caffeine has been researched along with indomethacin in 112 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (28.57) | 18.7374 |
| 1990's | 17 (15.18) | 18.2507 |
| 2000's | 34 (30.36) | 29.6817 |
| 2010's | 29 (25.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Baba, T; Hayashi, H; Shimojima, Y; Shirai, T | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Varró, V | 1 |
| Breuiller, M; Cedard, L; Ferre, F | 1 |
| Bonta, IL; Vincent, JE; Zijlstra, FJ | 1 |
| Beatty, CH; Bocek, RM; Novy, MJ; Young, MK | 1 |
| Franks, DJ; Hamet, P; Horrobin, DF; Manku, MS | 1 |
| Breuiller, M; Cedard, L; de Pariente, D; Ferre, F | 1 |
| Ceserani, R; Costa, G; De Pasquale, A; Trovato, A | 1 |
| Cornwell, DG; Geer, JC; Huttner, JJ; Milo, GE; Panganamala, RV; Sharma, HM | 1 |
| Cooke, AR | 2 |
| Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G | 1 |
| Ellis, CH; Selph, JL; Truax, JF; Vinegar, R; Welch, RM; White, HL | 1 |
| Autret, E; Laugier, J; Nasr, C; Saliba, E; Suc, AL | 1 |
| Lerner, UH; Mellström, D | 1 |
| Cortijo, J; Morcillo, EJ; Ortiz, JL; Sanz, CM | 1 |
| Hasegawa, T; Kumagai, S | 1 |
| Boden, G; Hoeldtke, RD; O'Dorisio, TM | 1 |
| Boyle, JP; Cortijo, J; Curtis-Prior, PB; Davies, JM; Foster, RW; Hofer, P; Small, RC | 1 |
| Cortijo, J; Esplugues, J; Morcillo, EJ; Ortiz, JL; Perpiñá, M; Sanz, C | 1 |
| Whiting, SJ; Whitney, HL | 1 |
| Kusenbach, G; Reinhardt, D | 1 |
| Carlini, CR; Guimarães, JA; Ribeiro, JM | 1 |
| Palasz, M | 1 |
| Andersson, S | 1 |
| Nelemans, FA | 1 |
| Chvasta, TE; Cooke, AR | 1 |
| Gai, V; Gastaldi, L; Nattero, G | 2 |
| Hsiu, HC; Shih, TB; Wang, KT | 1 |
| Auclair, MC; Carli, A; Vernimmen, C | 1 |
| Alesse, E; Altamura, A; Cifone, MG; Conti, P; Continenza, MA; Ianni, G; Reale, H | 1 |
| Chernick, V; Ioffe, S; Jansen, AH | 1 |
| Aizawa, Y; Kogo, H; Takeuchi, K | 1 |
| Chowdhury, JU; Huang, SM; Pang, YW; Tomita, T; Tsugeno, M | 1 |
| Hatano, Y; Kakuyama, M; Mori, K; Nakamura, K; Nishiwada, M; Terasako, K; Toda, H | 1 |
| Fukuuchi, Y; Isozumi, K; Itoh, Y; Takeda, H | 1 |
| Berner, B; Camel, E; Maibach, H; Nangia, A | 1 |
| Anton, M; Cortijo, J; Morcillo, EJ; Sanz, CM; Villagrasa, V | 1 |
| Kang, BS; Lee, EY; Lee, HY; Lee, YH | 1 |
| Martin, GR; Reich, R | 1 |
| Khalil, RM | 1 |
| Hsiao, ML; Huang, WF; Wen, KC | 1 |
| Costa, G; García-Pascual, A; Jimenez, E; Labadía, A; Triguero, D | 1 |
| Benson, KA; Gunter-Smith, PJ; Hanson, WR; Hogan, JB; Landauer, MR; Neta, R; Weiss, JF | 1 |
| Biaggioni, I; Black, BK; Jordan, J; Norman, R; Robertson, D; Shannon, JR | 1 |
| Macdonald, RL; Marton, LS; Weir, B; Zhang, J | 1 |
| Cheuk, G; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Saltzman, MJ; Yazdani, M | 1 |
| Burg, MB; Ferguson, DR; Kirby, M; Michea, LF; Peters, EM; Rocha, GM; Xu, Y | 1 |
| Grbović, L; Pesić, S; Prostran, M; Radenković, M | 1 |
| Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C | 2 |
| Amann, R; Heinemann, A; Santner, B; Schuligoi, R; Ulcar, R | 1 |
| Aloisio, A; Del Bianco, P; Di Monda, V; Fonzari, M; Grazioli, I; Nicolodi, M; Sicuteri, F; Uslenghi, C; Vecchiet, L | 1 |
| Barros, AI; Campos, AR; Rao, VS; Santos, FA | 1 |
| Bendhack, LM; de Campos Grifoni, S | 1 |
| Jafari, M; Rabbani, A | 1 |
| Cao, YX; Edvinsson, L; He, JY; Li, J; Xu, CB; Zheng, JP | 1 |
| Centonze, V; Cerbo, R; Grazioli, I; Sternieri, E; Tavolato, B; Trenti, T; Uslenghi, C | 1 |
| Bertolini, A; Coccia, CP; Ferrari, A; Gallesi, D; Leone, S; Loi, M; Pasciullo, G; Pinetti, D; Sances, G; Savino, G; Sternieri, E | 1 |
| Clyman, RI; Roman, C | 1 |
| Cerbo, R; Del Bene, E; Ferrari, A; Genco, S; Grazioli, I; Martelletti, P; Nappi, G; Pinessi, L; Sandrini, G; Sarchielli, P; Tamburro, P; Uslenghi, C; Zanchin, G | 1 |
| Mett, A; Tfelt-Hansen, P | 1 |
| Araújo, JR; Gonçalves, P; Martel, F; Pinho, MJ | 1 |
| Gilani, AH; Shah, AJ | 1 |
| Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C; Vivoli, E | 1 |
| Dusitanond, P; Young, WB | 1 |
| Ferrante, E; Lisotto, C; Nappi, G; Rossi, P; Tassorelli, C | 1 |
| Alexander, SP; Randall, MD; Wheal, AJ | 1 |
| Holle, D; Obermann, M | 1 |
| Descamps, M; Guinet, Y; Hédoux, A | 1 |
| Hoy, SM; Scott, LJ | 1 |
| Kühne, S; Steinert, M; Untucht, C; Wätzig, H | 1 |
| Hirakura, Y; Terada, K; Teramura, T; Yamashita, H; Yuda, M | 1 |
| Mimura, H; Nasu, M; Nemoto, T; Sako, K | 1 |
| Basurto Ona, X; Bonfill Cosp, X; Martínez García, L; Solà, I; Uriona Tuma, SM | 1 |
| Patel, S | 1 |
| Alada, AR; Isehunwa, GO; Murtala, BA; Omoaghe, AO; Salahdeen, HM | 1 |
| Baraldi, C; Leuzzi, M; Patrizi, A; Savoia, F; Sechi, A; Tabanelli, M; Zago, S | 1 |
9 review(s) available for caffeine and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Hematemesis; Humans; Indomethacin; Nicotine; Occult Blood; Peptic Ulcer; Permeability; Phenylbutazone; Smoking; Stimulation, Chemical; Stomach Ulcer | 1976 |
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucocorticoids; Histamine; Humans; Hypoglycemic Agents; Indomethacin; Parasympathomimetics; Phenylbutazone; Quinolines; Reserpine; Stomach Ulcer | 1974 |
Acute migraine therapy: recent evidence from randomized comparative trials.
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Drug Therapy, Combination; Ergotamine; Humans; Indomethacin; Migraine Disorders; Prochlorperazine; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Treatment Outcome; Tryptamines; Vasoconstrictor Agents | 2008 |
Focus on therapy of hypnic headache.
Topics: Antimanic Agents; Caffeine; Flunarizine; Headache Disorders, Primary; Humans; Indomethacin; Lithium Compounds | 2010 |
Hypnic headache.
Topics: Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Cyclooxygenase Inhibitors; Headache Disorders, Primary; Humans; Indomethacin; Melatonin | 2010 |
Indomethacin/prochlorperazine/caffeine: a review of its use in the acute treatment of migraine and in the treatment of episodic tension-type headache.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Drug Combinations; Female; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Prochlorperazine; Tension-Type Headache; Young Adult | 2011 |
Drug therapy for preventing post-dural puncture headache.
Topics: Adult; Aminophylline; Analgesics; Caffeine; Child; Cosyntropin; Dexamethasone; Drug Administration Routes; Female; Fentanyl; Humans; Indomethacin; Male; Morphine; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture | 2013 |
Hypnic headache: a review of 2012 publications.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Female; Headache Disorders, Primary; Humans; Hyperbaric Oxygenation; Indomethacin; International Classification of Diseases; Male; Pain Measurement; Remission Induction; Sleep Disorders, Intrinsic; Treatment Outcome | 2013 |
6 trial(s) available for caffeine and indomethacin
| Article | Year |
|---|---|
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)].
Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, Combination; Ergotamine; Headache; Histamine; Humans; Indomethacin; Metergoline; Methysergide; Migraine Disorders; Pizotyline; Prochlorperazine; Reserpine; Retrospective Studies; Urea | 1975 |
Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Caffeine; Chronic Disease; Female; Humans; Hyperglycemia; Hypotension; Hypotension, Orthostatic; Indomethacin; Insulin Antagonists; Male; Middle Aged; Octreotide; Somatostatin; Time Factors | 1986 |
Contrasting actions of pressor agents in severe autonomic failure.
Topics: Aged; Autonomic Agents; Blood Pressure; Caffeine; Catecholamines; Female; Heart Rate; Humans; Hypotension, Orthostatic; Ibuprofen; Indomethacin; Male; Methylphenidate; Phenylpropanolamine; Regression Analysis; Single-Blind Method; Yohimbine | 1998 |
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Drug Combinations; Female; Humans; Indomethacin; Male; Migraine Disorders; Prochlorperazine; Recurrence; Research Design; Serotonin Receptor Agonists; Sumatriptan; Suppositories; Treatment Outcome | 2003 |
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine in the treatment of episodic tension-type headache: a double-blind, randomized, nimesulide-controlled, parallel group, multicentre trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Caffeine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Indomethacin; Male; Middle Aged; Pain Measurement; Prochlorperazine; Retrospective Studies; Sulfonamides; Tension-Type Headache; Time Factors; Treatment Outcome | 2005 |
Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, mu
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Prochlorperazine; Recurrence; Sumatriptan; Treatment Outcome | 2007 |
97 other study(ies) available for caffeine and indomethacin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Bacillus; Chromatography, High Pressure Liquid; Coumarins; Isocoumarins; Peptic Ulcer; Rats; Solubility; Structure-Activity Relationship | 1985 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Experimental ulcer].
Topics: Animals; Caffeine; Cats; Cattle; Chickens; Disease Models, Animal; Dogs; Ducks; Guinea Pigs; Haplorhini; Indomethacin; Mice; Peptic Ulcer; Phenylbutazone; Pilocarpine; Quinolines; Rabbits; Rats; Reserpine; Swine | 1975 |
Human placental cAMP phosphodiesterase activity kinetic properties and sensitivity to some drugs and hormones.
Topics: Caffeine; Cyclic AMP; Epinephrine; Estradiol; Female; Flufenamic Acid; Hormones; Humans; Imidazoles; Indomethacin; Insulin; Kinetics; Magnesium; Norepinephrine; Pharmacology; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Progesterone; Prostaglandins; Theophylline | 1975 |
The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclic 3',5'-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bucladesine; Caffeine; Depression, Chemical; Dipyridamole; Fatty Acids, Essential; Indomethacin; Papaverine; Phosphodiesterase Inhibitors; Platelet Aggregation; Rats | 1975 |
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Drug Synergism; Epinephrine; Female; Haplorhini; Indomethacin; Macaca mulatta; Myometrium; Phosphoric Diester Hydrolases; Pregnancy; Prostaglandins E; Theophylline; Uterine Contraction; Uterus | 1976 |
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation.
Topics: Angiotensin II; Animals; Caffeine; Drug Synergism; Female; Guinea Pigs; Ileum; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins E; Rats; Theophylline; Uterus; Xanthines | 1977 |
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; Myometrium; Papaverine; Placenta; Pregnancy; Pregnancy Trimester, Third; Theophylline; Uterus | 1977 |
Effect of prostaglandins on the increased corticosterone output induced by caffeine in the rat.
Topics: Adrenal Glands; Animals; Caffeine; Corticosterone; Cyclic AMP; Indomethacin; Male; Prostaglandins E, Synthetic; Rats | 1979 |
Polyunsaturated fatty acids, vitamin E, and the proliferation of aortic smooth muscle cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Antioxidants; Aorta; Caffeine; Cell Division; Fatty Acids, Unsaturated; Guinea Pigs; Indomethacin; Muscle, Smooth; Papaverine; Prostaglandins E; Prostaglandins F; Vitamin E | 1979 |
Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat.
Topics: Animals; Arthritis, Rheumatoid; Aspirin; Caffeine; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Indomethacin; Inflammation; Male; Phenylbutazone; Rats; Salicylates | 1976 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and Adverse Reactions; Ethanol; Humans; Indomethacin; Phenylbutazone; Reserpine; Smoking; Stomach Diseases; Stomach Ulcer | 1976 |
Perinatal pharmacology and cerebral blood flow.
Topics: Arteries; Blood Flow Velocity; Caffeine; Carbon Dioxide; Cerebrovascular Circulation; Drug Combinations; Fatty Alcohols; Humans; Indomethacin; Infant, Newborn; Partial Pressure; Phenobarbital; Phosphorylcholine; Polyethylene Glycols; Pulmonary Surfactants | 1992 |
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Theophylline | 1992 |
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea | 1991 |
A G-protein of sarcoplasmic reticulum of skeletal muscle is activated by caffeine or inositol trisphosphate.
Topics: Alprostadil; Animals; Caffeine; Calcium; GTP Phosphohydrolases; GTP-Binding Proteins; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscles; Phosphoric Monoester Hydrolases; Ranidae; Sarcoplasmic Reticulum; Sugar Phosphates | 1989 |
The relaxant and spasmogenic effects of some xanthine derivatives acting on guinea-pig isolated trachealis muscle.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Colforsin; Egtazic Acid; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Potassium Chloride; Temperature; Xanthines | 1988 |
The spasmogenic effect of caffeine in trachealis isolated from control and actively sensitized guinea-pigs.
Topics: Animals; Caffeine; Calcium; Dantrolene; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Temperature; Trachea; Trifluoperazine; Verapamil | 1988 |
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Inbred Strains; Theophylline; Time Factors | 1987 |
[Peculiarities of drug therapy in childhood].
Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; Drug Therapy; Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Receptors, Drug; Theophylline; Tissue Distribution | 1986 |
Platelet release reaction and aggregation induced by canatoxin, a convulsant protein: evidence for the involvement of the platelet lipoxygenase pathway.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adenosine Monophosphate; Animals; Arachidonate Lipoxygenases; Blood Platelets; Caffeine; Creatine Kinase; Drug Interactions; Edetic Acid; Epoprostenol; Guinea Pigs; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Lectins; Lipoxygenase; Phosphocreatine; Plant Proteins; Platelet Aggregation; Quinacrine; Rabbits; Species Specificity; Synaptosomes; Thrombin; Toxins, Biological | 1985 |
[Side effects of drugs. 2. Gastrointestinal side effects].
Topics: Adrenocorticotropic Hormone; Caffeine; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Diseases; Histamine; Humans; Indomethacin; Nicotinic Acids; Peptic Ulcer; Phenylbutazone; Reserpine; Salicylates | 1969 |
[Analgesics in dentistry].
Topics: Acetanilides; Agranulocytosis; Analgesics; Anesthesia, Dental; Aspirin; Blood Coagulation; Caffeine; Codeine; Drug Combinations; Flufenamic Acid; Gastrointestinal Hemorrhage; Heterocyclic Compounds; Humans; Indomethacin; Mefenamic Acid; Morphinans; Mouth Diseases; ortho-Aminobenzoates; Phenacetin | 1972 |
The effect of several ulcerogenic drugs on the canine gastric mucosal barrier.
Topics: Animals; Caffeine; Cell Membrane Permeability; Cortisone; Dogs; Female; Gastric Mucosa; Hydrocortisone; Hydrogen-Ion Concentration; Indomethacin; Ion Exchange; Membrane Potentials; Phenylbutazone; Potassium Chloride; Sodium Chloride | 1972 |
[Study of a test of active headache extinction].
Topics: Caffeine; Diagnosis, Differential; Headache; Humans; Indomethacin; Migraine Disorders; Prochlorperazine; Vascular Headaches | 1968 |
[Changes in hemodynamics observed during the extinction phase of headache attacks].
Topics: Blood Pressure; Brachial Artery; Caffeine; Headache; Hemodynamics; Humans; Indomethacin; Migraine Disorders; Ophthalmic Artery; Plethysmography, Impedance; Prochlorperazine; Temporal Arteries; Vascular Headaches; Vertebral Artery | 1968 |
Polyamide layer chromatography of some antipyretics.
Topics: Acetanilides; Amides; Aminopyrine; Analgesics; Antipyrine; Aspirin; Caffeine; Chromatography, Thin Layer; Indomethacin; Oxyphenbutazone; Phenacetin; Salicylates | 1969 |
Indomethacin suppresses the early cardiodepressant factor released by endotoxin in the rat: possible involvement of a prostacyclin-related material.
Topics: Animals; Caffeine; Cells, Cultured; Depression, Chemical; Epoprostenol; Imidazoles; Indomethacin; Male; Myocardial Contraction; Myocardial Depressant Factor; Nifedipine; Peptide Biosynthesis; Rats; Shock, Septic | 1983 |
[Effect of the association of caffeine-indomethacin on the production of prostacyclin in the rat stomach].
Topics: Animals; Caffeine; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains; Stomach | 1982 |
Drug-induced changes in fetal breathing activity and sleep state.
Topics: Animals; Caffeine; Doxapram; Female; Fetus; Indomethacin; Pilocarpine; Pregnancy; Respiration; Sheep; Sleep; Sodium Cyanide | 1983 |
Effects of methylxanthines on urinary prostaglandin E excretion in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electrolytes; Indomethacin; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1981 |
Sustained contraction produced by caffeine after ryanodine treatment in the circular muscle of the guinea-pig gastric antrum and rabbit portal vein.
Topics: Animals; Caffeine; Calcium; Carbachol; Colforsin; Female; Fura-2; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Portal Vein; Pyloric Antrum; Rabbits; Ryanodine | 1995 |
Halothane and enflurane constrict canine mesenteric arteries by releasing Ca2+ from intracellular Ca2+ stores.
Topics: Animals; Arginine; Caffeine; Calcium; Dogs; Enflurane; Fluorescent Dyes; Fura-2; Halothane; In Vitro Techniques; Indomethacin; Isometric Contraction; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitroarginine; Ryanodine; Spectrometry, Fluorescence; Vasoconstriction | 1994 |
Mechanisms of CBF augmentation during hypoxia in cats: probable participation of prostacyclin, nitric oxide and adenosine.
Topics: Adenosine; Animals; Arginine; Caffeine; Cats; Cerebrovascular Circulation; Epoprostenol; Hypoxia; Indomethacin; Nitric Oxide; omega-N-Methylarginine | 1994 |
Influence of skin irritants on percutaneous absorption.
Topics: Adult; Caffeine; Humans; Hydrocortisone; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Irritants; Male; Phenylpropanolamine; Skin; Skin Absorption; Water Loss, Insensible | 1993 |
Pharmacological modulation of the spasmogenic response to methylxanthines in guinea-pig trachea.
Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Protein Kinase C; Sodium; Theophylline; Trachea; Xanthines | 1993 |
Hypoxic contraction of isolated rat pulmonary artery.
Topics: Animals; Caffeine; Cell Hypoxia; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Nifedipine; Nitric Oxide; Oxygen; Pulmonary Artery; Rats; Vasoconstriction; Vasodilator Agents | 1995 |
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Topics: Animals; Arachidonic Acid; Caffeine; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Drug Combinations; Extracellular Matrix; Fibrosarcoma; Gelatinases; Humans; Indoles; Indomethacin; Laminin; Leukotrienes; Lipoxygenase Inhibitors; Masoprocol; Matrix Metalloproteinase 2; Melanoma; Metalloendopeptidases; Mice; Neoplasm Metastasis; Proteoglycans; Tumor Cells, Cultured; Umbelliferones | 1996 |
Interaction of ibuprofen and indomethacin with caffeine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Chemical Phenomena; Chemistry, Physical; Ibuprofen; Indomethacin; Male; Rats; Skin Absorption; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1996 |
Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan.
Topics: Acetaminophen; Caffeine; Drug Contamination; Drugs, Chinese Herbal; Indomethacin; Taiwan | 1997 |
Endothelin receptor-mediated Ca2+ mobilization and contraction in bovine oviductal arteries: comparison with noradrenaline and potassium.
Topics: Animals; Cadmium; Caffeine; Calcium; Calcium Channel Agonists; Cattle; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelium, Vascular; Fallopian Tubes; Female; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Nickel; Nifedipine; Nitroarginine; Norepinephrine; Peptides, Cyclic; Potassium; Receptors, Endothelin; Ryanodine; Viper Venoms | 1997 |
Modification of radiation-induced gastrointestinal and hematopoietic injury in mice by combinations of agents: effects of indomethacin and caffeine.
Topics: Amifostine; Animals; Caffeine; Cobalt Radioisotopes; Digestive System; Drug Interactions; Gamma Rays; Hematopoiesis; Indomethacin; Interleukin-1; Male; Mice; Mice, Inbred Strains; Radiation-Protective Agents; Survival Rate | 1997 |
Effects of cell-permeant calcium chelators on contractility in monkey basilar artery.
Topics: Animals; Basilar Artery; Caffeine; Calcium; Chelating Agents; Dinoprost; Dogs; Egtazic Acid; Endothelium; In Vitro Techniques; Indomethacin; Macaca fascicularis; Muscle Contraction; Muscle, Smooth, Vascular; Oxyhemoglobins; Potassium Chloride; Vasoconstriction | 1999 |
Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Osteoblasts; Periodontitis; Phosphodiesterase Inhibitors; Rats; Risk Factors; Time Factors | 1999 |
Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caffeine; Cell Division; Cell Line; Cyclooxygenase Inhibitors; Drug Interactions; Flow Cytometry; Indomethacin; Kidney Tubules, Collecting; Mice; Microscopy, Electron; Salicylic Acid | 2001 |
Characterization of adenosine action in isolated rat renal artery. Possible role of adenosine A(2A) receptors.
Topics: Adenosine; Animals; Caffeine; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Isotonic Solutions; Male; Models, Animal; Muscle Relaxation; Nitroarginine; Potassium Chloride; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery; Tetraethylammonium; Vasodilator Agents; Xanthines | 2000 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug Combinations; Hyperalgesia; Indomethacin; Male; Mice; Migraine Disorders; Morphine; Prochlorperazine; Substance Withdrawal Syndrome; Time Factors | 2002 |
Inhibition of prostaglandin biosynthesis in human endotoxin-stimulated peripheral blood monocytes: effects of caffeine.
Topics: Caffeine; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin-Endoperoxide Synthases; Statistics, Nonparametric | 2003 |
Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Caffeine; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Motility; Indomethacin; Male; Mice; Paullinia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Stomach Ulcer | 2003 |
Functional study of the [Ca2+]i signaling pathway in aortas of L-NAME-hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Caffeine; Calcium; Calcium Signaling; Disease Models, Animal; Drug Synergism; Endothelium, Vascular; Hypertension; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenylephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Time Factors; Tunica Intima; Vasoconstriction | 2004 |
Studies on the mechanism of caffeine action in alveolar macrophages: caffeine elevates cyclic adenosine monophosphate level and prostaglandin synthesis.
Topics: Animals; Caffeine; Cell Survival; Cyclic AMP; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomethacin; Macrophages, Alveolar; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Sprague-Dawley; Superoxides | 2004 |
Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine.
Topics: Animals; Caffeine; Disease Models, Animal; Drug Therapy, Combination; Indomethacin; Male; Mice; Migraine Disorders; Pain Measurement; Peripheral Nerves; Prochlorperazine; Sumatriptan; Trigeminal Nerve | 2004 |
Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca(2+)-influx and Ca(2+)-release.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Caffeine; Calcium; Calcium Chloride; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Ion Transport; Membrane Potentials; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilation | 2005 |
Effect of overuse of the antimigraine combination of indomethacin, prochlorperazine and caffeine (IPC) on the disposition of its components in chronic headache patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Area Under Curve; Caffeine; Central Nervous System Stimulants; Chronic Disease; Drug Combinations; Female; Half-Life; Headache Disorders; Headache Disorders, Secondary; Humans; Indomethacin; Middle Aged; Prochlorperazine; Time Factors | 2006 |
The effects of caffeine on the preterm sheep ductus arteriosus.
Topics: Animals; Caffeine; Cardiovascular Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arteriosus; Ductus Arteriosus, Patent; Female; Gestational Age; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Pregnancy; Prostaglandins; Sheep; Vasoconstriction | 2007 |
Modulation of butyrate transport in Caco-2 cells.
Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetaldehyde; Acids, Acyclic; Aspirin; Biological Transport, Active; Butyrates; Caco-2 Cells; Caffeine; Cell Survival; Dronabinol; Gene Expression; Humans; Hydrogen-Ion Concentration; Indomethacin; Ions; Kinetics; Monocarboxylic Acid Transporters; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Azide; Symporters; Theophylline | 2009 |
Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.
Topics: Acetylcholine; Acorus; Animals; Aorta, Thoracic; Atropine; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Indomethacin; Inhibitory Concentration 50; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Phenylephrine; Plant Extracts; Plant Roots; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reference Standards; Ryanodine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil | 2009 |
The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Caffeine; Central Nervous System Stimulants; Cerebral Arteries; Disease Models, Animal; Dopamine Antagonists; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; GTP-Binding Protein alpha Subunits, Gi-Go; Indomethacin; Male; Mice; Migraine Disorders; Prochlorperazine; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome | 2009 |
Neuroleptics and migraine.
Topics: Antipsychotic Agents; Benzodiazepines; Brain; Caffeine; Dibenzothiazepines; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Female; Humans; Hyperprolactinemia; Indomethacin; Male; Migraine Disorders; Neural Pathways; Olanzapine; Prochlorperazine; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Treatment Outcome | 2009 |
Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity.
Topics: Animals; Aorta, Thoracic; Arachidonic Acids; Caffeine; Capsaicin; Chloride Channels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Vasodilation | 2010 |
The contribution of Raman spectroscopy to the analysis of phase transformations in pharmaceutical compounds.
Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Indomethacin; Pharmaceutical Preparations; Phase Transition; Povidone; Spectrum Analysis, Raman | 2011 |
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution | 2012 |
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction | 2013 |
Development of qualitative and quantitative analysis methods in pharmaceutical application with new selective signal excitation methods for 13 C solid-state nuclear magnetic resonance using 1 H T1rho relaxation time.
Topics: Acetaminophen; Antipyrine; beta-Cyclodextrins; Caffeine; Carbon Isotopes; Chemistry, Pharmaceutical; Crystallization; Drug Combinations; Excipients; Indomethacin; Lactose; Magnetic Resonance Spectroscopy; Nifedipine; Pharmaceutical Preparations; Phenacetin; Povidone; Protons; Pyridones; Signal Processing, Computer-Assisted; Technology, Pharmaceutical | 2013 |
Effects of chronic administration of ethanolic extract of kolanut (Cola nitida) and caffeine on vascular function.
Topics: Acetylcholine; Animals; Aorta; Atropine; Blood Pressure; Caffeine; Cola; Dose-Response Relationship, Drug; Ethanol; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Plant Extracts; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Weight Gain | 2014 |
Multiple perianal ulcers due to suppositories.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anus Diseases; Caffeine; Central Nervous System Stimulants; Chronic Disease; Dopamine Antagonists; Drug Combinations; Female; Humans; Indomethacin; Prochlorperazine; Skin Ulcer; Suppositories | 2019 |