caffeine and diazepam
caffeine has been researched along with diazepam in 194 studies
Research
Studies (194)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 82 (42.27) | 18.7374 |
| 1990's | 29 (14.95) | 18.2507 |
| 2000's | 31 (15.98) | 29.6817 |
| 2010's | 47 (24.23) | 24.3611 |
| 2020's | 5 (2.58) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Butler, DE; Marriott, JG; Poschel, BP | 1 |
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Bas, D; Bruneau, P; Chipot, C; Dorison-Duval, D; Moreau, S | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Kuribara, H; Maruyama, Y; Weintraub, ST; Yoshihama, T | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Handzlik, J; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Latacz, G; Lubelska, A; Partyka, A; Wesołowska, A | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| Gong, Q; Li, J; Li, X; Liu, W; Mao, F; Qiu, X; Wang, H; Wang, W; Xu, Y; Zhang, H; Zhang, J; Zhu, J | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD | 1 |
| Angersbach, P; Babej, E; Bollmann, H; Glaser, A; Kolbe, M; Pieschl, D; Schulze, H; von Seck, P | 1 |
| Heinze, HJ; Künkel, H | 1 |
| Gourevitch, A; Yanev, S | 1 |
| Feller, K; Graupner, K; Kálmán, E; von Littrow, C | 1 |
| Day, MA; Neims, AH; Piercy, WN; Williams, RL | 1 |
| Kuribara, H; Ogawa, H; Okuizumi, K; Takokoro, S | 1 |
| Borisenko, SA; Burov, IuV | 1 |
| Butler, CM; Hill, RM; Horning, MG; Lertratanangkoon, K; Nowlin, J; Sommer, K | 1 |
| Gill, R; Osselton, MD; Smith, RM; Westlake, JP | 1 |
| Inano, S | 1 |
| Henry, G; King, DJ | 1 |
| Kuribara, H; Tadokoro, S | 1 |
| Asahi, T; Kuribara, H; Tadokoro, S | 1 |
| Bhavsar, VH; Jha, RJ; Joshi, NJ; Kelkar, VV | 1 |
| Carey, GJ; Costall, B; Domeney, AM; Jones, DN; Naylor, RJ | 1 |
| Burkhart-Kasch, S; Crabbe, JC; Gwiazdon, CC; Phillips, TJ | 1 |
| Goodwin, FK | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Dudkin, AO | 1 |
| Haraguchi, H; Kuribara, H | 1 |
| Golda, V; Petr, R | 1 |
| Furusawa, K; Tadokoro, S | 1 |
| Holtzman, SG | 1 |
| Daly, JW; Deckert, J; Jacobson, KA; Marangos, PJ; Morgan, PF | 1 |
| Haraguchi, H; Kuribara, H; Tadokoro, S | 1 |
| Hommer, DW; Skirboll, LR; Stoner, GR; Werkman, S | 1 |
| Demura, N; Goto, M; Komine, I; Sakaguchi, T; Sakurai, M | 1 |
| Bertolissi, M; de Angelis, L; Della Loggia, R; Nardini, G; Traversa, U; Vertua, R | 1 |
| Anderer, P; Grünberger, J; Kinsperger, K; Saletu, B | 1 |
| Popoli, P; Sagratella, S; Scotti de Carolis, A | 1 |
| Spealman, RD | 1 |
| Phillis, JW; Wu, PH | 2 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Mattila, M; Mattila, MJ; Seppala, T | 1 |
| Chiang, CK; Ghoneim, MM; Hinrichs, JV; Loke, WH | 1 |
| Griffiths, RR; Roache, JD | 1 |
| Boyet, S; Daval, JL; Nehlig, A; Pereira de Vasconcelos, A | 1 |
| Daval, JL; Vert, P | 1 |
| Dickmann, K; Heinze, HJ; Künkel, H; Münte, TF | 1 |
| Ghoneim, MM; Hinrichs, JV; Loke, WH | 1 |
| Forney, RB | 1 |
| Bishun, NP; Lloyd, N; Mills, J; Parke, DV; Raven, RW; Williams, DC | 1 |
| Boissier, JR; Larousse, C; Simon, P; Villeneuve, A | 1 |
| Brodie, BB; Koppanyi, T; Maling, HM; Saul, W | 1 |
| Frank, GB; Jhamandas, K | 1 |
| Ditzler, W; Plotnikoff, N; Will, F | 1 |
| Beer, B; Chasin, M; Clody, DE; Vogel, JR | 1 |
| Izquierdo, I | 1 |
| Rohmert, W; Sälzer, M | 1 |
| Sugano, H; Tominaga, H | 1 |
| Chan, G; Schiff, D; Stern, L | 2 |
| Miyata, S; Nonoyama, T; Yamamura, H; Yanagida, H | 1 |
| Inanaga, K; Ishikawa, K; Yamamoto, Y | 1 |
| Binns, PM; Ericsson, AD; Meyer, JS; Vulpe, M | 1 |
| Senault, B | 1 |
| Dítĕ, P; Krízala, JF; Krupar, V; Sita, F | 1 |
| De Marchi, F; Graziani, G | 1 |
| Kakiuchi, J | 1 |
| Paul, SM; Skolnick, P | 1 |
| Cooper, SJ | 1 |
| Medek, A | 2 |
| Ator, NA; Bigelow, GE; Brady, JV; Emurian, HH; Griffiths, RR; Hienz, RD; Lukas, SE; Nellis, MJ; Pearlson, GD; Ray, RL | 1 |
| Annau, Z; Katims, JJ; Snyder, SH | 1 |
| Annau, Z; Bruns, RF; Daly, JW; Katims, JJ; Snyder, SH | 1 |
| Boulenger, JP; Marangos, PJ; Patel, J | 1 |
| Boulenger, JP; Marangos, PJ; Parma, AM; Patel, J; Post, RM | 1 |
| Barbaz, BS; Bergen, KM; Bernard, PS; Boast, CA | 1 |
| Barberis, C; Daval, JL; Vert, P | 1 |
| Mattila, MJ; Nuotto, E | 1 |
| Vellucci, SV; Webster, RA | 1 |
| Lapin, IP | 2 |
| Heinze, HJ; Künkel, H; Münte, TF; Scholz, M | 1 |
| Moskowitz, H | 1 |
| Kelly, JD; Kratzing, CC; Oelrichs, BA | 1 |
| Edman, KA; Khan, AR | 1 |
| Fukuda, H; Goto, M; Morishita, S | 1 |
| Cassone, MC; Fundarò, A; Molinengo, L | 1 |
| Emley, GS; Hutchinson, RR | 1 |
| Coffin, VL; Wu, PH | 1 |
| Persson, LO; Sjöberg, L; Svensson, E | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Fundarò, A; Molinengo, L; Ricci Gamalero, S | 1 |
| Mattila, MJ; Palva, E; Savolainen, K | 1 |
| Chaput de Saintonge, DM; Hong, CY; Turner, P | 1 |
| Carli, M; Samanin, R | 1 |
| Angioi, RM; Bonetti, EP; Cumin, R; Haefely, WE; Möhler, H; Pieri, L; Polc, P | 1 |
| Degen, J; Maier-Lenz, H | 1 |
| Cassone, MC; Molinengo, L | 1 |
| Demas, TJ; Statland, BE | 1 |
| Desmond, PV; Dunn, GD; Hoyumpa, AM; Johnson, RF; Patwardhan, RV; Robertson, DH; Schenker, S | 1 |
| Golda, V | 1 |
| Kuribara, H | 1 |
| Hughes, RN | 1 |
| Fisher, CE; Hughes, RN | 1 |
| Bradbury, A; Houston, JB; Worboys, PD | 2 |
| Liu, F; Liu, L; Lu, YQ; Luo, Y; Qiu, FH | 1 |
| Khalil, RH; Soliman, MR | 1 |
| Kuribara, H; Maruyama, Y; Stavinoha, WB | 1 |
| Mizojiri, K; Tanaka, H | 1 |
| Campos, AR; Paula, WG; Rao, VS; Santos, FA; Silva, RM | 1 |
| Song, HR; Wu, CF; Yang, JY | 1 |
| Ali, BH; Bashir, AK; Tanira, MO | 1 |
| Meyer, FP | 1 |
| Cheng, HL; Her, GR; Tsai, PL; Tseng, MC | 1 |
| Kim, SU; Krieger, C; Puil, E; Yokogawa, T | 1 |
| Ferreyra, CF; Ortiz, CS | 1 |
| Büyükokuroğlu, ME; Demirezer, LO; Güvenalp, Z | 1 |
| Daly, JW; Padgett, WL; Shi, D | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| Blaauboer, B; Forsby, A | 1 |
| Cecener, G; Egeli, U; Tunca, B; Yilmazlar, T; Zorluoglu, A | 1 |
| Calo, G; Guerrini, R; Marzola, G; Regoli, D; Rizzi, A; Ruzza, C; Salvadori, S; Vergura, R | 1 |
| Calò, G; Filaferro, M; Frigeri, C; Guerrini, R; Pennella, S; Rizzi, A; Ruggieri, V; Vitale, G | 1 |
| Amri, H; Bartels, B; Beeson, E; Bergner, C; Cachat, J; Canavello, P; Chung, A; Chung, KM; Duncan, A; Egan, R; Elegante, M; Elkhayat, S; Gaikwad, S; Gilder, T; Goodspeed, J; Grimes, C; Hart, P; Kadri, F; Kalueff, AV; Mohnot, S; Rosenberg, M; Roy, S; Soignier, RD; Stewart, A; Suciu, C; Tan, J; Tien, D; Wong, K; Zapolsky, I; Zukowska, Z | 1 |
| Bradley, BF; Bridges, NJ; Brown, SL; Lea, RW; Starkey, NJ | 1 |
| Braun, AA; Skelton, MR; Vorhees, CV; Williams, MT | 1 |
| Shen, XD; Wei, EQ; Ye, YL; Zhang, JT; Zhang, Q; Zhang, WP; Zhong, YW | 1 |
| Colwill, RM; Creton, R; Pelkowski, SD; Richendrfer, H | 1 |
| Amaral, VC; Campos, KF; Miguel, TT; Nunes-de-Souza, RL; Rico, JL | 1 |
| Araújo, J; Benzecry, R; da Silva, AW; Gouveia, A; Herculano, AM; Lima, MG; Maximino, C; Miranda, V; Oliveira, KR; Picanço-Diniz, DL; Puty, B | 1 |
| Dinsdale, A; Gibson, JL; Nesbitt, I; Walker, H | 1 |
| Chow, H; Desai, P; Facciol, A; Fulcher, N; Gerlai, R; Nowicki, M; Tran, S; Tsang, B | 1 |
| Al-Jubouri, Q; Al-Nuaimy, W; Lopez-Luna, J; Sneddon, LU | 1 |
| Coboeken, K; Dallmann, A; Eissing, T; Hempel, G; Ince, I | 1 |
| Hansen, SE; Jacobsen, J; Janfelt, C; Marxen, E | 1 |
| Borba, JV; Canzian, J; Costa, FV; Quadros, VA; Rosa, LV; Rosemberg, DB | 1 |
| Boy, D; Büttner, A; Kegler, R; Kolbe, V; Rentsch, D; Schmidt, B | 1 |
| Fontana, BD; Parker, MO | 1 |
| Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR | 1 |
Reviews
6 review(s) available for caffeine and diazepam
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Chromosome damage induced by chemicals.
Topics: Antineoplastic Agents; Aspirin; Benzene; Caffeine; Chloramphenicol; Chlorine; Chlorpromazine; Chromosome Aberrations; Chromosomes; Colchicine; Contraceptives, Oral; Cyclamates; Diazepam; Dibenzazepines; Drug Evaluation; Ethanol; Humans; Hydroxylamines; Lithium; Lymphocyte Culture Test, Mixed; Lysergic Acid Diethylamide; Nicotine; Organophosphorus Compounds; Ozone; Pesticides; Phenylbutazone | 1973 |
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; Cats; Cattle; Diazepam; gamma-Aminobutyric Acid; Humans; Molecular Weight; Muscle Relaxation; Neurotransmitter Agents; Niacinamide; Purines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures; Sleep Wake Disorders | 1981 |
Adenosine receptor interactions and anxiolytics.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Diazepam; Humans; Motor Activity; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic | 1983 |
The neuropharmacology of various diazepam antagonists.
Topics: Animals; Benzodiazepinones; Caffeine; Carbolines; Diazepam; Flumazenil; Humans; Physostigmine; Pyrazoles; Receptors, Cell Surface; Receptors, GABA-A; Theophylline | 1983 |
Psycho- and immunopharmacological factors relevant to selection of volunteers in clinical studies.
Topics: Adult; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Clinical Trials as Topic; Diazepam; Healthy Volunteers; Humans; Kinetics; Mental Health; Patient Selection; Personality; Psychotropic Drugs | 2001 |
Trials
13 trial(s) available for caffeine and diazepam
| Article | Year |
|---|---|
[Combined study of Silentan. Test of a headache remedy in general and clinical practice].
Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Diazepam; Dihydroergotamine; Double-Blind Method; Drug Combinations; Female; Headache; Humans; Male; Middle Aged | 1979 |
The effect of neuroleptics on cognitive and psychomotor function. A preliminary study in healthy volunteers.
Topics: Adult; Antipsychotic Agents; Arousal; Attention; Caffeine; Diazepam; Female; Flicker Fusion; Haloperidol; Humans; Life Change Events; Male; Neuropsychological Tests; Personality Inventory; Problem Solving; Psychomotor Performance; Reaction Time; Sensory Thresholds; Trihexyphenidyl | 1992 |
Attrition of the Zeigarnik effect: role of subjects' expectancy aroused by placebos.
Topics: Caffeine; Diazepam; Double-Blind Method; Humans; Mental Recall; Placebo Effect; Placebos | 1992 |
Topographic brain mapping of EEG in neuropsychopharmacology--Part II. Clinical applications (pharmaco EEG imaging).
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Brain; Brain Mapping; Bromazepam; Caffeine; Central Nervous System Stimulants; Chlorprothixene; Diazepam; Electroencephalography; Female; GABA Antagonists; Humans; Male | 1987 |
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam.
Topics: Adult; Anxiety; Arousal; Caffeine; Clonidine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Female; Growth Hormone; Humans; Hydrocortisone; Male; Panic; Prolactin; Yohimbine | 1988 |
Pharmacokinetic and pharmacodynamic interactions between caffeine and diazepam.
Topics: Adolescent; Adult; Caffeine; Clinical Trials as Topic; Cognition; Diazepam; Double-Blind Method; Drug Interactions; Drug Tolerance; Emotions; Female; Humans; Kinetics; Learning; Male; Memory; Psychological Tests; Random Allocation | 1986 |
Caffeine and diazepam: separate and combined effects on mood, memory, and psychomotor performance.
Topics: Adolescent; Adult; Affect; Caffeine; Diazepam; Discrimination, Psychological; Drug Interactions; Female; Humans; Learning; Male; Memory; Mental Processes; Psychomotor Performance; Retention, Psychology | 1985 |
International seminar research on alcohol, drugs and driving.
Topics: Alcohol Drinking; Auditory Perception; Automobile Driving; Caffeine; Chlordiazepoxide; Clinical Trials as Topic; Color Perception Tests; Dextroamphetamine; Diazepam; Diphenhydramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Ethanol; Feedback; Glutethimide; Histamine H1 Antagonists; Humans; Meprobamate; Motor Skills; Nortriptyline; Placebos; Postural Balance; Secobarbital; Tripelennamine | 1973 |
[Investigation on the time series of the hand-tremor amplitude under the influence of different pharmacas (author's transl)].
Topics: Adult; Body Height; Body Weight; Caffeine; Diazepam; Ethanol; Glucose; Hand; Humans; Nicotine; Placebos; Rest; Smoking; Time Factors; Tremor | 1974 |
Effect of loading and labyrinthine stimulation on body movement.
Topics: Adult; Body Weight; Caffeine; Clinical Trials as Topic; Diazepam; Ear, Inner; Electric Stimulation; Ethanol; Fatigue; Female; Functional Laterality; Humans; Male; Motion Sickness; Movement; Parasympatholytics; Postural Balance; Pyridinium Compounds; Reflex | 1973 |
Caffeine and theophylline counteract diazepam effects in man.
Topics: Adult; Caffeine; Clinical Trials as Topic; Cognition; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Antagonism; Female; Flicker Fusion; Humans; Male; Psychomotor Performance; Theophylline | 1983 |
Personality traits influence the effects of diazepam and caffeine on CNV magnitude.
Topics: Adult; Affect; Arousal; Attention; Caffeine; Contingent Negative Variation; Diazepam; Electrophysiology; Humans; Male; Models, Neurological; Personality; Reaction Time | 1984 |
Mood effects of diazepam and caffeine.
Topics: Adult; Caffeine; Diazepam; Discrimination, Psychological; Emotions; Extraversion, Psychological; Female; Heart Rate; Humans; Male; Sex Factors; Substance-Related Disorders; Time Factors | 1980 |
Other Studies
175 other study(ies) available for caffeine and diazepam
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Cognition-activating properties of 3-(Aryloxy)pyridines.
Topics: Animals; Cognition; Dose-Response Relationship, Drug; Male; Mice; Psychotropic Drugs; Pyridines; Structure-Activity Relationship | 1981 |
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogPoct: a tool for lipophilicity determination in drug discovery.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Rational determination of transfer free energies of small drugs across the water-oil interface.
Topics: Alkanes; Antipyrine; Caffeine; Computer Simulation; Ganciclovir; Glucose; Pharmaceutical Preparations; Solubility; Water | 2002 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Caffeine; Cyclopentanes; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity; Phenobarbital; Plant Extracts; Plants, Medicinal; Sleep | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 2018 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT
Topics: Dose-Response Relationship, Drug; Humans; Hydantoins; Molecular Structure; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Depression; Drug Design; Ligands; Mice; Permeability; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Tacrine; Vilazodone Hydrochloride | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice | 2020 |
The significance of personality traits in EEG evaluation of drug effects.
Topics: Amitriptyline; Caffeine; Diazepam; Electroencephalography; Humans; Personality; Pyrithioxin | 1979 |
Motor estimation of short time intervals under the effect of some psychotropic drugs.
Topics: Adult; Amphetamine; Caffeine; Chlorpromazine; Diazepam; Humans; Phenobarbital; Psychotropic Drugs; Reaction Time; Task Performance and Analysis; Time Perception | 1979 |
[The influence of centrally acting drugs on flicker fusion frequency].
Topics: Caffeine; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Flicker Fusion; Humans; Meprobamate; Psychotropic Drugs | 1975 |
Alteration of ovine fetal respiratory-like activity by diazepam, caffeine, and doxapram.
Topics: Animals; Blood Gas Analysis; Caffeine; Depression, Chemical; Diazepam; Doxapram; Female; Fetal Blood; Fetus; Infusions, Parenteral; Pregnancy; Pressure; Respiration; Sheep; Stimulation, Chemical; Trachea | 1977 |
Interactions of alcohol with drugs.
Topics: Amphetamines; Caffeine; Chlorpromazine; Diazepam; Disulfiram; Drug Interactions; Ethanol; Humans | 1977 |
Attainment and stability of the performance in differential low rate water reinforcement in rats.
Topics: Animals; Behavior, Animal; Body Weight; Caffeine; Conditioning, Operant; Diazepam; Male; Methamphetamine; Pentobarbital; Rats; Reinforcement Schedule; Time Factors; Water; Water Deprivation | 1976 |
[The effect of psychotropic substances on the mental and physical work capacity of rats].
Topics: Amphetamine; Animals; Benactyzine; Caffeine; Chlordiazepoxide; Cocaine; Diazepam; Disability Evaluation; Electric Stimulation; Learning; Male; Meprobamate; Morphine; Phenobarbital; Psychotropic Drugs; Rats; Reinforcement, Psychology; Self Stimulation; Stimulation, Chemical; Work Capacity Evaluation | 1975 |
Clinical applications of gas chromatograph/mass spectrometer/computer systems.
Topics: Autoanalysis; Caffeine; Chromatography, Gas; Computers; Diazepam; Evaluation Studies as Topic; Female; Humans; Imides; Indicators and Reagents; Mass Spectrometry; Methods; Milk, Human; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Pregnancy; Theobromine; Time Factors | 1975 |
Retention reproducibility of basic drugs in high-performance liquid chromatography on a silica column with a methanol-high-pH buffer eluent. Changes in selectivity with the age of the stationary phase.
Topics: Caffeine; Chromatography, High Pressure Liquid; Diazepam; Hydrogen-Ion Concentration; Methanol; Nitrazepam; Reproducibility of Results; Silicon Dioxide | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic; Seizures | 1992 |
Caffeine does not effectively ameliorate, but rather may worsen the ethanol intoxication when assessed by discrete avoidance in mice.
Topics: Alcoholic Intoxication; Animals; Caffeine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Male; Mice; Mice, Inbred Strains; Pentobarbital | 1992 |
Ethanol enhances, but diazepam and pentobarbital reduce the ambulation-increasing effect of caffeine in mice.
Topics: Animals; Caffeine; Diazepam; Drug Interactions; Drug Synergism; Ethanol; Locomotion; Male; Mice; Mice, Inbred Strains; Pentobarbital | 1992 |
Behavioural effects of anxiogenic agents in the common marmoset.
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Caffeine; Callithrix; Carbolines; Diazepam; Motor Activity; Pentylenetetrazole; Yohimbine | 1992 |
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Pentobarbital; Substance-Related Disorders | 1992 |
From the Alcohol, Drug Abuse, and Mental Health Administration.
Topics: Brain; Caffeine; Cocaine; Diazepam; Drug Synergism; Ethanol; Fetus; Humans; Memory; Memory Disorders; Substance Withdrawal Syndrome; United States; United States Substance Abuse and Mental Health Services Administration | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulation; Rabbits; Visual Cortex | 1991 |
Behavioral effects of adenosine agonists: evaluation by punishment, discrete shuttle avoidance and activity tests in mice.
Topics: Adenosine; Animals; Avoidance Learning; Caffeine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred Strains; Motor Activity; Phenylisopropyladenosine; Punishment; Reinforcement Schedule; Xanthines | 1991 |
Validation of aversion towards open space and height as a measure of anxiety in the genetically based animal model of depression.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Depressive Disorder; Diazepam; Disease Models, Animal; Female; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Tranylcypromine | 1990 |
Effects of psychoactive drugs on the conflict behavior under operant situation in Mongolian gerbils (Meriones unguiculatus).
Topics: Animals; Caffeine; Conditioning, Operant; Conflict, Psychological; Diazepam; Ethanol; Gerbillinae; Male; Morphine; Nicotine; Pentobarbital; Psychotropic Drugs | 1990 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random Allocation; Seizures; Theophylline; Xanthines | 1989 |
Anticonflict effect of caffeine: investigation by punishment and hypertonic NaCl solution procedures in mice.
Topics: Animals; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drinking; Male; Mice; Punishment; Saline Solution, Hypertonic | 1989 |
Preferential effects of caffeine on limbic and cortical dopamine systems.
Topics: Animals; Caffeine; Diazepam; Frontal Lobe; Haloperidol; Limbic System; Male; Mesencephalon; Neural Pathways; Neurons; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Synaptic Transmission | 1988 |
[Pharmacological comparison of the CNS effects of propentofylline and caffeine].
Topics: Animals; Anticonvulsants; Caffeine; Cats; Central Nervous System; Diazepam; Female; Male; Mice; Mice, Inbred ICR; Muscle Relaxation; Receptors, GABA-A; Reflex, Monosynaptic; Xanthines | 1988 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; Electroshock; Male; Mice; Nordazepam; Pentylenetetrazole; Seizures | 1985 |
An EEG and behavioural study on the excitatory properties of caffeine in rabbits.
Topics: Animals; Behavior, Animal; Brain; Caffeine; Central Nervous System Stimulants; Diazepam; Electric Stimulation; Electroencephalography; Hippocampus; Phenylisopropyladenosine; Rabbits; Stimulation, Chemical | 1987 |
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine | 1985 |
Up-regulation of brain [3H]diazepam binding sites in chronic caffeine treated rats.
Topics: Animals; Binding Sites; Brain; Caffeine; Diazepam; Kinetics; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Purinergic | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Interactions of diazepam and caffeine: behavioral and subjective dose effects in humans.
Topics: Adolescent; Adult; Affect; Behavior; Caffeine; Cognition; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Psychomotor Performance; Time Factors | 1987 |
Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Caffeine; Deoxy Sugars; Deoxyglucose; Diazepam; Energy Metabolism; Male; Rats; Rats, Inbred Strains | 1987 |
Effect of chronic exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings.
Topics: Animals; Brain; Caffeine; Diazepam; Female; Lactation; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Synaptosomes; Theophylline | 1986 |
[Methodological aspects of the analysis of the effects of drugs (diazepam and caffeine) on contingent negative variation].
Topics: Adult; Caffeine; Contingent Negative Variation; Diazepam; Electrophysiology; Humans; Methods | 1985 |
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Electroshock; Haloperidol; Humans; Imipramine; Iproniazid; Meprobamate; Monoamine Oxidase Inhibitors; Motor Activity; Parasympatholytics; Pargyline; Prenylamine; Procyclidine; Rats; Reflex; Reserpine; Seizures; Tranylcypromine | 1968 |
Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system.
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Amobarbital; Animals; Anticonvulsants; Barbiturates; Benzazepines; Blood Glucose; Body Temperature; Brain Chemistry; Caffeine; Chlordiazepoxide; Chlorisondamine; Dextroamphetamine; Diazepam; Drug Synergism; Fatty Acids, Nonesterified; Male; Mice; Motor Activity; Pempidine; Pentobarbital; Pentylenetetrazole; Phentolamine; Propranolol; Sympathetic Nervous System | 1970 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents | 1970 |
Stimulant activity of pemoline and magnesium hydroxide.
Topics: Animals; Antacids; Ataxia; Caffeine; Cats; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Coma; Diazepam; Dogs; Drug Antagonism; Haplorhini; Hydroxides; Magnesium; Methamphetamine; Methylphenidate; Mice; Motor Activity; Pemoline; Pupil; Resins, Plant; Stimulation, Chemical; Tetrabenazine; Vomiting | 1969 |
Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.
Topics: Animals; Anxiety; Barbiturates; Brain; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Cyclic AMP; Diazepam; Humans; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Punishment; Rats; Theobromine; Theophylline; Tranquilizing Agents | 1972 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
Proceedings: Clinical implications of bilirubin-albumin binding in the newborn.
Topics: Age Factors; Benzoates; Bilirubin; Caffeine; Diazepam; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Oleic Acids; Protein Binding; Serum Albumin | 1973 |
[Electroencephalographic observation of the effect of direct injection of anesthetics and other drugs into the mesencephalic reticular formation].
Topics: Analgesics; Anesthetics; Animals; Benzoates; Caffeine; Cats; Diazepam; Electroencephalography; Epinephrine; Fentanyl; Injections; Mesencephalon; Pentazocine; Procaine; Reticular Formation; Thiopental | 1971 |
Study of the averaged photopalpebral reflex in man.
Topics: Adult; Caffeine; Computers; Diazepam; Electroencephalography; Ethanol; Eyelids; Female; Humans; Light; Male; Reflex | 1971 |
Sphenopalatine gangionectomy for cluster headache.
Topics: Adult; Analgesics; Caffeine; Carbamazepine; Cortisone; Diazepam; Ergotamine; Female; Ganglia, Autonomic; Headache; Humans; Isoproterenol; Male; Methods; Methysergide; Middle Aged; Neuralgia; Palate; Phenytoin; Progesterone; Prognosis; Sphenoid Bone | 1970 |
[Intraspecific aggressive behavior induced by apomorphine in the rat].
Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine | 1970 |
Fixed drug combinations and the displacement of bilirubin from albumin.
Topics: Benzoates; Bilirubin; Caffeine; Chromatography, Gel; Diazepam; Drug Synergism; Humans; Infant, Newborn; Infant, Premature, Diseases; Kernicterus; Protein Binding; Serum Albumin; Sodium; Spectrum Analysis; Sulfisoxazole | 1971 |
[Detection of drugs in knee joint synovia].
Topics: Albumins; Aspirin; Binding Sites; Biological Transport; Caffeine; Chlorpromazine; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Diazepam; Ephedrine; Forensic Medicine; Humans; Knee Joint; Meprobamate; Methods; Molecular Weight; Morphine; Phenacetin; Phenylbutazone; Procaine; Synovial Fluid; Synovial Membrane | 1971 |
[Pharmacologic research on the dimethylaminoethanol salt of 7-chloro-1,3-dihydro-3-hemisuccinyloxy-5-phenyl-2H-1,4-benzodiazepin-2-one].
Topics: Animals; Behavior, Animal; Caffeine; Diazepam; Drug Synergism; Male; Methamphetamine; Nutritional Physiological Phenomena; Oxazepam; Pentobarbital; Rabbits; Rats; Strychnine; Tetrazolium Salts; Tremorine | 1967 |
[Influence of various drugs on the mechanism of ptokinetic after-nystagmus. 1].
Topics: Adult; Barbiturates; Caffeine; Diazepam; Electromyography; Female; Humans; Male; Nystagmus, Pathologic; Ophthalmic Nerve | 1966 |
Caffeine-induced hypodipsia in water-deprived rats: relationships with benzodiazepine mechanisms.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Diazepam; Drinking Behavior; Male; Midazolam; Rats; Satiation; Time Factors; Water Deprivation | 1982 |
Adenosine mediates sedative action of various centrally active drugs.
Topics: Adenosine; Animals; Antipsychotic Agents; Arousal; Brain; Caffeine; Diazepam; Hypnotics and Sedatives; Phenothiazines; Rats; Receptors, Cell Surface; Receptors, Purinergic; Synapses; Synaptic Transmission; Synaptosomes; Theophylline | 1982 |
Effect of some drugs, experimental stress and estrus on unstable and fixed conditioned alimentary motor reflexes in cats. Part II.
Topics: Amphetamine; Animals; Barbiturates; Caffeine; Cats; Chlorprothixene; Conditioning, Classical; Diazepam; Digestive System; Digestive System Physiological Phenomena; Estrus; Female; Male; Motor Activity; Piracetam; Pregnancy; Pyrithioxin; Stress, Physiological | 1983 |
Abuse liability and behavioral toxicity assessment: progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Caffeine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Marijuana Abuse; Nicotine; Papio; Phencyclidine; Phencyclidine Abuse; Smoking; Substance-Related Disorders | 1984 |
Interactions in the behavioral effects of methylxanthines and adenosine derivatives.
Topics: Adenosine; Animals; Blood Pressure; Brain; Caffeine; Cardiac Complexes, Premature; Diazepam; Drug Interactions; Heart Rate; Male; Mice; Mice, Inbred ICR; Motor Activity; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Stimulation, Chemical; Xanthines | 1983 |
Effect of some drugs, experimental stress and estrus on unstable and fixed conditioned alimentary motor reflexes in cats.
Topics: Amphetamine; Animals; Barbiturates; Behavior, Animal; Caffeine; Cats; Chlorprothixene; Conditioning, Classical; Diazepam; Estrus; Feeding Behavior; Female; Food Supply; Humans; Male; Motor Skills; Piracetam; Pregnancy; Psychotropic Drugs; Pyrithioxin; Stress, Psychological | 1982 |
Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain.
Topics: Adenosine; Binding, Competitive; Brain; Caffeine; Diazepam; Humans; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Purinergic; Theophylline; Xanthines | 1982 |
Chronic caffeine consumption increases the number of brain adenosine receptors.
Topics: Adenosine; Animals; Brain; Caffeine; Diazepam; Diet; Mice; Receptors, Cell Surface; Receptors, Purinergic; Xanthines | 1983 |
In vitro and in vivo displacement of [3H]-diazepam binding by purine derivatives in developing rat brain.
Topics: Animals; Binding, Competitive; Brain; Caffeine; Diazepam; Female; In Vitro Techniques; Kinetics; Male; Membranes; Pregnancy; Purines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Theophylline | 1984 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors, Drug; Seizures | 1984 |
[Interaction of kynurenine and diazepam].
Topics: Animals; Benzoates; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenine; Mice; Mice, Inbred Strains; Pentylenetetrazole; Reaction Time; Seizures | 1984 |
Attention tasks as skills performance measures of drug effects.
Topics: Accidents, Traffic; Attention; Automobile Driving; Behavior; Caffeine; Cannabis; Cognition; Diazepam; Diphenhydramine; Ethanol; Flurazepam; Humans; Perception; Psychomotor Performance; Reaction Time; Time Factors | 1984 |
Ascorbic acid changes in brain.
Topics: Animals; Ascorbic Acid; Barbital; Brain; Caffeine; Diazepam; Environment; Ethanol; Male; Rats; Thyroidectomy | 1984 |
Diazepam, a highly effective twitch potentiator in isolated muscle fibres of the frog.
Topics: Action Potentials; Animals; Caffeine; Diazepam; Electric Stimulation; Membrane Potentials; Muscle Contraction; Potassium; Rana temporaria | 1983 |
Anticonvulsant action of diazepam in mice pretreated with caffeine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Caffeine; Diazepam; Drug Interactions; Electroencephalography; Electromyography; Female; Mice; Mice, Inbred ICR; Pentylenetetrazole | 1983 |
Action of antidepressants, stimulants and depressants in the transition from a fixed ratio to a fixed interval schedule of reinforcement.
Topics: Amitriptyline; Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Operant; Diazepam; Doxepin; Imipramine; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1983 |
Unique influences of ten drugs upon post-shock biting attack and pre-shock manual responding.
Topics: Aggression; Animals; Bites and Stings; Caffeine; Chlordiazepoxide; Chlorpromazine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diazepam; Electroshock; Ethanol; Female; Humans; Male; Morphine; Nicotine; Phenobarbital; Saimiri | 1983 |
Up-regulation of brain [3H]diazepam binding sites in chronic caffeine-treated rats.
Topics: Animals; Binding Sites; Brain; Caffeine; Diazepam; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains | 1984 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Action of caffeine, d-amphetamine, diazepam and imipramine in a dynamic behavioural situation.
Topics: Animals; Behavior, Animal; Caffeine; Conditioning, Operant; Dextroamphetamine; Diazepam; Imipramine; Male; Rats; Rats, Inbred Strains; Reinforcement Schedule; Reversal Learning | 1983 |
Caffeine antagonizes diazepam effects in man.
Topics: Adult; Caffeine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flicker Fusion; Humans; Male; Mental Processes; Muscle Contraction; Muscle Relaxation; Placebos; Temperament | 1982 |
Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility.
Topics: Caffeine; Central Nervous System; Chlorpromazine; Diazepam; Humans; In Vitro Techniques; Male; Phenobarbital; Phenytoin; Sperm Motility | 1982 |
Evidence that agents increasing water consumption do not necessarily generate "false positives" in conflict procedures using water as a reinforcer.
Topics: Animals; Caffeine; Conflict, Psychological; Diazepam; Drinking Behavior; Electroshock; Female; Isoproterenol; Punishment; Rats; Reinforcement, Psychology | 1982 |
Caffeine antagonizes several central effects of diazepam.
Topics: Aggression; Animals; Caffeine; Cats; Central Nervous System; Conflict, Psychological; Diazepam; Humans; Hypothalamus; Muscle Tonus; Pentylenetetrazole; Phenobarbital; Spinal Cord | 1981 |
[Comparative pharmacokinetics and relative bioavailability of the active principles diazepam, acetylsalicylic acid, caffeine, and dihydroergotamine tartrate in a combination product].
Topics: Adult; Aspirin; Biological Availability; Caffeine; Diazepam; Dihydroergotamine; Drug Combinations; Humans; Kinetics; Male | 1982 |
Action of thyroid hormones, diazepam, caffeine and amitriptyline on memory decay ("forgetting").
Topics: Amitriptyline; Animals; Caffeine; Diazepam; Hyperthyroidism; Hypothyroidism; Male; Memory; Methimazole; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroxine | 1981 |
Serum caffeine half-lives. Healthy subjects vs. patients having alcoholic hepatic disease.
Topics: Adult; Caffeine; Diazepam; Female; Half-Life; Humans; Kinetics; Liver Diseases, Alcoholic; Male; Middle Aged | 1980 |
Effects of caffeine on plasma free fatty acids, urinary catecholamines, and drug binding.
Topics: Blood Proteins; Caffeine; Catecholamines; Chlordiazepoxide; Diazepam; Drug Interactions; Fatty Acids, Nonesterified; Female; Humans; Male; Pharmaceutical Preparations; Propranolol; Protein Binding | 1980 |
Motor depression induced by rapid repeated transposition of rat: effect of diazepam, tranylcypromine and caffeine treatment.
Topics: Animals; Caffeine; Diazepam; Exploratory Behavior; Female; Hypertension; Male; Motor Activity; Rats; Rats, Wistar; Stress, Physiological; Tranylcypromine | 1994 |
Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.
Topics: Animals; Avoidance Learning; Caffeine; Chlorpromazine; Diazepam; Electroshock; Imipramine; Male; Mice; Morphine; Nicotine; Psychotropic Drugs; Signal Detection, Psychological | 1994 |
Effects on open-field behavior of diazepam and buspirone alone and in combination with chronic caffeine.
Topics: Animals; Behavior, Animal; Buspirone; Caffeine; Diazepam; Drug Interactions; Female; Male; Rats; Rats, Wistar; Sex Factors | 1993 |
Effects of diazepam and cyclohexyladenosine on open-field behavior in rats perinatally exposed to caffeine.
Topics: Adenosine; Animals; Caffeine; Diazepam; Eliminative Behavior, Animal; Emotions; Female; Grooming; Locomotion; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Sex Characteristics | 1996 |
Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Diazepam; In Vitro Techniques; Kinetics; Liver; Male; Phenytoin; Rats; Rats, Sprague-Dawley | 1996 |
Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.
Topics: Animals; Caffeine; Diazepam; In Vitro Techniques; Liver; Male; Ondansetron; Pharmacokinetics; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide | 1997 |
[Systematic analysis of basic drugs in plasma using X-5 solid-phase extraction GC-FID and GC-MS].
Topics: Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Caffeine; Central Nervous System Stimulants; Chromatography, Gas; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Meperidine; Phenothiazines | 1996 |
Diazepam alters caffeine-induced effects on beta-endorphin levels in specific rat brain regions.
Topics: Animals; beta-Endorphin; Brain; Caffeine; Dark Adaptation; Diazepam; Drug Interactions; Male; Rats; Rats, Sprague-Dawley | 1997 |
Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Bicuculline; Biphenyl Compounds; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Injections, Subcutaneous; Lignans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Tetragastrin; Therapeutic Equivalency | 1998 |
Antagonism of kynurenic acid to anxiogens in mice.
Topics: Animals; Anxiety; Brain; Caffeine; Diazepam; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Kynurenic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Phenethylamines; Yohimbine | 1998 |
Drug-protein binding and blood-brain barrier permeability.
Topics: Animals; Benzodiazepines; Blood-Brain Barrier; Bridged Bicyclo Compounds; Caffeine; Calcium Channel Blockers; Diazepam; Dihydropyridines; Fatty Acids, Monounsaturated; Male; Microcirculation; Models, Biological; Nootropic Agents; Perfusion; Permeability; Pharmaceutical Preparations; Propranolol; Prosencephalon; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Serum Albumin, Bovine | 1999 |
Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pentoxifylline | 1999 |
Studies on the sedative and hypnotic effects of oleamide in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Hypnotics and Sedatives; Male; Methamphetamine; Mice; Motor Activity; Oleic Acids; Pentobarbital; Sleep | 1999 |
The effect of Rhazya stricta Decne, a traditional medicinal plant, on spontaneous and drug-induced alterations in activity of rats.
Topics: Animals; Anti-Anxiety Agents; Caffeine; Central Nervous System Stimulants; Diazepam; Dopamine; Drug Interactions; Male; Motor Activity; Muscle Relaxants, Central; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Time Factors; Zoxazolamine | 1999 |
Analysis of synthetic chemical drugs in adulterated Chinese medicines by capillary electrophoresis/electrospray ionization mass spectrometry.
Topics: Anti-Inflammatory Agents; Caffeine; Diazepam; Drug Contamination; Drugs, Chinese Herbal; Electrophoresis, Capillary; Micelles; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Taiwan | 2001 |
Analysis of GABA(A)- and GABA(B)-receptor mediated effects on intracellular Ca(2+) in DRG hybrid neurones.
Topics: Acrylates; Adenosine Triphosphate; Animals; Bicuculline; Caffeine; Calcium; Capsaicin; Cell Line; Diazepam; Dihydropyridines; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hybrid Cells; Mice; Mice, Inbred BALB C; Neurons; Potassium Chloride; Receptors, GABA-A; Receptors, GABA-B; Thapsigargin; Time Factors | 2001 |
Simultaneous spectrophotometric determination of phenilpropanolamine HCL, caffeine and diazepam in tablets.
Topics: Caffeine; Chromatography, High Pressure Liquid; Diazepam; Phenylpropanolamine; Spectrophotometry, Ultraviolet; Tablets | 2002 |
Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Depression; Diazepam; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Seizures; Sleep; Swimming; Thiopental; Turkey; Valerianaceae | 2002 |
Caffeine analogs: effects on ryanodine-sensitive calcium-release channels and GABAA receptors.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Caffeine; Calcium Signaling; Cell Membrane; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Muscle, Skeletal; Neurons; Rabbits; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Ryanodine; Ryanodine Receptor Calcium Release Channel; Xanthines | 2003 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.
Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous System Stimulants; Diazepam; Endpoint Determination; Humans; Hypnotics and Sedatives; Kinetics; Lethal Dose 50; Models, Statistical; Nerve Tissue Proteins; Neuroblastoma; Neurotoxicity Syndromes; Pesticides; Phenytoin; Rats; Xenobiotics | 2007 |
The mutation spectrum of the APC gene in Turkish patients with familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Aspirin; Biomarkers, Tumor; Caffeine; Diazepam; Dihydroergotamine; Drug Combinations; Gene Deletion; Genes, APC; Heteroduplex Analysis; Humans; Pedigree; Sequence Analysis, DNA; Turkey | 2007 |
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Temperature Regulation; Caffeine; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Injections, Intraventricular; Male; Mice; Motor Activity; Neuropeptides; Reflex; Sleep; Stress, Psychological; Time Factors | 2008 |
Anxiolytic-like effect of neuropeptide S in the rat defensive burying.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Humans; Male; Neuropeptides; Rats; Rats, Wistar | 2008 |
Modeling withdrawal syndrome in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Ethanol; Exploratory Behavior; Female; Hydrocortisone; Male; Morphine; Substance Withdrawal Syndrome; Time Factors; Zebrafish | 2010 |
Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Caffeine; Carbolines; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Female; GABA Antagonists; Gerbillinae; Male; Sex Factors | 2011 |
Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Female; Male; Maze Learning; Nicotine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Yohimbine | 2011 |
[Comparison of behavioral effects of psychoactive drugs between two strains of mice].
Topics: Animals; Caffeine; Central Nervous System Agents; Chloral Hydrate; Diazepam; Dose-Response Relationship, Drug; Ephedrine; Mice; Mice, Inbred ICR; Motor Activity | 2011 |
On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae.
Topics: Animals; Anxiety; Caffeine; Cues; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluoxetine; Spatial Behavior; Swimming; Zebrafish | 2012 |
Ethopharmacological evaluation of the rat exposure test: a prey-predator interaction test.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Diazepam; Escape Reaction; Factor Analysis, Statistical; Fluoxetine; Food Chain; Imipramine; Male; Mice; Motor Activity; Posture; Predatory Behavior; Rats; Rats, Long-Evans; Time Factors; Yohimbine | 2013 |
Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Caffeine; Diazepam; Drug Evaluation, Preclinical; Freezing Reaction, Cataleptic; Serotonin; Swimming; Zebrafish | 2014 |
Survival of ingestion of a potentially lethal dose of caffeine.
Topics: Adult; Antihypertensive Agents; Caffeine; Diazepam; Drug Overdose; Hemodiafiltration; Humans; Hypnotics and Sedatives; Labetalol; Male | 2016 |
Time-dependent interacting effects of caffeine, diazepam, and ethanol on zebrafish behaviour.
Topics: Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; Male; Time Factors; Zebrafish | 2017 |
Impact of stress, fear and anxiety on the nociceptive responses of larval zebrafish.
Topics: Acetic Acid; Analgesics; Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Etomidate; Fear; Larva; Stress, Physiological; Swimming; Zebrafish | 2017 |
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
Topics: Caffeine; Cytochrome P-450 Enzyme System; Diazepam; Female; Granisetron; Humans; Metoprolol; Metronidazole; Midazolam; Models, Biological; Nifedipine; Ondansetron; Pharmaceutical Preparations; Pregnancy | 2018 |
Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa.
Topics: Administration, Buccal; Animals; Caffeine; Diazepam; Epithelium; Levulinic Acids; Lipids; Mannitol; Micelles; Mouth Mucosa; Oleic Acid; Osmolar Concentration; Permeability; Propylene Glycol; Small Molecule Libraries; Sodium Dodecyl Sulfate; Swine | 2018 |
Three- and bi-dimensional analyses of the shoaling behavior in zebrafish: Influence of modulators of anxiety-like responses.
Topics: Algorithms; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Exploratory Behavior; Social Behavior; Zebrafish | 2020 |
The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine.
Topics: Alprazolam; Caffeine; Counterfeit Drugs; Diazepam; Fatal Outcome; Humans; Male; Middle Aged | 2020 |
The larval diving response (LDR): Validation of an automated, high-throughput, ecologically relevant measure of anxiety-related behavior in larval zebrafish (Danio rerio).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Diving; Larva; Reproducibility of Results; Zebrafish | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2022 |