caffeine and probenecid

caffeine has been researched along with probenecid in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (16.67)	18.7374
1990's	1 (4.17)	18.2507
2000's	8 (33.33)	29.6817
2010's	11 (45.83)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Haefely, W; Jalfre, M; Ruch-Monachon, MA	1
He, XF; Jin, X; Wang, MZ; Zhang, ZH; Zhou, ZH	1
Bowman, RH; Coulson, R	1
Arbin, A; Edlund, PO	1
Drewe, J; Haefeli, WE; Krähenbühl, S; Vrtic, F; Wenk, M	1
DAVOREN, PR; SUTHERLAND, EW	1
Burhenne, J; Göggelmann, C; Haefeli, WE; Mikus, G; Rengelshausen, J; Riedel, KD; Walter-Sack, I	1
Hanaoka, K; Hosoya, T; Kawamura, M; Udagawa, T	1
Cao, J; Huang, L; Iguchi, N; Riethmacher, D; Xu, J	1

Reviews

1 review(s) available for caffeine and probenecid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for caffeine and probenecid

Article	Year
Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:8 Topics: Adult; Area Under Curve; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Creatinine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Depression, Chemical; Double-Blind Method; Female; Humans; Kidney; Male; Probenecid; Renal Agents; Spectrophotometry, Ultraviolet; Xanthine Oxidase; Xanthines	2007

Article

Year

Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid.

International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:8

Topics: Adult; Area Under Curve; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Creatinine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Depression, Chemical; Double-Blind Method; Female; Humans; Kidney; Male; Probenecid; Renal Agents; Spectrophotometry, Ultraviolet; Xanthine Oxidase; Xanthines

2007

Other Studies

22 other study(ies) available for caffeine and probenecid

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Drugs and PGO waves in the lateral geniculate body of the curarized cat. V. Miscellaneous compounds. Synopsis of the role of central neurotransmitters on PGO wave activity. Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 219, Issue:2 Topics: Amantadine; Analgesics, Opioid; Animals; Caffeine; Convulsants; Electroencephalography; Ethanol; Geniculate Bodies; Glycolates; Histidine; Hydroxybutyrates; Hypnotics and Sedatives; Indoles; Lithium; Mescaline; Methamphetamine; Neurotransmitter Agents; Occipital Lobe; Phentolamine; Phenytoin; Pons; Probenecid; Rabbits; Tranquilizing Agents	1976
[Solid-phase extraction and RP-HPLC screening procedure for diuretics, probenecid, caffeine and pemoline in urine]. Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:11 Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Diuretics; Humans; Pemoline; Probenecid	1992
Excretion and degradation of exogenous adenosine 3',5'-monophosphate by isolated perfused rat kidney. Life sciences, 1974, Feb-01, Volume: 14, Issue:3 Topics: Aminophylline; Animals; Caffeine; Chromatography, Ion Exchange; Creatinine; Cyclic AMP; Glomerular Filtration Rate; Kidney; Kidney Tubules; Male; Perfusion; Probenecid; Rats; Time Factors; Tritium	1974
Determination of theophylline and probenecid in biological material. Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:3 Topics: Animals; Brain Chemistry; Caffeine; Chloroform; Chromatography; Chromatography, Gas; Hydrogen-Ion Concentration; Methods; Probenecid; Solvents; Theobromine; Theophylline; Water	1974
Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug. British journal of clinical pharmacology, 2003, Volume: 55, Issue:2 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Humans; Ibuprofen; Male; Phenotype; Probenecid; Uricosuric Agents	2003
THE EFFECT OF L-EPINEPHRINE AND OTHER AGENTS ON THE SYNTHESIS AND RELEASE OF ADENOSINE 3',5'-PHOSPHATE BY WHOLE PIGEON ERYTHROCYTES. The Journal of biological chemistry, 1963, Volume: 238 Topics: Adenine Nucleotides; Adenosine; Animals; Birds; Caffeine; Columbidae; Epinephrine; Erythrocytes; Isoproterenol; Magnesium; Norepinephrine; Pharmacology; Phosphates; Probenecid; Research; Sympatholytics	1963
Characteristics of spontaneous calcium oscillations in renal tubular epithelial cells. Clinical and experimental nephrology, 2012, Volume: 16, Issue:3 Topics: Animals; Boron Compounds; Caffeine; Calcium; Calcium Signaling; Cell Line; Dogs; Epithelial Cells; Estrenes; Fura-2; Inositol 1,4,5-Trisphosphate; Kidney Tubules; Probenecid; Pyrrolidinones; Ryanodine	2012
Functional characterization of bitter-taste receptors expressed in mammalian testis. Molecular human reproduction, 2013, Volume: 19, Issue:1 Topics: Animals; Benzyl Alcohols; Caffeine; Calcium; Gene Expression; Glucosides; Heterotrimeric GTP-Binding Proteins; Humans; Male; Meiosis; Mice; Phenylthiourea; Probenecid; Protein Isoforms; Protein Subunits; Receptors, G-Protein-Coupled; RNA, Messenger; Seminiferous Tubules; Signal Transduction; Spermatids; Spermatogenesis; Taste	2013