caffeine has been researched along with coumarin in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Akamatsu, M | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V | 1 |
| Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD | 1 |
| Bracken, W; Bullock, P; Draper, A; Parkinson, A; Pearce, R; Podval, J; Thomas, P; Veltman, J | 1 |
| Harris, JE | 1 |
| Arvela, P; Mustajoki, P; Mustajoki, S; Pelkonen, O; Rautio, A | 1 |
| Darroudi, F; Knasmüller, S; Nagao, M; Parzefall, W; Sanyal, R | 1 |
| Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T | 1 |
| Ikemoto, N; Rodriguez, J; Yamamoto, T | 1 |
| Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M | 1 |
| Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US | 1 |
| Arakawa, T; Hirano, A; Shiraki, K | 1 |
| Crispim, SP; De Vries, JH; Geelen, A; Le Donne, C; Leclercq, C; Ocke, MC; Raffo, A; Sette, S; Siebelink, E; van't Veer, P | 1 |
| Berka, K; Otyepka, M; Paloncýová, M | 1 |
| Briesen, H; Gajewska, M; Schramm, KW; Urani, C; Worth, A | 1 |
| Erastov, AA; Kostanyan, AE; Shishilov, ON | 1 |
| Capelo, JL; Cavaleiro, JA; Faustino, MA; Lodeiro, C; Menezes, JC; Neves, Mda G; Oliveira, E; Santos, CI; Santos, HM | 1 |
| Erastov, AA; Kostanyan, AE | 2 |
| Kostanyan, A; Martynova, M | 1 |
| Baltazar, MT; Lee, MY; Li, H; Moxon, TE; Nicol, B; Pendlington, R; Pickles, J; Piechota, P; Sorrell, I | 1 |
1 review(s) available for caffeine and coumarin
| Article | Year |
|---|---|
Interaction of dietary factors with oral anticoagulants: review and applications.
Topics: Administration, Oral; Alcoholic Beverages; Allium; Anticoagulants; Beverages; Caffeine; Coumarins; Dietary Fats; Food-Drug Interactions; Humans; Peptide Hydrolases; Silicones; Vitamin K; Vitamins | 1995 |
1 trial(s) available for caffeine and coumarin
| Article | Year |
|---|---|
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged | 2007 |
29 other study(ies) available for caffeine and coumarin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice | 2020 |
Induction of liver microsomal cytochrome P450 in cynomolgus monkeys.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Caffeine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochromes b5; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxazines; Oxidation-Reduction; Phenobarbital; Sex Factors; Species Specificity; Testosterone | 1995 |
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Topics: Adult; Arginine; Caffeine; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Heme; Humans; Isoenzymes; Lidocaine; Male; Middle Aged; Porphyrias, Hepatic; Reference Values | 1994 |
Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens.
Topics: Acrolein; Amines; Antimutagenic Agents; Benzaldehydes; Caffeine; Carbolines; Carcinoma, Hepatocellular; Coumarins; DNA Repair; Heterocyclic Compounds; Humans; Hydrolyzable Tannins; Imidazoles; Micronucleus Tests; Mutagens; Quinolines; Tumor Cells, Cultured | 1997 |
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide | 1998 |
Ca2+-dependent dual functions of peptide C. The peptide corresponding to the Glu724-Pro760 region (the so-called determinant of excitation-contraction coupling) of the dihydropyridine receptor alpha 1 subunit II-III loop.
Topics: Animals; Caffeine; Calcium; Calcium Channels, L-Type; Calpain; Coumarins; Fluorescent Dyes; Microsomes; Muscle, Skeletal; Myocardium; Peptide Fragments; Polylysine; Protein Binding; Protein Structure, Secondary; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel | 2002 |
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene | 2005 |
Arginine increases the solubility of coumarin: comparison with salting-in and salting-out additives.
Topics: Arginine; Benzyl Alcohols; Biochemistry; Caffeine; Coumarins; Dose-Response Relationship, Drug; Guanidine; Hydrogen-Ion Concentration; Models, Biological; Salts; Solubility; Surface Properties; Urea; Water | 2008 |
Dietary exposure to flavouring substances: from screening methods to detailed assessments using food consumption data collected with EPIC-Soft software.
Topics: Aged; Butanones; Caffeine; Coumarins; Diet; Diet Records; Female; Flavoring Agents; Food; Glycyrrhizic Acid; Humans; Male; Middle Aged; Netherlands; Software; Surveys and Questionnaires | 2010 |
Molecular insight into affinities of drugs and their metabolites to lipid bilayers.
Topics: Caffeine; Cell Membrane; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Ibuprofen; Lipid Bilayers; Molecular Dynamics Simulation; Pharmaceutical Preparations; Phosphatidylcholines; Phosphatidylglycerols; Thermodynamics; Xenobiotics | 2013 |
Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients.
Topics: Administration, Cutaneous; Administration, Oral; Algorithms; Animals; Antioxidants; Caffeine; Calibration; Central Nervous System Stimulants; Cosmetics; Coumarins; Data Interpretation, Statistical; Humans; Hydroquinones; Liver; Models, Statistical; No-Observed-Adverse-Effect Level; Pharmacokinetics; Quantitative Structure-Activity Relationship; Rats; Skin; Skin Absorption; Species Specificity | 2014 |
Multiple dual mode counter-current chromatography with variable duration of alternating phase elution steps.
Topics: Aspirin; Caffeine; Coumarins; Countercurrent Distribution; Models, Theoretical; Salicylic Acid | 2014 |
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study.
Topics: Caffeine; Cotinine; Coumarins; Ethanol; Fresh Water; Molecular Structure; Nicotine; Photochemical Processes; Porphyrins; Portugal; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Ultraviolet Rays; Zinc | 2015 |
Theoretical study of closed-loop recycling liquid-liquid chromatography and experimental verification of the theory.
Topics: Acetates; Aspirin; Caffeine; Coumarins; Countercurrent Distribution; Ethanol; Hexanes; Models, Theoretical; Recycling; Reproducibility of Results; Solutions; Solvents; Water | 2016 |
Industrial countercurrent chromatography separations based on a cascade of centrifugal mixer-settler extractors.
Topics: Caffeine; Centrifugation; Coumarins; Countercurrent Distribution; Metals, Rare Earth; Models, Theoretical; Solvents | 2018 |
Modeling of two semi-continuous methods in liquid-liquid chromatography: Comparing conventional and closed-loop recycling modes.
Topics: Caffeine; Chemistry Techniques, Analytical; Coumarins; Hexanes; Models, Chemical; Solvents; Water | 2020 |
Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products.
Topics: Administration, Cutaneous; Caffeine; Computer Simulation; Consumer Product Safety; Cosmetics; Coumarins; Detergents; Humans; Isothiocyanates; Models, Biological; Risk Assessment; Skin Absorption; Sulfoxides | 2020 |