods; Purines; Spectrophotometry, Infrared; Theobromine; Theophylline

1972
Inhibition of streptolysin O-induced haemolysis by theobromine sodium salicylate.
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Animals; Caffeine; Erythrocytes; Hemolysis; In Vitro Techniques; Rabbits; Salicylates; Streptolysins; Theobromine; Theophylline

1972
On the mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:8

    Topics: Acetamides; Adenosine; Animals; Blood Flow Velocity; Caffeine; Cell Membrane Permeability; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Interactions; Erythrocytes; Female; Glycolates; Humans; Male; Piperazines; Receptors, Drug; Structure-Activity Relationship; Theophylline; Vasodilator Agents; Xanthines; Xylenes

1972
[Determination of the N-methyl group in organic substances on the micro and decimomilligram scale].
    Il Farmaco; edizione scientifica, 1973, Volume: 28, Issue:1

    Topics: Acetanilides; Aminopyrine; Antipyrine; Caffeine; Diphenhydramine; Ephedrine; Indicators and Reagents; Methylation; Microchemistry; Theobromine; Theophylline

1973
A comparative description of inotropic agents in vitro.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 202, Issue:2

    Topics: Animals; Caffeine; Calcium; Cats; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Glucagon; Guinea Pigs; Heart; Heart Atria; Histamine; In Vitro Techniques; Manganese; Muscle Contraction; Muscle, Smooth; Norepinephrine; Ouabain; Papillary Muscles; Propranolol; Rabbits; Reserpine; Serotonin; Temperature; Theophylline; Time Factors

1973
Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. 3. The determination of alkaloids and alkaloidal salts.
    The Analyst, 1973, Volume: 98, Issue:163

    Topics: Alkaloids; Atropine; Caffeine; Codeine; Ephedrine; Indicators and Reagents; Methods; Microchemistry; Nicotine; Papaverine; Polymers; Quinine; Salts; Strychnine; Temperature; Theophylline

1973
[Drug interference and incompatibilities of drugs attacking the central nervous system. 2. Stimulants].
    Fortschritte der Medizin, 1973, May-10, Volume: 91, Issue:13

    Topics: Caffeine; Central Nervous System; Drug Antagonism; Drug Interactions; Drug Synergism; Humans; Methamphetamine; Methylphenidate; Stimulation, Chemical; Sympathomimetics; Theophylline

1973
[Gastrin release by methylxanthine].
    Klinische Wochenschrift, 1973, Volume: 51, Issue:1

    Topics: Adult; Caffeine; Gastric Juice; Gastrins; Humans; Injections, Intravenous; Middle Aged; Stimulation, Chemical; Theophylline

1973
Urinary excretion of 3 -methylxanthine and related compounds in children.
    Clinica chimica acta; international journal of clinical chemistry, 1973, Apr-30, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Cacao; Caffeine; Child; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Paper; Coffee; Diet; Humans; Infant; Intellectual Disability; Mass Spectrometry; Methylation; Neuromuscular Diseases; Spectrophotometry, Ultraviolet; Stereoisomerism; Tea; Theobromine; Theophylline; Xanthines

1973
Application of quantitative thin-layer chromatography in drug assay and stability testing. Determination of codeine phosphate, noscapine, diphenhydramine hydrochloride, phenylephrine hydrochloride, caffeine, etofyllin, phenobarbital and thiamine hydrochlo
    Journal of chromatography, 1973, Jul-18, Volume: 82, Issue:1

    Topics: Autoanalysis; Caffeine; Chromatography, Thin Layer; Codeine; Diphenhydramine; Drug Combinations; Drug Stability; Methods; Noscapine; Pharmaceutical Preparations; Phenobarbital; Phenylephrine; Spectrum Analysis; Theophylline; Thiamine

1973
Stimulation of human spermatozoal motility by caffeine.
    Fertility and sterility, 1973, Volume: 24, Issue:9

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminophylline; Caffeine; Drug Synergism; Fructose; Glucose; Humans; Lactates; Male; Pyruvates; Spermatozoa; Theophylline

1973
The effects of caffeine and theophylline on nociceptive stimulation in the rat.
    Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:1

    Topics: Animals; Caffeine; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intraperitoneal; Male; Motor Activity; Neural Conduction; Pain; Placebos; Rats; Stimulation, Chemical; Theophylline; Time Factors; Vocalization, Animal

1973
Chlorination studies. IV. The reaction of aqueous hypochlorous acid with pyrimidine and purine bases.
    Biochemical and biophysical research communications, 1973, Aug-21, Volume: 53, Issue:4

    Topics: Adenine; Bromouracil; Caffeine; Chemical Phenomena; Chemistry; Guanine; Mass Spectrometry; Purines; Pyrimidines; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Theophylline; Thymine; Uracil; Xanthines

1973
The action of gut glucagon-like immunoreactivity and other intestinal hormones on lipolysis in chicken adipocytes.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:6

    Topics: Adipose Tissue; Animals; Antigen-Antibody Reactions; Caffeine; Chickens; Cholecystokinin; Drug Synergism; Ducks; Duodenum; Gastrins; Gastrointestinal Hormones; Glucagon; Jejunum; Lipid Metabolism; Pancreas; Rats; Secretin; Swine; Theophylline; Tissue Extracts

1973
Factors influencing deceleration of heart and respiratory rates after exercise in the horse.
    Equine veterinary journal, 1973, Volume: 5, Issue:1

    Topics: Amphetamine; Animals; Caffeine; Diethylamines; Electrocardiography; Ephedrine; Female; Heart Rate; Horses; Male; Physical Exertion; Respiration; Sweating; Telemetry; Temperature; Theophylline

1973
The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium.
    The Journal of surgical research, 1974, Volume: 16, Issue:4

    Topics: Action Potentials; Animals; Biological Transport; Caffeine; Calcium; Cell Membrane; Cell Membrane Permeability; Coronary Disease; Cyanides; Depression, Chemical; Dinitrophenols; Electrochemistry; Guinea Pigs; Heart Rate; Hypoxia; Isoproterenol; Membrane Potentials; Myocardial Infarction; Myocardium; Potassium; Sodium; Theophylline; Xanthines

1974
The effect of theophylline on tryptophan pyrrolase in the hypophysectomized rat and some observations on the validity of tryptophan pyrrolase assays.
    The Journal of biological chemistry, 1974, Jun-25, Volume: 249, Issue:12

    Topics: Animals; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Chromatography, Paper; Cycloheximide; Dactinomycin; Enzyme Activation; Hydrocortisone; Hypophysectomy; Kinetics; Liver; Male; Models, Chemical; Perfusion; Pituitary Gland; Rats; Theophylline; Tryptophan; Tryptophan Oxygenase

1974
Determination of theophylline and probenecid in biological material.
    Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:3

    Topics: Animals; Brain Chemistry; Caffeine; Chloroform; Chromatography; Chromatography, Gas; Hydrogen-Ion Concentration; Methods; Probenecid; Solvents; Theobromine; Theophylline; Water

1974
The use of modified cellulose papers in routine toxicological analysis. 3. Xanthine CNS stimulants and antipyretics.
    Die Pharmazie, 1974, Volume: 29, Issue:6

    Topics: Analgesics; Caffeine; Cellulose; Central Nervous System; Chromatography, Paper; Paper; Theobromine; Theophylline; Xanthines

1974
The influence of analogs of xanthine on the mutagenic effect of ultraviolet light.
    Molecular & general genetics : MGG, 1968, Volume: 102, Issue:2

    Topics: Caffeine; Drug Synergism; Escherichia coli; Mutation; Purines; Theophylline; Ultraviolet Rays; Uric Acid; Xanthines

1968
Identification of drugs in the preimplantation blastocyst and in the plasma, uterine secretion and urine of the pregnant rabbit.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:1

    Topics: Animals; Barbiturates; Caffeine; Carbon Isotopes; DDT; Embryo Implantation; Endometrium; Female; Isoniazid; Molecular Weight; Nicotine; Ovum; Pregnancy; Rabbits; Radioisotope Dilution Technique; Theophylline; Thiopental; Tritium; Uterus; Xanthines

1971
Effect of caffeine on adenylosuccinate lyase synthesis in Bacillus subtilis.
    Journal of biochemistry, 1969, Volume: 65, Issue:4

    Topics: Bacillus subtilis; Caffeine; Culture Media; Dactinomycin; Lyases; Nucleosides; Nucleotides; Oxidoreductases; Puromycin; Succinates; Theobromine; Theophylline; Time Factors; Transferases; Xanthines

1969
Inhibition of L-alanine-induced germination of Bacillus cereus spores by theophylline.
    Experientia, 1971, Volume: 27, Issue:8

    Topics: Adenine; Alanine; Bacillus cereus; Caffeine; Drug Synergism; Guanine; Hydrogen-Ion Concentration; Inosine; Spores, Bacterial; Temperature; Theophylline

1971
Effect of theobromine, theophylline and caffeine on the mitosis of human lymphocytes.
    Mutation research, 1972, Volume: 15, Issue:2

    Topics: Caffeine; Cells, Cultured; Colchicine; Female; Humans; Lectins; Lymphocytes; Male; Methods; Mitosis; Sex Factors; Theobromine; Theophylline

1972
[Pharmacological effects on the contraction frequency of isolated rat portal vein].
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 198, Issue:2

    Topics: Aconitum; Animals; Atropine; Caffeine; Carbachol; Epinephrine; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Nitrites; Norepinephrine; Papaverine; Peptides; Phentolamine; Portal Vein; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Reserpine; Strophanthins; Theophylline; Tyramine

1972
Effects of caffeine and theophylline on activity of rats in relation to brain xanthine concentrations.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 139, Issue:2

    Topics: Animals; Blood Proteins; Body Temperature; Brain; Caffeine; Male; Motor Activity; Muscles; Protein Binding; Rats; Stimulation, Chemical; Theophylline; Xanthines

1972
Complexation of acetaminophen with methyl xanthines.
    Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:9

    Topics: Acetaminophen; Caffeine; Calorimetry; Chemistry, Pharmaceutical; Kinetics; Magnetic Resonance Spectroscopy; Solubility; Spectrophotometry; Spectrum Analysis; Theobromine; Theophylline

1972
[Solubilization of khellin due to caffeine and dihydroxypropyltheophylline].
    Die Pharmazie, 1972, Volume: 27, Issue:9

    Topics: Caffeine; Chelating Agents; Chemistry, Pharmaceutical; Drug Stability; Khellin; Solubility; Spectrophotometry; Theophylline; Thermodynamics; Xanthines

1972
[Effect of caffeine and dihydroxyprophyltheophylline on the replacement rate of khellin].
    Die Pharmazie, 1972, Volume: 27, Issue:9

    Topics: Caffeine; Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Khellin; Kinetics; Mathematics; Temperature; Theophylline; Xanthines

1972
[Studies on analysis of mixed anti-cold pharmaceutical preparations. IX. Application of countercurrent distribution method].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1971, Volume: 91, Issue:5

    Topics: Caffeine; Chlorpheniramine; Codeine; Countercurrent Distribution; Ephedrine; Methods; Solubility; Theophylline

1971
Caffeine metabolism by Penicillium roqueforti.
    Archives of biochemistry and biophysics, 1971, Volume: 147, Issue:1

    Topics: Caffeine; Carbon Isotopes; Chromatography, Thin Layer; Dealkylation; Penicillium; Theobromine; Theophylline

1971
Determination of theophylline and caffeine from biological materials.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1971, Volume: 54, Issue:6

    Topics: Animals; Brain Chemistry; Caffeine; Half-Life; Male; Muscles; Protein Binding; Rats; Rats, Inbred Strains; Theophylline

1971
An infrared study of the interaction of caffeine and theophylline with 9-ethyladenine in chloroform solution.
    Molecular pharmacology, 1971, Volume: 7, Issue:2

    Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chloroform; DNA Repair; Drug Interactions; Infrared Rays; Solutions; Spectrum Analysis; Theophylline

1971
Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips.
    British journal of pharmacology, 1971, Volume: 43, Issue:2

    Topics: Animals; Aorta; Caffeine; Catecholamines; Cycloparaffins; Drug Synergism; Epinephrine; In Vitro Techniques; Ketones; Methoxamine; Methylation; Muscle Contraction; Muscle, Smooth; Norepinephrine; Normetanephrine; Phenylephrine; Propiophenones; Pyrogallol; Rabbits; Reserpine; Synephrine; Theophylline; Xanthines

1971
[Electroencephalographic study of the local injection of central nervous stimulants into the brain--xanthinol nicotinate, CDP-choline, caffein and sodium benzoate].
    Shinkei kenkyu no shimpo. Advances in neurological sciences, 1971, Volume: 15, Issue:4

    Topics: Animals; Benzoates; Brain; Caffeine; Cats; Cytosine Nucleotides; Electroencephalography; Hypothalamus; Injections; Mesencephalon; Nicotinic Acids; Pons; Theophylline

1971
The influence of reserpine, propranolol, and adrenal medullectomy on the hyperglycemic actions of theophylline and caffeine.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:1

    Topics: Adrenal Medulla; Aminophylline; Animals; Blood Glucose; Body Temperature; Caffeine; Male; Propranolol; Rats; Reserpine; Stimulation, Chemical; Theophylline; Time Factors

1969
[Solubilization of purines].
    Die Pharmazie, 1969, Volume: 24, Issue:10

    Topics: Caffeine; Polyvinyls; Purines; Solubility; Theobromine; Theophylline

1969
Teratogenic actions of some methylated xanthines in mice.
    Okajimas folia anatomica Japonica, 1969, Volume: 46, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Injections, Intraperitoneal; Male; Mice; Pregnancy; Teratoma; Theobromine; Theophylline

1969
[Simultaneous spectrophotometric determination of the components of a binary mixture with graphic resolution. II].
    Bollettino della Societa italiana di biologia sperimentale, 1969, Jul-31, Volume: 45, Issue:14

    Topics: Amino Alcohols; Caffeine; Spectrophotometry; Theophylline

1969
[Simultaneous spectrophotometric determination of the components of a binary mixture with graphic resolution. I].
    Bollettino della Societa italiana di biologia sperimentale, 1969, Jul-31, Volume: 45, Issue:14

    Topics: Amino Alcohols; Caffeine; Spectrophotometry; Theophylline

1969
Dynamic dialysis as a method for studying protein binding. II. Evaluation of the method with a number of binding systems.
    Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:1

    Topics: Caffeine; Coloring Agents; Dialysis; Hydrogen-Ion Concentration; Kinetics; Methods; Protein Binding; Serum Albumin, Bovine; Spectrophotometry; Theophylline; Warfarin

1970
Molecular interactions of pyrimidines, purines, and some other heteroaromatic compounds in aqueous media.
    Biochemistry, 1970, Feb-03, Volume: 9, Issue:3

    Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chloroquine; Drug Stability; Guanidines; Hypoxanthines; Nucleosides; Purines; Pyrimidines; Quinoxalines; Solubility; Theophylline; Tritium; Water

1970
Complexes of ergot alkaloids and derivatives. 3. Interaction of dihydroergocristine with xanthine analogs in aqueous media.
    Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:3

    Topics: Absorption; Animals; Buffers; Caffeine; Cats; Chemical Phenomena; Chemistry; Drug Synergism; Ergot Alkaloids; Humans; Hydrogen-Ion Concentration; Solubility; Spectrophotometry; Sympathetic Nervous System; Theophylline; Time Factors; Tritium; Water; Xanthines

1970
Detection of theophylline and theobromine by reactions with mercury (II) cyanide.
    Analytica chimica acta, 1970, Volume: 49, Issue:3

    Topics: Caffeine; Chemical Phenomena; Chemistry; Cyanides; Mercury; Theobromine; Theophylline; Xanthines

1970
[Factors influencing behaviour in thin-layer chromatography. 2. Thin-layer chromatography of caffeine, theophylline and theobromine on pH gradient layers].
    Journal of chromatography, 1970, Apr-08, Volume: 48, Issue:1

    Topics: Caffeine; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Theobromine; Theophylline

1970
[Study of the mechanism of the positive inotropic effect exercised by methylxanthines on the isolated perfused rat heart].
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 184, Issue:1

    Topics: Animals; Caffeine; Cardiac Output; Drug Antagonism; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Methods; Norepinephrine; Propranolol; Rats; Reserpine; Theophylline; Xanthines

1970
[Advantage of a new therapeutic agent for respiratory dyspneic diseases].
    Therapeutique (La Semaine des hopitaux), 1970, Volume: 46, Issue:8

    Topics: Asthma; Bronchial Diseases; Bronchodilator Agents; Caffeine; Dyspnea; Male; Parasympatholytics; Theophylline

1970
[Factors influencing behavior in thin-layer chromatography. I. The influence of the pH value in thin-layer chromatography of caffeine theophylline and theobromine on uniform layers].
    Journal of chromatography, 1970, Apr-08, Volume: 48, Issue:1

    Topics: Acids; Ammonia; Caffeine; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Theobromine; Theophylline

1970
[Hepatotoxicity of caffeine and theophylline].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Carbon Tetrachloride Poisoning; Cholesterol; Depression, Chemical; Fats; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Heart Diseases; Lipid Metabolism; Liver; Male; Necrosis; Rats; Stimulation, Chemical; Theophylline; Time Factors

1970
Effect of complex formation on the intestinal absorption of tryptophan.
    Chemical & pharmaceutical bulletin, 1970, Volume: 18, Issue:11

    Topics: Animals; Caffeine; Flavin Mononucleotide; Intestinal Absorption; Kinetics; Male; Methionine; Perfusion; Rats; Spectrophotometry; Theophylline; Tryptophan

1970
Binding specificity between small organic solutes in aqueous solution: classification of some solutes into two groups according to binding tendencies.
    Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:11

    Topics: Caffeine; Cinnamates; Drug Stability; Mathematics; Phenacetin; Solubility; Theophylline

1970
[Interaction between xanthines and noradrenaline- 3 H in the isolated rat heart].
    Biochemical pharmacology, 1970, Volume: 19, Issue:6

    Topics: Animals; Caffeine; Cardiac Output; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Myocardium; Norepinephrine; Perfusion; Rats; Theobromine; Theophylline; Tritium

1970
[Effect of caffeine on the autoregulation of perfusion flow in the isolated, artificially perfused rat kidney].
    Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1971, Volume: 154, Issue:2

    Topics: Animals; Caffeine; Depression, Chemical; In Vitro Techniques; Kidney; Perfusion; Rats; Reserpine; Rheology; Theophylline; Tyramine

1971
[On the occurrence of theophylline in coffee].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1967, Volume: 348, Issue:12

    Topics: Caffeine; Chromatography, Thin Layer; Coffee; Theobromine; Theophylline

1967
[Contribution to the treatment of depressions].
    Die Medizinische Welt, 1967, Jun-03, Volume: 22

    Topics: Aged; Antidepressive Agents; Caffeine; Depression; Depressive Disorder, Major; Female; Humans; Injections, Intravenous; Male; Middle Aged; Suicide Prevention; Testosterone; Theophylline; Vasodilator Agents; World Health Organization

1967
[Electronic properties of N-heteroaromatics. XI. Interaction of p-benzoquinone with caffeine and theophylline].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1967, Volume: 87, Issue:10

    Topics: Caffeine; Electrochemistry; Quinones; Solubility; Spectrum Analysis; Theophylline

1967
[Studies on caffeine from synthesis and biosynthesis].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:1

    Topics: Caffeine; Chromatography; Chromatography, Thin Layer; Methods; Pharmacopoeias as Topic; Plants, Medicinal; Theobromine; Theophylline

1967
Permeation of purine derivatives into the cerebrospinal fluid of dogs.
    Experientia, 1968, Jan-15, Volume: 24, Issue:1

    Topics: Amphetamine; Animals; Benzoates; Blood-Brain Barrier; Caffeine; Dogs; Ethylenediamines; Theobromine; Theophylline

1968
The effect of caffeine on drug metabolism.
    Life sciences, 1968, Feb-01, Volume: 7, Issue:3

    Topics: Acetanilides; Aminopyrine; Animals; Caffeine; Enzyme Induction; Ethionine; Liver; Microsomes; Nitrobenzenes; Puromycin; Rats; Theobromine; Theophylline

1968
Interactions of xanthine derivatives with bovine serum albumin. 3. Inhibition of binding.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:2

    Topics: Acetates; Aspirin; Benzoates; Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Chlorides; Hydrogen-Ion Concentration; Nitrates; Potassium; Protein Binding; Salicylates; Serum Albumin, Bovine; Sodium; Sulfates; Theophylline; Xanthines

1968
Structural studies on complexes. I. Postulation of polarization bonding in xanthine complexes.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:2

    Topics: Caffeine; Chemical Phenomena; Chemistry; Electrochemistry; Models, Chemical; Theophylline; Uric Acid; Xanthines

1968
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental

1968
[Determination of theophylline, caffeine and ephedrine hydrochloride in the preparation Belladrinal tablet].
    Acta poloniae pharmaceutica, 1968, Volume: 25, Issue:1

    Topics: Caffeine; Chlorides; Chromatography, Paper; Colorimetry; Ephedrine; Methods; Potentiometry; Tablets; Theophylline

1968
Interaction of copper ion with guanosine and related compounds.
    Biochemistry, 1968, Volume: 7, Issue:12

    Topics: Caffeine; Chemical Phenomena; Chemistry; Copper; Cytosine Nucleotides; Electric Conductivity; Guanine Nucleotides; Models, Structural; Nucleosides; Nucleotides; Potentiometry; Ribose; Spectrophotometry; Theophylline; Uracil Nucleotides; Uridine

1968
Determination of molecular binding in aqueous solution from optical activity measurements. Interaction of tryptophan with alkylxanthines.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:11

    Topics: Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Mathematics; Methods; Optical Rotatory Dispersion; Spectrum Analysis; Theophylline; Tryptophan; Xanthines

1968
[Diuretic effect of purine derivatives based on the perfusion of the isolated kidney of dogs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1968, Nov-20, Volume: 64, Issue:6

    Topics: Animals; Caffeine; Diuretics; Dogs; Glomerular Filtration Rate; Kidney; Oxygen Consumption; Perfusion; Potassium; Sodium; Theobromine; Theophylline; Time Factors; Vascular Resistance

1968
Effect of adenine nucleotides on thyroid hormone release in vivo and in vitro.
    Metabolism: clinical and experimental, 1969, Volume: 18, Issue:4

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Caffeine; Drug Synergism; Fluorides; In Vitro Techniques; Iodine Isotopes; Mice; Nucleosides; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine

1969
Interactions between pharmaceutical compounds by thermal methods.
    Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:3

    Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K

1969
[On the mechanism of the calorigenic effect of theophylline and caffeine].
    Biochemical pharmacology, 1969, Volume: 18, Issue:5

    Topics: Adrenal Medulla; Adrenalectomy; Anesthesia; Animals; Caffeine; Calorimetry; Epinephrine; Oxygen Consumption; Propranolol; Rats; Reserpine; Theophylline; Wakefulness

1969
Determination of caffeine in serum and urine.
    Clinical chemistry, 1969, Volume: 15, Issue:8

    Topics: Benzene; Caffeine; Indicators and Reagents; Methods; Spectrum Analysis; Theobromine; Theophylline

1969
Interactions of xanthine derivatives with bovine serum albumin. II. Spectrophotometric studies.
    Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:5

    Topics: Caffeine; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Serum Albumin, Bovine; Spectrophotometry; Temperature; Theophylline; Xanthines

1965
Solubility profiles for the xanthines in dioxane--water mixtures.
    Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:6

    Topics: Caffeine; Dioxins; Solubility; Spectrophotometry; Theobromine; Theophylline

1965
[A new method for thin-layer chromatographic separation of caffeine, theobromin and theophylline].
    Acta pharmaceutica Hungarica, 1965, Volume: 35, Issue:5

    Topics: Caffeine; Chromatography, Thin Layer; In Vitro Techniques; Theobromine; Theophylline

1965
Quantum chemical considerations on the stability of aqueous solution of an electron acceptor such as menadione.
    Chemical & pharmaceutical bulletin, 1965, Volume: 13, Issue:1

    Topics: Antipyrine; Caffeine; Chemical Phenomena; Chemistry, Physical; Theophylline; Vitamin K

1965
[Study of solvent effect on nuclear magnetic resonance. I. Caffeine and its derivatives].
    Tetrahedron, 1965, Volume: 21, Issue:12

    Topics: Caffeine; Hydrocarbons, Halogenated; Magnetic Resonance Spectroscopy; Solvents; Theobromine; Theophylline

1965
Analysis of selected pharmaceuticals by quantitative thin-layer chromatography.
    Journal of pharmaceutical sciences, 1966, Volume: 55, Issue:9

    Topics: Amphetamine; Aspirin; Barbiturates; Caffeine; Chromatography, Thin Layer; Ephedrine; Methamphetamine; Phenacetin; Salicylates; Theophylline

1966
[Thin-layer chromatographic separation of some purine derivatives, including uric acid].
    Journal of chromatography, 1966, Volume: 21, Issue:1

    Topics: Adenine; Caffeine; Chromatography, Thin Layer; Guanine; Hypoxanthines; Purines; Theobromine; Theophylline; Uric Acid; Xanthines

1966
[Caffeine and theophyllin mutagenesis in cell and leukocyte cultures of man].
    Mutation research, 1966, Volume: 3, Issue:3

    Topics: Caffeine; Chromosomes; Culture Techniques; Leukocytes; Mutagens; Theophylline

1966
[Detection of caffeine, theophylline, theobromine and some of their derivatives by thin layer chromatography].
    Archiv fur Toxikologie, 1966, Volume: 21, Issue:6

    Topics: Blood Chemical Analysis; Caffeine; Chromatography, Thin Layer; Humans; Indicators and Reagents; Male; Solvents; Theobromine; Theophylline; Urine

1966
[Gas chromatographic separation of various xanthine derivatives].
    Die Pharmazie, 1966, Volume: 21, Issue:8

    Topics: Caffeine; Chromatography, Gas; Theobromine; Theophylline; Xanthines

1966
[Determination of Theobromine and its metabolites in urine].
    Deutsche Zeitschrift fur die gesamte gerichtliche Medizin, 1966, Volume: 57, Issue:3

    Topics: Caffeine; Chromatography, Paper; Food Contamination; Humans; Spectrophotometry; Theobromine; Theophylline; Xanthines

1966
[The treatment of bronchial asthma and the combination treatment of acute and chronic bronchial, bronchopulmonary and pulmonary infections with Asthma 23D. An experience report of medical practice during the time period of 5 years].
    Wiener medizinische Wochenschrift (1946), 1966, Jul-09, Volume: 116, Issue:28

    Topics: Acute Disease; Adult; Aminopyrine; Anti-Bacterial Agents; Antitubercular Agents; Asthma; Atropa belladonna; Bronchitis; Caffeine; Child; Child, Preschool; Chronic Disease; Ephedrine; Humans; Infant; Naphthaleneacetic Acids; Papaverine; Phytotherapy; Plants, Medicinal; Plants, Toxic; Pulmonary Emphysema; Theophylline; Tuberculosis, Pulmonary

1966
Potential anticancer agents V. Synthesis of folic acid and pteroic acid analogs derived of caffeine and theophylline.
    Arzneimittel-Forschung, 1966, Volume: 16, Issue:4

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Caffeine; Folic Acid; Leukemia, Experimental; Mice; Theophylline

1966
The action of imidazole on the effects of methyl-xanthines and catecholamines on cardiac contraction and phosphorylase activity.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 156, Issue:3

    Topics: Adenine Nucleotides; Aminophylline; Animals; Caffeine; Drug Antagonism; Glucosyltransferases; Guinea Pigs; Heart; Imidazoles; Isoproterenol; Myocardium; Norepinephrine; Perfusion; Rabbits; Theophylline

1967
Modification of reaction rates by complex formation. II. Inhibition of the rate of alkaline hydrolysis of methyl trans-cinnamate by some heterocyclic compounds.
    Journal of the American Chemical Society, 1967, Jan-18, Volume: 89, Issue:2

    Topics: Acetates; Benzimidazoles; Caffeine; Chemical Phenomena; Chemistry; Cinnamates; Guanine; Imidazoles; Purines; Theophylline; Uracil

1967
Effect of functional group substituents on the paper chromatography of purines and pyrimidines.
    Analytical biochemistry, 1967, Volume: 19, Issue:3

    Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Paper; Cytosine; Guanine; Hydrogen-Ion Concentration; Nitriles; Purines; Pyrimidines; Theobromine; Theophylline; Thymine; Uracil; Water; Xanthines

1967
Electrical conductivity of a docusate sodium coacervate system.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:12

    Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Cytoplasm; Dioctyl Sulfosuccinic Acid; Electric Conductivity; Glucose; Glucosephosphates; Humans; Models, Biological; Succinates; Sucrose; Theobromine; Theophylline

1984
Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system.
    Epilepsia, 1984, Volume: 25, Issue:4

    Topics: Adenosine; Animals; Anticonvulsants; Brain; Caffeine; Carbamazepine; Cerebellum; Cerebral Cortex; Cyclic AMP; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline

1984
Adrenergic-cholinergic interactions on membrane potential of K+ -depolarized ventricular muscle.
    The American journal of physiology, 1984, Volume: 247, Issue:2 Pt 2

    Topics: Acetylcholine; Action Potentials; Animals; Barium; Caffeine; Electric Conductivity; Guinea Pigs; Histamine; Ion Channels; Isoproterenol; Manganese; Myocardial Contraction; Potassium; Receptors, Adrenergic, beta; Receptors, Muscarinic; Theophylline

1984
Adenosine analogs: potentiation of bradykinin-induced plasma exudation in rat skin and prevention by caffeine and theophylline.
    Life sciences, 1984, Oct-08, Volume: 35, Issue:15

    Topics: Adenosine; Animals; Bradykinin; Caffeine; Capillary Permeability; Cyproheptadine; Drug Synergism; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Skin; Theophylline

1984
Central nervous system pharmacology of the dietary methylxanthines.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Acetylcholine; Adolescent; Adult; Aged; Body Weight; Caffeine; Central Nervous System; Diet; Dopamine; Dose-Response Relationship, Drug; Feeding Behavior; Female; Humans; Lethal Dose 50; Male; Middle Aged; Motor Activity; Norepinephrine; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; Serotonin; Sleep; Substance-Related Disorders; Theobromine; Theophylline

1984
The effects of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperatures.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:3

    Topics: Animals; Body Temperature Regulation; Caffeine; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Phentolamine; Propranolol; Rats; Temperature; Theophylline

1980
The effects of melanophore-stimulating hormone and cyclic nucleotides on teleost fish chromatophores.
    General and comparative endocrinology, 1980, Volume: 42, Issue:4

    Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Bucladesine; Caffeine; Chromatophores; Cyclic AMP; Dibutyryl Cyclic GMP; Epinephrine; Fishes; Melanocyte-Stimulating Hormones; Melanophores; Nucleotides, Cyclic; Pigmentation; Theophylline

1980
Effects of methylxanthines on lipid synthesis in developing neural systems.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol; Fatty Acid Synthases; Fatty Acids; Female; Glioma; Humans; Lipids; Pregnancy; Theophylline

1981
Adenosine mediates sedative action of various centrally active drugs.
    Medical hypotheses, 1982, Volume: 9, Issue:4

    Topics: Adenosine; Animals; Antipsychotic Agents; Arousal; Brain; Caffeine; Diazepam; Hypnotics and Sedatives; Phenothiazines; Rats; Receptors, Cell Surface; Receptors, Purinergic; Synapses; Synaptic Transmission; Synaptosomes; Theophylline

1982
Effects of c-AMP, caffeine, theophylline, and vinblastine on spontaneous transmitter release at locust nerve-muscle junctions.
    Journal of neurobiology, 1983, Volume: 14, Issue:5

    Topics: Animals; Caffeine; Cyclic AMP; Grasshoppers; In Vitro Techniques; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Synaptic Transmission; Theophylline; Vinblastine

1983
External malformations in chick embryos following concomitant administration of methylxanthines and beta-adrenomimetic agents: 1. Gross pathologic features.
    Teratology, 1983, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Adrenergic beta-Agonists; Animals; Caffeine; Chick Embryo; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fetal Viability; Isoproterenol; Mitosis; Norepinephrine; Phenylephrine; Theophylline

1983
Behavioural problems in children taking theophylline.
    Lancet (London, England), 1984, Apr-28, Volume: 1, Issue:8383

    Topics: Adult; Asthma; Caffeine; Child; Child Behavior Disorders; Depressive Disorder; Female; Humans; Theophylline

1984
Interactions between catecholamines, methyl xanthines and adenosine in regulation of cyclic AMP accumulation in hamster adipocytes.
    Biochimica et biophysica acta, 1980, Apr-17, Volume: 629, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Caffeine; Catecholamines; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Mesocricetus; Norepinephrine; Phentolamine; Theophylline

1980
Methylxanthines modulate adenosine release from slices of cerebral cortex.
    Brain research, 1981, Mar-02, Volume: 207, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine Triphosphatases; Aminophylline; Animals; Caffeine; Cerebral Cortex; Cyclic AMP; gamma-Aminobutyric Acid; Male; Mice; Ouabain; Theophylline; Xanthines

1981
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
    Federation proceedings, 1981, Volume: 40, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines

1981
Methylxanthine effects on cyclic adenosine 3':5' monophosphate phosphodiesterase activity in preparations of neonatal rat cerebellum: modification by trifluoperazine.
    Biochemical and biophysical research communications, 1981, Feb-12, Volume: 98, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Animals, Newborn; Caffeine; Cerebellum; Drug Interactions; In Vitro Techniques; Kinetics; Rats; Theophylline; Trifluoperazine

1981
Adenosine 3',5'-phosphate phosphodiesterase and pheromone response in the yeast Saccharomyces cerevisiae.
    Journal of bacteriology, 1981, Volume: 148, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Caffeine; Cyclic AMP; Interphase; Mating Factor; Peptides; Saccharomyces cerevisiae; Theophylline; Xanthines

1981
cAMP and calcium in generation of slow waves in cat colon.
    The American journal of physiology, 1982, Volume: 242, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Caffeine; Calcium; Cats; Colon; Cyclic AMP; Dibutyryl Cyclic GMP; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Theophylline; Time Factors

1982
The action of phosphodiesterase inhibitors on the hypersensitivity of frog photoreceptor.
    Vision research, 1982, Volume: 22, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; In Vitro Techniques; Light; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Rana catesbeiana; Theophylline

1982
Blockade by haloperidol of the increase in tryptophan hydroxylase activity induced by incubation of slices of brain stem with dibutyryl cyclic AMP.
    Biochemical pharmacology, 1982, Jun-15, Volume: 31, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Stem; Bucladesine; Caffeine; Calcium; Haloperidol; Male; Rats; Theophylline; Tryptophan Hydroxylase

1982
Theophylline, dyphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay.
    Clinical chemistry, 1982, Volume: 28, Issue:10

    Topics: Acecainide; Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Pharmaceutical Preparations; Procainamide; Salicylates; Salicylic Acid; Theophylline

1982
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A.
    Canadian journal of microbiology, 1982, Volume: 28, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline

1982
Development and initiation of sperm motility in the hamster epididymis.
    Reproduction, nutrition, developpement, 1980, Volume: 20, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cricetinae; Cyclic AMP; Epididymis; Kinetics; Male; Semen; Sperm Motility; Spermatozoa; Theophylline

1980
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum.
    Radiation research, 1984, Volume: 97, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors

1984
Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa.
    The Journal of biological chemistry, 1984, May-10, Volume: 259, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Biological Transport, Active; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Male; Mollusca; Potassium Cyanide; Spermatozoa; Theobromine; Theophylline; Xanthines

1984
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine.
    Biochemical pharmacology, 1984, Jun-01, Volume: 33, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines

1984
Behavioral interaction of adenosine and methylxanthines on central purinergic systems.
    Neuroscience letters, 1984, Jun-15, Volume: 47, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline

1984
Caffeine and related methylxanthines: possible naturally occurring pesticides.
    Science (New York, N.Y.), 1984, Oct-12, Volume: 226, Issue:4671

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Chlorphenamidine; Cyclic AMP; Feeding Behavior; Insecta; Insecticides; Larva; Lepidoptera; Moths; Papaverine; Pesticide Synergists; Theophylline; Xanthines

1984
The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Caffeine; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline; Xanthines

1984
Mode of inhibition of DNA replication in neocarzinostatin-treated HeLa cells.
    Biochimica et biophysica acta, 1983, Aug-02, Volume: 740, Issue:3

    Topics: Antibiotics, Antineoplastic; Caffeine; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Kinetics; Molecular Weight; Theophylline; Zinostatin

1983
cAMP phosphodiesterase and activator protein of mammalian cAMP phosphodiesterase from Trypanosoma cruzi.
    Molecular and biochemical parasitology, 1980, Volume: 1, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Calcium; Calcium-Binding Proteins; Calmodulin; Cyclic AMP; Enzyme Activation; Hydrogen-Ion Concentration; Manganese; Theophylline; Trypanosoma cruzi

1980
Effect of cyclic AMP phosphodiesterase inhibitors on cardiac sarcolemmal 5'-nucleotidase.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 5'-Nucleotidase; Animals; Caffeine; Dipyridamole; In Vitro Techniques; Male; Myocardium; Nucleotidases; Papaverine; Rats; Sarcolemma; Theophylline

1981
Inhibition of 2',3'-cyclic nucleotide 3'-phosphodiesterase activity from bovine, human and guinea pig brain.
    Brain research, 1981, Jun-15, Volume: 214, Issue:2

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain; Caffeine; Cattle; Guinea Pigs; Humans; Kinetics; Oligodendroglia; Organomercury Compounds; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Theophylline

1981
Effect of cAMP, Mn2+, and phosphodiesterase inhibitors on human sperm motility.
    Archives of andrology, 1981, Volume: 7, Issue:4

    Topics: Caffeine; Cyclic AMP; Humans; Male; Manganese; Phosphodiesterase Inhibitors; Sperm Motility; Theophylline; Time Factors

1981
Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1982, Volume: 41, Issue:1

    Topics: Animals; Bucladesine; Caffeine; Cell Division; Cells, Cultured; Cricetinae; Cricetulus; Female; Ovary; Theobromine; Theophylline; X-Rays

1982
Possible role of the transverse tubules in accumulating calcium released from the terminal cisternae by stimulation and drugs.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:4

    Topics: Animals; Anura; Caffeine; Calcium; Electric Stimulation; In Vitro Techniques; Ion Channels; Muscle Contraction; Muscles; Strontium; Theophylline

1982
Intracellular Ca2+ transients in the cat papillary muscle.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:4

    Topics: Action Potentials; Aequorin; Animals; Caffeine; Calcium; Cats; Cyclic AMP; Dogs; Heart; In Vitro Techniques; Ion Channels; Myocardial Contraction; Papillary Muscles; Sarcoplasmic Reticulum; Theophylline; Troponin; Troponin C

1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1982, Volume: 52, Issue:6

    Topics: Animals; Bucladesine; Caffeine; Choline; Dexamethasone; Drug Synergism; Hormones; Lung; Organ Culture Techniques; Phosphatidylcholines; Rats; Theophylline; Triiodothyronine

1982
Endogenous peptides that inhibit brain cyclic AMP phosphodiesterase.
    Journal of neurochemistry, 1982, Volume: 38, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Brain Chemistry; Caffeine; Cattle; Chromatography, Gel; Male; Molecular Weight; Peptides; Rats; Theophylline

1982
Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain.
    Neuroscience letters, 1982, May-28, Volume: 30, Issue:2

    Topics: Adenosine; Binding, Competitive; Brain; Caffeine; Diazepam; Humans; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Purinergic; Theophylline; Xanthines

1982
Inhibition of a high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Dogs; Etazolate; Female; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Theophylline; Trachea; Xanthines

1982
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines.
    Cellular and molecular neurobiology, 1983, Volume: 3, Issue:1

    Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Animals; Brain; Caffeine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theobromine; Theophylline; Xanthines

1983
Evidence for the presence of P1- and P2-purinoceptors in rat caecum.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 264, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Caffeine; Cecum; Cyclic AMP; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Quinidine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline

1983
Influence of carbohydrates on growth and sporulation of Clostridium perfringens in a defined medium with or without guanosine.
    Applied and environmental microbiology, 1983, Volume: 46, Issue:5

    Topics: Caffeine; Carbohydrates; Clostridium perfringens; Culture Media; Dextrins; Glucose; Guanosine; Melibiose; Raffinose; Spores, Bacterial; Sucrose; Theophylline

1983
Caffeine inhibition of aflatoxin production: mode of action.
    Applied and environmental microbiology, 1983, Volume: 46, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Aflatoxins; Aspergillus; Caffeine; Cell Nucleus; Cytoplasm; Guanine; Structure-Activity Relationship; Theophylline; Trace Elements

1983
Interaction between methylxanthines and the benzodiazepine receptor.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 265, Issue:1

    Topics: Animals; Brain; Caffeine; Flunitrazepam; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Theophylline

1983
In vitro and in vivo displacement of [3H]-diazepam binding by purine derivatives in developing rat brain.
    Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:3

    Topics: Animals; Binding, Competitive; Brain; Caffeine; Diazepam; Female; In Vitro Techniques; Kinetics; Male; Membranes; Pregnancy; Purines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Theophylline

1984
Opposing actions of methylxanthines and dibutyryl cyclic AMP on 1,25 dihydroxyvitamin D3 production and calcium fluxes in isolated chick renal tubules.
    Biochemical and biophysical research communications, 1984, May-31, Volume: 121, Issue:1

    Topics: Animals; Bucladesine; Caffeine; Calcitriol; Calcium; Chickens; Cyclic AMP; In Vitro Techniques; Kidney Tubules; Male; Mitochondria; Theophylline

1984
Concurrent measurement of theophylline and caffeine in neonates by an interference-free liquid-chromatographic method.
    Clinical chemistry, 1983, Volume: 29, Issue:11

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Theophylline

1983
Effect of colchicine & methylated purines on UV-induced mitotic gene conversion in Saccharomyces cerevisiae.
    Indian journal of experimental biology, 1983, Volume: 21, Issue:7

    Topics: Caffeine; Colchicine; Gene Conversion; Genes, Fungal; Mitosis; Saccharomyces cerevisiae; Theobromine; Theophylline; Ultraviolet Rays

1983
Evaluation of caffeine plasma levels by an automated enzyme immunoassay (EMIT) in comparison with a high-performance liquid chromatographic method.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:3

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Liver Diseases; Reagent Kits, Diagnostic; Theophylline

1984
Stereospecific stimulation of coronary vascular PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
    Biomedica biochimica acta, 1984, Volume: 43, Issue:8-9

    Topics: Animals; Caffeine; Cattle; Coronary Vessels; Epoprostenol; In Vitro Techniques; Muscle Relaxation; Nitrates; Sugar Alcohols; Theophylline

1984
Induction at high frequency of a unique phenotypic class of Bacillus subtilis mutants by methylxanthines.
    Mutation research, 1983, Volume: 117, Issue:1-2

    Topics: Acriflavine; Aminoacridines; Bacillus subtilis; Caffeine; Mutagenicity Tests; Mutagens; Mutation; Phenotype; Structure-Activity Relationship; Theophylline

1983
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
    Teratology, 1983, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Mitomycin; Mitomycins; Pregnancy; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines

1983
[Effect of CNS stimulators on conditioned reflex activity in rats].
    Eksperimentalna meditsina i morfologiia, 1984, Volume: 23, Issue:2

    Topics: Amphetamine; Amphetamines; Animals; Caffeine; Central Nervous System Agents; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Quinolines; Quinolones; Rats; Reinforcement, Psychology; Stimulation, Chemical; Theophylline

1984
The effects of caffeine and theophylline on diaphragm contractility.
    The American review of respiratory disease, 1984, Volume: 130, Issue:3

    Topics: Adult; Caffeine; Catheterization; Diaphragm; Electromyography; Esophagus; Humans; Male; Muscle Contraction; Pressure; Stomach; Theophylline

1984
Caffeine measured in serum from infants with the theophylline channel of the Abbott TDx.
    Clinical chemistry, 1984, Volume: 30, Issue:10

    Topics: Autoanalysis; Caffeine; Humans; Infant, Newborn; Theophylline

1984
Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Conditioning, Psychological; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Theophylline; Xanthines

1984
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
    Brain & development, 1984, Volume: 6, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines

1984
Differences in steady-state plasma levels between aminophylline and theophylline sustained-release micropellets after repeated circadian dosing.
    International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:11

    Topics: Absorption; Administration, Oral; Adult; Aminophylline; Biological Availability; Caffeine; Chromatography, High Pressure Liquid; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Humans; Kinetics; Male; Random Allocation; Theophylline

1984
Ontogeny of human caffeine and theophylline metabolism.
    Developmental pharmacology and therapeutics, 1984, Volume: 7 Suppl 1

    Topics: Adult; Aged; Apnea; Caffeine; Child; Child, Preschool; Half-Life; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Middle Aged; Theophylline

1984
[Effect of theophylline and theobromine on cell respiration and calcium transport in isolated rat liver mitochondria].
    Revista espanola de fisiologia, 1984, Volume: 40, Issue:3

    Topics: Animals; Biological Transport, Active; Caffeine; Calcium; Female; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1984
Caffeine and its metabolites in caffeine overdose cause falsely elevated serum theophylline measurements.
    Veterinary and human toxicology, 1984, Volume: 26 Suppl 2

    Topics: Caffeine; Chromatography, High Pressure Liquid; False Positive Reactions; Female; Humans; Infant; Theophylline

1984
Caffeine, theophylline and theobromine in pregnancy.
    Biological research in pregnancy and perinatology, 1984, Volume: 5, Issue:4

    Topics: Caffeine; Female; Humans; Pregnancy; Theobromine; Theophylline

1984
Unsuspected caffeine toxicity complicating theophylline therapy.
    Human toxicology, 1984, Volume: 3, Issue:6

    Topics: Bronchitis; Caffeine; Half-Life; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Theophylline

1984
Tea: the plant and its manufacture; chemistry and consumption of the beverage.
    Progress in clinical and biological research, 1984, Volume: 158

    Topics: Beverages; Caffeine; Drinking; Flavanones; Flavins; Flavonoids; Food Handling; Humans; Tea; Theobromine; Theophylline

1984
Improved micro-method for the high-performance liquid chromatographic determination of caffeine and paraxanthine in biological fluids.
    Journal of chromatography, 1984, Dec-12, Volume: 336, Issue:2

    Topics: Animals; Body Fluids; Caffeine; Chromatography, High Pressure Liquid; Female; Fetal Blood; Pregnancy; Rabbits; Solvents; Spectrophotometry, Ultraviolet; Theophylline

1984
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.
    British journal of pharmacology, 1983, Volume: 80, Issue:4

    Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rats; Theophylline; Xanthines

1983
Adenosine strongly potentiates pressor responses to nicotine in rats.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:17

    Topics: Adenosine; Animals; Blood Pressure; Caffeine; Drug Synergism; Electric Stimulation; Male; Nicotine; Phenylephrine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline

1984
The pharmacological characterization of aqueous extracts of vegetable dusts.
    Lung, 1983, Volume: 161, Issue:5

    Topics: Animals; Caffeine; Coffee; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Plant Extracts; Tea; Theophylline; Trachea

1983
Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat.
    Pflugers Archiv : European journal of physiology, 1983, Volume: 398, Issue:3

    Topics: Animals; Biomechanical Phenomena; Caffeine; Calcium; Female; In Vitro Techniques; Male; Muscles; Papillary Muscles; Rats; Sarcoplasmic Reticulum; Theophylline

1983
Some infants receiving theophylline may have caffeine in serum.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:3

    Topics: Aminophylline; Bronchitis; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Male; Theophylline

1983
Caffeine-enhanced survival of radiation-sensitive, repair-deficient Chinese hamster cells.
    Radiation research, 1983, Volume: 96, Issue:2

    Topics: Animals; Caffeine; Cell Line; Cell Survival; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; DNA Repair; Neutrons; Radiation Tolerance; Theophylline

1983
Influence of some common methylxanthines on contractile responses and calcium mobilization of ileal, vas deferens and bladder smooth muscle.
    The Journal of experimental biology, 1983, Volume: 107

    Topics: Animals; Caffeine; Calcium; Ileum; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Urinary Bladder; Vas Deferens; Xanthines

1983
T4 levels in methylxanthine-treated premature newborns.
    Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:3-4

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Retrospective Studies; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine

1983
Novel form of drug-dependence--on adenosine in guinea pig ileum.
    Nature, 1983, Apr-14, Volume: 302, Issue:5909

    Topics: Adenosine; Animals; Caffeine; Guinea Pigs; Humans; Ileum; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Substance-Related Disorders; Theophylline

1983
The bronchodilator effects and pharmacokinetics of caffeine in asthma.
    The New England journal of medicine, 1984, Mar-22, Volume: 310, Issue:12

    Topics: Adolescent; Asthma; Bronchodilator Agents; Caffeine; Child; Double-Blind Method; Humans; Kinetics; Random Allocation; Respiratory Function Tests; Theophylline

1984
Effects of dantrolene and methylxanthines on the sensory nerve terminal of the frog muscle spindle.
    Brain research, 1984, Mar-05, Volume: 294, Issue:2

    Topics: Animals; Axons; Caffeine; Dantrolene; Evoked Potentials; Microscopy, Electron; Neuromuscular Junction; Pentylenetetrazole; Ranidae; Theophylline; Time Factors

1984
Determination of caffeine, theophylline and theobromine in serum and saliva using high-performance liquid chromatography.
    Annals of clinical biochemistry, 1984, Volume: 21 ( Pt 2)

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Saliva; Theobromine; Theophylline

1984
Simultaneous determination of caffeine and its N-demethylated metabolites in umbilical cord plasma using high-performance liquid chromatography.
    Journal of chromatography, 1984, Mar-09, Volume: 306

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Dealkylation; Female; Fetal Blood; Humans; Infant; Theobromine; Theophylline

1984
High-performance liquid chromatographic determination of theobromine, theophylline and caffeine in food products.
    Journal of chromatography, 1984, May-18, Volume: 291

    Topics: Beverages; Cacao; Caffeine; Candy; Chromatography, High Pressure Liquid; Coffee; Hydrogen-Ion Concentration; Theobromine; Theophylline

1984
The effect of caffeine, theophylline and amphetamine on operant responding of the mouse.
    Psychopharmacology, 1980, Volume: 68, Issue:2

    Topics: Amphetamine; Animals; Caffeine; Conditioning, Operant; Male; Mice; Mice, Inbred C57BL; Reinforcement Schedule; Theophylline

1980
Automated on-line multi-dimensional high-performance liquid chromatographic techniques for the clean-up and analysis of water-soluble samples.
    Journal of chromatography, 1981, Feb-06, Volume: 206, Issue:1

    Topics: Body Fluids; Caffeine; Carbohydrates; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Food Analysis; Humans; Solubility; Theophylline; Vitamins; Water

1981
Caffeine discrimination in the rat.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:5

    Topics: Animals; Caffeine; Conditioning, Operant; Dextroamphetamine; Generalization, Stimulus; Male; Methylphenidate; Motor Activity; Nicotine; Prejudice; Rats; Theophylline; Thyrotropin-Releasing Hormone

1981
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
    Life sciences, 1982, Sep-06, Volume: 31, Issue:10

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline

1982
Optic cup formation: a calcium-regulated process.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:18

    Topics: Animals; Caffeine; Calcimycin; Calcium; Chick Embryo; Eye; Microscopy, Fluorescence; Organ Culture Techniques; Retina; Theophylline; Trifluoperazine; Verapamil

1982
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; Mice; Mice, Inbred ICR; Theobromine; Theophylline; Urethane; Xanthines

1983
Theophylline-induced potentiation of the antinociceptive action of baclofen.
    British journal of pharmacology, 1983, Volume: 78, Issue:2

    Topics: Analgesics; Animals; Baclofen; Caffeine; Drug Synergism; Male; Rats; Rats, Inbred Strains; Reaction Time; Theophylline

1983
New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities.
    Pharmacological research communications, 1983, Volume: 15, Issue:2

    Topics: Adipose Tissue; Animals; Caffeine; In Vitro Techniques; Lipolysis; Male; Norepinephrine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Theophylline

1983
Disposition of caffeine and its metabolites in man.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:1

    Topics: Adult; Biotransformation; Caffeine; Female; Humans; Kinetics; Male; Theobromine; Theophylline

1983
Is theophylline, aminophylline, or caffeine (methylxanthines) contraindicated in malignant hyperthermia susceptible patients?
    Anesthesia and analgesia, 1983, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aminophylline; Caffeine; Child; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Theophylline; Xanthines

1983
Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:3

    Topics: Apnea; Caffeine; Gestational Age; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline; Xanthines

1983
Plasma xanthine levels in premature infants treated for apnoea with theophylline.
    Journal of clinical and hospital pharmacy, 1983, Volume: 8, Issue:2

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline; Xanthines

1983
Crystalline anhydrous-hydrate phase changes of caffeine and theophylline in solvent-water mixtures.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:7

    Topics: Caffeine; Chemical Phenomena; Chemistry; Solubility; Solvents; Theophylline; Water

1983
Inhibitory effects of methylxanthines on the activity of xanthine oxidase.
    Life sciences, 1980, Dec-01, Volume: 27, Issue:22

    Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines

1980
Regulation of human drug metabolism by dietary factors.
    Ciba Foundation symposium, 1980, Volume: 76

    Topics: Adult; Antipyrine; Biotransformation; Caffeine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Half-Life; Humans; Metabolic Clearance Rate; Oxidation-Reduction; Pharmaceutical Preparations; Theobromine; Theophylline; Vegetables

1980
Apnea associated with theophylline withdrawal in a term neonate.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:1

    Topics: Apnea; Caffeine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregnancy; Substance Withdrawal Syndrome; Theophylline

1982
Placental theophylline transfer in pregnant asthmatics.
    JAMA, 1982, Feb-12, Volume: 247, Issue:6

    Topics: Adolescent; Adult; Asthma; Caffeine; Female; Fetal Blood; Fetus; Half-Life; Heart; Hemodynamics; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Complications; Theophylline

1982
Metabolism and distribution of labeled theophylline in the pregnant rat. Impairment of theophylline metabolism by pregnancy and absence of a blood-brain barrier in the fetus.
    Pediatric research, 1982, Volume: 16, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Theophylline; Tissue Distribution

1982
Inhibition by theophylline of the early component of canine ventricular contraction.
    The American journal of physiology, 1982, Volume: 242, Issue:3

    Topics: Animals; Caffeine; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Stimulation, Chemical; Theophylline; Time Factors; Ventricular Function

1982
Effects of caffeine, theophylline and theobromine on scheduled controlled responding in rats.
    British journal of pharmacology, 1982, Volume: 75, Issue:3

    Topics: Animals; Behavior, Animal; Caffeine; Conditioning, Operant; Male; Rats; Rats, Inbred Strains; Reinforcement Schedule; Theobromine; Theophylline; Xanthines

1982
Effects of methylxanthines on superprecipitation of myosin B extracted from rabbit fast skeletal muscle.
    Journal of biochemistry, 1982, Volume: 91, Issue:2

    Topics: Animals; Caffeine; Chemical Precipitation; Muscle Proteins; Muscles; Myosins; Rabbits; Solubility; Theobromine; Theophylline; Xanthines

1982
Sensitivity changes after morphine treatment in the mouse uterus.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 255, Issue:1

    Topics: Acetylcholine; Animals; Caffeine; Calcium; Drug Tolerance; Female; In Vitro Techniques; Mice; Morphine; Naloxone; Serotonin; Theophylline; Uterine Contraction

1982
Low-frequency fatigue in isolated skeletal muscles and the effects of methylxanthines.
    Clinical science (London, England : 1979), 1982, Volume: 63, Issue:2

    Topics: Animals; Caffeine; Female; Mice; Muscle Contraction; Muscles; Theophylline; Xanthines

1982
Sister chromatid exchanges induced by methylxanthines contained in coffee, tea and cocoa.
    Experientia, 1982, May-15, Volume: 38, Issue:5

    Topics: Animals; Bone Marrow; Caffeine; Coca; Coffee; Cricetinae; Cricetulus; Crossing Over, Genetic; Plants, Medicinal; Sister Chromatid Exchange; Tea; Theobromine; Theophylline; Xanthines

1982
Massive catecholamine release from caffeine poisoning.
    JAMA, 1982, Sep-03, Volume: 248, Issue:9

    Topics: Adult; Affective Symptoms; Caffeine; Catecholamines; Female; Humans; Hyperglycemia; Hyperventilation; Hypokalemia; Ketone Bodies; Theophylline

1982
Cross validation of serum to saliva relationships of caffeine, theophylline and total methylxanthines in neonates.
    Developmental pharmacology and therapeutics, 1982, Volume: 4, Issue:1-2

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Saliva; Theophylline; Xanthines

1982
Improved high-performance liquid chromatographic assay for theophylline in plasma and saliva in the presence of caffeine and its metabolites and comparisons with three other assays.
    Journal of chromatography, 1982, Aug-13, Volume: 231, Issue:1

    Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Humans; Saliva; Theophylline

1982
[Pharmacologic effects of caffeine and theophylline in the premature infant].
    Developmental pharmacology and therapeutics, 1982, Volume: 4 Suppl

    Topics: Caffeine; Glucose; Growth; Hormones; Humans; Infant, Newborn; Infant, Premature; Respiration; Theophylline; Xanthines

1982
[Use of caffeine in the treatment of apnea in premature infants].
    Developmental pharmacology and therapeutics, 1982, Volume: 4 Suppl

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Theophylline; Time Factors

1982
Reversed-phase liquid chromatographic investigation of UV-absorbing low-molecular-weight compounds in saliva.
    Journal of chromatography, 1982, Dec-10, Volume: 233

    Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Molecular Weight; Saliva; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Time Factors

1982
Effect of serum caffeine level on pneumocardiogram of premature infants treated for apnea with theophylline.
    Medical hypotheses, 1982, Volume: 9, Issue:6

    Topics: Apnea; Caffeine; Electrocardiography; False Negative Reactions; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Respiration; Theophylline

1982
Effect of caffeine, theophylline and nicotine on D-glucose and folate transport in rat jejunal brush border membrane vesicles.
    The International journal of biochemistry, 1982, Volume: 14, Issue:12

    Topics: Animals; Biological Transport; Caffeine; Folic Acid; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Microvilli; Nicotine; Rats; Rats, Inbred Strains; Theophylline

1982
Caffeine and theophylline: serum/CSF correlation in premature infants.
    The Journal of pediatrics, 1980, Volume: 96, Issue:6

    Topics: Apnea; Blood-Brain Barrier; Caffeine; Chromatography, Liquid; Humans; Infant, Newborn; Infant, Premature, Diseases; Theophylline; Xanthines

1980
Development of tolerance to dopaminergic stimulating effect of theophylline in mice with unilateral striatal 6-hydroxydopamine lesions.
    European journal of pharmacology, 1982, Apr-08, Volume: 79, Issue:1-2

    Topics: Animals; Caffeine; Corpus Striatum; Drug Tolerance; Humans; Hydroxydopamines; Levodopa; Male; Mice; Receptors, Dopamine; Stereotyped Behavior; Theophylline

1982
Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.
    FEBS letters, 1982, May-17, Volume: 141, Issue:2

    Topics: Acetylcholinesterase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Carbamoyl-Phosphate Synthase (Ammonia); Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Lesch-Nyhan Syndrome; Liver; Ornithine Carbamoyltransferase; Rats; Theophylline; Urea

1982
Pharmacologic considerations in the therapy of neonatal apnea.
    Pediatric clinics of North America, 1981, Volume: 28, Issue:1

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Monitoring, Physiologic; Theophylline

1981
Theophylline metabolism during the first month of life and development.
    Pediatric research, 1981, Volume: 15, Issue:4 Pt 1

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Kidney; Male; Theophylline; Xanthines

1981
Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man.
    Toxicology letters, 1981, Volume: 7, Issue:3

    Topics: Adult; Animals; Biotransformation; Caffeine; Humans; Macaca fascicularis; Male; Rats; Species Specificity; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines

1981
In vivo N7 methylation of theophylline to caffeine in premature infants. Studies with use of stable isotopes.
    Developmental pharmacology and therapeutics, 1981, Volume: 2, Issue:3

    Topics: Caffeine; Carbon Isotopes; Humans; Infant, Newborn; Infant, Premature; Methylation; Nitrogen Isotopes; Phenobarbital; Theophylline; Time Factors

1981
Determination of plasma theophylline by straight-phase high-performance liquid chromatography: elimination of interfering caffeine metabolites.
    Journal of chromatography, 1981, Mar-13, Volume: 222, Issue:3

    Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Humans; Microchemistry; Theophylline

1981
Effect of caffeine on circulating theophylline levels in beagle dogs.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:4

    Topics: Aminophylline; Animals; Caffeine; Dogs; Female; Injections, Intravenous; Kinetics; Male; Theophylline

1981
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
    Brain research, 1981, Jun-01, Volume: 213, Issue:2

    Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath; Organ Size; Rats; Theophylline

1981
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:6

    Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factors; Species Specificity; Theophylline; Xanthines

1981
[Effect of methylxanthines on urinary prostaglandin E excretion of rats acutely loaded with salt and water (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 77, Issue:4

    Topics: Animals; Caffeine; Diuresis; Electrolytes; Isotonic Solutions; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium Chloride; Theobromine; Theophylline; Water

1981
Extended Hildebrand Solubility Approach: methylxanthines in mixed solvents.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:10

    Topics: Caffeine; Chemical Phenomena; Chemistry, Physical; Dioxanes; Solubility; Solvents; Theobromine; Theophylline; Water; Xanthines

1981
Developmental pharmacology of the methylxanthines. Introduction.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Animals; Caffeine; Humans; Theophylline

1981
Conversion of theophylline to caffeine by the human fetus.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Amniotic Fluid; Caffeine; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Infant, Premature; Mass Spectrometry; Pregnancy; Theophylline

1981
Studies of caffeine and theophylline in the neonate.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Aminophylline; Amniotic Fluid; Birth Weight; Blood Transfusion; Caffeine; Fetal Blood; Fetus; Gestational Age; Humans; Infant, Newborn; Theophylline

1981
Methylxanthines in serum, saliva, and spinal fluid of premature infants.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kinetics; Saliva; Theophylline

1981
Adverse effects of caffeine and theophylline in the newborn infant.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Apnea; Asphyxia Neonatorum; Caffeine; Cardiovascular System; Central Nervous System; Digestive System; Hormones; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kidney; Retina; Theophylline

1981
Excretion of methylxanthines in human milk.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Adult; Beverages; Caffeine; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Kinetics; Lactation; Milk, Human; Pregnancy; Saliva; Theobromine; Theophylline

1981
Effects of methylxanthines on urinary prostaglandin E excretion in rats.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:2

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electrolytes; Indomethacin; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1981
Binding of xanthine derivatives to human serum albumin as a function of pH.
    Acta pharmaceutica Suecica, 1981, Volume: 18, Issue:6

    Topics: Blood; Caffeine; Humans; Hydrogen-Ion Concentration; Serum Albumin; Theophylline

1981
Twitch potentiation by rest in canine ventricular muscle: effects of theophylline.
    The American journal of physiology, 1981, Volume: 241, Issue:4

    Topics: Action Potentials; Animals; Caffeine; Calcium; Dogs; Epinephrine; Female; Gallopamil; Heart; In Vitro Techniques; Lanthanum; Male; Manganese; Myocardium; Papillary Muscles; Theophylline; Ventricular Function

1981
Subchronic administration of caffeine and theophylline in drinking water: effects on rat liver RNA polymerase I activity.
    Drug and chemical toxicology, 1981, Volume: 4, Issue:2

    Topics: Animals; Caffeine; DNA-Directed RNA Polymerases; Drinking; Hypertrophy; Liver; Male; Rats; Rats, Inbred Strains; RNA Polymerase I; Theophylline

1981
Reversed-phase high-performance liquid chromatographic determination of caffeine and its N-demethylated metabolites in dog plasma.
    Journal of chromatography, 1981, Nov-13, Volume: 226, Issue:1

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Dogs; Male; Reference Values; Theobromine; Theophylline; Time Factors

1981
Metabolism of theophylline to caffeine in adults.
    Research communications in chemical pathology and pharmacology, 1981, Volume: 34, Issue:3

    Topics: Adult; Biotransformation; Caffeine; Humans; Kinetics; Male; Mathematics; Theophylline

1981
[Pharmacokinetics of theophylline and caffeine in premature infants with apnea (author's transl)].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1981, Volume: 129, Issue:12

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinetics; Protein Binding; Theophylline

1981
Complex interactions of caffeine and its structural analogs with ultraviolet light in cell killing.
    Mutation research, 1981, Volume: 84, Issue:1

    Topics: Animals; Caffeine; Cell Line; Cell Survival; Embryo, Mammalian; Mice; Mice, Inbred C3H; Theophylline; Ultraviolet Rays; Xanthines

1981
Use of salivary concentrations in the prediction of serum caffeine and theophylline concentrations in premature infants.
    The Journal of pediatrics, 1980, Volume: 96, Issue:3 Pt 1

    Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Regression Analysis; Saliva; Theophylline

1980
Separation and quantitation of theophylline and paraxanthine by reversed-phase liquid chromatography.
    Clinical chemistry, 1980, Volume: 26, Issue:3

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Quaternary Ammonium Compounds; Theophylline

1980
A study of caffeine in tea.
    The American journal of clinical nutrition, 1980, Volume: 33, Issue:5

    Topics: Caffeine; Methods; Tea; Theobromine; Theophylline

1980
Charge transfer effect through hydrogen bonding in caffeine-p-cresol and theophylline-p-cresol complexes.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:5

    Topics: Caffeine; Chemical Phenomena; Chemistry; Cresols; Drug Interactions; Hydrogen Bonding; Spectrophotometry, Infrared; Theophylline

1980
Relationship between morphological transformation and [3H]thymidine incorporation stimulated by a chemical carcinogen in postconfluent cultures of hamster embryo cells.
    Cancer research, 1980, Volume: 40, Issue:7

    Topics: Animals; Autoradiography; Caffeine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Hydroxyurea; Mesocricetus; Methylnitronitrosoguanidine; Stimulation, Chemical; Theophylline; Thymidine

1980
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
    Biochemical pharmacology, 1980, Jul-01, Volume: 29, Issue:13

    Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines

1980
Effects of caffeine and other substances on sodium- and calcium-independent efflux in cyanide poisoned goldfish ventricles.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 244, Issue:2

    Topics: Animals; Biological Transport, Active; Caffeine; Calcium; Cyanides; Goldfish; In Vitro Techniques; Myocardium; Naphazoline; Quinidine; Sarcoplasmic Reticulum; Theophylline

1980
Caffeine reversal of length-dependent changes in myocardial contractile state in the cat.
    Circulation research, 1980, Volume: 47, Issue:4

    Topics: Animals; Caffeine; Calcium; Cats; Dose-Response Relationship, Drug; Manganese; Myocardial Contraction; Theophylline; Time Factors; Verapamil

1980
Effect of age on patterns of theophylline metabolism.
    Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:4

    Topics: Adult; Age Factors; Aged; Biotransformation; Caffeine; Child; Child, Preschool; Cytochrome P-450 Enzyme System; Female; Humans; Infant, Newborn; Infant, Premature; Male; Metabolic Clearance Rate; Middle Aged; Regression Analysis; Theophylline

1980
Study of theophylline metabolism in premature human newborns using stable isotope labelling.
    Biomedical mass spectrometry, 1980, Volume: 7, Issue:5

    Topics: Biotransformation; Caffeine; Carbon Isotopes; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Premature; Theophylline

1980
The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography.
    Clinical biochemistry, 1980, Volume: 13, Issue:3

    Topics: Adult; Caffeine; Child; Chromatography, High Pressure Liquid; Humans; Theobromine; Theophylline

1980
[The mechanism of the chronotropic effect of caffeine and theophylline in guinea pigs].
    Arhiv za higijenu rada i toksikologiju, 1980, Volume: 31, Issue:2

    Topics: Animals; Caffeine; Guinea Pigs; Heart Rate; In Vitro Techniques; Methyldopa; Propranolol; Reserpine; Theophylline

1980
Simultaneous determination of theophylline and caffeine after extractive alkylation in small volumes of plasma by gas chromatography--mass spectrometry.
    Journal of chromatography, 1980, Nov-14, Volume: 221, Issue:1

    Topics: Alkylation; Apnea; Caffeine; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Theophylline

1980
Simultaneous determination of dyphylline and theophylline in human plasma by high-performance liquid chromatography.
    Journal of chromatography, 1980, Nov-14, Volume: 221, Issue:1

    Topics: Asthma; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Reference Values; Theobromine; Theophylline

1980
Characterization of the methylxanthine-induced propagated wave phenomenon in striated muscle.
    The Journal of experimental zoology, 1980, Volume: 212, Issue:3

    Topics: Animals; Caffeine; Chick Embryo; Halothane; Histocytochemistry; Muscle Contraction; Muscles; Quinine; Theobromine; Theophylline

1980
Caffeine- and aminophylline-induced seizures.
    Epilepsia, 1981, Volume: 22, Issue:1

    Topics: Aminophylline; Animals; Arrhythmias, Cardiac; Caffeine; Cerebral Cortex; Electrocardiography; Electroencephalography; Ethylenediamines; Injections, Intraperitoneal; Rats; Seizures; Theophylline; Time Factors

1981
Histamine-evoked Ca2+ oscillations in HeLa cells are sensitive to methylxanthines but insensitive to ryanodine.
    Pflugers Archiv : European journal of physiology, 1994, Volume: 426, Issue:1-2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biological Clocks; Caffeine; Calcium; Colforsin; HeLa Cells; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Intracellular Fluid; Ruthenium Red; Ryanodine; Theophylline

1994
Caffeine-induced calcium oscillations in heavy-sarcoplasmic-reticulum vesicles from rabbit skeletal muscle.
    European journal of biochemistry, 1994, Apr-01, Volume: 221, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Hydrogen-Ion Concentration; Magnesium Chloride; Muscle Proteins; Muscles; Neomycin; Osmolar Concentration; Osmotic Pressure; Rabbits; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Temperature; Theophylline

1994
Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells.
    Experimental cell research, 1994, Volume: 212, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Atropine; Caffeine; Calcium; Carbachol; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Gene Expression; Hydrogen-Ion Concentration; Interferon-gamma; Ionomycin; Mice; Nitric Oxide Synthase; Rats; Recombinant Proteins; RNA, Messenger; Signal Transduction; Terpenes; Thapsigargin; Theophylline; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Xanthines

1994
The effect of caffeine on prostaglandin output from the guinea-pig uterus.
    British journal of pharmacology, 1994, Volume: 113, Issue:1

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calmodulin; Female; Gallic Acid; Guinea Pigs; Prostaglandins; Ruthenium Red; Ryanodine; Stimulation, Chemical; Sulfonamides; Theophylline; Trifluoperazine; Uterus; Vasodilator Agents

1994
IBMX induces calcium release from intracellular stores in rat sensory neurones.
    Cell calcium, 1995, Volume: 17, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline

1995
Tricyclic theophylline derivatives with high water-solubility: structure-activity relationships at adenosine receptors, phosphodiesterases, and benzodiazepine binding sites.
    Die Pharmazie, 1995, Volume: 50, Issue:5

    Topics: Animals; Binding, Competitive; Caffeine; GABA-A Receptor Antagonists; Guanosine Triphosphate; In Vitro Techniques; Membranes; Phenylisopropyladenosine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P1; Solubility; Structure-Activity Relationship; Theophylline

1995
Effects of methylxanthine derivatives on adriamycin concentration and antitumor activity.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:6

    Topics: Animals; Caffeine; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Synergism; Male; Mice; Pentoxifylline; Theobromine; Theophylline

1995
Interference by caffeine in theophylline measurement.
    Annals of clinical biochemistry, 1995, Volume: 32 ( Pt 3)

    Topics: Caffeine; Cross Reactions; Immunoassay; Theophylline

1995
Interference by caffeine in polarization fluoroimmunoassays for theophylline.
    Annals of clinical biochemistry, 1995, Volume: 32 ( Pt 3)

    Topics: Caffeine; Cross Reactions; Fluorescence Polarization Immunoassay; Theophylline

1995
Evidence for a protective effect of theophylline and caffeine on cyclosporine-induced contractions in two in vitro glomerular models.
    Transplantation proceedings, 1995, Volume: 27, Issue:4

    Topics: Animals; Caffeine; Cyclosporine; Dose-Response Relationship, Drug; Glomerular Mesangium; In Vitro Techniques; Kidney Glomerulus; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors

1995
Highly sensitive and rapid determination of theophylline, theobromine and caffeine in human plasma and urine by gradient capillary high-performance liquid chromatography-frit-fast atom bombardment mass spectrometry.
    Journal of chromatography. B, Biomedical applications, 1995, May-19, Volume: 667, Issue:2

    Topics: Caffeine; Capillary Action; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Fast Atom Bombardment; Theobromine; Theophylline

1995
Influences of immobilization and footshock stress on pharmacokinetics of theophylline and caffeine in rats.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:6

    Topics: Animals; Caffeine; Electroshock; Half-Life; Immobilization; Intestinal Absorption; Male; Rats; Rats, Wistar; Stress, Psychological; Theophylline

1995
Multiple effects of caffeine on calcium current in rat ventricular myocytes.
    Pflugers Archiv : European journal of physiology, 1993, Volume: 424, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium Channels; Egtazic Acid; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Theophylline

1993
Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995, Volume: 4, Issue:2

    Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Male; Middle Aged; Oxidoreductases; Phenotype; Spectrophotometry, Ultraviolet; Theophylline; Time Factors; Uracil; Xanthines

1995
Effects of xanthine derivatives in a light/dark test in mice and the contribution of adenosine receptors.
    Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:9

    Topics: Adenosine; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Interactions; Light; Male; Mice; Phenethylamines; Purinergic P1 Receptor Antagonists; Structure-Activity Relationship; Theophylline; Xanthines

1994
[Mutagenesis, antimutagenesis and the cellular regulatory system].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:1

    Topics: Adenosine; Antimutagenic Agents; Caffeine; Colchicine; Cyclic AMP; Mutagenesis; Plant Cells; Plants; Seeds; Theophylline

1995
Development of bioreductive markers for tumour hypoxia.
    Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:3

    Topics: Animals; Antibodies; Antibodies, Monoclonal; Caffeine; Carcinoma; Cell Division; Cell Hypoxia; Cell Line; DNA, Neoplasm; Mice; Mice, Inbred CBA; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Theophylline; Tumor Cells, Cultured

1995
Predictive steady-state chromatography. 1. Algorithms for leading and trailing edges of resolved and unresolved peaks in liquid chromatography.
    Analytical chemistry, 1994, Nov-01, Volume: 66, Issue:21

    Topics: Algorithms; Caffeine; Chromatography, Liquid; Computer Simulation; Models, Theoretical; Reproducibility of Results; Theophylline

1994
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; Glutathione Transferase; Glyoxal; Liver; Liver Neoplasms; Male; Organ Size; Pyruvaldehyde; Rats; Rats, Inbred F344; Theobromine; Theophylline

1995
Influence of calcium on the effects of okadaic acid and its interaction with caffeine and theophylline in rat myometrium.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:3

    Topics: Animals; Caffeine; Calcium; Colforsin; Drug Interactions; Ethers, Cyclic; Extracellular Space; Female; Intracellular Fluid; Myometrium; Okadaic Acid; Papaverine; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors; Uterine Contraction

1994
[Involvement of purines in analgesia produced by weak electro-acupuncture].
    Zhen ci yan jiu = Acupuncture research, 1994, Volume: 19, Issue:1

    Topics: Acupuncture Analgesia; Animals; Caffeine; Dipyridamole; Electroacupuncture; Pain Threshold; Purinergic P1 Receptor Antagonists; Rats; Spinal Cord; Theophylline

1994
Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells.
    Radiation research, 1995, Volume: 141, Issue:3

    Topics: 2-Aminopurine; Animals; Apoptosis; Caffeine; DNA Damage; Dose-Response Relationship, Radiation; G2 Phase; Kinetics; Linear Energy Transfer; Lymphoma, T-Cell; Mice; Mitosis; Theobromine; Theophylline; Tumor Cells, Cultured

1995
Determination of xanthines by high-performance liquid chromatography and thin-layer chromatography in horse urine after ingestion of Guaraná powder.
    The Analyst, 1994, Volume: 119, Issue:12

    Topics: Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Combinations; Horses; Regression Analysis; Reproducibility of Results; Seeds; Theobromine; Theophylline; Xanthines

1994
Effects of caffeine and related methylxanthines on fetal mouse palates cultured in vitro.
    The Journal of toxicological sciences, 1994, Volume: 19, Issue:4

    Topics: Animals; Caffeine; Chi-Square Distribution; Female; Male; Mice; Mice, Inbred ICR; Organ Culture Techniques; Palate; Theobromine; Theophylline; Xanthines

1994
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
    Journal of cellular biochemistry, 1994, Volume: 56, Issue:4

    Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Female; Liver Neoplasms, Experimental; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains; Survival; Theophylline; Tretinoin

1994
Microdialysis sampling coupled on-line to fast microbore liquid chromatography.
    Journal of chromatography. A, 1995, Feb-03, Volume: 691, Issue:1-2

    Topics: Acetaminophen; Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline

1995
Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:12

    Topics: Adenosine; Animals; Bronchodilator Agents; Caffeine; Calcium; Culture Media; Dantrolene; Diaphragm; Electric Stimulation; Extracellular Space; Female; Guinea Pigs; Immunization; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Serum Albumin, Bovine; Theobromine; Theophylline; Verapamil; Xanthines

1993
[Development of the method for analysis of theophylline and its related compounds using capillary high-performance liquid chromatography/fast atom bombardment-mass spectrometry].
    Nihon hoigaku zasshi = The Japanese journal of legal medicine, 1994, Volume: 48, Issue:4

    Topics: Caffeine; Chromatography, High Pressure Liquid; Hair; Humans; Spectrometry, Mass, Fast Atom Bombardment; Theobromine; Theophylline

1994
Paraxanthine (metabolite of caffeine) mimics caffeine's interaction with sympathetic control of thermogenesis.
    The American journal of physiology, 1994, Volume: 267, Issue:5 Pt 1

    Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Caffeine; Drug Combinations; Ephedrine; Male; Osmolar Concentration; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Theophylline

1994
Complexity of adjunctive pharmacological agents in ECT.
    The American journal of psychiatry, 1994, Volume: 151, Issue:10

    Topics: Caffeine; Electroconvulsive Therapy; Humans; Theophylline

1994
Protection against methamphetamine-induced neurotoxicity to neostriatal dopaminergic neurons by adenosine receptor activation.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; MPTP Poisoning; Receptors, Purinergic P1; Theophylline; Tyrosine 3-Monooxygenase

1994
A caffeine- and ryanodine-sensitive intracellular Ca2+ store can act as a Ca2+ source and a Ca2+ sink in PC12 cells.
    The Biochemical journal, 1994, Jun-01, Volume: 300 ( Pt 2)

    Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Proteins; PC12 Cells; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel; Theophylline

1994
Comparison of the effects of caffeine and other methylxanthines on [Ca2+]i in rat ventricular myocytes.
    British journal of pharmacology, 1994, Volume: 111, Issue:2

    Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Chemical Phenomena; Chemistry, Physical; Fluorescent Dyes; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Myocardium; Rats; Solubility; Theobromine; Theophylline; Xanthines

1994
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.
    Genetic epidemiology, 1994, Volume: 11, Issue:2

    Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines

1994
The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine.
    British journal of pharmacology, 1994, Volume: 111, Issue:3

    Topics: Animals; Caffeine; Calcium Chloride; Cold Temperature; Drug Interactions; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Muscle, Smooth; Phorbol Esters; Potassium; Ryanodine; Theophylline; Trachea; Verapamil; Xanthines

1994
Stress and adenosine: I. Effect of methylxanthine and amphetamine stimulants on learned helplessness in rats.
    Behavioral neuroscience, 1994, Volume: 108, Issue:2

    Topics: Amphetamine; Animals; Arousal; Avoidance Learning; Caffeine; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Fear; Helplessness, Learned; Male; Premedication; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Purinergic P1; Stress, Psychological; Theophylline

1994
Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning.
    European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Avoidance Learning; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Theophylline; Vasodilator Agents

1994
Intracellular signal transduction mechanisms of rat epididymal spermatozoa and their relationship to motility and metabolism.
    Molecular reproduction and development, 1994, Volume: 38, Issue:1

    Topics: Animals; Bicarbonates; Caffeine; Calcium; Carbon Dioxide; Epididymis; Glucose; In Vitro Techniques; Intracellular Fluid; Male; Nucleotides, Cyclic; Rats; Rats, Wistar; Signal Transduction; Sperm Motility; Spermatozoa; Theophylline

1994
Interference by caffeine in polarization fluoroimmunoassays for theophylline in external quality assurance samples.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 3)

    Topics: Artifacts; Caffeine; Fluorescence Polarization Immunoassay; Quality Control; Theophylline

1994
Role of adenosine in the hypoxic ventilatory response of the newborn piglet.
    Pediatric pulmonology, 1994, Volume: 17, Issue:1

    Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Cerebrospinal Fluid; Citrates; Dipyridamole; Drug Combinations; Hypoxia; Oxygen; Purinergic P1 Receptor Antagonists; Respiration; Swine; Theophylline

1994
Hepatic glutathione and lipid peroxidation in rats treated with theophylline. Effect of dose and combination with caffeine and acetaminophen.
    Biochemical pharmacology, 1994, Feb-09, Volume: 47, Issue:3

    Topics: Acetaminophen; Animals; Caffeine; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Liver; Male; Rats; Theophylline

1994
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.
    Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:12

    Topics: Administration, Oral; Animals; Caffeine; Endotoxins; Fever; Injections, Intravenous; Malaria; Male; Metabolic Clearance Rate; Plasmodium berghei; Rats; Rats, Wistar; Theobromine; Theophylline

1993
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.
    Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid

1994
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms.
    Biochemical pharmacology, 1994, May-18, Volume: 47, Issue:10

    Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Theobromine; Theophylline; Uric Acid

1994
Alterations in theophylline metabolism during the first year of life.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:4

    Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Clearance Rate; Theophylline

1993
Effect of adenosine blockade on plasma renin activity and catecholamines.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1993, Volume: 17, Issue:1

    Topics: Adenosine; Animals; Blood Pressure; Caffeine; Consciousness; Epinephrine; Hydralazine; Kidney; Male; Norepinephrine; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renin; Renin-Angiotensin System; Secretory Rate; Sodium, Dietary; Theophylline; Xanthines

1993
Accumulation of theophylline, theobromine and paraxanthine in the fetal rat brain following a single oral dose of caffeine.
    Brain research. Developmental brain research, 1993, Oct-15, Volume: 75, Issue:2

    Topics: Animals; Biotransformation; Brain; Caffeine; Chromatography, High Pressure Liquid; Female; Pregnancy; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines

1993
Caffeine inhibits agonists-induced cytoplasmic Ca2+ oscillations in single rat hepatocytes.
    Biochemical and biophysical research communications, 1994, Jan-28, Volume: 198, Issue:2

    Topics: Aequorin; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Inositol 1,4,5-Trisphosphate Receptors; Liver; Male; Periodicity; Phenylephrine; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine; Theophylline; Vasopressins

1994
Caffeine tolerance in Schizosaccharomyces pombe: physiological adaptation and interaction with theophylline.
    Canadian journal of microbiology, 1993, Volume: 39, Issue:5

    Topics: Adaptation, Physiological; Caffeine; Cell Division; Drug Interactions; Schizosaccharomyces; Theophylline

1993
Enhancement of the behavioral toxicity induced by combined administration of ethanol with methylxanthines: evaluation by discrete avoidance in mice.
    The Journal of toxicological sciences, 1993, Volume: 18, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Caffeine; Drug Synergism; Ethanol; Male; Mice; Mice, Inbred Strains; Theobromine; Theophylline; Xanthines

1993
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices.
    Neuroscience letters, 1993, Jun-11, Volume: 155, Issue:2

    Topics: Action Potentials; Adenosine; Animals; Caffeine; Cell Hypoxia; Energy Metabolism; Evoked Potentials; Glucose; Glyburide; Hippocampus; Hypoglycemia; Neural Inhibition; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Tolbutamide

1993
Effects of caffeine and PD 116,600 on the differential-reinforcement-of-low rate 72-S (DRL 72-S) schedule of reinforcement.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: Animals; Antidepressive Agents; Caffeine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Theophylline

1993
Pharmacological modulation of the spasmogenic response to methylxanthines in guinea-pig trachea.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 79, Issue:1

    Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Protein Kinase C; Sodium; Theophylline; Trachea; Xanthines

1993
Comparison of hepatic drug-oxidizing activity after simultaneous administration of two probe drugs, caffeine and trimethadione, to human subjects.
    Pharmacology & toxicology, 1993, Volume: 72, Issue:1

    Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Half-Life; Humans; Liver; Male; Middle Aged; Oxidation-Reduction; Oxygenases; Theobromine; Theophylline; Trimethadione

1993
Excretion of caffeine and its primary degradation products into bile.
    Journal of hepatology, 1993, Volume: 17, Issue:1

    Topics: Adult; Aged; Bile; Bilirubin; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Theobromine; Theophylline; Time Factors

1993
Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels. 1. Polymer composition.
    Journal of biomaterials science. Polymer edition, 1993, Volume: 4, Issue:3

    Topics: Aminophylline; Biocompatible Materials; Caffeine; Diffusion; Drug Carriers; Drug Delivery Systems; Gels; Models, Chemical; Morphine; Polyethylene Glycols; Polyurethanes; Solubility; Theophylline; Water

1993
Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:3

    Topics: Administration, Oral; Adult; Caffeine; Drug Administration Schedule; Drug Interactions; Eating; Humans; Male; Middle Aged; Theophylline

1993
HPLC determination of caffeine and theophylline by direct serum injection.
    Clinical chemistry, 1993, Volume: 39, Issue:6

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline

1993
Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes.
    Clinical and diagnostic laboratory immunology, 1995, Volume: 2, Issue:6

    Topics: Caffeine; Cytokines; Dexamethasone; Glucocorticoids; Humans; Interleukin-1; Interleukin-10; Leukocytes; Pentoxifylline; Streptococcus pneumoniae; Theophylline; Tumor Necrosis Factor-alpha; Xanthines

1995
Adenosine antagonists potentiate D2 dopamine-dependent activation of Fos in the striatopallidal pathway.
    Neuroscience, 1995, Volume: 68, Issue:3

    Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Caffeine; Dopamine Agonists; Ergolines; Genes, fos; Globus Pallidus; Immunohistochemistry; Male; Neostriatum; Neural Pathways; Phosphodiesterase Inhibitors; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reserpine; Theobromine; Theophylline

1995
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:10

    Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline

1995
The effects of theophylline and caffeine on the isolated rat diaphragm.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1995, Volume: 45, Issue:2

    Topics: Animals; Caffeine; Diaphragm; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle Fatigue; Rats; Theophylline

1995
Caffeine-induced oscillations of cytosolic Ca2+ in GH3 pituitary cells are not due to Ca2+ release from intracellular stores but to enhanced Ca2+ influx through voltage-gated Ca2+ channels.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 431, Issue:3

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Line; Cytosol; Enzyme Inhibitors; Intracellular Fluid; Ion Channel Gating; Ionomycin; Phosphodiesterase Inhibitors; Pituitary Gland, Anterior; Rats; Terpenes; Thapsigargin; Theophylline

1996
Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Glutathione; Imines; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Theophylline

1996
Drug-protein interactions: two-site binding of heterocyclic ligands to a monomeric hemoglobin.
    Journal of inorganic biochemistry, 1996, May-15, Volume: 62, Issue:3

    Topics: Binding Sites; Caffeine; Hemoglobins; Kinetics; Ligands; Molecular Structure; Protein Binding; Purines; Theophylline; Thermodynamics

1996
Purine suppression of proliferation of Sertoli-like TM4 cells in culture.
    Cell proliferation, 1995, Volume: 28, Issue:12

    Topics: Adenosine; Animals; Caffeine; Cell Division; Cells, Cultured; Male; Mice; Purinergic P1 Receptor Antagonists; Purines; Receptors, Purinergic P1; Sertoli Cells; Theobromine; Theophylline

1995
Anxiolytic activity of adenosine receptor activation in mice.
    British journal of pharmacology, 1995, Volume: 116, Issue:3

    Topics: Adenosine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Male; Maze Learning; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline

1995
Inhibitors in tea of intestinal absorption of phenylalanine in rats.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1996, Volume: 113, Issue:1

    Topics: Analysis of Variance; Animals; Caffeine; Cyclic AMP; Hydrolyzable Tannins; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Phenylalanine; Phosphodiesterase Inhibitors; Plant Extracts; Rats; Sodium-Potassium-Exchanging ATPase; Tea; Theophylline

1996
Effect of prostaglandin F2 alpha and methylxanthines on enzymic release of bull epididymal spermatozoa in vitro.
    Contraception, 1996, Volume: 53, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Cattle; Dinoprost; Epididymis; Male; Sperm Motility; Spermatozoa; Theophylline; Xanthines

1996
Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma.
    Journal of chromatography. B, Biomedical applications, 1996, Mar-03, Volume: 677, Issue:2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline

1996
Pharmacokinetics of caffeine in the oestrogen-implanted ovariectomized ewe.
    Journal of veterinary pharmacology and therapeutics, 1996, Volume: 19, Issue:2

    Topics: Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Estrus Synchronization; Female; Half-Life; Injections, Intravenous; Ovariectomy; Sheep; Theobromine; Theophylline

1996
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.
    British journal of pharmacology, 1996, Volume: 118, Issue:2

    Topics: 2-Chloroadenosine; Animals; Caffeine; Hemodynamics; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline

1996
Adenosine A2 receptor-mediated modulation of contralateral rotation induced by metabotropic glutamate receptor activation.
    European journal of pharmacology, 1995, Dec-12, Volume: 287, Issue:2

    Topics: Animals; Behavior, Animal; Caffeine; Cycloleucine; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Rotation; Theophylline

1995
Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15

    Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cyclic AMP; Fungal Proteins; Genes, Fungal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Polymerase Chain Reaction; RNA Viruses; RNA, Fungal; RNA, Messenger; Signal Transduction; Theophylline; Transcription, Genetic; Virulence; Virus Replication; Xylariales

1996
Assessment of dimethylxanthine formation from caffeine in healthy adults: comparison between plasma and saliva concentrations and urinary excretion of metabolites.
    Scandinavian journal of clinical and laboratory investigation, 1996, Volume: 56, Issue:3

    Topics: Adult; Caffeine; Female; Humans; Male; Saliva; Theobromine; Theophylline

1996
Simultaneous presence of cAMP and cGMP exert a co-ordinated inhibitory effect on the agonist-evoked Ca2+ signal in pancreatic acinar cells.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:5

    Topics: Acetylcholine; Animals; Caffeine; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Mice; Pancreas; Papaverine; Phosphoric Diester Hydrolases; Signal Transduction; Theophylline

1996
Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 2

    Topics: Adenosine Deaminase; Animals; Biological Transport; Caffeine; Cell Division; Cell Line; Glucose; Kidney; LLC-PK1 Cells; Phenylisopropyladenosine; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Swine; Theophylline; Up-Regulation

1996
Fever from caffeine.
    Allergy, 1996, Volume: 51, Issue:3

    Topics: Caffeine; Cross Reactions; Female; Fever; Humans; Middle Aged; Theophylline

1996
An adenosine agonist increases blood flow and density of capillary branches in the optic tectum of Xenopus laevis tadpoles.
    Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Capillaries; Microcirculation; Microscopy, Video; Neovascularization, Physiologic; Nitroglycerin; Regional Blood Flow; Superior Colliculi; Theophylline; Time Factors; Vasodilator Agents; Xenopus laevis

1994
Overcoming of P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cells could be induced by pentoxifyline but not by theophylline and caffeine.
    Neoplasma, 1996, Volume: 43, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium; Calcium Channels; Drug Interactions; Drug Resistance, Neoplasm; Leukemia L1210; Mice; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha; Vincristine

1996
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:9

    Topics: Age Factors; Alcohol Drinking; Aminobiphenyl Compounds; Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Coffee; Cytochrome P-450 CYP1A2; DNA Adducts; Drinking; Enzyme Induction; Glutathione Transferase; Hemoglobins; Humans; Male; Meat; Middle Aged; Nicotiana; Oxidation-Reduction; Phenotype; Plants, Toxic; Polymorphism, Genetic; Risk Factors; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms

1996
Microassay of amiodarone and desethylamiodarone in serum by capillary electrophoresis with head-column field-amplified sample stacking.
    Clinical chemistry, 1996, Volume: 42, Issue:11

    Topics: Amiodarone; Caffeine; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Microchemistry; Reproducibility of Results; Theophylline

1996
Theoretical relationship between the post-administration time and plasma or urinary concentration of a metabolite and the unchanged drug. Administration of caffeine to horses.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:10

    Topics: Animals; Caffeine; Horses; Substance Abuse Detection; Theophylline

1996
Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents.
    Neuroscience letters, 1996, Nov-08, Volume: 218, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Motor Neurons; Oxidopamine; Purinergic P1 Receptor Antagonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Sympatholytics; Theophylline

1996
Role of cyclic nucleotides in contraction induced by oxytocin in the testicular capsule of the rat in vitro.
    Pharmacology, 1996, Volume: 53, Issue:5

    Topics: Animals; Arginine; Caffeine; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Male; omega-N-Methylarginine; Oxytocin; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Testis; Theophylline

1996
Threshold level for theophylline in doping analysis.
    Journal of chromatography. B, Biomedical applications, 1996, Dec-06, Volume: 687, Issue:1

    Topics: Caffeine; Chromatography, High Pressure Liquid; Doping in Sports; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Theophylline

1996
Use of 3-(1,8-naphthalimido)propyl-modified silyl silica gel as a stationary phase for the high-performance liquid chromatographic separation of purine derivatives.
    Journal of chromatography. A, 1996, Jan-26, Volume: 722, Issue:1-2

    Topics: 1-Naphthylamine; Adult; Beverages; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male; Purines; Silica Gel; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tablets; Theophylline

1996
Effects of caffeine and theophylline on prostaglandin production by guinea-pig endometrium.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Caffeine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Endometrium; Female; Guinea Pigs; Prostaglandins; Ryanodine; Theophylline; Time Factors

1997
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2

    Topics: Animals; Caffeine; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Kidney; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Uric Acid

1997
Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2

    Topics: Animals; Beverages; Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Sodium Dodecyl Sulfate; Tablets; Theobromine; Theophylline; Uric Acid

1997
Theophylline has no advantages over caffeine as a putative model drug for assessing CYPIA2 activity in humans.
    British journal of clinical pharmacology, 1997, Volume: 43, Issue:3

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Male; Metabolic Clearance Rate; Methylation; Microsomes, Liver; Phosphodiesterase Inhibitors; Theophylline

1997
[Development of syringe-type off line pre-column and simultaneous quantitation of four xanthine derivatives (caffeine, theobromine, theophylline and paraxanthine) in serum].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1997, Volume: 117, Issue:3

    Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Theobromine; Theophylline; Xanthines

1997
Inhibitory effect of methylxanthines on glycine-induced Cl current in dissociated rat hippocampal neurons.
    Annals of the New York Academy of Sciences, 1993, Dec-20, Volume: 707

    Topics: Animals; Caffeine; Chloride Channels; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Pentoxifylline; Pyramidal Cells; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines

1993
Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.
    Pharmacogenetics, 1996, Volume: 6, Issue:2

    Topics: Aged; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Female; Genotype; Humans; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Saliva; Theophylline

1996
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jun-15, Volume: 17, Issue:12

    Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines

1997
Prostaglandin production by guinea-pig endometrial cells: effects of caffeine and other modulators of intracellular calcium.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:5

    Topics: Animals; Berberine; Caffeine; Calcium; Cell Separation; Cells, Cultured; Colforsin; Dinoprost; Drug Interactions; Endometrium; Female; Gallic Acid; Guinea Pigs; Ryanodine; Sulfonamides; Thapsigargin; Theophylline; Trifluoperazine

1997
Antinociceptive effect of purine nucleotides.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:10

    Topics: Analgesics; Animals; Caffeine; Male; Mice; Naloxone; Narcotic Antagonists; Nociceptors; Purine Nucleotides; Quinidine; Receptors, Purinergic P1; Receptors, Purinergic P2; Rosaniline Dyes; Suramin; Theophylline

1996
Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes.
    Biochemical and biophysical research communications, 1997, Jun-27, Volume: 235, Issue:3

    Topics: Animals; Biotransformation; Caffeine; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Proadifen; Rats; Rats, Sprague-Dawley; Species Specificity; Theobromine; Theophylline

1997
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines

1997
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA.
    Nature structural biology, 1997, Volume: 4, Issue:8

    Topics: Bronchodilator Agents; Caffeine; Cytosine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; RNA; Sensitivity and Specificity; Theophylline

1997
[Effects of beta-adrenergic agonists and phosphodiesterase inhibitors on the outflow facility of the eye].
    Nippon Ganka Gakkai zasshi, 1997, Volume: 101, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Caffeine; Cattle; Cells, Cultured; Dobutamine; Epinephrine; Isoproterenol; Phosphodiesterase Inhibitors; Theophylline; Trabecular Meshwork

1997
Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys.
    American journal of veterinary research, 1997, Volume: 58, Issue:8

    Topics: Animals; Caffeine; Equidae; Female; Horses; Male; Metabolic Clearance Rate; Species Specificity; Theobromine; Theophylline; Time Factors

1997
Comparison by external quality assessment of performance of analytical systems for measurement of therapeutic drugs in serum.
    Therapeutic drug monitoring, 1997, Volume: 19, Issue:4

    Topics: Anti-Arrhythmia Agents; Anticonvulsants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography; Digoxin; Drug Monitoring; Immunoenzyme Techniques; Laboratories; Quality Control; Radioimmunoassay; Surveys and Questionnaires; Theophylline

1997
Effects of chronic caffeine administration on respiration and schedule-controlled behavior in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Female; Macaca mulatta; Male; Pyrrolidinones; Respiration; Rolipram; Theophylline

1997
Protective effect of three xanthine derivatives (theophylline, caffeine and pentoxifylline) against the cyclosporin A-induced glomerular contraction in isolated glomeruli and cultured mesangial cells.
    Nephron, 1997, Volume: 77, Issue:4

    Topics: Animals; Caffeine; Cells, Cultured; Cyclosporine; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Immunosuppressive Agents; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Pentoxifylline; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines

1997
Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 40, Issue:2

    Topics: Acetaminophen; Animals; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Female; Gene Expression Regulation, Enzymologic; Immunoblotting; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oligonucleotide Probes; Phenotype; RNA, Messenger; Sex Factors; Theophylline

1997
Interaction of oral anticoagulants with methyl xanthines.
    Die Pharmazie, 1997, Volume: 52, Issue:12

    Topics: Animals; Anticoagulants; Biological Availability; Caffeine; Central Nervous System Stimulants; Dicumarol; Drug Interactions; Male; Rabbits; Spectrophotometry, Ultraviolet; Theophylline; Thermodynamics; Warfarin; Xanthines

1997
Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy.
    Annals of epidemiology, 1998, Volume: 8, Issue:2

    Topics: Biomarkers; Blood Specimen Collection; Caffeine; Cohort Studies; Diet; Female; Humans; Mental Recall; Pregnancy; Reproducibility of Results; Theophylline

1998
Functional coupling of secretion and capacitative calcium entry in PC12 cells.
    Biochemical and biophysical research communications, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Dopamine; Exocytosis; Extracellular Space; Indoles; Intracellular Fluid; PC12 Cells; Rats; Signal Transduction; Theophylline; Zinc

1998
Studies on diffusion in alginate gels. II. Effect of acid and subsequent re-exposure to calcium on the diffusion of caffeine and theophylline in alginate gel films.
    Pharmaceutical development and technology, 1997, Volume: 2, Issue:3

    Topics: Administration, Oral; Alginates; Biocompatible Materials; Caffeine; Calcium; Diffusion; Gastric Acid; Gels; Glucuronic Acid; Hexuronic Acids; Pepsin A; Permeability; Solubility; Theophylline; Water

1997
Evaluation of the toxicity of guarana with in vitro bioassays.
    Ecotoxicology and environmental safety, 1998, Volume: 39, Issue:3

    Topics: Animals; Caffeine; Cell Division; CHO Cells; Cricetinae; Drug Combinations; Indicators and Reagents; Neutral Red; Organic Chemicals; Photobacterium; Plant Extracts; Proteins; Seeds; Tetrazolium Salts; Theobromine; Theophylline

1998
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
    Melanoma research, 1998, Volume: 8, Issue:2

    Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Neoplasm Invasiveness; Theobromine; Theophylline; Transglutaminases; Tumor Cells, Cultured

1998
Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Apr-10, Volume: 707, Issue:1-2

    Topics: Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Perchlorates; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Theophylline

1998
Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum.
    Planta medica, 1998, Volume: 64, Issue:4

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Lipolysis; Male; Medicine, Chinese Traditional; Plant Stems; Plants, Medicinal; Rats; Rats, Wistar; Theophylline

1998
Effects of caffeine on lipoprotein lipase gene expression during the adipocyte differentiation process.
    Lipids, 1998, Volume: 33, Issue:5

    Topics: 3T3 Cells; Adipocytes; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Gene Expression Regulation, Enzymologic; Kinetics; Lipoprotein Lipase; Mice; RNA, Messenger; Theophylline; Time Factors; Triglycerides

1998
Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:6

    Topics: Animals; Blood Glucose; Caffeine; Drug Combinations; Epinephrine; Fasting; Glycogen; Male; Maltose; Mice; Physical Conditioning, Animal; Seeds; Theobromine; Theophylline

1998
Functional coupling of secretion and capacitative calcium entry in PC12 cells.
    Biochemical and biophysical research communications, 1998, Jun-18, Volume: 247, Issue:2

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Dopamine; Exocytosis; Extracellular Space; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Ion Transport; PC12 Cells; Rats; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Thapsigargin; Theophylline

1998
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles

1998
[Effect of caffeine and theophylline on Ca2+ sensitivity of troponin and Ca2+ release from SR in saponin-skinned rat cardiac muscle].
    Sheng li xue bao : [Acta physiologica Sinica], 1997, Volume: 49, Issue:3

    Topics: Animals; Caffeine; Calcium; Cardiovascular Agents; Myocardium; Rats; Saponins; Sarcoplasmic Reticulum; Stimulation, Chemical; Theophylline; Troponin

1997
Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons.
    Amino acids, 1998, Volume: 14, Issue:1-3

    Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Neostriatum; Neurons; Patch-Clamp Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Signal Transduction; Theophylline

1998
Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system.
    Magnesium research, 1998, Volume: 11, Issue:4

    Topics: Adenosine; Animals; Biogenic Monoamines; Caffeine; Carbamazepine; Central Nervous System; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Magnesium; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Theobromine; Theophylline; Visual Cortex

1998
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
    Annals of tropical paediatrics, 1998, Volume: 18, Issue:3

    Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn; Infant, Small for Gestational Age; Male; Oxygen; Theophylline

1998
Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin.
    The European journal of neuroscience, 1999, Volume: 11, Issue:1

    Topics: Adenosine; Animals; Antihypertensive Agents; Biological Transport; Caffeine; Central Nervous System Stimulants; Fluoxetine; Hippocampus; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quipazine; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Theobromine; Theophylline; Vasodilator Agents

1999
Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat.
    Toxicology letters, 1999, Jan-11, Volume: 104, Issue:1-2

    Topics: Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dealkylation; Dinitrobenzenes; Male; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines

1999
The effect of the aqueous solubility of xanthine derivatives on the release mechanism from ethylcellulose matrix tablets.
    International journal of pharmaceutics, 1999, Mar-01, Volume: 179, Issue:1

    Topics: Algorithms; Caffeine; Cellulose; Dyphylline; Kinetics; Solubility; Spectrophotometry, Ultraviolet; Tablets; Theophylline; Xanthines

1999
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines

1999
Direct injection determination of theophylline and caffeine in blood serum by high-performance liquid chromatography using an ODS column coated with a zwitterionic bile acid derivative.
    The Analyst, 1998, Volume: 123, Issue:8

    Topics: Bronchodilator Agents; Caffeine; Cholic Acids; Chromatography, High Pressure Liquid; Humans; Phosphodiesterase Inhibitors; Theophylline

1998
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines

1999
Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism.
    Journal of molecular recognition : JMR, 1998,Winter, Volume: 11, Issue:1-6

    Topics: Caffeine; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Delivery Systems; Humans; In Vitro Techniques; Kinetics; Molecular Mimicry; Polymers; Spectrophotometry, Ultraviolet; Theophylline

1998
Development and clinical application of high performance liquid chromatography for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine.
    Biomedical chromatography : BMC, 1999, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Aged; Asthma; Caffeine; Child; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Humans; Male; Middle Aged; Theophylline

1999
Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration.
    Neuroscience, 1999, Volume: 89, Issue:3

    Topics: Adenosine; Animals; Antipsychotic Agents; Behavior, Animal; Caffeine; Catalepsy; Clozapine; Corpus Striatum; Cyclic AMP; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, fos; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Second Messenger Systems; Serotonin; Serotonin Antagonists; Theophylline

1999
Possible novel mechanism for bitter taste mediated through cGMP.
    Journal of neurophysiology, 1999, Volume: 81, Issue:4

    Topics: Aminoquinolines; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Glycine Agents; Methylene Blue; Mice; Nitro Compounds; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; Signal Transduction; Strychnine; Sulfhydryl Reagents; Taste; Theophylline

1999
Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
    Pharmacogenetics, 1999, Volume: 9, Issue:2

    Topics: Adult; Anthropometry; Caffeine; Coffee; Contraceptives, Oral; Cytochrome P-450 CYP1A2; Female; Humans; Male; Reference Values; Saliva; Smoking; Theophylline; White People

1999
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: Animals; Behavior, Animal; Caffeine; Cocaine; Extinction, Psychological; Male; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Reward; Substance Abuse, Intravenous; Theophylline; Triazoles; Xanthines

1999
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
    Biomedical chromatography : BMC, 1999, Volume: 13, Issue:4

    Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline

1999
Chronic effects of xanthines on levels of central receptors in mice.
    Cellular and molecular neurobiology, 1999, Volume: 19, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines

1999
Stable isotopes labeling of drugs in pediatric clinical pharmacology.
    Pediatrics, 1999, Volume: 104, Issue:3 Pt 2

    Topics: Adolescent; Breath Tests; Caffeine; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Therapy; Helicobacter Infections; Helicobacter pylori; Human Growth Hormone; Humans; Infant; Infant, Newborn; Isotope Labeling; Pancreas; Pediatrics; Theophylline

1999
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium.
    Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2

    Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase

1999
Separation of theophylline, caffeine and related drugs by normal-phase capillary electrochromatography.
    Electrophoresis, 1999, Volume: 20, Issue:12

    Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Electric Conductivity; Electrophoresis, Capillary; Hydrochlorothiazide; Molecular Structure; Niacin; Phenylbutazone; Theobromine; Theophylline

1999
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines

1999
Do ryanodine receptors regulate transmitter release at the neuromuscular junction of rat?
    Neuroscience letters, 1999, Oct-29, Volume: 274, Issue:3

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Central Nervous System Stimulants; Gallic Acid; Membrane Potentials; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Theophylline; Xanthines

1999
Extraction of purine alkaloids from maté (Ilex paraguariensis) using supercritical CO(2).
    Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:9

    Topics: Beverages; Caffeine; Carbon Dioxide; Chromatography, High Pressure Liquid; Magnoliopsida; Pressure; Solubility; Theobromine; Theophylline

1999
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:23

    Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Glucuronidase; Humans; Indicators and Reagents; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Theophylline

1999
Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:12

    Topics: Animals; Breeding; Caffeine; Chromosome Mapping; Cytochrome P-450 CYP1A2; Female; Genetic Markers; Genotype; Male; Mice; Mice, Inbred C3H; Multifactorial Inheritance; Phenotype; Quantitative Trait, Heritable; Sex Factors; Theophylline

1999
Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion.
    The New England journal of medicine, 1999, Nov-25, Volume: 341, Issue:22

    Topics: Abortion, Spontaneous; Adult; Caffeine; Case-Control Studies; Female; Humans; Odds Ratio; Pregnancy; Retrospective Studies; Risk Factors; Theophylline

1999
Caffeine--filtering the facts.
    The New England journal of medicine, 1999, Nov-25, Volume: 341, Issue:22

    Topics: Abortion, Spontaneous; Breast Feeding; Caffeine; Child Development; Female; Fetus; Humans; Infant; Pregnancy; Theophylline

1999
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
    Psychopharmacology, 1999, Volume: 147, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Caffeine; Catalepsy; Dopamine Agents; Hypokinesia; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Reserpine; Theophylline

1999
The confirmation and control of metabolic caffeine in standardbred horses after administration of theophylline.
    Journal of veterinary pharmacology and therapeutics, 1999, Volume: 22, Issue:5

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Doping in Sports; Female; Horses; Theophylline; Vasodilator Agents

1999
Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method.
    Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:4

    Topics: Acetaminophen; Caffeine; Chlorzoxazone; Chromatography, Thin Layer; Densitometry; Diflunisal; Dosage Forms; Naproxen; Pharmaceutical Preparations; Solvents; Theophylline

1999
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.
    Life sciences, 2000, Volume: 66, Issue:10

    Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Theobromine; Theophylline

2000
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography. Stress test for stability evaluation.
    Journal of chromatography. A, 2000, Feb-18, Volume: 870, Issue:1-2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Stability; Evaluation Studies as Topic; Reproducibility of Results; Theophylline

2000
Effects of caffeine and theophylline on the development of dental caries in rats.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:3

    Topics: Animals; Caffeine; Dental Caries; Female; Male; Rats; Rats, Wistar; Saliva; Stomach Ulcer; Streptococcal Infections; Streptococcus sobrinus; Theophylline

2000
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant
    Arthritis and rheumatism, 2000, Volume: 43, Issue:3

    Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Experimental; Arthrography; Caffeine; Female; Methotrexate; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Lew; Theophylline

2000
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:2

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Intestine, Small; Ketoconazole; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Theobromine; Theophylline

2000
Caffeine consumption and the risk of spontaneous abortions.
    The Journal of family practice, 2000, Volume: 49, Issue:3

    Topics: Abortion, Spontaneous; Caffeine; Case-Control Studies; Female; Humans; Pregnancy; Reproducibility of Results; Retrospective Studies; Risk Factors; Smoking; Theophylline

2000
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
    Journal of neurophysiology, 2000, Volume: 83, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines

2000
Molecular interactions and metal binding in the theophylline-binding core of an RNA aptamer.
    RNA (New York, N.Y.), 2000, Volume: 6, Issue:5

    Topics: Base Sequence; Binding Sites; Bronchodilator Agents; Caffeine; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Metals; Models, Molecular; Mutation; Nucleic Acid Conformation; Polyribonucleotides; RNA; Theophylline

2000
Pharmacokinetics of theophylline and caffeine after intravenous administration of aminophylline to premature neonates in Korea.
    Research communications in molecular pathology and pharmacology, 1999, Volume: 105, Issue:1-2

    Topics: Aminophylline; Apnea; Caffeine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Korea; Male; Theophylline

1999
Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Caffeine; Corpus Striatum; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Drinking; Eating; Male; Neural Pathways; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sulpiride; Syndrome; Theophylline; Xanthines

2000
The pharmacokinetics, metabolism and urinary detection time of caffeine in camels.
    Research in veterinary science, 2000, Volume: 69, Issue:1

    Topics: Animals; Area Under Curve; Caffeine; Camelus; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Injections, Intravenous; Male; Protein Binding; Regression Analysis; Statistics, Nonparametric; Theobromine; Theophylline

2000
Myoglobinuria after ingestion of extracts of guarana, Ginkgo biloba and kava.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2000, Volume: 21, Issue:2

    Topics: Adult; Caffeine; Drug Combinations; Ginkgo biloba; Humans; Kava; Male; Myoglobinuria; Plant Extracts; Plants, Medicinal; Theobromine; Theophylline

2000
Parkinson's disease and CYP1A2 activity.
    British journal of clinical pharmacology, 2000, Volume: 50, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Saliva; Theophylline

2000
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines

2000
In vivo modulation of CYP enzymes by quinidine and rifampin.
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4

    Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline

2000
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines

2000
Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:6

    Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Hindlimb; In Vitro Techniques; Intracellular Membranes; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Osmolar Concentration; Procaine; Theobromine; Theophylline

2000
Characterisation of ATP-induced facilitation of transmission in rat hippocampus.
    European journal of pharmacology, 2000, Dec-08, Volume: 409, Issue:2

    Topics: Adenosine Deaminase; Adenosine Triphosphate; Animals; Caffeine; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Synaptic Transmission; Theophylline

2000
On mathematical models of microdialysis: geometry, steady-state models, recovery and probe radius.
    Advanced drug delivery reviews, 2000, Dec-15, Volume: 45, Issue:2-3

    Topics: Animals; Caffeine; Corpus Striatum; Dopamine; Male; Mathematics; Microdialysis; Models, Theoretical; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Theophylline

2000
Parkinson's disease and impaired chemosensitivity to hypoxia.
    Lancet (London, England), 2000, Dec-16, Volume: 356, Issue:9247

    Topics: Caffeine; Humans; Parkinson Disease; Phosphodiesterase Inhibitors; Respiration; Theophylline

2000
Calculation of the dimensions of dosage forms with release controlled by diffusion for in vivo use.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2001, Volume: 51, Issue:1

    Topics: Administration, Oral; Caffeine; Central Nervous System Stimulants; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diffusion; Drug Administration Schedule; Drug Carriers; Humans; Models, Chemical; Theophylline; Tissue Distribution; Vasodilator Agents

2001
Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats.
    European journal of pharmacology, 2001, Feb-02, Volume: 412, Issue:3

    Topics: Adenosine; Analgesics, Opioid; Animals; Caffeine; Electrophysiology; Male; Medulla Oblongata; Microinjections; Morphine; Morphine Dependence; Neurons; Purinergic P1 Receptor Agonists; Rats; Substance Withdrawal Syndrome; Theophylline

2001
Adenosine induces initial hypoxic-ischemic depression of synaptic transmission in the rat hippocampus in vivo.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3

    Topics: Acid-Base Equilibrium; Adenosine; Animals; Blood Pressure; Caffeine; Carotid Artery, Common; Constriction; Excitatory Postsynaptic Potentials; Heart Rate; Hippocampus; Hypoxia-Ischemia, Brain; Male; Oxygen; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline

2001
Suspected caffeine and ephedrine toxicosis resulting from ingestion of an herbal supplement containing guarana and ma huang in dogs: 47 cases (1997-1999).
    Journal of the American Veterinary Medical Association, 2001, Jan-15, Volume: 218, Issue:2

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Dietary Supplements; Dog Diseases; Dogs; Drug Combinations; Ephedrine; Female; Male; Phytotherapy; Retrospective Studies; Theobromine; Theophylline

2001
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
    Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:2

    Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chromatography, Gas; Cytosol; Diet; Enzyme Inhibitors; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometry; Hypoxanthine; Male; Meat; NAD; Neoplasms; Niacinamide; Phosphodiesterase Inhibitors; Prostate; Prostatic Neoplasms; Purines; Rats; Rats, Sprague-Dawley; Spin Trapping; Temperature; Theobromine; Theophylline; Time Factors; Vasodilator Agents; Xanthine; Xanthine Oxidase

2001
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.
    Biochemical pharmacology, 2001, Feb-15, Volume: 61, Issue:4

    Topics: Adenosine; Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline; Transfection

2001
[Cerebral infarction in a patient consuming MaHuang extract and guarana].
    Presse medicale (Paris, France : 1983), 2001, Feb-03, Volume: 30, Issue:4

    Topics: Adult; Caffeine; Cerebral Angiography; Cerebral Infarction; Drug Combinations; Ephedrine; Female; Humans; Theobromine; Theophylline

2001
[Use of the paraxanthine/caffeine ratio in the saliva of patients with liver cirrhosis].
    Casopis lekaru ceskych, 2001, Feb-01, Volume: 140, Issue:2

    Topics: Caffeine; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Saliva; Theophylline

2001
Seizure activity and unresponsiveness after hydroxycut ingestion.
    Pharmacotherapy, 2001, Volume: 21, Issue:5

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herbal; Ephedra sinica; Ephedrine; Humans; Male; Phytotherapy; Picolinic Acids; Plant Preparations; Polysaccharides; Seizures; Theobromine; Theophylline

2001
[Separation of alkaloids in tea by high-speed counter-current chromatography].
    Se pu = Chinese journal of chromatography, 1998, Volume: 16, Issue:4

    Topics: Alkaloids; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Tea; Theophylline

1998
Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.
    The Medical journal of Australia, 2001, May-21, Volume: 174, Issue:10

    Topics: Adult; Beverages; Caffeine; Drug Combinations; Fatal Outcome; Female; Food, Organic; Humans; Mitral Valve Prolapse; Theobromine; Theophylline; Ventricular Fibrillation

2001
In vivo inhibition of human CYP1A2 activity by oltipraz.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:6

    Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes

2001
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
    Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:3

    Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines

2001
Glucose transporter type 1 deficiency syndrome (Glut1DS): methylxanthines potentiate GLUT1 haploinsufficiency in vitro.
    Pediatric research, 2001, Volume: 50, Issue:2

    Topics: 3-O-Methylglucose; Adolescent; Caffeine; Case-Control Studies; Child; Erythrocytes; Female; Humans; In Vitro Techniques; Kinetics; Male; Monosaccharide Transport Proteins; Mutation; Phenobarbital; Syndrome; Theophylline

2001
Detection of small organic analytes by fluorescing molecular switches.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:10

    Topics: Allosteric Site; Base Sequence; Binding Sites; Bronchodilator Agents; Caffeine; Dose-Response Relationship, Drug; Indicators and Reagents; Models, Biological; Molecular Sequence Data; Nucleic Acid Conformation; Protein Conformation; RNA; RNA, Catalytic; Sequence Analysis; Spectrometry, Fluorescence; Structure-Activity Relationship; Theophylline; Time Factors

2001
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines

2001
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines

1997
[HPLC determination of five caffeine metabolites].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines

1997
Venom from the ectoparasitic wasp Nasonia vitripennis increases Na+ influx and activates phospholipase C and phospholipase A2 dependent signal transduction pathways in cultured insect cells.
    Toxicon : official journal of the International Society on Toxinology, 2002, Volume: 40, Issue:1

    Topics: Animals; Caffeine; Calcium; Cell Death; Cell Membrane Permeability; Cells, Cultured; Cytosol; Enzyme Inhibitors; Estrenes; Female; Intercellular Signaling Peptides and Proteins; Neomycin; Peptide Fragments; Peptides; Phospholipases A; Phospholipases A2; Pyrrolidinones; Signal Transduction; Sodium; Theophylline; Type C Phospholipases; Uteroglobin; Wasp Venoms; Wasps

2002
Nanoparticles in plant extracts--factors which influence the formation of nanoparticles in black tea infusions.
    Die Pharmazie, 2001, Volume: 56, Issue:10

    Topics: Absorptiometry, Photon; Caffeine; Microspheres; Models, Molecular; Particle Size; Plant Extracts; Tea; Theobromine; Theophylline

2001
Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.
    Diabetes, 2001, Volume: 50, Issue:12

    Topics: Adult; Albumins; Blood Flow Velocity; Blood Glucose; Blood Volume; Brachial Artery; Caffeine; Capillaries; Female; Glucose; Humans; Insulin; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Theophylline; Xanthines

2001
Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:5

    Topics: Adult; Age Factors; Aged; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Theophylline; Time Factors

2001
Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography.
    Journal of chromatography. A, 2001, Dec-07, Volume: 937, Issue:1-2

    Topics: Caffeine; Chromatography, Liquid; Food Analysis; Food Preservatives; Pharmaceutical Preparations; Spectrophotometry, Ultraviolet; Sweetening Agents; Theobromine; Theophylline

2001
Maternal serum caffeine metabolites and small-for-gestational age birth.
    American journal of epidemiology, 2002, Jan-01, Volume: 155, Issue:1

    Topics: Adult; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Risk Factors; Smoking; Theophylline

2002
Effects of caffeine and its reactive metabolites theophylline and theobromine on the differentiating testis.
    Reproduction, fertility, and development, 2001, Volume: 13, Issue:5-6

    Topics: Animals; Caffeine; Cell Differentiation; Female; Gestational Age; Leydig Cells; Male; Maternal-Fetal Exchange; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Seminiferous Tubules; Testis; Theobromine; Theophylline

2001
Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
    Planta medica, 2002, Volume: 68, Issue:1

    Topics: 3T3 Cells; Adipocytes; Animals; Biflavonoids; Caffeine; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Ginkgo biloba; Lipolysis; Medicine, Chinese Traditional; Mice; Molecular Structure; Plant Extracts; Theophylline

2002
Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography.
    Journal of chromatographic science, 2002, Volume: 40, Issue:1

    Topics: Beverages; Caffeine; Calibration; Chromatography, High Pressure Liquid; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

2002
Study of catechin and xanthine tea profiles as geographical tracers.
    Journal of agricultural and food chemistry, 2002, Mar-27, Volume: 50, Issue:7

    Topics: Caffeine; Catechin; China; Chromatography, High Pressure Liquid; Gallic Acid; India; Japan; Kenya; Sri Lanka; Tea; Theobromine; Theophylline; Xanthines

2002
Continuous measurement of caffeine and two metabolites in blood and skeletal muscle of unrestrained adult horses by semi-automated in vivo microdialysis.
    Journal of veterinary pharmacology and therapeutics, 2001, Volume: 24, Issue:6

    Topics: Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Horses; Injections, Intravenous; Microdialysis; Muscle, Skeletal; Reproducibility of Results; Theobromine; Theophylline

2001
Dopaminergic mechanism for caffeine-produced cocaine seeking in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Caffeine; Central Nervous System Stimulants; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Salicylamides; Self Administration; Theophylline; Vasodilator Agents

2002
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:4

    Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Colorectal Neoplasms; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Theophylline; Uric Acid

2002
Reverse iontophoretic monitoring in premature neonates: feasibility and potential.
    Journal of controlled release : official journal of the Controlled Release Society, 2002, May-17, Volume: 81, Issue:1-2

    Topics: Animals; Caffeine; Drug Monitoring; Ear; Electrodes; Feasibility Studies; Humans; Infant, Newborn; Infant, Premature; Iontophoresis; Models, Animal; Skin; Swine; Theophylline

2002
[Application of statistical simulation spectrophotometry to the determination of four medicaments in feibaosanxiao tablets].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:9

    Topics: Acetaminophen; Caffeine; Drug Combinations; Monte Carlo Method; Phenytoin; Spectrophotometry; Tablets; Theophylline

1998
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney.
    European journal of pharmacology, 2002, May-10, Volume: 442, Issue:3

    Topics: Aminophylline; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Caffeine; Catalase; Cisplatin; Glutathione Peroxidase; Kidney; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Superoxide Dismutase; Theophylline; Xanthines

2002
Water dynamics in channel hydrates investigated using H/D exchange.
    International journal of pharmaceutics, 2002, Jul-25, Volume: 241, Issue:2

    Topics: Caffeine; Chemistry, Pharmaceutical; Cromolyn Sodium; Deuterium Oxide; Spectrum Analysis, Raman; Theophylline; Water

2002
Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.
    Biochemical pharmacology, 2002, Jun-15, Volume: 63, Issue:12

    Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Humans; Mice; Phosphodiesterase Inhibitors; Species Specificity; Theophylline

2002
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
    The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Deoxyglucose; Dimerization; Flavins; Glucose; Kinetics; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Recombinant Fusion Proteins; Theophylline; Transfection; Triazoles

2002
Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-01, Volume: 22, Issue:15

    Topics: Animals; Behavior, Animal; Caffeine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Injections, Intraperitoneal; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Theophylline; Triazoles; Wakefulness

2002
Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats.
    Journal of neurochemistry, 2002, Volume: 82, Issue:3

    Topics: Animals; Binding, Competitive; Brain; Caffeine; Down-Regulation; Female; Gestational Age; Pregnancy; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Xanthines

2002
Electronic structure of some adenosine receptor antagonists. III. Quantitative investigation of the electronic absorption spectra of alkyl xanthines.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2002, Volume: 58, Issue:9

    Topics: Caffeine; Purinergic P1 Receptor Antagonists; Spectrum Analysis; Theobromine; Theophylline

2002
Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.
    Psychopharmacology, 2002, Volume: 162, Issue:4

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Differential Threshold; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Ganglionic Stimulants; Generalization, Stimulus; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Theobromine; Theophylline; Vasodilator Agents

2002
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
    Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2

    Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines

2002
A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.
    RNA (New York, N.Y.), 2002, Volume: 8, Issue:10

    Topics: Base Pairing; Base Sequence; Binding Sites; Biosensing Techniques; Caffeine; Fluorescence Resonance Energy Transfer; Ligands; Molecular Sequence Data; Nucleic Acid Conformation; RNA; RNA, Catalytic; Sensitivity and Specificity; Theophylline

2002
[Research on the separation of caffeine and its nine analogues by micellar electrokinetic capillary chromatography].
    Se pu = Chinese journal of chromatography, 2002, Volume: 20, Issue:3

    Topics: Buffers; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Hydrogen-Ion Concentration; Theophylline; Xanthines

2002
[Direct determination of purine bases in tea by reversed-phase high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 1999, Volume: 17, Issue:5

    Topics: Caffeine; Chromatography, High Pressure Liquid; Tea; Theobromine; Theophylline

1999
Caffeine enhances myocardial uptake of idarubicin but reverses its negative inotropic effect.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Caffeine; Drug Interactions; Heart Rate; Idarubicin; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Theophylline; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure

2003
Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.
    American journal of veterinary research, 2003, Volume: 64, Issue:2

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Horses; Male; Neostriatum; Prosencephalon; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theobromine; Theophylline

2003
Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.
    Toxicology, 2003, Apr-15, Volume: 186, Issue:1-2

    Topics: Animals; Biotransformation; Caffeine; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ellagic Acid; Enzyme Induction; Glutathione Transferase; Hydrolyzable Tannins; Hydroxybenzoates; Kidney; Liver; Male; Oxidoreductases; Rats; Rats, Wistar; Theobromine; Theophylline; Toluidines

2003
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
    Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline

2003
De-intercalation of ethidium bromide and acridine orange by xanthine derivatives and their modulatory effect on anticancer agents: a study of DNA-directed toxicity enlightened by time correlated single photon counting.
    Journal of biomolecular structure & dynamics, 2003, Volume: 20, Issue:5

    Topics: Acridine Orange; Antineoplastic Agents; Caffeine; DNA; Ethidium; Fluorescent Dyes; Humans; Intercalating Agents; Models, Biological; Photons; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines

2003
RNA binding efficacy of theophylline, theobromine and caffeine.
    Journal of biomolecular structure & dynamics, 2003, Volume: 20, Issue:5

    Topics: Animals; Caffeine; RNA, Fungal; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline

2003
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines

2003
Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.
    British journal of pharmacology, 2003, Volume: 138, Issue:7

    Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caffeine; Cells, Cultured; Central Nervous System Diseases; Cerebellum; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Triazines; Triazoles

2003
Study on the paper substrate room temperature phosphorescence of theobromine, caffeine and theophylline and analytical application.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2003, Volume: 59, Issue:7

    Topics: Aminophylline; Cacao; Caffeine; Coffee; Hydrogen-Ion Concentration; Luminescence; Metals, Heavy; Paper; Spectrometry, Fluorescence; Tea; Temperature; Theobromine; Theophylline

2003
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:6

    Topics: Animals; Blotting, Western; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Dietary Supplements; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Male; Microsomes, Liver; Obesity; Plant Extracts; Rats; Rats, Sprague-Dawley; Smoking; Theophylline

2003
Selective solid-phase extraction sorbent for caffeine made by molecular imprinting.
    Journal of chromatography. A, 2002, Mar-01, Volume: 948, Issue:1-2

    Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Humans; Hydrogen-Ion Concentration; Polymers; Theobromine; Theophylline

2002
Acute caffeine treatment increases extracellular nucleotide hydrolysis from rat striatal and hippocampal synaptosomes.
    Neurochemical research, 2003, Volume: 28, Issue:8

    Topics: Adenine Nucleotides; Animals; Caffeine; Extracellular Space; Hippocampus; Male; Rats; Rats, Wistar; Synaptosomes; Theophylline

2003
Simultaneous determination of theophylline and caffeine by proton magnetic resonance spectroscopy using partial least squares regression techniques.
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2003, Volume: 19, Issue:7

    Topics: Caffeine; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Tablets; Theophylline

2003
Repeatability and reproducibility of high concentration data in reversed-phase liquid chromatography. I. Overloaded band profiles on Kromasil-C18.
    Journal of chromatography. A, 2003, Jun-27, Volume: 1003, Issue:1-2

    Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Indicators and Reagents; Mathematics; Phenol; Propranolol; Reproducibility of Results; Theophylline

2003
Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2003, Volume: 86 Suppl 2

    Topics: Adult; Caffeine; Carbon Dioxide; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Middle Aged; Polycyclic Aromatic Hydrocarbons; Theophylline; Vehicle Emissions

2003
Interaction of metal ions with caffeine and theophylline: stability and structural features.
    Journal of biomolecular structure & dynamics, 2003, Volume: 21, Issue:2

    Topics: Caffeine; Ions; Metals; Molecular Structure; Solutions; Spectroscopy, Fourier Transform Infrared; Theophylline

2003
The effect of theophylline with ethylenediamine (aminophylline) and caffeine on cerebral hemodynamics and cerebrospinal fluid pressure in patients with hypertensive headaches.
    The American journal of the medical sciences, 1952, Volume: 224, Issue:4

    Topics: Aminophylline; Caffeine; Cerebrospinal Fluid Pressure; Ethylenediamines; Headache; Hemodynamics; Humans; Hypertension; Theophylline

1952
The action of solubilizing agents on the solubility of xanthine derivatives in water. I. The application of partition studies to theophylline and caffeine combinations.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952, Volume: 41, Issue:10

    Topics: Caffeine; Diuretics; Solubility; Theophylline; Water; Xanthines

1952
The action of solubilizing agents on the solubility of xanthine derivatives in water. II. The application of conductimetric titrations to the study of xanthine combinations.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952, Volume: 41, Issue:10

    Topics: Caffeine; Diuretics; Solubility; Theobromine; Theophylline; Water; Xanthine; Xanthines

1952
The action of solubilizing agents on the solubility of xanthine derivatives in water. III. The application of cryoscopy to the study of caffeine, theophylline, and theobromine with solubilizing agents.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952, Volume: 41, Issue:10

    Topics: Caffeine; Diuretics; Solubility; Theobromine; Theophylline; Water; Xanthines

1952
The metabolism of caffeine and theophylline.
    The Journal of biological chemistry, 1953, Volume: 200, Issue:1

    Topics: Body Fluids; Caffeine; Humans; Theophylline; Uric Acid; Urine

1953
Growth promotion in carnivorous protozoa by substituted purines.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 83, Issue:3

    Topics: Animals; Caffeine; Eukaryota; Guanine; Humans; Invertebrates; Purines; Theobromine; Theophylline

1953
Toxicity of caffeine, theobromine and theophylline.
    Acta pharmacologica et toxicologica, 1953, Volume: 9, Issue:3

    Topics: Caffeine; Diuretics; Humans; Theobromine; Theophylline

1953
Study of possible complex formation between macromolecules and certain pharmaceuticals. I. Polyvinylpyrrolidone with sulfathiazole, procaine hydrochloride, sodium salicylate, benzyl penicillin, chloramphenicol, mandelic acid, caffeine, theophylline, and c
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1954, Volume: 43, Issue:7

    Topics: Caffeine; Chloramphenicol; Cortisone; Mandelic Acids; Penicillin G; Povidone; Procaine; Sodium Salicylate; Sulfathiazole; Sulfathiazoles; Theophylline

1954
[The effects of pervitin, arterenol, caffeine, euphyllin, cordalin and strophanthin on renal function].
    Zeitschrift fur klinische Medizin, 1954, Volume: 151, Issue:4

    Topics: Aminophylline; Amphetamine; Amphetamines; Caffeine; Kidney Function Tests; Norepinephrine; Strophanthins; Theophylline; Urinary Tract Physiological Phenomena

1954
Investigation of complexes formed in solution by caffeine. VI. Comparison of complexing behaviors of methylated xanthines with p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, and p-hydroxybenzoic acid.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1954, Volume: 43, Issue:9

    Topics: 4-Aminobenzoic Acid; Aspirin; Benzoates; Caffeine; Hydroxybenzoates; Pharmaceutical Solutions; Salicylic Acid; Solutions; Theobromine; Theophylline; Xanthines

1954
Action of purine alkaloids and caffeine drugs on hyaluronidase.
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1954, Volume: 148, Issue:11-12

    Topics: Caffeine; Coffee; Hyaluronoglucosaminidase; Plants; Tea; Theobromine; Theophylline

1954
[Studies on coronary-dilatating effects on Langendorff's preparation and its interpretation on the basis of competitive antagonism].
    Helvetica physiologica et pharmacologica acta, 1954, Volume: 12, Issue:3

    Topics: Caffeine; Cardiomegaly; Heart; Humans; Khellin; Papaverine; Theophylline

1954
[The effects of caffeine and theophylline on the myocardium].
    Archiv fur Kreislaufforschung, 1955, Volume: 23, Issue:1-3

    Topics: Caffeine; Heart; Humans; Myocardium; Theophylline

1955
[Effect of theophylline, caffeine and theobromine on contraction force, excitability refractory period and spontaneous frequency in isolated cat myocardium].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1956, Volume: 229, Issue:4

    Topics: Animals; Caffeine; Cats; Felis; Heart; Myocardium; Theobromine; Theophylline

1956
[Contractile action of methylxanthines].
    Archivio italiano di scienze farmacologiche, 1957, Volume: 7, Issue:3

    Topics: Caffeine; Humans; Muscle Contraction; Theobromine; Theophylline; Xanthines

1957
A study of the metabolism of theobromine, theophylline, and caffeine in man.
    The Journal of biological chemistry, 1957, Volume: 228, Issue:1

    Topics: Body Fluids; Caffeine; Humans; Male; Theobromine; Theophylline

1957
Complexes formed in solution by homologs of caffeine; interactions between p-hydroxybenzoic acid and ethyl, propyl, and butyl derivatives of theobromine, and theophylline.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1957, Volume: 46, Issue:1

    Topics: Caffeine; Hydroxybenzoates; Pharmaceutical Solutions; Solutions; Theobromine; Theophylline

1957
[Experiences with the antiemetic rodavan in prevention and therapy of postanesthesia vomiting].
    Zentralblatt fur Chirurgie, 1958, Aug-09, Volume: 83, Issue:32

    Topics: Antiemetics; Biomedical Research; Caffeine; Diphenhydramine; Surgical Procedures, Operative; Theophylline; Vomiting

1958
[Clinical experience with the antiemetic rodavan in the therapy of roentgen intoxication].
    Deutsches medizinisches Journal, 1958, Volume: 9, Issue:11

    Topics: Antiemetics; Caffeine; Diphenhydramine; Radiation Injuries; Radiotherapy; Theophylline

1958
8-(Dialkylaminoalkylamino)-caffeines as potential pharmacodynamic agents.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1959, Volume: 48, Issue:3

    Topics: Caffeine; Theophylline

1959
[Treatment of insomnia in asthmatics with hypnasmine].
    Praxis, 1960, Dec-29, Volume: 49

    Topics: Asthma; Barbiturates; Caffeine; Humans; Sleep Initiation and Maintenance Disorders; Theophylline

1960
[The action of caffeine, theobromine and theophylline on the isolated phrenicus-diaphragm preparation of the rat in different extracellular concentrations of potassium and calcium ions].
    Acta biologica et medica Germanica, 1961, Volume: 6

    Topics: Abdominal Muscles; Animals; Caffeine; Calcium; Calcium, Dietary; Diaphragm; Ions; Muscles; Potassium; Rats; Theobromine; Theophylline

1961
Common drugs that may invalidate spectrophotofluorometric assays of blood griseofulvin.
    The Journal of pharmacy and pharmacology, 1962, Volume: 14

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Biological Assay; Caffeine; Griseofulvin; Humans; Quinine; Theophylline

1962
Interaction of carrageenan and other hydrocolloids with alkaloids. II. Equilibrium dialysis studies.
    Journal of pharmaceutical sciences, 1962, Volume: 51

    Topics: Acacia; Alkaloids; Atropa belladonna; Caffeine; Carrageenan; Colloids; Dialysis; Methylcellulose; Parasympatholytics; Pectins; Polysaccharides; Quinine; Renal Dialysis; Resins, Synthetic; Theophylline

1962
[Studies on the coulometric determination of caffeine, theobromine and theophylline. I. Chlorocoulometric microdetermination of caffeine].
    Acta poloniae pharmaceutica, 1963, Volume: 20

    Topics: Caffeine; Theobromine; Theophylline

1963
[Some possibilities for the use of thin-layer chromatography without binding agents in drug analysis. 3. Qualitative detection of purines and barbiturates used in prescriptions].
    Die Pharmazie, 1963, Volume: 18

    Topics: Aminophylline; Barbiturates; Caffeine; Chromatography, Thin Layer; Phenobarbital; Purines; Substance Abuse Detection; Theobromine; Theophylline

1963
[Theomyl, a new synthetic asthma preparation].
    Svenska lakartidningen, 1962, Nov-15, Volume: 59

    Topics: Albuterol; Asthma; Caffeine; Epinephrine; Ipratropium; Theophylline

1962
[On the effect of caffeine and theophylline on the fatigued rat diaphragm preparation].
    Archives internationales de pharmacodynamie et de therapie, 1962, Aug-01, Volume: 138

    Topics: Animals; Caffeine; Diaphragm; Fatigue; Neuromuscular Junction; Rats; Theophylline

1962
DISSOLUTION BEHAVIOR OF CRYSTALLINE SOLVATED AND NONSOLVATED FORMS OF SOME PHARMACEUTICALS.
    Journal of pharmaceutical sciences, 1963, Volume: 52

    Topics: Caffeine; Chemistry, Pharmaceutical; Cholesterol; Fludrocortisone; Glutethimide; Pharmacy; Research; Solubility; Sulfathiazoles; Theophylline

1963
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE.
    Biochemical pharmacology, 1963, Volume: 12

    Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines

1963
STUDIES ON THE METHOD OF THERMAL ANALYSIS OF ORGANIC MEDICINALS. III. RELATIONS BETWEEN METHODS OF SAMPLE PREPARATION AND OBTAINED PHASE DIAGRAMS.
    Chemical & pharmaceutical bulletin, 1963, Volume: 11

    Topics: 4-Aminobenzoic Acid; Aminopyrine; Ammonium Compounds; Aniline Compounds; Barbiturates; Benzoates; Biphenyl Compounds; Caffeine; Chemistry Techniques, Analytical; Niacinamide; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Research; Theophylline

1963
[STUDY OF THE INTERMEDIATE METABOLISM OF DRUGS USING PARTIAL HEPATECTOMY].
    Kiserletes orvostudomany, 1963, Volume: 15

    Topics: Barbiturates; Caffeine; Chemical and Drug Induced Liver Injury; Chloralose; Hepatectomy; Hepatitis; Hypnotics and Sedatives; Insulin; Liver; Meperidine; Muscle Relaxants, Central; Pentylenetetrazole; Rats; Research; Splenectomy; Theophylline; Toxicology; Tranquilizing Agents; Urethane

1963
[EFFECTS OF VARIOUS NATURAL ORGANIC SUBSTANCES AND AMINO ACIDS ON THE BLOOD SURGAR LEVEL AND EXPERIMENTAL STUDIES ON ORAL HYPOGLYCEMIC AGENTS].
    Nihon Naibunpi Gakkai zasshi, 1963, Nov-20, Volume: 39

    Topics: Amino Acids; Animals; Bile Acids and Salts; Blood Chemical Analysis; Blood Glucose; Caffeine; Chlorpropamide; Creatine; Creatinine; Cystine; Diabetes Mellitus, Experimental; Hippurates; Hypoglycemic Agents; Injections; Injections, Intravenous; Metformin; Pathology; Pharmacology; Rats; Research; Salts; Theobromine; Theophylline; Tyrosine

1963
MUTATIONAL SYNERGISM BETWEEN RADIATIONS AND METHYLATED PURINES IN ESCHERICHIA COLI.
    Journal of bacteriology, 1964, Volume: 87

    Topics: Caffeine; Escherichia coli; Light; Mutation; Pharmacology; Purines; Research; Streptomycin; Theobromine; Theophylline; Ultraviolet Rays

1964
[INCIDENTS IN REID'S INTRACISTERNAL THERAPY WITH PROCAINE-CAFFEINE MIXTURES].
    Die Medizinische Welt, 1963, Nov-23, Volume: 47

    Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Caffeine; Encephalomyelitis; Epilepsy; Headache; Injections; Injections, Spinal; Jurisprudence; Neurologic Manifestations; Procaine; Spinal Diseases; Strophanthins; Subarachnoid Space; Theophylline; Therapeutics; Toxicology

1963
DEMETHYLATION OF PURINE ANALOGS BY MICROSOMAL ENZYMES FROM MOUSE LIVER.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Antimetabolites; Caffeine; Carcinoma; Carcinoma, Ehrlich Tumor; Liver; Mercaptopurine; Metabolism; Mice; Purines; Pyrimidines; Research; Sulfhydryl Compounds; Theobromine; Theophylline

1964
[ON ISOLATED ALLERGIC MYOCARDITIS].
    Sovetskaia meditsina, 1964, Volume: 27

    Topics: Asthma; Bronchitis; Caffeine; Cardiac Complexes, Premature; Drug Therapy; Electrocardiography; Epinephrine; Geriatrics; Goiter; Graves Disease; Hypertension; Myocarditis; Theophylline

1964
THE ANTI-ANAPHYLACTIC ACTIVITY OF THEOPHYLLINE AND SOME RELATED XANTHINE DERIVATIVES.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Anaphylaxis; Anti-Allergic Agents; Caffeine; Diuretics; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Lipids; Lung; Pharmacology; Research; Theobromine; Theophylline; Xanthine; Xanthines

1964
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES.
    Archives of biochemistry and biophysics, 1964, Volume: 105

    Topics: Caffeine; Guanine; Guanine Nucleotides; Hydrogen-Ion Concentration; Hypoxanthines; Infrared Rays; Light; Manometry; Methylene Blue; Nucleosides; Oxidation-Reduction; Purines; Research; Theobromine; Theophylline; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uric Acid; Xanthines

1964
ACTIVATION OF AN EPINEPHRINE-SENSITIVE LIPOLYTIC ACTIVITY FROM ADIPOSE TISSUE BY ADENOSINE 3',5'-PHOSPHATE.
    The Journal of biological chemistry, 1964, Volume: 239

    Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adipose Tissue; Caffeine; Calcium; Epididymis; Epinephrine; Humans; Lipid Metabolism; Lipolysis; Male; Pharmacology; Phosphates; Rats; Research; Theophylline

1964
POTENTIATION OF DIURETIC EFFECTS OF METHYL XANTHINES AND PYRIMIDINES BY CARBONIC ANHYDRASE INHIBITORS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 144

    Topics: Acetazolamide; Aminophylline; Animals; Caffeine; Carbonates; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chlorine; Diuretics; Dogs; Enzyme Inhibitors; Hydrochlorothiazide; Kidney; Pharmacology; Physiology; Potassium; Pyrimidines; Research; Sodium; Sulfonamides; Theophylline; Water-Electrolyte Balance; Xanthines

1964
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID].
    Annales pharmaceutiques francaises, 1964, Volume: 22

    Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology

1964
MECHANISM OF MELANOPHORE DISPERSION.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Adrenocorticotropic Hormone; Animals; Anura; Arsenicals; Benzoates; Caffeine; Calcium Chloride; Chromatophores; Cyanides; Fluoroacetates; Glyceraldehyde; Iodoacetates; Melanocyte-Stimulating Hormones; Melanophores; Mercury; Norepinephrine; Pharmacology; Pigmentation; Potassium; Research; Theobromine; Theophylline

1964
DARK REPAIR OF UV INDUCTION IN K12 (LAMBDA).
    Virology, 1964, Volume: 23

    Topics: Acridines; Caffeine; Coliphages; DNA; DNA, Viral; Escherichia coli; Mutation; Pharmacology; Proteins; Purines; Radiation Genetics; Research; RNA; RNA, Viral; Theophylline; Ultraviolet Rays

1964
THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM.
    British journal of pharmacology and chemotherapy, 1964, Volume: 23

    Topics: Caffeine; Calcium Chloride; Carbohydrate Metabolism; Diaphragm; Dopamine; Ephedrine; Epinephrine; Glucagon; Hexosephosphates; Insulin; Iodoacetates; Isoproterenol; Muscle, Smooth; Muscles; Norepinephrine; Pharmacology; Phlorhizin; Rats; Research; Sympathomimetics; Theophylline; Tyramine

1964
[TETRONIC ACIDS. 4. TETRONIC ACID DERIVATIVES AS SOLVENTS FOR DRUGS DIFFICULT TO DISSOLVE IN WATER].
    Arzneimittel-Forschung, 1963, Volume: 13

    Topics: Caffeine; Chemistry, Pharmaceutical; Furans; Khellin; Pyrazoles; Research; Solubility; Solvents; Steroids; Theophylline; Water

1963
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists; Mice; Piperidines; Pregnancy; Pregnancy, Animal; Research; Thalidomide; Theophylline; Toxicology

1964
ASSIGNMENT OF THE N-METHYL HYDROGEN NMR PEAKS OF CAFFEINE.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Caffeine; Chemistry, Pharmaceutical; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pharmacy; Research; Theobromine; Theophylline

1964
EFFECT OF XANTHINES AND HISTAMINE ON ION TRANSPORT AND RESPIRATION BY FROG GASTRIC MUCOSA.
    The American journal of physiology, 1965, Volume: 208

    Topics: Anura; Caffeine; Chlorides; Epithelium; Fatty Acids; Gastric Juice; Gastric Mucosa; Glucuronates; Histamine; Ion Exchange; Ion Transport; Metabolism; Muscle, Smooth; Pharmacology; Research; Stomach; Theobromine; Theophylline; Xanthines

1965
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. V. CHLOROCOULOMETRIC MICRODETERMINATION OF THEOPHYLLINE AFTER ALKALINE HYDROLYSIS].
    Acta poloniae pharmaceutica, 1964, Volume: 21

    Topics: Caffeine; Hydrolysis; Research; Theobromine; Theophylline

1964
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. VI. CHLOROCOULOMETRIC MICRODETERMINATION OF COMPONENTS IN A MIXTURE OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE].
    Acta poloniae pharmaceutica, 1964, Volume: 21

    Topics: Caffeine; Research; Theobromine; Theophylline

1964
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. 3. CHLORO-COULOMETRIC MICRODETERMINATION OF CAFFEINE AFTER ITS ALKALINE HYDROLYSIS WITH THE USE OF 2 METHODS].
    Acta poloniae pharmaceutica, 1964, Volume: 21

    Topics: Caffeine; Chemistry Techniques, Analytical; Hydrolysis; Microchemistry; Research; Theobromine; Theophylline

1964
[STUDIES ON THE COULOMETRIC DETERMINATION OF CAFFEINE, THEOBROMINE AND THEOPHYLLINE. IV. BROMO-COULOMETRIC MICRODETERMINATION OF CAFFEINE AFTER ALKALINE HYDROLYSIS].
    Acta poloniae pharmaceutica, 1964, Volume: 21

    Topics: Caffeine; Chemistry Techniques, Analytical; Hydrolysis; Microchemistry; Research; Theobromine; Theophylline

1964
EFFECT OF NATURALLY OCCURRING XANTHINES ON BACTERIA. I. ANTIMICROBIAL ACTION AND POTENTIATING EFFECT ON ANTIBIOTIC SPECTRA.
    Applied microbiology, 1965, Volume: 13

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacillus subtilis; Bacteria; Caffeine; Candida; Citrates; Corynebacterium diphtheriae; Enterobacter; Enterobacter aerogenes; Escherichia coli; Klebsiella; Mycobacterium; Pharmacology; Proteus; Pseudomonas aeruginosa; Research; Salmonella paratyphi A; Salmonella typhi; Sarcina; Shigella dysenteriae; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline; Theobromine; Theophylline; Xanthines

1965
THE EFFECTS OF THE ELECTRICAL STIMULATION OF THE BRACHIAL PLEXUS ON THE POTENTIAL DIFFERENCE OF FROG SKIN.
    Comparative biochemistry and physiology, 1965, Volume: 14

    Topics: Acetazolamide; Acetylcholine; Animals; Anura; Arginine Vasopressin; Atropine; Brachial Plexus; Caffeine; Cocaine; Electric Stimulation; Electrophysiology; Epinephrine; Neostigmine; Norepinephrine; Papaverine; Pharmacology; Physostigmine; Pilocarpine; Research; Skin; Theophylline; Tubocurarine; Vasopressins

1965
[Henodynamic effect of purine bodies in unanesthetized dog; comparative studies on caffeine, theobromine, theophylline, euphylline, hydroxyethyltheophylline and dihydroxypropyltheophylline].
    Arzneimittel-Forschung, 1955, Volume: 5, Issue:4

    Topics: Aminophylline; Animals; Caffeine; Dogs; Dyphylline; Ethylenediamines; Purines; Theobromine; Theophylline; Xanthines

1955
[Prophylaxis and therapy of postoperative vomiting with the diphenhydramine derivative combination Rodavan; a clinical-statistical evaluation].
    Der Anaesthesist, 1961, Volume: 10

    Topics: Caffeine; Diphenhydramine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Theophylline; Vomiting

1961
Regarding "An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years".
    Annals of epidemiology, 2004, Volume: 14, Issue:1

    Topics: Abortion, Spontaneous; Adult; Bias; Caffeine; Female; Humans; Pregnancy; Risk Factors; Sodium; Specimen Handling; Theophylline; Time Factors

2004
Repeatability and reproducibility of high-concentration data in reversed-phase liquid chromatography. III. Isotherm reproducibility on Kromasil C18.
    Journal of chromatography. A, 2004, Jan-23, Volume: 1024, Issue:1-2

    Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chromatography, Liquid; Phenol; Propranolol; Reproducibility of Results; Theophylline; Thermodynamics

2004
[Comparison of the effect of some puric alkaloids (caffeine, theobromine, theophylline and theophylline-ethylenediamine) on cholinesterase].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1950, Volume: 144, Issue:13-14

    Topics: Alkaloids; Aminophylline; Caffeine; Cholinesterases; Humans; Theobromine; Theophylline

1950
Comments on the paper: Effect and specificity of certain histamine antagonists studied on the isolated small intestine of the guinea-pig by L. C. Grandjean.
    Acta pharmacologica et toxicologica, 1951, Volume: 7, Issue:2

    Topics: Caffeine; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Intestine, Small; Intestines; Theophylline

1951
The effect of methylxanthines on the hypocoagulability induced by chloroform in the dog.
    Blood, 1952, Volume: 7, Issue:4

    Topics: Animals; Caffeine; Chloroform; Dogs; Hemostatics; Prothrombin; Theobromine; Theophylline; Xanthines

1952
Component analysis of illicit heroin samples with GC/MS and its application in source identification.
    Journal of forensic sciences, 2004, Volume: 49, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Codeine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Heroin; Illicit Drugs; Morphine Derivatives; Narcotics; Theophylline; Vasodilator Agents

2004
Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure.
    Journal of neurochemistry, 2004, Volume: 88, Issue:5

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Time; Xanthines

2004
Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography.
    Journal of chromatography. A, 2004, Mar-19, Volume: 1030, Issue:1-2

    Topics: Automation; Caffeine; Chromatography, High Pressure Liquid; Polymers; Theobromine; Theophylline

2004
Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography.
    Journal of agricultural and food chemistry, 2004, Jun-02, Volume: 52, Issue:11

    Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Reference Standards; Theobromine; Theophylline

2004
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
    Biochemical and biophysical research communications, 2004, Jul-16, Volume: 320, Issue:1

    Topics: Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fluoresceins; Humans; Organic Anion Transporters; Theophylline; Xanthines

2004
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.
    International immunopharmacology, 2004, Volume: 4, Issue:10-11

    Topics: Adult; Caffeine; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-10; Interleukin-12; Lipopolysaccharides; Theophylline; Tumor Necrosis Factor-alpha

2004
Simultaneous determination of caffeine, theophylline and theobromine in human plasma by on-line solid-phase extraction coupled to reversed-phase chromatography.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:8

    Topics: Buffers; Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methanol; Phosphates; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Theobromine; Theophylline

2004
[Methylxanthines in the group of potassium sensitizers].
    Archives internationales de physiologie, 1950, Volume: 57, Issue:3

    Topics: Caffeine; Humans; Nervous System Physiological Phenomena; Physiology; Potassium; Theobromine; Theophylline; Xanthines

1950
Genetic screens and selections for small molecules based on a synthetic riboswitch that activates protein translation.
    Journal of the American Chemical Society, 2004, Oct-20, Volume: 126, Issue:41

    Topics: 5' Untranslated Regions; Caffeine; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Messenger; Theophylline; Xanthines

2004
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.
    Journal of neurochemistry, 2004, Volume: 91, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Synaptic Transmission; Theophylline

2004
Vibrational spectral investigation on xanthine and its derivatives--theophylline, caffeine and theobromine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2005, Jan-01, Volume: 61, Issue:1-2

    Topics: Caffeine; Carbon; Hydrogen; Kinetics; Molecular Structure; Nitrogen; Oxygen; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theobromine; Theophylline; Vibration; Xanthines

2005
Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Anesthesia; Animals; Caffeine; Diuretics; Genotype; Glomerular Filtration Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Natriuresis; Potassium; Receptor, Adenosine A1; Sodium; Theophylline; Urodynamics

2005
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.
    British journal of pharmacology, 2005, Volume: 144, Issue:5

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Intraperitoneal; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines

2005
Effect of caffeine on cerebral blood flow response to somatosensory stimulation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6

    Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation; Electric Stimulation; Injections, Intravenous; Male; Physical Stimulation; Pia Mater; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Somatosensory Cortex; Theophylline; Vasodilation; Vasodilator Agents

2005
Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain.
    Neuroscience, 2005, Volume: 131, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenylyl Cyclases; Animals; Brain; Caffeine; Female; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptor, Adenosine A1; Theophylline

2005
Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Riluzole; Theophylline

2005
Stabilizing effects of extracellular ATP on synaptic efficacy and plasticity in hippocampal pyramidal neurons.
    The European journal of neuroscience, 2005, Volume: 21, Issue:4

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Caffeine; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Extracellular Space; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Purinergic P2 Receptor Antagonists; Pyramidal Cells; Pyridoxal Phosphate; Rats; Rats, Wistar; Synaptic Transmission; Theophylline; Time Factors

2005
Raman spectroscopic characterisations and analytical discrimination between caffeine and demethylated analogues of pharmaceutical relevance.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2005, Volume: 61, Issue:7

    Topics: Alkaloids; Caffeine; Models, Chemical; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline; Xanthine

2005
Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.
    Virology, 2005, May-10, Volume: 335, Issue:2

    Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line; Cells, Cultured; DNA-Binding Proteins; HIV-1; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Theophylline; Time Factors; Tumor Suppressor Proteins; Virus Replication; Xanthines

2005
Monitoring bronchodilators with direct injection.
    Journal of chromatography. A, 2005, May-06, Volume: 1073, Issue:1-2

    Topics: Bronchodilator Agents; Caffeine; Calibration; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Theophylline

2005
Inhibition of human TREK-1 channels by caffeine and theophylline.
    Epilepsy research, 2005, Volume: 64, Issue:3

    Topics: Animals; Caffeine; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Mutation; Potassium Channels, Tandem Pore Domain; Theophylline

2005
Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:9

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Escherichia coli; Female; Genotype; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Theophylline

2005
Effect of chronic gestational treatment with caffeine or theophylline on Group I metabotropic glutamate receptors in maternal and fetal brain.
    Journal of neurochemistry, 2005, Volume: 94, Issue:2

    Topics: Animals; Blotting, Western; Brain; Caffeine; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Methoxyhydroxyphenylglycol; Phosphodiesterase Inhibitors; Phospholipase C beta; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Type C Phospholipases

2005
Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone.
    Acta biochimica Polonica, 2005, Volume: 52, Issue:4

    Topics: Antimutagenic Agents; Caffeine; Cell Survival; Daunorubicin; Doxorubicin; Mitoxantrone; Mutagenicity Tests; Pentoxifylline; Structure-Activity Relationship; Theophylline; Vibrio; Xanthenes

2005
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7

    Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene

2005
Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites.
    Biochimica et biophysica acta, 2005, Aug-15, Volume: 1714, Issue:2

    Topics: Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Cricetulus; Humans; Molecular Structure; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Theobromine; Theophylline; Uric Acid; Xanthines

2005
Study for luminescence performance of three methyl xanthine derivatives.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2005, Volume: 61, Issue:11-12

    Topics: Caffeine; Fluorescence; Hydrogen-Ion Concentration; Luminescent Measurements; Molecular Structure; Spectrometry, Fluorescence; Temperature; Theobromine; Theophylline; Xanthines

2005
Comment on vibrational spectral investigation on xanthine and its derivatives-theophylline, caffeine and theobromine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2005, Volume: 61, Issue:11-12

    Topics: Caffeine; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theobromine; Theophylline; Vibration

2005
Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.
    Molecular carcinogenesis, 2005, Volume: 44, Issue:1

    Topics: Animals; Caffeine; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Theophylline; Transcription Factor AP-1

2005
Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats.
    Nature, 1977, May-12, Volume: 267, Issue:5607

    Topics: Animals; Blood Glucose; Body Weight; Caffeine; Deoxyglucose; Eating; Feeding Behavior; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Theophylline; Xanthenes

1977
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; Animals; Butadienes; Caffeine; Female; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Purines; Rabbits; Receptors, Purinergic P1; Theophylline; Wortmannin; Xanthines

2006
A structural study of new potent and selective antagonists to the A2B adenosine receptor.
    Acta crystallographica. Section B, Structural science, 2005, Volume: 61, Issue:Pt 5

    Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Asparagine; Caffeine; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Histidine; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Theophylline; Xanthines

2005
Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Caco-2 Cells; Caffeine; Catechin; Corticosterone; Food-Drug Interactions; Humans; Intestinal Absorption; Intestinal Mucosa; Organic Cation Transport Proteins; Plant Extracts; Quinolines; Tea; Theophylline; Tritium

2005
Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:10

    Topics: Adult; Antimalarials; Antinematodal Agents; Area Under Curve; Artemisinins; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Mass Spectrometry; Middle Aged; Theophylline; Thiabendazole

2005
Separation of caffeine and theophylline in poly(dimethylsiloxane) microchannel electrophoresis with electrochemical detection.
    Journal of chromatography. A, 2005, Dec-09, Volume: 1098, Issue:1-2

    Topics: Animals; Caffeine; Dimethylpolysiloxanes; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Rats; Reproducibility of Results; Sensitivity and Specificity; Theophylline

2005
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha

2006
Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Caffeine; Cytochrome P-450 CYP1A2; Delayed-Action Preparations; Female; Genotype; Humans; Japan; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Pulmonary Disease, Chronic Obstructive; Smoking; Theophylline

2006
Spectrophotometric determination of caffeine and theophylline in pure alkaloids and its application in pharmaceutical formulations.
    Analytical biochemistry, 2006, Feb-15, Volume: 349, Issue:2

    Topics: Alkaloids; Caffeine; Pharmaceutical Preparations; Reproducibility of Results; Spectrophotometry; Tablets; Theophylline

2006
Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Journal of applied genetics, 2006, Volume: 47, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminoacridines; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Caffeine; Central Nervous System Stimulants; Doxorubicin; Free Radical Scavengers; Mutagenicity Tests; Neurotoxins; Nitrogen Mustard Compounds; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Vibrio

2006
Serum sickness-like reaction to Pamabrom.
    Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:3

    Topics: Adult; Arm; Aspirin; Caffeine; Diagnosis, Differential; Drug Combinations; Ephedrine; Female; Humans; Leg; Phenacetin; Propanolamines; Serum Sickness; Theophylline

2006
In vitro transdermal delivery of caffeine, theobromine, theophylline and catechin from extract of Guarana, Paullinia Cupana.
    International journal of pharmaceutics, 2006, Jul-06, Volume: 317, Issue:1

    Topics: Adhesives; Administration, Cutaneous; Animals; Caffeine; Catechin; In Vitro Techniques; Paullinia; Plant Extracts; Polyethylene Glycols; Propylene Glycol; Skin; Skin Absorption; Swine; Theobromine; Theophylline; Water

2006
Differential effect of selected methylxanthine derivatives on radiosensitization of lung carcinoma cells.
    Experimental oncology, 2006, Volume: 28, Issue:1

    Topics: Apoptosis; Caffeine; Carcinoma, Large Cell; Cell Line, Tumor; Cell Survival; Flow Cytometry; Gamma Rays; Humans; Lung Neoplasms; Radiation-Sensitizing Agents; Theophylline; Xanthines

2006
Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.
    American journal of epidemiology, 2006, Jun-01, Volume: 163, Issue:11

    Topics: Adult; Biomarkers; Caffeine; Chi-Square Distribution; Connecticut; Cytochrome P-450 Enzyme System; Female; Fetal Blood; Fetal Growth Retardation; Humans; Massachusetts; Maternal-Fetal Exchange; Mothers; Pregnancy; Pregnancy Outcome; Risk Factors; Statistics, Nonparametric; Theobromine; Theophylline

2006
Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.
    Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:5

    Topics: Abdominal Fat; Animals; Body Weight; Caffeine; Cholesterol; Diet; Dietary Fats; Eating; Liver; Male; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Triglycerides; Xanthines

2006
Application of a sample pooling method for the accelerated assessment of the rate of uptake of drugs by the brain in rats.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:6

    Topics: Animals; Brain; Caffeine; Male; Metabolic Clearance Rate; Microdialysis; Rats; Rats, Sprague-Dawley; Theophylline

2006
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines

2006
Enzymatic erosion of bioartificial membranes to control drug delivery.
    Macromolecular bioscience, 2006, Jun-16, Volume: 6, Issue:6

    Topics: Biocompatible Materials; Buffers; Caffeine; Chemistry, Pharmaceutical; Cross-Linking Reagents; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Membranes, Artificial; Microscopy, Electron, Scanning; Polyvinyl Alcohol; Solubility; Solutions; Starch; Temperature; Theophylline; Water

2006
Fluid bed drying of guarana (Paullinia cupana HBK) extract: effect of process factors on caffeine content.
    AAPS PharmSciTech, 2006, Jun-16, Volume: 7, Issue:2

    Topics: Caffeine; Desiccation; Drug Compounding; Plant Extracts; Rheology; Theobromine; Theophylline

2006
[Study on interaction of caffeine and theophylline with bovine serum albumins].
    Guang pu xue yu guang pu fen xi = Guang pu, 2006, Volume: 26, Issue:3

    Topics: Animals; Caffeine; Cattle; Central Nervous System Stimulants; Kinetics; Protein Binding; Serum Albumin, Bovine; Spectrometry, Fluorescence; Theophylline; Vasodilator Agents

2006
Characteristics of thiamine uptake by the BeWo human trophoblast cell line.
    Journal of biochemistry and molecular biology, 2006, Jul-31, Volume: 39, Issue:4

    Topics: Biological Transport; Caffeine; Cell Line, Tumor; Cell Membrane Structures; Ethanol; Female; Flavonoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Phenols; Placenta; Polyphenols; Pregnancy; Serotonin Plasma Membrane Transport Proteins; Temperature; Theophylline; Thiamine; Trophoblasts

2006
Computationally-assisted approach to the vibrational spectra of molecular crystals: study of hydrogen-bonding and pseudo-polymorphism.
    Chemphyschem : a European journal of chemical physics and physical chemistry, 2006, Oct-13, Volume: 7, Issue:10

    Topics: Caffeine; Computer Simulation; Crystallization; Hydrogen Bonding; Models, Molecular; Molecular Structure; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline; Vibration

2006
Characteristic of theophylline imprinted monolithic column and its application for determination of xanthine derivatives caffeine and theophylline in green tea.
    Journal of chromatography. A, 2006, Nov-17, Volume: 1134, Issue:1-2

    Topics: Adsorption; Caffeine; Polymers; Tea; Temperature; Theophylline; Thermodynamics

2006
A simple fluorescent biosensor for theophylline based on its RNA aptamer.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:12

    Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; DNA; Dose-Response Relationship, Drug; Fluorescent Dyes; Models, Chemical; Nucleic Acid Conformation; Nucleic Acid Hybridization; RNA; Spectrometry, Fluorescence; Temperature; Theophylline

2006
Characterization of anhydrous and hydrated pharmaceutical materials with THz time-domain spectroscopy.
    Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:4

    Topics: Ampicillin; Caffeine; Chemistry, Pharmaceutical; Glucose; Hydrogen Bonding; Spectrum Analysis; Theophylline; Water; X-Ray Diffraction

2007
Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals.
    Chemical communications (Cambridge, England), 2006, Dec-28, Issue:48

    Topics: Caffeine; Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Methane; Models, Molecular; Molecular Structure; Nitroparaffins; Stereoisomerism; Tartrates; Theophylline

2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines

2007
Awareness and use of caffeine by athletes competing at the 2005 Ironman Triathlon World Championships.
    International journal of sport nutrition and exercise metabolism, 2006, Volume: 16, Issue:5

    Topics: Adult; Awareness; Bicycling; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Humans; Male; Physical Endurance; Prevalence; Running; Surveys and Questionnaires; Swimming; Theophylline

2006
Effect of methylxanthines on production of cellulases by Penicillium echinulatum.
    Journal of applied microbiology, 2007, Volume: 102, Issue:2

    Topics: Aminophylline; beta-Glucosidase; Bioreactors; Caffeine; Cellulases; Culture Media; Glucose; Industrial Microbiology; Penicillium; Theophylline; Xanthines

2007
Pathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:2

    Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Caffeine; Calcium; Cell Line; Cyclic AMP; DNA Fragmentation; Epithelium, Corneal; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphorylation; Rabbits; Theophylline; Ultraviolet Rays; Wortmannin

2007
Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments.
    Journal of neurochemistry, 2007, Volume: 101, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Adenosine A1; Synaptic Transmission; Theophylline

2007
Extraction of radio-labelled xanthine derivatives by artificial receptors: deep insight into the association behaviour.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:13

    Topics: Binding Sites; Binding, Competitive; Caffeine; Crystallography, X-Ray; Methylene Chloride; Models, Molecular; Molecular Structure; Radioisotopes; Receptors, Peptide; Solvents; Theophylline; Toluene; Xanthines

2007
Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility.
    International journal of pharmaceutics, 2007, Jul-18, Volume: 339, Issue:1-2

    Topics: Acrylates; Caffeine; Delayed-Action Preparations; Diffusion; Gels; Polyethylene Glycols; Solubility; Theophylline

2007
Guiding bacteria with small molecules and RNA.
    Journal of the American Chemical Society, 2007, May-30, Volume: 129, Issue:21

    Topics: Aptamers, Nucleotide; Bacterial Proteins; Caffeine; Chemotaxis; Escherichia coli; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; RNA, Bacterial; Signal Transduction; Theophylline

2007
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3).
    Biochimica et biophysica acta, 2007, Volume: 1768, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline

2007
Transdermal and buccal delivery of methylxanthines through human tissue in vitro.
    Drug development and industrial pharmacy, 2007, Volume: 33, Issue:5

    Topics: Administration, Buccal; Administration, Cutaneous; Caffeine; Central Nervous System Stimulants; Excipients; Humans; In Vitro Techniques; Mouth Mucosa; Oleic Acid; Permeability; Skin; Skin Absorption; Solubility; Theobromine; Theophylline; Xanthenes

2007
Death by chocolate: a fatal problem for an inquisitive wild parrot.
    New Zealand veterinary journal, 2007, Volume: 55, Issue:3

    Topics: Animals; Animals, Wild; Cacao; Caffeine; Fatal Outcome; Male; Parrots; Theobromine; Theophylline; Xanthines

2007
Caffeine intake and small-for-gestational-age birth: modifying effects of xenobiotic-metabolising genes and smoking.
    Paediatric and perinatal epidemiology, 2007, Volume: 21, Issue:4

    Topics: Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Risk Factors; Smoking; Theophylline

2007
Involvement of adenosinergic receptors in anxiety related behaviours.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:5

    Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Male; Maze Learning; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline

2007
Development of in-tube solid-phase microextraction coupled to pressure-assisted CEC and its application to the analysis of propranolol enantiomers in human urine.
    Electrophoresis, 2007, Volume: 28, Issue:15

    Topics: Caffeine; Capillary Electrochromatography; Pressure; Propranolol; Solid Phase Microextraction; Theobromine; Theophylline

2007
Engineering high-speed allosteric hammerhead ribozymes.
    Biological chemistry, 2007, Volume: 388, Issue:8

    Topics: Allosteric Regulation; Allosteric Site; Animals; Base Sequence; Caffeine; Cell Line; Clone Cells; Gene Expression Regulation; Genetic Engineering; Humans; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Regulatory Sequences, Ribonucleic Acid; RNA, Catalytic; Schistosoma mansoni; SELEX Aptamer Technique; Sequence Analysis, RNA; Theophylline

2007
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008, Volume: 28, Issue:2

    Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Ethanol; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Male; Prospective Studies; Theobromine; Theophylline; Treatment Outcome

2008
Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.
    Electrophoresis, 2007, Volume: 28, Issue:19

    Topics: Anions; Beverages; Binding Sites; Caffeine; Chlorogenic Acid; Cinnamates; Coffee; Electric Conductivity; Electrophoresis, Capillary; Hydrophobic and Hydrophilic Interactions; Kinetics; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrophotometry, Ultraviolet; Theobromine; Theophylline

2007
Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years.
    Chemosphere, 2008, Volume: 70, Issue:10

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Caffeine; Child; Cytochrome P-450 CYP1A2; Dioxins; Environmental Exposure; Environmental Pollutants; Female; Follow-Up Studies; Humans; Lactation; Liver; Male; Maternal-Fetal Exchange; Netherlands; Pregnancy; Theophylline; Thyrotropin; Thyroxine

2008
Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 32, Issue:3

    Topics: Alginates; Caffeine; Calcium Compounds; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Gels; Kinetics; Particle Size; Pectins; Pharmaceutical Preparations; Solubility; Surface Properties; Theobromine; Theophylline

2007
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
    Drug development and industrial pharmacy, 2007, Volume: 33, Issue:9

    Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity

2007
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:1

    Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Genotype; Growth Disorders; Human Growth Hormone; Humans; Injections, Subcutaneous; Male; Mixed Function Oxygenases; Recombinant Proteins; Theophylline; Uric Acid

2008
Inelastic neutron scattering study of methyl groups rotation in some methylxanthines.
    The Journal of chemical physics, 2007, Dec-07, Volume: 127, Issue:21

    Topics: Caffeine; Methylation; Models, Chemical; Models, Molecular; Neutron Diffraction; Rotation; Spectrum Analysis; Theobromine; Theophylline; Thermodynamics; Xanthines

2007
The spectrophotometric determination of the dissociation constants of theophylline, theobromine, and caffeine.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1949, Volume: 38, Issue:3 Pt. 1

    Topics: Caffeine; Humans; Spectrophotometry; Theobromine; Theophylline

1949
Action of caffeine and aminophylline as respiratory stimulants in man.
    Journal of applied physiology, 1949, Volume: 2, Issue:1

    Topics: Aminophylline; Caffeine; Humans; Male; Respiratory System Agents; Theophylline

1949
Salivary aldehyde dehydrogenase--reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method.
    Archives of oral biology, 2008, Volume: 53, Issue:5

    Topics: Adult; Aldehyde Dehydrogenase; Aldehydes; Caffeine; Fluorometry; Glutathione; Humans; Kinetics; Middle Aged; NAD; NADP; Naphthalenes; Oxidation-Reduction; Saliva; Theophylline

2008
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
    European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines

2008
Assessing caffeine exposure in pregnant women.
    The British journal of nutrition, 2008, Volume: 100, Issue:4

    Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Prospective Studies; Saliva; Sensitivity and Specificity; Surveys and Questionnaires; Theophylline

2008
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
    Journal of chromatographic science, 2008, Volume: 46, Issue:2

    Topics: Acetaminophen; Antipyrine; Aspirin; Beverages; Biological Products; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Codeine; Cosmetics; Food Analysis; Linear Models; Pharmaceutical Preparations; Salicylic Acid; Theobromine; Theophylline

2008
Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
    Journal of chromatographic science, 2008, Volume: 46, Issue:2

    Topics: Beverages; Caffeine; Chromatography, High Pressure Liquid; Food Analysis; Plant Preparations; Theobromine; Theophylline; Xanthines

2008
Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?
    Chemical communications (Cambridge, England), 2008, Apr-14, Issue:14

    Topics: Caffeine; Crystallization; Crystallography, X-Ray; Drug Stability; Hydrogen Bonding; Malates; Molecular Structure; Stereoisomerism; Tartrates; Theophylline; Water

2008
Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse.
    Journal of biochemistry, 2008, Volume: 144, Issue:2

    Topics: Acetaldehyde; Amphetamine; Biological Transport; Caffeine; Cell Line, Tumor; Cell Survival; Choriocarcinoma; Cytochalasin B; Deoxyglucose; Diet; Dronabinol; Ethanol; Flavonoids; Glucose; Humans; Illicit Drugs; Kinetics; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Phenols; Polyphenols; Theophylline; Trophoblasts

2008
In vitro reactivity of urinary bladder smooth muscle in rabbits influenced by xanthine derivatives.
    Bratislavske lekarske listy, 2008, Volume: 109, Issue:3

    Topics: Acetylcholine; Animals; Caffeine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rabbits; Theophylline; Urinary Bladder

2008
Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
    Molecular pharmacology, 2008, Volume: 74, Issue:4

    Topics: Animals; Apoptosis; Caffeine; Cell Death; Cell Survival; Cells, Cultured; Dopamine; Embryo, Mammalian; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; Mesencephalon; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Solubility; Theophylline

2008
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.
    Human & experimental toxicology, 2008, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Contraceptives, Oral; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Phenotype; Risk Factors; Sex Factors; Smoking; Spain; Theophylline; Uric Acid

2008
Surface-imprinted nanostructured layer-by-layer film for molecular recognition of theophylline derivatives.
    Langmuir : the ACS journal of surfaces and colloids, 2008, Oct-21, Volume: 24, Issue:20

    Topics: Acrylic Resins; Caffeine; Chemistry, Physical; Cross-Linking Reagents; Disulfides; Kinetics; Light; Models, Chemical; Nanoparticles; Nanotechnology; Polymers; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Surface Properties; Theophylline

2008
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 398, Issue:1-2

    Topics: Acetaminophen; Analgesics; Anticonvulsants; Bronchodilator Agents; Caffeine; Calibration; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Histamine H2 Antagonists; Humans; Infant, Newborn; Phenytoin; Quality Control; Ranitidine; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline

2008
Vibrational spectra of anhydrous and monohydrated caffeine and theophylline molecules and crystals.
    The journal of physical chemistry. A, 2008, Oct-16, Volume: 112, Issue:41

    Topics: Caffeine; Computer Simulation; Hydrogen Bonding; Models, Chemical; Spectrophotometry, Infrared; Theophylline; Vibration; Water

2008
New syntheses of caffeine and theophylline.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1948, Volume: 37, Issue:2

    Topics: Caffeine; Theophylline

1948
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation.
    Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24

    Topics: Biosensing Techniques; Caffeine; Chemistry, Pharmaceutical; Colorimetry; Cross-Linking Reagents; DNA; Dose-Response Relationship, Drug; Drug Design; Gold; Metal Nanoparticles; Molecular Conformation; Nanotechnology; Nucleic Acid Hybridization; Sensitivity and Specificity; Theophylline

2008
Modulation of butyrate transport in Caco-2 cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:4

    Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetaldehyde; Acids, Acyclic; Aspirin; Biological Transport, Active; Butyrates; Caco-2 Cells; Caffeine; Cell Survival; Dronabinol; Gene Expression; Humans; Hydrogen-Ion Concentration; Indomethacin; Ions; Kinetics; Monocarboxylic Acid Transporters; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Azide; Symporters; Theophylline

2009
Determination of hydrate transition temperature using transformation kinetics obtained by Raman spectroscopy.
    Journal of pharmaceutical and biomedical analysis, 2009, Feb-20, Volume: 49, Issue:2

    Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Kinetics; Molecular Structure; Molecular Weight; Phase Transition; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; Theophylline; Thermodynamics; Time Factors; Transition Temperature; Water

2009
Fluorescence emission properties of 8-aza analogues of caffeine, theophylline, and related N-alkyl xanthines.
    Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6

    Topics: Aza Compounds; Caffeine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Xanthines

2009
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.
    Liver international : official journal of the International Association for the Study of the Liver, 2009, Volume: 29, Issue:6

    Topics: Animals; Blotting, Western; Caffeine; Cells, Cultured; Connective Tissue Growth Factor; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Hepatocytes; Inhibitory Concentration 50; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Theobromine; Theophylline

2009
Application and analysis of structure-switching aptamers for small molecule quantification.
    Analytica chimica acta, 2009, Apr-13, Volume: 638, Issue:2

    Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; Nucleic Acid Conformation; Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Theophylline

2009
Grafting of molecularly imprinted polymers on iniferter-modified carbon nanotube.
    Biosensors & bioelectronics, 2009, Nov-15, Volume: 25, Issue:3

    Topics: Binding Sites; Biosensing Techniques; Caffeine; Kinetics; Microscopy, Electron, Scanning; Molecular Imprinting; Molecular Structure; Nanotubes, Carbon; Polymers; Theobromine; Theophylline

2009
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
    Current drug safety, 2009, Volume: 4, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analgesics, Opioid; Animals; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Phenethylamines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinidine; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P2; Substance Withdrawal Syndrome; Theobromine; Theophylline

2009
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
    Journal of bacteriology, 2009, Volume: 191, Issue:14

    Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines

2009
Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.
    Pharmacogenomics, 2009, Volume: 10, Issue:5

    Topics: Age Factors; Caffeine; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reference Values; Sequence Deletion; Smoking; Theophylline; Turkey

2009
[A comparative study of the effects of Acanthopanacis senticosi injection, theophylline and caffeine on human sperm mobility in vitro].
    Zhonghua nan ke xue = National journal of andrology, 2009, Volume: 15, Issue:3

    Topics: Caffeine; Drugs, Chinese Herbal; Eleutherococcus; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline

2009
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:7

    Topics: Adolescent; Adult; Caffeine; Cardiovascular Diseases; Cytochrome P-450 CYP1A2; Enzyme Activation; Humans; Male; Phenanthrenes; Theophylline; Time Factors

2009
Nano- and macro-geometrical structural change of caffeine and theophylline anhydrate tablets during hydration process by using X-ray computed tomography.
    Colloids and surfaces. B, Biointerfaces, 2009, Oct-15, Volume: 73, Issue:2

    Topics: Caffeine; Compressive Strength; Humidity; Kinetics; Nanostructures; Powders; Pressure; Tablets; Theophylline; Time Factors; Tomography, X-Ray Computed; Water; X-Ray Diffraction

2009
Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.
    Journal of Alzheimer's disease : JAD, 2009, Volume: 17, Issue:3

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Caffeine; Central Nervous System Stimulants; Cognition; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Maze Learning; Mice; Mice, Transgenic; Microdialysis; Phosphodiesterase Inhibitors; Plasma; Presenilin-1; Theophylline; Time Factors

2009
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles

2009
Regulation of cerebrospinal fluid production by caffeine consumption.
    BMC neuroscience, 2009, Sep-03, Volume: 10

    Topics: Animals; Blotting, Western; Caffeine; Cerebral Ventricles; Cerebrospinal Fluid; Cerebrovascular Circulation; Choroid Plexus; Immunohistochemistry; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium-Potassium-Exchanging ATPase; Theophylline

2009
The interaction of lysozyme with caffeine, theophylline and theobromine in solution.
    Molecular biology reports, 2010, Volume: 37, Issue:7

    Topics: Animals; Binding Sites; Caffeine; Chickens; Energy Transfer; Kinetics; Muramidase; Protein Conformation; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Theobromine; Theophylline

2010
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes.
    BioFactors (Oxford, England), 2008, Volume: 34, Issue:4

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines

2008
Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009, Volume: 92, Issue:12

    Topics: beta-Thalassemia; Caffeine; Case-Control Studies; Child; Confidence Intervals; Cytochrome P-450 CYP1A2; Female; Ferritins; Glutathione; Hemoglobin E; Humans; Lipid Peroxides; Liver; Male; Multivariate Analysis; Oxidative Stress; Sex Factors; Thailand; Theophylline; Transaminases

2009
[Rapid determination of theophylline, theobromine and caffeine in dietary supplements containing guarana by ultra-performance liquid chromatography].
    Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 2009, Volume: 50, Issue:6

    Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dietary Supplements; Mass Spectrometry; Paullinia; Theobromine; Theophylline

2009
Zirconia based monoliths used in hydrophilic-interaction chromatography for original selectivity of xanthines.
    Journal of chromatography. A, 2010, Feb-26, Volume: 1217, Issue:9

    Topics: Caffeine; Chromatography, Liquid; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Osmolar Concentration; Silicon Dioxide; Theophylline; Water; Xanthines; Zirconium

2010
Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease.
    Neuroscience, 2010, May-05, Volume: 167, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caffeine; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease, Secondary; Theophylline; Time Factors

2010
Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.
    Acta physiologica (Oxford, England), 2010, Volume: 200, Issue:1

    Topics: Animals; Caffeine; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Glucose Transporter Type 4; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Male; Muscle Contraction; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Theophylline; Threonine; Time Factors

2010
The lipotropic activity of caffeine, theobromine and theophylline.
    Archives of biochemistry, 1947, Volume: 15, Issue:3

    Topics: Caffeine; Lipotropic Agents; Theobromine; Theophylline

1947
Infrared vibrational spectra as a structural probe of gaseous ions formed by caffeine and theophylline.
    Physical chemistry chemical physics : PCCP, 2010, Apr-14, Volume: 12, Issue:14

    Topics: Caffeine; Gases; Molecular Probes; Molecular Structure; Spectrophotometry, Infrared; Theophylline

2010
Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
    Journal of chromatography. A, 2010, May-21, Volume: 1217, Issue:21

    Topics: Acetonitriles; Beverages; Caffeine; Capillary Electrochromatography; Electroosmosis; Food Analysis; Hydrogen-Ion Concentration; Inorganic Chemicals; Linear Models; Microscopy, Electron, Scanning; Organic Chemicals; Phase Transition; Phosphates; Reproducibility of Results; Sensitivity and Specificity; Silicon Dioxide; Sulfonic Acids; Theophylline

2010
Rapid determination of methylxanthines in real samples by high-performance liquid chromatography using the new FastGradient narrow-bore monolithic column.
    Talanta, 2010, Jun-15, Volume: 81, Issue:4-5

    Topics: Beverages; Caffeine; Carbonated Beverages; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Coffee; Food Analysis; Food Contamination; Limit of Detection; Pharmaceutical Preparations; Reproducibility of Results; Tablets; Tea; Theobromine; Theophylline; Water; Xanthines

2010
Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade.
    Respiratory physiology & neurobiology, 2010, Jul-31, Volume: 172, Issue:3

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Caffeine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; In Vitro Techniques; Interneurons; Nerve Net; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Respiratory Insufficiency; Respiratory Physiological Phenomena; Rolipram; Theophylline; Xanthines

2010
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.
    Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:7

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatic Artery; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Portal Vein; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Vascular Resistance; Vasodilation; Vasodilator Agents

2010
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation.
    Biomedical chromatography : BMC, 2011, Volume: 25, Issue:4

    Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theophylline; Uric Acid

2011
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
    Sleep, 2010, Volume: 33, Issue:7

    Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Modafinil; Motor Activity; Narcolepsy; Neuropeptides; Nuclear Proteins; Orexins; Sleep; Theophylline; Transcription Factors

2010
Effect of core size and excipients on the lag time and drug release from a pulsatile drug delivery system.
    Drug development and industrial pharmacy, 2011, Volume: 37, Issue:1

    Topics: Caffeine; Cellulose; Chemistry, Pharmaceutical; Dosage Forms; Drug Carriers; Drug Delivery Systems; Excipients; Hydrophobic and Hydrophilic Interactions; Lactose; Particle Size; Polymers; Solubility; Tablets; Tablets, Enteric-Coated; Theophylline

2011
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
    Biomedical chromatography : BMC, 2011, Volume: 25, Issue:4

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enoxacin; Humans; Male; Norfloxacin; Reproducibility of Results; Sensitivity and Specificity; Theophylline

2011
Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:8

    Topics: Administration, Oral; Animals; Area Under Curve; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochromes; Drugs, Chinese Herbal; Enzyme Inhibitors; Half-Life; Humans; Injections, Intraperitoneal; Liver; Male; Metabolic Clearance Rate; Microsomes, Liver; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Substrate Specificity; Theophylline

2010
Transmission electron microscopy of pharmaceutical materials.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:9

    Topics: Acetaminophen; Caffeine; Crystallization; Microscopy, Electron, Transmission; Oxalic Acid; Pharmaceutical Preparations; Ranitidine; Theophylline

2010
Disposition kinetics of caffeine and paraxanthine in Nile tilapia (Oreochromis niloticus): characterization of the main metabolites.
    Archives of environmental contamination and toxicology, 2011, Volume: 60, Issue:4

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cichlids; Male; Theophylline; Tissue Distribution; Water Pollutants, Chemical

2011
Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:17-18

    Topics: Acridine Orange; Antineoplastic Agents; Biophysical Phenomena; Caffeine; Carcinogens; Chlorophyll; Chlorophyllides; Diet; DNA; Humans; Male; Mutagens; Neoplasms; Theobromine; Theophylline; Xanthines

2010
Pharmacokinetics and metabolism of natural methylxanthines in animal and man.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Animals; Caffeine; Female; Humans; Male; Metabolic Networks and Pathways; Theobromine; Theophylline; Tissue Distribution; Xanthines

2011
Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.
    Microbiology (Reading, England), 2011, Volume: 157, Issue:Pt 2

    Topics: Amino Acid Sequence; Bacterial Proteins; Caffeine; Carbon; Formaldehyde; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Nitrogen; Pseudomonas putida; Sequence Alignment; Substrate Specificity; Theobromine; Theophylline; Xanthines

2011
Effect of caffeine and theophylline on striated muscle work curves.
    The Biological review of the City College, 1946, Volume: 8

    Topics: Caffeine; Humans; Muscle, Skeletal; Muscle, Striated; Muscles; Theophylline; Work

1946
Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines.
    Bioorganic chemistry, 2011, Volume: 39, Issue:1

    Topics: Amines; Caffeine; Calorimetry; Carcinogens; Heterocyclic Compounds; Mutagenicity Tests; Pentoxifylline; Salmonella typhimurium; Spectrum Analysis; Theophylline; Vibrio; Xanthines

2011
Ultrasonic quantification using smart hydrogel sensors.
    Talanta, 2011, Feb-15, Volume: 83, Issue:5

    Topics: Biosensing Techniques; Caffeine; Chemistry Techniques, Analytical; Hydrogel, Polyethylene Glycol Dimethacrylate; Molecular Imprinting; Theophylline; Time Factors; Ultrasonics

2011
Inkjet printing of drug substances and use of porous substrates-towards individualized dosing.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:8

    Topics: Acetaminophen; Administration, Oral; Caffeine; Chromatography, Liquid; Dosage Forms; Mass Spectrometry; Paper; Pharmaceutical Preparations; Porosity; Precision Medicine; Printing; Solutions; Technology, Pharmaceutical; Theophylline

2011
Caffeine and insulin resistance in pregnancy.
    American journal of perinatology, 2011, Volume: 28, Issue:7

    Topics: Birth Weight; Caffeine; Female; Homeostasis; Humans; Infant, Newborn; Insulin Resistance; Male; Pregnancy; Theophylline

2011
Effect of source variation on drug release from HPMC tablets: linear regression modeling for prediction of drug release.
    International journal of pharmaceutics, 2011, Jun-15, Volume: 411, Issue:1-2

    Topics: Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Compressive Strength; Drug Compounding; Drug Design; Drug Industry; Excipients; Forecasting; Hypromellose Derivatives; Linear Models; Methylcellulose; Models, Chemical; Molecular Weight; Pharmaceutical Preparations; Solubility; Tablets; Theobromine; Theophylline; Viscosity

2011
Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 25, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Caffeine; Coffee; Cognition Disorders; Cytokines; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Humans; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuropsychological Tests; Peptide Fragments; Phosphodiesterase Inhibitors; Presenilin-1; Theophylline; Time Factors

2011
Controlled fabrication of theophylline imprinted polymers on multiwalled carbon nanotubes via atom transfer radical polymerization.
    Journal of nanoscience and nanotechnology, 2011, Volume: 11, Issue:2

    Topics: Adsorption; Caffeine; Microscopy, Electron, Transmission; Molecular Imprinting; Nanotechnology; Nanotubes, Carbon; Polymers; Spectroscopy, Fourier Transform Infrared; Theophylline

2011
Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
    Archives of pharmacal research, 2011, Volume: 34, Issue:1

    Topics: Administration, Oral; Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Induction; Indole Alkaloids; Quinazolines; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Vasodilator Agents

2011
Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:7

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Female; Goats; Liver; Oxidation-Reduction; Reference Standards; Theobromine; Theophylline

2011
Clinical and physiological correlates of caffeine and caffeine metabolites in primary insomnia.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Apr-15, Volume: 7, Issue:2

    Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Male; Neuropsychological Tests; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Theophylline

2011
Low- and high-frequency Raman investigations on caffeine: polymorphism, disorder and phase transformation.
    The journal of physical chemistry. B, 2011, May-19, Volume: 115, Issue:19

    Topics: Caffeine; Crystallization; Kinetics; Phase Transition; Spectrum Analysis, Raman; Temperature; Theophylline

2011
Combined effects of THC and caffeine on working memory in rats.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Dronabinol; Drug Synergism; Male; Memory, Short-Term; Rats; Rats, Long-Evans; Receptor, Adenosine A1; Theophylline

2012
Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine.
    Pakistan journal of pharmaceutical sciences, 2011, Volume: 24, Issue:3

    Topics: Animals; Caffeine; Drug Interactions; Eating; Motor Activity; Piperazines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Theophylline

2011
Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers.
    Chirality, 2011, Volume: 23 Suppl 1

    Topics: Caffeine; Chemistry; Chromatography; Chromatography, Supercritical Fluid; Hydrogen Bonding; Methanol; Pharmaceutical Preparations; Pressure; Solubility; Solvents; Stereoisomerism; Temperature; Theophylline

2011
Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:3

    Topics: Animals; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Activation; Enzyme Inhibitors; Ephedra; Glycyrrhiza; Liver; Male; Random Allocation; Rats; Rats, Wistar; Tablets; Theophylline; Time Factors; Water

2012
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
    Clinical pharmacokinetics, 2011, Dec-01, Volume: 50, Issue:12

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Computer Simulation; Cyclosporine; Female; Gastrointestinal Tract; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Obesity, Morbid; Pharmacokinetics; Phenytoin; Regional Blood Flow; Theophylline; Young Adult

2011
Caffeine as an indicator for the quantification of untreated wastewater in karst systems.
    Water research, 2012, Feb-01, Volume: 46, Issue:2

    Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Environmental Monitoring; Germany; Groundwater; Seasons; Sewage; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Movements; Water Pollutants, Chemical

2012
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
    Journal of mass spectrometry : JMS, 2011, Volume: 46, Issue:11

    Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Water Pollutants, Chemical

2011
Diffusion of small molecules in a chitosan/water gel determined by proton localized NMR spectroscopy.
    Journal of colloid and interface science, 2012, Feb-15, Volume: 368, Issue:1

    Topics: Caffeine; Caprolactam; Chitosan; Diffusion; Gels; Magnetic Resonance Spectroscopy; Protons; Theophylline; Water

2012
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
    Neurotoxicology, 2012, Volume: 33, Issue:1

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol

2012
A general strategy for performing temperature-programming in high performance liquid chromatography--further improvements in the accuracy of retention time predictions of segmented temperature gradients.
    Journal of chromatography. A, 2012, Jan-27, Volume: 1222

    Topics: Aspartame; Caffeine; Chromatography, High Pressure Liquid; Food Additives; Linear Models; Models, Chemical; Reproducibility of Results; Rutin; Temperature; Theobromine; Theophylline

2012
New specific marker of cytochrome P450 1A2 activity.
    Bulletin of experimental biology and medicine, 2011, Volume: 150, Issue:6

    Topics: Algorithms; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Humans; Models, Theoretical; Phenotype; Theophylline

2011
Development of a chromatographic low pressure flow injection system: application to the analysis of methylxanthines in coffee.
    Analytica chimica acta, 2012, Feb-17, Volume: 715

    Topics: Beverages; Caffeine; Chromatography, Liquid; Coffee; Flow Injection Analysis; Food Analysis; Limit of Detection; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines

2012
Online coupling of digital microfluidic devices with mass spectrometry detection using an eductor with electrospray ionization.
    Analytical chemistry, 2012, Mar-20, Volume: 84, Issue:6

    Topics: Analysis of Variance; Caffeine; Equipment Design; Microfluidic Analytical Techniques; Spectrometry, Mass, Electrospray Ionization; Theophylline

2012
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, May-01, Volume: 895-896

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Stability; Humans; Imidazoles; Linear Models; Liquid-Liquid Extraction; Losartan; Omeprazole; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles; Theophylline

2012
Changes in CYP1A2 activity in humans after 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) administration using caffeine as a probe drug.
    Drug metabolism and pharmacokinetics, 2012, Volume: 27, Issue:6

    Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Female; Half-Life; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Sex Factors; Theophylline

2012
Caffeine relaxes smooth muscle through actin depolymerization.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Aug-15, Volume: 303, Issue:4

    Topics: Actins; Animals; Biopolymers; Caffeine; Cattle; Enzyme Assays; Humans; In Vitro Techniques; Indoles; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Kinase; Permeability; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Polymerization; Potassium Chloride; Theophylline

2012
Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Analysis of Variance; Blotting, Western; Caffeine; Colforsin; Cyclic AMP; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Humans; In Vitro Techniques; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Theophylline; Trophoblasts

2012
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
    Pharmaceutical research, 2013, Volume: 30, Issue:1

    Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction

2013
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
    Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:4

    Topics: Animals; Behavior, Animal; Caffeine; Carbamazepine; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Heart Rate; Lithium Chloride; Motor Activity; Pentobarbital; Psychotropic Drugs; Theophylline; Toxicity Tests; Valproic Acid; Water Pollutants, Chemical; Zebrafish

2012
Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:4

    Topics: Adolescent; Asian People; Caffeine; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Genotype; Haplotypes; Humans; Male; Polymorphism, Single Nucleotide; Theophylline; Young Adult

2013
High-throughput 96-well solvent mediated sonic blending synthesis and on-plate solid/solution stability characterization of pharmaceutical cocrystals.
    International journal of pharmaceutics, 2013, Jan-30, Volume: 441, Issue:1-2

    Topics: Benzothiazoles; Caffeine; Crystallization; Drug Stability; High-Throughput Screening Assays; Oxalic Acid; Pyrimidines; Solubility; Solvents; Theophylline; X-Ray Diffraction

2013
Spectral analysis of naturally occurring methylxanthines (theophylline, theobromine and caffeine) binding with DNA.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Caffeine; DNA; Spectroscopy, Fourier Transform Infrared; Theobromine; Theophylline

2012
Direct coupling of packed column supercritical fluid chromatography to continuous corona discharge ion mobility spectrometry.
    Journal of chromatography. A, 2013, Jan-11, Volume: 1272

    Topics: Caffeine; Carbon Dioxide; Chromatography, Supercritical Fluid; Ions; Medroxyprogesterone; Rheology; Spectrum Analysis; Testosterone; Theophylline

2013
Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Neuropharmacology, 2013, Volume: 67

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Humans; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Theophylline

2013
Comparative study of the interactions between ovalbumin and three alkaloids by spectrofluorimetry.
    Molecular biology reports, 2013, Volume: 40, Issue:4

    Topics: Binding Sites; Caffeine; Dyphylline; Fluorescence; Hydrogen Bonding; Molecular Structure; Ovalbumin; Protein Binding; Spectrometry, Fluorescence; Theophylline; Thermodynamics

2013
Diurnal variation in CYP1A2 enzyme activity in South Asians and Europeans.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:2

    Topics: Adult; Asian People; Caffeine; Circadian Rhythm; Cytochrome P-450 CYP1A2; Female; Humans; Male; Pharmaceutical Preparations; Saliva; Theophylline; White People; Young Adult

2013
Spectroscopic investigations and hydrogen bond interactions of 8-aza analogues of xanthine, theophylline and caffeine: a theoretical study.
    Journal of molecular modeling, 2013, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Antiviral Agents; Aza Compounds; Caffeine; Gases; Hydrogen Bonding; Kinetics; Models, Chemical; Quantum Theory; Solutions; Spectrum Analysis; Stereoisomerism; Theophylline; Thermodynamics; Water; Xanthines

2013
Caffeine has greater potency and efficacy than theophylline to reverse the motor impairment caused by chronic but not acute interruption of striatal dopaminergic transmission in rats.
    Neuropharmacology, 2013, Volume: 70

    Topics: Animals; Caffeine; Catalepsy; Corpus Striatum; Dopaminergic Neurons; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Skills; Oxidopamine; Parkinsonian Disorders; Rats; Theophylline

2013
Guarana powder polysaccharides: characterisation and evaluation of the antioxidant activity of a pectic fraction.
    Food chemistry, 2012, Oct-15, Volume: 134, Issue:4

    Topics: Antioxidants; Caffeine; Paullinia; Pectins; Plant Extracts; Seeds; Theobromine; Theophylline

2012
Computational design and biosensor applications of small molecule-sensing allosteric ribozymes.
    Biomacromolecules, 2013, Apr-08, Volume: 14, Issue:4

    Topics: Allosteric Site; Biosensing Techniques; Caffeine; Genetic Engineering; Nucleic Acid Conformation; RNA, Catalytic; Theophylline

2013
Comparative study of the binding of pepsin to four alkaloids by spectrofluorimetry.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Volume: 108

    Topics: Absorption; Alkaloids; Aminophylline; Caffeine; Dyphylline; Energy Transfer; Hydrogen-Ion Concentration; Kinetics; Light; Pepsin A; Protein Binding; Protein Conformation; Scattering, Radiation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Theophylline

2013
Morpho-physiological heterogeneity of cells within two rat prostate carcinoma cell lines AT-2 and MAT-LyLu differing in the degree of malignancy observed by cell cloning and the effects of caffeine, theophylline and papaverine upon a proportion of the clo
    Oncology reports, 2013, Volume: 29, Issue:5

    Topics: Animals; Caffeine; Cell Line, Tumor; Cell Movement; Clone Cells; Connexin 43; Male; Neoplasm Invasiveness; Papaverine; Prostatic Neoplasms; Rats; Snail Family Transcription Factors; Theophylline; Transcription Factors

2013
Simultaneous in vivo phenotyping of CYP enzymes.
    Methods in molecular biology (Clifton, N.J.), 2013, Volume: 987

    Topics: Caffeine; Cytochrome P-450 Enzyme System; Humans; Liquid-Liquid Extraction; Phenotype; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Time Factors

2013
A piezoelectric drop-on-demand generator for accurate samples in capillary electrophoresis.
    Talanta, 2013, Mar-30, Volume: 107

    Topics: Bronchodilator Agents; Caffeine; Electrophoresis, Microchip; Equipment Design; Limit of Detection; Sample Size; Theobromine; Theophylline

2013
Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.
    Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:12

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Haplorhini; Humans; Hydroxylation; Liver; Metabolic Networks and Pathways; Methylation; Microsomes, Liver; Molecular Docking Simulation; Oxidation-Reduction; Recombinant Proteins; Theophylline

2013
Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
    Food chemistry, 2013, Dec-01, Volume: 141, Issue:3

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Theobromine; Theophylline

2013
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
    Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:6

    Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment

2013
Simultaneous determination of caffeine, theophylline and theobromine in food samples by a kinetic spectrophotometric method.
    Food chemistry, 2013, Dec-15, Volume: 141, Issue:4

    Topics: Beverages; Caffeine; Kinetics; Neural Networks, Computer; Spectrophotometry; Theobromine; Theophylline; Xanthines

2013
A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:11

    Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Humans; Male; Models, Biological; Theophylline; Xanthines; Young Adult

2013
[Evaluation of pharmacokinetic interaction of aphobazole with CYP1A2 drug-substrate in experiments].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:6

    Topics: Administration, Oral; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Benzimidazoles; Biotransformation; Caffeine; Chromatography, Gas; Cytochrome P-450 CYP1A2; Cytochromes; Drug Administration Schedule; Drug Interactions; Male; Morpholines; Rats; Theobromine; Theophylline

2013
UHPLC determination of catechins for the quality control of green tea.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 88

    Topics: Caffeine; Calibration; Camellia sinensis; Catechin; Chromatography, High Pressure Liquid; Electrochemistry; Geography; Kinetics; Mass Spectrometry; Micelles; Plant Extracts; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tea; Theobromine; Theophylline

2014
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons.
    Neuroscience, 2013, Volume: 255

    Topics: Animals; Caffeine; Inhalation; Interneurons; Motor Neurons; Neural Pathways; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Respiratory Center; Seizures; Theophylline; Xanthines

2013
Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: which measure of variability should be used?
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:3

    Topics: Adult; Area Under Curve; Biomedical Research; Caffeine; Child; Child, Preschool; Female; Humans; Ibuprofen; Infant; Infant, Newborn; Itraconazole; Male; Midazolam; Models, Biological; Pharmacokinetics; Sample Size; Theophylline

2014
Xanthine derivatives quantification in serum by capillary zone electrophoresis.
    Journal of chromatographic science, 2014, Volume: 52, Issue:9

    Topics: Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Reproducibility of Results; Sensitivity and Specificity; Theophylline; Xanthines

2014
Digitally enhanced thin layer chromatography: further development and some applications in isotopic chemistry.
    Journal of labelled compounds & radiopharmaceuticals, 2013, Volume: 56, Issue:11

    Topics: Anthraquinones; Caffeine; Carotenoids; Chromatography, Thin Layer; Image Processing, Computer-Assisted; Isotope Labeling; Lepidium sativum; Sensitivity and Specificity; Theophylline; Tritium

2013
Caffeine accelerates recovery from general anesthesia.
    Journal of neurophysiology, 2014, Volume: 111, Issue:6

    Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous; Animals; Caffeine; Central Nervous System Stimulants; Colforsin; Isoflurane; Neurons; PC12 Cells; Propofol; Rats; Theophylline

2014
An investigation of the causes of cocrystal dissociation at high humidity.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:9

    Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Humidity; Pharmaceutical Preparations; Solubility; Theophylline; Water

2014
A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data.
    Clinical pharmacokinetics, 2014, Volume: 53, Issue:7

    Topics: Adolescent; Adult; Age Factors; Alfentanil; Amides; Caffeine; Child; Child, Preschool; Computer Simulation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Female; Humans; Infant; Infant, Newborn; Liver; Male; Metabolic Clearance Rate; Midazolam; Models, Biological; Ropivacaine; Theophylline

2014
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2

    Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines

2014
Cocrystal dissociation in the presence of water: a general approach for identifying stable cocrystal forms.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:9

    Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Humidity; Oxalic Acid; Pharmaceutical Preparations; Theophylline; Thermodynamics; Water

2014
Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit.
    Phytochemistry, 2014, Volume: 105

    Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Caffeine; Fruit; Methylation; Methyltransferases; Molecular Structure; Paullinia; Plant Leaves; Purines; Seeds; Theobromine; Theophylline; Xanthines

2014
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: studies using medium to high doses in animal models.
    Behavioural brain research, 2014, Aug-15, Volume: 270

    Topics: Affect; Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Purinergic P1 Receptor Antagonists; Theophylline

2014
Facile fabrication of a novel anisotropic gold nanoparticle-chitosan-ionic liquid/graphene modified electrode for the determination of theophylline and caffeine.
    Talanta, 2014, Volume: 127

    Topics: Caffeine; Chitosan; Electrochemical Techniques; Electrodes; Gold; Graphite; Imidazoles; Ionic Liquids; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Theophylline

2014
Why dried blood spots are an ideal tool for CYP1A2 phenotyping.
    Clinical pharmacokinetics, 2014, Volume: 53, Issue:8

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Female; Healthy Volunteers; Humans; Male; Middle Aged; Phenotype; Regression Analysis; Theophylline; Young Adult

2014
Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy.
    Applied spectroscopy, 2014, Volume: 68, Issue:7

    Topics: Caffeine; Carbamazepine; Crystallization; Crystallography; Ethanol; Filtration; Molecular Structure; Pharmaceutical Preparations; Powders; Pyrazoles; Pyridones; Solutions; Solvents; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Theophylline; Vibration; Water

2014
CYP1A2 phenotyping in dried blood spots and microvolumes of whole blood and plasma.
    Bioanalysis, 2014, Volume: 6, Issue:22

    Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Humans; Plasma; Reproducibility of Results; Tandem Mass Spectrometry; Theophylline

2014
Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study.
    Ginekologia polska, 2014, Volume: 85, Issue:7

    Topics: Adult; Caffeine; Female; Fetal Blood; Humans; Infant, Newborn; Logistic Models; Male; Pilot Projects; Poland; Pregnancy; Theophylline; Young Adult

2014
Potassium-based algorithm allows correction for the hematocrit bias in quantitative analysis of caffeine and its major metabolite in dried blood spots.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:26

    Topics: Algorithms; Caffeine; Dried Blood Spot Testing; Hematocrit; Humans; Limit of Detection; Potassium; Theophylline

2014
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: ATP-Binding Cassette Transporters; Caffeine; Carbolines; Cyclic AMP; Cyclic GMP; Dipyridamole; Humans; Imidazoles; Kinetics; Multidrug Resistance-Associated Proteins; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purinones; Sulfones; Tadalafil; Theophylline; Triazines; Vardenafil Dihydrochloride

2014
Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:3

    Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Theobromine; Theophylline

2015
Paraxanthine/Caffeine Concentration Ratios in Hair: An Alternative for Plasma-Based Phenotyping of Cytochrome P450 1A2?
    Clinical pharmacokinetics, 2015, Volume: 54, Issue:7

    Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Hair; Humans; Male; Middle Aged; Phenotype; Theophylline; Young Adult

2015
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
    Epidemiology (Cambridge, Mass.), 2015, Volume: 26, Issue:2

    Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Logistic Models; Male; Maternal Behavior; Obesity; Pregnancy; Pregnancy Trimester, Second; Prenatal Exposure Delayed Effects; Risk Factors; Theophylline

2015
Adenosine signaling in reserpine-induced depression in rats.
    Behavioural brain research, 2015, Jun-01, Volume: 286

    Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Brain; Caffeine; Depressive Disorder; Dose-Response Relationship, Drug; Flavins; Male; Neuropsychological Tests; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reserpine; Swimming; Theophylline

2015
Equilibrium water and solute uptake in silicone hydrogels.
    Acta biomaterialia, 2015, Volume: 18

    Topics: Caffeine; Hydrogels; Hydrophobic and Hydrophilic Interactions; Silicones; Solvents; Theophylline; Water

2015
Genoprotective and hepatoprotective effects of Guarana (Paullinia cupana Mart. var. sorbilis) on CCl4-induced liver damage in rats.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:1

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Carbon Tetrachloride; DNA Damage; Dose-Response Relationship, Drug; Hepatocytes; Liver Diseases; Male; Rats; Rats, Wistar; Silymarin; Theobromine; Theophylline

2016
Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine.
    Dalton transactions (Cambridge, England : 2003), 2015, Apr-28, Volume: 44, Issue:16

    Topics: Antineoplastic Agents; Biological Products; Caffeine; Cell Line, Tumor; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Hydrophobic and Hydrophilic Interactions; Methane; Molecular Conformation; Silver; Theobromine; Theophylline; Xanthine

2015
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake.
    The Journal of nutrition, 2015, Volume: 145, Issue:4

    Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult

2015
Effects of caffeine and its metabolite paraxanthine on intracranial self-stimulation in male rats.
    Experimental and clinical psychopharmacology, 2015, Volume: 23, Issue:2

    Topics: Animals; Caffeine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Self Stimulation; Theophylline

2015
Quantitative on-line concentration for capillary electrophoresis with inkjet sample introduction technique.
    Journal of separation science, 2015, Volume: 38, Issue:15

    Topics: Caffeine; Electrophoresis, Capillary; Limit of Detection; Theobromine; Theophylline

2015
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Jul-15, Volume: 995-996

    Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phenotype; Reproducibility of Results; Saliva; Sensitivity and Specificity; Theophylline

2015
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
    Analytica chimica acta, 2015, Jun-30, Volume: 881

    Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Volunteers; Hematocrit; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline

2015
Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks.
    Neuroscience, 2015, Aug-20, Volume: 301

    Topics: Animals; Animals, Newborn; CA3 Region, Hippocampal; Caffeine; Calcium; Nerve Net; Pyramidal Cells; Rats; Receptors, GABA-A; Receptors, Glycine; Seizures; Theophylline; Xanthines

2015
Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population.
    Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Age Factors; Algorithms; Biomarkers; Biotransformation; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Food, Preserved; Humans; Male; Nigeria; Sex Characteristics; Theophylline; Uric Acid; Young Adult

2015
Simultaneous multiplexed quantification of caffeine and its major metabolites theobromine and paraxanthine using surface-enhanced Raman scattering.
    Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:27

    Topics: Caffeine; Humans; Limit of Detection; Machine Learning; Neural Networks, Computer; Spectrum Analysis, Raman; Surface Properties; Theobromine; Theophylline

2015
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:4

    Topics: Adult; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Risk Assessment; Theophylline; Young Adult

2015
Response Surface Optimization for Decaffeination and Theophylline Production by Fusarium solani.
    Applied biochemistry and biotechnology, 2016, Volume: 178, Issue:1

    Topics: Caffeine; Chromatography, Liquid; Fusarium; Mass Spectrometry; Microscopy, Electron, Scanning; Theophylline

2016
An optimized and validated SPE-LC-MS/MS method for the determination of caffeine and paraxanthine in hair.
    Talanta, 2015, Nov-01, Volume: 144

    Topics: Adult; Analytic Sample Preparation Methods; Caffeine; Chromatography, Liquid; Female; Hair; Humans; Male; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Young Adult

2015
Hypercholesterolemia and Ecto-enzymes of Purinergic System: Effects of Paullinia cupana.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:1

    Topics: Adenosine Deaminase; Animals; Caffeine; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Hypercholesterolemia; Lymphocytes; Male; Paullinia; Plant Preparations; Rats; Rats, Wistar; Theobromine; Theophylline

2016
Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age.
    American journal of epidemiology, 2015, Dec-15, Volume: 182, Issue:12

    Topics: Adult; Caffeine; Child; Child Behavior; Child, Preschool; Coffee; Cognition; Female; Follow-Up Studies; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk Factors; Theophylline; Young Adult

2015
Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy.
    Talanta, 2016, Jan-15, Volume: 147

    Topics: Caffeic Acids; Caffeine; Catechin; Chlorogenic Acid; Coffee; Spectroscopy, Near-Infrared; Theobromine; Theophylline; Waste Products

2016
Degradation of exogenous caffeine by Populus alba and its effects on endogenous caffeine metabolism.
    Environmental science and pollution research international, 2016, Volume: 23, Issue:8

    Topics: Biodegradation, Environmental; Caffeine; Chromatography, High Pressure Liquid; Hydroponics; Plant Leaves; Plant Roots; Plant Stems; Populus; Tandem Mass Spectrometry; Theobromine; Theophylline; Water Pollutants, Chemical

2016
Correction.
    Hypertension (Dallas, Tex. : 1979), 2016, Volume: 67, Issue:2

    Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Theobromine; Theophylline

2016
Stepwise injection potentiometric determination of caffeine in saliva using single-drop microextraction combined with solvent exchange.
    Talanta, 2016, Apr-01, Volume: 150

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Liquid Phase Microextraction; Potentiometry; Saliva; Theobromine; Theophylline

2016
Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
    European journal of immunology, 2016, Volume: 46, Issue:5

    Topics: Caffeine; Cytokines; Gene Expression Regulation; Gene Silencing; Humans; Immunosuppressive Agents; Low Density Lipoprotein Receptor-Related Protein-1; Methotrexate; Mitogens; RNA, Small Interfering; T-Lymphocytes; Theophylline; Thrombospondin 1

2016
Application of a Physiologically Based Pharmacokinetic Model to Study Theophylline Metabolism and Its Interactions With Ciprofloxacin and Caffeine.
    CPT: pharmacometrics & systems pharmacology, 2016, Volume: 5, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Bronchodilator Agents; Caffeine; Ciprofloxacin; Computer Simulation; Dose-Response Relationship, Drug; Drug Dosage Calculations; Drug Interactions; Female; Humans; Male; Middle Aged; Models, Biological; Precision Medicine; Sex Factors; Theophylline

2016
[Coffee lowers in a study blood pressure].
    MMW Fortschritte der Medizin, 2015, Nov-19, Volume: 157, Issue:20

    Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Female; Humans; Male; Theobromine; Theophylline

2015
Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor.
    Materials science & engineering. C, Materials for biological applications, 2016, Aug-01, Volume: 65

    Topics: Caffeine; Carbon; Dielectric Spectroscopy; Electrochemical Techniques; Electrodes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Microscopy, Atomic Force; Molecular Imprinting; Polymers; Theobromine; Theophylline; Tin Compounds

2016
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study.
    The American journal of clinical nutrition, 2016, Volume: 104, Issue:1

    Topics: Adult; Asian People; Caffeine; Coffee; Female; Humans; Menstrual Cycle; Ovulation; Ovulation Inhibition; Racial Groups; Risk Factors; Testosterone; Theophylline; Young Adult

2016
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.
    Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:4

    Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline

2016
Determination of illicit drugs in aqueous environmental samples by online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry.
    Chemosphere, 2016, Volume: 160

    Topics: Caffeine; China; Chromatography, Liquid; Cotinine; Environmental Monitoring; Illicit Drugs; Pseudoephedrine; Reproducibility of Results; Rivers; Solid Phase Extraction; Tandem Mass Spectrometry; Theophylline; Wastewater; Water Pollutants, Chemical

2016
Control of methylxanthines in the competition horse: pharmacokinetic/pharmacodynamic studies on caffeine, theobromine and theophylline for the assessment of irrelevant concentrations.
    Drug testing and analysis, 2017, Volume: 9, Issue:9

    Topics: Animals; Caffeine; Chromatography, Liquid; Horses; Theobromine; Theophylline; Xanthines

2017
Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.
    Human molecular genetics, 2016, 12-15, Volume: 25, Issue:24

    Topics: Antigens, CD; Basic Helix-Loop-Helix Transcription Factors; Caffeine; CD83 Antigen; Coffee; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Genome-Wide Association Study; Humans; Immunoglobulins; Male; Membrane Glycoproteins; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon; Theobromine; Theophylline; White People

2016
Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain.
    Physiology & behavior, 2017, 01-01, Volume: 168

    Topics: Acetylcholinesterase; Animals; Blood Glucose; Brain; Caffeine; Cholesterol; Hyperlipidemias; Male; Maze Learning; Paullinia; Plant Extracts; Poloxamer; Rats; Rats, Wistar; Recognition, Psychology; Statistics, Nonparametric; Surface-Active Agents; Theobromine; Theophylline

2017
Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Mar-01, Volume: 99

    Topics: Aminosalicylic Acid; Antitubercular Agents; Caffeine; Crystallization; Crystallography, X-Ray; Drug Stability; Isoniazid; Models, Molecular; Niacinamide; Powder Diffraction; Pyrazinamide; Solubility; Theophylline; X-Ray Diffraction

2017
Time domain NMR as a new process monitoring method for characterization of pharmaceutical hydrates.
    Journal of pharmaceutical and biomedical analysis, 2017, Apr-15, Volume: 137

    Topics: Caffeine; Chemistry, Pharmaceutical; Magnetic Resonance Spectroscopy; Spectrum Analysis, Raman; Theophylline; Water

2017
Sperm motility activation in the critically endangered booroolong frog: the effect of medium osmolality and phosphodiesterase inhibitors.
    Reproduction, fertility, and development, 2017, Volume: 29, Issue:11

    Topics: Animals; Anura; Caffeine; Fertilization in Vitro; Male; Osmolar Concentration; Pentoxifylline; Phosphodiesterase Inhibitors; Semen Analysis; Sperm Motility; Spermatozoa; Theophylline

2017
Structures of Human A
    Structure (London, England : 1993), 2017, 08-01, Volume: 25, Issue:8

    Topics: Binding Sites; Caffeine; HEK293 Cells; Humans; Molecular Docking Simulation; Protein Binding; Receptor, Adenosine A1; Receptor, Adenosine A2A; Substrate Specificity; Theophylline

2017
Saturated phosphatidylcholine as matrix former for oral extended release dosage forms.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Oct-15, Volume: 108

    Topics: Administration, Oral; Caffeine; Chemistry, Pharmaceutical; Diffusion; Drug Delivery Systems; Drug Liberation; Excipients; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Osmolar Concentration; Particle Size; Phosphatidylcholines; Porosity; Solubility; Tablets; Theophylline

2017
Caffeine and paraxanthine in aquatic systems: Global exposure distributions and probabilistic risk assessment.
    The Science of the total environment, 2018, Jan-15, Volume: 612

    Topics: Animals; Aquatic Organisms; Caffeine; Chlorophyta; Daphnia; Fishes; Humans; Risk Assessment; Theophylline; Water Movements; Water Pollutants, Chemical

2018
Mechanistic Insight into Caffeine-Oxalic Cocrystal Dissociation in Formulations: Role of Excipients.
    Molecular pharmaceutics, 2017, 11-06, Volume: 14, Issue:11

    Topics: Caffeine; Crystallization; Drug Compounding; Drug Stability; Excipients; Theophylline; X-Ray Diffraction

2017
Nitrogen-doped carbon nanotubes decorated poly (L-Cysteine) as a novel, ultrasensitive electrochemical sensor for simultaneous determination of theophylline and caffeine.
    Talanta, 2018, Feb-01, Volume: 178

    Topics: Caffeine; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Limit of Detection; Models, Molecular; Molecular Conformation; Nanotubes, Carbon; Nitrogen; Peptides; Theophylline; Time Factors

2018
Chemical profiling of guarana seeds (Paullinia cupana) from different geographical origins using UPLC-QTOF-MS combined with chemometrics.
    Food research international (Ottawa, Ont.), 2017, Volume: 102

    Topics: Biflavonoids; Brazil; Caffeine; Catechin; Chromatography, High Pressure Liquid; Mass Spectrometry; Paullinia; Phenols; Proanthocyanidins; Seeds; Theobromine; Theophylline

2017
Determination of caffeine, theobromine and theophylline in Mate beer and Mate soft drinks by high-performance thin-layer chromatography.
    Journal of chromatography. A, 2018, Jan-19, Volume: 1533

    Topics: Beer; Caffeine; Carbonated Beverages; Chromatography, Thin Layer; Food Analysis; Theobromine; Theophylline

2018
Poly(para-phenyleneethynylene)-Sensor Arrays Discriminate 22 Different Teas.
    ACS sensors, 2018, 02-23, Volume: 3, Issue:2

    Topics: Alkynes; Biosensing Techniques; Caffeine; Camellia sinensis; Ethers; Plant Leaves; Tea; Theobromine; Theophylline

2018
An aptamer nanopore-enabled microsensor for detection of theophylline.
    Biosensors & bioelectronics, 2018, May-15, Volume: 105

    Topics: Animals; Aptamers, Nucleotide; Biosensing Techniques; Bronchodilator Agents; Caffeine; Cattle; Equipment Design; Limit of Detection; Nanopores; Plant Extracts; Theobromine; Theophylline; Vasodilator Agents

2018
Application of HRAM screening and LC-MS/MS confirmation of active pharmaceutical ingredient in "natural" herbal supplements.
    Forensic science international, 2018, Volume: 286

    Topics: Anti-Obesity Agents; Appetite Depressants; Caffeine; Central Nervous System Stimulants; Chromatography, Liquid; Cyclobutanes; Dietary Supplements; Drug Contamination; Humans; Liquid-Liquid Extraction; Mass Spectrometry; Theophylline

2018
Simultaneous determination of theophylline and caffeine on novel [Tetra-(5-chloroquinolin-8-yloxy) phthalocyanato] manganese(III)-Carbon nanotubes composite electrode.
    Talanta, 2018, Jul-01, Volume: 184

    Topics: Caffeine; Cola; Coordination Complexes; Electrochemical Techniques; Electrodes; Manganese; Molecular Structure; Nanotubes, Carbon; Nitriles; Particle Size; Quinolines; Surface Properties; Tea; Theophylline

2018
A new insight into the oxidative mechanism of caffeine and related methylxanthines in aprotic medium: May caffeine be really considered as an antioxidant?
    Biochimica et biophysica acta. General subjects, 2018, Volume: 1862, Issue:8

    Topics: Antioxidants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Humans; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Solvents; Theobromine; Theophylline

2018
Biodegradation of caffeine by whole cells of tea-derived fungi Aspergillus sydowii, Aspergillus niger and optimization for caffeine degradation.
    BMC microbiology, 2018, 06-05, Volume: 18, Issue:1

    Topics: Aspergillus; Aspergillus niger; Biodegradation, Environmental; Caffeine; Fermentation; Substrate Specificity; Tea; Theophylline; Xanthines

2018
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium
    Journal of microbiology and biotechnology, 2018, Jul-28, Volume: 28, Issue:7

    Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines

2018
Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease.
    PloS one, 2018, Volume: 13, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Middle Aged; Parkinson Disease; Pilot Projects; Theophylline

2018
Evaluation of the Capitainer-B Microfluidic Device as a New Hematocrit-Independent Alternative for Dried Blood Spot Collection.
    Analytical chemistry, 2018, 11-06, Volume: 90, Issue:21

    Topics: Caffeine; Calibration; Chromatography, Liquid; Dried Blood Spot Testing; Female; Hematocrit; Humans; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques; Tandem Mass Spectrometry; Theophylline

2018
Guarana (Paullinia cupana Mart.) alters gut microbiota and modulates redox status, partially via caffeine in Wistar rats.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:12

    Topics: Animals; Antioxidants; Caffeine; Dysbiosis; Gastrointestinal Microbiome; Male; Oxidation-Reduction; Oxidative Stress; Paullinia; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Seeds; Theobromine; Theophylline

2018
Theophylline and Caffeine as Alternatives During an Aminophylline Shortage.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:3

    Topics: Aminophylline; Caffeine; Coronary Disease; Drug Utilization; Exercise Test; Female; Humans; Male; Theophylline; Vasodilator Agents

2019
Effect of potassium chloride on the solvation behavior of caffeine, theophylline and theobromine: Volumetric, viscometric, calorimetry and spectroscopic approach.
    Food chemistry, 2018, Nov-15, Volume: 266

    Topics: Caffeine; Calorimetry; Magnetic Resonance Spectroscopy; Potassium Chloride; Spectrophotometry; Temperature; Theobromine; Theophylline; Thermodynamics; Viscosity; Water

2018
Effect of Formulation on the Binding Efficiency and Selectivity of Precipitation Molecularly Imprinted Polymers.
    Molecules (Basel, Switzerland), 2018, Nov-16, Volume: 23, Issue:11

    Topics: Caffeine; Chemical Precipitation; Cross-Linking Reagents; Drug Compounding; Molecular Imprinting; Polymerization; Polymers; Theophylline

2018
A rapid method for the assay of methylxanthines alkaloids: Theobromine, theophylline and caffeine, in cocoa products and drugs by paper spray tandem mass spectrometry.
    Food chemistry, 2019, Apr-25, Volume: 278

    Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Food Analysis; Limit of Detection; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Theobromine; Theophylline

2019
Lamotrigine: Design and synthesis of new multicomponent solid forms.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Mar-01, Volume: 129

    Topics: Caffeine; Calorimetry, Differential Scanning; Crystallization; Crystallography, X-Ray; Lamotrigine; Powder Diffraction; Solubility; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Theophylline; Thermodynamics; X-Ray Diffraction

2019
Prediction of self-assembly of adenosine analogues in solution: a computational approach validated by isothermal titration calorimetry.
    Physical chemistry chemical physics : PCCP, 2019, Feb-20, Volume: 21, Issue:8

    Topics: Adenosine; Caffeine; Calorimetry; Dimerization; Models, Molecular; Molecular Structure; Solvents; Structure-Activity Relationship; Surface Properties; Theophylline; Thermodynamics; Water

2019
Reliability of the Hansen solubility parameters as co-crystal formation prediction tool.
    International journal of pharmaceutics, 2019, Mar-10, Volume: 558

    Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Niacinamide; Piroxicam; Solubility; Theophylline

2019
Effects of hydroalcoholic and enzyme-assisted extraction processes on the recovery of catechins and methylxanthines from crude and waste seeds of guarana (Paullinia cupana).
    Food chemistry, 2019, May-30, Volume: 281

    Topics: Antioxidants; Caffeine; Catechin; Paullinia; Phenol; Plant Extracts; Seeds; Theobromine; Theophylline; Xanthines

2019
Lipotoxicity-associated inflammation is prevented by guarana (
    Drug and chemical toxicology, 2021, Volume: 44, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperlipidemias; Inflammation; Lymphocytes; Male; Rats; Rats, Wistar; Simvastatin; Theobromine; Theophylline

2021
Production and characterization of solid lipid microparticles loaded with guaraná (Paullinia cupana) seed extract.
    Food research international (Ottawa, Ont.), 2019, Volume: 123

    Topics: alpha-Amylases; alpha-Glucosidases; Anti-Obesity Agents; Caffeine; Catechin; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Freeze Drying; Fruit; Lipase; Particle Size; Paullinia; Phenols; Plant Extracts; Seeds; Theobromine; Theophylline

2019
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
    Molecules (Basel, Switzerland), 2019, Aug-07, Volume: 24, Issue:16

    Topics: Caffeine; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theobromine; Theophylline

2019
Challenging the international residue limit concept for feed contaminants in equine doping analytics.
    The Veterinary record, 2019, 08-24, Volume: 185, Issue:8

    Topics: Animals; Caffeine; Doping in Sports; Horses; Theophylline

2019
A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:22

    Topics: Adult; Aged; Alkaloids; Biomarkers; Caffeine; Coffee; Europe; Female; Humans; Male; Metabolomics; Middle Aged; Prospective Studies; Theophylline

2019
Evaluation of the Performance and Hematocrit Independence of the HemaPEN as a Volumetric Dried Blood Spot Collection Device.
    Analytical chemistry, 2019, 11-19, Volume: 91, Issue:22

    Topics: Caffeine; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Female; Humans; Tandem Mass Spectrometry; Theophylline

2019
Protective effect of guarana-loaded liposomes on hemolytic activity.
    Colloids and surfaces. B, Biointerfaces, 2020, Volume: 187

    Topics: Animals; Antioxidants; Caffeine; Drug Compounding; Hemolysis; Liposomes; Particle Size; Protective Agents; Rats; Theobromine; Theophylline

2020
Production of theophylline via aerobic fermentation of pu-erh tea using tea-derived fungi.
    BMC microbiology, 2019, 11-26, Volume: 19, Issue:1

    Topics: Aerobiosis; Caffeine; Fermentation; Fungi; Plant Leaves; Secondary Metabolism; Tea; Temperature; Theophylline

2019
Solvent and temperature effect of accelerated solvent extraction (ASE) coupled with ultra-high-pressure liquid chromatography (UHPLC-PDA) for the determination of methyl xanthines in commercial tea and coffee.
    Food chemistry, 2020, May-01, Volume: 311

    Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Sensitivity and Specificity; Solvents; Tea; Temperature; Theobromine; Theophylline; Xanthines

2020
Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile.
    Molecules (Basel, Switzerland), 2020, Feb-05, Volume: 25, Issue:3

    Topics: alpha-Glucosidases; Brazil; Caffeine; Diabetes Mellitus, Type 2; Dietary Supplements; Glycoside Hydrolase Inhibitors; Humans; Medicine, Traditional; Paullinia; Phytochemicals; Plant Extracts; Polyphenols; Proanthocyanidins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Theobromine; Theophylline

2020
In vivo solid-phase microextraction swab sampling of environmental pollutants and drugs in human body for nano-electrospray ionization mass spectrometry analysis.
    Analytica chimica acta, 2020, Aug-08, Volume: 1124

    Topics: Caffeine; Environmental Pollutants; Human Body; Humans; Imidazoles; Mouth; Nanotechnology; Nicotine; Skin; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization; Theobromine; Theophylline

2020
Exploring hand-portable nano-liquid chromatography for in place water analysis: Determination of trimethylxanthines as a use case.
    The Science of the total environment, 2020, Dec-10, Volume: 747

    Topics: Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Limit of Detection; Solid Phase Microextraction; Theophylline; Water Pollutants, Chemical

2020
Chemical implications and time reduction of on-farm cocoa fermentation by Saccharomyces cerevisiae and Pichia kudriavzevii.
    Food chemistry, 2021, Feb-15, Volume: 338

    Topics: Amines; Cacao; Caffeine; Catechin; Chocolate; Farms; Fermentation; Food Microbiology; Hydrogen-Ion Concentration; Phenols; Pichia; Saccharomyces cerevisiae; Temperature; Theobromine; Theophylline; Time Factors

2021
Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study.
    Nutrients, 2020, Sep-13, Volume: 12, Issue:9

    Topics: Adult; Aged; Caffeine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nutrition Surveys; Theobromine; Theophylline; Urination

2020
Detection of caffeine intake by means of EC-SERS spectroscopy of human saliva.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Feb-05, Volume: 246

    Topics: Caffeine; Humans; Saliva; Spectrum Analysis; Theophylline

2021
Caffeine inhibits Notum activity by binding at the catalytic pocket.
    Communications biology, 2020, 10-08, Volume: 3, Issue:1

    Topics: Caffeine; Catalytic Domain; Dose-Response Relationship, Drug; Esterases; HEK293 Cells; Humans; Protein Binding; Protein Structure, Tertiary; Theophylline

2020
Simultaneous determination of theobromine, theophylline, and caffeine using a modified electrode with petal-like MnO
    Talanta, 2021, Jan-15, Volume: 222

    Topics: Caffeine; Electrodes; Manganese Compounds; Nanostructures; Oxides; Theobromine; Theophylline

2021
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.
    International journal of molecular sciences, 2020, Nov-27, Volume: 21, Issue:23

    Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans; Neuroblastoma; Pentoxifylline; Principal Component Analysis; Theobromine; Theophylline; Transcription, Genetic; Xanthines

2020
Electrochemical sensing platform based on covalent organic framework materials and gold nanoparticles for high sensitivity determination of theophylline and caffeine.
    Mikrochimica acta, 2021, 02-15, Volume: 188, Issue:3

    Topics: Acetaminophen; Caffeine; Capsules; Drug Contamination; Electrochemical Techniques; Electrodes; Gold; Limit of Detection; Metal Nanoparticles; Metal-Organic Frameworks; Reproducibility of Results; Tea; Theophylline

2021
Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.
    JAMA network open, 2021, 03-01, Volume: 4, Issue:3

    Topics: Adult; Anthropometry; Biomarkers; Birth Weight; Caffeine; Female; Fetal Development; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Pregnancy; Retrospective Studies; Theophylline

2021
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
    Regulatory toxicology and pharmacology : RTP, 2021, Volume: 123

    Topics: Animals; Caffeine; Cosmetics; Eating; Humans; Risk Assessment; Theobromine; Theophylline; Toxicity Tests; Xanthines

2021
Methylxanthines in COPD: yes to caffeine, no to theophylline.
    The European respiratory journal, 2021, Volume: 57, Issue:6

    Topics: Caffeine; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline; Xanthines

2021
The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS.
    Talanta, 2021, Nov-01, Volume: 234

    Topics: Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Theophylline

2021
[Determination of Caffeine, Theobromine, and Theophylline in Chocolate Using LC-MS].
    Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 2021, Volume: 62, Issue:4

    Topics: Caffeine; Chocolate; Chromatography, Liquid; Reproducibility of Results; Tandem Mass Spectrometry; Theobromine; Theophylline

2021
Complexation of caffeine and theophylline with epigallocatechin gallate in aqueous solution: Nuclear magnetic resonance, molecular docking and thermodynamics studies.
    Food research international (Ottawa, Ont.), 2021, Volume: 148

    Topics: Caffeine; Catechin; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Theophylline; Thermodynamics

2021
Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies.
    Mayo Clinic proceedings, 2021, Volume: 96, Issue:12

    Topics: Adult; Belgium; Caffeine; Cholesterol; Cholesterol, HDL; Chromatography, High Pressure Liquid; Female; Humans; Lipids; Male; Middle Aged; Switzerland; Tandem Mass Spectrometry; Theobromine; Theophylline; Triglycerides; Xanthines

2021
Dual genetic selection of the theophylline riboswitch with altered aptamer specificity for caffeine.
    Biochemical and biophysical research communications, 2021, 11-19, Volume: 579

    Topics: beta-Galactosidase; Caffeine; Chloramphenicol; Drug Resistance; Escherichia coli; Gene Expression Regulation; Green Fluorescent Proteins; Microbial Sensitivity Tests; Oligonucleotides; Plasmids; Recombinant Fusion Proteins; Riboswitch; Selection, Genetic; Theophylline

2021
Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS.
    Journal of separation science, 2021, Volume: 44, Issue:23

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Theobromine; Theophylline; Uric Acid

2021
Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2022, Volume: 59, Issue:11

    Topics: Adult; Asthma; Bronchodilator Agents; Caffeine; Coffee; Cross-Sectional Studies; Humans; Lung; Nutrition Surveys; Theobromine; Theophylline

2022
Finger sweat analysis enables short interval metabolic biomonitoring in humans.
    Nature communications, 2021, 10-13, Volume: 12, Issue:1

    Topics: Adult; Biological Monitoring; Biotransformation; Caffeine; Chlorogenic Acid; Chromatography, Liquid; Coffee; Female; Fingers; Humans; Male; Metabolomics; Middle Aged; Principal Component Analysis; Sweat; Tandem Mass Spectrometry; Theobromine; Theophylline

2021
Maternal caffeine intake and DNA methylation in newborn cord blood.
    The American journal of clinical nutrition, 2022, 02-09, Volume: 115, Issue:2

    Topics: Adult; Caffeine; DNA Methylation; Epigenesis, Genetic; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Male; Maternal Exposure; Middle Aged; Pregnancy; Theobromine; Theophylline

2022
Caffeine and Paraxanthine as Tracers of Anthropogenic Wastewater in Coastal Lagoons in Yucatan, Mexico.
    Bulletin of environmental contamination and toxicology, 2022, Volume: 108, Issue:2

    Topics: Caffeine; Environmental Monitoring; Groundwater; Mexico; Theophylline; Wastewater; Water Pollutants, Chemical

2022
Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues.
    Analytical chemistry, 2022, 02-22, Volume: 94, Issue:7

    Topics: Beverages; Caffeine; Calorimetry; Humans; Oligonucleotides; Theobromine; Theophylline

2022
The analysis of methylxanthine fractions obtained from Camellia sinensis cultivated in Turkey and effects on the in vitro inhibition of CYP2D6 enzyme.
    Biotechnology and applied biochemistry, 2023, Volume: 70, Issue:1

    Topics: Caffeine; Camellia sinensis; Cytochrome P-450 CYP2D6; Tea; Theobromine; Theophylline; Turkey

2023
Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells.
    International journal of molecular sciences, 2022, Feb-18, Volume: 23, Issue:4

    Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuroblastoma; Neurodegenerative Diseases; Pentoxifylline; Theobromine; Theophylline; Triglycerides; Xanthines

2022
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.
    Clinical and translational science, 2022, Volume: 15, Issue:6

    Topics: Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Humans; Melatonin; Theophylline

2022
To what extent do bond length and angle govern the
    Solid state nuclear magnetic resonance, 2022, Volume: 119

    Topics: Caffeine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Theophylline

2022
Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Animals; Caffeine; Dogs; Harmine; Male; Metabolic Diseases; Metabolome; Obesity; Theophylline

2022
Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk.
    Nutrients, 2022, May-25, Volume: 14, Issue:11

    Topics: Caffeine; Chromatography, Liquid; Female; Humans; Milk, Human; Tandem Mass Spectrometry; Theobromine; Theophylline

2022
Simultaneous quantification of caffeine and its main metabolites by gas chromatography mass spectrometry in horse urine.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:10

    Topics: Animals; Caffeine; Gas Chromatography-Mass Spectrometry; Horses; Solid Phase Extraction; Theobromine; Theophylline

2022
Therapeutic drug monitoring of caffeine and its primary metabolites in plasma using LC-ESI-MS/MS for apnea of prematurity treatment: Evaluation of ultrapure water as a surrogate matrix.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:11

    Topics: Animals; Apnea; Caffeine; Drug Monitoring; Humans; Infant, Newborn; Infant, Premature; Rats; Tandem Mass Spectrometry; Theobromine; Theophylline; Water

2022
Interactions between Caffeine, Theophylline and Derivatives with Gold Nanoparticles and Implications for Aptamer-Based Label-Free Colorimetric Detection.
    ChemPlusChem, 2022, Volume: 87, Issue:11

    Topics: Caffeine; Colorimetry; Gold; Metal Nanoparticles; Theophylline; Xanthines

2022
A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis.
    Journal of pharmacological sciences, 2023, Volume: 151, Issue:1

    Topics: Animals; Caffeine; Cysteine; Glutathione; HEK293 Cells; Humans; Hydrogen Peroxide; Mice; Neuroblastoma; Theophylline; Uric Acid

2023
Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
    Nutrition research (New York, N.Y.), 2023, Volume: 109

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cognition; Nutrition Surveys; Theophylline

2023
Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression.
    International journal of molecular sciences, 2022, Dec-07, Volume: 23, Issue:24

    Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Caffeine; Claudin-2; Doxorubicin; Humans; Lung Neoplasms; NF-E2-Related Factor 2; Theophylline

2022
Association of urinary caffeine and caffeine metabolites with bone mineral density in children and adolescents.
    Medicine, 2022, Dec-09, Volume: 101, Issue:49

    Topics: Adolescent; Adult; Bone Density; Caffeine; Child; Coffee; Cross-Sectional Studies; Female; Humans; Nutrition Surveys; Theophylline; Young Adult

2022
Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients.
    PloS one, 2023, Volume: 18, Issue:3

    Topics: Bronchodilator Agents; Caffeine; Child, Preschool; Diuretics; Dyskinesias; Humans; Phosphodiesterase Inhibitors; Psychomotor Agitation; Theophylline; Vasodilator Agents

2023
Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.
    Pharmacology, biochemistry, and behavior, 2023, Volume: 229

    Topics: Analgesics, Opioid; Animals; Caffeine; Fentanyl; Male; Mice; Naloxone; Narcotic Antagonists; Oxycodone; Respiratory Insufficiency; Theophylline

2023
Cross-Binding of Four Adenosine/ATP Aptamers to Caffeine, Theophylline, and Other Methylxanthines.
    Biochemistry, 2023, 08-01, Volume: 62, Issue:15

    Topics: Adenosine; Adenosine Triphosphate; Aptamers, Nucleotide; Caffeine; Theophylline

2023
Cross-Binding of Adenosine by Aptamers Selected Using Theophylline.
    Chembiochem : a European journal of chemical biology, 2023, Dec-01, Volume: 24, Issue:23

    Topics: Adenosine; Aptamers, Nucleotide; Caffeine; Nucleotide Motifs; Theophylline

2023
Electrochemical Sensing Platform Based on Carbon Dots for the Simultaneous Determination of Theophylline and Caffeine in Tea.
    Sensors (Basel, Switzerland), 2023, Sep-07, Volume: 23, Issue:18

    Topics: Caffeine; Carbon; Chitosan; Reproducibility of Results; Tea; Theophylline

2023
Association between urine caffeine metabolites and bone mineral density: A population-based study.
    Medicine, 2023, Oct-27, Volume: 102, Issue:43

    Topics: Adult; Bone Density; Caffeine; Cross-Sectional Studies; Humans; Nutrition Surveys; Theophylline

2023