caffeine and pentoxifylline

caffeine has been researched along with pentoxifylline in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (13.75)	18.7374
1990's	29 (36.25)	18.2507
2000's	21 (26.25)	29.6817
2010's	14 (17.50)	24.3611
2020's	5 (6.25)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Andersen, OA; Demartino, JA; Rao, FV; van Aalten, DM; Vora, KA	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Gwizdek-Wiśniewska, A; Piosik, J; Ulanowska, K; Wegrzyn, G	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Gołuński, G; Iermak, I; Piosik, J; Rychłowski, M; Woziwodzka, A	1
Mohamed, T; Osman, W; Rao, PP; Tin, G	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Aparicio, NJ; De Turner, E; Schwarzstein, L; Turner, D	1
Blank, KJ; Klyczek, KK; Rosenthal, LA	1
Carreras, A; Mendoza, C; Tesarik, J	1
Albertson, TE; Derlet, RW; Tseng, JC	1
Mitsumoto, Y; Mohri, T; Ohkubo, T	1
Averette, HE; Perras, J; Ramos, R; Schiano, MA; Sevin, BU; Wolloch, EH	1
Averette, HE; Boike, GM; Chou, TC; Donato, D; Hilsenbeck, SG; Penalver, M; Perras, J; Petru, E; Schiano, M; Sevin, BU	1
Chan, JC; Crowley, JJ; Hatherill, JR; Hoffmann, H; Ishizaka, A; Raffin, TA; Zheng, H	1
Ford, WC; Hull, MG; Rees, JM	1
Bedia, E; Donovan, JF; Hammitt, DG; Rogers, PR; Syrop, CH; Williamson, RA	1
Sasaki, T; Tomita, K; Tsuchiya, H	1
le Petit, G	1
Fredholm, BB; Lindström, K	1
Aguilar, JS; Lowenstein, PR; Sabato, UC	1
Chang, JD; Fingert, HJ; Pardee, AB	1
Boivin, P; Galand, C; Lecomte, MC	1
Boivin, P; Lecomte, MC	1
Jakovljević, V	1
Cardinali, DP; Izquierdo, JA	1
Kamphuis, J; Smits, P; Thien, T	1
Adams, EG; Bhuyan, BK; Folz, BA; Smith, KS	1
Hirota, S; Iwazaki, A; Miyagishima, A; Nozawa, Y; Sadzuka, Y	1
Charland, SL; Melko, GP; Stanek, EJ	1
Hosaka, M; Iwasaki, A; Kanno, H; Kawakami, Y; Kinoshita, Y; Saito, K; Sato, K	1
Scott, L; Smith, S	1
Greer, BE; Griffin, TW; Koh, WJ; Kurtz, H; Stelzer, KJ	1
Ford, WC; Hull, MG; Ling, L; McLaughlin, EA; Rees, JM	1
Chapman, MG; Forman, RG; Gearon, CM; Guglielmino, A; Lanzafame, F	1
Baker, GH; Johnston, RC; Mbizvo, MT	1
Agarwal, A; Sharma, RK; Thomas, AJ; Tolentino, MV	1
Agarwal, A; Sharma, RK; Tolentino, MV	1
Langermans, JA; Seijmonsbergen, EM; van der Meide, PH; van Furth, AM; van Furth, R	1
Barnes, RC; Carper, HT; Luong, LS; Mandell, GL; Sullivan, GW	1
Barancík, M; Breier, A; Stefanková, Z	1
Evans, G; Maxwell, WM; Molinia, FC; Robinson, SJ; Roca, J; Sánchez-Partida, LG	1
Akaike, N; Kawa, K; Uneyama, H	1
Aparicio, M; Cambar, J; Potier, M	1
Addae, JI; Evans, SM; Pinto Pereira, LM	1
Campos, AR; Paula, WG; Rao, VS; Santos, FA; Silva, RM	1
Daly, JW; Shi, D	1
Binder, A; Bohm, L; Theron, T	1
Korn, N; Parkhurst, AM; Thurston, RJ	1
Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO	1
Eshleman, JS; Sarkaria, JN	1
Czyz, A; Gwizdek-Wiśniewska, A; Kapuściński, J; Piosik, J; Ulanowska, K; Wegrzyn, G	1
Czyz, A; Gwizdek-Wiśniewska, A; Ochociński, J; Piosik, J; Ulanowska, K; Wegrzyn, G	1
Ulanowska, K; Wegrzyn, G	1
Anderson, CM; Thwaites, DT	1
Bulaeva, SV; Chuchkanov, FA; Maimistova, AA; Muravyov, AV; Yakusevich, VV; Zaitsev, LG	1
Horvath, B; Kesmarky, G; Toth, K; Vekasi, J	1
Budach, V; Grassl, B; Schroeder, G; Schulze, J; Sinn, B; Tallen, G; Tinhofer, I	1
Fontbonne, A; Gérard, O; Milani, C; Romagnoli, S; Sellem, E; Stelletta, C	1
Gwizdek-Wiśniewska, A; Piosik, J; Woziwodzka, A	1
Ebrahim-Habibi, A; Kashani-Amin, E; Larijani, B; Yaghmaei, P	1
Barakat, IA; Danfour, MA; Dkhil, MA; Galewan, FA	1
Byrne, PG; Keogh, LM; Silla, AJ	1
Batty, KT; Hibbert, J; Manning, L; Page-Sharp, M; Patole, SK; Salman, S; Strunk, T	1
Camillo, F; Ciaramelli, A; Panzani, D; Przybył, A; Rota, A; Sabatini, C	1
Falomo, ME; Gonzalez-Castro, R; Rossi, M	1
Al-Mahmood Siddiquee, A; Hashemian, F; Monji, F	1
Bachmann, CM; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Seyfried, M	1
Borowik, A; Felberg, A; Gołuński, G; Krychowiak-Maśnicka, M; Piosik, J; Woziwodzka, A; Wyrzykowski, D	1
Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J	1

Reviews

5 review(s) available for caffeine and pentoxifylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Xanthine interference with dipyridamole-thallium-201 myocardial imaging. The Annals of pharmacotherapy, 1995, Volume: 29, Issue:4 Topics: Adenosine; Animals; Caffeine; Coronary Disease; Dipyridamole; Dogs; False Negative Reactions; Heart; Humans; Male; Pentoxifylline; Radionuclide Imaging; Thallium Radioisotopes; Xanthine; Xanthines	1995
Pharmacological stimulation of sperm motility. Human reproduction (Oxford, England), 1994, Volume: 9, Issue:2 Topics: Caffeine; Deoxyadenosines; Humans; Infertility, Male; Male; Pentoxifylline; Relaxin; Sperm Motility; Theophylline	1994
ATM as a target for novel radiosensitizers. Seminars in radiation oncology, 2001, Volume: 11, Issue:4 Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle; Cell Cycle Proteins; Chromosome Aberrations; DNA Damage; DNA Repair; DNA-Binding Proteins; Humans; Neoplasms; Pentoxifylline; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Tumor Suppressor Proteins	2001
Can pentoxifylline and similar xanthine derivatives find a niche in COVID-19 therapeutic strategies? A ray of hope in the midst of the pandemic. European journal of pharmacology, 2020, Nov-15, Volume: 887 Topics: Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Infant, Newborn; Infant, Premature; Inflammation; Pandemics; Pentoxifylline; Pneumonia, Viral; Xanthines	2020

Other Studies

75 other study(ies) available for caffeine and pentoxifylline

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines	2002
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes. Chemistry & biology, 2005, Volume: 12, Issue:9 Topics: Chitinases; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Protein Binding; Xanthines	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Impaired mutagenic activities of MPDP(+) (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP(+) (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines. Bioorganic & medicinal chemistry, 2007, Aug-01, Volume: 15, Issue:15 Topics: 1-Methyl-4-phenylpyridinium; Caffeine; Calorimetry; Drug Interactions; Models, Molecular; Molecular Structure; Mutagens; Pentoxifylline; Pyridinium Compounds; Spectrophotometry, Atomic; Vibrio	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines--analysis with mathematical models. Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11 Topics: Aminacrine; Animals; Caffeine; Cattle; DNA; Drug Antagonism; Epithelial Cells; Intercalating Agents; Kidney; Kinetics; Models, Chemical; Mutagens; Nitrogen Mustard Compounds; Pentoxifylline; Salmonella typhimurium; Theophylline; Thermodynamics	2013
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Caffeine; Catalytic Domain; Cholinesterase Inhibitors; Humans; Hydrogen Bonding; Molecular Docking Simulation; Pentoxifylline; Protein Binding; Thermodynamics; Xanthine; Xanthines	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Effect of two phosphodiesterase inhibitors, cyclic adenosine 3':5'-monophosphate, and a beta-blocking agent on human sperm motility. Fertility and sterility, 1978, Volume: 29, Issue:3 Topics: Adolescent; Adult; Bucladesine; Caffeine; Humans; Male; Pentoxifylline; Propranolol; Sperm Motility; Theobromine; Time Factors	1978
Interferon-alpha/beta, pentoxifylline, and caffeine synergize with interferon-gamma to induce major histocompatibility complex class I expression on a constitutively class I-negative murine tumor cell line. Journal of interferon research, 1992, Volume: 12, Issue:6 Topics: Animals; Antibodies, Monoclonal; Caffeine; Cytokines; Dibutyryl Cyclic GMP; Drug Synergism; Flow Cytometry; Fluorescent Antibody Technique; Genes, MHC Class I; HLA-D Antigens; Interferon Type I; Interferon-gamma; Mice; Mice, Inbred BALB C; Pentoxifylline; Recombinant Proteins; Tumor Cells, Cultured	1992
Effects of phosphodiesterase inhibitors caffeine and pentoxifylline on spontaneous and stimulus-induced acrosome reactions in human sperm. Fertility and sterility, 1992, Volume: 58, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acrosome; Caffeine; Calcimycin; Female; Follicular Fluid; Humans; Male; Pentoxifylline	1992
Potentiation of cocaine and d-amphetamine toxicity with caffeine. The American journal of emergency medicine, 1992, Volume: 10, Issue:3 Topics: 2-Chloroadenosine; Animals; Caffeine; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Pentoxifylline; Poisoning; Rats; Rats, Inbred Strains; Seizures	1992
Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives. Neuroscience letters, 1991, Dec-09, Volume: 133, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Affinity Labels; Animals; Biological Transport; Caffeine; Cells, Cultured; Cytarabine; Dipyridamole; Embryo, Mammalian; Hippocampus; Kinetics; Neuroglia; Neurons; Pentoxifylline; Rats; Sodium; Theophylline; Thioinosine; Tritium; Xanthines	1991
In vitro enhancement of cis-platinum antitumor activity by caffeine and pentoxifylline in a human ovarian cell line. Gynecologic oncology, 1991, Volume: 43, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cell Cycle; Cell Survival; Cisplatin; DNA, Neoplasm; Drug Synergism; Female; Flow Cytometry; G2 Phase; Humans; Kinetics; Neoplasm Proteins; Nuclear Proteins; Ovarian Neoplasms; Pentoxifylline; Trypan Blue; Tumor Cells, Cultured	1991
Chemical enhancement of cisplatin cytotoxicity in a human ovarian and cervical cancer cell line. Gynecologic oncology, 1990, Volume: 38, Issue:3 Topics: Adenosine Triphosphate; Benzamides; Caffeine; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Humans; In Vitro Techniques; Ovarian Neoplasms; Pentoxifylline; Poly(ADP-ribose) Polymerases; Uterine Cervical Neoplasms	1990
Attenuation of tumor necrosis factor-induced endothelial cell cytotoxicity and neutrophil chemiluminescence. The American review of respiratory disease, 1990, Volume: 142, Issue:5 Topics: Aminophylline; Animals; Bucladesine; Caffeine; Cattle; Cell Survival; Cells, Cultured; Chromium Radioisotopes; Colforsin; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Neutrophils; Pentoxifylline; Tumor Necrosis Factor-alpha	1990
Effect of caffeine and of pentoxifylline on the motility and metabolism of human spermatozoa. Journal of reproduction and fertility, 1990, Volume: 90, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Caffeine; Humans; Male; Pentoxifylline; Sperm Motility; Spermatozoa; Stimulation, Chemical	1990
Comparison of motility stimulants for cryopreserved human semen. Fertility and sterility, 1989, Volume: 52, Issue:3 Topics: Adenosine; Animals; Caffeine; Calcium; Cricetinae; Cyclic AMP; Deoxyadenosines; Female; Humans; Kallikreins; Male; Pentoxifylline; Relaxin; Semen Preservation; Sperm Motility; Sperm-Ovum Interactions	1989
[DNA repair and drug resistance: enhancement of the effects of anticancer agents by DNA repair inhibitors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Cell Division; Child; Cisplatin; DNA Repair; Doxorubicin; Drug Resistance; Drug Synergism; Humans; Male; Middle Aged; Osteosarcoma; Pentoxifylline; Theophylline; Tumor Cells, Cultured	1989
[The pH-dependent lipid solubility of drug groups]. Die Pharmazie, 1985, Volume: 40, Issue:11 Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Caffeine; Clofibrate; Hydrogen-Ion Concentration; Lipids; Pentoxifylline; Pharmaceutical Preparations; Solubility	1985
The xanthine derivative 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine (HWA 285) enhances the actions of adenosine. Acta pharmacologica et toxicologica, 1986, Volume: 58, Issue:3 Topics: Adenosine; Animals; Biological Transport; Caffeine; Cyclic AMP; Drug Synergism; Erythrocyte Membrane; Hippocampus; Humans; Pentoxifylline; Rats; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Theobromine; Xanthines	1986
Effects of the methylxanthine derivative pentoxifylline on benzodiazepine and muscarinic binding sites in rat cerebral cortex. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia, 1985, Volume: 35, Issue:4 Topics: Animals; Binding, Competitive; Caffeine; Cerebral Cortex; Female; Flunitrazepam; Pentoxifylline; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Muscarinic; Theobromine	1985
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer research, 1986, Volume: 46, Issue:5 Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes; Drug Synergism; Humans; Interphase; Mechlorethamine; Pentoxifylline; Theobromine; Thiotepa; Urinary Bladder Neoplasms	1986
Inhibition of human erythrocyte casein kinase by methylxanthines. Study of inhibition mechanism. FEBS letters, 1980, Jul-11, Volume: 116, Issue:1 Topics: Caffeine; Casein Kinases; Caseins; Erythrocytes; Humans; Kinetics; Pentoxifylline; Protein Kinase Inhibitors; Protein Kinases; Theobromine	1980
Filterability and pharmacology. Effects of methylxanthine derivatives on red cell phosphorylation. Scandinavian journal of clinical and laboratory investigation. Supplementum, 1981, Volume: 156 Topics: Adenosine Triphosphate; Caffeine; Casein Kinases; Erythrocyte Membrane; Erythrocytes; Humans; Micropore Filters; Pentoxifylline; Phosphorylation; Protein Kinases; Xanthines	1981
[The effect of methylxanthine on myocardial excitability]. Medicinski pregled, 1982, Volume: 35, Issue:9-10 Topics: Animals; Caffeine; Female; Guinea Pigs; Heart Rate; Lidocaine; Male; Pentoxifylline; Xanthines	1982
Effect of caffeine, aminophylline and pentoxifylline on memory processes in mice. Acta physiologica latino americana, 1981, Volume: 31, Issue:3 Topics: Aminophylline; Animals; Caffeine; Male; Memory; Mice; Pentoxifylline; Theobromine	1981
Vascular effects of pentoxifylline in humans. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:4 Topics: Adenosine; Adult; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Female; Forearm; Hemodynamics; Humans; Infusions, Intra-Arterial; Male; Muscle, Smooth, Vascular; Pentoxifylline; Receptors, Purinergic P1; Vasodilation	1994
Synergistic and additive combinations of several antitumor drugs and other agents with the potent alkylating agent adozelesin. Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:6 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aphidicolin; Azacitidine; Benzofurans; Caffeine; Cell Survival; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Cyclohexanecarboxylic Acids; Cyclohexenes; Decitabine; Deoxyadenosines; DNA; Dose-Response Relationship, Drug; Drug Synergism; Duocarmycins; Indoles; Melanoma, Experimental; Melphalan; Mutagens; Organoplatinum Compounds; Pentoxifylline; Tumor Cells, Cultured	1995
Effects of methylxanthine derivatives on adriamycin concentration and antitumor activity. Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:6 Topics: Animals; Caffeine; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Synergism; Male; Mice; Pentoxifylline; Theobromine; Theophylline	1995
[Effect of caffeine and pentoxifylline on human sperm motility after one week storage at 3 degrees C]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1995, Volume: 86, Issue:4 Topics: Adult; Caffeine; Humans; Male; Pentoxifylline; Refrigeration; Semen Preservation; Sperm Motility; Time Factors	1995
Human sperm motility-enhancing agents have detrimental effects on mouse oocytes and embryos. Fertility and sterility, 1995, Volume: 63, Issue:1 Topics: Animals; Caffeine; Cyclic AMP; Deoxyadenosines; Embryo, Mammalian; Embryonic and Fetal Development; Female; Humans; Male; Mice; Parthenogenesis; Pentoxifylline; Sperm Motility	1995
Caffeine consumption is associated with decreased severe late toxicity after radiation to the pelvis. International journal of radiation oncology, biology, physics, 1994, Sep-30, Volume: 30, Issue:2 Topics: Caffeine; Endometrial Neoplasms; Female; Humans; Pelvis; Pentoxifylline; Radiation-Protective Agents; Radiotherapy; Retrospective Studies; Uterine Cervical Neoplasms	1994
Pentoxifylline acts synergistically with A23187 to increase the penetration of zona-free hamster oocytes by cryopreserved human spermatozoa. International journal of andrology, 1994, Volume: 17, Issue:4 Topics: Acrosome; Animals; Caffeine; Calcimycin; Cricetinae; Cryopreservation; Drug Synergism; Female; Humans; In Vitro Techniques; Male; Ovum; Pentoxifylline; Semen Preservation; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa; Zona Pellucida	1994
The effect of the motility stimulants, caffeine, pentoxifylline, and 2-deoxyadenosine on hyperactivation of cryopreserved human sperm. Fertility and sterility, 1993, Volume: 59, Issue:5 Topics: Caffeine; Computers; Cryopreservation; Deoxyadenosines; Humans; Male; Pentoxifylline; Semen Preservation; Sperm Motility; Spermatozoa	1993
Optimal dose and duration of exposure to artificial stimulants in cryopreserved human spermatozoa. The Journal of urology, 1996, Volume: 155, Issue:2 Topics: Caffeine; Cryopreservation; Deoxyadenosines; Humans; Male; Pentoxifylline; Sperm Motility; Spermatozoa; Stimulation, Chemical; Time Factors	1996
Sperm kinematics of cryopreserved normozoospermic specimens after artificial stimulation. Urology, 1996, Volume: 47, Issue:1 Topics: Caffeine; Cryopreservation; Deoxyadenosines; Humans; Male; Pentoxifylline; Sperm Motility	1996
Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes. Clinical and diagnostic laboratory immunology, 1995, Volume: 2, Issue:6 Topics: Caffeine; Cytokines; Dexamethasone; Glucocorticoids; Humans; Interleukin-1; Interleukin-10; Leukocytes; Pentoxifylline; Streptococcus pneumoniae; Theophylline; Tumor Necrosis Factor-alpha; Xanthines	1995
Methylxanthines with adenosine alter TNF alpha-primed PMN activation. Immunopharmacology, 1995, Volume: 31, Issue:1 Topics: Adenosine; Caffeine; Humans; Kinetics; Luminescent Measurements; Neutrophil Activation; Neutrophils; Pentoxifylline; Peroxidase; Superoxides; Tumor Necrosis Factor-alpha	1995
Overcoming of P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cells could be induced by pentoxifyline but not by theophylline and caffeine. Neoplasma, 1996, Volume: 43, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium; Calcium Channels; Drug Interactions; Drug Resistance, Neoplasm; Leukemia L1210; Mice; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha; Vincristine	1996
Motility, acrosome integrity and fertility of frozen ram spermatozoa treated with caffeine, pentoxifylline, cAMP, 2-deoxyadenosine and kallikrein. Reproduction, fertility, and development, 1995, Volume: 7, Issue:5 Topics: Acrosome; Animals; Caffeine; Cryopreservation; Cyclic AMP; Deoxyadenosines; Female; Fertilization; Kallikreins; Male; Pentoxifylline; Pregnancy; Sheep; Sperm Motility; Spermatozoa	1995
Inhibitory effect of methylxanthines on glycine-induced Cl current in dissociated rat hippocampal neurons. Annals of the New York Academy of Sciences, 1993, Dec-20, Volume: 707 Topics: Animals; Caffeine; Chloride Channels; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Pentoxifylline; Pyramidal Cells; Rats; Rats, Wistar; Theobromine; Theophylline; Xanthines	1993
Protective effect of three xanthine derivatives (theophylline, caffeine and pentoxifylline) against the cyclosporin A-induced glomerular contraction in isolated glomeruli and cultured mesangial cells. Nephron, 1997, Volume: 77, Issue:4 Topics: Animals; Caffeine; Cells, Cultured; Cyclosporine; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Immunosuppressive Agents; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Pentoxifylline; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1997
Neuroprotection by caffeine and pentoxifylline during experimental cerebral ischaemia. The West Indian medical journal, 1999, Volume: 48, Issue:1 Topics: Animals; Brain Ischemia; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal; Evoked Potentials, Somatosensory; Male; Neuroprotective Agents; Pentoxifylline; Premedication; Rats; Rats, Sprague-Dawley; Reperfusion; Time Factors; Vasodilator Agents	1999
Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test. Psychopharmacology, 1999, Volume: 144, Issue:1 Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pentoxifylline	1999
Chronic effects of xanthines on levels of central receptors in mice. Cellular and molecular neurobiology, 1999, Volume: 19, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines	1999
Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochimica et biophysica acta, 2000, Dec-11, Volume: 1499, Issue:1-2 Topics: Caffeine; Cell Cycle; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Gentian Violet; Growth Inhibitors; Humans; Indicators and Reagents; Mitosis; Molecular Structure; Nocodazole; Pentoxifylline; Radiation-Sensitizing Agents; S Phase; Time Factors; Tumor Cells, Cultured; Xanthines	2000
The effects of methylxanthines on the mobility of stored turkey sperm. Poultry science, 2000, Volume: 79, Issue:12 Topics: Animals; Caffeine; Fertility; Male; Pentoxifylline; Semen Preservation; Sperm Motility; Time Factors; Turkeys; Xanthines	2000
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:3 Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines	2001
Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutation research, 2003, Sep-29, Volume: 530, Issue:1-2 Topics: Aminacrine; Aminoacridines; Antimutagenic Agents; Caffeine; Models, Molecular; Mutagenicity Tests; Mutagens; Nitrogen Mustard Compounds; Pentoxifylline; Polycyclic Aromatic Hydrocarbons; Quinacrine Mustard; Vibrio	2003
Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone. Acta biochimica Polonica, 2005, Volume: 52, Issue:4 Topics: Antimutagenic Agents; Caffeine; Cell Survival; Daunorubicin; Doxorubicin; Mitoxantrone; Mutagenicity Tests; Pentoxifylline; Structure-Activity Relationship; Theophylline; Vibrio; Xanthenes	2005
Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of applied genetics, 2006, Volume: 47, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminoacridines; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Caffeine; Central Nervous System Stimulants; Doxorubicin; Free Radical Scavengers; Mutagenicity Tests; Neurotoxins; Nitrogen Mustard Compounds; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Vibrio	2006
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3). Biochimica et biophysica acta, 2007, Volume: 1768, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline	2007
Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. Clinical hemorheology and microcirculation, 2007, Volume: 36, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Adult; Blood Viscosity; Caffeine; Calcimycin; Calcium; Egtazic Acid; Erythrocyte Aggregation; Hemorheology; Humans; Male; Nifedipine; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Verapamil; Vinca Alkaloids	2007
In vitro antioxidant properties of pentoxifylline and vinpocetine in a rheological model. Clinical hemorheology and microcirculation, 2008, Volume: 40, Issue:2 Topics: Adult; Blood Viscosity; Caffeine; Calcimycin; Calcium; Egtazic Acid; Erythrocyte Aggregation; Free Radical Scavengers; Hemorheology; Humans; Male; Nifedipine; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Verapamil; Vinca Alkaloids	2008
Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation. Molecular cancer therapeutics, 2010, Volume: 9, Issue:2 Topics: Animals; Brain Neoplasms; Caffeine; Cell Line, Tumor; Cell Survival; DNA Damage; G1 Phase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, p53; Glioma; Humans; Mice; Mutation; Pentoxifylline; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Radiation, Ionizing	2010
Effect of post-thaw dilution with caffeine, pentoxifylline, 2'-deoxyadenosine and prostatic fluid on motility of frozen-thawed dog semen. Theriogenology, 2010, Jul-01, Volume: 74, Issue:1 Topics: Animals; Body Fluids; Caffeine; Cell Survival; Cryopreservation; Deoxyadenosines; Dogs; Hot Temperature; Male; Pentoxifylline; Prostate; Semen Preservation; Solutions; Sperm Motility; Spermatozoa	2010
Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines. Bioorganic chemistry, 2011, Volume: 39, Issue:1 Topics: Amines; Caffeine; Calorimetry; Carcinogens; Heterocyclic Compounds; Mutagenicity Tests; Pentoxifylline; Salmonella typhimurium; Spectrum Analysis; Theophylline; Vibrio; Xanthines	2011
Xanthine derivatives as activators of alpha-amylase: hypothesis on a link with the hyperglycemia induced by caffeine. Obesity research & clinical practice, 2013, Volume: 7, Issue:6 Topics: Animals; Blood Glucose; Caffeine; Enzyme Activation; Enzyme Inhibitors; Hyperglycemia; Pancreas; Pancreatic alpha-Amylases; Pentoxifylline; Starch; Swine; Theobromine	2013
Effect of various concentrations of caffeine, pentoxifylline, and kallikrein on hyperactivation of frozen bovine semen. BioMed research international, 2015, Volume: 2015 Topics: Animals; Caffeine; Cattle; Cryopreservation; Fertilization; Humans; Kallikreins; Male; Pentoxifylline; Semen Preservation; Sperm Motility; Spermatozoa	2015
Sperm motility activation in the critically endangered booroolong frog: the effect of medium osmolality and phosphodiesterase inhibitors. Reproduction, fertility, and development, 2017, Volume: 29, Issue:11 Topics: Animals; Anura; Caffeine; Fertilization in Vitro; Male; Osmolar Concentration; Pentoxifylline; Phosphodiesterase Inhibitors; Semen Analysis; Sperm Motility; Spermatozoa; Theophylline	2017
Simultaneous determination of pentoxifylline, metabolites M1 (lisofylline), M4 and M5, and caffeine in plasma and dried blood spots for pharmacokinetic studies in preterm infants and neonates. Journal of pharmaceutical and biomedical analysis, 2017, Nov-30, Volume: 146 Topics: Caffeine; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Humans; Infant, Newborn; Infant, Premature; Pentoxifylline; Plasma; Tandem Mass Spectrometry	2017
Post-thaw Addition of Caffeine and/or Pentoxifylline Affect Differently Motility of Horse and Donkey-Cryopreserved Spermatozoa. Journal of equine veterinary science, 2019, Volume: 75 Topics: Animals; Caffeine; Equidae; Female; Horses; Humans; Male; Pentoxifylline; Pregnancy; Sperm Motility; Spermatozoa	2019
Effect of Caffeine and Pentoxifylline Added Before or After Cooling on Sperm Characteristics of Stallion Sperm. Journal of equine veterinary science, 2020, Volume: 87 Topics: Animals; Caffeine; Fertility; Horses; Male; Pentoxifylline; Sperm Motility; Spermatozoa	2020
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells. International journal of molecular sciences, 2020, Nov-27, Volume: 21, Issue:23 Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans; Neuroblastoma; Pentoxifylline; Principal Component Analysis; Theobromine; Theophylline; Transcription, Genetic; Xanthines	2020
Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation. Molecules (Basel, Switzerland), 2021, Jun-14, Volume: 26, Issue:12 Topics: Anti-Bacterial Agents; Bacteria; Caffeine; Central Nervous System Stimulants; Drug Interactions; Heterocyclic Compounds; Microbial Sensitivity Tests; Pentoxifylline; Phosphodiesterase Inhibitors	2021
Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. International journal of molecular sciences, 2022, Feb-18, Volume: 23, Issue:4 Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuroblastoma; Neurodegenerative Diseases; Pentoxifylline; Theobromine; Theophylline; Triglycerides; Xanthines	2022