caffeine and losartan

caffeine has been researched along with losartan in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (5.13)	18.2507
2000's	7 (17.95)	29.6817
2010's	23 (58.97)	24.3611
2020's	7 (17.95)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Jackson, EK; Kost, CK; Li, P; Pfeifer, CA	1
Gelband, CH; Martens, JR; Posner, P; Sumners, C; Wang, D	1
Cha, IJ; Liu, KH; Ryu, JY; Shin, JG; Shon, JH; Song, IS; Sunwoo, YE	1
Andersson, TB; Bäckström, T; Bertilsson, L; Böttiger, Y; Bredberg, E; Diczfalusy, U; Kanebratt, KP; Sparve, E	1
Chem, MC; Chetty, M; Ghassabian, S; Glen, J; McLachlan, AJ; Murray, M; Rahme, J; Ramzan, I; Stankovic, Z; Tattam, BN	1
Cho, JY; Hong, JH; Jang, IJ; Kim, BH; Kim, J; Kim, KP; Lim, KS; Shin, SG; Yi, S; Yu, KS	1
Chen, Y; Guo, Y; Klaassen, CD; Tan, ZR; Zhou, HH	1
Kim, DH; Oh, KS; Park, SJ; Shin, JG; Shinde, DD	1
Beltrán, LJ; Dorado, P; Llerena, A; Machín, E; Peñas-Lledó, EM; Terán, E	1
Brosen, K; Christensen, MM; Damkier, P; Pedersen, RS	1
Akamatsu, T; Chida, K; Inui, N; Karayama, M; Namiki, N; Tanaka, S; Uchida, S; Watanabe, H	1
Namiki, N; Tanaka, S; Uchida, S	1
de Andrés, F; Llerena, A; Sosa-Macías, M	1
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD	1
Berger, B; Derungs, A; Donzelli, M; Haschke, M; Krähenbühl, S; Noppen, C	1
Bovera, M; de Andrés, F; Fariñas, H; LLerena, A; Terán, E; Terán, S	1
Hellum, B; Nilsen, OG; Spigset, O; Thu, OK	1
Jeon, JY; Kim, DS; Kim, MG; Kim, Y	1
Mangoni, AA; Rowland, A; Sorich, MJ; van Dyk, M; Warncken, D	1
Choi, MK; Choi, WG; Han, YH; Heo, JK; Jo, J; Kang, WY; Lee, HS; Lee, HW; Lee, S; Liu, KH; Ohk, B; Seong, SJ; Song, IS; Yoon, YR	1
Cintra, MACT; Coelho, EB; Cusinato, DAC; Filgueira, GCO; Lanchote, VL; Rocha, A	1
Eagles, SK; Gross, AS; McLachlan, AJ; Wang, X	1
Hakamata, A; Inui, N; Kamiya, C; Katayama, N; Kawakami, J; Miura, M; Namiki, N; Odagiri, K; Tanaka, S; Uchida, S; Watanabe, H	1
Correia, AT; Guimarães, LL; Roveri, V; Toma, W	2
Correia, AT; de Oliveira, TMN; Guimarães, LL; Pisetta, AM; Roveri, V	1
Bansal, S; Paine, MF; Spindle, TR; Thummel, KE; Unadkat, JD; Vandrey, R; Weerts, EM; Zamarripa, CA	1

Reviews

2 review(s) available for caffeine and losartan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022

Trials

9 trial(s) available for caffeine and losartan

Article	Year
Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5 Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Genotype; Humans; Isoenzymes; Linear Models; Losartan; Male; Midazolam; Mixed Function Oxygenases; Omeprazole; Phenotype; Polymerase Chain Reaction; Reference Values; Time Factors	2007
Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:5 Topics: Adult; Anti-Ulcer Agents; Antibiotics, Antitubercular; Antihypertensive Agents; Antimalarials; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Drug Combinations; Enzyme Induction; Female; Humans; Hydroxycholesterols; Losartan; Male; Middle Aged; Omeprazole; Quinine; Rifampin	2008
Repeated administration of berberine inhibits cytochromes P450 in humans. European journal of clinical pharmacology, 2012, Volume: 68, Issue:2 Topics: Adult; Berberine; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult	2012
A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers. European journal of clinical pharmacology, 2013, Volume: 69, Issue:12 Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Combinations; Female; Genotype; Healthy Volunteers; Humans; Losartan; Male; Middle Aged; Omeprazole; Phenotype; Tramadol; Young Adult	2013
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European journal of clinical pharmacology, 2014, Volume: 70, Issue:9 Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult	2014
Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clinical pharmacokinetics, 2016, Volume: 55, Issue:1 Topics: Adult; Alkynes; Benzoxazines; Caffeine; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Genotype; Humans; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Phenotype; Young Adult	2016
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. European journal of clinical pharmacology, 2016, Volume: 72, Issue:3 Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Plant Extracts; Rhodiola; Young Adult	2016
Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol. British journal of clinical pharmacology, 2018, Volume: 84, Issue:3 Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Losartan; Male; Midazolam; Modafinil; Omeprazole; Phenotype; Time Factors; Young Adult	2018
Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities. Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:6 Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Male; Midazolam; Models, Biological; Omeprazole; Young Adult	2021

Other Studies

28 other study(ies) available for caffeine and losartan

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Telemetric blood pressure monitoring in benign 2-kidney, 1-clip renovascular hypertension: effect of chronic caffeine ingestion. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3 Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Caffeine; Captopril; Constriction; Heart Rate; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Telemetry; Tetrazoles	1994
Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem. Journal of neurochemistry, 1996, Volume: 67, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Astrocytes; Biphenyl Compounds; Brain Stem; Cadmium; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gadolinium; Hypothalamus; Imidazoles; Indoles; Losartan; Nifedipine; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Ryanodine; Terpenes; Tetrazoles; Thapsigargin; Time Factors	1996
A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients. Therapeutic drug monitoring, 2009, Volume: 31, Issue:2 Topics: Biotransformation; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Midazolam; Omeprazole; Phenotype; Tandem Mass Spectrometry	2009
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers. Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:4 Topics: Adult; Angelica; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Phytotherapy; Republic of Korea; Scutellaria baicalensis; Tandem Mass Spectrometry; Young Adult	2009
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, May-01, Volume: 895-896 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Stability; Humans; Imidazoles; Linear Models; Liquid-Liquid Extraction; Losartan; Omeprazole; Pharmaceutical Preparations; Reproducibility of Results; Tandem Mass Spectrometry; Tetrazoles; Theophylline	2012
Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender. Pharmacogenomics, 2012, Volume: 13, Issue:15 Topics: Adult; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Caffeine; Coffee; Cytochrome P-450 CYP2C9; Female; Genotype; Habits; Hispanic or Latino; Humans; Hydroxylation; Losartan; Male; Phenotype; Polymorphism, Genetic; Sex Factors; Smoking; Young Adult	2012
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method. Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:6 Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment	2013
Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats. Biopharmaceutics & drug disposition, 2014, Volume: 35, Issue:4 Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Drug Interactions; Fluconazole; Fluvoxamine; Ketoconazole; Losartan; Male; Midazolam; Omeprazole; Rats, Sprague-Dawley	2014
A rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity. Bioanalysis, 2014, Volume: 6, Issue:5 Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Hydroxylation; Losartan; Omeprazole; Tandem Mass Spectrometry	2014
Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach. Omics : a journal of integrative biology, 2016, Volume: 20, Issue:2 Topics: Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Inactivation, Metabolic; Losartan; Omeprazole; Phenotype; Young Adult	2016
Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach. British journal of clinical pharmacology, 2016, Volume: 82, Issue:6 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Fermented Foods; Healthy Volunteers; Humans; Losartan; Male; Midazolam; Middle Aged; Omeprazole; Panax; Pharmaceutical Preparations; Terfenadine; Young Adult	2016
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng. Clinical therapeutics, 2018, Volume: 40, Issue:8 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Liver-Specific Organic Anion Transporter 1; Losartan; Male; Midazolam; Omeprazole; Panax; Plant Preparations; Random Allocation; Young Adult	2018
LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses. Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Variation, Population; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Healthy Volunteers; Humans; Isoenzymes; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine	2019
An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Mar-01, Volume: 1140 Topics: Biosensing Techniques; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Limit of Detection; Losartan; Midazolam; Omeprazole; Phenotype; Sensitivity and Specificity; Tandem Mass Spectrometry	2020
Occurrence of pharmaceuticals and cocaine in the urban drainage channels located on the outskirts of the São Vicente Island (São Paulo, Brazil) and related ecological risk assessment. Environmental science and pollution research international, 2022, Volume: 29, Issue:38 Topics: Acetaminophen; Brazil; Caffeine; Carbamazepine; Cocaine; Environmental Monitoring; Humans; Losartan; Pharmaceutical Preparations; Risk Assessment; Water Pollutants, Chemical	2022
First report on the occurrence of pharmaceuticals and cocaine in the coastal waters of Santa Catarina, Brazil, and its related ecological risk assessment. Environmental science and pollution research international, 2022, Volume: 29, Issue:42 Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Cosmetics; Diclofenac; Ecosystem; Environmental Monitoring; Humans; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Sewage; Solid Waste; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical	2022
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil. Environmental science and pollution research international, 2022, Volume: 29, Issue:59 Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical	2022
Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clinical pharmacology and therapeutics, 2023, Volume: 114, Issue:3 Topics: Adult; Caffeine; Cannabidiol; Cannabinoids; Cannabis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dronabinol; Drug Interactions; Hallucinogens; Humans; Losartan; Midazolam; Omeprazole; Plant Extracts	2023