caffeine and indomethacin

caffeine has been researched along with indomethacin in 112 studies

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-199032 (28.57)18.7374
1990's17 (15.18)18.2507
2000's34 (30.36)29.6817
2010's29 (25.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Baba, T; Hayashi, H; Shimojima, Y; Shirai, T1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Faassen, F; Spanings, H; Vogel, G; Vromans, H1
Jolivette, LJ; Ward, KW1
Carrupt, PA; Martel, S; Ottaviani, G2
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Conradi, R; Lee, PH; Shanmugasundaram, V1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Sen, S; Sinha, N1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Varró, V1
Breuiller, M; Cedard, L; Ferre, F1
Bonta, IL; Vincent, JE; Zijlstra, FJ1
Beatty, CH; Bocek, RM; Novy, MJ; Young, MK1
Franks, DJ; Hamet, P; Horrobin, DF; Manku, MS1
Breuiller, M; Cedard, L; de Pariente, D; Ferre, F1
Ceserani, R; Costa, G; De Pasquale, A; Trovato, A1
Cornwell, DG; Geer, JC; Huttner, JJ; Milo, GE; Panganamala, RV; Sharma, HM1
Cooke, AR2
Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G1
Ellis, CH; Selph, JL; Truax, JF; Vinegar, R; Welch, RM; White, HL1
Autret, E; Laugier, J; Nasr, C; Saliba, E; Suc, AL1
Lerner, UH; Mellström, D1
Cortijo, J; Morcillo, EJ; Ortiz, JL; Sanz, CM1
Hasegawa, T; Kumagai, S1
Boden, G; Hoeldtke, RD; O'Dorisio, TM1
Boyle, JP; Cortijo, J; Curtis-Prior, PB; Davies, JM; Foster, RW; Hofer, P; Small, RC1
Cortijo, J; Esplugues, J; Morcillo, EJ; Ortiz, JL; Perpiñá, M; Sanz, C1
Whiting, SJ; Whitney, HL1
Kusenbach, G; Reinhardt, D1
Carlini, CR; Guimarães, JA; Ribeiro, JM1
Palasz, M1
Andersson, S1
Nelemans, FA1
Chvasta, TE; Cooke, AR1
Gai, V; Gastaldi, L; Nattero, G2
Hsiu, HC; Shih, TB; Wang, KT1
Auclair, MC; Carli, A; Vernimmen, C1
Alesse, E; Altamura, A; Cifone, MG; Conti, P; Continenza, MA; Ianni, G; Reale, H1
Chernick, V; Ioffe, S; Jansen, AH1
Aizawa, Y; Kogo, H; Takeuchi, K1
Chowdhury, JU; Huang, SM; Pang, YW; Tomita, T; Tsugeno, M1
Hatano, Y; Kakuyama, M; Mori, K; Nakamura, K; Nishiwada, M; Terasako, K; Toda, H1
Fukuuchi, Y; Isozumi, K; Itoh, Y; Takeda, H1
Berner, B; Camel, E; Maibach, H; Nangia, A1
Anton, M; Cortijo, J; Morcillo, EJ; Sanz, CM; Villagrasa, V1
Kang, BS; Lee, EY; Lee, HY; Lee, YH1
Martin, GR; Reich, R1
Khalil, RM1
Hsiao, ML; Huang, WF; Wen, KC1
Costa, G; García-Pascual, A; Jimenez, E; Labadía, A; Triguero, D1
Benson, KA; Gunter-Smith, PJ; Hanson, WR; Hogan, JB; Landauer, MR; Neta, R; Weiss, JF1
Biaggioni, I; Black, BK; Jordan, J; Norman, R; Robertson, D; Shannon, JR1
Macdonald, RL; Marton, LS; Weir, B; Zhang, J1
Cheuk, G; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Saltzman, MJ; Yazdani, M1
Burg, MB; Ferguson, DR; Kirby, M; Michea, LF; Peters, EM; Rocha, GM; Xu, Y1
Grbović, L; Pesić, S; Prostran, M; Radenković, M1
Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C2
Amann, R; Heinemann, A; Santner, B; Schuligoi, R; Ulcar, R1
Aloisio, A; Del Bianco, P; Di Monda, V; Fonzari, M; Grazioli, I; Nicolodi, M; Sicuteri, F; Uslenghi, C; Vecchiet, L1
Barros, AI; Campos, AR; Rao, VS; Santos, FA1
Bendhack, LM; de Campos Grifoni, S1
Jafari, M; Rabbani, A1
Cao, YX; Edvinsson, L; He, JY; Li, J; Xu, CB; Zheng, JP1
Centonze, V; Cerbo, R; Grazioli, I; Sternieri, E; Tavolato, B; Trenti, T; Uslenghi, C1
Bertolini, A; Coccia, CP; Ferrari, A; Gallesi, D; Leone, S; Loi, M; Pasciullo, G; Pinetti, D; Sances, G; Savino, G; Sternieri, E1
Clyman, RI; Roman, C1
Cerbo, R; Del Bene, E; Ferrari, A; Genco, S; Grazioli, I; Martelletti, P; Nappi, G; Pinessi, L; Sandrini, G; Sarchielli, P; Tamburro, P; Uslenghi, C; Zanchin, G1
Mett, A; Tfelt-Hansen, P1
Araújo, JR; Gonçalves, P; Martel, F; Pinho, MJ1
Gilani, AH; Shah, AJ1
Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C; Vivoli, E1
Dusitanond, P; Young, WB1
Ferrante, E; Lisotto, C; Nappi, G; Rossi, P; Tassorelli, C1
Alexander, SP; Randall, MD; Wheal, AJ1
Holle, D; Obermann, M1
Descamps, M; Guinet, Y; Hédoux, A1
Hoy, SM; Scott, LJ1
Kühne, S; Steinert, M; Untucht, C; Wätzig, H1
Hirakura, Y; Terada, K; Teramura, T; Yamashita, H; Yuda, M1
Mimura, H; Nasu, M; Nemoto, T; Sako, K1
Basurto Ona, X; Bonfill Cosp, X; Martínez García, L; Solà, I; Uriona Tuma, SM1
Patel, S1
Alada, AR; Isehunwa, GO; Murtala, BA; Omoaghe, AO; Salahdeen, HM1
Baraldi, C; Leuzzi, M; Patrizi, A; Savoia, F; Sechi, A; Tabanelli, M; Zago, S1

Reviews

9 review(s) available for caffeine and indomethacin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
    The American journal of digestive diseases, 1976, Volume: 21, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Hematemesis; Humans; Indomethacin; Nicotine; Occult Blood; Peptic Ulcer; Permeability; Phenylbutazone; Smoking; Stimulation, Chemical; Stomach Ulcer

1976
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1974, Jun-15, Volume: 27, Issue:12

    Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucocorticoids; Histamine; Humans; Hypoglycemic Agents; Indomethacin; Parasympathomimetics; Phenylbutazone; Quinolines; Reserpine; Stomach Ulcer

1974
Acute migraine therapy: recent evidence from randomized comparative trials.
    Current opinion in neurology, 2008, Volume: 21, Issue:3

    Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Drug Therapy, Combination; Ergotamine; Humans; Indomethacin; Migraine Disorders; Prochlorperazine; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Treatment Outcome; Tryptamines; Vasoconstrictor Agents

2008
Focus on therapy of hypnic headache.
    The journal of headache and pain, 2010, Volume: 11, Issue:4

    Topics: Antimanic Agents; Caffeine; Flunarizine; Headache Disorders, Primary; Humans; Indomethacin; Lithium Compounds

2010
Hypnic headache.
    Expert review of neurotherapeutics, 2010, Volume: 10, Issue:9

    Topics: Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Cyclooxygenase Inhibitors; Headache Disorders, Primary; Humans; Indomethacin; Melatonin

2010
Indomethacin/prochlorperazine/caffeine: a review of its use in the acute treatment of migraine and in the treatment of episodic tension-type headache.
    CNS drugs, 2011, Volume: 25, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Drug Combinations; Female; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Prochlorperazine; Tension-Type Headache; Young Adult

2011
Drug therapy for preventing post-dural puncture headache.
    The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2

    Topics: Adult; Aminophylline; Analgesics; Caffeine; Child; Cosyntropin; Dexamethasone; Drug Administration Routes; Female; Fentanyl; Humans; Indomethacin; Male; Morphine; Post-Dural Puncture Headache; Randomized Controlled Trials as Topic; Spinal Puncture

2013
Hypnic headache: a review of 2012 publications.
    Current pain and headache reports, 2013, Volume: 17, Issue:7

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Female; Headache Disorders, Primary; Humans; Hyperbaric Oxygenation; Indomethacin; International Classification of Diseases; Male; Pain Measurement; Remission Induction; Sleep Disorders, Intrinsic; Treatment Outcome

2013

Trials

6 trial(s) available for caffeine and indomethacin

ArticleYear
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1975, Sep-19, Volume: 117, Issue:38

    Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, Combination; Ergotamine; Headache; Histamine; Humans; Indomethacin; Metergoline; Methysergide; Migraine Disorders; Pizotyline; Prochlorperazine; Reserpine; Retrospective Studies; Urea

1975
Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995.
    Lancet (London, England), 1986, Sep-13, Volume: 2, Issue:8507

    Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Caffeine; Chronic Disease; Female; Humans; Hyperglycemia; Hypotension; Hypotension, Orthostatic; Indomethacin; Insulin Antagonists; Male; Middle Aged; Octreotide; Somatostatin; Time Factors

1986
Contrasting actions of pressor agents in severe autonomic failure.
    The American journal of medicine, 1998, Volume: 105, Issue:2

    Topics: Aged; Autonomic Agents; Blood Pressure; Caffeine; Catecholamines; Female; Heart Rate; Humans; Hypotension, Orthostatic; Ibuprofen; Indomethacin; Male; Methylphenidate; Phenylpropanolamine; Regression Analysis; Single-Blind Method; Yohimbine

1998
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial.
    Headache, 2003, Volume: 43, Issue:8

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Drug Combinations; Female; Humans; Indomethacin; Male; Migraine Disorders; Prochlorperazine; Recurrence; Research Design; Serotonin Receptor Agonists; Sumatriptan; Suppositories; Treatment Outcome

2003
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine in the treatment of episodic tension-type headache: a double-blind, randomized, nimesulide-controlled, parallel group, multicentre trial.
    European journal of neurology, 2005, Volume: 12, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Caffeine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Indomethacin; Male; Middle Aged; Pain Measurement; Prochlorperazine; Retrospective Studies; Sulfonamides; Tension-Type Headache; Time Factors; Treatment Outcome

2005
Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, mu
    International journal of clinical practice, 2007, Volume: 61, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Analgesics; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Prochlorperazine; Recurrence; Sumatriptan; Treatment Outcome

2007

Other Studies

97 other study(ies) available for caffeine and indomethacin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Bacillus; Chromatography, High Pressure Liquid; Coumarins; Isocoumarins; Peptic Ulcer; Rats; Solubility; Structure-Activity Relationship

1985
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
    International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport

2003
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
    Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13

    Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water

2006
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Glutathione; Pharmacology; Sulfur Radioisotopes

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Experimental ulcer].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1975, Oct-01, Volume: 30, Issue:19

    Topics: Animals; Caffeine; Cats; Cattle; Chickens; Disease Models, Animal; Dogs; Ducks; Guinea Pigs; Haplorhini; Indomethacin; Mice; Peptic Ulcer; Phenylbutazone; Pilocarpine; Quinolines; Rabbits; Rats; Reserpine; Swine

1975
Human placental cAMP phosphodiesterase activity kinetic properties and sensitivity to some drugs and hormones.
    FEBS letters, 1975, Apr-01, Volume: 52, Issue:2

    Topics: Caffeine; Cyclic AMP; Epinephrine; Estradiol; Female; Flufenamic Acid; Hormones; Humans; Imidazoles; Indomethacin; Insulin; Kinetics; Magnesium; Norepinephrine; Pharmacology; Phosphoric Diester Hydrolases; Placenta; Pregnancy; Progesterone; Prostaglandins; Theophylline

1975
The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclic 3',5'-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats.
    Prostaglandins, 1975, Volume: 10, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bucladesine; Caffeine; Depression, Chemical; Dipyridamole; Fatty Acids, Essential; Indomethacin; Papaverine; Phosphodiesterase Inhibitors; Platelet Aggregation; Rats

1975
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys.
    Prostaglandins, 1976, Volume: 11, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Drug Synergism; Epinephrine; Female; Haplorhini; Indomethacin; Macaca mulatta; Myometrium; Phosphoric Diester Hydrolases; Pregnancy; Prostaglandins E; Theophylline; Uterine Contraction; Uterus

1976
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation.
    Prostaglandins, 1977, Volume: 13, Issue:1

    Topics: Angiotensin II; Animals; Caffeine; Drug Synergism; Female; Guinea Pigs; Ileum; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Perfusion; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins E; Rats; Theophylline; Uterus; Xanthines

1977
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Jul-04, Volume: 285, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; Myometrium; Papaverine; Placenta; Pregnancy; Pregnancy Trimester, Third; Theophylline; Uterus

1977
Effect of prostaglandins on the increased corticosterone output induced by caffeine in the rat.
    Prostaglandins and medicine, 1979, Volume: 3, Issue:2

    Topics: Adrenal Glands; Animals; Caffeine; Corticosterone; Cyclic AMP; Indomethacin; Male; Prostaglandins E, Synthetic; Rats

1979
Polyunsaturated fatty acids, vitamin E, and the proliferation of aortic smooth muscle cells.
    Lipids, 1979, Volume: 14, Issue:2

    Topics: 5,8,11,14-Eicosatetraynoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Antioxidants; Aorta; Caffeine; Cell Division; Fatty Acids, Unsaturated; Guinea Pigs; Indomethacin; Muscle, Smooth; Papaverine; Prostaglandins E; Prostaglandins F; Vitamin E

1979
Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Aspirin; Caffeine; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Indomethacin; Inflammation; Male; Phenylbutazone; Rats; Salicylates

1976
Drugs and gastric damage.
    Drugs, 1976, Volume: 11, Issue:1

    Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and Adverse Reactions; Ethanol; Humans; Indomethacin; Phenylbutazone; Reserpine; Smoking; Stomach Diseases; Stomach Ulcer

1976
Perinatal pharmacology and cerebral blood flow.
    Biology of the neonate, 1992, Volume: 62, Issue:4

    Topics: Arteries; Blood Flow Velocity; Caffeine; Carbon Dioxide; Cerebrovascular Circulation; Drug Combinations; Fatty Alcohols; Humans; Indomethacin; Infant, Newborn; Partial Pressure; Phenobarbital; Phosphorylcholine; Polyethylene Glycols; Pulmonary Surfactants

1992
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
    Calcified tissue international, 1992, Volume: 51, Issue:6

    Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relationship, Drug; Flurbiprofen; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Theophylline

1992
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
    European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3

    Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Theophylline; Trachea

1991
A G-protein of sarcoplasmic reticulum of skeletal muscle is activated by caffeine or inositol trisphosphate.
    FEBS letters, 1989, Feb-27, Volume: 244, Issue:2

    Topics: Alprostadil; Animals; Caffeine; Calcium; GTP Phosphohydrolases; GTP-Binding Proteins; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscles; Phosphoric Monoester Hydrolases; Ranidae; Sarcoplasmic Reticulum; Sugar Phosphates

1989
The relaxant and spasmogenic effects of some xanthine derivatives acting on guinea-pig isolated trachealis muscle.
    British journal of pharmacology, 1988, Volume: 94, Issue:4

    Topics: Acetylcholine; Animals; Caffeine; Calcium; Colforsin; Egtazic Acid; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Potassium Chloride; Temperature; Xanthines

1988
The spasmogenic effect of caffeine in trachealis isolated from control and actively sensitized guinea-pigs.
    European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3

    Topics: Animals; Caffeine; Calcium; Dantrolene; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Temperature; Trachea; Trifluoperazine; Verapamil

1988
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
    The Journal of nutrition, 1987, Volume: 117, Issue:7

    Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; Rats; Rats, Inbred Strains; Theophylline; Time Factors

1987
[Peculiarities of drug therapy in childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:11

    Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; Drug Therapy; Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature, Diseases; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Receptors, Drug; Theophylline; Tissue Distribution

1986
Platelet release reaction and aggregation induced by canatoxin, a convulsant protein: evidence for the involvement of the platelet lipoxygenase pathway.
    British journal of pharmacology, 1985, Volume: 84, Issue:2

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Adenosine Monophosphate; Animals; Arachidonate Lipoxygenases; Blood Platelets; Caffeine; Creatine Kinase; Drug Interactions; Edetic Acid; Epoprostenol; Guinea Pigs; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Lectins; Lipoxygenase; Phosphocreatine; Plant Proteins; Platelet Aggregation; Quinacrine; Rabbits; Species Specificity; Synaptosomes; Thrombin; Toxins, Biological

1985
[Side effects of drugs. 2. Gastrointestinal side effects].
    Lakartidningen, 1969, Dec-15, Volume: 66

    Topics: Adrenocorticotropic Hormone; Caffeine; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Diseases; Histamine; Humans; Indomethacin; Nicotinic Acids; Peptic Ulcer; Phenylbutazone; Reserpine; Salicylates

1969
[Analgesics in dentistry].
    Nederlands tijdschrift voor tandheelkunde, 1972, Volume: 79, Issue:2

    Topics: Acetanilides; Agranulocytosis; Analgesics; Anesthesia, Dental; Aspirin; Blood Coagulation; Caffeine; Codeine; Drug Combinations; Flufenamic Acid; Gastrointestinal Hemorrhage; Heterocyclic Compounds; Humans; Indomethacin; Mefenamic Acid; Morphinans; Mouth Diseases; ortho-Aminobenzoates; Phenacetin

1972
The effect of several ulcerogenic drugs on the canine gastric mucosal barrier.
    The Journal of laboratory and clinical medicine, 1972, Volume: 79, Issue:2

    Topics: Animals; Caffeine; Cell Membrane Permeability; Cortisone; Dogs; Female; Gastric Mucosa; Hydrocortisone; Hydrogen-Ion Concentration; Indomethacin; Ion Exchange; Membrane Potentials; Phenylbutazone; Potassium Chloride; Sodium Chloride

1972
[Study of a test of active headache extinction].
    Rivista critica di clinica medica, 1968, Volume: 68, Issue:4

    Topics: Caffeine; Diagnosis, Differential; Headache; Humans; Indomethacin; Migraine Disorders; Prochlorperazine; Vascular Headaches

1968
[Changes in hemodynamics observed during the extinction phase of headache attacks].
    Rivista critica di clinica medica, 1968, Volume: 68

    Topics: Blood Pressure; Brachial Artery; Caffeine; Headache; Hemodynamics; Humans; Indomethacin; Migraine Disorders; Ophthalmic Artery; Plethysmography, Impedance; Prochlorperazine; Temporal Arteries; Vascular Headaches; Vertebral Artery

1968
Polyamide layer chromatography of some antipyretics.
    Journal of chromatography, 1969, May-20, Volume: 41, Issue:3

    Topics: Acetanilides; Amides; Aminopyrine; Analgesics; Antipyrine; Aspirin; Caffeine; Chromatography, Thin Layer; Indomethacin; Oxyphenbutazone; Phenacetin; Salicylates

1969
Indomethacin suppresses the early cardiodepressant factor released by endotoxin in the rat: possible involvement of a prostacyclin-related material.
    Advances in shock research, 1983, Volume: 10

    Topics: Animals; Caffeine; Cells, Cultured; Depression, Chemical; Epoprostenol; Imidazoles; Indomethacin; Male; Myocardial Contraction; Myocardial Depressant Factor; Nifedipine; Peptide Biosynthesis; Rats; Shock, Septic

1983
[Effect of the association of caffeine-indomethacin on the production of prostacyclin in the rat stomach].
    Bollettino della Societa italiana di biologia sperimentale, 1982, Dec-30, Volume: 58, Issue:24

    Topics: Animals; Caffeine; Epoprostenol; Gastric Mucosa; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains; Stomach

1982
Drug-induced changes in fetal breathing activity and sleep state.
    Canadian journal of physiology and pharmacology, 1983, Volume: 61, Issue:4

    Topics: Animals; Caffeine; Doxapram; Female; Fetus; Indomethacin; Pilocarpine; Pregnancy; Respiration; Sheep; Sleep; Sodium Cyanide

1983
Effects of methylxanthines on urinary prostaglandin E excretion in rats.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:2

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electrolytes; Indomethacin; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1981
Sustained contraction produced by caffeine after ryanodine treatment in the circular muscle of the guinea-pig gastric antrum and rabbit portal vein.
    British journal of pharmacology, 1995, Volume: 114, Issue:7

    Topics: Animals; Caffeine; Calcium; Carbachol; Colforsin; Female; Fura-2; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Portal Vein; Pyloric Antrum; Rabbits; Ryanodine

1995
Halothane and enflurane constrict canine mesenteric arteries by releasing Ca2+ from intracellular Ca2+ stores.
    Anesthesiology, 1994, Volume: 80, Issue:5

    Topics: Animals; Arginine; Caffeine; Calcium; Dogs; Enflurane; Fluorescent Dyes; Fura-2; Halothane; In Vitro Techniques; Indomethacin; Isometric Contraction; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitroarginine; Ryanodine; Spectrometry, Fluorescence; Vasoconstriction

1994
Mechanisms of CBF augmentation during hypoxia in cats: probable participation of prostacyclin, nitric oxide and adenosine.
    The Keio journal of medicine, 1994, Volume: 43, Issue:1

    Topics: Adenosine; Animals; Arginine; Caffeine; Cats; Cerebrovascular Circulation; Epoprostenol; Hypoxia; Indomethacin; Nitric Oxide; omega-N-Methylarginine

1994
Influence of skin irritants on percutaneous absorption.
    Pharmaceutical research, 1993, Volume: 10, Issue:12

    Topics: Adult; Caffeine; Humans; Hydrocortisone; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Irritants; Male; Phenylpropanolamine; Skin; Skin Absorption; Water Loss, Insensible

1993
Pharmacological modulation of the spasmogenic response to methylxanthines in guinea-pig trachea.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 79, Issue:1

    Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Protein Kinase C; Sodium; Theophylline; Trachea; Xanthines

1993
Hypoxic contraction of isolated rat pulmonary artery.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 1995, Volume: 31, Issue:6

    Topics: Animals; Caffeine; Cell Hypoxia; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Nifedipine; Nitric Oxide; Oxygen; Pulmonary Artery; Rats; Vasoconstriction; Vasodilator Agents

1995
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
    Prostaglandins, 1996, Volume: 51, Issue:1

    Topics: Animals; Arachidonic Acid; Caffeine; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Drug Combinations; Extracellular Matrix; Fibrosarcoma; Gelatinases; Humans; Indoles; Indomethacin; Laminin; Leukotrienes; Lipoxygenase Inhibitors; Masoprocol; Matrix Metalloproteinase 2; Melanoma; Metalloendopeptidases; Mice; Neoplasm Metastasis; Proteoglycans; Tumor Cells, Cultured; Umbelliferones

1996
Interaction of ibuprofen and indomethacin with caffeine.
    Die Pharmazie, 1996, Volume: 51, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Chemical Phenomena; Chemistry, Physical; Ibuprofen; Indomethacin; Male; Rats; Skin Absorption; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

1996
Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:4

    Topics: Acetaminophen; Caffeine; Drug Contamination; Drugs, Chinese Herbal; Indomethacin; Taiwan

1997
Endothelin receptor-mediated Ca2+ mobilization and contraction in bovine oviductal arteries: comparison with noradrenaline and potassium.
    General pharmacology, 1997, Volume: 29, Issue:4

    Topics: Animals; Cadmium; Caffeine; Calcium; Calcium Channel Agonists; Cattle; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelium, Vascular; Fallopian Tubes; Female; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Nickel; Nifedipine; Nitroarginine; Norepinephrine; Peptides, Cyclic; Potassium; Receptors, Endothelin; Ryanodine; Viper Venoms

1997
Modification of radiation-induced gastrointestinal and hematopoietic injury in mice by combinations of agents: effects of indomethacin and caffeine.
    Advances in experimental medicine and biology, 1997, Volume: 400B

    Topics: Amifostine; Animals; Caffeine; Cobalt Radioisotopes; Digestive System; Drug Interactions; Gamma Rays; Hematopoiesis; Indomethacin; Interleukin-1; Male; Mice; Mice, Inbred Strains; Radiation-Protective Agents; Survival Rate

1997
Effects of cell-permeant calcium chelators on contractility in monkey basilar artery.
    Journal of neurotrauma, 1999, Volume: 16, Issue:1

    Topics: Animals; Basilar Artery; Caffeine; Calcium; Chelating Agents; Dinoprost; Dogs; Egtazic Acid; Endothelium; In Vitro Techniques; Indomethacin; Macaca fascicularis; Muscle Contraction; Muscle, Smooth, Vascular; Oxyhemoglobins; Potassium Chloride; Vasoconstriction

1999
Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01).
    Journal of periodontology, 1999, Volume: 70, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Osteoblasts; Periodontitis; Phosphodiesterase Inhibitors; Rats; Risk Factors; Time Factors

1999
Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caffeine; Cell Division; Cell Line; Cyclooxygenase Inhibitors; Drug Interactions; Flow Cytometry; Indomethacin; Kidney Tubules, Collecting; Mice; Microscopy, Electron; Salicylic Acid

2001
Characterization of adenosine action in isolated rat renal artery. Possible role of adenosine A(2A) receptors.
    General pharmacology, 2000, Volume: 35, Issue:1

    Topics: Adenosine; Animals; Caffeine; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Isotonic Solutions; Male; Models, Animal; Muscle Relaxation; Nitroarginine; Potassium Chloride; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery; Tetraethylammonium; Vasodilator Agents; Xanthines

2000
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug Combinations; Hyperalgesia; Indomethacin; Male; Mice; Migraine Disorders; Morphine; Prochlorperazine; Substance Withdrawal Syndrome; Time Factors

2002
Inhibition of prostaglandin biosynthesis in human endotoxin-stimulated peripheral blood monocytes: effects of caffeine.
    Pharmacology, 2003, Volume: 67, Issue:2

    Topics: Caffeine; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin-Endoperoxide Synthases; Statistics, Nonparametric

2003
Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:10

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Caffeine; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Motility; Indomethacin; Male; Mice; Paullinia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Stomach Ulcer

2003
Functional study of the [Ca2+]i signaling pathway in aortas of L-NAME-hypertensive rats.
    Pharmacology, 2004, Volume: 70, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Caffeine; Calcium; Calcium Signaling; Disease Models, Animal; Drug Synergism; Endothelium, Vascular; Hypertension; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenylephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Time Factors; Tunica Intima; Vasoconstriction

2004
Studies on the mechanism of caffeine action in alveolar macrophages: caffeine elevates cyclic adenosine monophosphate level and prostaglandin synthesis.
    Metabolism: clinical and experimental, 2004, Volume: 53, Issue:6

    Topics: Animals; Caffeine; Cell Survival; Cyclic AMP; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomethacin; Macrophages, Alveolar; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Sprague-Dawley; Superoxides

2004
Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine.
    The journal of pain, 2004, Volume: 5, Issue:8

    Topics: Animals; Caffeine; Disease Models, Animal; Drug Therapy, Combination; Indomethacin; Male; Mice; Migraine Disorders; Pain Measurement; Peripheral Nerves; Prochlorperazine; Sumatriptan; Trigeminal Nerve

2004
Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca(2+)-influx and Ca(2+)-release.
    Archives of pharmacal research, 2005, Volume: 28, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Caffeine; Calcium; Calcium Chloride; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Ion Transport; Membrane Potentials; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilation

2005
Effect of overuse of the antimigraine combination of indomethacin, prochlorperazine and caffeine (IPC) on the disposition of its components in chronic headache patients.
    Pharmacological research, 2006, Volume: 54, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Area Under Curve; Caffeine; Central Nervous System Stimulants; Chronic Disease; Drug Combinations; Female; Half-Life; Headache Disorders; Headache Disorders, Secondary; Humans; Indomethacin; Middle Aged; Prochlorperazine; Time Factors

2006
The effects of caffeine on the preterm sheep ductus arteriosus.
    Pediatric research, 2007, Volume: 62, Issue:2

    Topics: Animals; Caffeine; Cardiovascular Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arteriosus; Ductus Arteriosus, Patent; Female; Gestational Age; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Pregnancy; Prostaglandins; Sheep; Vasoconstriction

2007
Modulation of butyrate transport in Caco-2 cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:4

    Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetaldehyde; Acids, Acyclic; Aspirin; Biological Transport, Active; Butyrates; Caco-2 Cells; Caffeine; Cell Survival; Dronabinol; Gene Expression; Humans; Hydrogen-Ion Concentration; Indomethacin; Ions; Kinetics; Monocarboxylic Acid Transporters; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Azide; Symporters; Theophylline

2009
Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.
    Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:1

    Topics: Acetylcholine; Acorus; Animals; Aorta, Thoracic; Atropine; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Indomethacin; Inhibitory Concentration 50; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Phenylephrine; Plant Extracts; Plant Roots; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reference Standards; Ryanodine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil

2009
The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model.
    The journal of headache and pain, 2009, Volume: 10, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Caffeine; Central Nervous System Stimulants; Cerebral Arteries; Disease Models, Animal; Dopamine Antagonists; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; GTP-Binding Protein alpha Subunits, Gi-Go; Indomethacin; Male; Mice; Migraine Disorders; Prochlorperazine; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome

2009
Neuroleptics and migraine.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:1

    Topics: Antipsychotic Agents; Benzodiazepines; Brain; Caffeine; Dibenzothiazepines; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Female; Humans; Hyperprolactinemia; Indomethacin; Male; Migraine Disorders; Neural Pathways; Olanzapine; Prochlorperazine; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Treatment Outcome

2009
Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity.
    British journal of pharmacology, 2010, Volume: 160, Issue:3

    Topics: Animals; Aorta, Thoracic; Arachidonic Acids; Caffeine; Capsaicin; Chloride Channels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Vasodilation

2010
The contribution of Raman spectroscopy to the analysis of phase transformations in pharmaceutical compounds.
    International journal of pharmaceutics, 2011, Sep-30, Volume: 417, Issue:1-2

    Topics: Caffeine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Indomethacin; Pharmaceutical Preparations; Phase Transition; Povidone; Spectrum Analysis, Raman

2011
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
    Electrophoresis, 2012, Volume: 33, Issue:2

    Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution

2012
Detection of cocrystal formation based on binary phase diagrams using thermal analysis.
    Pharmaceutical research, 2013, Volume: 30, Issue:1

    Topics: Caffeine; Calorimetry, Differential Scanning; Camphor; Carbamazepine; Crystallization; Heating; Indomethacin; Niacinamide; Pharmaceutical Preparations; Phase Transition; Piroxicam; Powder Diffraction; Salicylic Acid; Theophylline; X-Ray Diffraction

2013
Development of qualitative and quantitative analysis methods in pharmaceutical application with new selective signal excitation methods for 13 C solid-state nuclear magnetic resonance using 1 H T1rho relaxation time.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:1

    Topics: Acetaminophen; Antipyrine; beta-Cyclodextrins; Caffeine; Carbon Isotopes; Chemistry, Pharmaceutical; Crystallization; Drug Combinations; Excipients; Indomethacin; Lactose; Magnetic Resonance Spectroscopy; Nifedipine; Pharmaceutical Preparations; Phenacetin; Povidone; Protons; Pyridones; Signal Processing, Computer-Assisted; Technology, Pharmaceutical

2013
Effects of chronic administration of ethanolic extract of kolanut (Cola nitida) and caffeine on vascular function.
    African journal of medicine and medical sciences, 2014, Volume: 43, Issue:1

    Topics: Acetylcholine; Animals; Aorta; Atropine; Blood Pressure; Caffeine; Cola; Dose-Response Relationship, Drug; Ethanol; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Plant Extracts; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Weight Gain

2014
Multiple perianal ulcers due to suppositories.
    The Australasian journal of dermatology, 2019, Volume: 60, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anus Diseases; Caffeine; Central Nervous System Stimulants; Chronic Disease; Dopamine Antagonists; Drug Combinations; Female; Humans; Indomethacin; Prochlorperazine; Skin Ulcer; Suppositories

2019