caffeine and orphenadrine

caffeine has been researched along with orphenadrine in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199016 (51.61)18.7374
1990's0 (0.00)18.2507
2000's1 (3.23)29.6817
2010's8 (25.81)24.3611
2020's6 (19.35)2.80

Authors

AuthorsStudies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Gundersen, R; Høivik, HO; Osmundsen, K1
Backe-Hansen, K; Skinnemoen, BE; Smit, A1
Nathan, LA1
Batterman, RC2
Frascá, ID1
Albertoni, WM; Fiori, EF; Frascá, ID; Frascá, JA; Pires, OS1
McClure, DA1
Dinan, B; Jick, H; Muench, H; Slone, D1
Bianchine, JR; Goldlust, MB; Harrison, LI; Kehe, CR; Kvam, DC1
Guay, DR; Meatherall, RC1
CASS, LJ; FREDERIK, WS2
BLUMENTHAL, LS; FUCHS, M1
GOLDSTEIN, L; MURPHREE, HB; PFEIFFER, CC; SUGERMAN, AA1
Darwish, K; El-Sadek, M; Mostafa, S; Salama, I1
Abdelrahman, MM1
Farhoudian, A; Fekri, M; Movaghar, AR; Rahimzadeh, S; Sadeghi, M; Sefatian, S; Vishteh, HR1
Boltia, SA; Elzanfaly, ES; Soudi, AT; Zaazaa, HE2
El-Adl, SM; Mattar, AA; Sebaiy, MM1
Correia, AT; de Oliveira, TMN; Guimarães, LL; Pisetta, AM; Roveri, V1
Correia, AT; Guimarães, LL; Roveri, V; Toma, W1

Reviews

1 review(s) available for caffeine and orphenadrine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for caffeine and orphenadrine

ArticleYear
[Combined analgesics in myalgia of the neck. A double-blind comparison of paracetamol and orphenadrine (Norgesic) and paracetamol and codeine (Paralgin forte) in general practice].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1986, Jan-20, Volume: 106, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Muscles; Neck Muscles; Orphenadrine; Pain

1986
Methodology of analgesic evaluation: experience with orphenadrine citrate compound.
    Current therapeutic research, clinical and experimental, 1965, Volume: 7, Issue:10

    Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Evaluation Studies as Topic; Humans; Orphenadrine; Phenacetin

1965
Norgesic.
    The Medical letter on drugs and therapeutics, 1965, Mar-26, Volume: 7, Issue:7

    Topics: Aspirin; Caffeine; Clinical Trials as Topic; Humans; Orphenadrine; Phenacetin

1965
Methodology of analgesic-muscle relaxant evaluation. Experience with orphenadrine citrate compound.
    Proceedings of the Western Pharmacology Society, 1965, Volume: 8

    Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Female; Humans; Male; Muscles; Orphenadrine; Pain; Phenacetin

1965
Evaluation of drug efficacy by a preference technic.
    The New England journal of medicine, 1966, Dec-22, Volume: 275, Issue:25

    Topics: Arthritis, Rheumatoid; Aspirin; Caffeine; Dexamethasone; Dextropropoxyphene; Humans; Hypnotics and Sedatives; Orphenadrine; Phenacetin; Secobarbital

1966

Other Studies

25 other study(ies) available for caffeine and orphenadrine

ArticleYear
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
On the Nordic Pharmacopoeia limit test for heavy metals. Heating with anhydrous sodium sulphate as a source of error.
    Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:3

    Topics: Cadmium; Caffeine; Chlorine; Copper; Hot Temperature; Iron; Lead; Metals; Methods; Norway; Orphenadrine; Pharmacopoeias as Topic; Silicon Dioxide; Sodium; Spectrum Analysis; Sulfates

1974
Dysmenorrhea and pre-menstrual tension in adolescents.
    IMJ. Illinois medical journal, 1967, Volume: 131, Issue:2

    Topics: Adolescent; Aspirin; Caffeine; Dysmenorrhea; Female; Humans; Orphenadrine; Phenacetin; Premenstrual Syndrome

1967
[New muscle relaxant analgesic in orthopedics and traumatology. Preliminary note].
    Hospital (Rio de Janeiro, Brazil), 1970, Volume: 77, Issue:1

    Topics: Adolescent; Adult; Aged; Caffeine; Female; Humans; Male; Middle Aged; Muscular Diseases; Orphenadrine; Pyrazoles; Sulfonic Acids; Wounds and Injuries

1970
[New muscle relaxant analgesic in orthopedics and traumatology (final evaluation of 100 treated cases)].
    Hospital (Rio de Janeiro, Brazil), 1970, Volume: 78, Issue:2

    Topics: Adolescent; Adult; Analgesics; Caffeine; Female; Humans; Male; Middle Aged; Muscle Contraction; Neuromuscular Depolarizing Agents; Orphenadrine; Orthopedics; Pyrazoles; Sulfonic Acids; Wounds and Injuries

1970
The poteniation of the analgesic action of APC by orphenadrine citrate.
    Proceedings of the Western Pharmacology Society, 1965, Volume: 8

    Topics: Animals; Aspirin; Caffeine; Drug Synergism; Electric Stimulation; Mice; Orphenadrine; Phenacetin

1965
Salicylic acid plasma levels following multiple doses of Norgesic Forte and aspirin.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:4

    Topics: Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Kinetics; Male; Orphenadrine; Salicylates; Salicylic Acid

1983
Isothermal gas chromatographic analysis of diphenhydramine after direct injection onto a fused-silica capillary column.
    Journal of chromatography, 1984, May-11, Volume: 307, Issue:2

    Topics: Caffeine; Chromatography, Gas; Diphenhydramine; Humans; Orphenadrine; Time Factors

1984
AN EVALUATION OF ORPHENADRINE CITRATE IN COMBINATION WITH APC AS AN ANALGESIC.
    Current therapeutic research, clinical and experimental, 1964, Volume: 6

    Topics: Analgesics; Aspirin; Biomedical Research; Caffeine; Humans; Orphenadrine; Pharmacology; Phenacetin; Placebos

1964
THE EVOLUTION OF A NEW ANALGESIC THROUGH CLINICAL STUDIES: A COMPARATIVE CLINICAL INVESTIGATION.
    The American journal of the medical sciences, 1964, Volume: 248

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Biomedical Research; Caffeine; Codeine; Orphenadrine; Pharmacology; Phenacetin; Placebos; Toxicology

1964
ANALGESIC COMBINATION IN HEADACHE.
    Headache, 1965, Volume: 5

    Topics: Analgesics; Arthritis; Aspirin; Back Pain; Caffeine; Cervical Vertebrae; Drug Therapy; Headache; Humans; Intervertebral Disc Displacement; Lumbosacral Region; Orphenadrine; Osteoarthritis; Phenacetin; Torticollis; Toxicology

1965
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Deanol; Drug Therapy; Electroencephalography; Lysergic Acid Diethylamide; Meprobamate; Orphenadrine; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Placebos; Schizophrenia; Statistics as Topic; Tranquilizing Agents

1965
Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Limit of Detection; Muscarinic Antagonists; Orphenadrine

2012
Selective spectrophotometric methods for determination of ternary mixture with overlapping spectra: a comparative study.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014, Apr-24, Volume: 124

    Topics: Area Under Curve; Aspirin; Caffeine; Chemistry, Pharmaceutical; Kinetics; Methanol; Orphenadrine; Reference Standards; Spectrophotometry

2014
A tentative component analysis of Norjizak: A new abused drug in Iran.
    Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:5

    Topics: Aspirin; Betamethasone; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Codeine; Drug Combinations; Heroin; Iran; Orphenadrine; Substance-Related Disorders

2015
Effect of Genetic Algorithm-Based Wavelength Selection as a Preprocessing Tool on Multivariate Simultaneous Determination of Paracetamol, Orphenadrine Citrate, and Caffeine in the Presence of p-Aminophenol Impurity.
    Journal of AOAC International, 2020, Jan-01, Volume: 103, Issue:1

    Topics: Acetaminophen; Algorithms; Aminophenols; Caffeine; Calibration; Least-Squares Analysis; Orphenadrine

2020
Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2020, Jan-05, Volume: 224

    Topics: Acetaminophen; Caffeine; Diclofenac; Linear Models; Models, Chemical; Orphenadrine; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2020
Development and Validation of Chromatographic Methods for Simultaneous Determination of Paracetamol, Orphenadrine Citrate and Caffeine in Presence of P-aminophenol; Quantification of P-aminophenol Nephrotoxic Impurity Using LC-MS/MS.
    Journal of chromatographic science, 2020, Apr-22, Volume: 58, Issue:3

    Topics: Acetaminophen; Aminophenols; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Reverse-Phase; Chromatography, Thin Layer; Densitometry; Drug Contamination; Excipients; Orphenadrine; Tablets; Tandem Mass Spectrometry

2020
Orphengesic Forte - an old analgesic combination returns.
    The Medical letter on drugs and therapeutics, 2020, 11-16, Volume: 62, Issue:1611

    Topics: Analgesics; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Drug Interactions; Humans; Musculoskeletal Pain; Orphenadrine

2020
First report on the occurrence of pharmaceuticals and cocaine in the coastal waters of Santa Catarina, Brazil, and its related ecological risk assessment.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:42

    Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Cosmetics; Diclofenac; Ecosystem; Environmental Monitoring; Humans; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Sewage; Solid Waste; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical

2022
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:59

    Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical

2022