caffeine and metronidazole

caffeine has been researched along with metronidazole in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's5 (18.52)18.2507
2000's9 (33.33)29.6817
2010's11 (40.74)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Fujiwara, H; Kai, J; Masuda, T; Nakamura, K; Ueda, I1
Topliss, JG; Yoshida, F1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dudley, MN; Marchbanks, CR; Radandt, JM1
Lyall, JB1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Weiss, M1
Rudenko, IIa; Vartanian, LP; Volchkov, VA1
Chen, H; Sun, N; Wu, B; Ye, Y; Zhang, T1
Adedayo, O; Adeoye-Isijola, MO; Coopoosamy, RM; Okon, V; Olajuyigbe, OO1
Coboeken, K; Dallmann, A; Eissing, T; Hempel, G; Ince, I1
Chen, L; Fang, J; Guo, K; Hou, S; Kong, X; Meng, F; Shang, C; Wu, Z; Xiao, H; Yang, X1
Lindahl, E; Lundborg, M; Norlén, L; Wennberg, C1

Reviews

2 review(s) available for caffeine and metronidazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 14, Issue:1

    Topics: Absorption; Antacids; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interactions; Food; Humans; Metronidazole; Theophylline

1992

Trials

1 trial(s) available for caffeine and metronidazole

ArticleYear
Third molar surgery: the effect of primary closure, wound dressing and metronidazole on postoperative recovery.
    Journal of the Royal Army Medical Corps, 1991, Volume: 137, Issue:2

    Topics: Acetaminophen; Adult; Analgesics; Bandages; Bismuth; Caffeine; Codeine; Drug Combinations; Female; Humans; Hydrocarbons, Iodinated; Male; Metronidazole; Molar, Third; Pain, Postoperative; Surgical Wound Infection; Suture Techniques; Sutures; Tooth, Impacted; Wound Healing

1991

Other Studies

24 other study(ies) available for caffeine and metronidazole

ArticleYear
Thermodynamic aspects of hydrophobicity and the blood-brain barrier permeability studied with a gel filtration chromatography.
    Journal of medicinal chemistry, 1996, Jun-21, Volume: 39, Issue:13

    Topics: Blood-Brain Barrier; Chromatography, Gel; Hydrogen Bonding; Micelles; Permeability; Solubility; Thermodynamics

1996
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogPoct: a tool for lipophilicity determination in drug discovery.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
    Clinical pharmacokinetics, 1990, Volume: 18, Issue:5

    Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Ketanserin; Lidocaine; Liver Diseases; Metronidazole; Nomifensine; Triamterene

1990
[The radiation therapy of experimental brain tumors by using the radiosensitizing preparation xanthobin (8-bromocaffeine)].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:11

    Topics: Animals; Brain Neoplasms; Caffeine; Drug Evaluation, Preclinical; Glioma; Metronidazole; Neoplasm Transplantation; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats

1989
Sorption and degradation of wastewater-associated pharmaceuticals and personal care products in agricultural soils and sediment.
    Water science and technology : a journal of the International Association on Water Pollution Research, 2013, Volume: 68, Issue:5

    Topics: Adsorption; Caffeine; China; Chloramphenicol; Environmental Monitoring; Geologic Sediments; Metronidazole; Rivers; Soil Pollutants; Tinidazole; Water Pollutants, Chemical

2013
In vitro pharmacological interaction of caffeine and first-line antibiotics is antagonistic against clinically important bacterial pathogens.
    Acta biochimica Polonica, 2017, Volume: 64, Issue:2

    Topics: Anti-Bacterial Agents; Bacteria; Caffeine; Chloramphenicol; Drug Synergism; Erythromycin; Humans; Kanamycin; Metronidazole; Microbial Sensitivity Tests; Nalidixic Acid; Tetracycline

2017
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
    Clinical pharmacokinetics, 2018, Volume: 57, Issue:6

    Topics: Caffeine; Cytochrome P-450 Enzyme System; Diazepam; Female; Granisetron; Humans; Metoprolol; Metronidazole; Midazolam; Models, Biological; Nifedipine; Ondansetron; Pharmaceutical Preparations; Pregnancy

2018
Factors affecting the roles of reactive species in the degradation of micropollutants by the UV/chlorine process.
    Water research, 2017, 12-01, Volume: 126

    Topics: Ammonia; Anti-Infective Agents; Bicarbonates; Caffeine; Chlorides; Chlorine; DEET; Free Radical Scavengers; Halogenation; Hydrogen-Ion Concentration; Hydroxyl Radical; Kinetics; Metronidazole; Nalidixic Acid; Oxidation-Reduction; Ultraviolet Rays; Water; Water Pollutants, Chemical; Water Purification

2017
Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations.
    Journal of chemical information and modeling, 2023, 08-14, Volume: 63, Issue:15

    Topics: Caffeine; Metronidazole; Molecular Dynamics Simulation; Naproxen; Permeability; Skin; Skin Absorption; Water

2023