caffeine has been researched along with methotrexate in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (11.36) | 18.7374 |
| 1990's | 4 (9.09) | 18.2507 |
| 2000's | 16 (36.36) | 29.6817 |
| 2010's | 18 (40.91) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Luzzio, FA; Monsen, PJ | 1 |
| Henderson, JF; Lowe, JK | 1 |
| Baba, H; Tomita, K; Tsuchiya, H; Ueda, Y; Yasutake, H; Yokogawa, A | 1 |
| Greene, JA; Kavlock, RJ; Kimmel, GL; Morrissey, RE; Owens, E; Rogers, JM; Sadler, TW; Stack, HF; Waters, MD; Welsch, F | 1 |
| Gołos, B; Malec, J | 1 |
| Ledbetter, DH; Nussbaum, RL | 1 |
| Inman, RB | 1 |
| Fox, M; McMillan, S | 1 |
| Tomita, K; Tsubota, S; Tsuchiya, H | 1 |
| Lialiaris, T; Maskaleris, T; Triantaphyllidis, C | 1 |
| Cronstein, BN; Desai, A; McCrary, CT; Montesinos, MC; Posadas, I; Yap, JS | 1 |
| Mates, M; Nesher, G; Zevin, S | 1 |
| Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H | 1 |
| Benito-Garcia, E; Bilics, JA; Chibnik, LB; Heller, JE; Maher, NE; Matthews, HM; Shadick, NA; Weinblatt, ME | 1 |
| Barnes, SA; el-Azhary, RA; Mengden Koon, SJ; Swanson, DL | 1 |
| Chou, PP; Mendu, DR; Soldin, SJ | 1 |
| Cronstein, B; Haskó, G | 1 |
| Bergdahl, E; Sundqvist, KG; Talme, T | 1 |
| Malaviya, AN | 1 |
| Delavenne, X; Forest, V; He, Z; Hodin, S; Mismetti, P; Perek, N; Puech, C | 1 |
| Gaber, M; Ghareeb, D; Hamed, A; Hamed, M; Mohamed, TM; Nofal, MS | 1 |
3 review(s) available for caffeine and methotrexate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Fragile X syndrome: a unique mutation in man.
Topics: Caffeine; Chromosome Fragility; Female; Fragile X Syndrome; Genetic Counseling; Genetic Linkage; Genetic Markers; Heterozygote; Humans; Hybrid Cells; Intellectual Disability; Male; Methotrexate; Models, Genetic; Pedigree; Phenotype; Sex Chromosome Aberrations; Thymidine | 1986 |
Methylxanthines and inflammatory cells.
Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theophylline | 2011 |
2 trial(s) available for caffeine and methotrexate
| Article | Year |
|---|---|
Effect of chemotherapy combined with caffeine for osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Calcaneus; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Salvage Therapy; Tibia | 1992 |
Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Central Nervous System Stimulants; Cohort Studies; Diet; Drug Interactions; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Surveys and Questionnaires | 2006 |
39 other study(ies) available for caffeine and methotrexate
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Asimina; Capillaries; Fruit; Furans; In Vitro Techniques; Lactones; Molecular Structure; Plant Extracts; Rats; Seeds; Structure-Activity Relationship | 2018 |
Enhancement by caffeine of the growth inhibitory effects of antimetabolites in lymphoma L5178Y cells.
Topics: Antimetabolites; Caffeine; Cell Division; Cells, Cultured; Deoxyadenosines; Drug Synergism; Hydroxyurea; In Vitro Techniques; Lymphoma; Methotrexate; Methylthioinosine; Mycophenolic Acid; Neoplasms, Experimental; Time Factors | 1977 |
Activity profiles of developmental toxicity: design considerations and pilot implementation.
Topics: Animals; Biological Assay; Caffeine; Cyclophosphamide; Data Collection; Databases, Factual; Embryonic and Fetal Development; Ethylenethiourea; Humans; Hydroxyurea; Methotrexate; Mutagenicity Tests; Toxicology | 1991 |
Enhancement of methotrexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178Y cells by the reduction of DNA repair efficiency.
Topics: Animals; Caffeine; Cell Division; Cell Survival; DNA; DNA Damage; DNA Repair; Drug Synergism; In Vitro Techniques; Leukemia L5178; Methotrexate; Mice; Tumor Cells, Cultured | 1989 |
Methodology for the study of the effect of drugs on development and DNA replication in Drosophila melanogaster embryonic tissue.
Topics: Animals; Caffeine; Cell Membrane Permeability; Cell Nucleus; Colchicine; DNA Replication; Drosophila melanogaster; Embryo, Nonmammalian; Female; Floxuridine; Kinetics; Methotrexate; Microscopy, Electron; Oviposition; Ovum | 1984 |
Effects of metabolic inhibitors on cell lethality and mutation induction in Chinese hamster cells. I. Inhibitors of de novo purine synthesis and a comparison with the effects of caffeine.
Topics: Animals; Azaserine; Caffeine; Cell Line; Cricetinae; Cricetulus; Ethyl Methanesulfonate; Lung; Methotrexate; Methylthioinosine; Mutation; Purines; Ultraviolet Rays | 1981 |
[Chemotherapy for Ewing's sarcoma, malignant fibrous histiocytoma and malignant lymphoma].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; Doxorubicin; Histiocytoma, Benign Fibrous; Humans; Lymphoma; Male; Methotrexate; Sarcoma, Ewing | 1993 |
Induction of cytogenetic damage in human lymphocytes in vitro and of antineoplastic effects in Ehrlich ascites tumor cells in vivo treated by methotrexate, hyperthermia and/or caffeine.
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Body Weight; Caffeine; Carcinoma, Ehrlich Tumor; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Fever; Humans; Lymphocytes; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Sister Chromatid Exchange; Survival Rate | 1998 |
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Experimental; Arthrography; Caffeine; Female; Methotrexate; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Lew; Theophylline | 2000 |
Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Coffee; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Phosphodiesterase Inhibitors | 2003 |
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles | 2006 |
Caffeine consumption and methotrexate dosing requirement in psoriasis and psoriatic arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Psoriatic; Caffeine; Dermatologic Agents; Drug Interactions; Female; Food-Drug Interactions; Humans; Male; Methotrexate; Middle Aged; Psoriasis | 2007 |
An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring Dimension RxL Max clinical chemistry system.
Topics: Amikacin; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Caffeine; Central Nervous System Stimulants; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Humans; Methotrexate; Sensitivity and Specificity | 2007 |
Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
Topics: Caffeine; Cytokines; Gene Expression Regulation; Gene Silencing; Humans; Immunosuppressive Agents; Low Density Lipoprotein Receptor-Related Protein-1; Methotrexate; Mitogens; RNA, Small Interfering; T-Lymphocytes; Theophylline; Thrombospondin 1 | 2016 |
Methotrexate intolerance in the treatment of rheumatoid arthritis (RA): effect of adding caffeine to the management regimen.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Chocolate; Coffee; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; India; Male; Methotrexate; Middle Aged; Treatment Outcome; Xanthines | 2017 |
Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies.
Topics: Astrocytes; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Caffeine; Cell Line; Culture Media, Conditioned; Endothelial Cells; Humans; Methotrexate; Rivaroxaban | 2018 |
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.
Topics: Adenosine; Caffeine; Chitosan; Folic Acid; Humans; Immunotherapy; Methotrexate; Molecular Docking Simulation; Nanoparticles; Neoplasms; Receptor, Adenosine A2A; Tumor Microenvironment | 2023 |