caffeine and mephenytoin

caffeine has been researched along with mephenytoin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (33.33)18.2507
2000's11 (45.83)29.6817
2010's5 (20.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brockmöller, J; Brösicke, H; Helge, H; Roots, I; Rost, KL; Scheffler, M1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Brösicke, H; Heinemeyer, G; Roots, I; Rost, KL1
Caslavska, J; Desiderio, C; Hufschmid, E; Theurillat, R; Thormann, W; Wolfisberg, H1
Roots, I; Rost, KL1
Brøsen, K; Gram, LF; Jeppesen, U; Loft, S; Poulsen, HE; Vistisen, K1
Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA1
Baumann, P; Buchwalder, PA; Buclin, T; Eap, CB; Gutmann, N1
Adedoyin, A; Branch, RA; Frye, RF; Romkes, M; Wilson, JW1
Baumann, P; Bondolfi, G; Bryois, C; Eap, CB; Fuciec, M; Jonzier-Perey, M; Savary, L; Zullino, D1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ1
Branch, RA; Frye, RF1
Brøsen, K; Christensen, HR; Jürgens, G; Loft, S; Olsen, NV; Sonne, J1
Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH1
Abd El-Aty, AM; An, W; Chen, GL; Li, Q; Li, Z; Liu, J; Tang, ZR; Wang, D; Wang, LS; Wu, J; Zhou, G; Zhou, HH; Zhu, B1
Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK1
Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK1
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US1
Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD1

Reviews

1 review(s) available for caffeine and mephenytoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

9 trial(s) available for caffeine and mephenytoin

ArticleYear
Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Breath Tests; Caffeine; Carbon Dioxide; Carbon Isotopes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases; Phenotype

1992
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures.
    Journal of chromatography. B, Biomedical applications, 1994, Jun-03, Volume: 656, Issue:1

    Topics: Acetylation; Adult; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxylation; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic

1994
Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine.
    European journal of clinical pharmacology, 1996, Volume: 51, Issue:1

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Citalopram; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sparteine

1996
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

    Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values

1997
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:5

    Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating

2001
The influence of St John's Wort on CYP2C19 activity with respect to genotype.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:6

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Genotype; Humans; Hypericum; Male; Mephenytoin; Mixed Function Oxygenases; Plant Extracts; Polymorphism, Genetic

2004
Liver disease selectively modulates cytochrome P450--mediated metabolism.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline

2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged

2006
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
    Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged

2007

Other Studies

14 other study(ies) available for caffeine and mephenytoin

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
Specific and dose-dependent enzyme induction by omeprazole in human beings.
    Hepatology (Baltimore, Md.), 1994, Volume: 20, Issue:5

    Topics: Absorption; Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; gamma-Glutamyltransferase; Glutarates; Half-Life; Humans; Hydrocortisone; Male; Mephenytoin; Methylation; Middle Aged; Omeprazole; Oxidoreductases

1994
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.
    Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Theophylline; Uric Acid

1994
Multiple and simultaneous phenotyping tests: beware of ascorbic acid when determining the mephenytoin (S)/(R) ratio.
    Clinica chimica acta; international journal of clinical chemistry, 1998, Mar-09, Volume: 271, Issue:1

    Topics: Ascorbic Acid; Caffeine; Cytochrome P-450 Enzyme System; Humans; Hydrogen-Ion Concentration; Inactivation, Metabolic; Isoenzymes; Mephenytoin; Phenotype; Polymorphism, Genetic; Stereoisomerism

1998
In vivo modulation of CYP enzymes by quinidine and rifampin.
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4

    Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline

2000
Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test.
    Therapeutic drug monitoring, 2001, Volume: 23, Issue:3

    Topics: Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Risperidone

2001
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors

2002
Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:4

    Topics: Acute Disease; Adult; Altitude; Caffeine; Cytochrome P-450 Enzyme System; Female; Humans; Hydrocortisone; Hypoxia; Liver; Longitudinal Studies; Male; Mephenytoin; Sparteine; Statistics, Nonparametric

2002
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
    Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline

2003
Predicted metabolic drug clearance with increasing adult age.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Warfarin

2013