caffeine and methotrexate

caffeine has been researched along with methotrexate in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19905 (11.36)18.7374
1990's4 (9.09)18.2507
2000's16 (36.36)29.6817
2010's18 (40.91)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Jolivette, LJ; Ward, KW1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Luzzio, FA; Monsen, PJ1
Henderson, JF; Lowe, JK1
Baba, H; Tomita, K; Tsuchiya, H; Ueda, Y; Yasutake, H; Yokogawa, A1
Greene, JA; Kavlock, RJ; Kimmel, GL; Morrissey, RE; Owens, E; Rogers, JM; Sadler, TW; Stack, HF; Waters, MD; Welsch, F1
Gołos, B; Malec, J1
Ledbetter, DH; Nussbaum, RL1
Inman, RB1
Fox, M; McMillan, S1
Tomita, K; Tsubota, S; Tsuchiya, H1
Lialiaris, T; Maskaleris, T; Triantaphyllidis, C1
Cronstein, BN; Desai, A; McCrary, CT; Montesinos, MC; Posadas, I; Yap, JS1
Mates, M; Nesher, G; Zevin, S1
Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H1
Benito-Garcia, E; Bilics, JA; Chibnik, LB; Heller, JE; Maher, NE; Matthews, HM; Shadick, NA; Weinblatt, ME1
Barnes, SA; el-Azhary, RA; Mengden Koon, SJ; Swanson, DL1
Chou, PP; Mendu, DR; Soldin, SJ1
Cronstein, B; Haskó, G1
Bergdahl, E; Sundqvist, KG; Talme, T1
Malaviya, AN1
Delavenne, X; Forest, V; He, Z; Hodin, S; Mismetti, P; Perek, N; Puech, C1
Gaber, M; Ghareeb, D; Hamed, A; Hamed, M; Mohamed, TM; Nofal, MS1

Reviews

3 review(s) available for caffeine and methotrexate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Fragile X syndrome: a unique mutation in man.
    Annual review of genetics, 1986, Volume: 20

    Topics: Caffeine; Chromosome Fragility; Female; Fragile X Syndrome; Genetic Counseling; Genetic Linkage; Genetic Markers; Heterozygote; Humans; Hybrid Cells; Intellectual Disability; Male; Methotrexate; Models, Genetic; Pedigree; Phenotype; Sex Chromosome Aberrations; Thymidine

1986
Methylxanthines and inflammatory cells.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theophylline

2011

Trials

2 trial(s) available for caffeine and methotrexate

ArticleYear
Effect of chemotherapy combined with caffeine for osteosarcoma.
    Journal of cancer research and clinical oncology, 1992, Volume: 118, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Calcaneus; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Salvage Therapy; Tibia

1992
Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis.
    The Journal of rheumatology, 2006, Volume: 33, Issue:7

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Central Nervous System Stimulants; Cohort Studies; Diet; Drug Interactions; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Surveys and Questionnaires

2006

Other Studies

39 other study(ies) available for caffeine and methotrexate

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba.
    Journal of natural products, 2018, 08-24, Volume: 81, Issue:8

    Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Asimina; Capillaries; Fruit; Furans; In Vitro Techniques; Lactones; Molecular Structure; Plant Extracts; Rats; Seeds; Structure-Activity Relationship

2018
Enhancement by caffeine of the growth inhibitory effects of antimetabolites in lymphoma L5178Y cells.
    Biochemical pharmacology, 1977, Aug-15, Volume: 26, Issue:16

    Topics: Antimetabolites; Caffeine; Cell Division; Cells, Cultured; Deoxyadenosines; Drug Synergism; Hydroxyurea; In Vitro Techniques; Lymphoma; Methotrexate; Methylthioinosine; Mycophenolic Acid; Neoplasms, Experimental; Time Factors

1977
Activity profiles of developmental toxicity: design considerations and pilot implementation.
    Teratology, 1991, Volume: 43, Issue:2

    Topics: Animals; Biological Assay; Caffeine; Cyclophosphamide; Data Collection; Databases, Factual; Embryonic and Fetal Development; Ethylenethiourea; Humans; Hydroxyurea; Methotrexate; Mutagenicity Tests; Toxicology

1991
Enhancement of methotrexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178Y cells by the reduction of DNA repair efficiency.
    Biochemical pharmacology, 1989, Jun-01, Volume: 38, Issue:11

    Topics: Animals; Caffeine; Cell Division; Cell Survival; DNA; DNA Damage; DNA Repair; Drug Synergism; In Vitro Techniques; Leukemia L5178; Methotrexate; Mice; Tumor Cells, Cultured

1989
Methodology for the study of the effect of drugs on development and DNA replication in Drosophila melanogaster embryonic tissue.
    Biochimica et biophysica acta, 1984, Dec-14, Volume: 783, Issue:3

    Topics: Animals; Caffeine; Cell Membrane Permeability; Cell Nucleus; Colchicine; DNA Replication; Drosophila melanogaster; Embryo, Nonmammalian; Female; Floxuridine; Kinetics; Methotrexate; Microscopy, Electron; Oviposition; Ovum

1984
Effects of metabolic inhibitors on cell lethality and mutation induction in Chinese hamster cells. I. Inhibitors of de novo purine synthesis and a comparison with the effects of caffeine.
    Chemico-biological interactions, 1981, Volume: 36, Issue:1

    Topics: Animals; Azaserine; Caffeine; Cell Line; Cricetinae; Cricetulus; Ethyl Methanesulfonate; Lung; Methotrexate; Methylthioinosine; Mutation; Purines; Ultraviolet Rays

1981
[Chemotherapy for Ewing's sarcoma, malignant fibrous histiocytoma and malignant lymphoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:13

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; Doxorubicin; Histiocytoma, Benign Fibrous; Humans; Lymphoma; Male; Methotrexate; Sarcoma, Ewing

1993
Induction of cytogenetic damage in human lymphocytes in vitro and of antineoplastic effects in Ehrlich ascites tumor cells in vivo treated by methotrexate, hyperthermia and/or caffeine.
    Mutation research, 1998, Dec-03, Volume: 422, Issue:2

    Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Body Weight; Caffeine; Carcinoma, Ehrlich Tumor; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Fever; Humans; Lymphocytes; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Sister Chromatid Exchange; Survival Rate

1998
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant
    Arthritis and rheumatism, 2000, Volume: 43, Issue:3

    Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Experimental; Arthrography; Caffeine; Female; Methotrexate; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Lew; Theophylline

2000
Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:2

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Coffee; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Phosphodiesterase Inhibitors

2003
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
    British journal of pharmacology, 2006, Volume: 148, Issue:8

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles

2006
Caffeine consumption and methotrexate dosing requirement in psoriasis and psoriatic arthritis.
    International journal of dermatology, 2007, Volume: 46, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Psoriatic; Caffeine; Dermatologic Agents; Drug Interactions; Female; Food-Drug Interactions; Humans; Male; Methotrexate; Middle Aged; Psoriasis

2007
An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring Dimension RxL Max clinical chemistry system.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:5

    Topics: Amikacin; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Caffeine; Central Nervous System Stimulants; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Humans; Methotrexate; Sensitivity and Specificity

2007
Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
    European journal of immunology, 2016, Volume: 46, Issue:5

    Topics: Caffeine; Cytokines; Gene Expression Regulation; Gene Silencing; Humans; Immunosuppressive Agents; Low Density Lipoprotein Receptor-Related Protein-1; Methotrexate; Mitogens; RNA, Small Interfering; T-Lymphocytes; Theophylline; Thrombospondin 1

2016
Methotrexate intolerance in the treatment of rheumatoid arthritis (RA): effect of adding caffeine to the management regimen.
    Clinical rheumatology, 2017, Volume: 36, Issue:2

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Chocolate; Coffee; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; India; Male; Methotrexate; Middle Aged; Treatment Outcome; Xanthines

2017
Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies.
    International journal of pharmaceutics, 2018, Nov-15, Volume: 551, Issue:1-2

    Topics: Astrocytes; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Caffeine; Cell Line; Culture Media, Conditioned; Endothelial Cells; Humans; Methotrexate; Rivaroxaban

2018
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.
    BMC complementary medicine and therapies, 2023, Oct-27, Volume: 23, Issue:1

    Topics: Adenosine; Caffeine; Chitosan; Folic Acid; Humans; Immunotherapy; Methotrexate; Molecular Docking Simulation; Nanoparticles; Neoplasms; Receptor, Adenosine A2A; Tumor Microenvironment

2023