caffeine and dapsone

caffeine has been researched along with dapsone in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.86)	18.7374
1990's	3 (8.57)	18.2507
2000's	12 (34.29)	29.6817
2010's	19 (54.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hein, DW; Weber, WW	1
Guo, R; Lauterberg, B; Thormann, W	1
Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA	1
Adedoyin, A; Branch, RA; Frye, RF; Mauro, K	1
Crane, LR; Doll, MA; Drobitch, RK; Farrough, MJ; Fretland, AJ; Hein, DW; MacArthur, RD; O'Neil, WM; Svensson, CK	1
Adedoyin, A; Branch, RA; Frye, RF; Romkes, M; Wilson, JW	1
Branch, RA; Frye, RF	1
Hu, JP; Xu, YX; Yan, SL; Zhang, JN	1
Arsenault, M; Bélanger, PM; Hamelin, BA; Pilote, S; Sharma, A	1
Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK	1
Ge, B; Jiang, S; Li, Y; Liu, X; Min, G; Tang, H	1
Gao, J; Gao, X; Jia, H; Xu, A; Yuan, J	1
Guo, K; Ji, H; Jiang, SX; Zhang, JR; Zhang, LL; Zhang, Y	1
Jiang, SX; Mo, F; Yu, ZG; Zhang, JR; Zhang, LL; Zhao, J	1
Hang, P; Liu, G; Liu, R; Liu, Y; Qin, M; Zhang, Z	1
Li, X; Liu, G; Liu, Y; Tai, S; Yang, C; Zhang, X	1
Cui, J; Li, J; Li, R; Lin, W; Ling, X; Yang, H; Yu, N; Zhang, J	1
Chang, ZQ; Li, J; Zhai, QQ	1
Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R	1
Amaro, MI; Cabral, LM; da Silva, LCRP; de Almeida, GS; de Sousa, VP; do Amaral, LH; do Carmo, FA; Healy, AM; Rodrigues, CR	1
Dong, M; Liu, D; Liu, G; Qiao, Y; Qin, M; Shi, Y; Xu, J; Zhang, W	1
Cabral, LM; Healy, AM; Todaro, V; Worku, ZA	1

Reviews

2 review(s) available for caffeine and dapsone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
N-acetylation pharmacogenetics. Pharmacological reviews, 1985, Volume: 37, Issue:1 Topics: Acebutolol; Acetyl Coenzyme A; Acetylation; Acetyltransferases; Aminoglutethimide; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Carcinogens; Cricetinae; Dapsone; Disease; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Genotype; Humans; Hydrazines; Kinetics; Liver; Mice; Models, Biological; Mutagens; Pharmaceutical Preparations; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Procainamide; Rabbits; Species Specificity; Substrate Specificity; Sulfasalazine	1985

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

N-acetylation pharmacogenetics.

Pharmacological reviews, 1985, Volume: 37, Issue:1

Topics: Acebutolol; Acetyl Coenzyme A; Acetylation; Acetyltransferases; Aminoglutethimide; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Carcinogens; Cricetinae; Dapsone; Disease; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Genotype; Humans; Hydrazines; Kinetics; Liver; Mice; Models, Biological; Mutagens; Pharmaceutical Preparations; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Procainamide; Rabbits; Species Specificity; Substrate Specificity; Sulfasalazine

1985

Trials

2 trial(s) available for caffeine and dapsone

Article	Year
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4 Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values	1997
Validation of incorporating flurbiprofen into the Pittsburgh cocktail. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged	2006

Article

Year

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.

Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values

1997

Validation of incorporating flurbiprofen into the Pittsburgh cocktail.

Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged

2006

Other Studies

31 other study(ies) available for caffeine and dapsone

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Relationship between high incidence of adverse dapsone reactions and slow acetylate phenotype or low plasma/lymphocyte glutathione level. Chinese medical journal, 1996, Volume: 109, Issue:12 Topics: Acetylation; Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Dapsone; Female; Glutathione; Humans; Lymphocytes; Male; Middle Aged; Phenotype	1996
Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail. British journal of clinical pharmacology, 1998, Volume: 46, Issue:3 Topics: Adult; Analysis of Variance; Antimalarials; Caffeine; Chloroquine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Drug Interactions; Humans; Isoenzymes; Male; Phenotype	1998
Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype. Pharmacogenetics, 2000, Volume: 10, Issue:2 Topics: Acetylation; Adult; Antigens, CD; Arylamine N-Acetyltransferase; Base Sequence; Caffeine; Dapsone; DNA Primers; Female; Genotype; HIV Infections; Humans; Isoenzymes; Male; Middle Aged; Phenotype; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha	2000
In vivo modulation of CYP enzymes by quinidine and rifampin. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4 Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline	2000
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects. British journal of clinical pharmacology, 2002, Volume: 53, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors	2002
[Simultaneous determination of three probe drugs by reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography, 2002, Volume: 20, Issue:6 Topics: Animals; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Dapsone; Male; Rats	2002
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. British journal of clinical pharmacology, 2004, Volume: 58, Issue:3 Topics: Adult; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Drug Combinations; Humans; Male; Metoprolol; Phenformin; Pilot Projects; Tolbutamide	2004
Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs. Journal of ethnopharmacology, 2008, May-22, Volume: 117, Issue:3 Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Bilirubin; Caffeine; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Chromatography, High Pressure Liquid; Dapsone; Drugs, Chinese Herbal; Liver; Liver Function Tests; Male; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar	2008
[Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:16 Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Drugs, Chinese Herbal; Fermentation; Male; Random Allocation; Rats; Rats, Wistar	2009
Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Research in veterinary science, 2011, Volume: 90, Issue:1 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chickens; Ciprofloxacin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Drug Interactions; Enrofloxacin; Fluoroquinolones; Gene Expression Regulation, Enzymologic; Half-Life; Liver; Male; Organ Size; Weight Gain	2011
Effects of ionophores on liver CYP1A and 3A in male broilers. Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:6 Topics: Animals; Blotting, Western; Caffeine; Chickens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Dapsone; Dose-Response Relationship, Drug; Gene Expression; Ionophores; Lactones; Liver; Male; Microsomes, Liver; Monensin; Pyrans; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA, Messenger	2010
Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytotherapy research : PTR, 2012, Volume: 26, Issue:8 Topics: Animals; Blotting, Western; Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Dapsone; Enzyme Activation; Injections, Intraperitoneal; Liver; Male; Metoprolol; Panax notoginseng; Protein Biosynthesis; Rats; Rats, Wistar; Saponins; Tandem Mass Spectrometry; Time Factors; Tolbutamide	2012
UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. Journal of chromatographic science, 2013, Volume: 51, Issue:1 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Drug Stability; Linear Models; Male; Metoprolol; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tolbutamide	2013
Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Apr-01, Volume: 923-924 Topics: Administration, Oral; Animals; Antipyrine; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Limit of Detection; Linear Models; Male; Metoprolol; Omeprazole; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Solid Phase Extraction	2013
Evaluation on activity of cytochrome p450 enzymes in turbot via a probe drug cocktail. Journal of aquatic animal health, 2014, Volume: 26, Issue:4 Topics: Animals; Antitubercular Agents; Area Under Curve; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Enzyme Induction; Flatfishes; Folic Acid Antagonists; Muscle Relaxants, Central; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Rifampin	2014
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes. The Journal of steroid biochemistry and molecular biology, 2016, Volume: 163 Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide	2016
Development and Characterization of Dapsone Cocrystal Prepared by Scalable Production Methods. AAPS PharmSciTech, 2018, Volume: 19, Issue:6 Topics: Administration, Inhalation; Caffeine; Calorimetry, Differential Scanning; Cell Line; Chemistry, Pharmaceutical; Crystallization; Dapsone; Desiccation; Drug Compounding; Dry Powder Inhalers; Humans; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction	2018
Effects of shuanghuanglian injection on the activities of CYP1A2, 2C11, 2D1 and 3A1/2 in rats in vivo and in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:8 Topics: Animals; Caffeine; Calibration; Cytochrome P-450 Enzyme System; Dapsone; Drugs, Chinese Herbal; Injections; Limit of Detection; Male; Metabolome; Metoprolol; Rats, Wistar; Reproducibility of Results; Time Factors; Tolbutamide	2019
In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing. AAPS PharmSciTech, 2019, Jan-02, Volume: 20, Issue:1 Topics: Caffeine; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Dapsone; Drug Combinations; Solvents; X-Ray Diffraction	2019

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