caffeine and methadone

caffeine has been researched along with methadone in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199011 (31.43)18.7374
1990's1 (2.86)18.2507
2000's9 (25.71)29.6817
2010's13 (37.14)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Glen, RC; Lowe, R; Mitchell, JB1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Geber, WF; Hung, CY; Lefkowitz, SS1
Falek, A; Glick, JH; Madden, JJ; Shafer, DA1
Lefkowitz, SS; Nemeth, D1
Bauer, G; Konzett, H; Ziegler, E1
Jurand, J; Knox, JH1
Gorodetzky, CW; Kullberg, MP1
Abola, EE; Deutsch, HF; Edmundson, AB; Ely, KR; Fausch, MD; Girling, RL; Schiffer, M; Westholm, FA1
Baden, MM; Valanju, NN; Valanju, SN; Verma, SK1
Frank, GB; Rohani, F1
Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F1
JACOB, J; MICHAUD, G1
Beijnen, JH; de Jonge, ME; den Hoed, R; Hendriks, VM; Huitema, AD; Sparidans, RW; van den Brink, W; van Ree, JM; Zandvliet, AS1
De Giovanni, N; Fucci, N; Scarlata, S1
Bertol, E; Mari, F; Politi, L1
Iqbal, MZ; Lagundoye, O; Lennard, MS; Rostami-Hodjegan, A; Seivewright, N; Shiran, MR; Tucker, GT1
Galceran, MT; Huerta-Fontela, M; Rosa Boleda, M; Ventura, F1
Drennan, D; Farahmand, N; Junkins, S1
Barbera, N; Busardò, FP; Indorato, F; Romano, G1
Cooley, J; Lopez-Avila, V; Thevis, M; Urdahl, R1
Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Pearlman, H; Rammelsberg, D; Townsend, R; Yamazaki, T1
Mohs, AJ; Peace, MR; Poklis, A; Poklis, JL; Wolf, CE1
Csorba, J; Figeczki, T; Gyarmathy, VA; Kiss, J; Medgyesi-Frank, K; Péterfi, A; Posta, J2
Alavi Nikje, MM; Soleimani, M; Tavakoli, Z1
Carnevale Miino, M; Chorazy, T; Halešová, T; Hlavínek, P; Macsek, T1

Reviews

1 review(s) available for caffeine and methadone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for caffeine and methadone

ArticleYear
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
    Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Biological Availability; Caffeine; Central Nervous System Stimulants; Drug Combinations; Drug Interactions; Half-Life; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Narcotics; Population; Theobromine; Theophylline

2005
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:1

    Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult

2017

Other Studies

32 other study(ies) available for caffeine and methadone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Effect of morphine, hydromorphone, methadone, mescaline, trypan blue, vitamin A, sodium salicylate, and caffeine on the serum interferon level in response to viral infection.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 214, Issue:2

    Topics: Animals; Caffeine; Hydromorphone; Interferons; Male; Mescaline; Methadone; Mice; Morphine; Salicylates; Trypan Blue; Vesicular stomatitis Indiana virus; Virus Diseases; Vitamin A

1975
Effects of opiates and demographic factors on DNA repair synthesis in human leukocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Age Factors; Caffeine; DNA Repair; Female; Heroin Dependence; Humans; Leukocytes; Male; Methadone; Middle Aged; Sex Factors; Smoking; Ultraviolet Rays

1979
Immunosuppression of rosette-forming cells.
    Advances in experimental medicine and biology, 1976, Volume: 73 Pt B

    Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; Immunosuppression Therapy; Leukocytes; Male; Methadone; Mice; Morphine; Organ Size; Pentobarbital; Phenobarbital; Sheep; Spleen; Substance-Related Disorders

1976
Drugs in breast milk.
    The Medical letter on drugs and therapeutics, 1974, Mar-15, Volume: 16, Issue:6

    Topics: Anticoagulants; Anticonvulsants; Antineoplastic Agents; Antithyroid Agents; Aspirin; Atropine; Caffeine; Chloramphenicol; Chlorothiazide; Contraceptives, Oral; Ergot Alkaloids; Ethanol; Female; Humans; Hypnotics and Sedatives; Methadone; Milk, Human; Nalidixic Acid; Narcotics; Penicillins; Quinine; Reserpine; Sulfonamides; Tetracycline

1974
[On the inhibitory effect of kinins on isolated intestinal sections].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie und experimentelle Pathologie, 1966, Volume: 254, Issue:3

    Topics: Anesthetics, Local; Animals; Atropine; Bradykinin; Caffeine; Duodenum; Ganglionic Blockers; Guanethidine; Ileum; Jejunum; Kallidin; Meperidine; Methadone; Morphine; Phenylbutazone; Rabbits

1966
Separation of morphine alkaloids, heroin, methadone and other drugs by ion-exchange chromatography.
    Journal of chromatography, 1973, Aug-01, Volume: 82, Issue:2

    Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Heroin; Methadone; Methods; Morphine; Opium; Phenacetin; Solvents

1973
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
    Clinical chemistry, 1974, Volume: 20, Issue:2

    Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cocaine; Codeine; Evaluation Studies as Topic; Glucuronates; Humans; Hydrolysis; Meperidine; Meprobamate; Mescaline; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Naloxone; Pentobarbital; Secobarbital; Substance-Related Disorders

1974
Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer.
    Biochemistry, 1974, Aug-27, Volume: 13, Issue:18

    Topics: Amino Acid Sequence; Amino Acids; Amyloidosis; Bence Jones Protein; Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Colchicine; Dansyl Compounds; Fluorine; Humans; Immunoglobulin Fragments; Immunoglobulins; Iodine; Macromolecular Substances; Methadone; Models, Structural; Morphine; Nitrobenzenes; Phenanthrolines; Protein Binding; Protein Conformation; Uracil; Vitamin K; X-Ray Diffraction

1974
Confirmed identification of biotransformed drugs of abuse in urine.
    American journal of clinical pathology, 1972, Volume: 57, Issue:1

    Topics: Amphetamine; Analgesics; Barbiturates; Biotransformation; Caffeine; Cannabis; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Methadone; Morphine; Nicotine; Pharmaceutical Preparations; Procaine; Skin; Spectrum Analysis; Substance-Related Disorders; Tranquilizing Agents

1972
Calcium antagonism of an opiate drug effect on an excitable cell membrane.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Action Potentials; Animals; Caffeine; Calcium; Cell Membrane; Methadone; Rana pipiens; Receptors, Opioid; Tetrodotoxin

1983
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bupivacaine; Caffeine; Central Nervous System Stimulants; Cranial Nerve Diseases; Facial Paralysis; Female; Fluid Therapy; Headache; Humans; Infant, Newborn; Intracranial Hypotension; Lysine; Methadone; Narcotics; Obstetric Labor, Premature; Opioid-Related Disorders; Palliative Care; Paralysis; Pregnancy; Spinal Puncture; Syndrome; Trigeminal Nerve

1998
[The effect of various pharmacological agents (amphetamine, cocaine, caffeine, hexobarbital, meprobamate, morphine, dextromoramide, 1-methadone, pethidine and CT 3570) on the time of exhaustion and behavior of animals swimming at 20 degrees C].
    Medicina experimentalis : International journal of experimental medicine, 1960, Volume: 2

    Topics: Amphetamine; Amphetamines; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Behavior; Caffeine; Central Nervous System Stimulants; Cocaine; Dextromoramide; Hexobarbital; Hypnotics and Sedatives; Meperidine; Meprobamate; Methadone; Morphine; Physical Exertion; Swimming; Tomography, X-Ray Computed

1960
Sweat testing in addicts under methadone treatment: an Italian experience.
    Forensic science international, 2008, Jan-30, Volume: 174, Issue:2-3

    Topics: Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Humans; Italy; Male; Methadone; Middle Aged; Narcotics; Nicotine; Pyrrolidines; Sweat

2008
Nails of newborns in monitoring drug exposure during pregnancy.
    Forensic science international, 2008, Aug-06, Volume: 179, Issue:2-3

    Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine; Nails; Narcotics; Nicotine; Nicotinic Agonists; Pregnancy; Smoking

2008
Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:1

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; Female; Humans; Isomerism; Male; Methadone; Midazolam; Middle Aged; Narcotics; Opioid-Related Disorders; Saliva; Young Adult

2009
Evaluation of the presence of drugs of abuse in tap waters.
    Chemosphere, 2011, Volume: 84, Issue:11

    Topics: Caffeine; Chromatography, High Pressure Liquid; Cocaine; Cotinine; Drinking Water; Environmental Monitoring; Illicit Drugs; Methadone; Nicotine; Pyrrolidines; Spectrometry, Mass, Electrospray Ionization

2011
Patient education and self-advocacy: queries and responses on pain management.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:4

    Topics: Caffeine; Chronic Pain; Headache; Humans; Methadone; Pain Management; Sleep Apnea Syndromes

2008
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
    Forensic science international, 2013, Apr-10, Volume: 227, Issue:1-3

    Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body

2013
Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source.
    Rapid communications in mass spectrometry : RCM, 2012, Dec-15, Volume: 26, Issue:23

    Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Codeine; Dopamine Uptake Inhibitors; Equipment Design; GABA Antagonists; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Ions; Methadone; Narcotics; Nicotine; Nikethamide; Norbornanes; Pentylenetetrazole; Phenmetrazine; Sensitivity and Specificity

2012
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
    Journal of analytical toxicology, 2016, Volume: 40, Issue:8

    Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine

2016
Drug residues in syringes and other injecting paraphernalia in Hungary.
    Drug testing and analysis, 2018, Volume: 10, Issue:2

    Topics: Alkaloids; Caffeine; Drug Residues; Europe; Humans; Hungary; Methadone; Prevalence; Syringes

2018
Diverted medications and new psychoactive substances-A chemical network analysis of discarded injecting paraphernalia in Hungary.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Benzoic Acid; Caffeine; Humans; Hungary; Illicit Drugs; Methadone; Needle Sharing; Opiate Substitution Treatment; Prescription Drug Diversion; Prevalence; Psychotropic Drugs; Substance Abuse, Intravenous; Syringes

2017
Characterization and performance evaluation of functional monomer effect on molecular imprinted polyurethane foam.
    Journal of chromatography. A, 2019, Sep-27, Volume: 1602

    Topics: Alprazolam; Caffeine; Chromatography, High Pressure Liquid; Drug Monitoring; Hydrogen-Ion Concentration; Methadone; Molecular Imprinting; Polymers; Polyurethanes; Salts; Solid Phase Extraction

2019
Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach.
    The Science of the total environment, 2023, Sep-15, Volume: 891

    Topics: Amphetamine; Caffeine; Cocaine; Environmental Monitoring; Heroin; Humans; Illicit Drugs; Methadone; Methamphetamine; Narcotics; Seasons; Substance Abuse Detection; Substance-Related Disorders; Wastewater; Wastewater-Based Epidemiological Monitoring; Water Pollutants, Chemical

2023