caffeine has been researched along with digoxin in 33 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (15.15) | 18.7374 |
1990's | 1 (3.03) | 18.2507 |
2000's | 12 (36.36) | 29.6817 |
2010's | 13 (39.39) | 24.3611 |
2020's | 2 (6.06) | 2.80 |
Authors | Studies |
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Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
Avdeef, A; Tam, KY | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Ueno, A | 1 |
Cohn, VH; Sieber, SM; Wynn, WT | 1 |
Bellet, S; Scriabine, A | 1 |
Carbonin, P; Di Gennaro, M; Pahor, M; Valle, R | 1 |
Tsanaclis, LM; Wilson, JF | 1 |
Hamilton, BP; Hamlyn, JM; Kimura, K; Manunta, P | 1 |
Bielaczyc, G; Brus, R; Durczok, K; Gabrys, J; Głowacka, M; Konecki, J; Nowak, P; Shani, J | 1 |
Arold, G; Bauer, S; Diefenbach, K; Donath, F; Friede, M; Henneicke-von Zepelin, HH; Maurer, A; Roots, I | 1 |
Cederberg, J; Dahl, ML; Karlsson, MO; Magnusson, MO; Sandström, R | 1 |
Bock, U; Haltner-Ukomadu, E; Harms, M; Hoffmann, C; Kaca, M; Lehr, CM; Müller-Goymann, C; Netzlaff, F; Schäfer, U; Tawfik Jalal, M | 1 |
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM | 1 |
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD | 1 |
Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A | 1 |
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH | 1 |
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW | 1 |
1 review(s) available for caffeine and digoxin
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 trial(s) available for caffeine and digoxin
Article | Year |
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No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Caffeine; Cardiotonic Agents; Central Nervous System Stimulants; Digoxin; Double-Blind Method; Drug Interactions; Female; Humans; Hypericum; Hypoglycemic Agents; Male; Middle Aged; Phytotherapy; Plant Extracts; Tolbutamide; Treatment Outcome | 2005 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions.
Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult | 2014 |
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.
Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide | 2022 |
28 other study(ies) available for caffeine and digoxin
Article | Year |
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Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Supraventricular tachycardia. I.
Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Atrial Flutter; Bronchitis; Bronchodilator Agents; Caffeine; Digoxin; Electrocardiography; Humans; Male; Middle Aged; Nicotine; Sympatholytics; Tachycardia; Vagus Nerve | 1971 |
Adrenolytic property of NEM in the guinea pig atria in vitro.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Digoxin; Epinephrine; Ethylmaleimide; Female; Guinea Pigs; Heart Atria; Histamine H1 Antagonists; In Vitro Techniques; Iodoacetates; Male; Muscle Contraction; Sympatholytics | 1971 |
The entry of foreign compounds into the thoracic duct lymph of the rat.
Topics: Acids; Alcohols; Amines; Aniline Compounds; Animals; Anthracenes; Antipyrine; Benzoates; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Chromatography, Thin Layer; Chylomicrons; DDT; Digoxin; Estradiol; Isoniazid; Lymph; Male; Phenanthrenes; Salicylates; Testosterone; Thoracic Duct; Time Factors; Tritium | 1974 |
Effect of caffeine on the lethal dose of digoxin in dogs.
Topics: Animals; Caffeine; Digitalis; Digoxin; Dogs; Plants, Medicinal; Plants, Toxic | 1967 |
Abolition of digitalis tachyarrhythmias by caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Digoxin; Drug Antagonism; Guinea Pigs; Heart; Heart Rate; Kinetics; Medigoxin; Sarcoplasmic Reticulum | 1983 |
Comparison by external quality assessment of performance of analytical systems for measurement of therapeutic drugs in serum.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography; Digoxin; Drug Monitoring; Immunoenzyme Techniques; Laboratories; Quality Control; Radioimmunoassay; Surveys and Questionnaires; Theophylline | 1997 |
Different effects of in vivo ouabain and digoxin on renal artery function and blood pressure in the rat.
Topics: Acetylcholine; Animals; Blood Pressure; Caffeine; Cardenolides; Cardiotonic Agents; Digoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension, Renal; In Vitro Techniques; Male; Ouabain; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Saponins; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilator Agents | 2000 |
Proteinous amino acids in hearts' muscle cytosol of rats pretreated with digoxin, caffeine or isoproterenol.
Topics: Amino Acids; Animals; Caffeine; Cytosol; Digoxin; Heart; Heart Atria; Heart Ventricles; Isoproterenol; Male; Myocardium; Rats; Rats, Wistar | 2004 |
Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Carbamazepine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Digoxin; Enzyme Induction; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Substrate Specificity | 2008 |
The physicochemical parameters of marker compounds and vehicles for use in in vitro percutaneous absorption studies.
Topics: Animal Testing Alternatives; Animals; Benzoic Acid; Buffers; Caffeine; Clotrimazole; Culture Media; Digoxin; Epidermis; Flufenamic Acid; Germany; Humans; Micelles; Polyethylene Glycols; Skin Absorption | 2008 |
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin | 2017 |
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary | 2023 |