caffeine and morphine
caffeine has been researched along with morphine in 174 studies
Research
Studies (174)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (49.43) | 18.7374 |
| 1990's | 29 (16.67) | 18.2507 |
| 2000's | 37 (21.26) | 29.6817 |
| 2010's | 22 (12.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Jolivette, LJ; Ward, KW | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Collier, HO | 1 |
| Geber, WF; Hung, CY; Lefkowitz, SS | 1 |
| Collier, HO; Francis, DL; Roy, AC | 2 |
| Butt, NM; Collier, HO; Cuthbert, NJ; Francis, DL; Saeed, SA | 1 |
| Jhamandas, K; Sawynok, J; Sutak, M | 1 |
| Endell, W; Seidel, G | 1 |
| Lefkowitz, SS; Nemeth, D | 1 |
| Hosoya, E; Oka, T | 1 |
| Borisenko, SA; Burov, IuV | 1 |
| Chiang, CY; Lefkowitz, SS | 1 |
| Mariathasan, EA; Stolerman, IP | 1 |
| Kuribara, H; Tadokoro, S; Uchihashi, Y | 1 |
| Layer, RT; Uretsky, NJ; Wallace, LJ | 1 |
| Leza, JC; Lizasoain, I; Lorenzo, P; Navarro, M | 1 |
| Evans, EB; Wenger, GR | 1 |
| Kuribara, H; Tadokoro, S | 2 |
| Asami, T; Ida, I; Kuribara, H; Machiyama, Y; Tadokoro, S | 1 |
| Cai, B; Matsumoto, K; Nakamura, S; Watanabe, H | 1 |
| Furusawa, K; Tadokoro, S | 1 |
| Contreras, E; Germany, A; Villar, M | 1 |
| DeLander, GE; Hopkins, CJ | 1 |
| Ahlijanian, MK; Takemori, AE | 4 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Kaschube, M; Strubelt, O; Zetler, G | 1 |
| Ehlers, CL; Koob, GF | 1 |
| Misra, AL; Pontani, RB; Vadlamani, NL | 1 |
| Bradley, EL; Brown, PT; Kissin, I; Person, DL; Vinik, HR; Xavier, AV | 1 |
| Estler, CJ | 1 |
| Berger, H | 1 |
| Rentsch, G; Staubesand, J; Wittekind, D | 1 |
| Dodds, JP; Klein, F; Lincoln, RE; Mahlandt, BG; Walker, JS | 1 |
| Greengard, P; Quinn, GP; Reid, MB | 1 |
| Oswald, I | 1 |
| Quilliam, JP; Tamarind, DL | 1 |
| Conine, F; Paul, J | 1 |
| Mennear, JH; Rudzik, AD | 1 |
| Bauer, G; Konzett, H; Ziegler, E | 1 |
| Sugano, H; Ueki, S | 1 |
| Chiba, S; Nagawa, Y; Yui, T | 1 |
| Nichols, RE; Patterson, CS; Walaszek, EJ | 1 |
| Oldendorf, WH | 1 |
| Bellin, JS; Sorrentino, GM | 1 |
| Saito, H; Takagi, K; Yoshida, Y | 1 |
| Fog, R | 1 |
| Vorherr, H | 1 |
| Behnsen, G; Kühn, L; Pfeifer, S | 1 |
| Jurand, J; Knox, JH | 1 |
| Gorodetzky, CW; Kullberg, MP | 1 |
| Abola, EE; Deutsch, HF; Edmundson, AB; Ely, KR; Fausch, MD; Girling, RL; Schiffer, M; Westholm, FA | 1 |
| el-Darawy, ZI; Mobarak, ZM | 1 |
| Feingold, A; Miller, RR; Paxinos, J | 1 |
| Hansen, AB | 1 |
| Bass, WC; Brown, H | 1 |
| Deneau, G; Seevers, MH; Yanagita, T | 1 |
| Matsuda, K | 1 |
| Baden, MM; Valanju, NN; Valanju, SN; Verma, SK | 1 |
| Lasagna, L | 1 |
| McClure, DA | 1 |
| Molinengo, L; Ricci-Gamalero, S | 1 |
| Senault, B | 1 |
| Coville, PF; Telford, JM | 1 |
| Barbaz, BS; Bernard, PS; Chernov, HI; DeStevens, G; Partyka, DA; Wilson, DE | 1 |
| Dítĕ, P; Krízala, JF; Krupar, V; Sita, F | 1 |
| Borazan, HN; Goyan, FM | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| Novikov, FE | 1 |
| Soroka, VR | 1 |
| McMartin, C; Street, HV | 1 |
| Gen, MC; Valdman, AV | 1 |
| Collins, RJ; Simonton, VR | 1 |
| Mantegazza, P; Tammiso, R; Zambotti, F; Zecca, L; Zonta, N | 1 |
| Phillis, JW; Wu, PH | 1 |
| Elliott, J; Jhamandas, K; Notman, H; Sutak, M | 1 |
| Emley, GS; Hutchinson, RR | 1 |
| Kawai, T; Masukawa, Y; Suzuki, T; Yanaura, S; Yoshii, T | 1 |
| Jebeles, JA; Kissin, I | 1 |
| Contreras, E; Juica, S; Tamayo, L | 1 |
| DeAngelis, RL; Findlay, JM; Findlay, JW; Kearney, MF; Welch, RM | 1 |
| Chelack, BJ; Jiang, ZG; Phillis, JW | 1 |
| Ator, NA; Sannerud, CA | 1 |
| Smith, FL; Stevens, DL | 1 |
| Adachi, K | 1 |
| Kuribara, H | 1 |
| Kuribara, H; Uchihashi, Y | 1 |
| Kaa, E | 1 |
| Holtzman, SG; Woolfolk, DR | 1 |
| Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL | 1 |
| Graham, NB; McNeill, ME | 1 |
| Hyötyläinen, T; Riekkola, ML; Sirén, H | 1 |
| Kasaba, T; Takasaki, M; Takeshita, M | 1 |
| Garcia, MM; Harlan, RE | 1 |
| Antelman, SM; Austin, MC; Caggiula, AR; Edwards, DJ; Fowler, H; Gershon, S; Kucinski, BJ | 1 |
| Coyle, TS; Kaplan, GB | 1 |
| Dewey, WL; Dombrowski, DS; Smith, FL | 1 |
| Kaplan, GB; Weisberg, SP | 1 |
| Partridge, B; Schenk, S | 1 |
| Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M | 1 |
| Fogle, CM; Mayorga, AJ; Paule, MG; Popke, EJ | 1 |
| Fathollahi, Y; Khalili, M; Semnanian, S | 1 |
| Casuccio, A; Mercadante, S; Serretta, R | 1 |
| Burgalassi, S; Chetoni, P; Giannelli, R; Monti, D | 1 |
| Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C | 1 |
| Figurina, IV; Lyupina, YV; Medvedeva, OF; Papazov, IP; Rusakova, IV; Sudakov, SK | 1 |
| Figurina, IB; Medvedeva, OF; Rusakova, IV; Sudakov, SK | 1 |
| Arneric, SP; Bain, JN; Buccafusco, JJ; Prendergast, MA; Smith, MA; Terry, AV | 1 |
| Beardsley, PM; Cook, CD | 1 |
| Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR | 1 |
| Li, M; McMillan, DE | 1 |
| PRATESI, F | 1 |
| D'ALBA, A; GAMNA, G; VILLATA, E | 1 |
| NICHTERN, S | 1 |
| JACOB, J; MICHAUD, G | 1 |
| BELLVILLE, JW; ESCARRAGA, LA; HOUDE, RW; HOWLAND, WS; WALLENSTEIN, SL; WANG, KC | 1 |
| BOHDANECKY, Z; NECINA, J | 1 |
| BLOOMQUIST, ER | 1 |
| HUGGINS, CG; SMITH, CM; WALASZEK, EJ | 1 |
| WHITE, RP | 1 |
| CHENG, K; SHENG, PH; SHIH, YY; TAN, YH; TAO, CY; TSAI, CC | 1 |
| BELLVILLE, JW | 1 |
| BESSIN, P; BOISSIER, JR; DUMONT, C | 1 |
| Abo-Salem, OM; Bilkei-Gorzo, A; Filipek, B; Hayallah, AM; Müller, CE; Zimmer, A | 1 |
| Caboche, J; Girault, JA; Hervé, D; Pagès, C; Valjent, E | 1 |
| Medvedeva, OF; Rusakova, IV; Sudakov, SK | 1 |
| Aragon, CM; Miquel, M; Pastor, R | 1 |
| Hnasko, TS; Palmiter, RD; Sotak, BN | 1 |
| Bezard, E; Bilbao, A; Chen, JF; Cippitelli, A; Granado, N; Martín, AB; Moratalla, R; Navarro, M; Ortiz, O; Rodríguez de Fonseca, F | 1 |
| Bonnaire, Y; Julliand, V; Lallemand, A; Respondek, F | 1 |
| Armstrong, EA; Black, AM; Clark, D; Pandya, S; Yager, JY | 1 |
| Bertol, E; Mari, F; Politi, L | 1 |
| Capasso, A; Gallo, C | 1 |
| Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW | 1 |
| Aly, A; Farouk, S | 1 |
| Amri, H; Bartels, B; Beeson, E; Bergner, C; Cachat, J; Canavello, P; Chung, A; Chung, KM; Duncan, A; Egan, R; Elegante, M; Elkhayat, S; Gaikwad, S; Gilder, T; Goodspeed, J; Grimes, C; Hart, P; Kadri, F; Kalueff, AV; Mohnot, S; Rosenberg, M; Roy, S; Soignier, RD; Stewart, A; Suciu, C; Tan, J; Tien, D; Wong, K; Zapolsky, I; Zukowska, Z | 1 |
| Sawynok, J | 1 |
| Kleine-Brüggeney, M; Kranke, P; Stamer, UM | 1 |
| Chan, KW; Tan, GH; Wong, RC | 1 |
| Barbera, N; Busardò, FP; Indorato, F; Romano, G | 1 |
| Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J | 1 |
| Radke, K; Radke, OC | 1 |
| Basurto Ona, X; Bonfill Cosp, X; Martínez García, L; Solà, I; Uriona Tuma, SM | 1 |
| Bévalot, F; Bottinelli, C; Cartiser, N; Fanton, L; Guitton, J | 1 |
| Haji, A; Kimura, S; Ohi, Y | 1 |
| Andersson, M; Beck, O; Björkhem-Bergman, L | 1 |
| Costa, G; Morelli, M; Simola, N | 1 |
| Mohs, AJ; Peace, MR; Poklis, A; Poklis, JL; Wolf, CE | 1 |
| Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M | 1 |
| Loney, GC; Meyer, PJ | 1 |
| Baranowska, I; Baranowski, J; Pochopień, G | 1 |
Reviews
13 review(s) available for caffeine and morphine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Opiates, cyclic nucleotides, and xanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caffeine; Cyclic AMP; Dopamine; Enzyme Activation; Humans; Lung; Morphine; Narcotics; Prostaglandins E; Theophylline; Xanthines | 1976 |
Drugs and sleep.
Topics: Aminobutyrates; Amphetamine; Animals; Antidepressive Agents; Barbiturates; Caffeine; Cats; Clinical Trials as Topic; Dihydroxyphenylalanine; Dreams; Drug Utilization; Ethanol; Hormones; Humans; Hydroxybutyrates; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Methods; Monoamine Oxidase Inhibitors; Morphine; Nicotine; Parasympatholytics; Parasympathomimetics; Phenytoin; Rats; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tryptophan | 1968 |
On stereotypy and catalepsy: studies on the effect of amphetamines and neuroleptics in rats.
Topics: Amphetamine; Animals; Basal Ganglia; Caffeine; Catalepsy; Cocaine; Compulsive Behavior; Corpus Striatum; Disease Models, Animal; Dopamine; Hippocampus; Humans; Lysergic Acid Diethylamide; Methamphetamine; Methylphenidate; Morphine; Norepinephrine; Pemoline; Phenmetrazine; Psychoses, Substance-Induced; Rats; Reserpine; Thalamus; Tranquilizing Agents | 1972 |
Drug excretion in breast milk.
Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; Chloramphenicol; Contraceptives, Oral; Coumarins; Female; Fluorine; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Lactation; Meprobamate; Milk, Human; Models, Biological; Morphine; Nicotine; Pesticides; Pharmaceutical Preparations; Phenytoin; Potassium Iodide; Pregnancy; Salicylates; Sulfonamides; Time Factors | 1974 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headache; Humans; Indoles; Isoquinolines; Meperidine; Morphine; Nalorphine; Narcotics; Pain; Periodontal Diseases; Phenacetin; Placebos; Postoperative Care; Pregnancy; Puerperal Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents | 1970 |
[Direct quantitative thin-layer chromatography by remission and transmission measurement. A review].
Topics: Adsorption; Aspirin; Caffeine; Carbon Isotopes; Chromatography, Thin Layer; Codeine; Densitometry; Glucose; Morphine; Noscapine; Papaverine; Saponins; Thebaine; Tyrosine | 1971 |
The role of adenosine and its nucleotides in central synaptic transmission.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Triphosphatases; Animals; Axonal Transport; Behavior, Animal; Benzodiazepines; Brain; Caffeine; Morphine; Nucleotidases; Receptors, Cell Surface; Receptors, Purinergic; Synapses | 1981 |
Drugs of abuse and immediate-early genes in the forebrain.
Topics: Amphetamines; Animals; Caffeine; Cocaine; Dronabinol; Gene Expression Regulation; Genes, Immediate-Early; Humans; Illicit Drugs; Immediate-Early Proteins; Morphine; Nicotine; Prosencephalon; Substance-Related Disorders | 1998 |
Methylxanthines and pain.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interactions; Humans; Morphine; Pain | 2011 |
[Prophylaxis and therapy of postdural puncture headache--a critical evaluation of treatment options].
Topics: Adrenocorticotropic Hormone; Adult; Analgesics; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Female; Humans; Injections, Spinal; Morphine; Post-Dural Puncture Headache; Pregnancy; Serotonin Antagonists; Theophylline; Vasodilator Agents | 2011 |
[Post-dural puncture headache].
Topics: Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Blood Patch, Epidural; Caffeine; Central Nervous System Stimulants; Diagnosis, Differential; Dura Mater; Humans; Morphine; Needles; Post-Dural Puncture Headache; Theophylline; Vasodilator Agents | 2013 |
Drug therapy for preventing post-dural puncture headache.
Topics: Adult; Aminophylline; Analgesics; Caffeine; Child; Cosyntropin; Dexamethasone; Drug Administration Routes; Female; Fentanyl; Humans; Indomethacin; Male; Morphine; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture | 2013 |
Trials
6 trial(s) available for caffeine and morphine
| Article | Year |
|---|---|
Drugs and sleep.
Topics: Aminobutyrates; Amphetamine; Animals; Antidepressive Agents; Barbiturates; Caffeine; Cats; Clinical Trials as Topic; Dihydroxyphenylalanine; Dreams; Drug Utilization; Ethanol; Hormones; Humans; Hydroxybutyrates; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Methods; Monoamine Oxidase Inhibitors; Morphine; Nicotine; Parasympatholytics; Parasympathomimetics; Phenytoin; Rats; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tryptophan | 1968 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headache; Humans; Indoles; Isoquinolines; Meperidine; Morphine; Nalorphine; Narcotics; Pain; Periodontal Diseases; Phenacetin; Placebos; Postoperative Care; Pregnancy; Puerperal Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents | 1970 |
Drug interaction in the field of analgesic drugs.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Cyclazocine; Drug Synergism; Humans; Meperidine; Methotrimeprazine; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine; Phenacetin; Placebos; Tranquilizing Agents; Triflupromazine | 1965 |
Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study.
Topics: Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Morphine; Neoplasms; Pain | 2001 |
Urinary excretion of dietary contaminants in horses.
Topics: Animals; Atropine; Bufotenin; Caffeine; Cross-Over Studies; Doping in Sports; Dose-Response Relationship, Drug; Food Contamination; Horses; Morphine; N,N-Dimethyltryptamine; Physical Conditioning, Animal; Scopolamine; Theobromine; Theophylline | 2006 |
A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Bupivacaine; Caffeine; Codeine; Double-Blind Method; Drug Combinations; Female; Humans; Injections, Intra-Articular; Magnesium Sulfate; Male; Morphine; Pain Measurement; Pain, Postoperative | 2009 |
Other Studies
157 other study(ies) available for caffeine and morphine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Consequences of interaction between opioid and receptor.
Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Ileum; Models, Biological; Morphine; Neurons; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1977 |
Effect of morphine, hydromorphone, methadone, mescaline, trypan blue, vitamin A, sodium salicylate, and caffeine on the serum interferon level in response to viral infection.
Topics: Animals; Caffeine; Hydromorphone; Interferons; Male; Mescaline; Methadone; Mice; Morphine; Salicylates; Trypan Blue; Vesicular stomatitis Indiana virus; Virus Diseases; Vitamin A | 1975 |
Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Male; Morphine; Naloxone; Phosphodiesterase Inhibitors; Prostaglandins; Rats; Structure-Activity Relationship; Substance Withdrawal Syndrome; Theophylline; Time Factors; Xanthines | 1975 |
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans; Male; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Xanthines | 1979 |
Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium.
Topics: Acetylcholine; Animals; Brain; Caffeine; Calcium; Chlorpromazine; Morphine; Rats; Theophylline; Xanthines | 1978 |
Prolonged action of drugs in rats with flavonoid-deficiency.
Topics: Animals; Barbiturates; Behavior, Animal; Caffeine; Diet; Flavonoids; Harmine; Male; Morphine; Pharmaceutical Preparations; Rats; Time Factors | 1978 |
Immunosuppression of rosette-forming cells.
Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; Immunosuppression Therapy; Leukocytes; Male; Methadone; Mice; Morphine; Organ Size; Pentobarbital; Phenobarbital; Sheep; Spleen; Substance-Related Disorders | 1976 |
The different effect of humoral modulators on the morphine- and central nervous system stimulant-induced hyperactivity of rats.
Topics: Acetylcholine; Animals; Atropine; Atropine Derivatives; Caffeine; Catecholamines; Cocaine; Male; Methamphetamine; Methyltyrosines; Morphine; Motor Activity; Rats; Scopolamine; Scopolamine Derivatives | 1977 |
[The effect of psychotropic substances on the mental and physical work capacity of rats].
Topics: Amphetamine; Animals; Benactyzine; Caffeine; Chlordiazepoxide; Cocaine; Diazepam; Disability Evaluation; Electric Stimulation; Learning; Male; Meprobamate; Morphine; Phenobarbital; Psychotropic Drugs; Rats; Reinforcement, Psychology; Self Stimulation; Stimulation, Chemical; Work Capacity Evaluation | 1975 |
Effects of certain abused drug s on hemolysin forming cells.
Topics: Amphetamines; Animals; Antibody Formation; Antibody-Producing Cells; Ascorbic Acid; Aspirin; Caffeine; Hemolysin Proteins; Mice; Morphine; Nalorphine; Phenobarbital; Spleen | 1975 |
Drug discrimination studies in rats with caffeine and phenylpropanolamine administered separately and as mixtures.
Topics: Animals; Caffeine; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Generalization, Stimulus; Male; Morphine; Phenylpropanolamine; Rats; Reinforcement, Psychology | 1992 |
Assessment of the ambulation-increasing effect of ketamine by coadministration with central-acting drugs in mice.
Topics: alpha-Methyltyrosine; Animals; Caffeine; Central Nervous System Agents; Central Nervous System Depressants; Ceruletide; Cocaine; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Methamphetamine; Methyltyrosines; Mice; Morphine; Motor Activity; Neurotransmitter Uptake Inhibitors; Nimodipine; Piperazines; Scopolamine | 1992 |
Effects of morphine in the nucleus accumbens on stimulant-induced locomotion.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Caffeine; Central Nervous System Stimulants; Dizocilpine Maleate; Dopamine Agents; Glutamine; Ibotenic Acid; Male; Morphine; Motor Activity; Neural Pathways; Nucleus Accumbens; Oligopeptides; Picrotoxin; Rats; Scopolamine; Synaptic Transmission | 1991 |
An original method for assessment of the jumping test.
Topics: Animals; Behavior, Animal; Caffeine; Guanfacine; Male; Methods; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Substance Withdrawal Syndrome | 1991 |
The effects of cocaine in combination with other drugs of abuse on schedule-controlled behavior in the pigeon.
Topics: Animals; Caffeine; Cocaine; Columbidae; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Illicit Drugs; Male; Morphine; Reinforcement Schedule | 1990 |
Unpleasant and anticonflict effects of nicotine observed by conditioned taste aversion and hypertonic NaCl solution tests in mice.
Topics: Animals; Anti-Anxiety Agents; Caffeine; Conditioning, Psychological; Dose-Response Relationship, Drug; Hypertonic Solutions; Injections, Subcutaneous; Male; Methamphetamine; Mice; Morphine; Nicotine; Sodium Chloride; Taste | 1990 |
The ambulation-increasing effect of buprenorphine in mice: comparison with the effect of morphine.
Topics: Animals; Buprenorphine; Caffeine; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Locomotion; Male; Methamphetamine; Mice; Morphine; Naloxone; Pilocarpine; Scopolamine | 1991 |
[Characteristics of antagonism between ceruletide and various central-acting drugs: investigation by means of ambulatory activity in mice].
Topics: Animals; Bromocriptine; Caffeine; Ceruletide; Cocaine; Dose-Response Relationship, Drug; Drug Tolerance; Ephedrine; Haloperidol; Male; Methamphetamine; Methylphenidate; Mice; Morphine; Motor Activity; Scopolamine | 1990 |
[A new system for the measurement and analysis of motor activity in mice: effect of several central stimulants].
Topics: Animals; Apomorphine; Behavioral Sciences; Caffeine; Cocaine; Dose-Response Relationship, Drug; Male; Methamphetamine; Mice; Morphine; Motor Activity | 1990 |
Effects of psychoactive drugs on the conflict behavior under operant situation in Mongolian gerbils (Meriones unguiculatus).
Topics: Animals; Caffeine; Conditioning, Operant; Conflict, Psychological; Diazepam; Ethanol; Gerbillinae; Male; Morphine; Nicotine; Pentobarbital; Psychotropic Drugs | 1990 |
Effects of some adenosine analogs on morphine-induced analgesia and tolerance.
Topics: 2-Chloroadenosine; Adenosine; Analgesics; Animals; Caffeine; Drug Synergism; Drug Tolerance; Injections, Intraventricular; Mice; Morphine; Naloxone; Phenylisopropyladenosine | 1990 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines | 1986 |
Effects of (-)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice.
Topics: Adenosine; Analgesics; Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Humans; Male; Mice; Morphine; Morphine Dependence; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic | 1985 |
Effects of caffeine and 8-phenyltheophylline on the actions of purines and opiates in the guinea-pig ileum.
Topics: Adenosine; Animals; Caffeine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Nalorphine; Norepinephrine; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1986 |
The effect of chronic administration of caffeine on morphine-induced analgesia, tolerance and dependence in mice.
Topics: Analgesia; Animals; Caffeine; Drug Interactions; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Phenylisopropyladenosine; Reaction Time; Receptors, Opioid | 1986 |
Changes in adenosine receptor sensitivity in morphine-tolerant and -dependent mice.
Topics: Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Motor Activity; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Tritium; Xanthines | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Failure of coffee to inhibit the pharmacodynamic activity of morphine in vivo.
Topics: Analgesia; Animals; Blood Pressure; Caffeine; Coffee; Guinea Pigs; Heart Rate; Male; Mice; Morphine; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains; Respiration | 1986 |
The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats.
Topics: Animals; Body Weight; Caffeine; Drug Interactions; Electroencephalography; Lithium; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains | 1985 |
Potentiation of morphine analgesia by caffeine.
Topics: Analgesia; Animals; Caffeine; Drug Synergism; Male; Morphine; Rats; Rats, Inbred Strains | 1985 |
Morphine--caffeine analgesic interaction in rats.
Topics: Analgesics; Animals; Caffeine; Drug Synergism; Electric Stimulation; Hot Temperature; Male; Morphine; Motor Activity; Pain; Pressure; Rats; Rats, Inbred Strains; Sensory Thresholds; Vocalization, Animal | 1985 |
Effect of - and -adrenergic blocking agents and para-chlorophenylalanine on morphine- and caffeine-stimulated locomotor activity of mice.
Topics: Adrenergic beta-Antagonists; Animals; Caffeine; Drug Antagonism; Ethanolamines; Female; Fenclonine; Locomotion; Male; Mice; Morphine; Motor Activity; Nitrobenzenes; Phenethylamines; Phenoxybenzamine; Propranolol | 1973 |
On the electroencephalogram of man. Thirteenth report.
Topics: Adult; Atropine; Bipolar Disorder; Caffeine; Cerebral Cortex; Cocaine; Electroencephalography; Female; Germany; Heart Rate; History, 20th Century; Humans; Male; Methods; Morphine; Psychophysiology; Pulse; Stimulation, Chemical; Time Factors | 1969 |
[Reaction with drugs of basophilic structures in young red blood cells].
Topics: Animals; Atropine; Caffeine; Guinea Pigs; Heinz Bodies; Microscopy, Electron; Morphine; Organoids; Phenylhydrazines; Quinine; Reticulocytes; Ribosomes | 1967 |
Effect of temperature and drug therapy on anthrax intoxication.
Topics: Adrenocorticotropic Hormone; Animals; Anthrax; Barbiturates; Body Temperature; Caffeine; Hydrocortisone; Immunization, Passive; Morphine; Rats; Stress, Physiological; Temperature; Toxins, Biological | 1967 |
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine | 1966 |
Local vesicle populations in rat superior cervical ganglia and the vesicle hypothesis.
Topics: Action Potentials; Animals; Caffeine; Calcium; Electric Stimulation; Epinephrine; Ganglia, Autonomic; Ganglia, Spinal; In Vitro Techniques; Magnesium; Microscopy, Electron; Morphine; Rats; Synaptic Membranes; Synaptic Transmission; Synaptic Vesicles | 1973 |
A thin-layer chromatographic procedure for the separation of aspirin, cocaine, caffeine, codeine, heroin, 6-monoacetyl morphine, and morphine.
Topics: Aspirin; Caffeine; Chromatography, Thin Layer; Cocaine; Codeine; Gels; Heroin; Methods; Morphinans; Morphine; Silicon Dioxide; Solvents | 1974 |
Potentiation of the anticonvulsant action of acetazolamide.
Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism; Electric Stimulation; Electroshock; Ephedrine; Histamine H1 Antagonists; Imipramine; Isoproterenol; Male; Metaraminol; Mice; Morphine; Phenethylamines; Quaternary Ammonium Compounds; Seizures; Stress, Physiological; Tranylcypromine; Tyramine | 1966 |
[On the inhibitory effect of kinins on isolated intestinal sections].
Topics: Anesthetics, Local; Animals; Atropine; Bradykinin; Caffeine; Duodenum; Ganglionic Blockers; Guanethidine; Ileum; Jejunum; Kallidin; Meperidine; Methadone; Morphine; Phenylbutazone; Rabbits | 1966 |
A quantitative method for continuous recording of spontaneous activity in small animals.
Topics: Animals; Azoles; Behavior, Animal; Caffeine; Central Nervous System; Central Nervous System Stimulants; Dextroamphetamine; Ephedrine; Guinea Pigs; Methamphetamine; Morphine; Motor Activity; Nikethamide; Psychology, Experimental; Rats; Strychnine | 1967 |
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Temperature; Brain Chemistry; Caffeine; Cats; Central Nervous System; Chlordiazepoxide; Chlorpromazine; Drug Synergism; Ethanol; Haplorhini; Indoleacetic Acids; Male; Meprobamate; Methylphenidate; Mice; Morphine; Motor Activity; Pentobarbital; Piperidines; Rats; Reserpine; Respiration; Salivation; Seizures; Serotonin; Triazines | 1970 |
The effects of some psychoactive drugs on rat brain adenosine triphosphate levels.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antidepressive Agents; Aporphines; Brain; Brain Chemistry; Caffeine; Catatonia; Cats; Central Nervous System Stimulants; Fluorometry; Humans; Injections, Intraperitoneal; Injections, Intravenous; Methamphetamine; Methods; Mice; Morphine; Rabbits; Rats; Spectrophotometry; Time Factors | 1970 |
Brain uptake of metabolites and drugs following carotid arterial injections.
Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats | 1971 |
Activation of brain monoamine oxidase by some CNS depressants.
Topics: Animals; Barbiturates; Brain; Caffeine; Cattle; Enzyme Activation; Ethanol; Hypnotics and Sedatives; In Vitro Techniques; Kinetics; Levallorphan; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morphine; Proteins; Reserpine; Secobarbital; Thiopental | 1974 |
Effect of Panax Ginseng root on exhaustive exercise in mice.
Topics: Animals; Caffeine; Deanol; Exploratory Behavior; Fatigue; Glucose; Injections, Intraperitoneal; Male; Methamphetamine; Mice; Morphine; Motor Activity; Panax; Physical Exertion; Plant Extracts; Plants, Medicinal | 1974 |
[Stability of alkaloids in organic solvents. 1].
Topics: Acetone; Alkaloids; Atropine; Benzene; Caffeine; Chloroform; Codeine; Darkness; Drug Stability; Ethanol; Light; Methanol; Morphine; Noscapine; Papaverine; Physostigmine; Pilocarpine; Quinine; Radiation; Reserpine; Scopolamine; Solvents; Temperature; Thebaine | 1972 |
Separation of morphine alkaloids, heroin, methadone and other drugs by ion-exchange chromatography.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Heroin; Methadone; Methods; Morphine; Opium; Phenacetin; Solvents | 1973 |
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cocaine; Codeine; Evaluation Studies as Topic; Glucuronates; Humans; Hydrolysis; Meperidine; Meprobamate; Mescaline; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Naloxone; Pentobarbital; Secobarbital; Substance-Related Disorders | 1974 |
Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer.
Topics: Amino Acid Sequence; Amino Acids; Amyloidosis; Bence Jones Protein; Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Colchicine; Dansyl Compounds; Fluorine; Humans; Immunoglobulin Fragments; Immunoglobulins; Iodine; Macromolecular Substances; Methadone; Models, Structural; Morphine; Nitrobenzenes; Phenanthrolines; Protein Binding; Protein Conformation; Uracil; Vitamin K; X-Ray Diffraction | 1974 |
The use of modified cellulose papers in routine toxicological analysis. 4. Alkaloids.
Topics: Acetates; Alkaloids; Amphetamine; Atropine; Caffeine; Cellulose; Chromatography, Paper; Cocaine; Codeine; Methylcellulose; Morphine; Papaverine; Paper; Physostigmine; Sodium Chloride; Strychnine | 1974 |
Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis.
Topics: Anesthetics; Animals; Avoidance Learning; Caffeine; Chlorpromazine; Dextroamphetamine; Escape Reaction; Hallucinogens; Haloperidol; Haplorhini; Lysergic Acid Diethylamide; Male; Morphine; Parasympatholytics; Pentobarbital; Phencyclidine; Piperidines; Psychopharmacology; Size Perception; Strychnine; Visual Perception | 1967 |
Self-administration of psychoactive substances by the monkey.
Topics: Animals; Behavior, Animal; Caffeine; Catheterization; Chlorpromazine; Cocaine; Codeine; Dextroamphetamine; Ethanol; Haplorhini; Humans; Mescaline; Morphinans; Morphine; Morphine Dependence; Pentobarbital; Substance-Related Disorders | 1969 |
Experimental studies on the effective procedure to inhibit the development of tolerance to and dependence on morphine.
Topics: Analgesia; Animals; Caffeine; Drug Synergism; Drug Tolerance; Haplorhini; Humans; Injections, Subcutaneous; Morphine; Phenothiazines; Rats; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1970 |
Confirmed identification of biotransformed drugs of abuse in urine.
Topics: Amphetamine; Analgesics; Barbiturates; Biotransformation; Caffeine; Cannabis; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Methadone; Morphine; Nicotine; Pharmaceutical Preparations; Procaine; Skin; Spectrum Analysis; Substance-Related Disorders; Tranquilizing Agents | 1972 |
4-Dimethyl-amino methyl-2-methyl 1,3 dioxolane--a new potent analgesic agent.
Topics: Analgesics; Animals; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Dioxoles; Electric Stimulation; Meperidine; Mice; Morphine; Pain; Phenacetin; Quinones; Stimulation, Chemical | 1969 |
[Action of some stimulants and depressants on simple extinction].
Topics: Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Classical; Extinction, Psychological; Meprobamate; Morphine; Motivation; Pentobarbital; Psychopharmacology; Rats | 1970 |
[Intraspecific aggressive behavior induced by apomorphine in the rat].
Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine | 1970 |
The effect of thyroid hormones on the action of some centrally acting drugs.
Topics: Analgesia; Animals; Caffeine; Castration; Dextroamphetamine; Drug Synergism; Ethinyl Estradiol; Hexobarbital; Male; Mice; Morphine; Motor Activity; Rats; Sex Factors; Sleep; Thyroidectomy; Thyroxine; Time Factors | 1970 |
Neuropharmacological properties of Su17595A a chlorpromazine-like central nervous system depressant.
Topics: Animals; Blood Pressure; Brain Stem; Caffeine; Cats; Chlordiazepoxide; Chlorpromazine; Cocaine; Depression, Chemical; Dextroamphetamine; Drug Antagonism; Hypnotics and Sedatives; Male; Mice; Morphine; Morpholines; Motor Activity; Pentylenetetrazole; Piperazines; Propiophenones; Rats; Reflex; Respiration; Seizures; Strychnine; Tranquilizing Agents | 1971 |
[Detection of drugs in knee joint synovia].
Topics: Albumins; Aspirin; Binding Sites; Biological Transport; Caffeine; Chlorpromazine; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Diazepam; Ephedrine; Forensic Medicine; Humans; Knee Joint; Meprobamate; Methods; Molecular Weight; Morphine; Phenacetin; Phenylbutazone; Procaine; Synovial Fluid; Synovial Membrane | 1971 |
Osmotic properties of aqueous solutions containing caffeine.
Topics: Aminobenzoates; Benzoates; Caffeine; Citrates; Mathematics; Methods; Morphine; Osmosis; Papaverine; Salicylates | 1968 |
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental | 1968 |
[The effect of certain emergency drugs on intramuscular tension of skeletal muscles as an important factor of extracardiac circulation].
Topics: Analgesics; Atropine; Blood Circulation; Caffeine; Ephedrine; Epinephrine; First Aid; Morphine; Muscle Relaxants, Central; Muscles; Neostigmine; Nikethamide; Piperidines; Strychnine | 1968 |
[On the status of some trace elements in the kidneys with function of changes of the central nervous system].
Topics: Aluminum; Anesthesia, General; Animals; Caffeine; Central Nervous System; Copper; Ethyl Ethers; Kidney; Manganese; Morphine; Silicon; Titanium | 1965 |
Gas-liquid chromatography of submicrogram amounts of drugs. I. Preparation, scope and limitation of columns.
Topics: Acetaminophen; Amphetamine; Caffeine; Chlordiazepoxide; Chromatography, Gas; Cyclizine; Morphine; Phenelzine; Phenylbutazone; Salicylates; Scopolamine; Secobarbital; Trifluoperazine | 1966 |
Experimental observations on the pharmacology of the pontine respiration center.
Topics: Animals; Caffeine; Cats; Chlorpromazine; Morphine; Pentobarbital; Pentylenetetrazole; Piperidines; Respiration; Reticular Formation; Urethane | 1967 |
Inhibition of evoked potentials by caudate stimulation and its antagonism by centrally acting drugs.
Topics: Amphetamine; Amygdala; Animals; Bemegride; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electrophysiology; Evoked Potentials; Forelimb; Hippocampus; Hypothalamus; Imipramine; Medulla Oblongata; Mephenesin; Morphine; Neurons; Pentobarbital; Pentylenetetrazole; Picrotoxin; Reticular Formation; Strychnine; Thalamus | 1967 |
Purine involvement in morphine antinociception.
Topics: 2-Chloroadenosine; Adenosine; Analgesia; Animals; Body Temperature; Bucladesine; Caffeine; Male; Morphine; Phenylisopropyladenosine; Rats; Rats, Inbred Strains | 1984 |
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.
Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rats; Theophylline; Xanthines | 1983 |
Unique influences of ten drugs upon post-shock biting attack and pre-shock manual responding.
Topics: Aggression; Animals; Bites and Stings; Caffeine; Chlordiazepoxide; Chlorpromazine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diazepam; Electroshock; Ethanol; Female; Humans; Male; Morphine; Nicotine; Phenobarbital; Saimiri | 1983 |
[Effect of methamphetamine on morphine preference].
Topics: Animals; Caffeine; Choice Behavior; Cocaine; Drug Combinations; Humans; Male; Methamphetamine; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Taste | 1983 |
Pentobarbital antagonizes the effect of morphine on cardiac acceleration response to noxious stimulation.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Heart Rate; Male; Morphine; Pentobarbital; Physical Stimulation; Rats; Rats, Inbred Strains | 1984 |
Sensitivity changes after morphine treatment in the mouse uterus.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Drug Tolerance; Female; In Vitro Techniques; Mice; Morphine; Naloxone; Serotonin; Theophylline; Uterine Contraction | 1982 |
Analgesic drugs in breast milk and plasma.
Topics: Acetaminophen; Adult; Analgesics; Caffeine; Codeine; Female; Humans; Kinetics; Milk, Human; Morphine; Phenacetin; Salicylates | 1981 |
Effects of morphine and caffeine on adenosine release from rat cerebral cortex: is caffeine a morphine antagonist.
Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Male; Morphine; Rats; Tritium | 1980 |
Drug discrimination analysis of midazolam under a three-lever procedure: I. Dose-dependent differences in generalization and antagonism.
Topics: Animals; Caffeine; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Methocarbamol; Midazolam; Morphine; Pentobarbital; Rats; Rats, Sprague-Dawley | 1995 |
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Microsomes; Morphine; Nimodipine; omega-Conotoxin GVIA; Pain; Peptides; Ryanodine; Terpenes; Thapsigargin | 1995 |
A device for automatic measurement of writhing and its application to the assessment of analgesic agents.
Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Electric Stimulation; Inflammation; Injections, Subcutaneous; Male; Mefenamic Acid; Mice; Morphine; Pain; Pain Measurement; Time Factors; Transducers | 1994 |
Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.
Topics: Animals; Avoidance Learning; Caffeine; Chlorpromazine; Diazepam; Electroshock; Imipramine; Male; Mice; Morphine; Nicotine; Psychotropic Drugs; Signal Detection, Psychological | 1994 |
Interactions of opioids with caffeine: evaluation by ambulatory activity in mice.
Topics: Animals; Behavior, Animal; Buprenorphine; Caffeine; Dopamine Antagonists; Drug Interactions; Mice; Mice, Inbred Strains; Morphine; Narcotics; Pentazocine | 1994 |
Impurities, adulterants and diluents of illicit heroin. Changes during a 12-year period.
Topics: Acetaminophen; Caffeine; Carbohydrates; Denmark; Drug Contamination; Heroin; Hydrogen-Ion Concentration; Illicit Drugs; Lactose; Morphine; Noscapine; Papaverine; Phenobarbital; Procaine | 1994 |
Restraint stress potentiates analgesia induced by 5'-N-ethylcarboxamidoadenosine: comparison with morphine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Restraint, Physical; Stress, Physiological | 1993 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; Dose-Response Relationship, Drug; Drug Tolerance; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Morphine; Pentobarbital; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Stimulation, Chemical | 1993 |
Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels. 1. Polymer composition.
Topics: Aminophylline; Biocompatible Materials; Caffeine; Diffusion; Drug Carriers; Drug Delivery Systems; Gels; Models, Chemical; Morphine; Polyethylene Glycols; Polyurethanes; Solubility; Theophylline; Water | 1993 |
Determination of morphine analogues, caffeine and amphetamine in biological fluids by capillary electrophoresis with the marker technique.
Topics: Amphetamine; Body Fluids; Caffeine; Cannabinoids; Codeine; Electrochemistry; Electrophoresis, Capillary; Heroin; Humans; Kinetics; Micelles; Morphine; Morphine Derivatives | 1996 |
[The effects of caffeine on the respiratory depression by morphine].
Topics: Analgesics, Opioid; Animals; Caffeine; Depression, Chemical; Morphine; Rats; Respiration; Respiratory Insufficiency | 1997 |
Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin.
Topics: Analysis of Variance; Animals; beta-Endorphin; Caffeine; Electroshock; Lithium Chloride; Male; Morphine; Oscillometry; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Kinase; Animals; Body Weight; Caffeine; Deoxyadenosines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Morphine; Receptors, Purinergic P1; Substance Withdrawal Syndrome | 1998 |
Involvement of intracellular calcium in morphine tolerance in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Biological Transport; Caffeine; Calcium; Calcium Channels; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Male; Mice; Microsomes; Morphine | 1999 |
Adenosine receptor antagonists inhibit the development of morphine sensitization in the C57BL/6 mouse.
Topics: Adenosine; Animals; Caffeine; Drug Combinations; Drug Resistance; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Narcotics; Purinergic P1 Receptor Antagonists; Xanthines | 1999 |
Cocaine-seeking produced by experimenter-administered drug injections: dose-effect relationships in rats.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Male; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule | 1999 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures | 2000 |
Comparison of drug effects on the performance of two timing tasks in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pentobarbital; Physostigmine; Rats; Rats, Sprague-Dawley; Task Performance and Analysis; Time Factors | 2000 |
Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats.
Topics: Adenosine; Analgesics, Opioid; Animals; Caffeine; Electrophysiology; Male; Medulla Oblongata; Microinjections; Morphine; Morphine Dependence; Neurons; Purinergic P1 Receptor Agonists; Rats; Substance Withdrawal Syndrome; Theophylline | 2001 |
Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro.
Topics: Administration, Cutaneous; Animals; Buffers; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Excipients; In Vitro Techniques; Male; Mice; Mice, Hairless; Morphine; Narcotics; Propylene Glycols; Skin Absorption; Stimulation, Chemical; Surface-Active Agents; Ultrasonics | 2001 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug Combinations; Hyperalgesia; Indomethacin; Male; Mice; Migraine Disorders; Morphine; Prochlorperazine; Substance Withdrawal Syndrome; Time Factors | 2002 |
Effects of acute and chronic caffeine intake on intravenous self-administration of morphine in two rat strains.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Feeding Behavior; Male; Morphine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Self Administration; Species Specificity; Time Factors | 2002 |
Effect of social isolation on behavioral parameters and sensitivity of rats to morphine and caffeine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Depression; Male; Morphine; Psychomotor Agitation; Rats; Social Isolation | 2003 |
Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.
Topics: Animals; Atomoxetine Hydrochloride; Attention; Caffeine; Cognition; Cognition Disorders; Color Perception; Female; Macaca mulatta; Macaca nemestrina; Male; Methylphenidate; Morphine; Neuropsychological Tests; Nicotine; Nomifensine; Photic Stimulation; Propylamines; Substance-Related Disorders; Task Performance and Analysis | 2003 |
The modulatory actions of dopamine D2/3 agonists and antagonists on the locomotor-activating effects of morphine and caffeine in mice.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Mice; Morphine; Motor Activity; Naphthalenes; Narcotic Antagonists; Narcotics; Pyrrolidines; Quinolines; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Water | 2003 |
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles | 2003 |
Retention of sequential drug discriminations under fixed-interval schedules for long time periods without training.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Chlordiazepoxide; Cocaine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Generalization, Psychological; Male; Morphine; Nicotine; Pentobarbital; Reinforcement Schedule | 2003 |
[Endoarterial antihistaminics; effect on reactivity to adrenalin, histamine, caffeine, and morphine. II..].
Topics: Anti-Allergic Agents; Caffeine; Epinephrine; Histamine; Histamine H1 Antagonists; Humans; Morphine; Skin | 1953 |
[Comparative studies in psychopharmacologic exploration with special regard to the use of barbiturates with other drugs (amphetamine, coramine, caffeine, morphine)].
Topics: Amphetamine; Amphetamines; Barbiturates; Caffeine; Morphine; Nikethamide | 1953 |
Neurological agents in child psychiatry.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Caffeine; Child; Child Psychiatry; Humans; Morphine; Neostigmine; Pain; Pain Management | 1957 |
[The effect of various pharmacological agents (amphetamine, cocaine, caffeine, hexobarbital, meprobamate, morphine, dextromoramide, 1-methadone, pethidine and CT 3570) on the time of exhaustion and behavior of animals swimming at 20 degrees C].
Topics: Amphetamine; Amphetamines; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Behavior; Caffeine; Central Nervous System Stimulants; Cocaine; Dextromoramide; Hexobarbital; Hypnotics and Sedatives; Meperidine; Meprobamate; Methadone; Morphine; Physical Exertion; Swimming; Tomography, X-Ray Computed | 1960 |
Antagonism by caffeine of the respiratory effects of codeine and morphine.
Topics: Caffeine; Cell Respiration; Codeine; Humans; Morphine; Respiration | 1962 |
Course of some pharmacological tests in functionally decorticated animals.
Topics: Amphetamine; Amphetamines; Animals; Caffeine; Cerebral Cortex; Cerebral Decortication; Chlorpromazine; Ethers; Magnesium Sulfate; Meperidine; Morphine; Pentylenetetrazole; Phenylbutazone; Pregnanediones; Strychnine; Thiopental | 1963 |
The addiction potential of oxycodone (Percodan).
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Behavior, Addictive; Caffeine; California; Drug Combinations; Humans; Morphine; Oxycodone; Phenacetin | 1963 |
Drugs that modify actions of pharmacologically active polypeptides.
Topics: Atropine; Bradykinin; Caffeine; Chlorpromazine; Dibucaine; Ergot Alkaloids; Humans; Hypertension; Lysergic Acid Diethylamide; Morphine; Oxytocin; Peptides; Phenoxybenzamine; Reserpine; Tripelennamine; Vasopressins; Vitamin B 12 | 1963 |
RELATIONSHIP BETWEEN CHOLINERGIC DRUGS AND EEG ACTIVATION.
Topics: Atropine; Bemegride; Caffeine; Chlordiazepoxide; Chlorpromazine; Cholinergic Agents; Dextroamphetamine; Electroencephalography; Lysergic Acid Diethylamide; Methylphenidate; Morphine; Parasympathomimetics; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenoxybenzamine; Physostigmine; Rabbits; Research | 1963 |
[EFFECT OF SEMEN ZIZYPHI AND FRUCTUS SCHIZANDRAE ON EXPERIMENTAL BURN].
Topics: Animals; Bromides; Burns; Caffeine; Edema; Mice; Morphine; Pharmacology; Plants, Medicinal; Rats; Research; Schisandra; Seeds; Shock, Septic | 1963 |
INTERACTION OF CAFFEINE AND MORPHINE ON RESPIRATION.
Topics: Biomedical Research; Caffeine; Cell Respiration; Morphine; Pharmacology; Respiration; Respiratory Function Tests | 1964 |
[ON A NEW METHOD OF RECORDING MOVEMENT IN THE LABORATORY ANIMAL MAINTAINED IN ITS REARING ENVIRONMENT--ITS APPLICATION TO THE STUDY OF SOME BEHAVIOR-MODIFYING AGENTS].
Topics: Amphetamine; Amphetamines; Animals; Animals, Laboratory; Barbiturates; Behavior, Animal; Caffeine; Chlorpromazine; Cinnamates; Cyanides; Heterocyclic Compounds; Hypnotics and Sedatives; Injections, Intraperitoneal; Mice; Morphine; Movement; Pharmacology; Phenobarbital; Research; Reserpine | 1964 |
Antinociceptive effects of novel A2B adenosine receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analgesia; Animals; Caffeine; Drug Synergism; Male; Mice; Morphine; Pain | 2004 |
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzazepines; Brain; Caffeine; Central Nervous System Stimulants; Cocaine; Desipramine; Dopamine Antagonists; Dronabinol; Enzyme Activation; Fluoxetine; Immunohistochemistry; Male; Mice; Mitogen-Activated Protein Kinases; Morphine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Scopolamine; Selective Serotonin Reuptake Inhibitors | 2004 |
Effect of chronic caffeine consumption on changes in locomotor activity of WAG/G and Fischer-344 rats induced by nicotine, ethanol, and morphine.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Caffeine; Feeding Behavior; Male; Morphine; Motor Activity; Nicotine; Rats; Rats, Inbred F344; Rats, Inbred Strains | 2003 |
Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice.
Topics: Amphetamine; Animals; Benzazepines; beta-Endorphin; Caffeine; Environment; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Morphine; Motor Activity; Naltrexone; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 2005 |
Morphine reward in dopamine-deficient mice.
Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Mice; Morphine; Motor Activity; Pain; Pain Threshold; Reward; Tail; Tyrosine 3-Monooxygenase | 2005 |
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Corpus Striatum; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Exploratory Behavior; Male; Mice; Mice, Knockout; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Receptor, Adenosine A2A; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Effect of caffeine and morphine on the developing pre-mature brain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Caffeine; Cell Count; Central Nervous System Stimulants; Female; Fluoresceins; Male; Morphine; Narcotics; Neurons; Organic Chemicals; Pregnancy; Random Allocation; Rats; Rats, Long-Evans; Time Factors | 2008 |
Nails of newborns in monitoring drug exposure during pregnancy.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine; Nails; Narcotics; Nicotine; Nicotinic Agonists; Pregnancy; Smoking | 2008 |
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analgesics, Opioid; Animals; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Phenethylamines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinidine; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P2; Substance Withdrawal Syndrome; Theobromine; Theophylline | 2009 |
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Benzene Derivatives; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain; Pain Measurement | 2009 |
Modeling withdrawal syndrome in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Ethanol; Exploratory Behavior; Female; Hydrocortisone; Male; Morphine; Substance Withdrawal Syndrome; Time Factors; Zebrafish | 2010 |
Gas chromatographic method validation for the analysis of major components in illicit heroin seized in Malaysia.
Topics: Acetaminophen; Caffeine; Chromatography, Gas; Codeine; Dextromethorphan; Heroin; Malaysia; Morphine; Morphine Derivatives; Reproducibility of Results | 2012 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body | 2013 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; Fenclonine; Hyperalgesia; Male; Mice; Morphine; Pain, Postoperative; Receptor, Adenosine A1; Xanthines; Yohimbine | 2013 |
Quantification of five compounds with heterogeneous physicochemical properties (morphine, 6-monoacetylmorphine, cyamemazine, meprobamate and caffeine) in 11 fluids and tissues, using automated solid-phase extraction and gas chromatography-tandem mass spec
Topics: Caffeine; Gas Chromatography-Mass Spectrometry; Limit of Detection; Meprobamate; Morphine; Morphine Derivatives; Phenothiazines; Solid Phase Extraction; Tandem Mass Spectrometry | 2014 |
Blockade of phosphodiesterase 4 reverses morphine-induced ventilatory disturbance without loss of analgesia.
Topics: Analgesics, Opioid; Animals; Caffeine; Male; Morphine; Pain Measurement; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Phrenic Nerve; Rats; Rats, Wistar; Respiration Disorders; Respiratory Mechanics; Rolipram; Vagotomy | 2015 |
Possible mechanism for inhibition of morphine formation from 6-acetylmorphine after intake of street heroin.
Topics: Caffeine; Carboxylesterase; Central Nervous System Depressants; Central Nervous System Stimulants; Chromatography, Liquid; Ethanol; Forensic Toxicology; Heroin Dependence; Humans; Liver; Mass Spectrometry; Morphine; Morphine Derivatives; Narcotics; Salicylic Acid; Thebaine | 2015 |
Activation of adenosine A₂A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amphetamine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Interpersonal Relations; Male; Morphine; Motivation; Motor Activity; Narcotics; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reward; Social Behavior; Vocalization, Animal | 2016 |
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine | 2016 |
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Disease; Corticosterone; Electroencephalography; Electromyography; Female; Hyperalgesia; Ibuprofen; Male; Mice; Modafinil; Morphine; Pain; Pain Threshold; Sleep Deprivation; Wakefulness; Wakefulness-Promoting Agents | 2017 |
Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.
Topics: Analgesics, Opioid; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Female; Illicit Drugs; Lithium Chloride; Male; Morphine; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Reinforcement, Psychology; Taste | 2019 |
Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Nicotine; Nicotinic Agonists; Pregnancy; Smoking | 1998 |