caffeine and digoxin

caffeine has been researched along with digoxin in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (15.15)	18.7374
1990's	1 (3.03)	18.2507
2000's	12 (36.36)	29.6817
2010's	13 (39.39)	24.3611
2020's	2 (6.06)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ueno, A	1
Cohn, VH; Sieber, SM; Wynn, WT	1
Bellet, S; Scriabine, A	1
Carbonin, P; Di Gennaro, M; Pahor, M; Valle, R	1
Tsanaclis, LM; Wilson, JF	1
Hamilton, BP; Hamlyn, JM; Kimura, K; Manunta, P	1
Bielaczyc, G; Brus, R; Durczok, K; Gabrys, J; Głowacka, M; Konecki, J; Nowak, P; Shani, J	1
Arold, G; Bauer, S; Diefenbach, K; Donath, F; Friede, M; Henneicke-von Zepelin, HH; Maurer, A; Roots, I	1
Cederberg, J; Dahl, ML; Karlsson, MO; Magnusson, MO; Sandström, R	1
Bock, U; Haltner-Ukomadu, E; Harms, M; Hoffmann, C; Kaca, M; Lehr, CM; Müller-Goymann, C; Netzlaff, F; Schäfer, U; Tawfik Jalal, M	1
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM	1
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD	1
Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A	1
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH	1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW	1

Reviews

1 review(s) available for caffeine and digoxin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for caffeine and digoxin

Article	Year
No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract. Planta medica, 2005, Volume: 71, Issue:4 Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Caffeine; Cardiotonic Agents; Central Nervous System Stimulants; Digoxin; Double-Blind Method; Drug Interactions; Female; Humans; Hypericum; Hypoglycemic Agents; Male; Middle Aged; Phytotherapy; Plant Extracts; Tolbutamide; Treatment Outcome	2005
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects. Journal of clinical pharmacology, 2014, Volume: 54, Issue:4 Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult	2014
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European journal of clinical pharmacology, 2014, Volume: 70, Issue:9 Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult	2014
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers. Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:7 Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide	2022

Other Studies

28 other study(ies) available for caffeine and digoxin

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Supraventricular tachycardia. I. British medical journal, 1971, Nov-06, Volume: 4, Issue:5783 Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Atrial Flutter; Bronchitis; Bronchodilator Agents; Caffeine; Digoxin; Electrocardiography; Humans; Male; Middle Aged; Nicotine; Sympatholytics; Tachycardia; Vagus Nerve	1971
Adrenolytic property of NEM in the guinea pig atria in vitro. Japanese journal of pharmacology, 1971, Volume: 21, Issue:6 Topics: Acetylcholine; Animals; Caffeine; Calcium; Digoxin; Epinephrine; Ethylmaleimide; Female; Guinea Pigs; Heart Atria; Histamine H1 Antagonists; In Vitro Techniques; Iodoacetates; Male; Muscle Contraction; Sympatholytics	1971
The entry of foreign compounds into the thoracic duct lymph of the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1974, Volume: 4, Issue:5 Topics: Acids; Alcohols; Amines; Aniline Compounds; Animals; Anthracenes; Antipyrine; Benzoates; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Chromatography, Thin Layer; Chylomicrons; DDT; Digoxin; Estradiol; Isoniazid; Lymph; Male; Phenanthrenes; Salicylates; Testosterone; Thoracic Duct; Time Factors; Tritium	1974
Effect of caffeine on the lethal dose of digoxin in dogs. Toxicology and applied pharmacology, 1967, Volume: 11, Issue:1 Topics: Animals; Caffeine; Digitalis; Digoxin; Dogs; Plants, Medicinal; Plants, Toxic	1967
Abolition of digitalis tachyarrhythmias by caffeine. The American journal of physiology, 1983, Volume: 244, Issue:2 Topics: Animals; Blood Pressure; Caffeine; Calcium; Digoxin; Drug Antagonism; Guinea Pigs; Heart; Heart Rate; Kinetics; Medigoxin; Sarcoplasmic Reticulum	1983
Comparison by external quality assessment of performance of analytical systems for measurement of therapeutic drugs in serum. Therapeutic drug monitoring, 1997, Volume: 19, Issue:4 Topics: Anti-Arrhythmia Agents; Anticonvulsants; Bronchodilator Agents; Caffeine; Central Nervous System Stimulants; Chromatography; Digoxin; Drug Monitoring; Immunoenzyme Techniques; Laboratories; Quality Control; Radioimmunoassay; Surveys and Questionnaires; Theophylline	1997
Different effects of in vivo ouabain and digoxin on renal artery function and blood pressure in the rat. Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23 Suppl Topics: Acetylcholine; Animals; Blood Pressure; Caffeine; Cardenolides; Cardiotonic Agents; Digoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension, Renal; In Vitro Techniques; Male; Ouabain; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Saponins; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilator Agents	2000
Proteinous amino acids in hearts' muscle cytosol of rats pretreated with digoxin, caffeine or isoproterenol. Receptors & channels, 2004, Volume: 10, Issue:2 Topics: Amino Acids; Animals; Caffeine; Cytosol; Digoxin; Heart; Heart Atria; Heart Ventricles; Isoproterenol; Male; Myocardium; Rats; Rats, Wistar	2004
Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Carbamazepine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Digoxin; Enzyme Induction; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Substrate Specificity	2008
The physicochemical parameters of marker compounds and vehicles for use in in vitro percutaneous absorption studies. Alternatives to laboratory animals : ATLA, 2008, Volume: 36, Issue:2 Topics: Animal Testing Alternatives; Animals; Benzoic Acid; Buffers; Caffeine; Clotrimazole; Culture Media; Digoxin; Epidermis; Flufenamic Acid; Germany; Humans; Micelles; Polyethylene Glycols; Skin Absorption	2008
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects. Advances in therapy, 2017, Volume: 34, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin	2017
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary	2023

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