caffeine has been researched along with cyclosporine in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 16 (40.00) | 29.6817 |
| 2010's | 15 (37.50) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF | 1 |
| Cambar, J; L'Azou, B; Lakhdar, B; Potier, M | 1 |
| Aparicio, M; Cambar, J; Potier, M | 1 |
| Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T | 1 |
| Kim, DH; Kim, TK; Park, KS | 1 |
| Bastien, MC; Demers, C; Gascon-Barré, M; Provencher, SJ; Villeneuve, JP | 1 |
| Kim, DH; Kim, TK; Lee, EH; Park, CS; Park, KS | 1 |
| Isenberg, G; Weidelt, T | 1 |
| Bechtel, PR; Bechtel, YC; Brientini, MP; Hrusovsky, S; Lelouët, H; Mantion, G; Miguet, JP; Paintaud, G | 1 |
| Combettes, L; Lompré, AM; Vallot, O | 1 |
| Bandyopadhyay, A; Bhat, MB; Kim, DH; Ma, J; Pan, Z; Shin, DW | 1 |
| Epstein, OI; Ratushnyak, AS; Shtark, MB; Simonova, OG; Zapara, TA | 1 |
| Cheranov, SY; Jaggar, JH | 1 |
| Ducreux, S; Girard, T; Müller, C; Muntoni, F; Quinlivan, R; Restagno, G; Sewry, C; Treves, S; Zorzato, F | 1 |
| Alter, P; Herzum, M; Hohenberger, K; Maisch, M; Ritter, M; Tebbe, J | 1 |
| Hellsten, Y; Jensen, L; Kusuhara, K; Madsen, K; Pilegaard, H | 1 |
| Belmonte, S; Morad, M | 1 |
| Goodisman, J; Jones, E; Souid, AK; Tao, Z | 1 |
| Espinosa, JF; Gil, S; Parella, T | 1 |
| Bakun, AV; Fedosenko, VV; Khlebko, PV; Kustanovich, AM; Serhiyenka, TF; Svirnovski, AI; Taras, IB | 1 |
| Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K | 1 |
| Borutaite, V; Jankeviciute, S; Svirskiene, N; Svirskis, G | 1 |
2 review(s) available for caffeine and cyclosporine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells | 2022 |
38 other study(ies) available for caffeine and cyclosporine
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Grapefruit juice interactions with drugs.
Topics: Beverages; Caffeine; Citrus; Cyclosporine; Estrogens; Felodipine; Food-Drug Interactions; Humans; Midazolam; Nifedipine; Terfenadine | 1995 |
Evidence for a protective effect of theophylline and caffeine on cyclosporine-induced contractions in two in vitro glomerular models.
Topics: Animals; Caffeine; Cyclosporine; Dose-Response Relationship, Drug; Glomerular Mesangium; In Vitro Techniques; Kidney Glomerulus; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors | 1995 |
Protective effect of three xanthine derivatives (theophylline, caffeine and pentoxifylline) against the cyclosporin A-induced glomerular contraction in isolated glomeruli and cultured mesangial cells.
Topics: Animals; Caffeine; Cells, Cultured; Cyclosporine; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Immunosuppressive Agents; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Pentoxifylline; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines | 1997 |
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide | 1998 |
Cyclosporin A treatment alters characteristics of Ca2+-release channel in cardiac sarcoplasmic reticulum.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive Agents; Male; Muscle, Skeletal; Myocardium; Osmolar Concentration; Oxalates; Rats; Rats, Sprague-Dawley; Ruthenium Red; Ryanodine; Sarcoplasmic Reticulum; Sirolimus; Time Factors | 1999 |
Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat.
Topics: Aminopyrine; Animals; Biotransformation; Blotting, Northern; Caffeine; Carbon Radioisotopes; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Activation; Erythromycin; Hepatectomy; Isoenzymes; Liver Regeneration; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substrate Specificity | 1999 |
Cyclosporin A induces alteration of Ca release channel in cardiac sarcoplasmic reticulum.
Topics: Animals; Caffeine; Calcium; Cyclosporine; Heart; Male; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 1998 |
Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle.
Topics: Animals; Caffeine; Calcium; Cyclosporine; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle, Smooth; Potassium Channels; Sarcoplasmic Reticulum; Sirolimus; Tacrolimus; Urinary Bladder | 2000 |
Caffeine metabolism before and after liver transplantation.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Azathioprine; Caffeine; Case-Control Studies; Cyclosporine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Humans; Immunosuppressive Agents; Liver; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Uracil; Xanthine Oxidase | 2001 |
Functional coupling between the caffeine/ryanodine-sensitive Ca2+ store and mitochondria in rat aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Caffeine; Calcium; Calcium-Transporting ATPases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Cell Membrane Permeability; Cells, Cultured; Cyclosporine; Cytosol; Endoplasmic Reticulum; Male; Mitochondria, Muscle; Models, Biological; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Rotenone; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Time Factors | 2001 |
Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.
Topics: Amino Acids; Animals; Blotting, Western; Caffeine; Calcineurin; Calcium; Cation Exchange Resins; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cyclosporine; Dimerization; DNA, Complementary; Down-Regulation; Gene Deletion; Green Fluorescent Proteins; Lipids; Luminescent Proteins; Mice; Muscle, Skeletal; Mutagenesis, Site-Directed; Phosphorylation; Precipitin Tests; Protein Binding; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Sirolimus; Tacrolimus Binding Protein 1A; Transfection | 2002 |
Plasticity of neuronal responses induced by low concentrations of exogenous ligands affecting cellular calcium stores.
Topics: Animals; Caffeine; Calcium; Central Nervous System Stimulants; Cyclosporine; Drug Interactions; Humans; Lymnaea; Neuronal Plasticity; Neurons | 2004 |
Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries.
Topics: Animals; Bongkrekic Acid; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Calcium-Binding Proteins; Calcium-Transporting ATPases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Arteries; Clonazepam; Cyclosporine; Diltiazem; Female; Hydrogen Peroxide; Indazoles; Ion Channels; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria, Muscle; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Smooth Muscle; Oligomycins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rhodamines; Rotenone; Ruthenium Compounds; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Thapsigargin; Thiazepines | 2004 |
Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease.
Topics: Caffeine; Calcium; Cells, Cultured; Cycloheximide; Cyclosporine; Disease Susceptibility; Homeostasis; Humans; Interleukin-6; Kinetics; Malignant Hyperthermia; Muscle Fibers, Skeletal; Myopathy, Central Core; Reference Values; Ryanodine Receptor Calcium Release Channel | 2004 |
Caffeine inhibits cytokine expression in lymphocytes.
Topics: Animals; Caffeine; Calcium; Central Nervous System Stimulants; Concanavalin A; Cyclosporine; Cytokines; Enzyme Inhibitors; Gene Expression; Lymphocytes; Mice; Mice, Inbred BALB C; Ryanodine; Spleen | 2005 |
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium Signaling; Cells, Cultured; Cyclosporine; Electric Stimulation; Gene Expression Regulation; Hexokinase; Ionomycin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Rats; Rats, Wistar; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2007 |
Shear fluid-induced Ca2+ release and the role of mitochondria in rat cardiac myocytes.
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cyclosporine; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Rats; Rotenone; Sarcoplasmic Reticulum; Ventricular Function | 2008 |
Quantitative measure of cytotoxicity of anticancer drugs and other agents.
Topics: Antineoplastic Agents; Caffeine; Cell Death; Cell Respiration; Cyclosporine; Dactinomycin; Doxorubicin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Jurkat Cells; Platinum Compounds; Tirapazamine; Triazines | 2008 |
IPAP-HSQMBC: measurement of long-range heteronuclear coupling constants from spin-state selective multiplets.
Topics: Algorithms; Caffeine; Carbon; Cyclosporine; Electromagnetic Fields; Electron Spin Resonance Spectroscopy; Magnetic Resonance Spectroscopy; Nitrogen; Protons; Strychnine | 2010 |
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; ATP Binding Cassette Transporter, Subfamily B; Benzaldehydes; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclosporine; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins; Vidarabine | 2010 |
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Computer Simulation; Cyclosporine; Female; Gastrointestinal Tract; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Obesity, Morbid; Pharmacokinetics; Phenytoin; Regional Blood Flow; Theophylline; Young Adult | 2011 |
Effects of Metformin on Spontaneous Ca
Topics: Animals; Caffeine; Calcium Signaling; Chromans; Cyclosporine; Electron Transport Complex I; Female; Hypoxia; Male; Metformin; Microglia; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Primary Cell Culture; Rats; Reactive Oxygen Species; Rotenone | 2021 |