caffeine and levodopa

caffeine has been researched along with levodopa in 56 studies

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19909 (16.07)18.7374
1990's1 (1.79)18.2507
2000's25 (44.64)29.6817
2010's18 (32.14)24.3611
2020's3 (5.36)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Jolivette, LJ; Ward, KW1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Giralt, E; Malakoutikhah, M; Teixidó, M1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G1
Hagino, K; Ikeda, M; Watanabe, H; Watanabe, K1
Chase, T; Shoulson, I1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S1
Adams, JE; Harkins, D; Simpson, CC; White, BC1
Cheng, LC; Rogus, EM; Zierler, K1
Reus, VI1
Hollister, LE1
Chase, TN; Shoulson, I1
Ikeda, M; Watanabe, H; Watanabe, K1
Ichikawa, S; Kitamura, S; Kuwana, Y; Nakamura, J; Shiozaki, S; Yamada, K1
Bonastre, M; Bové, J; Marin, C; Tolosa, E1
Angelucci, ME; Canteras, NS; Da Cunha, C; Takahashi, RN; Wonnacott, S1
Kim, DS; Palmiter, RD1
Chen, JF1
Dziubina, A; Gołembiowska, K3
Chen, JF; Schwarzschild, MA; Yu, L1
Cauli, O; Morelli, M; Pinna, A1
Hnasko, TS; Palmiter, RD; Sotak, BN1
Aguilar, E; Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J1
Chand, P; Colwell, A; Deleu, D; Jacob, P; Sarre, S1
Hnasko, TS; Palmiter, RD; Rainwater, AJ; Robinson, S1
Barbanoj, M; Kulisevsky, J; Pérez, V; Rodríguez-Alvarez, J; Rubio, A; Sosti, V1
Kelsey, JE; Langelier, NA; Oriel, BS; Reedy, C1
Barodia, SK; Luthra, PM; Raghubir, R1
Ba, M; Kong, M; Liu, Z; Ma, Y; Song, L1
Chen, JF; Herm, L; Kalda, A; Rinken, A; Zharkovsky, A1
Burdett, TC; Cassin, JJ; Chen, JF; Fredholm, BB; Healy, B; Schwarzschild, MA; Xiao, D1
Hu, WD; Huang, YX; Li, D; Liu, CF; Luo, WF1
Darvas, M; Fadok, JP; Palmiter, RD1
Chen, JF; Eberly, S; Kamp, C; Lang, AE; McDermott, MP; Messing, S; Oakes, D; Schwarzschild, MA; Tanner, CM; Tennis, M; Togasaki, D; Wills, AM1
Jenner, P1
Amboni, M; Barone, P; Erro, R; Longo, K; Moccia, M; Pellecchia, MT; Picillo, M; Vitale, C1
Ahmed, H; Attia, D; Elfil, M; Essam, A; Farahat, E; Gabr, M; Negida, A1
Sintov, AC1
Bai, CH; Chan, L; Hong, CT1
Manalo, RVM; Medina, PMB1

Reviews

6 review(s) available for caffeine and levodopa

ArticleYear
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
    European journal of medicinal chemistry, 2022, Jan-05, Volume: 227

    Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship

2022
Drugs and sexual behavior in man.
    Life sciences, 1975, Sep-01, Volume: 17, Issue:5

    Topics: Amyl Nitrite; Barbiturates; Caffeine; Cannabis; Erectile Dysfunction; Ethanol; Gonadal Steroid Hormones; Humans; Levodopa; Lithium; Male; Nicotine; Opium; Sexual Behavior; Thioridazine

1975
The lesion of the rat substantia nigra pars compacta dopaminergic neurons as a model for Parkinson's disease memory disabilities.
    Cellular and molecular neurobiology, 2002, Volume: 22, Issue:3

    Topics: Animals; Caffeine; Disease Models, Animal; Humans; Levodopa; Memory Disorders; Neurons; Parkinsonian Disorders; Rats; Receptors, Dopamine; Receptors, Purinergic P1; Substantia Nigra

2002
The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment.
    Drug news & perspectives, 2003, Volume: 16, Issue:9

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Brain; Caffeine; Dopamine; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Receptor, Adenosine A2A; Treatment Failure

2003
Caffeine; the Forgotten Potential for Parkinson's Disease.
    CNS & neurological disorders drug targets, 2017, Volume: 16, Issue:6

    Topics: Animals; Antiparkinson Agents; Caffeine; Drug Synergism; Humans; Levodopa; Parkinson Disease

2017
The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis.
    Nutrients, 2020, Jun-22, Volume: 12, Issue:6

    Topics: Caffeine; Coffee; Cohort Studies; Disease Progression; Humans; Levodopa; Parkinson Disease; Proportional Hazards Models

2020

Trials

3 trial(s) available for caffeine and levodopa

ArticleYear
Caffeine and the antiparkinsonian response to levodopa or piribedil.
    Neurology, 1975, Volume: 25, Issue:8

    Topics: Adult; Aged; Caffeine; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; Female; Humans; Huntington Disease; Levodopa; Male; Middle Aged; Parkinson Disease; Piperazines; Piribedil

1975
Effects of caffeine on levodopa pharmacokinetics and pharmacodynamics in Parkinson disease.
    Neurology, 2006, Sep-12, Volume: 67, Issue:5

    Topics: Adult; Aged; Antiparkinson Agents; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors

2006
Caffeine consumption and risk of dyskinesia in CALM-PD.
    Movement disorders : official journal of the Movement Disorder Society, 2013, Volume: 28, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Aged; Antiparkinson Agents; Benzothiazoles; Caffeine; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Kaplan-Meier Estimate; Levodopa; Male; Middle Aged; Parkinson Disease; Pramipexole; Proportional Hazards Models; Retrospective Studies; Risk

2013

Other Studies

47 other study(ies) available for caffeine and levodopa

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Biological Transport; Blood-Brain Barrier; Cell Survival; Drug Carriers; Humans; Levodopa; Membranes, Artificial; Peptide Library; Peptides; Permeability; Phenylalanine; Solubility

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Effects of dopaminergic stimulating agents, caffeine and antipsychotic drugs on rotational behaviour in mice with unilateral striatal 6-hydroxydopamine lesions (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1978, Volume: 98, Issue:12

    Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain Diseases; Caffeine; Corpus Striatum; Hydroxydopamines; In Vitro Techniques; Levodopa; Male; Methamphetamine; Methods; Mice; Receptors, Dopamine; Rotation

1978
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline

1977
Monoamine synthesis and caffeine-induced locomotor activity.
    Neuropharmacology, 1978, Volume: 17, Issue:7

    Topics: Animals; Biogenic Amines; Caffeine; Fenclonine; Levodopa; Male; Methyltyrosines; Motor Activity; Rats; Time Factors

1978
beta-Adrenergic effect on Na+-K+ transport in rat skeletal muscle.
    Biochimica et biophysica acta, 1977, Jan-21, Volume: 464, Issue:2

    Topics: Animals; Biological Transport, Active; Bucladesine; Caffeine; Catechols; Isoproterenol; Kinetics; Levodopa; Male; Models, Biological; Muscles; Ouabain; Oxidation-Reduction; Potassium; Rats; Sodium

1977
Behavioral side effects of medical drugs.
    Primary care, 1979, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Caffeine; Cimetidine; Contraceptives, Oral, Hormonal; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Levodopa; Male; Mental Disorders; Parasympatholytics; Placebos; Propranolol; Psychoses, Substance-Induced; Reserpine; Sympathomimetics; Thyroid Hormones

1979
Dopaminergic mechanisms in patients with extrapyramidal disease.
    Advances in neurology, 1975, Volume: 9

    Topics: Animals; Biogenic Amines; Brain; Caffeine; Clonidine; Dopamine; Drug Evaluation; Drug Therapy, Combination; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Parasympatholytics; Parkinson Disease; Piperazines; Piribedil; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Drug; Stimulation, Chemical

1975
Development of tolerance to dopaminergic stimulating effect of theophylline in mice with unilateral striatal 6-hydroxydopamine lesions.
    European journal of pharmacology, 1982, Apr-08, Volume: 79, Issue:1-2

    Topics: Animals; Caffeine; Corpus Striatum; Drug Tolerance; Humans; Hydroxydopamines; Levodopa; Male; Mice; Receptors, Dopamine; Stereotyped Behavior; Theophylline

1982
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
    Psychopharmacology, 1999, Volume: 147, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Caffeine; Catalepsy; Dopamine Agents; Hypokinesia; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Reserpine; Theophylline

1999
Adenosine A2A antagonism reverses levodopa-induced motor alterations in hemiparkinsonian rats.
    Synapse (New York, N.Y.), 2002, Dec-15, Volume: 46, Issue:4

    Topics: Animals; Caffeine; Levodopa; Male; Motor Activity; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1

2002
Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Feb-04, Volume: 100, Issue:3

    Topics: Amygdala; Animals; Body Weight; Brain; Caffeine; Central Nervous System Stimulants; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Genotype; Hypothalamus; Immunohistochemistry; Levodopa; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins c-fos; Receptors, Purinergic P1; Signal Transduction; Time Factors

2003
Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on L-DOPA biotransformation in rat striatum.
    Brain research, 2004, Feb-20, Volume: 998, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Benserazide; Brain Chemistry; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Reserpine

2004
Cross-sensitization between caffeine- and L-dopa-induced behaviors in hemiparkinsonian mice.
    Neuroscience letters, 2006, Jan-23, Volume: 393, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Levodopa; Mice; Mice, Inbred C57BL; Oxidopamine; Parkinson Disease, Secondary; Random Allocation; Time Factors

2006
Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonists.
    Behavioural pharmacology, 2005, Volume: 16, Issue:8

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics

2005
Morphine reward in dopamine-deficient mice.
    Nature, 2005, Dec-08, Volume: 438, Issue:7069

    Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Mice; Morphine; Motor Activity; Pain; Pain Threshold; Reward; Tail; Tyrosine 3-Monooxygenase

2005
Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats.
    Synapse (New York, N.Y.), 2006, Jun-01, Volume: 59, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic Agents; Animals; Caffeine; Corpus Striatum; Dynorphins; Dyskinesias; Enkephalins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger

2006
Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice.
    Psychopharmacology, 2007, Volume: 191, Issue:3

    Topics: Adenoviruses, Canine; Animals; Association Learning; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Corpus Striatum; Cues; Dopamine; Dopamine Agents; Dopamine beta-Hydroxylase; Feeding Behavior; Gene Transfer Techniques; Genetic Vectors; Levodopa; Male; Mice; Mice, Knockout; Motivation; Motor Activity; Reinforcement Schedule; Reward; Substantia Nigra; Tyrosine 3-Monooxygenase

2007
Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration.
    European journal of pharmacology, 2007, Dec-08, Volume: 576, Issue:1-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Benzylamines; Brain; Caffeine; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Male; Motor Activity; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley

2007
The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat.
    Psychopharmacology, 2009, Volume: 201, Issue:4

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Caffeine; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Globus Pallidus; Injections; Levodopa; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Long-Evans

2009
Antagonism of haloperidol-induced swim impairment in L-dopa and caffeine treated mice: a pre-clinical model to study Parkinson's disease.
    Journal of neuroscience methods, 2009, Apr-15, Volume: 178, Issue:2

    Topics: Analysis of Variance; Animals; Antiparkinson Agents; Caffeine; Catalepsy; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione; Haloperidol; Levodopa; Male; Mice; Motor Activity; Parkinsonian Disorders; Posture; Superoxide Dismutase; Swimming

2009
Inhibitory effect of 8-(3-chlorostryryl) caffeine on levodopa-induced motor fluctuation is associated with intracellular signaling pathway in 6-OHDA-lesioned rats.
    Brain research, 2009, Jun-18, Volume: 1276

    Topics: Adenosine A2 Receptor Agonists; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Levodopa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Motor Activity; Movement; Oxidopamine; Parkinson Disease, Secondary; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Signal Transduction; Up-Regulation

2009
Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice.
    Behavioural brain research, 2009, Sep-14, Volume: 202, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Benzazepines; Caffeine; Corpus Striatum; Dopamine Agonists; Drug Therapy, Combination; Guanosine 5'-O-(3-Thiotriphosphate); Levodopa; Lisuride; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Random Allocation; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulfur Radioisotopes

2009
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.
    Brain research, 2011, Jan-07, Volume: 1367

    Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidopamine; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Statistics, Nonparametric; Time Factors

2011
CSC counteracts l-DOPA-induced overactivity of the corticostriatal synaptic ultrastructure and function in 6-OHDA-lesioned rats.
    Brain research, 2011, Feb-28, Volume: 1376

    Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Brain; Caffeine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Levodopa; Male; Microscopy, Electron, Transmission; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Synapses

2011
Requirement of dopamine signaling in the amygdala and striatum for learning and maintenance of a conditioned avoidance response.
    Learning & memory (Cold Spring Harbor, N.Y.), 2011, Volume: 18, Issue:3

    Topics: Amygdala; Analysis of Variance; Animals; Avoidance Learning; Caffeine; Caveolin 2; Central Nervous System Stimulants; Conditioning, Classical; Corpus Striatum; Dopamine; Dopamine Agents; Escape Reaction; Fear; Levodopa; Mice; Mice, Knockout; Reaction Time; Signal Transduction; Tyrosine 3-Monooxygenase

2011
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
    Neurotoxicity research, 2012, Volume: 21, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles

2012
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
    Neurotoxicity research, 2012, Volume: 22, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins

2012
A cup of coffee a day keeps dyskinesia away?
    Movement disorders : official journal of the Movement Disorder Society, 2013, Volume: 28, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Antiparkinson Agents; Benzothiazoles; Caffeine; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Pramipexole

2013
Caffeine consumption and the 4-year progression of de novo Parkinson's disease.
    Parkinsonism & related disorders, 2016, Volume: 32

    Topics: Aged; Antiparkinson Agents; Caffeine; Cohort Studies; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Levodopa; Male; Middle Aged; Parkinson Disease; Proportional Hazards Models; Quality of Life; Surveys and Questionnaires; Time Factors

2016
Cumulative evidence of the low reliability of frozen/thawed pig skin as a model for in vitro percutaneous permeation testing.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, May-01, Volume: 102

    Topics: Administration, Cutaneous; Animals; Caffeine; Cryopreservation; Diclofenac; Freezing; In Vitro Techniques; Levodopa; Permeability; Reproducibility of Results; Skin; Skin Absorption; Swine

2017
Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic
    Pharmaceutical biology, 2020, Volume: 58, Issue:1

    Topics: Animals; Animals, Genetically Modified; Antiparkinson Agents; Caenorhabditis elegans; Caffeine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Levodopa; Locomotion; Neuroprotective Agents; Parkinsonian Disorders

2020